ライフサイエンスコーパス: elimination

1 so to inform control policies to aid disease elimination.

2 bonds in unstrained alcohols via beta-carbon elimination.

3 y specific therapy for intestinal pathobiont elimination.

4 not alter the efficacy of BCG-induced tumor elimination.

5 lso be abnormal without C1q-mediated synapse elimination.

6 important roles in pathogen recognition and elimination.

7 rum are major threats to malaria control and elimination.

8 tage parasites will be essential for malaria elimination.

9 herapy and target virus-expressing cells for elimination.

10 y)(3) supports a turnover-limiting reductive elimination.

11 s, slow U uptake rates from food, and fast U elimination.

12 ugh sequential olefin insertion/beta-hydride elimination.

13 onal circuits predominantly involves synapse elimination.

14 a solium taeniasis/cysticercosis control and elimination.

15 rt resulting inflammatory responses to avoid elimination.

16 nsertion into the M-P bond and C-H reductive elimination.

17 ons which facilitate decomposition via alpha-elimination.

18 nd follow-up as the country prepares for HCV elimination.

19 have served to increase interest in typhoid elimination.

20 y nucleophilic fluorination due to competing elimination.

21 al addition-SET-oxidative addition-reductive elimination.

22 s to mosquitoes, are key targets for malaria elimination.

23 den, a necessary step in the pathway towards elimination.

24 generated in situ, and subsequent reductive elimination.

25 that regulates complement-dependent synapse elimination.

26 hat are appealing for noninvasive arrhythmia elimination.

27 ione-dependent alkyltransferase or reductive elimination activities.

28 ights the advances in the use of MOFs in the elimination (adsorption and/or degradation) of EOCs from

29 Here, we introduce a novel 'cannibalistic' elimination algorithm ("Hungry, Hungry SNPos") that atte

30 on-reproducible radiomics features, backward elimination analyses identified a single model which was

31 In patients, both stepwise backward elimination and Bayesian model selection revealed an opt

32 ely replace trypanolysis for monitoring gHAT elimination and for post-elimination surveillance.

33 ion of the diene is followed by beta-hydride elimination and hydride reinsertion to give a 6-membered

34 of REM sleep in experience-dependent synapse elimination and neuronal activity reduction.

35 (P < .01) covariates remained after backward elimination and no effect of asparaginase or azoles were

36 inform surveillance strategies for detecting elimination and resurgence.

37 e an ultrastructural analysis of Ascaris DNA elimination and show that eliminated DNA is incorporated

38 tudies revealed that unusually double beta-F eliminations and fluorine effect-induced regioselective

39 (a) ligand-metal charge transfer, (b) CF(3) elimination, and (c) C-C bond rotation processes.

40 and dupilumab for OCS dosage reduction, OCS elimination, and annual exacerbation rate reduction.

41 u, Ad) afforded by C-H activation, isobutene elimination, and C-C and P-H bond formation bicyclic 1-b

42 ssed the probability of elimination, time to elimination, and percentage of cases averted with OCV ca

43 The absorption, distribution, metabolism, elimination, and toxicity (ADMET) properties of drug can

44 Oxidative addition and reductive elimination are defining reactions of transition-metal o

45 rine effect-induced regioselective reductive elimination are independently involved to enable distinc

46 es by oxidative addition and their reductive elimination, are much better understood.

47 The World Health Organization (WHO) has set elimination as a public health problem (EPHP) as a goal

48 e addition, ligand metathesis, and reductive elimination at a C(s)-symmetric phosphorus triamide (1,

49 er for C-CN oxidative addition and reductive elimination at benzylic positions in the absence of a co

50 oducing twice-lifetime screening accelerated elimination by 11-31 years.

51 Here, we asked whether HCV-elimination by sofosbuvir-based direct-acting antivirals

52 al of exposing hidden reservoirs of HIV-1 to elimination by the immune system.

53 Persistent pathogens have evolved to avoid elimination by the mammalian immune system including mec

54 It is only by selection, by elimination, by emphasis, that we get at the real meanin

55 In 2016, the Zambian National Malaria Elimination Centre started programmatic mass drug admini

56 as parasite prevalence are under powered in elimination contexts.

