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1 ble gelation, nanofabrication, and molecular encapsulation.
2 s based upon selective solid-phase molecular encapsulation.
3 -methacrylic acid) as shell material for the encapsulation.
4 However, this limitation may be mitigated by encapsulation.
5  can emerge as the driving force for alcohol encapsulation.
6  nanodroplets stabilized by polymeric ligand encapsulation.
7 ncreased thermal stability of all oils after encapsulation.
8 fe carrier and therefore utilized for MTI-31 encapsulation.
9 ase in activity and selectivity upon polymer encapsulation.
10 ng approach to be suitable for nano-liposome encapsulation.
11  by co-assembly processes rather than simple encapsulation.
12 ding motifs on IL-12 allow for its effective encapsulation.
13 ctively by immune response-induced electrode encapsulation.
14 fic intermolecular interactions are used for encapsulation.
15 e hydrophobic moieties offer stable and high encapsulation.
16 d a slow release for both the vitamins after encapsulation.
17 aracterization indicated a satisfactory TCIN encapsulation (33.20 +/- 0.85%), spherical shape, pH-res
18                              In air, without encapsulation, a tandem retained 95% of its initial effi
19 e assembly kinetics, thus enabling efficient encapsulation, a tunable drug release profile, improved
20 clude conjugation of CpGODN with proteins or encapsulation/adsorption of CpGODN into/onto liposomes,
21                                    Bacterial encapsulation affected the volatile and amino acid profi
22 nctionalized nanotubes, which are wrapped by encapsulation agent (phospholipid-polyethylene glycol),
23          Its customizable filtering and data encapsulation allow it to be adapted to a wide range of
24                                 Microfluidic encapsulation and barcoding was used to perform single n
25         We have developed a platform for the encapsulation and controlled, tunable release of cell-de
26 ropylene sulfide) (PPS) and use them for Rg3 encapsulation and delivery.
27 oncentration, CaCl(2) level, hardening time, encapsulation and emulsion fabrication methods was studi
28 llowed monitoring the molecular basis of the encapsulation and guest competition processes at a very
29 he inherent lipophilicity of VSDs by dynamic encapsulation and high-affinity ligands to target the co
30 predictive tool for understanding host-guest encapsulation and interactions in numerous supramolecula
31 e picture of the subtle events directing the encapsulation and is thus a predictive tool for understa
32 ons persist regarding the mechanisms of cell encapsulation and mineral polymorphism.
33 l genetic engineering approaches to external encapsulation and modification, and summarize the most r
34                                              Encapsulation and molecular targeting of therapeutic ant
35 of the cage in the solvent, the (rare) guest encapsulation and release events, and the relative proba
36                While the innovations in drug encapsulation and release mechanisms, biocompatibility,
37 ilizing PCMs as a versatile platform for the encapsulation and release of various types of therapeuti
38 precisely controlled propensity in molecular encapsulation and release process.
39                           We show that shell encapsulation and the internal microenvironment of the n
40  too hydrophilic for cell uptake and payload encapsulation, and may cause unintended biological respo
41       Post-storage, hLMSC were released from encapsulation, and viability-assessed cells were plated.
42 mbinatorial nano-engineering and biomaterial encapsulation approach, could therefore offer key advant
43 trodes and varying enzyme producing strains, encapsulation approaches (layer-by-layer (LbL) or one-st
44 ying variety of polymers, drug molecules and encapsulation approaches with primary focus on oral deli
45 ns examined had a high efficiency of prodrug encapsulation (as high as 114 mol% taxane per mole phosp
46 rticles are then identified by droplet-based encapsulation, barcoded 16S rRNA amplification and deep
47 moist environments due to a lack of suitable encapsulation barriers.
