ライフサイエンスコーパス: endometrium

1 ries, pancreas, stomach, uterus, cervix, and endometrium).

2 c features of tissue renewal and a receptive endometrium.

3 d to abrogation of AKT activation within the endometrium.

4 ificant for clear cell adenocarcinoma of the endometrium.

5 ions compared with the peritoneum or eutopic endometrium.

6 d-type females and exhibited a thick uterine endometrium.

7 ult in detectable DNA damage or apoptosis in endometrium.

8 ved in the higher EDA exon inclusion rate in endometrium.

9 B during the cyclic development of the human endometrium.

10 tients with endometriosis compared to normal endometrium.

11 id1a and/or Pten conditional deletion in the endometrium.

12 ons in hormonal milieu similar to the native endometrium.

13 in latent precancers of normal premenopausal endometrium.

14 endometrial cancer, matched blood and normal endometrium.

15 greater degree in the ectocervix than in the endometrium.

16 nce that VEGF has pleiotropic effects in the endometrium.

17 ded upon its first contact with the maternal endometrium.

18 e pro-estrogenic effects of tamoxifen on the endometrium.

19 carcinoma of the breast, prostate, colon and endometrium.

20 trioid endometrial cancer compared to normal endometrium.

21 which may be relevant to pathologies of the endometrium.

22 nd therefore do not implant into the uterine endometrium.

23 tome was indistinguishable from luteal phase endometrium.

24 ltrastructural hallmark of the postovulation endometrium.

25 ation of epithelial and stromal cells in the endometrium.

26 e not a prominent feature of the nonpregnant endometrium.

27 yonic activities with the developing uterine endometrium.

28 ficient detoxification of tamoxifen in human endometrium.

29 m the recruitment of blood NK cells into the endometrium.

30 d in endometrial tumors compared with normal endometrium.

31 ng W21, C98, and V102 are expressed in sheep endometrium.

32 on in neoplasms originating from the uterine endometrium.

33 urce of cells that differentiate to form the endometrium.

34 ng the physiology and pathology of the human endometrium.

35 Incident invasive cancer of the ovary and endometrium.

36 with FOXA2 binding intervals in the P and MS endometrium.

37 ausative role in malignant transformation of endometrium.

38 l hyperplasia compared with normal secretory endometrium.

39 seven patients with benign neoplasia of the endometrium.

40 eases in stromal cell Ang-1 in LTPOC-exposed endometrium.

41 eus in PE, and only nuclear in the secretory endometrium.

42 ar hyperplasia (n = 25) compared with normal endometrium.

43 CR showed that Lactobacillus was rare in the endometrium.

44 ostic marker for patients with cancer of the endometrium.

45 g site motifs, were detected in the P and MS endometrium.

46 ssion in proliferative (estrogen-stimulated) endometrium.

47 ogenesis and endothelial repair in the human endometrium.

48 menopausal endometrium than in premenopausal endometrium.

49 ers, one for normal and the other pathologic endometrium.

50 o caruncular or intercaruncular areas of the endometrium.

51 part of the uterus (the body) containing the endometrium.

52 re to define the FOXA2 cistrome in the human endometrium.

53 sively colonize the epithelial lining of the endometrium.

54 embryonic tissues and genes expressed in the endometrium.

55 rkhead box A2 (FOXA2) cistrome for the human endometrium.

56 changes in proliferative and secretory phase endometrium.

57 caruncular and intercaruncular areas of the endometrium.

58 riate for detecting bacteria adherent to the endometrium.

59 the underlying stroma to firmly embed in the endometrium.

60 ed in part to a foreign body reaction in the endometrium.

61 r to evaluate the receptive functions of the endometrium.

62 as well as lack of secretory changes in the endometrium.

63 generate a 3D rendering of the cycling human endometrium.

64 (1.32, 1.24-1.40), breast (1.17, 1.15-1.19), endometrium (1.19, 1.13-1.24), ovary (1.17, 1.11-1.23),

65 tmenopausal (27.3) compared to premenopausal endometrium (4.9) mainly as a result of lower ER-beta ex

66 lpha in 4 archived human specimens of normal endometrium; 7 endometrial hyperplasia with or without a

67 e than 90%; cervix, 40% and 70%-80%; uterus (endometrium), 80% and more than 90%; bladder, 30% and 50

68 , and ultrasonography revealed a 10 mm thick endometrium, a poorly visualised left ovary, and a 2 cm

69 tissue-adherent bacteria compared to that in endometrium absent of biofilm.

