ライフサイエンスコーパス: enamel matrix

1 s the major protein component of the forming enamel matrix.

2 ses) and to the newly secreted extracellular enamel matrix.

3 ndary revealed the "fish net" pattern of the enamel matrix.

4 se in EMSP1 activity in the transition-stage enamel matrix.

5 proteins constituting most of the developing enamel matrix.

6 est amounts of ameloblastin were detected in enamel matrix.

7 hanges in the constituents of the developing enamel matrix.

8 hers on similar structures in the developing enamel matrix.

9 ntrolled changes to the pH of the developing enamel matrix.

10 sported from ameloblasts into the developing enamel matrix.

11 this is also when MMP20 is secreted into the enamel matrix.

12 y disrupting normal protein removal from the enamel matrix.

13 results in acidification of the mineralizing enamel matrix.

14 ns as the structural scaffolds in developing enamel matrix.

15 ay serve several functional roles within the enamel matrix.

16 nsists of the amelogenin fraction of porcine enamel matrix (AMEL) suspended in a vehicle of propylene

17 lasts and activated promoter activity of the enamel matrix ameloblastin gene.

18 the proteinase from porcine transition-stage enamel matrix and characterized it by partial protein se

19 ss amelogenin properly, possesses an altered enamel matrix and rod pattern, has hypoplastic enamel th

20 le proteinases are present in the developing enamel matrix, and the precise role of enamelysin in the

21 transcripts containing exon4 (AMG+4) in the enamel matrix, and the relative binding of recombinant A

22 The components of the developing enamel matrix are generally specific for that matrix.

23 ese findings constrain the emerging model of enamel matrix assembly by helping to define the limits o

24 d that AMG+4 proteins were secreted into the enamel matrix at the early maturation stage.

25 racterised by near-normal volumes of organic enamel matrix but with weak, creamy-brown opaque enamel

26 aturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel form

27 ion results in a release of protons into the enamel matrix, causing an acidification of the local mic

28 ally substitute for C/EBPalpha to produce an enamel matrix competent to direct biomineralization.

29 This may suggest that either another enamel matrix component in EMD may be responsible for so

30 olars revealed reductions in early expressed enamel matrix components (Odontogenic ameloblast-associa

31 t requires a combined interaction with other enamel matrix components of EMD to direct the regenerati

32 ible for the transportation and secretion of enamel matrix components, and proteases processing ename

33 x serine proteinase 1, an enzyme involved in enamel matrix degradation and with a putative role in th

34 ture of specialized proteins, the developing enamel matrix (DEM).

35 d bone allograft (DFDBA) in combination with enamel matrix derivative (EMD + DFDBA) compared to ename

36 rafts (ADMG) + CAF and SCTG + CAF or between enamel matrix derivative (EMD) + CAF and SCTG + CAF.

37 clinical trial was that local application of enamel matrix derivative (EMD) added to papilla reflecti

38 matrix derivative (EMD + DFDBA) compared to enamel matrix derivative (EMD) alone in the treatment of

39 Enamel matrix derivative (EMD) and autologous fibrinogen

40 fect morphology for combination therapy with enamel matrix derivative (EMD) and bone grafting.

41 Enamel matrix derivative (EMD) and collagen membranes (C

42 The use of various combinations of enamel matrix derivative (EMD) and grafting materials ha

43 periodontal surgery using the combination of enamel matrix derivative (EMD) and natural bone mineral

44 ly autogenous blood-dervied products (ABPs), enamel matrix derivative (EMD) and recombinant human pla

45 Enamel matrix derivative (EMD) and recombinant human pla

46 Connective tissue graft (CTG) and enamel matrix derivative (EMD) approaches provided super

47 The mechanisms of action of enamel matrix derivative (EMD) are poorly understood, an

48 In this study, the effect of using an enamel matrix derivative (EMD) as an adjunct to non-surg

49 In this study, we compare the effects of enamel matrix derivative (EMD) associated with a hydroxy

50 this study, we compare the effectiveness of enamel matrix derivative (EMD) associated with a simplif

51 sidering xenogeneic collagen matrix (CM) and enamel matrix derivative (EMD) characteristics, it is su

52 s study was to evaluate the effectiveness of enamel matrix derivative (EMD) combined with a bovine-de

53 ctice reports on the clinical efficacy of an enamel matrix derivative (EMD) combined with either demi

