ライフサイエンスコーパス: endocytic

1 ven by resilient machinery that includes >70 endocytic accessory proteins (EAP).

2 ighly regulated process involves a myriad of endocytic accessory proteins (EAPs), many of which are m

3 Numerous endocytic accessory proteins collaborate with clathrin a

4 ts N-terminal domain, which in turn recruits endocytic accessory proteins.

5 re discovered: de novo protein synthesis and endocytic acidification.

6 o the plasma membrane, this myosin organizes endocytic actin networks and couples actin-generated for

7 y for propagation but also for initiation of endocytic actin networks.

8 Specifically, competition between endocytic actin patch ABPs fimbrin Fim1 and cofilin Adf1

9 explain how the ppH protocol quantifies the endocytic activity of living cells and the recruitment o

10 The epsin family of endocytic adapter proteins are widely expressed, and int

11 ribe a signaling loop whereby N-WASP and the endocytic adapter SNX18 promote lysophosphatidic acid-in

12 otrusions was distinct from labeling for the endocytic adaptor complex AP-2.

13 from our laboratory identified EHD1 (Eps15 [endocytic adaptor epidermal growth factor receptor subst

14 The TPLATE complex (TPC) is a key endocytic adaptor protein complex in plants.

15 As PLXND1 associates with GIPC family endocytic adaptors, we evaluated the requirement for the

16 regulate the import of H(+), hydrolases, and endocytic and autophagic cargos, as well as the export o

17 lichia inclusions was dependent on both host endocytic and autophagic pathways, and bacterial protein

18 pathways across both ethnicities, especially endocytic and inflammatory response pathways.

19 GTPase-activating protein likely involved in endocytic and recycling pathways.

20 labelled phospholipids, we observed that the endocytic and secretory pathways of the parasite converg

21 stering and/or degrading its targets via the endocytic and secretory pathways.

22 al syndrome of Lowe (OCRL) by coupling it to endocytic BAR domain proteins.

23 Thus, we uncover an endocytic-based mechanism able to generate TGFbeta-depen

24 ly immobile but relatively less sensitive to endocytic blockade.

25 inactivation, which releases a DAT-specific endocytic brake, and the neuronal GTPase, Rit2, which bi

26 In a recent work, we have shown that the endocytic capacity of a cell depends on its size and sur

27 ate with blood vessels, displaying very high endocytic capacity.

28 variability reflects their heterogeneity in endocytic capacity.

29 s this question, we tracked biosynthetic and endocytic cargoes after they had accumulated in PVE comp

30 for the efficient generation of these novel endocytic carriers and for their capture into the cytoso

31 and competing protein interactions can drive endocytic CCV formation and suggest new approaches to te

32 dosome maturation upstream of HOPS in highly endocytic cells (Lorincz et al., 2016a).

33 urs on Thr156 of the mu2 subunit of the main endocytic clathrin adaptor, AP2.

34 -mediated endocytosis and is undetectable in endocytic clathrin-coated pits.

35 Pharmacological blockade of LRP1 inhibited endocytic clearance of TIMP-3, leading to an increase in

36 ake the clearance of collectins by using the endocytic collagen receptor uPARAP.

37 Using endocytic colocalization and ubiquitination assays, we h

38 configurations for targeted delivery to the endocytic compartment of recipient cells.

39 llular distribution of AnxA3 in the cellular endocytic compartment suggests its involvement in modula

40 s particles' entry and residence time in the endocytic compartment were tracked during infection of M

41 lecule-A (JAM-A), triggering uptake into the endocytic compartment, where virions are proteolytically

42 causing its accumulation in a RAB4-positive endocytic compartment, which was accompanied by a defici

43 er, the endocytosed exosomes/EVs targeted to endocytic compartments exhibited a significant increase

44 Active proteasomes are detectable within endocytic compartments in mouse bone marrow-derived dend

45 required to traffic internalized dsRNA from endocytic compartments into the cytosol for innate immun

46 Many enveloped viruses infect cells within endocytic compartments.

47 cell line that lacks lysosomal hydrolases in endocytic compartments.

48 ) complex, and internalized dynamically into endocytic compartments.

49 hagy-specific complex I more active than the endocytic complex II, and the Beclin1 BARA domain.

