ライフサイエンスコーパス: endochondral ossification

1 mous function of Atf4 in chondrocytes during endochondral ossification.

2 he proximal region of the mandible undergoes endochondral ossification.

3 osure of growth plates reflecting defects in endochondral ossification.

4 rmation of skeletal elements derived through endochondral ossification.

5 actor-I (IGF-I) is an important regulator of endochondral ossification.

6 for the genesis of normal cartilage and thus endochondral ossification.

7 ic secretion of HMGB1 in cartilage regulates endochondral ossification.

8 vertebral segmentation, joint formation and endochondral ossification.

9 equently fails in growth, chondrogenesis and endochondral ossification.

10 e destined for a chondrogenic lineage during endochondral ossification.

11 protein kinase (MAPK) pathway is involved in endochondral ossification.

12 ned role for Nell1 in signal transduction in endochondral ossification.

13 physes, also suggest an underlying defect in endochondral ossification.

14 Type I Collagen and Osteocalcin), suggesting endochondral ossification.

15 nization, cartilage boundary definition, and endochondral ossification.

16 and proper closure of the PF suture through endochondral ossification.

17 ferentiation during both intramembranous and endochondral ossification.

18 y distinct mechanisms in intramembranous and endochondral ossification.

19 ion and specification of intramembranous and endochondral ossification.

20 dgehog and collagen X, and failed to undergo endochondral ossification.

21 roduced by hypertrophic cartilage undergoing endochondral ossification.

22 that were distinct from archetypical physeal endochondral ossification.

23 peared to be required for the progression of endochondral ossification.

24 sterior cranium and other bones derived from endochondral ossification.

25 now determined the role of EGFR signaling in endochondral ossification.

26 ndrium and the vasculature are essential for endochondral ossification.

27 ormed within a soft connective tissue, or by endochondral ossification.

28 n, as well as chondrocyte maturation, during endochondral ossification.

29 th overlapping and distinct functions during endochondral ossification.

30 ocyte hypertrophy is a mandatory step during endochondral ossification.

31 a change of matrilin oligomeric forms during endochondral ossification.

32 rast, the isotropic control groups underwent endochondral ossification.

33 ly as embryonic day 14, during initiation of endochondral ossification.

34 on to its co-assembly with matrilin-1 during endochondral ossification.

35 both chondrogenesis and osteogenesis during endochondral ossification.

36 owed by mineralizing chondrocytes undergoing endochondral ossification.

37 or, a signaling molecule that also regulates endochondral ossification.

38 fgfr3 gene expression during the process of endochondral ossification.

39 nar structures of chondrocytes and defective endochondral ossification.

40 ot express RARgamma, and were not undergoing endochondral ossification.

41 oduces a delay in chondrocyte maturation and endochondral ossification.

42 with other signaling pathways that regulate endochondral ossification.

43 enchyme, but not in cartilages formed during endochondral ossification.

44 ized by short-limbed dwarfism and a delay in endochondral ossification.

45 properly differentiate, leading to defective endochondral ossification.

46 differentiation to osteoblasts and impaired endochondral ossification.

47 development, indicating a role for Acp 5 in endochondral ossification.

48 imal skeletal elements that fail to initiate endochondral ossification.

49 ne this with public data to form an atlas of endochondral ossification.

50 road anatomical domain of FAP recruitment to endochondral ossification.

51 es heal predominantly through the process of endochondral ossification.

52 condensing mesenchyme cells at the onset of endochondral ossification.

53 ory networks that govern intramembranous and endochondral ossification.

54 and the cranial base are both formed through endochondral ossification.

55 equired for chondrogenic differentiation and endochondral ossification.

56 th FGFR1 in hypertrophic chondrocytes during endochondral ossification.

57 bar vertebrae revealed delayed or incomplete endochondral ossification.

58 nal-induced chondrogenic differentiation and endochondral ossification.

59 hat the protein phosphatase Phlpp1 regulates endochondral ossification.

60 cal role in chondrogenic differentiation and endochondral ossification.

61 ealing designed to therapeutically stimulate endochondral ossification.

62 nitors and proliferating chondrocytes during endochondral ossification.

63 nvolving Foxp1/2/4 may regulate Runx2 during endochondral ossification.

64 ification, vascular invasion, and subsequent endochondral ossification.

65 mbrane-anchored metalloproteinase ADAM17, in endochondral ossification.

66 erein, DeltaNP63alpha and TAP63alpha, during endochondral ossification.

67 ypertrophic chondrocytes during growth plate endochondral ossification.

68 f primary ossification centers and disrupted endochondral ossification.

