ライフサイエンスコーパス: endocrine cell

1 pancreatic cells (including functional islet endocrine cells).

2 o (hepatocytes) and in vivo (hepatocytes and endocrine cells).

3 ions of cellular heterogeneity in pancreatic endocrine cells.

4 notropin (alpha-MSH)], and with somatolactin endocrine cells.

5 hESC-gut tube intermediates into pancreatic endocrine cells.

6 sma and for assaying hormone secretions from endocrine cells.

7 G3 is sufficient for formation of pancreatic endocrine cells.

8 ted lineage-specific generation of acinar or endocrine cells.

9 are secretory vesicles found in neurons and endocrine cells.

10 , rather than promoted, growth in pancreatic endocrine cells.

11 e pancreas, ST18 expression is restricted to endocrine cells.

12 atively regulates the proliferation of early endocrine cells.

13 ral mucous cells, and a diversity of gastric endocrine cells.

14 fect the specification of hormone-expressing endocrine cells.

15 sing neuronal genes during the maturation of endocrine cells.

16 rbohydrate, lipid and protein sensing in gut endocrine cells.

17 s most radioactivity remained trapped in the endocrine cells.

18 he regulated secretory pathway of neural and endocrine cells.

19 urther develops in vivo to mature pancreatic endocrine cells.

20 e paracrine cholinergic input to surrounding endocrine cells.

21 large islets consisting of several thousand endocrine cells.

22 sting oscillations are common in neurons and endocrine cells.

23 ductal cells, centroacinar cells (CACs) and endocrine cells.

24 mediate cAMP-stimulated exocytosis in other endocrine cells.

25 ined to become the adult midgut is devoid of endocrine cells.

26 trapancreatic duct is the main source of new endocrine cells.

27 on and repression of cytokines in pancreatic endocrine cells.

28 ration and antiapoptosis in nonendocrine and endocrine cells.

29 eatic development and the differentiation of endocrine cells.

30 and wild-type prohormones in CNS neurons and endocrine cells.

31 y as human islets and stained positively for endocrine cells.

32 novel mutational signature in healthy aging endocrine cells.

33 activating other MAP kinases in neuronal and endocrine cells.

34 iate or become reprogrammed into other islet endocrine cells.

35 ches (termed periphery), produces most islet endocrine cells.

36 ed to epithelial and chromogranin A-positive endocrine cells.

37 f differentiated cells, including goblet and endocrine cells.

38 s found in secretory vesicles in neurons and endocrine cells.

39 three epithelial tissues: a partial loss of endocrine cells, a disrupted ductal tree and a >90% defi

40 late blood glucose homeostasis by regulating endocrine cell activity in the pancreatic islets of Lang

41 acing, we demonstrated that CACs do form new endocrine cells after beta-cell ablation or partial panc

42 lines were unable to form mature pancreatic endocrine cells after engraftment of PDX1(+)/NKX6.1(+) p

43 gets of NeuroD1 in intestinal and pancreatic endocrine cells, all show similar promoter occupancy by

44 Morphometric analysis also revealed endocrine cell allocation and architectural similarities

45 trointestinal (GI) hormones from specialized endocrine cells along the GI tract.

46 natally, an increase in the proliferation of endocrine cells also participates in their expansion.

47 We identified 118 alpha, 105 beta, 6 delta endocrine cells and 47 exocrine cells.

48 ndividual DCVs has been imaged in vitro with endocrine cells and at the neuron soma, growth cones, ne

49 lls, representative of developing pancreatic endocrine cells and beta-cells, respectively, was also d

50 ration and differentiation of epithelial and endocrine cells and cancers.

51 potent by embryonic day 13.5, giving rise to endocrine cells and ductal cells.

52 derm of the early embryo where precursors of endocrine cells and enterocytes of the larval midgut, as

53 rcuits reveals genes critical for generating endocrine cells and identifies circadian control as limi

54 able re-aggregation technique to deplete non-endocrine cells and identify CD49a (also known as ITGA1)

55 TSG-6 was observed within the islet endocrine cells and in inflammatory infiltrates.

56 sed predominantly on hepatocytes, pancreatic endocrine cells and intestinal cells.

