ライフサイエンスコーパス: enantiomeric excess

1 ields (conversion, diastereomeric ratio, and enantiomeric excess).

2 alkyl substituents in the 2 position (71-97% enantiomeric excess).

3 lds and high enantioselectivities (up to 92% enantiomeric excess).

4 synthesized in enantioenriched forms (86-90% enantiomeric excess).

5 for selective catalysis with 93% and 79% ee (enantiomeric excess).

6 e reacted with high optical purities (89-98% enantiomeric excess).

7 tuted dehydropiperidinones in high yield and enantiomeric excess.

8 Yields range from 57 to 99% with 78-95% enantiomeric excess.

9 orinated compounds in good yield and in high enantiomeric excess.

10 lution process, which causes a change of the enantiomeric excess.

11 ction of alpha-arylquinolines with up to 90% enantiomeric excess.

12 y been impeded by insufficient yield and low enantiomeric excess.

13 ns to bicycloalkenes in high yield with high enantiomeric excess.

14 deliver target structures in high yield and enantiomeric excess.

15 thesis of QUINAP and its derivatives in high enantiomeric excess.

16 nantioenriched chiral center without loss of enantiomeric excess.

17 terocyclic products in exceptional yield and enantiomeric excess.

18 iastereoselectivity and in high or very high enantiomeric excess.

19 ned in high yield, diastereomeric ratio, and enantiomeric excess.

20 enantiopure configuration, dimerize without enantiomeric excess.

21 r of +/-0.08 mM in concentration and 3.6% in enantiomeric excess.

22 undergo oxidation with complete retention of enantiomeric excess.

23 fording secondary alcohols in high yield and enantiomeric excess.

24 tically useful intermediate with exceptional enantiomeric excess.

25 ted beta-lactones in moderate yield and high enantiomeric excess.

26 ion that affords polycyclic products in high enantiomeric excess.

27 with EtOH to give amide ester (S)-6b in 84% enantiomeric excess.

28 ful chiral building blocks in high yield and enantiomeric excess.

29 tative diastereoselection and high levels of enantiomeric excess.

30 libration is accompanied by complete loss of enantiomeric excess.

31 lated by catalyst design, with no erosion of enantiomeric excess.

32 2-methyl-3-phenylpropanoic acid 14 in >/=95% enantiomeric excess.

33 y on the resolution rate, product yield, and enantiomeric excess.

34 to 93% and enantioselectivities of up to 88% enantiomeric excess.

35 gave the acid in 97% chemical yield and 91% enantiomeric excess.

36 CH-insertion product in 62-69% yield in high enantiomeric excess.

37 ubstrates in high yields and with up to 99 % enantiomeric excess.

38 c cyclopentenones were obtained in up to 75% enantiomeric excess.

39 mations led to the target compound with high enantiomeric excess.

40 yramide 6c yielded the desired (+)-4 in high enantiomeric excess.

41 give the cyclopropyl lactones 17a-d in high enantiomeric excess.

42 and that yields a single regioisomer in high enantiomeric excess.

43 ently cyclized in high yields with up to 99% enantiomeric excess.

44 of substituted d-tryptophan analogs in high enantiomeric excess.

45 ions, nonanionic conditions, and with a high enantiomeric excess.

46 d reactivity and generate products with high enantiomeric excess.

47 th up to >98% conversion and with up to >98% enantiomeric excess.

48 ith aniline afforded the urea product in 51% enantiomeric excess.

49 hesis of tertiary phosphine oxides with high enantiomeric excess.

50 robenzofurans in consistently high yield and enantiomeric excess.

51 in up to 98 % yield and greater than 99.5 % enantiomeric excess.

52 nd provides the title compounds in excellent enantiomeric excess.

53 oth natural products were obtained in >/=99% enantiomeric excess.

54 btained in high chemical yield and with high enantiomeric excess.

55 ohols, yielding up to 96% conversion and 99% enantiomeric excess.

56 ical yield and 100% diastereoselectivity and enantiomeric excess.

57 bound isomer, appear to be critical for high enantiomeric excesses.

58 s, high diastereomeric ratios, and excellent enantiomeric excesses.

59 n of both aldehydes and ketones provided low enantiomeric excesses.

60 product in good to excellent yields and high enantiomeric excesses.

61 ydrofurans are formed with good to excellent enantiomeric excesses.

