ライフサイエンスコーパス: endonuclease

1 op-induced ATR activation requires the MUS81 endonuclease.

2 throughout the genome by the conserved Spo11 endonuclease.

3 tly stimulates DNA cleavage by the MutLgamma endonuclease.

4 -3' exonuclease and secondarily as a 5'-flap endonuclease.

5 hierarchy of sRNA features recognized by the endonuclease.

6 thereby establishing SLFN11 as a novel tRNA endonuclease.

7 critical acidic residues of TerL(lambda) 's endonuclease.

8 used as overlapping genes with a stand-alone endonuclease.

9 ndency of Cas9 to develop a XNA-programmable endonuclease.

10 RFC are sufficient to activate the MutLgamma endonuclease.

11 ates DNA incision by the cognate restriction endonuclease.

12 atically escaped degradation from all tested endonucleases.

13 stently escaping degradation from all tested endonucleases.

14 yotes, where they function as RNA-guided RNA endonucleases.

15 rting modification dependent activity of the endonucleases.

16 lated in cells expressing any of these viral endonucleases.

17 milar to the RuvC family of the RNase H-like endonucleases.

18 of AgeI is novel among Type IIP restriction endonucleases.

19 es, a central role for apurinic/apyrimidinic endonuclease 1 (APE1) has been demonstrated.

20 Within BER, AP-endonuclease 1 (APE1) is a multifunctional enzyme that p

21 Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repa

22 This presents AP to apurinic/apyrimidinic endonuclease 1 (APE1) that poorly cleaves the AP backbon

23 s less efficiently incised by recombinant AP endonuclease 1 (APE1) when the DNA backbone is facing th

24 drogenase (GAPDH) with apurinic/apyrimidinic endonuclease 1 (Ape1), the major oxidized DNA repair enz

25 d bases and stimulated apurinic/apyrimidinic endonuclease 1 (APE1)-mediated DNA incision.

26 glycosylase (UDG) and apurinic/apyrimidinic endonuclease 1 (APE1).

27 zymes DNA polymerase delta (Pol delta), flap endonuclease 1 (FEN1) and DNA ligase I (LigI) that compl

28 Human flap endonuclease 1 (FEN1) and related structure-specific 5'n

29 This stimulated flap endonuclease 1 (FEN1) cleavage of TNRs engaged in an R-l

30 Here, we characterized a flap endonuclease 1 (FEN1) plus hairpin DNA probe (hpDNA) sys

31 the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments f

32 Here we show RAD27/FEN1, which encodes flap endonuclease 1 (FEN1), a structure-specific nuclease wit

33 other mutant screening methods including T7 endonuclease 1 (T7E1), CRISPR/Cas-derived RNA-guided eng

34 factor C complex, DNA polymerase delta, flap endonuclease 1 and DNA ligase 1.

35 We found that AP endonuclease 1 incised an abasic site on the nontemplate

36 on RNA and that human apurinic/apyrimidinic endonuclease 1 incises RNA abasic sites in RNA-DNA hybri

37 Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome

38 donuclease activity of apurinic/apyrimidinic endonuclease 1 is required for the processing of miR-221

39 ssDNA-dependent ATPase, ssDNA binding, ssDNA endonuclease, 5' to 3' ssDNA translocase and 5' to 3' he

40 al enzyme composed of an N-terminal DNA flap endonuclease/5' exonuclease domain (FEN/EXO) and a C-ter

41 The total number of predicted endonucleases across the 20 NCLDV was nearly quadrupled

42 e related to APE1, the apurinic/apyrimidinic endonuclease acting in base excision repair.

43 aling by Sae2 is mostly independent of Mre11 endonuclease activation but requires Mec1 and Tel1-depen

44 Zip2:Spo16 lacks an endonuclease active site, but binds specific DNA structu

45 This model explains how both exonuclease and endonuclease activities of Mre11 functionally integrate

46 s, we show that the combined exonuclease and endonuclease activities of recombinant MRX-Sae2 preferen

47 double-strand breaks and has exonuclease and endonuclease activities that help to initiate the repair

48 cid detection by spatiotemporally modulating endonuclease activities.

