ライフサイエンスコーパス: empiric

1 and June, 2010, we did a randomised trial of empiric 14-day triple, 5-day concomitant, and 10-day seq

2 ainty for elemental diets, low certainty for empiric 2-, 4-, and 6-food elimination diets, and very l

3 : 2 methods using only clinical information (empiric 5 mg/day dosing and a formal clinical algorithm)

4 An empiric 6-food elimination diet effectively induced remi

5 Notably, an empiric 6-food elimination diet is as effective as a ski

6 An empiric 6-food elimination diet or removal of positive f

7 Three new models based on empiric AIS injury severities were developed.

8 signed (1:1) eligible participants to either empiric albendazole every 3 months plus praziquantel ann

9 we compared beta-lactams with vancomycin for empiric and definitive therapy of MSSA bloodstream infec

10 t is unclear if this association is true for empiric and definitive therapy.

11 Limiting empiric anti-gram-positive therapy to neutropenic patien

12 ard MTB diagnostic testing (24%) or received empiric anti-tuberculosis therapy (15%).

13 Determining when to use empiric anti-VRE antibiotic therapy in this population r

14 promising method of guiding rational use of empiric anti-VRE antimicrobial therapy in patients with

15 This study sought to examine the efficacy of empiric antiarrhythmic drugs in a rigorously characteriz

16 Hence, empiric antibiotic choice should reflect these trends.

17 o define if severity should be used to guide empiric antibiotic choices.

18 mmune response is altered by transient early empiric antibiotic exposure at birth.

19 fluoroquinolones were the most commonly used empiric antibiotic for ASB [245/691 (35%)].

20 cephalosporins (3GC) remain the first-choice empiric antibiotic for severe infection in many sub-Saha

21 Empiric antibiotic monotherapy is considered the standar

22 elines and decision-support tools to improve empiric antibiotic prescribing.

23 kelihood of coverage achieved by their usual empiric antibiotic regimen, along with minimum threshold

24 nario, participants selected their preferred empiric antibiotic regimen, estimated the likelihood of

25 could be considered as one of the first-line empiric antibiotic therapies.

26 Delays in empiric antibiotic therapy are associated with increased

27 llow, and </= one single intravenous dose of empiric antibiotic therapy before study drug treatment i

28 Empiric antibiotic therapy can be narrowly targeted at G

29 cultures are often considered when choosing empiric antibiotic therapy for a suspected urinary tract

30 d be considered by clinicians in prescribing empiric antibiotic therapy for CAP in immunocompromised

31 ons, should be understood both when choosing empiric antibiotic therapy for infectious keratitis and

32 study is to determine the rate of prolonged empiric antibiotic therapy in adult ICUs in the United S

33 amine the relationship between the prolonged empiric antibiotic therapy rate and certain ICU characte

34 of factors associated with the ICU prolonged empiric antibiotic therapy rate was conducted using Stud

35 Prolonged empiric antibiotic therapy rate was determined as the ra

36 was significantly associated with prolonged empiric antibiotic therapy rate.

37 iated pneumonia had lower rates of prolonged empiric antibiotic therapy than those that did not, 45.1

38 Prolonged empiric antibiotic therapy was defined as empiric antibi

39 nation of site of care, selection of initial empiric antibiotic therapy, and subsequent management de

40 ial treatment failure, but not inappropriate empiric antibiotic therapy, was a mortality risk factor

41 phylactic, definitive, empiric, or prolonged empiric antibiotic therapy.

42 However, they are scarcely used for empiric antibiotic therapy.

43 iagnosis, and support the discontinuation of empiric antibiotic therapy.

44 ill patients routinely receive vancomycin as empiric antibiotic therapy.

45 s are more likely to result in inappropriate empiric antibiotic therapy.

46 To prevent inappropriate empiric antibiotic treatment in patients with bacteremia

47 or threshold values result in evaluation and empiric antibiotic treatment of large numbers of uninfec

48 pneumonia accounted for approximately 60% of empiric antibiotic use.