57 le membrane protein expressed in neurons and endocrine cells and involved in the regulation of neurot

58 ulates incretin hormone release from colonic endocrine cells and is implicated in macrophage and adip

59 ed robustly upon differentiation into mature endocrine cells and localized to both alpha and beta cel

60 merging is mediated is poorly understood in endocrine cells and neurons containing small approximate

61 Notch signaling represses differentiation of endocrine cells and promotes proliferation of Nkx6-1(+)P

62 n secretory granules which store hormones in endocrine cells and release them upon cell stimulation.

63 s suggests direct interactions between islet endocrine cells and surrounding cells as well as the bid

64 Markers of endocrine cells and their progenitors were studied by im

65 ure and give rise to hepatocytes, pancreatic endocrine cells, and intestinal epithelial cells when tr

66 In contrast, Prox1-positive endocrine cells appear as primary sensors of cholinergic

67 levels of endogenous GLP-1 secreted from gut endocrine cells are capable of augmenting glucoregulator

68 erentiation is reduced in Sox2 mutants, some endocrine cells are generated, such as POMC-positive cel

69 Endocrine cells are properly specified in Tshz1-null emb

70 in pancreatic progenitors results in reduced endocrine cell area at birth due to impaired endocrine c

71 In conclusion, although endocrine cells arise from the Sox9(+) ductal domain thr

72 of the developing pancreas (associated with endocrine cells) as early as embryonic day 12.5 (E12.5)

73 ctroscopic features suggestive of pancreatic endocrine cells, as well as assessing the homogeneity of

74 e cells nonautonomously regulate the flux of endocrine cell birth as well as proliferative growth of

75 +) pancreatic progenitors (PPs) give rise to endocrine cells both in vitro and in vivo.

76 ptide 1 (GLP-1) is expressed not only in gut endocrine cells, but also in cells in the caudal brainst

77 tion from a ductal progenitor to a committed endocrine cell by repressing a progenitor cell program a

78 s competent to differentiate into ductal and endocrine cells by inducing activators of cell different

79 dicate that CACs are more closely related to endocrine cells by lineage as they share a common progen

80 neurotransmitter secretion from neuronal and endocrine cells by pharmacological and molecular manipul

81 ndicate that fully differentiated pancreatic endocrine cells can be created via stepwise differentiat

82 ting insulin(+) cells, suggesting that islet endocrine cells can intercalate into hyperplastic ducts

83 articular, we have focused on recapitulating endocrine cell clustering by isolating and reaggregating

84 Notably, endocrine cell clustering induces metabolic maturation b

85 In summary, replicating aspects of endocrine cell clustering permits the generation of stem

86 ntified multifocal aberrant crypt-containing endocrine cell clusters (ACECs) that contain crypt EC ce

87 within islets compared with sub-islet-sized endocrine cell clusters and among pancreatic lobes.

88 y system to pancreas, with formation of many endocrine cell clusters of the type found in normal isle

89 est and most diverse population of mammalian endocrine cells, comprise a number of different cell typ

90 Notably, postnatal expansion of the endocrine cell content was extremely poor, and the mutan

91 Very small numbers of non-beta endocrine cells continue to arise from Sox9(+) cells in

92 Within the human pancreas, exocrine and endocrine cells control secretion of digestive enzymes a

93 the gene encoding Foxo1 in mouse intestinal endocrine cells converts them into cells synthesizing an

94 Endocrine cells costaining for insulin and glucagon were

95 We propose that dedifferentiation trumps endocrine cell death in the natural history of beta cell

96 ally, in vitro differentiation of pancreatic endocrine cells derived from human pluripotent stem cell

97 velopment within pancreatic islets, in which endocrine cell-derived VEGF directs the patterning of in

98 tiation diminishes shortly after birth, when endocrine cells detach from the epithelial lining of the

99 novel and conserved role of Arx in mammalian endocrine cell development and provide a potential cause

100 In contrast, neither endocrine cell development nor function was affected in

101 The third step of entero-endocrine cell development takes place at a mid-pupal st

102 etter define the role of Insm1 in pancreatic endocrine cell development we generated mice with an Ins

103 d several transcription factors important in endocrine cell development, including Ngn3, MafA, and Pd

104 on factor involved in duct morphogenesis and endocrine cell development, is downstream Hnf1b.