70 road map connecting the blastocyst with the endometrium across species is diverse (1) and not fully

71 Here, we show that loss of Pten in the mouse endometrium activates Akt and results in increased phosp

72 The uterine endometrium adopts multiple physiological states over a

73 The hyperproliferation of the endometrium affected both implantation and maintenance o

74 Regeneration of the endometrium after menstruation requires a rapid and high

75 rains of fibroblasts from the myometrium and endometrium also demonstrated heterogeneous Thy 1 expres

76 oblast and extracellular matrix (ECM) in the endometrium anchors the embryo to the uterine wall.

77 n requires communication between a receptive endometrium and a healthy blastocyst.

78 BP-1) is a secretory product of decidualized endometrium and a major constituent of amniotic fluid.

79 sets of sex-steroid-related tumors including endometrium and breast carcinomas that are associated wi

80 The bacterial profiles of the endometrium and cervix were dominated by Acinetobacter,

81 luid, PrP-Sc was detected only in caruncular endometrium and cotyledonary chorioallantois of pregnant

82 eable population of uILC3s is found in human endometrium and decidua, which are mostly NCR(+) and par

83 An unreceptive endometrium and disrupted maternal-conceptus interaction

84 cin 1 (PROK1), is expressed in the receptive endometrium and during early pregnancy.

85 opian tube and cervical tissues, followed by endometrium and ectocervix.

86 Here, we show that both normal human endometrium and endometrial cancers express the receptor

87 erone-resistant molecular environment of the endometrium and endometriosis lesions; and (v) restores

88 r transgene expression specifically in mouse endometrium and found that endometrial-specific VEGF ove

89 ve been noted in cancers of the prostate and endometrium and in glioblastoma multiforme, among many o

90 hows is transcribed in normal and neoplastic endometrium and in MCF-7 cells, forms a stable RNA quadr

91 ntral target for growth regulation of normal endometrium and in the pathogenesis of ECA.

92 ight was accompanied by proliferation of the endometrium and induction of progesterone receptor (PgR)

93 oliferative (P)- and midsecretory (MS)-phase endometrium and integrated with the transcriptome determ

94 ic cells and luminal epithelial cells of the endometrium and is implicated in the initial attachment

95 ial carcinoma compared with levels in normal endometrium and low-grade tumors.

96 miological feature of cancers of the breast, endometrium and ovary is the sharp slowing down in their

97 Akt1 deficiency had a profound effect on endometrium and prostate neoplasia, two types of human c

98 rds the mouse embryo by invading the uterine endometrium and remodelling the maternal vasculature.

99 e conducive to HIV-1 replication than is the endometrium and that IL-6 enhances HIV-1 transcription a

100 tant role in the malignant transformation of endometrium and that Lkb1 loss promotes a highly invasiv

101 bserved expression of several Siglecs on the endometrium and that these receptors interact with sialy

102 logue between the hormonally primed maternal endometrium and the free-floating blastocyst.

103 eepithelialization in both the postmenstrual endometrium and the mouse uterus after decidual breakdow

104 been shown to be induced by tamoxifen in the endometrium and to be a growth factor for endometrial en

105 The endometrium and uterus also arise from the coelomic epit

106 factor 1 (SRSF1) is more highly expressed in endometrium and, using RNA interference, that it is invo

107 pausal endometrium, reduced in premenopausal endometrium, and absent or reduced in a majority of prim

108 plants, high DWI signal greater than that in endometrium, and ADC less than or equal to 0.905 x 10(-3

109 tecture and cellular morphology of the mouse endometrium, and allows for the recovery of high-quality

110 blastocyst interacts with and regulates the endometrium, and endometrial fluid secreted by the endom

111 n in normal human tissues, including cycling endometrium, and in breast carcinomas, tissues in which

112 ncers in the oesophagus, colorectum, breast, endometrium, and kidney.