50 l depends on its size and surface density of endocytic components (transporters).

51 phagy-dependent pathway in plants to degrade endocytic components, starting at the EPCS through the i

52 alization of the extracellular molecules via endocytic components, such as clathrin-coated pits, vacu

53 esolution of the differential recruitment of endocytic components.

54 gated whether iron availability affects TfR1 endocytic cycle and protein stability in HepG2 hepatoma

55 We delineate a parallel regulated endocytic cycle for GPCRs operating at the presynapse, s

56 Loss of this pathway, coupled with the endocytic defect inherent to aneuploidy, leads to a mark

57 Furthermore, endocytic dysfunction may be a common defect affecting t

58 y, we examined the cellular requirements for endocytic entry as well as the subcellular localization

59 Rab GTPases in HSV-1 entry and suggest that endocytic entry of HSV-1 is independent of the canonical

60 h factors which triggers the formation of an endocytic entry platform.

61 Infectious endocytic entry platforms carrying virus particles consi

62 emble, turning over multiple times during an endocytic event, similar to other actin systems.

63 The abnormal accumulation of endocytic factors observed at synapses of cultured SJ1(R

64 namin2, a PACSIN2 binding partner, and other endocytic factors were also lost from their normal local

65 e ER-endo/lysosome interface in coordinating endocytic flow with lipid transport between endocytic me

66 Recently, we determined that the endocytic function aids the turnover (i.e., protein degr

67 yeast, FUS toxicity also depends strongly on endocytic function but not on autophagy under normal con

68 , our data identify a role for Cdc48/VCP and endocytic function in regulating TDP-43 and FUS toxicity

69 FUS expression also impairs endocytic function, as previously observed with TDP-43.

70 c48 and Ubx3, a Cdc48 cofactor implicated in endocytic function, regulates the turnover and toxicity

71 matory/detoxifying gene profile, but reduced endocytic function.

72 cluster is a prerequisite for recruiting the endocytic GTPase dynamin.

73 n and r may independently contribute to the endocytic heterogeneity of a cell population.

74 ing for the first time a repurposing of this endocytic interaction mechanism during mitosis.

75 by cryo-electron tomography, contributes to endocytic internalization.

76 s on a rigid spherocylinder representing the endocytic invagination, is tightly constrained by experi

77 Exosomes are endocytic lipid-membrane bound bodies with the potential

78 Our results reveal an endocytic loop formed by circular membrane flow and ante

79 of F-actin and impairing trafficking of the endocytic LRP2 receptor, as evidenced in OcrlY/- mPTCs.

80 w here that methotrexate blocked Wnt-induced endocytic lysosomal activity and reduced canonical Wnt s

81 hrin-mediated endocytosis (CME) and its core endocytic machinery are evolutionarily conserved across

82 h substantially different affinities for the endocytic machinery come together to form a heterodimer?

83 To determine whether loss of endocytic machinery could explain defects in microvillar

84 mutations affect the nanoscale morphology of endocytic machinery has never been studied.

85 a new model where inward forces generated by endocytic machinery on the plasma membrane control the m

86 the receptor peak centers at the CS and the endocytic machinery surrounds it.

87 In LREs, we identify a conserved endocytic machinery, composed of the scavenger receptor

88 inhibitors and RNA interference of 5-HT(2)R endocytic machinery, including beta-arrestin, clathrin,

89 ptor that lacks direct interactions with the endocytic machinery.

90 e of increased affinity of the dimer for the endocytic machinery.

91 ue fibroblasts at extravascular sites via an endocytic mechanism governed by urokinase plasminogen ac

92 ma membrane exclusion depends on PAR1 and an endocytic mechanism relying on RAB5 and PI(4,5)P2.

93 croscopy is a powerful approach for studying endocytic mechanisms of cell-penetrating peptides and th

94 in Abeta accumulation via dual and opposing endocytic mechanisms of promoting Abeta production in ne

95 s microglia mediate Abeta clearance also via endocytic mechanisms.

96 pe-I myosins Myo3 and Myo5 are important for endocytic membrane reshaping, but mechanistic details of

97 gated within the endocytic pathway to couple endocytic membrane traffic to growth factor and nutrient

98 endocytic flow with lipid transport between endocytic membranes and the ER.