105 advances in our understanding of pancreatic endocrine cell development, the function of the pancreat

106 d a reduction, but not a loss, of pancreatic endocrine cell development.

107 und that nine are dispensable for pancreatic endocrine cell development.

108 insulin- and glucagon-producing cells during endocrine cell development.

109 expression during late stages of pancreatic endocrine cell development.

110 ebrafish pancreas matures, hormone-producing endocrine cells differentiate from pancreatic Notch-resp

111 f Pax4 opened new avenues of research in the endocrine cell differentiation and diabetes fields.

112 E16.5, the increased EC population perturbed endocrine cell differentiation and islet cell clustering

113 endocrine cell area at birth due to impaired endocrine cell differentiation and reduced prenatal prol

114 1 inhibition, suggesting that LSD1 regulates endocrine cell differentiation by limiting the duration

115 ols the choice between absorptive and entero-endocrine cell differentiation in both the mammalian sma

116 te during epithelial maturation within which endocrine cell differentiation is continually robust and

117 her determine that RA-mediated regulation of endocrine cell differentiation occurs through Wnt pathwa

118 identify a transient requirement for LSD1 in endocrine cell differentiation spanning a short time-win

119 SPR/Cas9-mediated gene editing, coupled with endocrine cell differentiation strategies, we dissect th

120 gulate early endoderm patterning and gastric endocrine cell differentiation upstream of the transcrip

121 tiation, with inhibition inducing mucous and endocrine cell differentiation while activation reduced

122 3 (Ngn3) plays a critical role in pancreatic endocrine cell differentiation, although regulation of N

123 ranscription factor Ngn3, a key regulator of endocrine cell differentiation.

124 play strong inhibitory effects on subsequent endocrine cell differentiation.

125 roper induction of NEUROG3 and initiation of endocrine cell differentiation.

126 tly different from humans, canine pancreatic endocrine cell distribution is more similar.

127 other major pancreatic cell types including endocrine cells, duct cells and endothelial cells.

128 Mechanisms of the expansion of endocrine cells during embryonic development are not com

129 These data suggest that clustering of endocrine cells during islet morphogenesis is guided, at

130 f, like Pax6, is expressed in all pancreatic endocrine cells during mouse postnatal development and i

131 ferentiation into enterocytes (EC) or entero-endocrine cells (EE).

132 st time, we address the role of cell size in endocrine cell electrical activity, finding that larger

133 y for monitoring early changes in pancreatic endocrine cells eventually leading to T1D.

134 ly, in vivo- but not in vitro-differentiated endocrine cells exhibit close similarity to primary huma

135 t the in vivo maturation period hESC-derived endocrine cells exhibited gene and protein expression pr

136 Pancreatic endocrine cells expand rapidly during embryogenesis by n

137 filing showed that that the Dicer1-deficient endocrine cells expressed neuronal genes before the onse

138 -enriched pattern of Ldb1 was similar to pan-endocrine cell-expressed Islet-1 (Isl1), which was demon

139 ers are closely associated with gonadotropic endocrine cells [expressing luteinizing hormone (LH) and

140 a noncanonical action for Notch2 protein in endocrine cell fate selection, and demonstrate that acqu

141 sms by which RA signaling directs pancreatic endocrine cell fate.

142 show how pervasive epigenetic priming steers endocrine cell fates.

143 s express NEUROG3 but do not adopt alternate endocrine cell fates.

144 h, we demonstrated these progenitors produce endocrine cells following inhibition of RA signaling.

145 These new endocrine cells form small clusters known as secondary (

146 of the challenging organs to study, in which endocrine cells form various sizes of islets that are sc

147 ROD1 promoter in vitro and to induce ectopic endocrine cell formation and cell delamination after in

148 e RT-PCR, to simultaneously track pancreatic endocrine cell frequencies and phenotypes during a T-cel

149 We find that islet endocrine cells from older donors display increased leve

150 expression, thereby allowing delamination of endocrine cells from the trunk epithelium and revealing

151 ics during the induction of human pancreatic endocrine cells, from which we develop a lineage model o

152 rotransmitters may extend beyond controlling endocrine cell function to work as signals modulating va

153 pha cell gene expression signature, maintain endocrine cell function, and regulate cellular metabolis

154 implying continued essential roles in mature endocrine cell function.