62 ns of carbenes into C-H bonds with up to 98% enantiomeric excess, 35,000 turnovers, and 2550 hours(-1

63 h, producing a good yield (71%) and a higher enantiomeric excess (64%).

64 ced in good overall yields (20-54%) and high enantiomeric excess (73-97% ee).

65 to give general access to allenes with high enantiomeric excess (84-95%) for both malonate and amine

66 es, (R)- and (S)-12, in good yields and good enantiomeric excesses (84-94%).

67 ltigram synthesis of the carbocycles in high enantiomeric excess (92% ee).

68 rganic catalyst to assemble products of high enantiomeric excess (a single optical isomer), are also

69 itions (-64% enantiomeric excess versus +89% enantiomeric excess); a transformation from one prevalen

70 e indicator chemistry, cellular imaging, and enantiomeric excess analysis, while also being involved

71 n of l-norleucine achieved 0.36 mM with >99% enantiomeric excess and 82% Faradaic efficiency.

72 ion of a cyclic enone in excellent yield and enantiomeric excess and a potentially biomimetic oxidati

73 Improved enantiomeric excess and catalase activity as compared to

74 determination of the absolute configuration, enantiomeric excess and concentration of the target comp

75 faces of the enolate of an azlactone in high enantiomeric excess and diastereomeric excess.

76 is often challenging for mixtures with high enantiomeric excess and for complex molecules with stron

77 s a diverse range of propargylamines in high enantiomeric excess and good yield both in water and in

78 ives access to both enantiomers in excellent enantiomeric excess and good yield.

79 o[3,4:1,2][60]fullerenes with high levels of enantiomeric excess and moderate to good conversions.

80 alcohols are cleaved from the resin in high enantiomeric excess and moderate to good overall yield.

81 ethod that accomplishes determination of the enantiomeric excess and overall amount of a large variet

82 Soai autocatalytic reaction; accounting for enantiomeric excess and rate observations, that is both

83 ha-disubstituted aldehyde hydrazones in high enantiomeric excess and yield.

84 rmation of the 3R alcohol configuration (99% enantiomeric excess) and contrasted with racemic 1-octen

85 94%) with high enantioselectivity (up to 99% enantiomeric excess) and excellent chemoselectivity.

86 high enantioselectivity (typically 90 to 99% enantiomeric excess), and afford products that are key p

87 ctivity and 97%, please refer to compound 2v enantiomeric excess), and can be performed easily on pre

88 nary carbon stereocenters are formed in high enantiomeric excess, and the conditions tolerate a range

89 High yields and enantiomeric excesses are observed for various isochroma

90 ly (microgram concentration) and accurately (enantiomeric excess as low as 0.30% and enantiomeric imp

91 ly (milligram concentration) and accurately (enantiomeric excess as low as 0.6%) determined by use of

92 s with only about 1.5mg/mL concentration and enantiomeric excess as low as 0.80%, in water or in a mi

93 pounds with only microgram concentration and enantiomeric excess as low as 1.5%, in water or in a mix

94 two stereogenic centers are set by DERA with enantiomeric excess at >99.9% and diastereomeric excess

95 kyl groups to benzaldehyde, we have observed enantiomeric excesses between 96% (R) and 75% (S) of 1-p

96 ite furanone derivative was prepared in high enantiomeric excess by an immobilized lipase-catalyzed s

97 itro alcohols in good to excellent yield and enantiomeric excess by borane-dimethyl sulfide in the pr

98 A method for determining enantiomeric excess by mass spectrometry was employed to

99 ketones are prepared in good yield with high enantiomeric excess by rhodium-catalyzed allylic substit

100 Enantiomeric excess calibration curves were made using b

101 Enantiomeric excess calibration curves were made using b

102 molecules and quantitative determination of enantiomeric excess can be achieved in a table-top instr

103 ximately 70% of the variance in the observed enantiomeric excess can be attributed to the steric fiel

104 , thus locking the induced chirality with an enantiomeric excess close to 25%.

105 lized and unfunctionalized olefins with high enantiomeric excesses, demonstrating the potential utili

106 ocess we also explored chirality sensing and enantiomeric excess determinations.

107 Enantiomeric excesses dropped sharply with catalyst load

108 Determining enantiomeric excess (e.e.) in chiral compounds is key to

109 mplification of a spontaneously formed small enantiomeric excess (e.e.).

