ライフサイエンスコーパス: endochondral

1 homozygous mutant mice demonstrated delayed endochondral and intramembranous bone formation, whereas

2 Widespread endochondral and intramembranous ectopic bone formation

3 vel intrinsic differences in bone genesis by endochondral and intramembranous mechanisms.

4 in Sox9-expressing cells exhibited a lack of endochondral and intramembranous ossification and a lack

5 s suggest the differential roles of TRPM7 in endochondral and intramembranous ossification.

6 pair, but inefficient fibrinolysis decreases endochondral angiogenesis and ossification, thereby inhi

7 tron, is a layered structure formed by basal endochondral axial skeletal elements (ribs, vertebrae) a

8 ories of a phylogenetically deeper origin of endochondral bone and its absence in chondrichthyans as

9 nd tenocytes, and instead results in ectopic endochondral bone at tendon-bone attachment units.

10 provide evidence for neogenin in regulating endochondral bone development and BMP (bone morphogeneti

11 tilage extracellular matrix is essential for endochondral bone development and joint function.

12 r and osteogenic transformation essential to endochondral bone development and repair.

13 ate that B-Raf and A-Raf are dispensable for endochondral bone development and they indicate that the

14 mation even though the molecular program for endochondral bone development appeared intact.

15 feration and delay chondrocyte maturation in endochondral bone development at least partly through cy

16 nsable for osteoblast differentiation during endochondral bone development in the mouse embryo.

17 However, how these cells originate during endochondral bone development is unknown.

18 ompensate for the lack of C-P4H-II in proper endochondral bone development, but their combined partia

19 expression that was associated with impaired endochondral bone development, defective osteoblast-medi

20 issue growth and perfusion, ossification and endochondral bone development, leading to radiographic c

21 We have also shown that VHL is important for endochondral bone development, since loss of VHL in chon

22 During endochondral bone development, the first osteoblasts dif

23 To investigate the role of Wdr5 during endochondral bone development, transgenic mice overexpre

24 tudy the requirement for GSK activity during endochondral bone development, we inhibited GSK3 in cult

25 asculature is also known to be essential for endochondral bone development, yet the underlying mechan

26 pressed in chondrocytes, play major roles in endochondral bone development.

27 rocyte and osteoblast differentiation during endochondral bone development.

28 uption of the molecular program required for endochondral bone development.

29 Fracture healing recapitulates aspects of endochondral bone development.

30 hh) critically regulates multiple aspects of endochondral bone development.

31 NO, CNP and cGKII signaling in cartilage and endochondral bone development.

32 ar and cellular resolution available for the endochondral bone development.

33 Chondrocyte hypertrophy is essential for endochondral bone development.

34 ent in both A-Raf and B-Raf exhibited normal endochondral bone development.

35 form a grossly intact skeleton with impaired endochondral bone development.

36 xpression is a major function of GSK3 during endochondral bone development.

37 rtially through regulating Gli2/PTHrP during endochondral bone development.

38 cytes and osteoblasts is required for normal endochondral bone development.

39 considered as two separate processes during endochondral bone formation after birth, recent studies

40 ignificantly longer than controls because of endochondral bone formation alterations.

41 DREAM-deficient mice show defects in endochondral bone formation and die shortly after birth.

42 Overexpression of Notch inhibits endochondral bone formation and osteoblastic differentia

43 Loss of JNK signaling results in abnormal endochondral bone formation and subsequent severe scolio

44 ement of neurofibromin and ERK1/2 for normal endochondral bone formation and support the notion that

45 nd dental abnormalities implicating TRPS1 in endochondral bone formation and tooth development.

46 get of PTHrP signaling, negatively regulates endochondral bone formation by associating with and inac

47 Clavicle defects are caused by disrupted endochondral bone formation during embryogenesis.

48 l II) and displayed chondrodysplasia with no endochondral bone formation even though the molecular pr

49 rylation; however, a role for Raf kinases in endochondral bone formation has not been identified.

50 chondrogenesis, consistent with the ectopic endochondral bone formation in these patients.

51 Endochondral bone formation including chondrocyte and os

52 Endochondral bone formation is characterized by the prog

53 Endochondral bone formation is exquisitely sensitive to

54 Using a murine model in which endochondral bone formation is triggered in muscle by bo

55 The current concept regarding endochondral bone formation postulates that most hypertr

56 seous junction, leading to partial rescue of endochondral bone formation shown by proper bone length.