49 FUBC, unless bacteria were not sensitive to empiric antibiotic.

50 .0 degrees C 72 to 96 hours after receipt of empiric antibiotics (NBL group: 22.7% vs BL group: 13.9%

51 termined as the ratio of the total number of empiric antibiotics continued for at least 72 hours divi

52 The time to empiric antibiotics did not differ significantly, but op

53 for particulate aspiration, consideration of empiric antibiotics for pneumonia treatment, and lower r

54 The choice of empiric antibiotics for the treatment of gram-negative b

55 comycin and ceftazidime seem to be excellent empiric antibiotics for treating endophthalmitis.

56 These findings impact the choice of empiric antibiotics in critically ill burn patients.

57 widespread practice of a prolonged course of empiric antibiotics in patients with presumed CRS.

58 h infectious diseases, limiting the need for empiric antibiotics in this age group.

59 Early administration of appropriate empiric antibiotics is essential for achieving the best

60 Half of all empiric antibiotics ordered in critically ill patients a

61 classified as BL or NBL groups based on the empiric antibiotics received.

62 ed empiric antibiotic therapy was defined as empiric antibiotics that continued for at least 72 hours

63 Empiric antibiotics upon development of hematoma did not

64 The most frequently prescribed empiric antibiotics were vancomycin and piperacillin/taz

65 lance the need for administering appropriate empiric antibiotics while also minimizing the use of cli

66 ng management (modification and cessation of empiric antibiotics), and empiric antifungal treatment (

67 Of the empiric antibiotics, 333 of 660 (50%) were continued for

68 Empiric antibiotics, antivirals, and antifungals were ad

69 everity of acute illness, appropriateness of empiric antibiotics, ICU placement, tracheostomy-depende

70 everity of acute illness, appropriateness of empiric antibiotics, intensive care unit placement, trac

71 es of common bundle components such as early empiric antibiotics, weight-based fluid administration,

72 assessed 72 to 96 hours after initiation of empiric antibiotics.

73 east 72 hours divided by the total number of empiric antibiotics.

74 ibiotic resistance is important in selecting empiric antibiotics.

75 ng/mL (sensitivity 95%, specificity 46%) and empiric anticoagulation considered if D-dimer is greater

76 Empiric antifibrinolytics for children should be questio

77 IA) has the potential to decrease the use of empiric antifungal agents.

78 ctions (9 vs 17; P = .09), and less frequent empiric antifungal therapy (24.1% vs 30.2%, P = .11) wit

79 ntext of intensive monitoring and structured empiric antifungal therapy, 6-month FFS and overall surv

80 nitial presentation, ongoing management, and empiric antifungal therapy.

81 n and cessation of empiric antibiotics), and empiric antifungal treatment (risk stratification, evalu

82 for diagnosis, laboratory investigation, and empiric antimicrobial and adjunctive therapy were develo

83 recent antibiotic exposure when formulating empiric antimicrobial regimens for suspected Gram-negati

84 We examined the impact of initial empiric antimicrobial therapeutic variables on the hospi

85 orm clinicians regarding the best choice for empiric antimicrobial therapy against this multidrug-res

86 the relationship between aspects of initial empiric antimicrobial therapy and mortality in patients

87 Empiric antimicrobial therapy for healthcare-acquired in

88 e process of selection and implementation of empiric antimicrobial therapy in this high-risk group sh

89 Timely empiric antimicrobial therapy is associated with improve

90 nappropriate and delayed appropriate initial empiric antimicrobial therapy is associated with increas

91 al data may inform prevention strategies and empiric antimicrobial therapy selection.

92 Practices for antimicrobial prophylaxis and empiric antimicrobial therapy should be regularly assess

93 Inappropriate initial empiric antimicrobial therapy was administered in 155 (2

94 Symptoms progressed despite empiric antimicrobial therapy, and the patient died afte

95 s, should be taken into account in selecting empiric antimicrobial treatment.

96 analyses suggest that improved targeting of empiric antimicrobials for multidrug-resistant bacteria,

97 verage of these organisms when administering empiric antimicrobials for sepsis.

98 gan failures, bacteremia, appropriateness of empiric antimicrobials, or adjunct therapies.

99 Empiric antimycotic prophylaxis initiated at the time of

100 Early empiric antiviral treatment is recommended for those wit

101 on holds the promise of rational rather than empiric approaches for the treatment of cancer patients.