57 on to previously discovered mechanisms, cell elimination contributes to regulating lateral root emerg

58 Myanmar is a premalaria elimination country with artemisinin-resistant malaria.

59 duce T cell-mediated immunity, whether tumor elimination depends on bacteria-specific or tumor-specif

60 implicated catalyst initiation via a beta-H elimination/deprotonation pathway.

61 ve indicated that less-restrictive, empiric, elimination diets can be effective and reduce the need f

62 Therapies include proton pump inhibitors, elimination diets, and topical corticosteroids.

63 not been seen as a primary tool for cholera elimination due to a limited period of protection and co

64 philic substitution (S(N)2) and base-induced elimination (E2) pathways for F(-) + CH(3)CH(2)Cl and PH

65 quisite biological and technical factors for elimination, effective interventions exist for typhoid,

66 uld be viewed as a critical challenge to any elimination effort.

67 For malaria elimination efforts it is important to better understand

68 In the context of global malaria elimination efforts, special attention is being paid to

69 s C virus (HCV) screening is critical to HCV elimination efforts.

70 ined time period could contribute to malaria elimination efforts.

71 ode Ascaris demonstrated that programmed DNA elimination encompasses high-fidelity chromosomal breaks

72 ights are used to highlight drivers of local elimination, evaluate strategies for detecting resurgenc

73 Deltargg2 bacteria suggests that their rapid elimination failed to elicit the previously characterize

74 or aqueous U uptake, dietary U uptake, and U elimination for the aquatic baetid mayfly Neocloeon tria

75 ecedented and fast aryl C(sp(2))-X reductive elimination from a series of isolated Pt(IV) aryl comple

76 Whereas rapid beta-hydrogen elimination from cobalt alkyls occurred under an N(2) at

77 f H(2) from dihydride 3 or via reductive C-H elimination from monohydride 2.

78 as further supported by monitoring hydrogen elimination from radical a-ions produced by UVPD at the

79 s show lowers the barrier for reductive H(2) elimination from the bimetallic cleft.

80 e physiological clearance of gold, with >85% elimination from the liver over three months.

81 Ni-bound amine and the barrier to reductive elimination from the resultant Ni(II)-amido complex.

82 e programme and feasibility of achieving the elimination goal.

83 rted countries are on track to achieve their elimination goals (for lymphatic filariasis and trachoma

84 oup and 1 recurrence in the CS-LA connection elimination group (46.7% versus 6.7%, hazard ratio, 0.12

85 Though the blood elimination half-life of contrast agents is about 90 min

86 ion of the mechanisms that regulate pathogen elimination, immunity, and pathology is essential to bet

87 ia, resulting in complement-mediated synapse elimination in AD models.

88 iasis is needed to accelerate onchocerciasis elimination in Africa.

89 rotects synapses against complement-mediated elimination in both the thalamus and the cortex.

90 knockout plants by genetically inducing cell elimination in cells overlying the LRP or by physically

91 Cancer elimination in humans can be achieved with immunotherapy

92 ns can be an invaluable tool towards malaria elimination in low endemicity areas, specifically when p

93 se two factors are barriers to achieving HIV elimination in Malawi and assessed the effect of increas

94 ay be required to eventually achieve malaria elimination in stable transmission areas of sub-Saharan

95 own to be required for developmental synapse elimination in the mouse visual thalamus as well as sens

96 tivation and complement C3-dependent synapse elimination in vivo.

97 of tuberculosis (TB) is essential to achieve elimination, including in low-incidence settings.

98 st the mechanism of the subsequent reductive elimination is a unimolecular process occurring on the l

99 Elimination is also shown to occur through an acid-catal

100 However, whether malaria elimination is feasible in areas of stable transmission

101 If elimination is impracticable due to resource limitations

102 Our results indicate that malaria elimination is only realistically achievable in settings

103 design and management of long-term parasite elimination, it is becoming clear that transmission mode

104 es were observed for the measured uptake and elimination kinetics, with bioconcentration factors (BCF

105 ted by assuming one compartment, first-order elimination kinetics.