155 Analysis of endocrine cell gene expression in the absence of neural

156 NEUROG3, is an essential variable in normal endocrine cell genesis.

157 Deletion of Mtor in pancreatic endocrine cells had no significant effect on their embry

158 consequently, differentiation of pancreatic endocrine cells has been restricted to embryonic develop

159 cagon plays an important role in maintaining endocrine cell homeostasis through feedback mechanisms t

160 nto embryonic fates or adopt alternate islet endocrine cell identities.

161 vel cAMP effector, expressed in neuronal and endocrine cells in adult mammals, that is required for D

162 bryogenesis but become much more enriched in endocrine cells in adults, implying continued essential

163 CTLA-4 antigen was expressed by pituitary endocrine cells in all patients but at different levels.

164 e the differentiation of a limited number of endocrine cells in either organ when activated in Ngn3(+

165 The non-beta endocrine cells in pancreatic islets play an essential c

166 ells to detect neurotransmitter release from endocrine cells in real-time.

167 ffect of microbial metabolites on pancreatic endocrine cells in regulating type 1 diabetes pathophysi

168 is secreted into circulation from the gut L-endocrine cells in response to food intake, thus inducin

169 derived peptides that are released from gut endocrine cells in response to nutrient intake.

170 mach revealed that a significant fraction of endocrine cells in the gastric corpus did not arise from

171 elix (bHLH) protein NeuroD1 is restricted to endocrine cells in the gastrointestinal (GI) tract, wher

172 central nervous system in invertebrates and endocrine cells in the gut or pancreas in vertebrates.

173 In adipocytes, one of the most abundant endocrine cells in the human body, the de novo productio

174 ription factor involved in the production of endocrine cells in the intestine and pancreas of humans

175 stasis and is produced by highly specialized endocrine cells in the kidney, known as juxtaglomerular

176 Notch signaling inhibits differentiation of endocrine cells in the pancreas and intestine.

177 eostasis is coordinated by hormone-secreting endocrine cells in the pancreas, as well as glucose util

178 Endocrine cells in the pituitary gland typically display

179 disproportionately inhibit the formation of endocrine cells in the remnant pancreas.

180 detectible NEUROG3 protein and did not form endocrine cells in vitro.

181 progenitors can self-renew and give rise to endocrine cells in vivo, suggesting that they are tissue

182 These endocrine cells include the insulin-producing beta-cells

183 duct cells and longer-term reprogramming to endocrine cells, including insulin(+) beta-cells that ar

184 leads to a dramatic loss of endoderm-derived endocrine cells, including insulin-secreting beta-cells,

185 nt and give rise to duct cells and late-born endocrine cells, including the insulin producing beta-ce

186 ple, T2Rs are found in some gastrointestinal endocrine cells, including those that secrete the peptid

187 gh expression levels of many genes common to endocrine cells, including transcription factors, hormon

188 In vitro tracer uptake in endocrine cells (INS-1 and human islets), but not PANC1

189 dings indicate that in developing pancreatic endocrine cells Insm1 promotes the transition from a duc

190 etabolism, and diabetes onset, but how islet endocrine cells interact with sensory neurons has not be

191 nt activation of MAP kinases in neuronal and endocrine cells is critical for cell differentiation and

192 (2) the level of VEGF-A production by islet endocrine cells is critical for islet vascularization du

193 that trafficking of steroid hormones out of endocrine cells is not always through a simple diffusion

194 ersion of human pancreatic exocrine cells to endocrine cells is novel and represents a safer and simp

195 al variability, i.e. regional differences in endocrine cell/islet distribution, and marked inter-indi

196 both within the islet and outside the islet endocrine cells, juxtaposed to islet microvessels in T1D

197 exus state to ensure prolonged allocation of endocrine cells late into gestation.

198 internalization studies using the pancreatic endocrine cell line INR1G9 transfected with the human GI

199 N (hNT/N) gene expression in the novel human endocrine cell line, BON, which resembles intestinal N c

200 Therefore, the process of islet endocrine cell lineage allocation is critical to ensure

201 ion factor is critical in the development of endocrine cell lineage.