113 on-weighted imaging signal with reference to endometrium, and low apparent diffusion coefficient enab

114 than one primary cancer of the colorectum or endometrium, and mean age of presentation) and performs

115 dent cancers, including those of the breast, endometrium, and ovary.

116 pathway regulates innate immunity within the endometrium, and that isoprenoids are regulatory molecul

117 sed expression of Cyr61 compared with normal endometrium, and this lowered expression may provide the

118 e interactions between the conceptus and the endometrium are coordinated at the level of an individua

119 entation, but their functions in nonpregnant endometrium are not understood.

120 IL-15 levels in normal endometrium are progesterone-responsive.

121 ptional and proteomic changes in the uterine endometrium are required to facilitate receptivity to an

122 Immune cells in the endometrium are targeted by HIV and re-programmed to all

123 d into endometriotic lesions but not eutopic endometrium, as revealed by flow cytometry and immunohis

124 etected only in the epithelia of the uterine endometrium, as well as epithelia of the oviduct, cervix

125 Interactions between embryo and endometrium at implantation are critical for the progres

126 mRNA of IL-22R1 was detected in pregnant endometrium at levels similar to other equine epithelia.

127 d the transcriptomic transformation of human endometrium at single-cell resolution across the menstru

128 osphorylation and activation of Stat3 in the endometrium before implantation.

129 ) in the number of inflammatory cells in the endometrium between areas with and without tissue-adhere

130 , or metastatic cancer of the ovary, cervix, endometrium, bladder, prostate, oesophagus, squamous cel

131 d in endometrial cancer compared with normal endometrium but the underlying mechanisms are not well u

132 ecules, executed by either the embryo or the endometrium, but initiated by signals coming from the em

133 clic differentiation and apoptosis in normal endometrium, but its role in endometrial carcinogenesis

134 rentially targets memory CD4+ T cells in the endometrium, but these cells exhibit unique phenotypes a

135 , differentiation, and carcinogenesis in the endometrium by controlling gene transcription.

136 plasmid-free C. muridarum directly into the endometrium by intrauterine inoculation.

137 Colonization of the endometrium by pathogenic bacteria ascending from the lo

138 t PAPPA is essential to maintain a receptive endometrium by up-regulating N-fucosylation, which is a

139 ages present in the peritoneum and in menses endometrium can contribute to the inflammatory microenvi

140 vide insight into the mechanism by which the endometrium can escape the plethora of growth regulatory

141 We compare dermis and endometrium capacities to support trophoblast invasion,

142 uman cancers of the prostate, breast, ovary, endometrium, cervix, and bladder, and a region of deleti

143 o 6 was observed in fallopian tubes, uterine endometrium, cervix, and ectocervix.

144 Interestingly, increased apoptosis in human endometrium coincides with the implantation window.

145 lignancies, including cancers of the breast, endometrium, colon, and prostate.

146 ast cells and fibronectin as invasion of the endometrium commences.

147 eveal an increase of SIRT1 expression in the endometrium compared to control mice.

148 ioallantois, allantoic fluid, and caruncular endometrium contained higher levels of PrP-C than did in

149 The uterine endometrium coordinates a wide spectrum of physiologic a

150 could affect the angiogenic potential of the endometrium, creating a feed forward loop resulting in m

151 pared to more relevant host human epithelial endometrium-derived HEC-1B and cervix-derived HeLa cells

152 reproductive biology could also be played by endometrium-derived viral particles that influence devel

153 Bacterial profiles of the endometrium differed from those of the oral cavity, rect

154 enocopy murine CD122+Macs in secretory phase endometrium during the implantation window and in first-

155 we report on the composition of uILCs in the endometrium during the luteal phase and in the decidua d

156 account for the increased NK cell numbers in endometrium during the menstrual cycle.

157 The human endometrium (EM) contains macrophages, NK cells, T cells

158 ry epithelial cells and fibroblasts from the endometrium (EM), endocervix (CX) and ectocervix (ECX) s

159 genes expressed in extraembryonic tissue and endometrium emphasize a coordinated communication betwee

160 Ex vivo organ cultures of endometrium, endometrial cells and peripheral blood mono

161 carcinomas arising from the bladder, cervix, endometrium, esophagus, gallbladder, kidney, liver, and

162 neoplasms, such as those in the thyroid and endometrium, exhibit more than one pattern of differenti

163 Our data reveal that endometrium expresses a higher rate of the fibronectin (

164 on in the upper tissues (fallopian tubes and endometrium), followed by cervix and ectocervix.