106 However, programmed DNA elimination leads to a reduced somatic genome compared t

107 l gold particles within a larger entity, but elimination may still be protracted due to incomplete di

108 nd deprotonation could not undergo reductive elimination meaning a "dead-end route".

109 to disentangle the unimolecular 3-center DCN elimination mechanism from other pathways to HCN.

110 er, chemical releasing methods, such as beta-elimination/Michael addition, are not specific to O-glyc

111 ation will help to set up achievable malaria elimination milestones and guide the creation of efficie

112 ar to micronuclei, during telophase of a DNA elimination mitosis.

113 The WHO Cervical Cancer Elimination Modelling Consortium (CCEMC) involves three

114 The WHO Cervical Cancer Elimination Modelling Consortium (CCEMC), which consists

115 as also evident in R6/2 mice, and microglial elimination not only prevented this but also strikingly

116 ted to support that this dinuclear reductive elimination occurs by tautomerization of the metal hydri

117 in situ trapping of [BO(2) ](-) produced by elimination of 2,3-dimethyl-2-butene from a pinacolatobo

118 f incorrect assumptions about absorption and elimination of a drug and its effect on tumor growth.

119 The elimination of a drug or marker selection step avoids th

120 Curing HIV infection will require the elimination of a reservoir of infected CD4+ T cells that

121 bous spines on relay neurons, leading to the elimination of a subset of connections.

122 ic activities of the TBPCExBox(4+) , for the elimination of a sulfur mustard simulant, has proved to

123 ation occurs concurrently with the apoptotic elimination of a third of GABAergic interneurons.

124 Selective autophagic elimination of aggregates is critical to protein quality

125 ns is a pathogenic driver, and the selective elimination of aggregates may confer disease resistance.

126 In one scenario, we estimate that elimination of all unnecessary outpatient antibiotic use

127 reserved in mature hippocampus despite early elimination of AMPARs, which resulted in >90% decrease i

128 hat the reversal of acute AMR requires rapid elimination of antibody-secreting plasma cells (PC) with

129 1.[H][Ar(F)] regenerates 1 by C-H reductive elimination of Ar(F)-H, where experimental and computati

130 he Firmicutes and Proteobacteria phyla, near elimination of Bacteroidetes, and marked reductions in c

131 locations in soft grains and, sometimes, the elimination of basal dislocations in hard grains altoget

132 bition of virus release, and immune-mediated elimination of both free virus and virus-infected cells.

133 LD showed substantially better targeting and elimination of brain tumors after intravenous delivery a

134 Elimination of branched N-glycans in developing B cells

135 Specific elimination of CG methylation did not dysregulate transp

136 creased frequency excursion, lower power and elimination of channel distortions resulting from the so

137 and that bolder action is needed to promote elimination of cholera from the region.

138 y examining perceptual effects of widespread elimination of cortical direction selectivity produced b

139 nificantly activated in the absence of Hh by elimination of Cos2, likely acting through binding the C

140 termination is completely abolished by rapid elimination of CPSF73, which causes very extensive trans

141 Genetic elimination of D2Rs on striatopallidal neurons (iMSNs),

142 Temporally harmonized elimination of damaged or unnecessary organelles and cel

143 s required for their proper function and the elimination of deleterious off-target effects.

144 lectrophilic bromination followed by thermal elimination of dibromine.

145 tions in incidence are possible, but without elimination of disparities in healthcare access, we foun

146 Elimination of distal CS to LA connections reduced atria

147 e of ethoxyphosphinidene, followed by formal elimination of ethanol yields 3,5-diphenyl-2-phosphafura

148 onventional microfluidic methods, namely the elimination of exterior influences including convection

149 otein muscleblind-like splicing regulator 1, elimination of foci of toxic RNA, reversal of splicing b

150 preferentially expose the CD4bs by selective elimination of glycosylation sites flanking the CD4bs, a

151 [L(Ph)Ni(I)(2)](-) intermediate 4 either via elimination of H(2) from dihydride 3 or via reductive C-

152 I)-H species undergoes bimolecular reductive elimination of H(2).

153 nal Sustainable Development Goals (SDGs) for elimination of hepatitis B virus (HBV) infection set amb

154 Elimination of HIV DNA from infected individuals remains

155 An HIV cure requires the elimination of HIV from every body compartment, but avai

156 servations offer a promising step toward the elimination of HIV reservoirs in the clinic.