48 are vulnerable to the digestive process, and encapsulation becomes an alternative for their preservat
49  the explicit aim of demonstrating liposomal encapsulation, bioavailability in cultured neuroblastoma
50 rance, offer compatible environment for drug encapsulation, biocompatibility, high drug loading and t
51  a supernegatively charged (-30)GFP enhances encapsulation by cationic lipids and delivery into mamma
52                                              Encapsulation by freeze-drying using maltodextrin, gum A
53               The microbiota directs its own encapsulation by inducing Muc2 production from proximal
54                                              Encapsulation by these compartments was observed even wh
55 microcapsule and the one-step method of cell encapsulation can be a versatile 3D NIM system for spont
56     This article demonstrates that molecular encapsulation can be used as a powerful tool to tune int
57 ) deficiencies are reported worldwide and co-encapsulation can provide a combined solution to this pr
58 d tumour targeting and nanoparticle-mediated encapsulation can reduce the toxicity of antitumour drug
59 , size-dependent permeability, and selective encapsulation capacity without sacrificing their dynamic
60 interactions that occur upon fullerene guest encapsulation characterized by a range of techniques inc
61 r surfaces, as a soft, elastic substrate and encapsulation coating for wireless electronic components
62 esults in roughly 2.5 times more therapeutic encapsulation compared to loading particles in their con
63                                           Co-encapsulation demonstrates a synergistic increase in IL-
64                   The results indicated that encapsulation depended on organic phase concentration, w
65                      The supramolecular self-encapsulation design provides an effective strategy to c
66                                          The encapsulation dramatically enhances the stability of pro
67 eat promise to the biological separation and encapsulation due to their excellent biocompatibility.
68 s is suggestive of integrins transducing the encapsulation effect into intracellular signalling casca
69  size effect, supercage stabilization in the encapsulation effect, site adsorption in the recognition
70 PRAS-NLCs proposed yield high extraction and encapsulation efficiencies (71 +/- 4%) in combination wi
71 ormulations with only WP or LE showed higher encapsulation efficiencies (EE) (95-98%) and antibacteri
72 h as spray-drying and freeze-drying, finding encapsulation efficiencies (EE) up to 98% and spherical
73      The particle sizes, zeta potentials and encapsulation efficiencies for the prepared nanoliposome
74 llar Nanoprobe (TMNP) had exceptionally high encapsulation efficiencies of a hydrophobic drug simvast
75                                              Encapsulation efficiencies of nearly 50% were achieved i
76 h zeta-potential of -25 mV, and high vitamin encapsulation efficiency (94-96%).
77 EDTA remote loading methods had a comparable encapsulation efficiency (EE%) into LTSLs in contrast to
78 ed average particle sizes of 107 and 222 nm, encapsulation efficiency (EE) and loading efficiency (LE
79 an exhibited a higher physical stability and encapsulation efficiency (EE) compared with other sample
80                                          The encapsulation efficiency (EE) was determined as a functi
81                                  The highest encapsulation efficiency (EE) was found in SPC-CHO-0.5%H
82 me phenolic losses by diffusion and increase encapsulation efficiency (EE).
83             nMIC and nFIB displayed good CsA encapsulation efficiency (up to 4.5 and 2 mg/mL, respect
84 ethod, we formulated nanoparticles with high encapsulation efficiency (~ 100%) of exendin-4, high pay
85           Prepared nanofibers showed a 47.4% encapsulation efficiency and 73% yield.
86 s of sHDL were tested to optimize both T1317 encapsulation efficiency and ability of T1317-sHDL to ef
87 phology, particle size, zeta potential, pGFP encapsulation efficiency and biological properties such
88                                 Besides, the encapsulation efficiency and in vitro release rate of my
89 t diameter, viscosity, antioxidant activity, encapsulation efficiency and loading capacity of optimal
90         The encapsulated extract showed high encapsulation efficiency and spherical morphology.
91 y and stability, high thermal stability, and encapsulation efficiency carotenoid (>80%) when compared
92                    In addition, results from encapsulation efficiency demonstrated that excess concen
93  relationship between antigen properties and encapsulation efficiency for downstream immune activatio
94 ide range of organic solutes, achieving >95% encapsulation efficiency for hydrophilic small molecules
95 to 16.85% showed a corresponding rise in the encapsulation efficiency from 74.0% to 85.8% and drug lo
96     Nanoparticle manufacture achieved 37-60% encapsulation efficiency in HSA particles (169 nm, zeta
97  analyses confirmed EO encapsulation with an encapsulation efficiency of 55%, 71%, and 74% for 1, 3,
98 articles were 322.7, 559.2 and 615.6 nm with encapsulation efficiency of 59.09, 48.30, and 55.00% and
99 repared, rHDL/Do nanodrug achieved high drug encapsulation efficiency of 90.47%, and mimicked the con
100 ogy, a mean diameter of 96.4 nm, and with an encapsulation efficiency of 99%.