57 t that Dym-deficient mice display defects in endochondral bone formation similar to that of Dyggve-Me

58 and the donor cells directly participated in endochondral bone formation via their differentiation in

59 ilage in the hypertrophic zone, few signs of endochondral bone formation, and large regions of disorg

60 tly inhibits chondrocyte differentiation and endochondral bone formation, and this inhibition depends

61 tics did not influence osteoblastogenesis or endochondral bone formation, but notably enhanced osteoc

62 During endochondral bone formation, chondrocytes undergo differ

63 These results suggest that during endochondral bone formation, Lbh may negatively regulate

64 der characterized by extensive extraskeletal endochondral bone formation, share a recurrent mutation

65 ed CSPGs in signaling paradigms required for endochondral bone formation, the brachymorphic (bm) mous

66 To investigate the in vivo role of P63 upon endochondral bone formation, we have established transge

67 way has emerged as an important regulator of endochondral bone formation.

68 olved in bone remodeling and early stages of endochondral bone formation.

69 pertrophy, extracellular matrix turnover and endochondral bone formation.

70 etic protein (BMP) signaling is required for endochondral bone formation.

71 in intramembranous bone formation as well as endochondral bone formation.

72 EP convertase and neutralizes GEP-stimulated endochondral bone formation.

73 itself been shown to be essential for normal endochondral bone formation.

74 ntiation from mesenchymal progenitors during endochondral bone formation.

75 rtrophy is an essential process required for endochondral bone formation.

76 roliferation/differentiation during prenatal endochondral bone formation.

77 played defects in chondrocyte maturation and endochondral bone formation.

78 n part to disruption of Ihh signaling during endochondral bone formation.

79 ) play important roles at multiple stages of endochondral bone formation.

80 cyte death and osteoclast recruitment during endochondral bone formation.

81 ary for complete osteoblastic maturation and endochondral bone formation.

82 triking defects in cartilage development and endochondral bone formation.

83 s, directly transform into bone cells during endochondral bone formation.

84 phic chondrocytes undergo apoptosis prior to endochondral bone formation.

85 owth factor A (Vegfa) has important roles in endochondral bone formation.

86 the age-matched control, with little sign of endochondral bone formation.

87 al defects, reduced body size, and defective endochondral bone growth due to impaired BMP-mediated ch

88 a key driving mechanism responsible for poor endochondral bone growth in achondroplasia disorders cau

89 iation to proceed and significantly improved endochondral bone growth in TDII.

90 of growth plate chondrocytes is required for endochondral bone growth, but the mechanisms and pathway

91 ed inhibition of chondrocyte hypertrophy and endochondral bone growth.

92 metaphyseal side of the growth plate during endochondral bone growth.

93 fusion of ossification centers and limit the endochondral bone growth.

94 anomalies by promoting as well as inhibiting endochondral bone growth.

95 most tissues, it is a negative regulator of endochondral bone growth.

96 ccumulation in the growth plate and improved endochondral bone growth.

97 of developmental disorders that feature poor endochondral bone growth.

98 K) kinase to demonstrate a similar defect in endochondral bone growth.

99 Here we report the discovery of extensive endochondral bone in Minjinia turgenensis, a new genus a

100 Endochondral bone is the main internal skeletal tissue o

101 ve network of fine trabeculae resembling the endochondral bone of osteichthyans.

102 The established dogma of endochondral bone ossification is that hypertrophic chon

103 hanism of valvular heart disease involves an endochondral bone process that is expressed as cartilage

104 mice showed delayed initiation and impaired endochondral bone repair, accompanied by a severe angiog

105 ge bone defects by closely mimicking natural endochondral bone repair.

106 2 and EP4 have differential functions during endochondral bone repair.

107 ralized area, and an inner, trabecular-like, endochondral bone, generated mainly by the human cells a

108 trophic cartilage that is destined to become endochondral bone.

109 was reduced and accompanied by decreases in endochondral bone.

110 d synovial joint formation in the developing endochondral bone.

111 (FGFR3) is expressed in the growth plate of endochondral bones and serves as a negative regulator of

112 The expanded array of distal endochondral bones and synovial joints in the fin of Tik

113 esenchymal condensations that give origin to endochondral bones are hypoxic during fetal development,

114 premature fusion of growth plates of various endochondral bones was evident, resulting in dwarfism in

115 In endochondral bones, the growth plate cartilage promotes

116 us growths projecting from the metaphyses of endochondral bones.

117 ge in a large area below the growth plate of endochondral bones.

118 ion and/or early anabolic progression during endochondral callus formation were investigated.

119 rophages promoted anabolic mechanisms during endochondral callus formation.

