ライフサイエンスコーパス: electrophilicity

1 the driving force to obtain increased alkyl electrophilicity.

2 e poles of three helices, for increasing its electrophilicity.

3 ear dependency of cross-linking rates on the electrophilicity.

4 not overbearing steric congestion and lower electrophilicity.

5 electron deficient' carries a connotation of electrophilicity.

6 ndrance or attenuation of the acyl-sulfamide electrophilicity.

7 ingly dissolved polysulfides via electrolyte electrophilicity.

8 o the quaternary nitrogen possessing greater electrophilicity.

9 eaction by taking advantage of its intrinsic electrophilicity.

10 y may be primarily attributed to an enhanced electrophilicity.

11 suggested the possibility of boron-centered electrophilicity.

12 ble binding affinity (K(i)) or the intrinsic electrophilicity.

13 unusual methylation substrates due to their electrophilicity.

14 , one with greater and the other with lesser electrophilicity.

15 ules by virtue of their dual nucleophilicity/electrophilicity.

16 anine, effects did not correlate at all with electrophilicities.

17 d phenyl propargyl alcohols having different electrophilicities.

18 To enhance the carbonyl electrophilicity, an alpha-difluorinated analogue (R = H

19 rmed with a range of substrates with various electrophilicities and nucleofugalities consistently sug

20 By tuning the electrophilicity and appended recognition elements, we d

21 features of silyl cations are their enormous electrophilicity and as such reactivity as super Lewis a

22 lpropenoyl)oxazolidin-2-ones, featuring high electrophilicity and conformational homogeneity, are syn

23 (e.g., narcosis), reactive mechanisms (e.g., electrophilicity and free radical action), and specific

24 shift values; it also leads to an increased electrophilicity and higher reactivity for catalysts up

25 esent MEDT study proves that analysis of the electrophilicity and nucleophilicity indices is an excel

26 f several fluorinated radicals through their electrophilicity and nucleophilicity parameters.

27 ighlights the remarkable correlation between electrophilicity and oxidizing ability.

28 ocused on crafting reactive groups of proper electrophilicity and positioning toward targeted amino-a

29 etics exhibits a significant reliance on the electrophilicity and quantity of benzene rings, the conc

30 B) provides an effective means of predicting electrophilicity and reactivity trends across a broad ra

31 ic and electronic factors that influence the electrophilicity and reversibility of Michael acceptors.

32 eagents for bioconjugation due to their high electrophilicity and selectivity for reaction with thiol

33 Electrophilicity and unique steric environment of "sandw

34 plet to singlet intersystem crossing and the electrophilicity) and on the medium (formation of a comp

35 arity/polarizability, hydrogen-bond acidity (electrophilicity), and hydrogen-bond basicity (nucleophi

36 rd halogen bond formation by enhancing their electrophilicity, and explain the absence of M-Cl...F-C

37 nslates to coordination distortion, may tune electrophilicity, and hence, reactivity.

38 ordinate carbon centre maintains significant electrophilicity, and possesses two accessible vacant or

39 the magnitude of this switch on Te-centered electrophilicity, and therefore anion-binding affinity,

40 use these early transition cations have high electrophilicity, and therefore good binding strength wi

41 nitrogen valence, which directly impacts the electrophilicity, and thus biological activity, of the r

42 The increased electrophilicity at O promotes C-O dissociation in the 8

43 ion in reactivity reflects the difference in electrophilicity between the various rhodium carbenoid i

44 vely monoallylated, even overcoming inherent electrophilicity bias.

45 Manipulation of PhOBtz electrophilicity by attaching chlorine substituents to t

46 nones feature an exclusive ability to switch electrophilicity by interconversion between para- and an

47 CF(2)) species with both nucleophilicity and electrophilicity by switching the valence state of the p

48 Increasing the boron electrophilicity by the transformation of a boronate moi

49 Electrophilicity can be conferred by both enzymatic and

50 ndency to exhibit greater nucleophilicity vs electrophilicity can be established using the DeltaG(B)

51 e, as 1,3,2-dioxaborinanes exhibit decreased electrophilicity compared to esters derived from 1,2- or

52 zhydrylium ions are on the same log k2 vs E (electrophilicity) correlation shows that both reaction s

53 A local multiorbital electrophilicity descriptor, the local electron attachme

54 humol also increased respiration, suggesting electrophilicity did not play a role.