110 rded a mixtures of trans-(+)-(4S,5R)-4b with enantiomeric excess ee=99% and cis-(-)-(4S,5S)-4a with e

111 ic excess ee=99% and cis-(-)-(4S,5S)-4a with enantiomeric excesses ee=77% and ee=45% respectively.

112 Using the enantiomeric excess (ee %) of the vapor-phase monomer as

113 eported in excellent yields (up to >99%) and enantiomeric excess (ee 99%).

114 ectrocatalytic system was 25.5 mM with 81.2% enantiomeric excess (ee(p)).

115 e 27.6% highest faradaic efficiency and >99% enantiomeric excess (ee(p)).

116 The mechanism for the high enantiomeric excess (ee) (80-90%) observed in the photoc

117 gh levels of asymmetric induction [up to 89% enantiomeric excess (ee) and 92% ee for the two chiral c

118 ocol for the fast determination of identity, enantiomeric excess (ee) and concentration of chiral 1,2

119 ral approach to high-throughput screening of enantiomeric excess (ee) and concentration was developed

120 ons, the enantioselectivity is enhanced; the enantiomeric excess (ee) becomes as high as 46%.

121 olution of homochirality requires an initial enantiomeric excess (EE) between right and left-handed b

122 Enantiomeric excess (ee) determination is crucial in man

123 A method for enantiomeric excess (ee) determination of THFA is presen

124 We report herein an unprecedentedly high enantiomeric excess (ee) for Pd patches deposited onto C

125 Methods for the rapid determination of enantiomeric excess (ee) in asymmetric synthetic methodo

126 The enantiomeric excess (ee) in the endo-cyclobutanols is me

127 ral solvating agents (CSAs) to determine the enantiomeric excess (ee) of 18 MA samples over a wide ee

128 oncurrent determination of concentration and enantiomeric excess (ee) of a chiral analyte, which has

129 conditions as a means to obtain the highest enantiomeric excess (ee) of a desired transformation.

130 s (eIDAs) were used for the determination of enantiomeric excess (ee) of alpha-amino acids as an alte

131 diastereomeric excess (de) limits the final enantiomeric excess (ee) of any phosphorus products deri

132 Solutions with as little as 1% enantiomeric excess (ee) of D- or L-phenylalanine are am

133 sented chiral assay is able to determine the enantiomeric excess (ee) of D-cysteine in the whole rang

134 Finally, the prediction of enantiomeric excess (ee) of test samples with various al

135 A large L-enantiomeric excess (ee) of the alpha-methyl amino acid

136 s were observed leading to variations in the enantiomeric excess (ee) of the chemisorbed layers with

137 influence the course of a reaction, with the enantiomeric excess (ee) of the product linearly related

138 been exploited for precise quantification of enantiomeric excess (ee) ratio (R/S) up to 99:1 in the p

139 Broadly useful chiroptical enantiomeric excess (ee) sensing remains challenging and

140 an be furnished with yields up to 92% and an enantiomeric excess (ee) up to 99%.

141 ns with total turnovers (TTN) up to 4070 and enantiomeric excess (ee) up to 99%.

142 eir chemical characterization and associated enantiomeric excess (ee) values are commonly reported.

143 e for the high-throughput screening (HTS) of enantiomeric excess (ee) values.

144 idine-3-carboxylates from nitriles in 68-90% enantiomeric excess (ee) via allylboration, followed by

145 Enantiomeric excess (ee) was originally defined as a ter

146 th dimethylmalonate can be catalyzed in high enantiomeric excess (ee) with a beta-turn-based ligand.

147 High enantioselectivity (80-92% enantiomeric excess (ee)) has been obtained for the epox

148 from 88 to 96% and in enantioselectivities (enantiomeric excess (ee)) ranging from 85 to 97%, with d

149 very high levels of enantioselectivity (>95% enantiomeric excess (ee)).

150 from irradiations of (R)-2 retain up to 31% enantiomeric excess (ee), but the ees of the same photop

151 mixtures to be analyzed for as little as 1% enantiomeric excess (ee), by simply recording the ratios

152 ical analysis of reaction parameters such as enantiomeric excess (ee), diastereomeric excess (de), an

153 enantiopurity and the precise measurement of enantiomeric excess (ee).

154 ccurately modeled the calibration curves for enantiomeric excess (ee).