202 of distinct populations of hormone-producing endocrine cell lineages in the anterior/intermediate pit

203 ions of Nkx2.2 and Arx in the development of endocrine cell lineages, we generated progenitor cell-sp

204 ing genes that specify the alternative islet endocrine cell lineages.

205 nabled pseudo-entry virus infects pancreatic endocrine cells, liver organoids, cardiomyocytes, and do

206 -cell dedifferentiation, and not necessarily endocrine cell loss, constitutes a major cause of beta-c

207 We show that endocrine cells maintain their identity in culture in th

208 exit of the cell cycle and the expression of endocrine cell markers during differentiation, we invest

209 Endocrine cell mass and proliferation rates were unalter

210 morphogenesis, which subsequently determines endocrine cell mass.

211 nd is progressively lost from alpha-cells as endocrine cells mature into adulthood.

212 nd pseudo-plateau bursting patterns found in endocrine cell models that are characterized by a super-

213 s and bihormonal cells that displayed hybrid endocrine cell morphological characteristics.

214 n3 (Ngn3) is a key determinant of pancreatic endocrine cell neogenesis during embryogenesis, many stu

215 t-conducting A fibers that contact pulmonary endocrine cells (neuroepithelial bodies).

216 ed from the differentiating and delaminating endocrine cells nonautonomously regulate the flux of end

217 ring the late larval period, enterocytes and endocrine cells of a transient pupal midgut are selected

218 nalysis of ECL cells indicated that they are endocrine cells of epithelial origin that do not express

219 on of the recipients and failed to reach the endocrine cells of grafted islets.

220 ponds to sweet compounds and amino acids; in endocrine cells of gut and pancreas T1R3 contributes to

221 ns innervating the islet are also present in endocrine cells of the human islet.

222 shift toward greater understanding of other endocrine cells of the islet and their paracrine role in

223 s with MRS specifically impairs formation of endocrine cells of the pancreas head and tail.

224 tissue sample such as position of nuclei and endocrine cells of the pancreas.

225 Endocrine cells of the pancreatic islet interact with th

226 er 2 (KCC2, Slc12a5) is expressed in several endocrine cells of the pancreatic islet, including gluca

227 gests that ghrelin, a peptide synthesized by endocrine cells of the stomach and a key component of th

228 Since endocrine cells only contain a handful of these channels

229 ing of the mechanisms that govern pancreatic endocrine cell ontogeny may offer strategies for their s

230 Derived from endocrine cells, pancreatic neuroendocrine tumors (PanNE

231 This endocrine cell plasticity could have implications for is

232 Expansion of the pancreatic endocrine cell population occurs during both embryonic d

233 et al. (2018) identify in the islet core an endocrine cell population of "extreme" beta cells with d

234 delineates a major subgrouping of the islet endocrine cell populations.

235 Pancreatic islets of Langerhans consist of endocrine cells, primarily alpha, beta and delta cells,

236 n contrast, implanted, enriched polyhormonal endocrine cells principally give rise to glucagon cells.

237 We further demonstrate that endocrine cells produced in vitro do not fully eliminate

238 ort the presence of primary cilia on gastric endocrine cells producing gastrin, ghrelin, and somatost

239 , the number of neurogenin 3 (Ngn3)-positive endocrine cell progenitors is significantly reduced.

240 ogenic activity of the stem cells and in the endocrine-cell progenitors differentiating into enteroen

241 etermining gene enhancers specifies distinct endocrine-cell programs.

242 linical and biochemical characteristics, and endocrine cell proliferation and apoptosis in 150 baboon

243 lates ERK1/2 phosphorylation, did not affect endocrine cell proliferation by itself, but synergistica

244 ent of ECs and the subsequent stimulation of endocrine cell proliferation during islet development.

245 Endocrine cell proliferation fluctuates dramatically in

246 The emergence of endocrine cells requires E-cadherin downregulation, but

247 Specialized endocrine cells secrete a variety of peptide hormones al

248 Neurons, sensory cells and endocrine cells secrete neurotransmitters and hormones t

249 limentary glucose was reduced and density of endocrine cells secreting glucagon-like peptide-1 increa

250 Native antral endocrine cells share a surprising degree of transcripti

251 Endocrine cell-specific removal of Ldb1 during mouse dev

252 nown about the role of miRNA pathways during endocrine cell specification and maturation during neona

253 ver an unappreciated requirement of Hnf1b in endocrine cell specification and suggest a mechanistic e

254 The current model for endocrine cell specification in the pancreas invokes hig

255 YAP stabilisation and endocrine cell specification rely on Galphai subunits, r

256 endocrine tissue, with the full spectrum of endocrine cell subtypes not yet fully characterized.