101 d strong entrapment of mRNA and pDNA with an encapsulation efficiency of above 95%.
102          The SIO microcapsules showed a high encapsulation efficiency of approximately 94.12% in the
103                                 Finally, the encapsulation efficiency of aspartic protease in lipid s
104                                          The encapsulation efficiency of the CD-lipoplex complexes we
105                 The antioxidant activity and encapsulation efficiency of the encapsulated material ob
106                                          The encapsulation efficiency varied from 31.66 to 84.48%.
107                                          Oil encapsulation efficiency was high (>=89%) and oil within
108                                          The encapsulation efficiency was higher for LBL microcapsule
109              Micrometric particles with high encapsulation efficiency were produced and thermal analy
110 namic light scattering, electron microscopy, encapsulation efficiency, and drug loading capacity.
111 inning technique, and their structures, drug encapsulation efficiency, and release characteristics we
112 on (span), morphology, drug/gelatin loading, encapsulation efficiency, and residual DCM and water con
113  in terms of morphology, particle size, drug encapsulation efficiency, in vitro release and cytotoxic
114 sodium alginate and emulsifiers, showed high encapsulation efficiency, low antioxidant activity and s
115 /Vis) spectrophotometry, carotenoid profile, encapsulation efficiency, morphology, and thermal analys
116                                          The encapsulation efficiency, protection of dsRNA from nucle
117 nthocyanin content, antioxidant activity and encapsulation efficiency.
118 ential of -20 mV, and exhibit high docetaxel encapsulation efficiency.
119 rticles with well-controlled shapes and high encapsulation efficiency.
120 cost-effective drug carrier system with high encapsulation efficiency.
121 re not captured, Br, I and Te exhibit strong encapsulation energies while Rb is only weakly encapsula
122                         Here, we showed that encapsulation enhanced the antidepressant effects of MSC
123 alysis within the metallocage shows that its encapsulation favors the reaction.
124      Further, the recent studies of vitamins encapsulation for applications in functional foods and n
125 g dendrimer platform and injectable hydrogel encapsulation for delivery of an adenovirus encoding Fla
126  host processes, we develop an aqueous-based encapsulation formulation with a microbiota-based releas
127  of the supramolecular assembly and catalyst encapsulation further engenders reaction selectivity, wh
128                                     However, encapsulation had a significant effect (p < 0.05) on the
129 moisture content and successful of molecular encapsulation have been evaluated by thermal and spectro
130 ion and separations, chemical adsorption and encapsulation, heterogeneous catalysis, photoredox catal
131                                              Encapsulation improved retention of PP and AOC upon ther
132                        Our results show that encapsulation improves differentiation by significantly
133 e also demonstrate improved outcome of islet encapsulation in a chemically-induced diabetic mouse mod
134          The device is also tested for islet encapsulation in an immunocompetent diabetes rodent mode
135                                 After sample encapsulation in droplets and target enrichment with the
136 dy explores the mechanical basis of germline encapsulation in Drosophila gametogenesis, reporting tha
137                                 In contrast, encapsulation in the Dual PEG capsules prevented sensiti
138 tal clusters and nanoparticles through their encapsulation in the voids of zeolite frameworks as well
139                                              Encapsulation inflates the host, enhancing its ability t
140                                 Nanoparticle encapsulation inside zirconium-based metal-organic frame
141        Here, we demonstrate that biomaterial encapsulation into alginate using a microfluidic device
142 easy-to-use workflow for precise single-cell encapsulation into picoliter-scale double emulsion dropl
143                                   Successful encapsulation into these micelles has been demonstrated
144                                              Encapsulation involves the incorporation of the active m
145                                    Biosample encapsulation is a critical step in a wide range of biom
146    Modifying the reactivity of substrates by encapsulation is a fundamental principle of capsule cata
147 t generation with a single particle and cell encapsulation is a random process and suffers from a low
148 findings of this study suggest that alginate encapsulation is an effective method of hLMSC preservati
149  improving the stability of MNW networks via encapsulation is discussed.
150 of supramolecular polymerization and droplet encapsulation is used to control the position of self-as
151  as 300 degrees C in ambient air without any encapsulation, is demonstrated.