55 otocyclization, consistent with the enhanced electrophilicity displayed by the ring-closed form.

56 While electrophilicities E correlate poorly with the LUMO ener

57 2) were found to correlate linearly with the electrophilicities E of the reference electrophiles, as

58 efficiencies were found to increase with the electrophilicity (EA) of the radical.

59 Due to their inherent ring strain and electrophilicity, epoxides are highly attractive buildin

60 tive stability of solvents, dominated by the electrophilicity (EPT) and coordination ability (CDA), d

61 s of steric congestion and dirhodium-carbene electrophilicity in controlling the site of C-H function

62 ematically understanding nucleophilicity and electrophilicity in the absence of a solvent.

63 gh reactivity can be traced to the increased electrophilicity in the oxidized complex.

64 n = 3 (1.16), supporting the hypothesis that electrophilicity increases concomitantly with substituti

65 The computed natural charges reveal that electrophilicity increases upon both annelation and carb

66 e as the carbene stability decreases and its electrophilicity increases, and also as alkene reactivit

67 logarithmic correlation with the calculated electrophilicity index (omega).

68 strength, and with the changes in the Global Electrophilicity Index determined with high accuracy for

69 d a moderate HOMO-LUMO gap (1.827 eV) and an electrophilicity index of 3.492 eV, consistent with favo

70 oorly with the LUMO energies and with Parr's electrophilicity index omega, good correlations were fou

71 died by evaluating their nucleophilicity and electrophilicity indices.

72 en discussed in terms of nucleophilicity and electrophilicity indices.

73 ichael reaction of alcohols to tethered, low electrophilicity Michael acceptors is described.

74 Verifying the pronounced electrophilicity, nucleophiles such as H(2)O and (t)BuNH

75 this influence and predict its effects, the electrophilicity/nucleophilicity of >500 radicals has be

76 ophiles and the measured rate constants, the electrophilicities of the indol-3-ylmethylium ions 3(a-k

77 re enzyme catalysis, but rather exploits the electrophilicity of 1,3-BPG, was found by proteomic prof

78 nditions, consistent with an increase in the electrophilicity of a high-valent iron-oxo intermediate

79 Not all PLP enzymes require the electrophilicity of a protonated pyridine ring to enable

80 We found that the electrophilicity of AdoMet and its onium congeners follo

81 In this work, we exploited the electrophilicity of Ag(II) centers in [Ag(bpy)(2)(TFA)][

82 Both approaches capitalize on the electrophilicity of alpha-sulfonyl radicals and their pr

83 sess the primary coordination sphere and the electrophilicity of alphaKG.

84 of CO(2) is misguiding, considering the high electrophilicity of C(sp) of CO(2), the seemingly omnipr

85 , that forms a C-C bond, is sensitive to the electrophilicity of carbonyl, which can be tuned by a ge

86 ation of Ni (OH)2 to NiOOH by increasing the electrophilicity of catalytic interface.

87 ucleophilicity of the starting arene and the electrophilicity of cationic intermediates generated fro

88 am-scale synthesis, and because of the lower electrophilicity of CH(3)SCH(2)(+), they also work in pa

89 By exploiting the inherent electrophilicity of diaryliodonium salts, we have found

90 The electrophilicity of DMF suggests that its immunosuppress

91 ergy trends and resulting nucleophilicity or electrophilicity of fluorinated radicals.

92 The high electrophilicity of hypervalent iron oxo species is devi

93 r E, provide insights into the full range of electrophilicity of organic functional groups.

94 The observed reactivity is opposite to the electrophilicity of polar carbonyl groups resulting from

95 s that MtbB and MttB may exploit the unusual electrophilicity of pyrrolysine during catalysis.

96 trol of regioselectivity is not trivial, the electrophilicity of remote sites is extenuated, and the

97 er surface can affect the reactive sites and electrophilicity of SO2.

98 nd sulfonimidamides, which exploits the high electrophilicity of sulfinyl nitrenes.

99 reduction are positively correlated with the electrophilicity of the active site pyrazine unit and ca

100 cs over distinct time domains by varying the electrophilicity of the acylating reagent.