69 s, likely by reducing hedgehog signaling and endochondral ossification.

70 natriuretic peptide, a potent stimulator of endochondral ossification.

71 t is replaced by bone through the process of endochondral ossification.

72 were impaired in digit/limb development and endochondral ossification.

73 vide a continuous supply of chondrocytes for endochondral ossification(1).

74 sing groups, particularly in MSX1/2, through endochondral ossification 6 weeks post-injection.

75 of schemes for the synchrony of cortical and endochondral ossification among vertebrates.

76 Endochondral ossification, an important process in verte

77 A dramatic impairment of endochondral ossification and an attenuation of longitud

78 This impacts on the rate of endochondral ossification and bone formation and suggest

79 misregulated expression of genes related to endochondral ossification and chondrogenic commitment in

80 terminal phalanx forms late in gestation by endochondral ossification and continues to elongate unti

81 e for pRB and p107 in cartilage development, endochondral ossification and enchondroma formation that

82 e for pRB and p107 in cartilage development, endochondral ossification and enchondroma formation that

83 vo system to unlink the processes initiating endochondral ossification and establish more precisely t

84 sed hypertrophic domains as well as delay in endochondral ossification and formation and vascularizat

85 ificial tissue undergoes intramembranous and endochondral ossification and forms a trabecular-like bo

86 monstrate that Fgfr3 is essential for normal endochondral ossification and inner ear development.

87 Cartilage provides the template for endochondral ossification and is crucial for determining

88 omotes chondrocyte death, preventing further endochondral ossification and joint development.

89 Unregulated FGF signaling affects endochondral ossification and long bone growth, causing

90 ides in vivo evidence for the role of p38 in endochondral ossification and suggests that Sox9 is a li

91 on treatment with Wnt antagonists results in endochondral ossification and suture closure.

92 that syndecan 4 is functionally involved in endochondral ossification and that its loss impairs frac

93 rview of the processes of chondrogenesis and endochondral ossification and their control at the molec

94 els of active canonical Wnt signaling enable endochondral ossification and therefore PF-suture closur

95 ical Wnt signaling in the PF suture inhibits endochondral ossification and therefore, suture closure,

96 aggrecan C-type lectin domain in regulating endochondral ossification and, thereby, height.

97 FR3) plays a critical role in the control of endochondral ossification, and bone growth and mutations

98 oreseen link between hypertrophic cartilage, endochondral ossification, and establishment of the marr

99 tional partner of Ihh-Gli2 signalling during endochondral ossification, and that disruption of the Fo

100 ority of skeletal elements that form through endochondral ossification are absent, and the ones that

101 Mechanisms of endochondral ossification are conserved across growth pl

102 , but their roles in chondrocytes to control endochondral ossification are less clear.

103 Chondrogenesis and endochondral ossification are precisely controlled by ce

104 Chondrogenesis and endochondral ossification are the cartilage differentiat

105 n and Has2 expression to control the rate of endochondral ossification as a negative feedback mechani

106 (P < 0.05), and had enhanced early and late endochondral ossification as demonstrated by Safranin O,

107 coagulation, Osteoclast differentiation and endochondral ossification as the major pathways associat

108 dentified a previously unrecognized delay in endochondral ossification associated with the loss of Gp

109 ion in hypertrophic chondrocytes accelerates endochondral ossification at both E17.5 and P1 stages.

110 natal viability and growth, with a defect in endochondral ossification at epiphyseal plates similar t

111 g to proximal FH cartilage calcification and endochondral ossification at the distal femur.

112 that Phd2 expressed in chondrocytes inhibits endochondral ossification at the epiphysis by suppressin

113 Endochondral ossification begins from the condensation a

114 Collectively, our data implicate endochondral ossification, bone formation that proceeds

115 e regeneration via either intramembranous or endochondral ossification, both within and outside of th

116 how that redifferentiation does not occur by endochondral ossification but by the direct ossification

117 These alterations include accelerated endochondral ossification but delayed intramembranous os

118 Shn3 impairs growth plate maturation during endochondral ossification but simultaneously results in

119 bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the

120 Limbs and vertebrae elongate by endochondral ossification, but local growth control is h

121 minal differentiation of chondrocytes during endochondral ossification by activating the TGFalpha/EGF

122 Thus, FGFR-3 appears to regulate endochondral ossification by an essentially negative mec

123 rmone (PTH) and its related peptide regulate endochondral ossification by inhibiting chondrocyte diff

124 , which drive the early steps of heterotopic endochondral ossification by lowering oxygen tension in