99 models predicted that actin filaments of the endocytic meshwork continually polymerize and disassembl

100 dual activity patterns can recruit different endocytic modes to generate new SVs and sculpt subsequen

101 at MAP1B binding to the WT Na(v)1.6 masks an endocytic motif, thus allowing long-term stability on th

102 putative canonical surface-exposed Tyr-based endocytic motifs.

103 t are produced within and secreted from late-endocytic multivesicular bodies.

104 -cell fusion assays confirmed the ability of endocytic mutants to enhance Spike-mediated fusion with

105 taneously creates a binding platform for the endocytic NECAP proteins but without significantly alter

106 ed receptor signaling and trafficking in the endocytic network.

107 the cytosol, achieved by transit through the endocytic network.

108 are important transcriptional regulators of endocytic nutrient uptake.

109 Here we investigate the impact of ER-endocytic organelle MCS on cholesterol transport.

110 Pick type C protein 1 (NPC1) in tethering ER-endocytic organelle MCS where it interacts with the ER-l

111 Tethered cytokine-containing vesicle (CytV)-endocytic organelle pairs are released sequentially.

112 Mathematical models suggest that endocytic organelle tethering could regulate the directi

113 Only endocytic organelle-tethered CytVs are preferentially tr

114 lpha(+) and IL-2(+) vesicles can tether with endocytic organelles (lysosomes/late endosomes) by formi

115 eviously unknown interorganelle tethering to endocytic organelles as a universal solution for directi

116 Modulating tethering to endocytic organelles can, therefore, coordinately contro

117 Transport of dietary cholesterol from endocytic organelles to the endoplasmic reticulum (ER) i

118 ferences in behavior between closely related endocytic organelles.

119 es of actin and actin-associated proteins in endocytic patches, we detected single-molecule residence

120 nthetic probes would aid in the study of its endocytic pathway and function.

121 es are dynamically interconverted within the endocytic pathway and how this is controlled in space an

122 This work identifies a specific endocytic pathway controlling a subset of VEGFR2 mediate

123 zes CFTR at the cell surface by limiting its endocytic pathway degradation.

124 targeting it for lysosomal degradation, this endocytic pathway functions as an amino acid supply rout

125 veal that macropinocytosis is likely a major endocytic pathway in other anthozoan species.

126 ediated AXL degradation was inhibited by the endocytic pathway inhibitors leupeptin, bafilomycin A1,

127 om amyloid precursor protein (APP) along the endocytic pathway of living cells.

128 is of extracellular fluid, the volume of the endocytic pathway remains unchanged.

129 3,4)P(2) are spatially segregated within the endocytic pathway to couple endocytic membrane traffic t

130 r that retrieve an exocytic v-SNARE from the endocytic pathway to the Golgi.

131 er) probe to gauge the redox activity of the endocytic pathway with a limitation being their inabilit

132 In the yeast endocytic pathway, cargo is sorted for recycling to the

133 Abs reduced H3N2 virus residence time in the endocytic pathway, suggesting faster virus fusion kineti

134 s suggested a general role for GBA along the endocytic pathway, we tested that hypothesis and found t

135 amyloid precursor protein (APP) through the endocytic pathway, whereas microglia mediate Abeta clear

136 ocked by inhibition of the dynamin-dependent endocytic pathway.

137 ed to systematically map cargo of the entire endocytic pathway.

138 via a combination of the secretory- and the endocytic pathway.

139 t but TAP-independent peptide loading in the endocytic pathway.

140 lexes, which have essential functions in the endocytic pathway.

141 ntly proposed to regulate trafficking in the endocytic pathway.

142 inantly mediated via the lipid raft/caveolae endocytic pathway.

143 sor that targets AXL for degradation via the endocytic pathway.

144 r route independent of the lysosome-terminal endocytic pathway.IMPORTANCE Herpes simplex virus 1 (HSV

145 oligonucleotides (ASOs) proceeds through the endocytic pathway; however, only a small fraction escape

146 penetrating peptides (CPPs), CPMPs enter the endocytic pathway; the difference is that CPMPs containi

147 be used to study cargo processing in diverse endocytic pathways and measure stage-specific activity o

148 ic between compartments of the secretory and endocytic pathways is mediated by vesicle-based carriers

149 ub where secretory, vacuolar, recycling, and endocytic pathways merge.