54 Enamel matrix derivative (EMD) contains a variety of hyd

55 The enamel matrix derivative (EMD) contains hundreds of pept

56 ally, the use of collagen matrix (CM) and/or enamel matrix derivative (EMD) for the treatment of dehi

57 Porcine enamel matrix derivative (EMD) has a clinical use in fac

58 Enamel matrix derivative (EMD) has an extensive document

59 Enamel matrix derivative (EMD) has been developed as a s

60 The enamel matrix derivative (EMD) has been recently introdu

61 The use of an enamel matrix derivative (EMD) has been shown to enhance

62 Enamel matrix derivative (EMD) has been shown to promote

63 Enamel matrix derivative (EMD) has been shown to promote

64 The clinical use of an enamel matrix derivative (EMD) has been shown to promote

65 In periodontal therapy enamel matrix derivative (EMD) has been successfully use

66 Recently, enamel matrix derivative (EMD) has been the subject of s

67 Enamel matrix derivative (EMD) has been used in periodon

68 Although enamel matrix derivative (EMD) has been used to promote

69 Although enamel matrix derivative (EMD) has demonstrated the abil

70 Previous studies have demonstrated that enamel matrix derivative (EMD) has the ability to improv

71 Previous studies have demonstrated that enamel matrix derivative (EMD) has the ability to improv

72 ized freeze-dried bone allograft (DFDBA) and enamel matrix derivative (EMD) have been used with varyi

73 ith a xenogenous collagen matrix (CM) and/or enamel matrix derivative (EMD) in combination with a cor

74 Acellular dermal matrix graft (ADMG) or enamel matrix derivative (EMD) in conjunction with a cor

75 nnective tissue graft (CTG) with and without enamel matrix derivative (EMD) in the treatment of multi

76 he large body of evidence on the efficacy of enamel matrix derivative (EMD) in the treatment of perio

77 he large body of evidence on the efficacy of enamel matrix derivative (EMD) in the treatment of perio

78 Enamel matrix derivative (EMD) is a composite of protein

79 Enamel matrix derivative (EMD) is commonly used in perio

80 Enamel matrix derivative (EMD) is suggested to stimulate

81 Enamel matrix derivative (EMD) is used during periodonta

82 this study was to determine the effect of an enamel matrix derivative (EMD) on cementoblast behavior

83 cemento-inductivity effect of calcitriol and enamel matrix derivative (EMD) on human periodontal liga

84 of this study is to determine the impact of enamel matrix derivative (EMD) on superoxide (O(2)(-)) g

85 ellular dermal matrix (ADM) with and without enamel matrix derivative (EMD) on the percentage of root

86 radiographic and patient-centered results of enamel matrix derivative (EMD) therapy in intrabony defe

87 have been demonstrated with the addition of enamel matrix derivative (EMD) to demineralized freeze-d

88 Porcine fetal enamel matrix derivative (EMD) was implanted bilaterally

89 After surgical debridement, enamel matrix derivative (EMD) was placed into the bony

90 Enamel matrix derivative (EMD) was shown to enhance soft

91 neutral ethylene diamine tetracetic acid and enamel matrix derivative (EMD) were first used to treat

92 Use of enamel matrix derivative (EMD) when dealing with non-con

93 modality as compared with the association of enamel matrix derivative (EMD) with ABG in the managemen

94 milarly, in guided tissue regeneration (GTR)/enamel matrix derivative (EMD) with and without laser tr

95 inical studies suggest that a combination of enamel matrix derivative (EMD) with demineralized freeze

96 have also demonstrated the efficacy of using enamel matrix derivative (EMD) with demineralized freeze

97 of periodontal regeneration treatments with enamel matrix derivative (EMD), a commercial formulation

98 ontaining different concentrations of either enamel matrix derivative (EMD), amelogenin, platelet-der

99 of autologous blood-derived products (ABPs), enamel matrix derivative (EMD), recombinant human platel

100 of autologous blood-derived products (ABPs), enamel matrix derivative (EMD), recombinant human platel

101 m of this study is to evaluate the effect of enamel matrix derivative (EMD), tyrosine-rich amelogenin

102 onally advanced flaps (CAF) with and without enamel matrix derivative (EMD).

103 ward regeneration in infrabony defects using enamel matrix derivative (EMD).