155 This is one of the highest enantiomeric excesses (ee %) and yields reported so far

156 ed syn-products (de = 60-99%), with moderate enantiomeric excesses (ee = 43-56%) but did not produce

157 afforded cyclization products at comparable enantiomeric excesses (ee's) and 4-7 times higher cataly

158 istribution, and scope of these amino acids' enantiomeric excesses (ee) have been frustrated by the r

159 Therefore, the detection of l- or d-enantiomeric excesses (ee) of chiral amino acids and sug

160 The most pristine CRs also revealed natal enantiomeric excesses (ee) of up to 60%, much larger tha

161 d the SERS intensity was proportional to the enantiomeric excesses (ee) values.

162 sm (FT-VCD) to follow changes in the percent enantiomeric excess (% EE) of chiral molecules in time u

163 ot-mean-square error (rmse) in the predicted enantiomeric excess (%ee) of about 8.4 +/- 1.8 compared

164 Whereas the er (or enantiomeric excess, ee) of chiral molecules is readily

165 t- (left-)handed twisted nanoribbons with an enantiomeric excess exceeding 30%, which is approximatel

166 nantioenriched alpha-branched amines (>/=96% enantiomeric excess) featuring two minimally differentia

167 lucidate the correlation between defects and enantiomeric excess, five characterization techniques (F

168 methylformamide) and observed an increase in enantiomeric excess for 1-phenylethanol of 35% with the

169 Accurate determinations of enantiomeric excess for amino acids and the chiral drug

170 eous determination of percent conversion and enantiomeric excess for each substrate.

171 ure of H(2) caused a significant increase in enantiomeric excess for low catalyst loading reactions.

172 Catalyst 5a, which gave high enantiomeric excesses for certain substrates without the

173 terms of product substrate scope and product enantiomeric excess) for the generation of enantioenrich

174 e conveniently prepared in one step and high enantiomeric excess from propionyl chloride, using a cat

175 nantioselectively, with yields of 21-74% and enantiomeric excesses from 6 to 64% at 50 degrees C.

176 Primary allylic amines with enantiomeric excesses from 97 to >99% were prepared by a

177 c alpha-olefins into chiral products with an enantiomeric excess greater then 90 per cent.

178 proceeds in nearly quantitative yields with enantiomeric excesses greater than 99.7%.

179 ,7'-dihydroxy-8,8'-biquinolyl (1), in modest enantiomeric excess (> or =37%, > or =77% ee).

180 enyl phosphines (1a-h) were prepared in high enantiomeric excess (>95% ee in most cases) by way of an

181 roxyacids in good yield (65-70%) and in high enantiomeric excess (>99%).

182 chiral inorganic compounds with significant enantiomeric excess has been demonstrated.

183 architecturally complex heterocycles in high enantiomeric excess has been developed.

184 High enantioselectivity (89-93% enantiomeric excess) has been attained for this challeng

185 Good results in terms of yield and enantiomeric excess have been obtained in ionic liquid g

186 diastereomers of the Henry adduct with high enantiomeric excess, homochiral at the oxygen-bearing ca

187 sly from reaction mixtures, with an enhanced enantiomeric excess if initially enantioenriched, which

188 d the formation process could also result in enantiomeric excesses if the incident radiation is circu

189 tract about 3.5 mg of glutamic acid with 95% enantiomeric excess in 24 h.

190 demonstrate in principle how high levels of enantiomeric excess in a mixture of enantiomers can be q

191 measured value for Murchison is the largest enantiomeric excess in any meteorite reported to date, a

192 metric amplification-the development of high enantiomeric excess in biomolecules from a presumably ra

193 tant beta-nitroamines are obtained in 70-94% enantiomeric excess in good yield and can be readily red

194 ed on ion/molecule reactions for determining enantiomeric excess in mixtures of amino acids is illust

195 -methyl-1-hexanols in 88-92% yield in 90-92% enantiomeric excess in one step.

196 of racemic propylene oxide, thus leaving an enantiomeric excess in the solution phase.

197 d summarise recent thoughts on the origin of enantiomeric excess in the universe.

198 ropyl C-H bonds in high yields and with high enantiomeric excesses in the presence of a rhodium catal

199 s lead to stereodifferentiation and, thus to enantiomeric excesses in the products.

200 e presented, which consistently provide high enantiomeric excesses in the range 91-98%.