150 Endocytic pathways provide the primary route for therape

151 le arrays concurrently stimulate independent endocytic pathways which contribute to enhanced biomolec

152 e enzyme that traverses the biosynthetic and endocytic pathways, also affects cytoskeletal organizati

153 nd quasi-enveloped virions enter via similar endocytic pathways, but uncoat in different compartments

154 e independent of calmodulin, calcineurin and endocytic pathways.

155 ported through clathrin and dynamin mediated endocytic pathways.

156 through the negative regulation of selected endocytic pathways.

157 gulation and play key roles in secretory and endocytic pathways.

158 d actin network is sufficient to internalize endocytic pits against membrane tension.

159 eveals changes in morphology and kinetics of endocytic pits induced by disease-associated mutations i

160 The viruses were internalized in small endocytic pits that led the virus to endosomes and from

161 d to provide quantitative information on the endocytic process being studied.

162 ound in cell line TBDc1, suggesting that the endocytic process requires innate cellular components.

163 travel along microtubules, suggestive of an endocytic process.

164 mbrane protein involved in clathrin-mediated endocytic processes, and is expressed in the syncytiotro

165 rus L2 proteins, a regulation that optimizes endocytic processing and subsequent completion of the in

166 their restricted expression on immune cells, endocytic properties, and ability to modulate receptor s

167 Though endocytic protein abundance in S. pombe and S. cerevisia

168 ceptor for the degradation of Ede1-dependent endocytic protein deposits (ENDs).

169 In this pathway, the endocytic protein Ede1 functions as a selective autophag

170 The early endocytic protein Rab5 controls integrin trafficking, fo

171 Dynamin 1 is a neuronal endocytic protein that participates in vesicle formation

172 shows colocalization with clathrin, a major endocytic protein, it also colocalizes with the small GT

173 ering in platelets, nuclear pore components, endocytic proteins and microtubule networks.

174 s scarce evidence for genetic alterations of endocytic proteins as causative in high incidence human

175 gy pathway for protein condensates formed by endocytic proteins in yeast.

176 These results indicate that endocytic proteins turn over up to five times during the

177 ly from regulation of the phosphorylation of endocytic proteins, TORC2 also controls endocytosis by m

178 for an Ede1-dependent autophagy pathway for endocytic proteins, which differs from regular endocytos

179 les at the cell surface and increased the Tf endocytic rate.

180 ddition to retrograde sorting of GLUT4 after endocytic recapture, enhancing pathways for GLUT4 seques

181 binding affinities of these proteins for the endocytic receptor correlate with different turnover rat

182 We previously reported that Cubilin, the endocytic receptor for intrinsic factor-vitamin B12, alb

183 n of fibroblasts and identifies uPARAP as an endocytic receptor in immunity.

184 acrophages are dynamically controlled by the endocytic receptor LRP1.

185 docytosis and improves the expression of the endocytic receptor megalin.

186 e receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands inc

187 nctions that include its ability to regulate endocytic receptor trafficking.

188 the impact of receptor heterodimerization on endocytic recruitment is controlled by a delicate balanc

189 depends heavily on the relative strengths of endocytic recruitment of the two receptors that make up

190 Specifically, as the strength of endocytic recruitment of the weakly recruited receptor a

191 the impact of receptor heterodimerization on endocytic recruitment using a family of engineered model

192 at EIPR1 functions with EARP to control both endocytic recycling and DCV maturation.

193 et of RAB proteins involved in secretory and endocytic recycling are LRRK2 kinase substrates in vivo

194 RRK2 deregulates endolysosomal transport and endocytic recycling events.

195 lancing secretion of cell wall material with endocytic recycling of excess material incorporated into

196 d multiprotein complex that orchestrates the endocytic recycling of integral membrane proteins.

197 Endocytic recycling of internalized transmembrane protei

198 oid cells on a pathway of ubiquitin-mediated endocytic recycling of nutrient transporters.

199 3 and STAMBP activities are critical for the endocytic recycling of the GCGR.

200 or 6 (Arf6) is a small GTPase that regulates endocytic recycling processes in concert with various ef

201 s, but not the analyzed TM proteins, undergo endocytic recycling within a clearly defined subapical r

202 clathrin coat complex that has a function in endocytic recycling(4-6).