104 e graft and the coronally advanced flap with enamel matrix derivative (EMD).

105 es of osteogenic maturation to porcine fetal enamel matrix derivative (EMD).

106 resolution in intrabony defects treated with enamel matrix derivative (EMD).

107 good outcomes have also been obtained using enamel matrix derivative (EMD).

108 logenin fraction of porcine enamel matrix in enamel matrix derivative (i.e., AMEL) is not antibacteri

109 enic (bone morphogenetic protein [BMP]-2 and enamel matrix derivative [EMD]) were compared to a contr

110 In summary, the combination of enamel matrix derivative and autogenous bone represents

111 1) Biologics (enamel matrix derivative and recombinant human platelet-

112 xenograft used alone and in combination with enamel matrix derivative are effective for the treatment

113 h >/= 4 mm) was treated regeneratively using enamel matrix derivative at two centers (Frankfurt am Ma

114 from the same surgical site was treated with enamel matrix derivative in a dampen dish and then added

115 n enhancement of hard tissue parameters when enamel matrix derivative is added to demineralized freez

116 ort the concept that clinical application of enamel matrix derivative may enhance periodontal wound r

117 Adjunctive autologous bone grafting with enamel matrix derivative might be significantly benefici

118 tudy was to compare the clinical efficacy of enamel matrix derivative placed under a coronally advanc

119 The combination of enamel matrix derivative plus autogenous bone graft stim

120 cept for MRC at the 12-month follow-up where enamel matrix derivative plus CAF exhibited superior res

121 ve tissue grafts (SCTGs), matrix grafts, and enamel matrix derivative protein (EMD) procedures were s

122 A recent study suggests that the addition of enamel matrix derivative to demineralized freeze-dried b

123 he results of this study, the application of enamel matrix derivative to denuded root surfaces receiv

124 of a commercially prepared embryonic porcine enamel matrix derivative to induce new bone formation in

125 Enamel matrix derivative was reconstituted and applied t

126 ized freeze-dried bone allograft (DFDBA), or enamel matrix derivative with or without DFDBA.

127 se histologic sections strongly suggest that enamel matrix derivative works in a biomimetic fashion b

128 h a bone replacement graft [combination], or enamel matrix derivative), according to predefined crite

129 rformed utilizing water-jet decontamination, enamel matrix derivative, and locally harvested autogeno

130 utilizing collagen membrane, with or without enamel matrix derivative, can be successfully used in ob

131 ed flap plus acellular dermal matrix grafts, enamel matrix derivative, or collagen matrix led to the

132 ogics in root coverage procedures, including enamel matrix derivative, platelet-derived growth factor

133 and were not directly related to the use of enamel matrix derivative.

134 ly autologous blood-derived products (ABPs), enamel matrix derivatives (EMD) and recombinant human pl

135 Enamel matrix derivatives (EMDs) have been used in perio

136 Enamel matrix derivatives (EMDs) have demonstrated proof

137 ins, known to be present in some mixtures of enamel matrix derivatives.

138 cle cells and to determine the effects of an enamel matrix-derived protein (EMD) on these cells.

139 n the pH range that occurs in the developing enamel matrix during amelogenesis.

140 f ameloblastin in the ameloblasts and in the enamel matrix during different postnatal (PN) days (days

141 (37, 55, and 66 kDa) in both ameloblasts and enamel matrix during PN development.

142 enting unwanted mineral formation within the enamel matrix during the secretory stage of amelogenesis

143 in parallel to their role in the developing enamel matrix, ERPs have retained an evolutionary conser

144 ecific gene product that may be important in enamel matrix formation and mineralization.

145 Mutations in genes critical to enamel matrix formation have been documented, but curren

146 ovide novel strategies for the regulation of enamel matrix formation.

147 ger isoforms (55 and 66 kDa) appeared in the enamel matrix from day 3 onward.

148 8.9 +/- 11.5); and the 10 sites treated with enamel matrix gained on average 5.9 +/- 1.5 mm of CAL (C

149 asts secrete amelogenins on the pre-existing enamel matrix glycoproteins at the dentine-enamel juncti

150 ypothesis that amelogenins may interact with enamel matrix glycoproteins is tested by hemagglutinatio

151 The amelogenin fraction of porcine enamel matrix in enamel matrix derivative (i.e., AMEL) i

152 The developing enamel matrix is a highly dynamic system mainly composed

153 ed, hypomineralized, and protein-rich if the enamel matrix is not completely removed.