120 ssion of a dominant-negative MEF2C mutant in endochondral cartilage impairs hypertrophy, cartilage an

121 nd that local beta-NGF injections during the endochondral/cartilaginous phase promoted osteogenic mar

122 racellular matrix deposition in proximity to endochondral condensations (Sox9+) on the CAM-implanted

123 ys is associated with an increased number of endochondral distal radials.

124 FV 108) is represented by fin rays and three endochondral elements: other elements are not preserved.

125 on program analogous to that observed during endochondral embryonic skeletal development, with the po

126 Defective endochondral growth in TDII is associated with reduced p

127 whereas proximal elongation results from an endochondral growth plate.

128 ssential crossroad for joint development and endochondral growth.

129 A similar coinvasion occurs during endochondral healing of bone fractures.

130 raniofacial complex and also as the site for endochondral jaw bone growth.

131 and radiological assessment evidenced marked endochondral new bone formation leading to joint ankylos

132 ts within the CD9(+) population that lead to endochondral or intramembranous-like bone formation.

133 neration), the BMP-induced response involves endochondral ossification (redevelopment).

134 sing groups, particularly in MSX1/2, through endochondral ossification 6 weeks post-injection.

135 terminal phalanx forms late in gestation by endochondral ossification and continues to elongate unti

136 e for pRB and p107 in cartilage development, endochondral ossification and enchondroma formation that

137 e for pRB and p107 in cartilage development, endochondral ossification and enchondroma formation that

138 vo system to unlink the processes initiating endochondral ossification and establish more precisely t

139 ificial tissue undergoes intramembranous and endochondral ossification and forms a trabecular-like bo

140 ides in vivo evidence for the role of p38 in endochondral ossification and suggests that Sox9 is a li

141 on treatment with Wnt antagonists results in endochondral ossification and suture closure.

142 that syndecan 4 is functionally involved in endochondral ossification and that its loss impairs frac

143 rview of the processes of chondrogenesis and endochondral ossification and their control at the molec

144 els of active canonical Wnt signaling enable endochondral ossification and therefore PF-suture closur

145 ical Wnt signaling in the PF suture inhibits endochondral ossification and therefore, suture closure,

146 aggrecan C-type lectin domain in regulating endochondral ossification and, thereby, height.

147 ority of skeletal elements that form through endochondral ossification are absent, and the ones that

148 Chondrogenesis and endochondral ossification are precisely controlled by ce

149 Chondrogenesis and endochondral ossification are the cartilage differentiat

150 n and Has2 expression to control the rate of endochondral ossification as a negative feedback mechani

151 (P < 0.05), and had enhanced early and late endochondral ossification as demonstrated by Safranin O,

152 coagulation, Osteoclast differentiation and endochondral ossification as the major pathways associat

153 dentified a previously unrecognized delay in endochondral ossification associated with the loss of Gp

154 ion in hypertrophic chondrocytes accelerates endochondral ossification at both E17.5 and P1 stages.

155 that Phd2 expressed in chondrocytes inhibits endochondral ossification at the epiphysis by suppressin

156 how that redifferentiation does not occur by endochondral ossification but by the direct ossification

157 These alterations include accelerated endochondral ossification but delayed intramembranous os

158 Shn3 impairs growth plate maturation during endochondral ossification but simultaneously results in

159 minal differentiation of chondrocytes during endochondral ossification by activating the TGFalpha/EGF

160 , which drive the early steps of heterotopic endochondral ossification by lowering oxygen tension in

161 F signaling pathway plays essential roles in endochondral ossification by regulating osteoblast proli

162 Histone deacetylases (Hdacs) regulate endochondral ossification by suppressing gene transcript

163 Thus, the tight regulation of endochondral ossification by TBX1 is crucial for the nor

164 re we hypothesized that hMSCs pushed through endochondral ossification can engineer a scaled-up ossic

165 the oc/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast

166 This is followed by the formation of a new endochondral ossification center at the distal end of th

167 The endochondral ossification center contains proliferating

168 mmalian limb structures by stimulating a new endochondral ossification center that utilizes an existi

169 Using the polarity of the endochondral ossification centers induced by BMP2 at two

170 D673V mutation induces delayed endochondral ossification characterized by transiently r

171 Endochondral ossification depends on an avascular cartil

172 Moreover, physiological endochondral ossification did not occur, rather an ectop

173 data show that humans with CCD have altered endochondral ossification due to altered RUNX2 regulatio

174 es acts, at least in part, as a regulator of endochondral ossification during osteogenesis.