152 drogenated phosphatidylcholine (HPC) for the encapsulation lactoferrin (LF) was studied; lipid membra
153 lly decomposition) resulted, indicating that encapsulation led to host-selective reaction trajectorie
154            We demonstrate that EC and NSC co-encapsulation maintained NSC quiescence, enhanced NSC vi
155 yer-by-layer approach, we generated nanothin encapsulation materials containing tannic acid (TA), a p
156                   By testing different oils, encapsulation matrices and oxidation conditions, results
157 itions in different plants and this range of encapsulation matrices provides a great deal of commerci
158                                         Cell encapsulation may enhance the survival rate of grafted c
159 ance the stability of chlorophyll, a polymer encapsulation method was proposed.
160                                         This encapsulation methodology simplifies the screening of re
161 ve sustained drug release using conventional encapsulation methods.
162                                     However, encapsulation of [Au(25)(Cys)(18)] and CV into the polym
163 bactericidal mechanism shows that additional encapsulation of [Au(25)(Cys)(18)] into the CV treated p
164  report here a supramolecular strategy where encapsulation of a hydrogenation catalyst enables select
165                                     However, encapsulation of a strong cytotoxic drug completely shut
166 s the significant role of nanotechnology for encapsulation of AIs for pesticides.
167 ar structures known as chromocenters ensures encapsulation of all chromosomes into a single nucleus (
168 e optimized for achieving the most efficient encapsulation of anthocyanin using a three level, three
169 0.3% NBRE-15 was found to be optimum for the encapsulation of anthocyanin with the desirability of 92
170 d WPI-based nanocapsules can be used for the encapsulation of beta-carotene answering the industrial
171 esent structural and functional benefits for encapsulation of bioactive ingredients.
172                                          The encapsulation of bioactive lipophilic compounds by compl
173 mum) which makes it a suitable candidate for encapsulation of biological samples.
174 s, functionalization for magnetic actuation, encapsulation of biomolecules, and surface functionaliza
175                             In addition, the encapsulation of bis-aza[60]fullerene (C(59)N)(2) within
176 C12A7 shows a significant enhancement in the encapsulation of Br, I and Te with all three stable as a
177                                          The encapsulation of broccoli extract, by electrospraying, w
178  sites in the structure of the cage, and (3) encapsulation of catalysts within the cage.
179 650, 1383, 1148, 1083 and 790 cm(-1) depicts encapsulation of catechin in starch nanoparticles withou
180 on sequencing (i-BLESS), which relies on the encapsulation of cells in agarose beads and labeling bre
181 at active cargo loading reduces non-specific encapsulation of cellular proteins, particularly nucleic
182                                   Reversible encapsulation of CH(2) Cl(2) or Xe in a non-porous solid
183 helicate containing a bisporphyrin unit upon encapsulation of chiral aromatic guests between the bisp
184                                              Encapsulation of chiral guest molecules such as [(R/S)-1
185 erived nanobiotics, alone or with additional encapsulation of clofazimine (CFZ), enhance killing of m
186                                              Encapsulation of clove oil was proposed as a mean to dis
187 an expanded scorpionate ligand suited to the encapsulation of cuboidal clusters.
188 dy two approaches have been explored for the encapsulation of DHA in the pH dependant polymer hydroxy
189                                          The encapsulation of drugs into lipid-based nanoparticles wi
190 poly(lactic-co-glycolic acid) (PLGA) allowed encapsulation of DSP into biodegradable nanoparticles (N
191                               With liposomal encapsulation of each drug pair, we enabled uniform drug
192 ctron transfer rates, paving the way for the encapsulation of electroactive catalysts and electrocata
193  strong acids during synthesis, allowing the encapsulation of enzymes into three prototypical robust
194                                          The encapsulation of enzymes within porous materials has sho
195 ollowed by a survey of the literature on the encapsulation of enzymes, growth factors, antibodies, ho
196    This proof-of-concept study describes the encapsulation of fatty acids, in vivo bioavailability, a
197  multistage process that starts from diamond encapsulation of ferropericlase followed by decompressio
198  we demonstrate the synthetically controlled encapsulation of first-row transition metals (M = Mn, Fe
199       In this work, we report the controlled encapsulation of gold nanorods (AuNRs) by a scu-topology
200     This study is one of its kind where nano-encapsulation of GPP into W/O emulsion was done to stabi
201 biomaterial during printing, or intermediary encapsulation of growth factors in delivery vehicles suc
202                                              Encapsulation of homonuclear dimers (Br(2), I(2) and Te(
203                                              Encapsulation of Imatinib into targeted nanoparticles co
204 hen, investigate the use of hydrogels in the encapsulation of insulin secreting cells with a special
205 fulfill their specialized functions, such as encapsulation of invading pathogens, cell-cell fusion in
206 cular), and induction of immune tolerance or encapsulation of islets.