102 environment interactions were examined using empiric Bayes-mediated linear models.

103 RMD platforms can help inform empiric beta-lactam therapy in cases where bla genes are

104 With widespread empiric broad-spectrum beta-lactam use creating selectiv

105 or 60-day adverse renal outcomes than other empiric broad-spectrum combinations.

106 Therapy remains, for the most part, empiric but must be ever mindful of the potential risks

107 estimated collision cross sections using an empiric calibration method.

108 patients receiving empiric PTZ compared with empiric carbapenem therapy (95% confidence interval, 1.0

109 ll, 335 patients were included; 249 received empiric carbapenems and 86 OADs.

110 sease where systemic therapy has relied upon empiric chemotherapy despite the presence of genomic alt

111 Empiric chemotherapy with albendazole was instituted and

112 Empiric circumferential pulmonary vein isolation (CPVI)

113 ge drug development and mitigate against the empiric combination of such drugs outside of a clinical

114 of 689 primary prevention patients from the EMPIRIC (Comparison of Empiric to Physician-Tailored Pro

115 against the use of stimulant medications or empiric continuous positive airway pressure to reduce dr

116 ildren with NS are typically treated with an empiric course of glucocorticoid (Gc) therapy; a class o

117 d durations of therapy rather than the brief empiric courses often used in the ICU.

118 four pathogens that are not part of routine empiric coverage (e.g., Staphylococcus aureus, Pseudomon

119 The map will enable empiric coverage estimates and multipoint linkage analys

120 However, the empiric cumulative distribution functions of the qPET va

121 Empiric cumulative distribution functions of the qPET va

122 mpares favorably with previous results using empiric CUP regimens.

123 n cancer-specific therapies than they did to empiric CUP therapy with taxane/platinum regimens.

124 An empiric cutoff of more than 20% of PR-positive tumor cel

125 The patterns observed in the empiric data could be reproduced.

126 mbined ancestral sequence reconstruction and empiric deconstruction to unravel a gradual evolutionary

127 timal because these definitions are based on empiric description of occurrences that are merely assoc

128 ces and the (18)F-FDG sources allowed for an empiric determination of the relative response for these

129 Our findings do not suggest an effect of empiric deworming in the delaying of HIV disease progres

130 We aimed to assess the efficacy of empiric deworming of adults with HIV in delaying HIV dis

131 tions have a higher failure rate compared to empiric diet elimination.

132 tification of a majority of responders to an empiric diet with few food triggers, avoiding unnecessar

133 nalysis of five cancer genomes and performed empiric distribution fitting to examine the true distrib

134 may be useful in determining the utility of empiric donor pretreatment with low-dose dopamine.

135 In a clinical trial, an empiric dose of octreotide treatment prolonged time to t

136 algorithm (52%) than with all other methods: empiric dosing (37%; odds ratio [OR]: 2.2), clinical alg

137 c tables predicted warfarin dose better than empiric dosing, formal pharmacogenetic algorithms were t

138 rgy testing-directed elimination diet and an empiric elimination diet based on common food allergens.

139 and endoscopies limit the implementation of empiric elimination diets in patients with eosinophilic

140 -directed elimination diets, and nondirected empiric elimination diets.

141 ared with either allergy testing-directed or empiric elimination diets.

142 emoval of foods identified on SPTs/APTs plus empiric elimination of milk leads to resolution in 77% o

143 trials have indicated that less-restrictive, empiric, elimination diets can be effective and reduce t

144 red carefully because there was only limited empiric evidence for several input parameters.

145 Empiric evidence on safety threats and resilience in sur

146 ically in the treatment of ICDs, there is no empiric evidence supporting their use in PD.

147 are and severe zoonotic illness with limited empiric evidence to support treatment recommendations.

148 Although empiric exclusion from the diet of the 6 food groups mos

149 Empiric first and second-line triple treatments have una

150 to support the current practice of switching empiric first-line antibiotic when resistance exceeds 5%

151 n Gram-negative pathogens' resistance to all empiric first-line antimicrobials.

152 d pretreatment and after 3, 6, and 9 days of empiric first-line therapy.