175 ibit chondrodysplasia and a complete lack of endochondral ossification even though Runx2 expression,

176 ion from mesenchymal stem cells in vitro and endochondral ossification ex vivo, and GEP-knockdown mic

177 vertebral segmentation, joint formation and endochondral ossification for this ubiquitously expresse

178 tal mandible or calvaria that do not undergo endochondral ossification formed only bone without marro

179 The classic model of endochondral ossification holds that chondrocytes mature

180 Indian hedgehog (Ihh) regulates endochondral ossification in both a parathyroid hormone-

181 in modern jawless fishes and the absence of endochondral ossification in early fossil gnathostomes a

182 Endochondral ossification in embryos from embryonic day

183 ng of terminal cartilage differentiation and endochondral ossification in mandibular condylar cartila

184 Endochondral ossification in the diaphysis of long bones

185 eralised fibro-cartilaginous metaplasia with endochondral ossification in the last case.

186 ever, whether Smad7 is actually required for endochondral ossification in vivo is unclear.

187 Endochondral ossification is a highly regulated process

188 loss of Foxc1 function mouse (Foxc1(ch/ch)), endochondral ossification is delayed and the expression

189 /-) mice during embryogenesis and found that endochondral ossification is significantly impaired due

190 Disruption to endochondral ossification leads to delayed and irregular

191 This suggests that two different forms of endochondral ossification occur.

192 analyze the functional role of syndecan 4 in endochondral ossification of mouse embryos and in adult

193 We investigated the role of Phd2 on endochondral ossification of the epiphyses by conditiona

194 Although endochondral ossification of the limb and axial skeleton

195 Endochondral ossification orchestrates formation of the

196 B-catalyzed proteoglycans regulate postnatal endochondral ossification partially through the mediatio

197 vidence for the association of these two key endochondral ossification pathway genes with BMD and ost

198 is study, we focused on two key genes in the endochondral ossification pathway, IBSP and PTHLH.

199 these animals appears to follow the classic endochondral ossification pathway.

200 Endochondral ossification plays an important role in the

201 Subarticular regions of endochondral ossification showed morphologic and calcifi

202 ion at the repair site during the periosteal endochondral ossification stage.

203 show a promotion in markers associated with endochondral ossification such as Ihh, Alpl, and Sdf-1.

204 TAP63a may promote endochondral ossification through interaction with genes

205 wounds with BMP2 in neonatal mice stimulates endochondral ossification to regenerate the stump bone.

206 ide, negatively regulates chondrogenesis and endochondral ossification via associating with progranul

207 Endochondral ossification was delayed in much of the Ihh

208 roses lacked typical growth plate zones, and endochondral ossification was delayed.

209 Endochondral ossification was not disrupted any further

210 vide a continuous supply of chondrocytes for endochondral ossification(1).

211 Endochondral ossification, an important process in verte

212 FR3) plays a critical role in the control of endochondral ossification, and bone growth and mutations

213 tional partner of Ihh-Gli2 signalling during endochondral ossification, and that disruption of the Fo

214 Collectively, our data implicate endochondral ossification, bone formation that proceeds

215 e regeneration via either intramembranous or endochondral ossification, both within and outside of th

216 bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the

217 During endochondral ossification, chondrocytes embed themselves

218 eoblasts and periosteal cells during primary endochondral ossification, consistent with a role in bon

219 hat Axin2(-/-) PF-sutures lack physiological endochondral ossification, contain ectopic cartilage and

220 During endochondral ossification, growth plate chondrocytes rel

221 , which contribute to suture closure through endochondral ossification, in a process regulated in par

222 ssion of Sox9, a major negative regulator of endochondral ossification, in Col2a1-TAP63alpha transgen

223 containing endothelial cell masses, abnormal endochondral ossification, leading to stunted long bone

224 thening, and repair of most bones proceed by endochondral ossification, namely through formation of a

225 ed structure that drives skeletal growth and endochondral ossification, remain unclear.

226 roplasia is a genetic disorder that inhibits endochondral ossification, resulting in disproportionate

227 spatiotemporal regulation in vitro resisted endochondral ossification, retained the expression of ca

228 During endochondral ossification, small, immature chondrocytes

229 During endochondral ossification, Spry genes are expressed in p

230 uppressing expression of factors involved in endochondral ossification, such as osterix and vascular

231 During endochondral ossification, the presence of fully formed

232 s to defects in cartilage development during endochondral ossification, the process by which long bon

233 e observed in the calvarium, indicating that endochondral ossification, the process needed for the fo

234 To investigate the role of this pathway in endochondral ossification, we generated transgenic mice

235 ouse posterior frontal (PF) suture closes by endochondral ossification, whereas sagittal (SAG) remain

236 elements blocks chondrocyte hypertrophy and endochondral ossification, whereas signaling starting at

237 ure (PF) of the cranial vault closes through endochondral ossification, while other sutures remain pa

238 ification, vascular invasion, and subsequent endochondral ossification.