207 nsights into the beta-cyclodextrin (beta-CD) encapsulation of key compounds in coffee (CGA 1, CFA 2,
208 measurements (CREM) confirmed the successful encapsulation of M within {Mo(132)PO(4)} and furthermore
209 -assembly approach, we demonstrate efficient encapsulation of medium to large proteins (HRP, 44 kDa a
210 therapeutic effects and mechanisms mediating encapsulation of MSCs remain unexplored.
211                                   Successive encapsulation of multiple Br, I and Te as single anions
212 ng strategies typically require the complete encapsulation of nanostructures, which makes accessing t
213 rine model of systemic infection resulted in encapsulation of NESp and increased virulence during bac
214                            The impact of the encapsulation of Oenococcus oeni into SiO(2)-alginate hy
215                           In both cases, the encapsulation of OLE led to higher OE contents at the en
216 yringe-injectable and support cytocompatible encapsulation of oligodendrocyte progenitor cells (OPCs)
217 action analysis of [3.F(-)] reveals that the encapsulation of one fluoride, within 3, occurs through
218 gainst some food pathogens revealed that the encapsulation of OR and TCA within micelles crucially im
219                  These data demonstrate that encapsulation of P. gingivalis plays a key role in the a
220 ution of Pd into Ag is always preceded by an encapsulation of Pd islands by Ag, resulting in a signif
221  hybrid membranes can be obtained by in situ encapsulation of photoactive molecules (sulfonated spiro
222 , objective of the present investigation was encapsulation of Pimpinella anisum essential oil in chit
223 a-cyclodextrin of high crystallinity for the encapsulation of PIP at high loading capacity.
224 in NS, by microwave-assisted fusion, for the encapsulation of PIP.
225                                              Encapsulation of plasmid DNA vaccine expressing IBV nucl
226                                              Encapsulation of polar and non-polar bioactive compounds
227 center of sulfonic acid groups in COFs after encapsulation of polymeric solvent analogues 1-methyl-2-
228  proposed as a "green" wall material for the encapsulation of pomegranate peel extract.
229                                              Encapsulation of Porphyromonas gingivalis has been demon
230 the use of the lipid sponge (L(3)) phase for encapsulation of proteins has not yet been well explored
231 n act as versatile platforms for the in situ encapsulation of proteins under ambient conditions.
232                                              Encapsulation of proteins within lipid inverse bicontinu
233                       Here, we show that the encapsulation of rituximab within a crosslinked zwitteri
234       Furthermore, it provides a much-needed encapsulation of scattered functionality, making large a
235                                     Overall, encapsulation of shrimp oil in nanoliposomes was proven
236                 We optimize for preferential encapsulation of single cells with extremely low multipl
237                                              Encapsulation of solid potassium salt of ferrate (K(2)Fe
238 nd ENDOR spectroscopy that substantiated the encapsulation of the first-row transition metal guest.
239 fer multifunctionality in vitro including co-encapsulation of the injury site extracellular matrix mo
240                                   Subsequent encapsulation of the ion exposed MoS(2) flake with high-
241                                              Encapsulation of the lipase-coated lipid/PDMS droplets i
242 at euthanasia and displayed progressive bony encapsulation of the screw.
243 ch implies a mechanism that does not involve encapsulation of the substrate.
244    It also, summarizes the latest reports of encapsulation of therapeutic compounds, and critically d
245                                              Encapsulation of these components within vesicles reorga
246                         Here, we studied the encapsulation of three structurally simple BODIPY deriva
247               This work demonstrates that co-encapsulation of TLR4 and lipidated TLR7/8 agonists with
248    The cavity size allowed for the selective encapsulation of two dye molecules, irrespective of the
249  susceptibility measurements showed that the encapsulation of up to 10 equiv showed little magnetic i
250                    The present work aimed at encapsulation of vitamin B(12) and D(3) by spray drying
251 m (CMTG) were used as wall materials for the encapsulation of vitamin D(3) (VD(3)).