153 resistance of Gram-negative pathogens to all empiric, first-line antimicrobials (ampicillin/penicilli

154 -differentiated TC treated with (131)I by an empiric fixed activity of 3.7 GBq at Gustave Roussy (GR,

155 -differentiated TC treated with (131)I by an empiric fixed activity of 3.7 GBq at Gustave Roussy (GR,

156 Use of an empiric fixed dose of 750 mg of daptomycin is predicted

157 provided no OS advantage when compared with empiric fixed RAI activity in the management of thyroid

158 provided no OS advantage when compared with empiric fixed RAI activity in the management of thyroid

159 lso made conditional recommendations against empiric food avoidance, upper gastrointestinal radiograp

160 sizes on system resolution and extended the empiric formula for reconstructed image resolution of co

161 riaxone, the last antibiotic recommended for empiric gonorrhea treatment, poses an urgent public heal

162 least partially affected by the adequacy of empiric gram-negative antimicrobial therapy.

163 Basing empiric HCAP therapy on its severity and the presence of

164 ents with SLE have been managed largely with empiric immunosuppressive therapies, which are associate

165 les (3GC-R-BSI) leads to a trade-off between empiric inappropriate treatment (IAT) and unnecessary ca

166 precalculated (177)Lu voxel S values and an empiric kidney half-life.

167 lts; from 2/2017-10/2018 recipients received empiric levofloxacin and azithromycin at transplant unti

168 epidemiologic shift has implications for the empiric management of community-associated infection whe

169 ty percent of the data was used to derive an empiric measure of severity of each of the 1322 injuries

170 Empiric measures of injury severity for each of the trau

171 o extract how biomolecules interact.The text empirics method that was investigated, though arising fr

172 uses 6.4 year observations and an ostensibly empiric methodology to predict low lifetime risks for no

173 egion was examined, as estimated by using an empiric model and baseline occupation and leisure activi

174 n the basis of these individual doses and on empiric models of radiation-induced cell death (i.e., re

175 c to Physician-Tailored Programming of ICDs [EMPIRIC], Multicenter Automatic Defibrillator Implantati

176 is and effective management of tuberculosis, empiric multidrug treatment is initiated in almost all s

177 ients to surgery or imaging surveillance and empiric nephron-sparing surgery.

178 ere categorized as prophylactic, definitive, empiric, or prolonged empiric antibiotic therapy.

179 also found of linkage to refraction on 7q36 (empiric P = 2.32 x 10(-3)), a region previously linked t

180 to 22q11 of adjusted refraction and myopia (empiric P = 4.43 x 10(-3) and 1.48 x 10(-3), respectivel

181 d for hyperopia on chromosome 3, region q26 (empiric P = 5.34 x 10(-4)), a region that had shown sign

182 3), respectively) and to 7p15 of refraction (empiric P = 9.43 x 10(-4)).

183 7300539; P(nominal) [P(n)] = 2.6 x 10(-8); P(empiric) [P(e)] = 0.0005 and rs822387; P(n) = 3.8 x 10(-

184 We determine whether the empiric pattern could be reproduced by a simple model, a

185 An empiric perspective on what epidemiology has studied ove

186 and should be considered as new policies for empiric pneumonia management are developed.

187 Empiric prescribing of antimicrobials in typhoid-endemic

188 ance, did not significantly reduce excessive empiric prescription of MRSA-active antibiotics despite

189 abnormal test locations with total deviation empiric probability plots in glaucoma patients, we compa

190 was 1.92 times higher for patients receiving empiric PTZ compared with empiric carbapenem therapy (95

191 Empiric quantification of human mobility patterns is par

192 However, many empiric questions about how best to structure and implem

193 The findings raise the possibility that empiric reductions in immunosuppressive therapy for all

194 The precise empiric regimen is determined by assessing patient and e

195 8% of patients were treated with an inactive empiric regimen.

196 e risks and benefits of AP-BL when selecting empiric regimens.

197 hilia in a similar proportion of patients as empiric removal of foods but required that fewer foods b

198 s that affords protection and the support of empiric research is critical.

199 at appropriateness is a logical extension of empiric research, which has revealed substantial variati

200 ient specific characteristics that can guide empiric selection are needed.