154 -length amelogenin protein in the developing enamel matrix, loss of ameloblast phenotype, increased a

155 ll adhesion, ameloblast differentiation, and enamel matrix mineralization.

156 ting impaired ameloblast differentiation and enamel matrix mineralization.

157 most abundant non-amelogenin proteins in the enamel matrix of developing teeth.

158 y stage and can readily be isolated from the enamel matrix of developing teeth.

159 Enamelin is the largest protein in the enamel matrix of developing teeth.

160 hesize that abnormal extracellular pH in the enamel matrix of mice with the cystic fibrosis gene knoc

161 reveal that enamelin is essential for proper enamel matrix organization and mineralization.

162 The enamel matrix pH during amelogenesis was studied in 10 n

163 idification while still leading to defective enamel matrix pH extracellularly. We identify a vesicle

164 The normal mouse enamel matrix pH was generally higher and modulated diff

165 determine their relationship with endogenous enamel matrix protein (amelogenin).

166 The correct spatiotemporal patterning of enamel matrix protein (EMP) expression is fundamental to

167 meloblastin (AMBN), the second most abundant enamel matrix protein (EMP), plays a critical role in am

168 nin (AMELX) is the predominant extracellular enamel matrix protein and plays an essential role in ena

169 Enamel matrix protein derivative (EMD) and particulate a

170 eatment of intrabony defects treated with an enamel matrix protein derivative (EMD) combined with eit

171 Multiple exposures to enamel matrix protein derivative (EMD) during periodonta

172 ine bone mineral (DBBM) combined with either enamel matrix protein derivative (EMD) or collagen membr

173 Enamel matrix protein derived from embryonic porcine too

174 loblastin (AMBN) is the second most abundant enamel matrix protein expressed during amelogenesis.

175 Enamel matrix protein expression was remarkably downregu

176 In general, enamel matrix protein treatment resulted in greater tiss

177 mm defects, the height of new cementum with enamel matrix protein treatment was 45% greater than the

178 Recently, a cDNA clone for an enamel matrix protein, ameloblastin (AMBN), has been iso

179 Mutations in ENAM, which encodes the largest enamel matrix protein, enamelin, have been demonstrated

180 Ameloblastin, an enamel matrix protein, is expressed by differentiating a

181 Amelogenin, the major extracellular enamel matrix protein, plays critical roles in controlli

182 assembly by helping to define the limits of enamel matrix protein-protein interactions that are beli

183 , new tissue height was more similar between enamel matrix protein-treated defects and control defect

184 and function of amelogenin, the predominant enamel matrix protein.

185 Ameloblasts synthesize and secrete the enamel matrix proteins (amelogenin, ameloblastin, and en

186 Intrabony defects were treated either with enamel matrix proteins (EMP group) or with enamel matrix

187 Enamel matrix proteins (EMP) have been shown to enhance

188 aluate the effectiveness of a combination of enamel matrix proteins (EMP), bovine porous bone mineral

189 -X-Y motif, the molecular mechanism by which enamel matrix proteins (EMPs) assemble into the organic

190 ntal defects can be achieved with the use of enamel matrix proteins (EMPs) or by grafting with bovine

191 Supramolecular assemblies of enamel matrix proteins (EMPs) play a key role as the str

192 Enamel matrix proteins (EMPs) play a role in enamel form

193 ate, gene expression profiles of major tooth enamel matrix proteins (EMPs), amelogenin (AMELX), ename

194 have identified evidence that the genes for enamel matrix proteins (EMPs), milk caseins, and salivar

195 The enamel matrix proteins amelogenin, ameloblastin, and ena

196 ve analysis may suggest a positive effect of enamel matrix proteins and a negative effect of DG used

197 ns constitute the major portion of secretory enamel matrix proteins and are known to be highly altern

198 various sizes treated with a combination of enamel matrix proteins and autogenous bone graft.