165 (PR) and its coregulators prepares the human endometrium for receptivity to embryo implantation and m

166 Using endometrium from 2 different donors, EEO were derived an

167 d to matched eutopic patient samples as well endometrium from healthy controls.

168 ed significantly increased staining in human endometrium from late secretory and menstrual phases.

169 eacetylase and gene silencer, in the eutopic endometrium from women with endometriosis throughout the

170 ic endometriotic lesions and matched eutopic endometrium from women with endometriosis.

171 cancer cells, including breast, lung, ovary, endometrium, gastric, and melanoma, which could be rescu

172 In eutopic endometrium, GLI1 expression is reduced in women with en

173 Recent molecular studies concluded that the endometrium has a resident microbiota dominated by Lacto

174 Endometrium has its characteristic DNA methylation profi

175 Previous transcriptome studies of the human endometrium have revealed hundreds of simultaneously up-

176 cer showed increased risk for cancers of the endometrium (HR, 1.76; 95% CI, 1.34-2.31), breast (HR, 1

177 ks (AH v SH, CH, or disordered proliferative endometrium [ie, equivocal EH]) from the case-control an

178 ive neurons, the cervix, the vagina, and the endometrium in 5- to 400-fold higher numbers when cultur

179 chemokines CXCL10 and/or CXCL11 within human endometrium in 85% of patient samples tested.

180 e, the first study to compare ectocervix and endometrium in a tissue explant model of HIV-1 infection

181 Regeneration of the endometrium in each menstrual cycle is required for repr

182 ler (uNK) cells are abundant in decidualized endometrium in early pregnancy; they surround spiral art

183 itro, as well as N-fucosylation level of the endometrium in pregnant mice.

184 esignated as SERPINA14, are expressed in the endometrium in response to progesterone.

185 responses and also is upregulated within the endometrium in response to the developing embryo during

186 ed electrogenic glucose transport across the endometrium in wild type (Slc5a1 (+/+)) but not in SGLT1

187 kidney, pancreas, esophageal adenocarcinoma, endometrium) in CRC survivors, and compared associations

188 es the neoplastic effect of Pten loss in the endometrium, in contrast to complete estrogen depletion.

189 d with increased expression in the quiescent endometrium, indicate that this homeodomain gene is invo

190 ight support a role for enJSRVs in conceptus-endometrium interactions during the peri-implantation pe

191 rtment, deregulated SGK1 activity in cycling endometrium interferes with embryo implantation, leading

192 e C57BL/6 mice by implantation of autologous endometrium into the peritoneal cavity.

193 The endometrium is a complex, steroid-dependent tissue that

194 Human endometrium is a high dynamic tissue that contains endom

195 ing of the mechanisms of angiogenesis in the endometrium is a major limitation for use of antiangioge

196 Under the hypothesis that gene expression in endometrium is dependent on gene expression of extraembr

197 rate that hCG-mediated LIF expression in the endometrium is dependent on prior induction of PROK1.

198 Human trophoblast invasion of decidualized endometrium is essential for placentation and is tightly

199 lish whether activation of Stat3 in maternal endometrium is essential for successful implantation.

200 The human endometrium is essential in providing the site for impla

201 Undesirable stimulation of the breast and endometrium is not apparent.

202 TGFbeta signaling through TGFBR1/ALK5 in the endometrium is required for endometrial homeostasis, tum

203 In women, much of the endometrium is shed and regenerated each month during th

204 Endometrium is the inner lining of the uterus which is c

205 The inner uterine lining (endometrium) is a unique tissue going through remarkable

206 sion, if there is a microbiota in the middle endometrium, it is not dominated by Lactobacillus as was

207 f the colon, female breast (postmenopausal), endometrium, kidney (renal cell), and esophagus (adenoca

208 as those originating in ovary, lung, breast, endometrium, kidney, and brain.