101 iazeniumdiolate group greatly suppresses the electrophilicity of the adjacent C horizontal lineN carb

102 The trifluoromethyl group increased the electrophilicity of the adjacent carbonyl group and decr

103 However, the intrinsic, high electrophilicity of the aldehyde group is associated wit

104 ormation ( k(inact)) does not correlate with electrophilicity of the alkyne moiety, indicative of a p

105 based on just one specific dipole class, the electrophilicity of the alkynes in SNO-OCTs can be manip

106 d AM product cannot be explained by a higher electrophilicity of the alpha-carbon compared to the bet

107 oselectivity observed is a result of greater electrophilicity of the alpha-keto ester toward the Bres

108 Herein, we describe chemically tuning the electrophilicity of the alpha-methylene-gamma-lactone by

109 (2) The hydrogen bonding reduces the electrophilicity of the ammonium protons by donating ele

110 through ring strain, salicylates reduce the electrophilicity of the aryl ester through an intramolec

111 ctroscopy provides no evidence for increased electrophilicity of the beta-vinyl carbons (the presumed

112 ddition upon binding to an enzyme due to the electrophilicity of the boron atom.

113 transmetalation is enhanced with increasing electrophilicity of the boron center.

114 owing to their intrinsic instability, strong electrophilicity of the boron centre and pronounced non-

115 f the imidazole component that increases the electrophilicity of the C-2 position on the imidazole.

116 ture/activity relationships suggest that the electrophilicity of the C2-C3 olefin is critical for the

117 is structural modification leads to enhanced electrophilicity of the carbene center with retention of

118 The electrophilicity of the carbonyl group in the resulting

119 ingle activation mode, such as enhancing the electrophilicity of the carboxylic acid partner using a

120 red to as the "axial gateway", maintains the electrophilicity of the catalyst by shielding the reacti

121 toward ambient nucleophiles due to the high electrophilicity of the cationic fluorophore core.

122 ridinyl nitrogen of the PLP, influencing the electrophilicity of the cofactor.

123 , O-transfer-reactivity follows the relative electrophilicity of the complexes, whereas the correspon

124 n contrast to penicillin, which enhances the electrophilicity of the cyclic amide through ring strain

125 We show that the electrophilicity of the diazofluorene appears to be a si

126 ) group, which can be combined with the high electrophilicity of the difluoroketone motif.

127 ethylaniline groups were added to reduce the electrophilicity of the dyes toward nucleophiles such as

128 t in choline oxidase, His(466) modulates the electrophilicity of the enzyme-bound flavin and the pola

129 flavinylation of the protein, the decreased electrophilicity of the flavin, and the consequent loss

130 Due to the electrophilicity of the fluorinated amide, this palladiu

131 uction in activity is due to the decrease in electrophilicity of the FMN.

132 tron-donating group that attenuates the high electrophilicity of the gold carbene center.

133 le substrate, underscoring the cruciality of electrophilicity of the heme superoxide moiety in facili

134 hetic study with different nucleophiles, the electrophilicity of the intermediate iminium ion was est

135 finding was explained in terms of the higher electrophilicity of the iron center and the higher avail

136 Electrophilicity of the ligand-binding Mg ion is increas

137 This effect increases electrophilicity of the metal and lowers the calculated

138 he field remains challenging due to the high electrophilicity of the metal carbene intermediates.

139 This protonation enhances the electrophilicity of the methyl group, in agreement with

140 ociation being retained, reflecting the high electrophilicity of the Mg center.

141 These data suggest that the two-electron electrophilicity of the Mn(O) valence tautomers dominate

142 recting group allowed for fine-tuning of the electrophilicity of the mononuclear [LCuOOH](1+) to reac

143 g correlation was found to exist between the electrophilicity of the N-Boc carbonyl group and the rea

144 show that this is primarily due to a greater electrophilicity of the palladium containing fragment, a

145 adical to damage dipeptides increases as the electrophilicity of the phenyl radical increases.

146 However, the high electrophilicity of the phosphorus center has so far pre

147 entatives has been attributed to the extreme electrophilicity of the putative C-NacNac adducts.

148 f the radicals studied was determined by the electrophilicity of the radical, which can be characteri

149 A systematic increase in the electrophilicity of the radicals by modification of the

150 The electrophilicity of the radicals does not appear to have

151 d on the ratio of the E/Z isomers but on the electrophilicity of the reactive [LCuOOH](1+).