199 tive (EMD) contains a variety of hydrophobic enamel matrix proteins and is extracted from developing

200 Differentiated ameloblasts synthesizing enamel matrix proteins and odontoblasts expressed the ge

201 ects, one using extracellular matrix such as enamel matrix proteins and the other using growth factor

202 i.e., self-assembly, associations with other enamel matrix proteins and with calcium phosphate biomin

203 Embryonic enamel matrix proteins are hypothesized to be involved i

204 Embryonic enamel matrix proteins are involved in the formation of

205 enamel probably by processing and regulating enamel matrix proteins around mineralization front appar

206 , we found that proteolysis of extracellular enamel matrix proteins by MMP20 is not required for the

207 h enamel matrix proteins (EMP group) or with enamel matrix proteins combined with bovine porous bone

208 Matrix metalloproteinase 20 cleaves enamel matrix proteins during the secretory stage, and K

209 al day 5 lower incisors showed downregulated enamel matrix proteins Enam, Amelx, and Ambn.

210 To date, three distinct classes of enamel matrix proteins have been cloned.

211 t data that support cooperative functions of enamel matrix proteins in mediating the structural hiera

212 Several studies have examined the role of enamel matrix proteins in root formation and periodontal

213 arding the potential role of the assembly of enamel matrix proteins in the regulation of crystal grow

214 activity and promotes the phosphorylation of enamel matrix proteins in vitro and in cells.

215 Studies suggest that enamel matrix proteins induce differentiation and minera

216 work is needed to further incorporate other enamel matrix proteins into the system, this study bring

217 Although delayed removal of the enamel matrix proteins may play a role in the hypominera

218 d this technique to determine the effects of enamel matrix proteins on the gene activities of periodo

219 fect of DG used alone or in combination with enamel matrix proteins on the regeneration of Class III

220 nt of various sized periodontal defects with enamel matrix proteins stimulated substantial periodonta

221 to investigate the adsorption properties of enamel matrix proteins to bone grafts after surface coat

222 into immature enamel and removal of cleaved enamel matrix proteins via endocytosis.

223 Although the expression of multiple enamel matrix proteins was down-regulated in the mutant

224 the surface of bone grafting materials when enamel matrix proteins were delivered in either a liquid

225 neutral ethylene diamine tetracetic acid and enamel matrix proteins were used to treat the defects.

226 Amelogenins are a group of extracellular enamel matrix proteins which are believed to be involved

227 by ameloblast differentiation, production of enamel matrix proteins, and crystal growth.

228 Amelogenin and ameloblastin, the major enamel matrix proteins, are important for enamel mineral

229 eviously reported that genes for three major enamel matrix proteins, five proteins necessary for dent

230 ghly conserved AH motif is absent from other enamel matrix proteins, including amelogenin, enamelin,

231 est that in addition to its role of cleaving enamel matrix proteins, MMP20 also cleaves junctional co

232 ta (AI) can be caused by the deficiencies of enamel matrix proteins, molecules responsible for the tr

233 rmal cells that express transcripts encoding enamel matrix proteins, suggest hormonal control of epit

234 rabony defects of various sizes treated with enamel matrix proteins.

235 Amelogenins bind to GlcNAc of the dentine-enamel matrix proteins.

236 dues in the Ser-x-Glu/pSer motifs in several enamel matrix proteins.

237 matrix components, and proteases processing enamel matrix proteins.

238 enamel, as well as the expression pattern of enamel matrix proteins.

239 ole for cathepsin K in degrading re-absorbed enamel matrix proteins.

240 One hypothesis is that enamel matrix proteins/peptides secreted by ameloblasts

241 miR-exon4, with no changes in expression of enamel matrix-related genes.

242 re-secretory ameloblasts to the beginning of enamel matrix secretion.

243 Enamel matrix serine proteinase 1 (EMSP1) is a proteolyt

244 ine proteases, has been variously designated enamel matrix serine proteinase 1 (EMSP1), prostase, KLK

245 We designate this protein enamel matrix serine proteinase 1 or EMSP1.

246 igen (PSA) and 78% identity with the porcine enamel matrix serine proteinase 1, an enzyme involved in

247 s intracellularly and is not secreted to the enamel matrix space to regulate mineralization, and is f

248 he removal of proteins from the mineralizing enamel matrix to allow for crystallite growth until full

249 Calcification of the enamel matrix via hydroxyapatite (HAP) maturation requir

250 omineralized, the protein composition of the enamel matrix was unaltered.

251 ion of proteins secreted into the developing enamel matrix, we have constructed a porcine enamel orga

252 the most superficial layer of the developing enamel matrix, while other enamelin cleavage products ar