49 n a double-flap substrate, which prevents AP endonuclease activity and endonuclease-induced double-st

50 RNase J2, on the other hand, has endonuclease activity and one metal ion at the active si

51 os that are consistent with the data: either endonuclease activity and subsequent error-prone repair

52 all DNA guides depends on both its intrinsic endonuclease activity and the cellular double-strand bre

53 BRCA2-deficient cells require the apurinic endonuclease activity and the PCNA-binding domain of Ape

54 The I38T/F/M substitutions impaired PA endonuclease activity as compared to that of wild-type (

55 in vitro It is puzzling how such nonspecific endonuclease activity generates primers of appropriate l

56 ut the second first described here, maintain endonuclease activity in the absence of exonuclease acti

57 We found that APE1's endonuclease activity is essential for IgA-class switch

58 hese insertions to a null model, in which L1 endonuclease activity is the sole determinant dictating

59 We also show that endonuclease activity of apurinic/apyrimidinic endonucle

60 h, that a point mutation that eliminates the endonuclease activity of MLH3 eliminates expansions in a

61 g of phosphorylated CtIP, which promotes the endonuclease activity of MRN, to single long (~50 kb) DN

62 lus subtilis, the interaction stimulates the endonuclease activity of MutL and it is critical for DNA

63 We propose a model for the activation of the endonuclease activity of MutL in organisms lacking methy

64 The endonuclease activity of the MutLgamma complex has been

65 is a first-in-class inhibitor targeting the endonuclease activity of the virus polymerase acidic (PA

66 We further reveal that APE1 endonuclease activity on ssDNA but not on dsDNA is compr

67 nt evidence that Integrator utilizes its RNA endonuclease activity to cleave nascent RNA and drive te

68 These dHJs are resolved by endonuclease activity to form exclusively crossovers, wh

69 distinguished by a broad metal-ion-dependent endonuclease activity with specificity for both RNA and

70 folding or assembly defects and near-normal endonuclease activity, but a ~200-fold reduction in stea

71 aining fusion proteins had very little or no endonuclease activity, despite the presence of a putativ

72 the L protein did not exhibit cap-snatching endonuclease activity, it synthesized RNA in vitro RNA p

73 bond formation, RNA polymerase II has an RNA endonuclease activity, stimulated by TFIIS, which rescue

74 ility and while MLH3 does have an associated endonuclease activity, whether that contributes to repea

75 calating loop (Y269) that is critical for AP-endonuclease activity.

76 umed not to be mutagenic, as dCas9 lacks DNA endonuclease activity.

77 ked and then screened for inhibition of APE1 endonuclease activity.

78 ely regulates their transcription via IntS11 endonuclease activity.

79 tions and regions of chromatin accessible to endonuclease activity.

80 n DNASE2, associated with a loss of DNase II endonuclease activity.

81 RNP complex formation, R-loop dynamics, and endonuclease activity.

82 stalled replication forks and stimulates its endonuclease activity.

83 RRM plays an essential role in enhancing its endonuclease activity.

84 bacteria, and catalyze both exonuclease and endonuclease activity.

85 r acid (S-033447) and inhibits cap-dependent endonuclease, an essential protein involved in the initi

86 ed in participants infected with restriction endonuclease analysis (REA) BI and non-BI strains of C.

87 e off-target activity of the Nb.BsmI nicking endonuclease and an engineered spCas9 nickase.

88 first demonstration of a non-RNA-guided Cas9 endonuclease and first step towards eliminating the ribo

89 th purified proteins and DNAs along with DNA endonuclease and in vivo integration assays, we show tha

90 henceforth the rixosome), which contains RNA endonuclease and polynucleotide kinase activities with k

91 ice, we determined the contributions of both endonuclease and redox functions of APE1 in CSR.