201 The enantiomeric excess increased to 8 +/- 4%, 27 +/- 1%, an

202 Enantiomeric excess is strikingly insensitive to tempera

203 Improvement of enantiomeric excesses is attained by the use of catalyti

204 Thus, erosion of the enantiomeric excesses is observed for one of the two pro

205 zed asymmetric allylic alkylation yields 92% enantiomeric excess, matching prior solution-phase resul

206 -dependent enantioselectivities, with higher enantiomeric excesses obtained at lower pressures.

207 s largest for erythrose, which may reach a D-enantiomeric excess of >80% with L-Val-L-Val catalyst.

208 olysis in giving unsaturated alcohol with an enantiomeric excess of >95%.

209 On the other hand, the enantiomeric excess of (+)-pinoresinol formed was depend

210 e liquid chromatography purification, a high enantiomeric excess of (18)F-FDOPA ( approximately 97%)

211 n 64% yield as a single diastereomer with an enantiomeric excess of 89%.

212 -1-substituted 1-propanols 10a-n with a mean enantiomeric excess of 92%.

213 overall yield of 55% (three steps) and high enantiomeric excess of 95%.

214 ms are achieved in yields as high as 99% and enantiomeric excess of 97% under aqueous conditions at r

215 to create a bicyclic enal in one step and an enantiomeric excess of 98%.

216 ane in satisfactory yield and with excellent enantiomeric excess of 99%.

217 etermination of enantiomeric purity up to an enantiomeric excess of 99.8%.

218 the enantiomer in the mixture and scale with enantiomeric excess of a component.

219 s a high-throughput method for measuring the enantiomeric excess of allylic acetates.

220 mination of the identity, concentration, and enantiomeric excess of chiral vicinal diols, specificall

221 es and could also significantly increase the enantiomeric excess of direct asymmetric synthesis and c

222 kinetic method, allows rapid quantitation of enantiomeric excess of drug mixtures.

223 organic nanostructures obtained from growing enantiomeric excess of intrinsically chiral NCs or arran

224 Changes in the enantiomeric excess of mixed monolayers of chiral dipept

225 ve linear model was applied to determine the enantiomeric excess of samples of two alcohols without a

226 easurements of both the total amount and the enantiomeric excess of several amino alcohols at micromo

227 of Leu, Pro, and Phe can be deduced from the enantiomeric excess of sublimates, the behavior of the k

228 inkers, impacts on the reaction rate and the enantiomeric excess of the aldol products.

229 The enantiomeric excess of the chiral fatty acids has been m

230 g the QR(fixed) method for determinations of enantiomeric excess of the drug DOPA in the presence of

231 amplitudes of the specific Cotton effect and enantiomeric excess of the parent amine gives potentiali

232 Consequently, the enantiomeric excess of the partial sublimate is dependen

233 The enantiomeric excess of the product was determined by 19F

234 tic amounts of host are able to increase the enantiomeric excess of the products formed.

235 zed with no significant loss in the yield or enantiomeric excess of the products.

236 vided strong evidence that the modulation of enantiomeric excess of the reaction product indeed stems

237 The enantiomeric excess of three different asymmetric cataly

238 opure complex, alcohols are produced with an enantiomeric excess of up to 85% (S) at TOF up to 2000 h

239 lent enantioselectivity is achieved, with an enantiomeric excess of up to 99%.

240 nd seven-membered N-heterocyclic amines with enantiomeric excesses of >90% in many cases and up to 99

241 3-substituted morpholines in good yield and enantiomeric excesses of >95%.

242 ne ethers that are axially chiral, very high enantiomeric excesses of cyclopentenone products are obs

243 cal distribution of d- and l-crystals, large enantiomeric excesses of either d- and l-crystals can be

244 accurately determine the concentrations and enantiomeric excesses of five unknown samples with an av

245 er of substituents in the 4-position, giving enantiomeric excesses of greater than 82%.

246 s and sugar acids (aldonic acids) with large enantiomeric excesses of the same chirality as terrestri

247 Enantiomeric excesses of up to 72% (S) and 70% (R) were

248 n of ketones, giving reduction products with enantiomeric excesses of up to 99%.

249 S)-alpha-phenyltryptamine derivative with an enantiomeric excess over 99%.

250 PV reaction does not affect product yield or enantiomeric excess over time.

251 Enantiomeric excesses range from 60-99% for a collection

252 ization of 1,3-meso-diols is successful with enantiomeric excesses ranging from 78 to 85%.