203 nctions of autophagy in synaptic plasticity, endocytic recycling, and memory.

204 esponds to the pH changes encountered during endocytic recycling, suggesting APOL1 forms a cytotoxic

205 n addition to advancing the understanding of endocytic recycling, we uncover a fundamentally differen

206 gy is inhibited during NMDAR-LTD to decrease endocytic recycling.

207 Here, we identify a novel role of the endocytic regulator EHD1 and a potential EHD1 partner, R

208 Monensin-sensitive 1 (Mon1) is an endocytic regulator that participates in the conversion

209 This unconventional endocytic regulatory mechanism aimed at reducing surface

210 to low zinc concentrations in a zinc-induced endocytic response of mouse ZIP4 (mZIP4).

211 ne stress causes swelling of the cell and an endocytic response, which together increase membrane ten

212 The endocytic retrieval of NHE3 was promoted by depletion of

213 vesicle fusion at defined release sites and endocytic retrieval of synaptic vesicle membranes.

214 A nontraditional endocytic route may be employed, such as one that inters

215 The subversion of endocytic routes leads to malignant transformation and h

216 zes, the collective actions of these various endocytic routes should also vary based on the cell size

217 However, internalization, choice of endocytic routes, and degradation of the D2R in lysosome

218 Among the endocytic routes, macropinocytosis has unique characteri

219 quality control cue at the cell surface for endocytic routing to lysosomes.

220 ng nexin 9 (SNX9), a central multifunctional endocytic scaffold protein.

221 Vacuoles receive material via the endocytic, secretory, and autophagic pathways.

222 secreted, demonstrating the operation of an endocytic-secretory cycle.

223 We identify a '4Y' endocytic signal in ZNRF3, which PTPRK maintains unphosp

224 ding phagosome maturation, clathrin-mediated endocytic signaling and redox balance.

225 Dip1 can initiate branched actin networks at endocytic sites without disrupting their branched archit

226 p1 are required for proper actin assembly at endocytic sites, but how they coordinately control Arp2/

227 is (CME) by recruiting cargo and clathrin to endocytic sites.

228 Abscission requires the endocytic sorting complex required for transport (ESCRT)

229 nternalization and desensitization, and post-endocytic sorting, as well as region-specific expression

230 ates diverse processes, including autophagy, endocytic sorting, phagocytosis, anabolic responses and

231 ts at well-conserved and physically distinct endocytic stations.

232 r compete with heterodimers for space within endocytic structures.

233 poration of the weakly recruited receptor to endocytic structures.

234 DS, lysosomal degradation of autophagic and endocytic substrates is selectively impaired, causing th

235 ic activities and turnover of autophagic and endocytic substrates, processes vital to neuronal surviv

236 esearch that implicate apolipoprotein E, the endocytic system, cholesterol metabolism and microglial

237 itides, markers of organelle identity in the endocytic system.

238 1/Pan1 and AtEH2/Pan1) are components of the endocytic TPLATE complex (TPC) which is essential for en

239 fied both known and novel interactors of the endocytic TPLATE complex.

240 A portion of the endocytic tracer FM4-64 is also recycled back to the PM

241 e fluorophore for ratiometry, and acts as an endocytic tracer.

242 Furthermore, endocytic traffic and brefeldin A body formation are per

243 We examined the effect of deleting OCRL on endocytic traffic and cell division in newly created hum

244 resses tumor proliferation by regulating the endocytic trafficking and degradation of the EGFR and tr

245 ort hub in the cell, with a critical role in endocytic trafficking and endoplasmic reticulum (ER) to

246 By targeting endocytic trafficking and retromer recycling to the plas

247 nd metastatic activity, including changes in endocytic trafficking and signaling of cell surface rece

248 hts into the molecular mechanism of Fas post-endocytic trafficking and signalling, opening possible e

249 osome, where they might function to regulate endocytic trafficking and/or the formation or recycling

250 nts defective in modulating membrane protein endocytic trafficking are incapable of antagonizing TIM-

251 ls, including the regulation of signaling by endocytic trafficking as well as the application of conc

252 downstream of RTKs can reciprocally regulate endocytic trafficking by creating feedback loops in cell

253 se NRP1 splice variants in the regulation of endocytic trafficking for cancer cell dissemination.