92 -stranded breaks made by heterologous I-CeuI endonuclease and the degradation activity of endogenous

93 The endonuclease and the entire cleavage module undergo exte

94 We induce spike-in DSBs by a site-specific endonuclease and use them to quantify detected DSBs (lab

95 system makes use of two Type IIS restriction endonucleases and corresponding vector sets for efficien

96 tiviral defense systems, such as restriction endonucleases and CRISPR, to survive.

97 ediate is thought to shield the AP site from endonucleases and error-prone polymerases.

98 king, characterization of inhibition of APE1 endonuclease, and cytotoxicity of cancer cells were used

99 elongs to a superfamily of exoribonucleases, endonucleases, and phosphatases.

100 gle-strand DNA (ssDNA), whereas the major AP endonuclease APE1 does not.

101 sion repair-associated apurinic/apyrimidinic endonuclease APE1, independent of the BRCA2 status.

102 glycosylase (OGG1) and apurinic/apyrimidinic endonuclease (APE1), respectively.

103 ently processed by the downstream enzyme, AP-endonuclease (APE1).

104 It has been demonstrated that the minor AP endonuclease APE2 contains only one Zf-GRF motif mediati

105 ularly interspaced short palindromic repeat) endonucleases are at the forefront of biotechnology, syn

106 cerevisiae, galactose-inducible rare-cutting endonucleases are commonly used to create a single DSB a

107 Cas12a RNA-guided endonucleases are promising tools for multiplexed geneti

108 CRISPR-associated (Cas) DNA-endonucleases are remarkably effective tools for genome

109 RNA-guided CRISPR-Cas9 endonucleases are widely used for genome engineering, bu

110 The endonuclease Artemis is responsible for opening DNA hair

111 rylated Sae2, along with stimulating the MRX endonuclease as shown previously, also overcomes this in

112 The versatility of CRISPR-Cas endonucleases as a tool for biomedical research has led

113 We induced a site-specific DSB with HO endonuclease at the MAT locus on chromosome III and moni

114 -terminal translocation domain (IUTD) of the endonuclease bacteriocin ColE9 is imported passively acr

115 h3 does not behave like a structure-specific endonuclease but forms polymers required to generate nic

116 e, BRCA2-deficient cells require the 5' flap endonuclease but not the 5'-3' exonuclease activity of F

117 The RNA-guided Cas9 endonuclease can be introduced into cells as a purified

118 ort palindromic repeats and their associated endonucleases (Cas) are an adaptive immune system that e

119 The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets be

120 to reveal the conformational dynamics of the endonuclease Cas9 during its activation toward catalysis

121 ear each other in the structure, forming the endonuclease catalytic center at cosN, the nicking site.

122 Although all Type II restriction endonucleases catalyze phosphodiester bond hydrolysis wi

123 acids inhibit influenza virus cap-dependent endonuclease (CEN) activity.

124 The restriction endonuclease CglI from Corynebacterium glutamicum recogn

125 apsid protein-transcription factor chimeras; endonuclease chimeras; enzymes for detoxification; antim

126 Because endonuclease cleavage is a likely point of regulation fo

127 The MUS81-EME1 endonuclease cleaves late replication intermediates at c

128 The Mlh1-Mlh3 (MutLgamma) endonuclease complex is critical for crossover resolutio

129 s the RtcB ligase and components of the TSEN endonuclease complex.

130 odimer structurally related to the XPF:ERCC1 endonuclease complex.

131 which encodes a subunit of the tRNA splicing endonuclease complex.

132 activation of MUS81-SLX4 structure-specific endonuclease complexes, as well as untimely onset of chr

133 ne SNM1 family and in mRNA 3'-end-processing endonuclease CPSF-73, containing metallo-beta-lactamase

134 cts with FLASH and together they recruit the endonuclease CPSF73 and other polyadenylation factors, f

135 The RNA-guided endonuclease CRISPR-associated protein 9 (Cas9), in part

136 Deployment of RNA-guided DNA endonuclease CRISPR-Cas technology has led to radical ad

137 hanism of a cOA-activated CRISPR defence DNA endonuclease, CRISPR ancillary nuclease 1 (Can1).