157 ic complex, [{L}Y(N(SiMe(3))(2))(2)] (1), by elimination of HN(SiMe(3))(2).

158 apy trials, that can lead to minimization or elimination of immunosuppression and, it is hoped, help

159 include post-translational modifications and elimination of individual polypeptides.

160 TAV platform has the potential to enable the elimination of infected cells by redirecting endogenous

161 Elimination of infected cells was further quantified usi

162 romycin distributions may help achieve local elimination of infection.

163 l acute inflammatory response results in the elimination of infectious agents by neutrophils and mono

164 Due to the elimination of internal concentration polarization, the

165 These findings suggest that elimination of iTFA can cost-effectively improve health

166 HIV infection have focused primarily on the elimination of latently infected CD4(+) T cells.

167 leep in experience-dependent dendritic spine elimination of layer 5 pyramidal neurons in the visual (

168 arison of fitness between cells leads to the elimination of less competent cells in the presence of m

169 With new allocation change proposals and elimination of listing criteria for T2DM, further monito

170 The global elimination of lymphatic filariasis (LF) is a major focu

171 roved drug regimens are needed to accelerate elimination of lymphatic filariasis in Africa.

172 uced analog tafenoquine are required for the elimination of malaria.

173 capture therapy (BNCT) allows the selective elimination of malignant tumor cells without affecting h

174 ped Binner, a new tool for the discovery and elimination of many degenerate feature signals typically

175 chain of the Me(3)SiO group (followed by the elimination of Me(3)SiOH) and protonation of the thiophe

176 Despite the elimination of measles in the United States (US) in the

177 Elimination of mechanically induced myotonia by TRPV4 in

178 lar polysaccharide led to an almost complete elimination of MenA clinical cases.

179 Overall, we show that short-term elimination of microglia during the chronic phase of TBI

180 The elimination of mitochondria via autophagy, termed mitoph

181 rmation of 1H-2-(diazomethylene)pyridine and elimination of N(2) with a barrier of ca. 26 kcal/mol.

182 atment and overcomes a major obstacle to the elimination of onchocerciasis in areas coendemic for Loa

183 Importantly, direct elimination of one or more O-glycans under negative-mode

184 KLK6 levels and attenuated following genetic elimination of PAR1 but not PAR2.

185 As we could not rule out the elimination of past transposition increase signatures by

186 rend is influenced to a lesser extent by the elimination of PBDEs from the human body, e.g., differen

187 ure that is maintained after therapy-induced elimination of persistent infection and may constitute a

188 PIs provide efficient elimination of plasmablast-mediated humoral responses; h

189 Elimination of premisting (mixing of coolant water and a

190 In the past, unspecific elimination of ROS by use of low molecular mass antioxid

191 allows senescence to promote metastasis, and elimination of senescent cells with a senolytic BCL-2 in

192 (2020) show that elimination of solutes from the brain along arterial wal

193 and of the HA.antibody complex indicates the elimination of some sequence ions that originate from ba

194 The elimination of specific dietary cholesterol target recom

195 ) muLED optoelectrodes that enable effective elimination of stimulation artifact.

196 Microglia, through the elimination of supernumerary synapses, have an establish

197 Elimination of the FHL1-binding site in the nsP3 HVD can

198 of gem-difluoroalkenes through beta-fluoride elimination of the generated alpha-CF(3) carbanions.

199 Malaysia is approaching elimination of the human-only Plasmodium species.

200 Interestingly, elimination of the O-fucose site on EGF12 allowed LFNG t

201 vated via Ni C-H insertion, followed by beta elimination of the phenoxide leaving group.