209 diverse human tumours including breast, CNS, endometrium, kidney, liver, lung, lymphoid, oesophagus,

210 The Laparoscopic Approach to Cancer of the Endometrium (LACE) trial was a multinational, randomized

211 es such as PTEN within histologically normal endometrium (latent precancers) is an early step in endo

212 lamydia trachomatis may ascend to infect the endometrium, leading to pelvic inflammatory disease.

213 It is defined by the presence of endometrium-like tissue (lesions) outside the uterus, mo

214 hanges the regulation of angiogenesis in the endometrium, likely by reducing angiogenic activity.

215 tragonadal tissues including bone, placenta, endometrium, liver, and blood vessels from a number of m

216 poplasia characterized by loss of the entire endometrium (luminal and glandular epithelium and stroma

217 lso significant in carcinomas of the kidney, endometrium, lung, breast, bladder, and pancreas.

218 ere also observed for cancers of the breast, endometrium, lung, kidney, upper aerodigestive tract, li

219 found that the epithelial compartment of the endometrium maintains its epithelial identity during the

220 demonstrate that the high FN content of the endometrium matrix, and not specifically the EDA domain,

221 n cells that support the survival of ectopic endometrium may be an effective therapeutic approach in

222 her levels of PrP-C than did intercaruncular endometrium, myometrium, oviduct, ovary, fetal bladder,

223 d significant excess risks of cancers of the endometrium (n = 11; observed rate, 16.1/10,000 person-y

224 arker of eosinophil degranulation) in normal endometrium (n = 20) and endometriosis samples (n = 24)

225 tissue (n = 229) and caruncular areas of the endometrium (n = 218, r > 0.9999, eFDR < 0.001) revealed

226 eding that of background DNA controls in the endometrium of 60% (15/25) of the study subjects.

227 e system, and intrinsic abnormalities in the endometrium of affected women and secreted products of e

228 antly higher levels of IL-33 compared to the endometrium of healthy, fertile controls.

229 nstrated phosphorylation of STAT3 in eutopic endometrium of infertile women with this disorder leadin

230 e detected previously TAM-DNA adducts in the endometrium of women receiving TAM (Shibutani et al., Ca

231 luminal epithelium, but downregulated in the endometrium of women suffering from RPL.

232 NA adducts are mutagenic and detected in the endometrium of women treated with TAM, TAM adducts are s

233 of K-ras mutations has been observed in the endometrium of women treated with TAM.

234 ertheless this population is resident in the endometrium of women who have RM, more than three months

235 6 are coordinately over-expressed in eutopic endometrium of women with endometriosis and likely parti

236 FOXA2 is also reduced in the endometrium of women with endometriosis in correlation w

237 aimed to identify the most stable HKG in the endometrium of women with recurrent implantation failure

238 nto layers (myometrium, junctional zone, and endometrium) of uterine remnants.

239 s characterized by the growth of the uterine endometrium on the surface of organs within the pelvic r

240 Uterine amyloid accumulated in the endometrium, only at the site of placental attachment, c

241 s, transmit EHV1 to endothelial cells of the endometrium or central nervous system, causing reproduct

242 an intermediate DWI signal less than that in endometrium or lymph nodes allowed readers to confidentl

243 from the human oral cavity, amniotic fluid, endometrium, or vagina (including women with bacterial v

244 for carcinomas of the anus, bladder, cervix, endometrium, ovary, penis, prostate, rectum, testis, vag

245 iking reduction of uNK in asoprisnil-treated endometrium (p < 0.001).

246 gnaling between the cloned conceptus and the endometrium, particularly the intercaruncular tissue.

247 lial cells derived from normal proliferative endometrium (PE; n = 10) were dose-dependently and maxim

248 y on estrogenic stimulation of the breast or endometrium) precludes recommending long-term use.

249 d (stomach, biliary tract, pancreas, cervix, endometrium, prostate, kidney, bladder, and lymphoma) th

250 sylation of integrin alphaVbeta3, a critical endometrium receptivity biomarker, was up-regulated by P

251 itioned medium of trophoblast cells promoted endometrium receptivity in vitro.

252 However, the relationship between PAPPA and endometrium receptivity, as well as the regulation of N-

253 EMX2OS are abundant in normal postmenopausal endometrium, reduced in premenopausal endometrium, and a

254 atin remodeling gene, are prevalent in human endometrium-related malignancies.