138 The endonuclease CtIP is a DNA repair protein that is well-k

139 CUT&RUNTools extracts endonuclease cut site information from sequences of shor

140 The dicer endonuclease DCL3 cuts resulting duplexes to generate 24

141 Nature, 2019) identifies features of the RAG endonuclease deemed to be key in supporting this critica

142 Using a recombinant endonuclease-deficient Cas9-based gene promoter pulldown

143 ted cell lines expressing redox-deficient or endonuclease-deficient proteins, and APX3330-treated mic

144 Here, we identify two endonuclease-deficient, single-component programmable RN

145 uman fixed nuclei are mixed and subjected to endonuclease digestion.

146 , we provide compelling evidence that the L1 endonuclease disproportionately cleaves predominant lagg

147 Structures of Cap4 reveal a promiscuous DNA endonuclease domain activated through ligand-induced oli

148 Hantavirus RdRp has an N-terminal endonuclease domain and a C-terminal uncharacterized dom

149 NYN requires both its KH-like domain and NYN endonuclease domain for antiviral activity.

150 f ALS-033719, which selectively inhibits the endonuclease domain of influenza virus A and B polymeras

151 The purified endonuclease domain of RdRp nonspecifically degraded RNA

152 pped RNA fragments in close proximity to the endonuclease domain of the RdRp for specific cleavage at

153 mino acid polymorphism at position 26 of the endonuclease domain shared by the PA and PA-X proteins.

154 Our work leads to a model of TerL(lambda) 's endonuclease domain where at least three acidic residues

155 We fused the N-terminal endonuclease domain with the C-terminal uncharacterized

156 Thus, acquisition of an endonuclease domain, in conjunction with the ability to

157 role of Polalpha in nicking through putative endonuclease domains but confirm its indirect role in in

158 second messenger; cAAA in turn activates an endonuclease effector, NucC.

159 substitutions in the polymerase acidic (PA) endonuclease exhibited reduced susceptibility to baloxav

160 ng claw that is flexibly appended to an APE2 endonuclease/exonuclease/phosphatase (EEP) catalytic cor

161 tein (NOC) that is highly conserved with the endonuclease/exonuclease/phosphatase (EEP) domain-contai

162 arity to previously crystallized restriction endonucleases facilitated creation of an energy-minimize

163 one or both DNA strands by a Cas protein, an endonuclease, followed by mending of the DNA by repair m

164 representative of this group of restriction endonucleases for detailed characterization.

165 The RNA-guided Cas9 endonuclease from Streptococcus pyogenes is a single-tur

166 XD2, and Exo1 execute resection, and Artemis endonuclease functions to complete the process.

167 DNA site using a catalytically impaired Cas9 endonuclease fused to an engineered reverse transcriptas

168 In mammals, one such apoptogenic protein is Endonuclease G (EndoG), a conserved mitochondrial nuclea

169 We demonstrate here that mouse endonuclease G (mEndoG) shows specificity for both 5hmC

170 In the assay, the HO endonuclease gene is placed between two HO cut sites suc

171 between intron-lacking gene and its adjacent endonuclease gene is the result of co-evolution.

172 While A-EJ-mediated repair of endonuclease-generated breaks requires DNA end resection

173 DNA viruses appear to have evolved from HUH endonuclease genes of various bacterial and archaeal pla

174 PR/Cas) system as a programmable, RNA-guided endonuclease has revolutionized the utilization of gene

175 associated factors, inducible site-specific endonucleases have proven to be fundamental tools.