201 on is required if we hope to transition from empiric selection of therapeutics to risk-based, biology

202 ult eosinophilic oesophagitis (EoE), whereas empiric six-food elimination diet (SFED) achieves an eff

203 utively demonstrated to trigger EoE after an empiric six-food elimination diet-based study protocol a

204 We recommend the following empiric sorafenib starting doses by cohort: cohort 1, 40

205 However, this empiric strategy is not always successful.

206 This observation is supported by the empiric studies in pathophysiology and controlled labora

207 y-adjusted life expectancy (4 days) than did empiric surgery at a lower lifetime cost ($3466), domina

208 sholds at which screening ultrasound or even empiric systemic anticoagulation is indicated.

209 ells/uL) at ART initiation to receive either empiric TB treatment or isoniazid preventive therapy (IP

210 ells/uL) at ART initiation to receive either empiric TB treatment or isoniazid preventive therapy (IP

211 use of insufficient powering, differences in empiric TB treatment rates, and disease severity between

212 accuracy of standard algorithms for initial empiric TB treatment, contact investigation, and housing

213 Fifty-nine (38%) received empiric TB treatment.

214 perative randomized clinical trials based on empiric therapeutic strategies.

215 prophylaxis > 24 hours (17.7%), overly broad empiric therapy (11.2%), and unnecessary treatment (11.0

216 compared with that in patients who received empiric therapy (hazard ratio [HR] 3.24, p=0.0051 [95% C

217 usly considered by clinicians to aid correct empiric therapy and to potentially reduce antibiotic mis

218 s of organs with Ureaplasma spp who received empiric therapy did not develop HS.

219 d extragenital contact after sexual assault; empiric therapy for gonorrhea, chlamydia, and trichomoni

220 t or 10-day sequential four-drug regimens as empiric therapy for H pylori infection in diverse Latin

221 Optimal empiric therapy for hospitalized patients with healthcar

222 Choice of empiric therapy for pneumonia depends on risk for antimi

223 ed 14-day mortality of PTZ vs carbapenems as empiric therapy in a cohort of patients with ESBL bacter

224 s) have the potential to inform selection of empiric therapy in patients infected by P. aeruginosa.

225 etermine the risks and benefits of prolonged empiric therapy in the critically ill.

226 nic therapy in those unresponsive to initial empiric therapy is discouraged.

227 eters remain essential for TBM diagnosis and empiric therapy is often needed.

228 coverage and, as such, may be considered for empiric therapy of endophthalmitis caused by yeast or mo

229 of 660 unique antibiotics were prescribed as empiric therapy to 364 patients.

230 Inappropriate empiric therapy was associated with an increased risk of

231 Empiric therapy was defined as starting treatment 2 days

232 hea therapies, suggesting that resistance to empiric therapy was not a main driver of spread, even as

233 Patients who received empiric therapy with a beta-lactam had similar mortality

234 ermine the cost-effectiveness of appropriate empiric therapy with broad-spectrum agents active agains

235 ion in whom blood cultures were obtained and empiric therapy with broad-spectrum beta-lactams and/or

236 Empiric therapy with OADs was not associated with mortal

237 patients with BSI due to ESBL-E who received empiric therapy with such drugs (other active drugs [OAD

238 immunoglobulins (IVIG) have been used as an empiric therapy without proof of effectiveness.

239 For empiric therapy, 474 (94%) IDC and 297 (87%) NIDC patien

240 diagnosis is one of the primary reasons for empiric therapy, and diagnostic methods that enable rapi

241 ion allows more options to be considered for empiric therapy, at least for some patients, depending o

242 In empiric therapy, ciprofloxacin was the first choice of d

243 The primary exposure was empiric therapy, defined as antibiotic therapy administe

244 istance represent a promising alternative to empiric therapy, reducing inappropriate antibiotic use.

245 in if penicillin allergic) is recommended as empiric therapy, unless fluoroquinolone prophylaxis was

246 ithm, with only 53% receiving broad-spectrum empiric therapy, yet 92.9% received appropriate therapy

247 ophylaxis and diagnostic-based preemptive or empiric therapy.

248 hospitalized patients, both as directed and empiric therapy.

249 tric sepsis, but minimal data exist to guide empiric therapy.