254 propose that caspase-mediated regulation of endocytic trafficking is an evolutionarily conserved fun

255 downstream of the Hippo Network to regulate endocytic trafficking of at least four cell polarity, ce

256 l, we identified EHDs as novel regulators of endocytic trafficking of Cx43, participating in the path

257 While postactivation endocytic trafficking of EGFR has been well elucidated,

258 and-common to sphingolipid diseases-abnormal endocytic trafficking of lactosylceramide.

259 ce of multiple protein families required for endocytic trafficking of the C. burnetii-containing vacu

260 This increased endocytic trafficking of the two NRP1 variants, upon HGF

261 suggest that GBA is critically important for endocytic trafficking of viruses as well as of cellular

262 nhibiting GCGR internalization or disrupting endocytic trafficking prevented agonist-induced deubiqui

263 Glucagon stimulation not only promoted GCGR endocytic trafficking through Rab5a early endosomes and

264 Endocytic trafficking to the vacuole positively regulate

265 These findings suggest that endocytic trafficking to the vacuole regulated by the en

266 essential for the LR organogenesis driven by endocytic trafficking to the vacuole.

267 ta2 induced both LR primordium formation and endocytic trafficking toward the vacuole.

268 ace availability is dynamically regulated by endocytic trafficking, and direct protein kinase C (PKC)

269 l in late endosomes/lysosomes, disruption of endocytic trafficking, and stalled autophagic flux.

270 ision, requires well-orchestrated changes in endocytic trafficking, microtubule severing, actin clear

271 gs help clarify our current understanding of endocytic trafficking, providing significant additional

272 Our study provides insights into endocytic trafficking-mediated mechanisms for spatiotemp

273 tigate the pathways and signals required for endocytic trafficking.

274 echanism by which the Hippo Network controls endocytic trafficking.

275 mplicate CRACR2a-dynein in calcium-regulated endocytic trafficking.

276 omponent being essential to ensure efficient endocytic transport of incoming viral genomes.

277 One example involves rapid endocytic turnover of Mup1, a yeast methionine transport

278 While tetherin can mediate virus endocytic uptake and clearance, this has not been observ

279 Our data suggest that this endocytic uptake can be mediated by tetherin itself or b

280 This work, which utilizes the difference in endocytic uptake of enzymatically formed peptide assembl

281 result, multiple strategies have focused on endocytic uptake of proteins.

282 We explored how altered endocytic uptake, water reabsorption, SNGFR and glomerul

283 cles for cell expansion and counterbalancing endocytic uptake.

284 f the siRNA payload by escaping or bypassing endocytic uptake.

285 imary cationic osmolyte internalized, exited endocytic vacuoles via two-pore channels, accompanied by

286 mune receptors that couple ligand binding to endocytic vesicle damage to permit MHC class I antigen p

287 DNM2) is a GTP-binding protein that controls endocytic vesicle scission and defines a whole class of

288 These assays revealed that when endocytic vesicle scission fails, tubules are pulled int

289 up to five times during the formation of an endocytic vesicle, and suggest revising quantitative mod

290 , one can detect the formation of individual endocytic vesicles (EVs) with an unmatched temporal reso

291 nd that 74% of rOATP1A4-containing rat liver endocytic vesicles (n = 12,044) also contained rOATP1A1.

292 Macropinosomes are distinct from endocytic vesicles and autophagosomes in that they are s

293 ing images of nucleoporins, TORC1 complexes, endocytic vesicles and Bax pores.

294 PDZK1 associates with rOATP1A1-containing endocytic vesicles within cells, mediating recruitment o

295 e cells, repair neurons, promote scission of endocytic vesicles, and seal phagosomes.

296 istinguish axially close-by membranes, early endocytic vesicles, or tubular membrane structures.

297 mbrane but plays a unique role in collecting endocytic vesicles, sorting of internalised cargos and d

298 ed CCV size due to impaired fusion with late endocytic vesicles.

299 hrin-mediated endocytosis by positioning the endocytic zone at the postsynaptic density, independentl

300 ne-related with exocytosis-as well as at the endocytic zone-periactive zone.