176 Some inteins contain a homing endonuclease (HEN) responsible for their propagation.

177 The mating-type switching endonuclease HO plays a central role in the natural life

178 We report here that Rad23 can bind Ho-endonuclease (Ho-endo), a nuclear protein that initiates

179 -modification (R-M) systems consist of a DNA endonuclease (HsdR, HsdM and HsdS subunits) and methyltr

180 We find that ErrASE and T7 Endonuclease I are the most effective at decreasing aver

181 an 18-base pair recognition site of a homing endonuclease (I-SceI), which is found by chance only onc

182 ioinformatic information and modeling of its endonuclease, identified five residues, D401, E408, D465

183 is study provided the first prediction of an endonuclease in 10 of the 20 viruses examined; the first

184 a pathway coordinator and structure-specific endonuclease in nucleotide excision repair (NER).

185 opies to investigate UvrC, the dual-incision endonuclease in the bacterial nucleotide excision repair

186 Cas12a (Cpf1) is an RNA-guided endonuclease in the bacterial type V-A CRISPR-Cas anti-p

187 og 1 (Mlh1)-postmeiotic segregation 1 (Pms1) endonuclease in the presence of a mispair and a nick 3'

188 m methylase was found in place of the NgoAXI endonuclease in two of the strains, despite being previo

189 NA-seq) upon expression of these herpesviral endonucleases in order to characterize their effect on t

190 Evolutionarily, how RAG endonucleases in vertebrate immune systems could shed da

191 onical resolvase activity, implying that the endonuclease incises adjacent to junction branch points

192 lagging strand 3'-hydroxyl groups may prime endonuclease-independent L1 retrotransposition in a Fanc

193 which prevents AP endonuclease activity and endonuclease-induced double-strand break formation.

194 es synergistic protection with the influenza endonuclease inhibitor Xofluza.

195 The RAG endonuclease initiates Igh locus V(D)J recombination in

196 The RAG endonuclease initiates Igh V(D)J assembly in B cell prog

197 e synthase (iNOS) and S-nitrosylation of the endonuclease inositol-requiring protein 1alpha (IRE1alph

198 proteins requires incorporation of the Ysh1 endonuclease into an eight-subunit "CPF(core)" complex.

199 he mature mRNA, and thus the activity of the endonuclease is highly regulated.

200 olar localization of the human ITS2 pre-rRNA endonuclease-kinase complex.

201 nternal transcribed spacer 2 (ITS2) pre-rRNA endonuclease-kinase machinery.

202 LAGLIDADG homing endonucleases (LHEs) are a class of rare-cleaving nuclea

203 The enzymes are as follows: MPE, a DNA endonuclease; Lhr-Core, a 3'-5' DNA helicase; LIG, an AT

204 comprises a standalone apurnic-apyrimidinic endonuclease-like domain.

205 ires five enzymatic activities: glycosylase, endonuclease, lyase, polymerase, and ligase.

206 AAA+ GTPase McrB powers DNA cleavage by the endonuclease McrC.

207 Modification dependent restriction endonucleases (MDREs) often have separate catalytic and

208 standing of how genome topology controls RAG endonuclease-mediated assembly of lymphocyte AgR genes.

209 Innate immunity most commonly relies on the endonuclease-mediated cleavage of any incoming DNA that

210 ort palindromic repeats-associated protein 9 endonuclease-mediated gene editing.

211 s distinct Zf-GRF repeat in suppressing APE1 endonuclease-mediated ssDNA breakage.

212 Moreover, we found that knock out of the endonuclease METHYL METHANESULFONATE AND UV SENSITIVE PR

213 ed cleavage site specificity of RNase E, the endonuclease most important for governing mRNA degradati

214 mical specificities, as main actors, the DNA endonuclease MUS81 and the protease WSS1A, and the phosp

215 Cds1 in response to hydroxyurea prevents the endonuclease Mus81 from cleaving the stalled replication

216 Restriction endonucleases naturally target DNA duplexes.

217 The advent of nicking endonucleases (NEases) as signal amplification tools hav

218 recently been reported as another RNA-guided endonuclease of class 2 CRISPR-Cas system, which expands

219 We show that CcCas9 is an active endonuclease of comparatively small size that recognizes

220 PD-(D/E)XK restriction endonucleases of known structure that bind their dsDNA t

221 hased piRNA production requires Zucchini, an endonuclease on the mitochondrial surface.