125 F signaling pathway plays essential roles in endochondral ossification by regulating osteoblast proli

126 Histone deacetylases (Hdacs) regulate endochondral ossification by suppressing gene transcript

127 Thus, the tight regulation of endochondral ossification by TBX1 is crucial for the nor

128 re we hypothesized that hMSCs pushed through endochondral ossification can engineer a scaled-up ossic

129 Mutant limbs showed impaired endochondral ossification, cartilage overgrowth, and abn

130 complement protein C3 is reported to control endochondral ossification, cartilage-to-bone transition,

131 the oc/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast

132 ort limbs, a defect attributable to abnormal endochondral ossification caused by delayed cell cycle e

133 This is followed by the formation of a new endochondral ossification center at the distal end of th

134 The endochondral ossification center contains proliferating

135 mmalian limb structures by stimulating a new endochondral ossification center that utilizes an existi

136 Using the polarity of the endochondral ossification centers induced by BMP2 at two

137 D673V mutation induces delayed endochondral ossification characterized by transiently r

138 During endochondral ossification, chondrocytes embed themselves

139 ne mass (osteopetrosis), or abnormalities in endochondral ossification (chondrodysplasias).

140 eoblasts and periosteal cells during primary endochondral ossification, consistent with a role in bon

141 hat Axin2(-/-) PF-sutures lack physiological endochondral ossification, contain ectopic cartilage and

142 In conclusion, endochondral ossification defects and reduced number of

143 Endochondral ossification depends on an avascular cartil

144 lect cell-type-specific expression along the endochondral ossification developmental trajectory.

145 Moreover, physiological endochondral ossification did not occur, rather an ectop

146 data show that humans with CCD have altered endochondral ossification due to altered RUNX2 regulatio

147 scribe a ninein knockout mouse with advanced endochondral ossification during embryonic development.

148 es acts, at least in part, as a regulator of endochondral ossification during osteogenesis.

149 ibit chondrodysplasia and a complete lack of endochondral ossification even though Runx2 expression,

150 ion from mesenchymal stem cells in vitro and endochondral ossification ex vivo, and GEP-knockdown mic

151 vertebral segmentation, joint formation and endochondral ossification for this ubiquitously expresse

152 tal mandible or calvaria that do not undergo endochondral ossification formed only bone without marro

153 ty, suppressed osteogenesis, activated early endochondral ossification genes after 3 d of culture in

154 During endochondral ossification, growth plate chondrocytes rel

155 The classic model of endochondral ossification holds that chondrocytes mature

156 During this process of endochondral ossification, hypertrophic cartilage expres

157 formed that grew in mass and cellularity by endochondral ossification in a manner similar to normal

158 Indian hedgehog (Ihh) regulates endochondral ossification in both a parathyroid hormone-

159 ation genes throughout the entire process of endochondral ossification in chondrocyte-specific Foxc1/

160 ients with FOP develop ectopic bones through endochondral ossification in craniofacial regions.

161 in modern jawless fishes and the absence of endochondral ossification in early fossil gnathostomes a

162 Endochondral ossification in embryos from embryonic day

163 logy of how skeletogenic cells contribute to endochondral ossification in FOP remains unknown.

164 drocytes induced chondrocyte hypertrophy and endochondral ossification in locations where it normally

165 ng of terminal cartilage differentiation and endochondral ossification in mandibular condylar cartila

166 on of the chondrocyte maturation process and endochondral ossification in the developing limb.

167 Endochondral ossification in the diaphysis of long bones

168 eralised fibro-cartilaginous metaplasia with endochondral ossification in the last case.

169 fferentiation of chondrocytes that initiates endochondral ossification in the midsection of endochond

170 ever, whether Smad7 is actually required for endochondral ossification in vivo is unclear.

171 rtrophy-like stage, which shared features of endochondral ossification in vivo.

172 The process of endochondral ossification in which the bones of the limb

173 , which contribute to suture closure through endochondral ossification, in a process regulated in par

174 ssion of Sox9, a major negative regulator of endochondral ossification, in Col2a1-TAP63alpha transgen

175 estigated as drugs for inhibition of ectopic endochondral ossification, including osteochondromas.