202 n months protection and resulted in the near elimination of the primary malaria vector An. funestus a

203 active site cofactors are optimized for fast elimination of the toxic NO molecules.

204 BIAD1 in mice; however, homozygous germ-line elimination of the Ubiad1 gene caused embryonic lethalit

205 ference of Parties (COP-3) in November 2019, elimination of the use of dental amalgam in oral health

206 inst using extracorporeal methods to enhance elimination of these drugs in patients with severe chlor

207 Elimination of those factors might allow to increase acc

208 ion, a current unmet need toward the goal of elimination of transmission of O. volvulus.

209 Here, we show that the elimination of TRIM6 in human cells results in an increa

210 lenging strategy for the robust and specific elimination of tumor cells by cellular immunotherapy.

211 Rather, elimination of type I cytokine interferon-gamma activity

212 This enzyme is responsible for elimination of unconjugated bilirubin from the body by g

213 independence, and (in the patient with SCD) elimination of vaso-occlusive episodes.

214 The HCl promoted 1,4-elimination of water, whereas in the presence of BF(3).E

215 CYP2B6 is a vital enzyme for the metabolic elimination of xenobiotics, and it is prone to induction

216 Simultaneous elimination of YAP suppresses the cortical enlargement a

217 Global elimination of YF epidemics requires higher population-l

218 ks and vaccination efforts needed to achieve elimination of YF epidemics.

219 These results suggest that the elimination or mitigation of photoinduced electron trans

220 into the M-H bond, followed by P-C reductive elimination, or by insertion into the M-P bond and C-H r

221 -opening, metal-catalyzed C-C insertions and eliminations, oxidative fragmentation using hypervalent

222 rome P450 (CYP) enzymes can inhibit chemical elimination pathways and cause synergistic mixture effec

223 SLC22A6) and OAT3 (SLC22A8), the main kidney elimination pathways for many common drugs, are often co

224 de ionization and thereby circumvents simple elimination pathways.

225 s the country moves toward hepatitis B and C elimination, population-based estimates are necessary to

226 rmally decomposes to afford large amounts of elimination products together with iodoalkanols.

227 We conducted a nationwide HCV micro-elimination program among men who have sex with men (MSM

228 A systematic and population-based HCV micro-elimination program among MSM living with HIV was feasib

229 At the end of the micro-elimination program, 176/190 MSM (93%) were cured, and t

230 ia embarked on the world's first hepatitis C elimination program.

231 t, which makes this combination suitable for elimination protocols in resource-limited countries.

232 c MDA is not currently required for trachoma elimination purposes in these settings.

233 es were processed with the recursive feature elimination random forest classifier.

234 ular capsule Ga(4)L(6)(12-) on the reductive elimination reaction from gold complexes and assess thei

235 This reversible addition/elimination reaction of a single surface ligand on gold

236 e transition state to complete the reductive elimination reaction with greater catalytic efficiency.

237 itol was inaccessible due to an unusual beta-elimination reaction, wherein the azide anion acted as t

238 urface groups by performing substitution and elimination reactions in molten inorganic salts.

239 The C(sp(2))-X reductive elimination reactions of all isolated Pt(IV) complexes f

240 ov, electrophilic aromatic substitution, and elimination reactions) gave BC-1 (53% yield) along with

241 in good yields while minimizing deleterious elimination reactions.

242 nitor Cell Mobilization With Intensive Lipid Elimination Regimen) evaluated LDL apheresis in nonfamil

243 ia a Dieckmann cyclization and a retro-aldol elimination, releasing ammonia and D-erythronate-4-phosp

244 erein we show that BCG-induced bladder tumor elimination requires CD4 and CD8 T cells, although augme

245 Tuberculosis (TB) elimination requires innovative approaches.

246 ty RDT may have limited utility in a malaria elimination setting like Haiti.

247 al evaluation of RACD in Eswatini, a malaria elimination setting.

248 e amperometric detector performed after beta-elimination showed glucose as the major component in the

249 cient styrenes afford primarily beta-hydride elimination side reactivity.