222 ent induction system to express the yeast HO endonuclease or bacterial restriction enzymes for single

223 ression both at the mRNA level via viral RNA endonuclease PA-X and at the polypeptide level by induci

224 ll as PCNA-dependent activation of MutLalpha endonuclease, PCNA- and DNA-dependent activation of MutL

225 enzymatic activities to shut down the Cas12a endonuclease, providing a multi-turnover off-switch for

226 utation in retinoblastoma binding protein 8, endonuclease (Rbbp8, also known as CtIP), which regulate

227 ition, due to the fast kinetics of the RNase endonuclease reaction, the loaded H(1)/H(2) was quickly

228 by hybrid cleavage with specific restriction endonuclease (REase), and release of trigger oligonucleo

229 BbvCI, a Type IIT restriction endonuclease, recognizes and cleaves the seven base pair

230 HhaI, a Type II restriction endonuclease, recognizes the symmetric sequence 5'-GCG C

231 ctions of Integrator subunits beyond the RNA endonuclease remain poorly understood, but some can act

232 plications of CRISPR-Cas9, an RNA-guided DNA endonuclease, require precision control of Cas9 activity

233 A newly developed inhibitor of the viral endonuclease responsible for this cap-snatching shows th

234 n by covalent fixation, while the concurrent endonuclease restriction eliminates this bias, allowing

235 Combined use of multiple endonucleases resulted in significantly improved sequenc

236 first clinical studies utilizing RNA-guided endonucleases (RGENs) to therapeutically edit RNA and DN

237 CRISPR RNA-guided endonucleases (RGEs) cut or direct activities to specifi

238 onents from a site-specific restriction-like endonuclease (RLE) bearing LINE.

239 te the important role of the low-specificity endonuclease RNase E in shaping the transcriptome of a b

240 ated 5' end to those sites by the regulatory endonuclease RNase E.

241 Overexpression of the RNA:DNA endonuclease RNAse H1 rescues the DNA synthesis defects

242 2'-5'A activates the endonuclease RNase L to cleave single-stranded viral and

243 lates (2'-5'A) that interact with the latent endonuclease RNase L, causing it to dimerize and cleave

244 revealed that loss of the structure-specific endonuclease scaffold SLX4 reduced the proliferation of

245 taining three DNA repair structure-selective endonucleases: SLX1-SLX4, MUS81-EME1, and XPF-ERCC1.

246 of regulation for RNA editing, we elucidated endonuclease specificity in vivo.

247 DSBs in spermatocytes are independent of the endonuclease SPO-11.

248 onstrated with genomic maps of site-specific endonuclease strand-breaks in purified DNA from Escheric

249 Complementation, endonuclease, strand separation, and packaging assays us

250 differences between Mre11 bound to exo- and endonuclease substrates.

251 Dual deficiency of MUS81 structure-specific endonuclease subunit (MUS81) and RECQ1 increased gemcita

252 GTPase activity of McrB is stimulated by the endonuclease subunit McrC.

253 ure termination requires RNA cleavage by the endonuclease subunit of Integrator, but the roles of oth

254 ifficult to achieve(3) because commonly used endonucleases, such as Streptococcus pyogenes Cas9 (SpCa

255 lication proteins (Rep) belonging to the HUH endonuclease superfamily, we show that the replication m

256 ases (Y-CHOPE), incorporating a programmable endonuclease that 'shreds' the Y chromosome, thereby con

257 Cas9 is a prokaryotic RNA-guided DNA endonuclease that binds substrates tightly in vitro but

258 Cas9 is an endonuclease that can be programed to autonomously deliv

259 ply that the mammalian MutLgamma is a unique endonuclease that can initiate triplet repeat DNA expans