257 known about the regeneration of the non-beta endocrine cells such as glucagon-producing alpha-cells a

258 tensities, somewhat unexpected in pancreatic endocrine cells, suggested the presence of a substantial

259 local bone environment by functioning as an endocrine cell that controls phosphate reabsorption in t

260 reveal an unknown plasticity of human adult endocrine cells that can be modulated.

261 of hES cells to stable, fully differentiated endocrine cells that exhibit physiologically regulated h

262 cultures of liver hepatocytes and pancreatic endocrine cells that have therapeutic efficacy in animal

263 ndings demonstrate an autophagy mechanism in endocrine cells that helps shape the nutritional checkpo

264 Intestinal K cells are glucose-responsive endocrine cells that might be engineered to secrete insu

265 a-cells, alpha-like poly-hormonal cells, non-endocrine cells that resemble pancreatic exocrine cells

266 mature adipocytes and preadipocytes serve as endocrine cells that secrete a number of soluble molecul

267 f many electrically excitable cells, such as endocrine cells that secrete hormones and some types of

268 Ariyachet et al. (2016) reprogrammed gastric endocrine cells to generate a renewable source of insuli

269 bility of acinar cells to change fate and of endocrine cells to reorganize in association with duct s

270 ncreases alpha cell generation, the earliest endocrine cell type to be formed in the developing pancr

271 rine progenitors, regardless of the specific endocrine cell-type chosen.

272 lt human nonendocrine pancreatic tissue into endocrine cell types by exposure to bone morphogenetic p

273 lized and differentiate into the appropriate endocrine cell types in response to physiological stress

274 sed in most beta-cells and a subset of other endocrine cell types in the pancreas.

275 astic decrease in the differentiation of all endocrine cell types owing to defects in the delaminatio

276 There are four endocrine cell types within the adult islet, including t

277 ZBTB20 is highly expressed by all the mature endocrine cell types, and to some less extent by somatol

278 c islets of Langerhans contain five distinct endocrine cell types, each producing a characteristic ho

279 Many terminally differentiated endocrine cell types, however, remain enriched for LDB1,

280 Human pancreatic islets consist of multiple endocrine cell types.

281 mal and ectodermal epithelia to generate all endocrine cell types.

282 ise to the full array of mature exocrine and endocrine cell types.

283 it is required for the specification of all endocrine cell types.

284 d to the transdifferentiation into the other endocrine cells types, indicating that this factor still

285 of the adult pancreas no longer give rise to endocrine cells under both normal conditions and in resp

286 In the mammalian pancreas, endocrine cells undergo lineage allocation upon emergenc

287 tic endoderm that differentiates into mature endocrine cells upon engraftment in mice.

288 pancreatic endoderm cells using CD142 and of endocrine cells using CD200 and CD318.

289 steroid hormone precursor cholesterol in the endocrine cells via a lipophagy mechanism.

290 islets of Langerhans remodeling and relative endocrine-cell volume in baboons.

291 ne progenitor cells from the differentiating endocrine cells, we developed a mouse model (Ngn3-Timer)

292 iduals with MRS specifically lack pancreatic endocrine cells, we micro-CT imaged a 12-week-old foetus

293 tion using selective hooks method in (neuro-)endocrine cells, we now quantify TGN budding kinetics of

294 or optimal vesicle exocytosis in neurons and endocrine cells where it functions to prime the exocytic

295 of food (fat) are sensed by antral cilia on endocrine cells, which modulates gastrin secretion and g

296 GPBAR1) is expressed by enteric neurons and endocrine cells, which regulate motility and secretion.

297 When expressed in endocrine cells, wild-type and mutant proteins were foun

298 Of note, abundant islet endocrine cells with low quantities of insulin were pres

299 iphatic amines, are reported in exocrine and endocrine cells, with insulin-producing beta cells showi

300 Regeneration of missing endocrine cells would be a significant improvement over