253 In one case, the enantiomeric excess reaches 95:5 er, and the reactions c

254 of 1-Endo with 3 was found to give 2 in high enantiomeric excess, regardless of pressure and at a rat

255 cellent enantiomeric purities (>98% and >96% enantiomeric excess, respectively).

256 ite that provided the amination product with enantiomeric excess similar to the original, more struct

257 decreases the reaction rate, while affording enantiomeric excesses similar to the 1:1 BoxH:Ln case.

258 oin is produced by the variants with greater enantiomeric excess than by wild-type YPDC.

259 complex because it is enantiomer ratio, not enantiomeric excess, that directly reflects relative rat

260 The determination of enantiomeric excess, that is, the relative amount of any

261 into valuable chiral benzylic amines in high enantiomeric excess, thereby producing motifs found in p

262 A protocol for evaluating enantiomeric excess through formation of the gamma-lacto

263 timation of selectivity and determination of enantiomeric excess, through to control of regio- and st

264 and produced R-epoxypropane with comparable enantiomeric excess to AMO purified from the original or

265 e asymmetric reactions also impart increased enantiomeric excess to the final product in comparison w

266 ng asymmetric Doyle-Kirmse reactions with an enantiomeric excess up to 71 %.

267 This method provides high conversion and enantiomeric excess up to 84% of the desired chiral seco

268 Enantiomeric excesses up to 83% were obtained in the cas

269 entenols 3a-l in good to excellent yields in enantiomeric excesses up to 99%.

270 izontal lineC bond were hydrogenated in high enantiomeric excess (up to >99% ee).

271 ould be successfully obtained with excellent enantiomeric excess (up to >99% ee).

272 products in very good yield (up to 99%) and enantiomeric excess (up to 93%).

273 iral cyclopentane derivatives with excellent enantiomeric excess (up to 94% ee).

274 ective cyclobutane products with significant enantiomeric excess (up to 95% ee).

275 products in very good yield (up to 90%) and enantiomeric excess (up to 95%).

276 drogenated in high regioselectivity and high enantiomeric excess (up to 98% ee).

277 e challenges to yield gamma-lactones in high enantiomeric excess (up to 99%) using hydrogen peroxide

278 ing scaffold with high yield (up to 99%) and enantiomeric excess (up to 99%).

279 ng para substituents resulted in the highest enantiomeric excess, up to 88%.

280 MDee for an enzymatic method for determining enantiomeric excess, uses the lipase from Pseudomonas ce

281 ding 1,2-diols were produced in good-to-high enantiomeric excess using 0.45 equiv of H(2)O.

282 is used to develop a method for determining enantiomeric excess using only mass spectrometry.

283 n-time-dependent data for concentrations and enantiomeric excess values for substrates and [1,3] shif

284 -polyheterocycles of complex topologies with enantiomeric excess values up to 90%.

285 ogenation of benchmark substrates furnishing enantiomeric excess values up to 96%.

286 good chemical and radiochemical purities and enantiomeric excess values.

287 gh-temperature/low-pressure conditions (-64% enantiomeric excess versus +89% enantiomeric excess); a

288 with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.

289 The enantiomeric excess was found to be proportional to the

290 For a terminal 1,6-enyne, the incremental enantiomeric excess was found to increase from 4 to 26%

291 ith esters bearing alpha-stereocenters, high enantiomeric excess was maintained during ketone formati

292 yed a critical role in whether an erosion in enantiomeric excess was observed.

293 Diastereomeric ratios >20:1 and up to 99% enantiomeric excesses were observed.

294 r the syn or anti adduct selectively in high enantiomeric excess when an appropriate chiral ligand wa

295 exo/endo ratios and excellent diastereo- and enantiomeric excesses when in situ formed [Ir(I)/Tol-SDP

296 es (up to 99 per cent yield with 99 per cent enantiomeric excess), which otherwise are difficult to a

297 produce the vinyl iodide segment 17 in high enantiomeric excess, which was used in a key B-alkyl Suz

298 ssfully cross-coupled in excellent yield and enantiomeric excess with prior conversion of the pinacol

299 I) complexes generated products in 90 to 99% enantiomeric excess with the use of chiral binaphthol-de

300 ocess led to the expected product (up to 87% enantiomeric excess), with its reuse being possible at l