260 Fowlpox virus resolvase (Fpr) is an endonuclease that cleaves a broad range of branched DNA

261 myces griseus SgrAI is a type II restriction endonuclease that forms run-on oligomer filaments when a

262 I-PpoI is a homing endonuclease that has a high cleavage activity and speci

263 ida MPE protein is a manganese-dependent DNA endonuclease that incises either linear single strands o

264 mong the 14 subunits of Integrator is an RNA endonuclease that is crucial for the biogenesis of small

265 in yeast, we identify Cue2 as the conserved endonuclease that is recruited to stalled ribosomes to p

266 We show here that human MutLgamma is an endonuclease that nicks DNA.

267 i is a recently identified type V CRISPR-Cas endonuclease that predominantly cleaves the non-target s

268 osylase that generates these sites and an AP endonuclease that processes them.

269 n early steps of mismatch repair as a latent endonuclease that requires a mismatch, MutSalpha/beta, a

270 sequence mapping workflow combining multiple endonucleases that cleave mRNA at different frequencies.

271 Moreover, endonucleases that simultaneously create DSBs in multipl

272 a scaffold protein and coordinates multiple endonucleases that unhook ICLs, resolve homologous recom

273 translesion DNA synthesis and the action of endonucleases that would otherwise generate mutations an

274 tured the pre-mRNA in the active site of the endonuclease, the 73-kilodalton subunit of the cleavage

275 In the presence of FEN1 endonuclease, the major driver of nick translation durin

276 ntrast to the ORFs for PUA domain containing endonucleases, the ORFs for DUF3427 fusion proteins were

277 f the structural and functional diversity of endonucleases throughout the biosphere in DNA restrictio

278 tionality reliant on the ability of the Cas9 endonuclease to introduce site-specific breaks in double

279 ng (the CRISPR guide RNA) can guide the Cas9 endonuclease to specific locations in complex genomes to

280 ationally modeled the local accessibility to endonucleases, to predict the reactivity of twenty sites

281 t single-strand DNA breaks induced by the L1 endonuclease trigger the recruitment of poly(ADP-ribose)

282 on removal is catalyzed by the tRNA splicing endonuclease (TSEN) complex.

283 operties of the well-studied, DNA-guided DNA endonuclease, TtAgo, an Argonaute protein from the Eubac

284 al miRNAs are degraded in human cells by the endonuclease Tudor-SN (TSN).

285 se challenges, we show that Escherichia coli Endonuclease V (eEndoV), an inosine-cleaving enzyme, can

286 Endonuclease V (EndoV) cleaves the second phosphodiester

287 Previous work with the classic T4 endonuclease V digestion of DNA from irradiated Drosophi

288 his capability to demonstrate EndoVIPER-seq (Endonuclease V inosine precipitation enrichment sequenci

289 EndoV-seq utilizes Endonuclease V to nick the inosine-containing DNA strand

290 , ORFs for PUA-superfamily domain containing endonucleases were not close to DNA methyltransferase OR

291 lation of Sae2 activates resection via Mre11 endonuclease, whereas Sae2 phosphorylation by Mec1 and T

292 Streptococcus pyogenes is an RNA-guided DNA endonuclease, which has become the most popular genome e

293 lly toxic structures requires the MUS81-EME1 endonuclease, which is activated at prometaphase by form

294 PF heterodimer is a 5'-3' structure-specific endonuclease, which plays an essential role in several D

295 dent kinase (CDK1/Cdc28) activates the Mre11 endonuclease, while the physiological role of Sae2 phosp

296 Dna2, a flap endonuclease with 5'-3' helicase activity, is involved i

297 se that MPE exemplifies a novel clade of DNA endonuclease within the binuclear metallophosphoesterase

298 hem with CRISPR-Cas12a, a hyper-active ssDNA endonuclease without sequence specificity.

299 The structure-specific endonuclease XPF-ERCC1 participates in multiple DNA dama

300 osome deletion using Orthogonal Programmable Endonucleases (Y-CHOPE), incorporating a programmable en