239 ealing designed to therapeutically stimulate endochondral ossification.

240 mbrane-anchored metalloproteinase ADAM17, in endochondral ossification.

241 erein, DeltaNP63alpha and TAP63alpha, during endochondral ossification.

242 ypertrophic chondrocytes during growth plate endochondral ossification.

243 f primary ossification centers and disrupted endochondral ossification.

244 s, likely by reducing hedgehog signaling and endochondral ossification.

245 t is replaced by bone through the process of endochondral ossification.

246 were impaired in digit/limb development and endochondral ossification.

247 mous function of Atf4 in chondrocytes during endochondral ossification.

248 natriuretic peptide, a potent stimulator of endochondral ossification.

249 he proximal region of the mandible undergoes endochondral ossification.

250 osure of growth plates reflecting defects in endochondral ossification.

251 rmation of skeletal elements derived through endochondral ossification.

252 actor-I (IGF-I) is an important regulator of endochondral ossification.

253 for the genesis of normal cartilage and thus endochondral ossification.

254 ic secretion of HMGB1 in cartilage regulates endochondral ossification.

255 vertebral segmentation, joint formation and endochondral ossification.

256 equently fails in growth, chondrogenesis and endochondral ossification.

257 e destined for a chondrogenic lineage during endochondral ossification.

258 protein kinase (MAPK) pathway is involved in endochondral ossification.

259 ned role for Nell1 in signal transduction in endochondral ossification.

260 physes, also suggest an underlying defect in endochondral ossification.

261 Type I Collagen and Osteocalcin), suggesting endochondral ossification.

262 nization, cartilage boundary definition, and endochondral ossification.

263 and proper closure of the PF suture through endochondral ossification.

264 ferentiation during both intramembranous and endochondral ossification.

265 y distinct mechanisms in intramembranous and endochondral ossification.

266 that were distinct from archetypical physeal endochondral ossification.

267 ion and specification of intramembranous and endochondral ossification.

268 dgehog and collagen X, and failed to undergo endochondral ossification.

269 roduced by hypertrophic cartilage undergoing endochondral ossification.

270 rast, the isotropic control groups underwent endochondral ossification.

271 differentiation to osteoblasts and impaired endochondral ossification.

272 es heal predominantly through the process of endochondral ossification.

273 and the cranial base are both formed through endochondral ossification.

274 equired for chondrogenic differentiation and endochondral ossification.

275 th FGFR1 in hypertrophic chondrocytes during endochondral ossification.

276 bar vertebrae revealed delayed or incomplete endochondral ossification.

277 nal-induced chondrogenic differentiation and endochondral ossification.

278 hat the protein phosphatase Phlpp1 regulates endochondral ossification.

279 properly differentiate, leading to defective endochondral ossification.

280 cal role in chondrogenic differentiation and endochondral ossification.

281 nitors and proliferating chondrocytes during endochondral ossification.

282 nvolving Foxp1/2/4 may regulate Runx2 during endochondral ossification.

283 s play essential roles in crucial aspects of endochondral ossification: osteoblast differentiation, c

284 Extraskeletal bone forms through an endochondral process with a cartilage intermediary promp

285 al stem/stromal cells (hMSCs) can execute an endochondral program and ectopically generate mature bon

286 we demonstrate beta-NGF's ability to promote endochondral repair in a murine model and uncover mechan

287 hedgehog (Ihh) controls multiple aspects of endochondral skeletal development by signaling to both c

288 ling simultaneously in the same cells during endochondral skeletal development using beta-catenin and

289 hedgehog (Ihh) controls multiple aspects of endochondral skeletal development, including proliferati

290 ate all major aspects of Ihh function during endochondral skeletal development.

291 Ihh signaling in the absence of PTHrP during endochondral skeletal development.

292 The carapace contains axial endochondral skeletal elements and exoskeletal dermal bo

293 rs that have previously been associated with endochondral skeleton development to define the cellular

294 oteins, is essential for osteogenesis in the endochondral skeleton during embryogenesis.

295 ential for osteoblast differentiation in the endochondral skeleton during embryogenesis.

296 ntiation during embryonic development of the endochondral skeleton.

297 tioning of interphalangeal joints within the endochondral skeleton.

298 h), a locally produced growth signal for the endochondral skeleton.

299 However, its endochondral space is filled with an extensive network o

300 ables the spatial and temporal prediction of endochondral tissue regeneration, assessed as areas of c