250 Zn to promote a rate-limiting C-H reductive elimination step, and calculations attribute this to a s

251 s of the potential impacts of TB control and elimination strategies.

252 The WHO elimination strategy for hepatitis C virus advocates sca

253 UNAIDS' elimination strategy requires achieving a treatment cove

254 entury, successful implementation of the WHO elimination strategy would reduce cervical cancer mortal

255 In contrast to the elimination strategy, a containment strategy aims to mai

256 for monitoring gHAT elimination and for post-elimination surveillance.

257 decision makers of the likelihood that their elimination target has been met, and where to invest in

258 Organization's (WHO) hepatitis C virus (HCV) elimination target of an 80% reduction in incidence by 2

259 e of most impact in driving advances towards elimination targets at a population level.

260 vide additive impact in reaching control and elimination targets.

261 ther countries aiming to achieve the WHO HCV elimination targets.

262 With the increased interest in malaria elimination, TBV and monoclonal antibodies have moved to

263 idation (LPOCV) scheme and recursive feature elimination technique applied for feature selection.

264 ystems model developed on this scale for PHT elimination that maximizes the resolution of estimation

265 e consistent with unimolecular C-C reductive elimination that occurred either by a concerted pathway

266 The elimination thresholds examined were an average age-stan

267 perating characteristic curves for different elimination thresholds under various age-dependent expos

268 e the discriminatory power of serology-based elimination thresholds.

269 ilariae in the blood preclude onchocerciasis elimination through community-directed treatment with iv

270 ticular autophagic pathways, to prevent cell elimination through programmed death.

271 s we move into a period of potential disease elimination through the introduction of typhoid conjugat

272 elling study, we assessed the probability of elimination, time to elimination, and percentage of case

273 2-year rollout), reduced the probability of elimination to 0-95% and the proportion of cases averted

274 roceeds with chloride abstraction and alkane elimination to form the bis-cyclometalated derivatives [

275 ent with irreversible unimolecular reductive elimination to form the cyclobutane product.

276 that tissues co-opt neutrophils en route for elimination to induce programs that support their physio

277 that are cyclization and 1,2-H shift before elimination to persist the iterative cycle, but the reac

278 story suggests that we should expect typhoid elimination to take decades.

279 dihydroartemisinin-piperaquine as a malaria elimination tool in Southern Province.

280 hydrogen in the rate-limiting C-H reductive elimination transition states.

281 rs robust complement activation and ookinete elimination upon mosquito midgut traversal.

282 utic and diagnostic needs in the field of TB elimination using multidisciplinary, multisectorial appr

283 Recursive feature elimination using random forest (RFE-RF) was used to ide

284 o-DO accelerates turnover limiting reductive elimination via LUMO lowering.

285 irected [3 + 3] annulation involves sulfonyl elimination via O-S or C-S bond cleavage, affording 2-py

286 receptor subunit NR2 results in their rapid elimination via the TNF/Eiger>JNK signalling pathway, lo

287 20.56-19.15; P = .94), and odds ratio of OCS elimination was 2.26 (95% CI 0.52-9.84; P = .28).

288 Overall, DSA elimination was associated with increased posttransplant

289 Elimination was via the hepatobiliary and urinary system

290 cretory clearance for predicting kidney drug elimination, we evaluated stable outpatients with eGFRs

291 consolidate the successes of moving towards elimination, we need to understand the dynamics of trans

292 isk heterogeneity in communities approaching elimination, where few individuals disproportionately co

293 roteins 1 and 2-K are involved in mIBG renal elimination, whereas hOCT1 and hOCT3 may play important

294 of stable viral loads are followed by rapid elimination, which could be coupled with cytokine expans

295 is age group and advance the goal of malaria elimination, while weighing these benefits against poten

296 However, elimination will require additional tools.

297 lapses from dormant liver stages, its timely elimination will require widespread access to safe and e

298 ictors were identified via recursive feature elimination with random forest.

299 e new vector control could enable short-term elimination, with nearly all cases avoided for a decade

300 (WHO) member states have committed to global elimination, with targets to diagnose 90% of people livi