252 atheroma-targeting ability of sHDL allow for encapsulation of water-insoluble drugs and their subsequ
253 rbon nanotube array with nickel-copper alloy encapsulation on a carbon-fiber paper.
254 ing water in order to evaluate the impact of encapsulation on the hydrophilicity of lutein.
255 as to investigate the impact of nanoemulsion encapsulation on transpapillary delivery in vitro.
256 us, whereas the implantation of MSCs without encapsulation or the implantation of eMSCs into the stri
257 To engineer the microenvironment of seeds by encapsulation, preservation, and precise delivery of bio
258 er focuses on the use of a new type of yeast encapsulation procedure, applying the chitosan-calcium a
259 dumbbell-shaped guest in the dynamics of the encapsulation process and in the stability of the final
260                                              Encapsulation process by Saccharomyces cerevisiae is a p
261                                       Halide encapsulation promotes a large conformational rearrangem
262                                     Overall, encapsulation protected PSO against oxidation over time,
263                                     Overall, encapsulation protected RPO during storage, with SEDS-mi
264                      By introducing graphene encapsulation, proteins in solution can be immobilized o
265 d to the confinement effects involving size, encapsulation, recognition, and synergy.
266                           A trend of present encapsulation research indicates an increased interest i
267                                    Liposomal encapsulation resulted in a circulation half-life of ~2
268 t, light, and air stability with and without encapsulation revealed that specific compounds can be ai
269 y of Adv-Flagrp170 by both G4 coating and SH encapsulation significantly enhanced its therapeutic eff
270                                              Encapsulation strategies are widely used for alleviating
271 r research adds to current knowledge in cell-encapsulation strategies by highlighting the importance
272 nsfection efficiency and suitable reversible encapsulation strategies for intracellular delivery with
273                                          The encapsulation strategy of the synthesized red-phosphorus
274    Preparation and characterization of novel encapsulation system based on calcium alginate hydrogels
275 ge proteins in the cytoplasm act as a second encapsulation system preventing starch digestion.
276                                      Such an encapsulation technique ensures cell viability and enabl
277       Spray drying is the most commonly used encapsulation technique to stabilize sensitive bioactive
278  the device structures(10-13), and using new encapsulation techniques(14,15).
279                                              Encapsulation technologies can be used to preserve thera
280 ne answering the industrial demand for novel encapsulation technologies to protect sensitive bioactiv
281                                              Encapsulation technology and the encapsulant agent used
282                                         Drug encapsulation tests confirmed that they are able to load
283             Such measurements require stable encapsulation, that is no escape of the substrate into b
284 riety of applications including nanoparticle encapsulation, the construction of artificial membrane p
285 es may contribute to the development of cell encapsulation therapies for type 1 diabetes and other ho
286 favorable self-assembly thus enables central encapsulation to amplify guest-binding events around the
287 e activation, shell self-assembly, and cargo encapsulation to construct a robust nanoreactor that inc
288  pneumoniae overcomes these defences through encapsulation to effectively colonize this site.
289 n and to evaluate the effect of spray-drying encapsulation using modified starch on PP, antioxidant c
290 ite of this host promotes new modes of guest encapsulation via hydrogen bonding with the pai systems
291 % for both crops, while the efficiency of PP encapsulation was 79% (RCA) and 88% (RCH).
292 NPs) produced via ultra-sonication for rutin encapsulation was explored.The rutin encapsulated SNPs p
293    Taking advantage of the dynamic nature of encapsulation, we developed a system in which reversible
294  and thermogravimetric analyses confirmed EO encapsulation with an encapsulation efficiency of 55%, 7
295 r, the larger size CNB2 does not exhibit any encapsulation with both C(60) and C(70).
296 ructural change of cytochrome c (Cyt c) upon encapsulation within a hierarchical metal-organic framew
297 lization of biomacromolecules, and live cell encapsulation within a hydrogel scaffold.
298 yl-perfluorophenyl polar-pai interactions by encapsulation within a synthetic host, thus increasing t
299 erved at high temperature, which occurs upon encapsulation within a ZIF-62(Zn) MOF glass matrix.
300 ailed structural changes of the enzymes upon encapsulation within the porous material, which are clos

 
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