250 The ongoing transition from empiric to molecular medicine has engendered a need for

251 lusion criteria; 4 randomized (Comparison of Empiric to Physician-Tailored Programming of ICDs [EMPIR

252 ion patients from the EMPIRIC (Comparison of Empiric to Physician-Tailored Programming of Implantable

253 ive microbiology resulted in less changes of empiric treatment (33 [40%] vs 112 [60%]; p=0.005) and s

254 s among all isolates with the following: (1) empiric treatment (B and C), and treatment guided by POC

255 nosed with a stepwise approach incorporating empiric treatment and antisecretory therapy, combined MI

256 instructed versus induced patients initiated empiric treatment based on clinical and radiography find

257 se) to guide treatment changes compared with empiric treatment changes, and the benefits and risks of

258 ity and mortality make early recognition and empiric treatment critical.

259 l of the benefits and risks that result from empiric treatment decisions that are based on resistance

260 st step in bridging the gap between RMDs and empiric treatment decisions.

261 In patients receiving empiric treatment for sepsis, prior colonization with 3G

262 children and should prompt consideration of empiric treatment for SFR when present.

263 children, and should prompt consideration of empiric treatment for SFR when present.

264 idime-avibactam was highly effective for the empiric treatment of cUTI (including acute pyelonephriti

265 For empiric treatment of febrile dysenteric diarrhea invasiv

266 e to beta-lactam agents commonly used in the empiric treatment of febrile neutropenia was observed on

267 lness with no laboratory-confirmed etiology, empiric treatment of iNTS disease is a major challenge i

268 tance to 4 beta-lactams commonly used in the empiric treatment of neutropenic fever.

269 cological principles will help guide optimal empiric treatment of outpatient UTIs.

270 nerally is the recommendation as the initial empiric treatment of suspected bacterial endophthalmitis

271 to adapt therapy in patients unresponsive to empiric treatment options, which occurs in 10% of all ca

272 prophylaxis regimens, programs should devise empiric treatment regimens that are directed against the

273 s (LBCLs) with inferior responses to current empiric treatment regimens.

274 Empiric treatment should be considered for ELBW infants

275 tigations led to revised recommendations for empiric treatment strategies and additional management d

276 erratically and, instead, clinicians rely on empiric treatment strategies and ignore public health im

277 h to determine the appropriate threshold for empiric treatment when PE is suspected before diagnostic

278 We were unable to show that empiric treatment with OAD was associated with a worse o

279 patients with BSI due to ESBL-E who received empiric treatment with OADs or carbapenems was performed

280 Continued empiric treatment without POC testing was projected to r

281 tential clinical and public health impact on empiric treatment, contact investigation, and housing in

282 duce the frequency and impact of unnecessary empiric treatment, contact investigation, and housing, p

283 ame-day diagnoses, and-because of widespread empiric treatment-may not result in more patients starti

284 ancomycin for definitive therapy but not for empiric treatment.

285 of guideline adherence on appropriateness of empiric treatment.

286 e often lacking, leading to the necessity of empiric treatment.

287 rent asthma subtypes into a single group for empiric treatment.

288 The mainstay empiric treatments of bacterial endophthalmitis are intr

289 eflux disease (GERD) commonly starts with an empiric trial of proton pump inhibitor (PPI) therapy and

290 Empiric trial using proton pump inhibitors is still the

291 need to be taken into account when designing empiric trials to determine appropriate blood pressure t

292 Empiric triple treatments for Helicobacter pylori (H. py

293 ntibody-mediated rejection (biopsy proven or empiric), two patients (12%) lost their graft by 1 year.

294 elusive, current therapeutic strategies are empiric, unfocused and often unsatisfactory.

295 streptococci (VGS) is a major factor driving empiric use of an anti-gram-positive antimicrobial in pa

296 Empiric use of antibiotics not specific for B. pseudomal

297 ion of an intensivist-led model of care, the empiric use of meropenem, and adjunctive treatment with

298 cultures in our series, suggesting that the empiric use of vancomycin in the setting of severe suspe

299 r vaccine YF-17D, one of the most successful empiric vaccines ever developed, activates dendritic cel

300 re starting thiopurine therapy compared with empiric weight-based dosing and explores the performance