255 e the exact localization of Ang in the human endometrium remains a subject of controversy, we have ad

256 oexpressed between extraembryonic tissue and endometrium revealed significantly enriched modules with

257 ced by the chorionic girdle binds IL-22R1 on endometrium, serving as a mechanism of fetal-maternal co

258 Endothelial cell proliferation analysis in endometrium showed a peak during the late menstrual and

259 In situ staining of human myometrium and endometrium showed heterogeneous staining for Thy 1.

260 fen acts as an agonist in the postmenopausal endometrium, similar to estrogen in the breast, we compa

261 cancers of the liver, pancreas, gallbladder, endometrium, stomach, kidney, brain (benign), brain (mal

262 type II (Lynch II) with tumors found in the endometrium, stomach, ovary, and upper urinary tract in

263 Proliferative diseases of the endometrium such as endometriosis and cancer are common

264 gen-A11 (MAGE-11) in the mid-secretory human endometrium suggested a novel function in human PR signa

265 T1, 1,514 msec +/- 156; T2, 79 msec +/- 10), endometrium (T1, 1,453 msec +/- 123; T2, 59 msec +/- 1),

266 as more abundant in quiescent postmenopausal endometrium than in premenopausal endometrium.

267 uce specific chemokines in nonpregnant human endometrium that can activate NK cell migration, and sug

268 ion of localized VEGF secretion in the human endometrium that may be necessary for the successful est

269 Substituting endometrium, the natural trophoblast target, with dermis

270 ugh VEGF expression has been detected in the endometrium, the relationship between VEGF production, r

271 In asoprisnil-treated endometrium, there is a marked downregulation of stromal

272 ctivity by receptor phosphorylation in human endometrium throughout the menstrual cycle.

273 es, 60 endometrial cancer tissues, 10 normal endometrium tissues from normal healthy controls, and 32

274 ability of the extraembryonic tissue and the endometrium to develop a fine-tuned adaptive response ch

275 NF subunit mutations in the translocation of endometrium to distal sites, with loss of cell integrity

276 a critical regulator of the response of the endometrium to E2 in regulating tissue homeostasis.

277 Excessive and prolonged exposure of the endometrium to estrogens unopposed by progesterone and a

278 ells of the equine placenta migrate into the endometrium to form endometrial cups, dense accumulation

279 to regulate the proinflammatory response of endometrium to IL1B2 during conceptus elongation and att

280 nvade and reorganize vessels of the maternal endometrium to initiate blood flow to the intervillous s

281 Progesterone regulates the endometrium to support pregnancy establishment and maint

282 methylation of GJA1 and related genes in the endometrium, triggering long-term silencing of these loc

283 The human endometrium undergoes regular cycles of synchronous tiss

284 In a human menstrual cycle the endometrium undergoes remodeling, shedding and regenerat

285 ality in patients with adenocarcinoma of the endometrium (ungrouped P = 0.034).

286 have shown that estrogen largely acts on the endometrium via estrogen receptor ERalpha, we generated

287 dia, we introduced C. trachomatis into mouse endometrium via transcervical inoculation and compared t

288 In addition, endometrium was profiled to identify the communication p

289 and PTEN expression in an individual normal endometrium was seen in 21% of patients, but usually inv

290 sues are dependent of genes expressed in the endometrium, we performed an integrative analysis of tra

291 xpression in normal pre- and post-menopausal endometrium, well-differentiated endometrial adenocarcin

292 SAA3 mRNA levels in the uterine endometrium were as high as SAA2 in the liver, yet mass

293 Samples from the endometrium were collected for cytology, histopathology,

294 ring a Hand2 knock-out specifically in their endometrium were shown to develop precancerous endometri

295 can be relatively large and have functioning endometrium, which can be associated with pain.

296 t heavy menstrual bleeding by destroying the endometrium, which is responsible for heavy periods.

297 ms by which the trophoblast cells invade the endometrium while evading maternal immune destruction ar

298 rain, pancreas, liver, lung, heart, gut, and endometrium, with a mixer chamber for systemic circulati

299 s markedly in proliferative versus secretory endometrium, with high expression in proliferative (estr

300 Emx2, and Emx2os are abundant in the uterine endometrium, with sense and antisense transcripts exhibi