152 This difference is rationalized based on the electrophilicity of the respective M-C(sp(3) ) bonds, an

153 strongly dependent on both the polarity and electrophilicity of the solvent and (ii) solvatochromic

154 They increase the electrophilicity of the tritopic aldehyde and the rate o

155 m functional group tolerance due to the high electrophilicity of the V center, making it impractical

156 oordination number and polarity may tune the electrophilicity of zinc.

157 w a strong relationship between the computed electrophilicity, omega, of a radical and its relative r

158 The critical role of the carbene electrophilicity on the outcome of reactions is discusse

159 The higher the electrophilicity (or EA) of the radical, the greater the

160 allowed for the quantification of benzyne's electrophilicity parameter.

161 rameters (N, DeltaG(AuCl), and TEP), and the electrophilicity parameters (hydride ion affinity, fluor

162 Eventually it is demonstrated that the electrophilicity parameters determined in this work can

163 cted to a correlation analysis to derive the electrophilicity parameters E for acceptor-substituted b

164 N) allowed us to calculate 15 new empirical electrophilicity parameters E for Michael acceptors 1 an

165 the diffusion-clock method and also provides electrophilicity parameters E for other substituted aryn

166 nzhydrylium ions correlate linearly with the electrophilicity parameters E of the benzhydrylium ions

167 in CH3CN solution and used to determine the electrophilicity parameters E of the cations defined by

168 termined in this work were combined with the electrophilicity parameters E of the corresponding catio

169 It was, therefore, possible to calculate the electrophilicity parameters E of the different positions

170 fferent quinones correlate linearly with the electrophilicity parameters E of the quinones, which hav

171 d from the linear plots of log k2 versus the electrophilicity parameters E of these reference electro

172 The electrophilicity parameters E thus determined can be use

173 imated here using Mayr's nucleophilicity and electrophilicity parameters fine-tuned by correction ter

174 With electrophilicity parameters from E = -10.69 (Ar = p-MeOC

175 Despite that electrophilicity parameters have now been established fo

176 20 degrees C) = s(N)(N + E) to determine the electrophilicity parameters of the heteroallenes: TsNCO

177 he heteroatom, enabled by intrinsic relative electrophilicity, particularly in strongly polarized sys

178 Their electrophilicity permits anion detection through additio

179 It is proposed that modulation of cofactor electrophilicity plays a central role in controlling rea

180 Group nucleophilicity and electrophilicity profiles help describe the bond-breakin

181 A new empirical electrophilicity reactivity parameter, E(RB), was develo

182 Strain-enhanced electrophilicity renders aziridines useful synthetic int

183 The radicals' different electrophilicities result in variations in the reaction

184 ctive pocket and one measuring the metal ion electrophilicity reveals the degradation ability improve

185 available group 13 Lewis acids that range in electrophilicity, steric bulk, and Pearson hard/soft-nes

186 attributed to it possessing higher inherent electrophilicity than [Cu(II)(eta(1)-O(2)(*-))(2)](+), w

187 n to its elemental form because of its lower electrophilicity than carbonate molecule or anion, whose

188 hat require geometric constraints to enhance electrophilicity, the new mode of bond activation in thi

189 alyst generates an iminium ion of sufficient electrophilicity to enable 1,2-attack by an alcohol.

190 olethiyl radical imparting increased radical electrophilicity to facilitate the hydrogen atom transfe

191 s with electrophilic character that transfer electrophilicity to silicon by Si-H activation.

192 On the Mayr E scale, the electrophilicity toward the methyl anion spans 180 order

193 ting reactivity of isopropylidene oxindoles (electrophilicity vs nucleophilicity) in the presence of

194 hemical softness (o), electronegativity (x), electrophilicity (w) and nucleophilicity (e).

195 QMs' spectroscopic properties and electrophilicity were both significantly affected by bet

196 Six reactive groups with modulated electrophilicity were combined with 11 nonreactive moiet

197 idifying effect on peptide backbones and its electrophilicity which allows site-specific thiol ligati

198 The iminium intermediate displays enhanced electrophilicity, which facilitates conjugate additions

199 We postulated that this mild electrophilicity would demand a longer residence time ne