176 Endochondral ossification initiates the growth of the ma

177 Endochondral ossification is a highly regulated process

178 Endochondral ossification is a major mode of bone that o

179 loss of Foxc1 function mouse (Foxc1(ch/ch)), endochondral ossification is delayed and the expression

180 Ctgf mutant growth plates are expanded, and endochondral ossification is impaired.

181 erefore, gene expression of ccn2 mRNA during endochondral ossification is properly regulated, at leas

182 /-) mice during embryogenesis and found that endochondral ossification is significantly impaired due

183 Longitudinal bone growth, achieved through endochondral ossification, is accomplished by a cartilag

184 containing endothelial cell masses, abnormal endochondral ossification, leading to stunted long bone

185 Disruption to endochondral ossification leads to delayed and irregular

186 thening, and repair of most bones proceed by endochondral ossification, namely through formation of a

187 This suggests that two different forms of endochondral ossification occur.

188 eleton arises from the continuous process of endochondral ossification occurring at the ends of growi

189 any inflammatory reaction, and they form by endochondral ossification of enthesis fibrocartilage.

190 analyze the functional role of syndecan 4 in endochondral ossification of mouse embryos and in adult

191 adipogenesis of multipotent cells and early endochondral ossification of nonadipogenic cells, wherea

192 Both intramembranous and endochondral ossification of the cranial vault were dela

193 We investigated the role of Phd2 on endochondral ossification of the epiphyses by conditiona

194 This mutation leads to impaired endochondral ossification of the human skeleton.

195 Although endochondral ossification of the limb and axial skeleton

196 on embryonic days 10.5-12.5 and to sites of endochondral ossification on embryonic days 12.5 and 13.

197 uld express transcription factors related to endochondral ossification, only BMSCs formed cartilage d

198 nous chondrocranium is transient, undergoing endochondral ossification or disappearing, so its role i

199 Endochondral ossification orchestrates formation of the

200 s play essential roles in crucial aspects of endochondral ossification: osteoblast differentiation, c

201 B-catalyzed proteoglycans regulate postnatal endochondral ossification partially through the mediatio

202 vidence for the association of these two key endochondral ossification pathway genes with BMD and ost

203 is study, we focused on two key genes in the endochondral ossification pathway, IBSP and PTHLH.

204 these animals appears to follow the classic endochondral ossification pathway.

205 Endochondral ossification plays an important role in the

206 ively differentiate and the tissue undergoes endochondral ossification, recapitulating the developmen

207 neration), the BMP-induced response involves endochondral ossification (redevelopment).

208 ed structure that drives skeletal growth and endochondral ossification, remain unclear.

209 roplasia is a genetic disorder that inhibits endochondral ossification, resulting in disproportionate

210 of IL-1Ra occurred via the native process of endochondral ossification, resulting in improved quality

211 spatiotemporal regulation in vitro resisted endochondral ossification, retained the expression of ca

212 Subarticular regions of endochondral ossification showed morphologic and calcifi

213 During endochondral ossification, small, immature chondrocytes

214 During endochondral ossification, Spry genes are expressed in p

215 ion at the repair site during the periosteal endochondral ossification stage.

216 show a promotion in markers associated with endochondral ossification such as Ihh, Alpl, and Sdf-1.

217 uppressing expression of factors involved in endochondral ossification, such as osterix and vascular

218 he replacement of cartilage by bones through endochondral ossification, the growth of long bones thro

219 During endochondral ossification, the presence of fully formed

220 s to defects in cartilage development during endochondral ossification, the process by which long bon

221 e observed in the calvarium, indicating that endochondral ossification, the process needed for the fo

222 During the initiation of endochondral ossification three events occur that are in

223 TAP63a may promote endochondral ossification through interaction with genes

224 wounds with BMP2 in neonatal mice stimulates endochondral ossification to regenerate the stump bone.

225 nin O staining of cartilage formation in the endochondral ossification under hyperglycemic condition

226 brate cranial base and limb skeleton grow by endochondral ossification, under the control of growth p

227 ide, negatively regulates chondrogenesis and endochondral ossification via associating with progranul

228 Endochondral ossification was delayed in much of the Ihh

229 roses lacked typical growth plate zones, and endochondral ossification was delayed.

230 Endochondral ossification was not disrupted any further

231 To investigate the role of this pathway in endochondral ossification, we generated transgenic mice

232 - and PTHrP-receptor-mediated signals during endochondral ossification were examined with embryonic m

233 in the growth plates and a general delay in endochondral ossification, whereas chondrocyte prolifera

234 cmRNA regenerated bone via endochondral ossification, whereas rhBMP-2 drove intrame

235 ouse posterior frontal (PF) suture closes by endochondral ossification, whereas sagittal (SAG) remain

236 elements blocks chondrocyte hypertrophy and endochondral ossification, whereas signaling starting at

237 ure (PF) of the cranial vault closes through endochondral ossification, while other sutures remain pa

238 tical growth of the mandibular ramus through endochondral ossification with distinctive modes of cell

239 DDR2(+) CSCs mediate a distinct form of endochondral ossification without the typical haematopoi