ライフサイエンスコーパス: endoperoxide

1 cyclization of arachidonic acid to a 15 R-PG endoperoxide.

2 chromophore encapsulated inside a macrocycle endoperoxide.

3 ad no effect on the rate of formation of the endoperoxide.

4 DPA-5Me is converted only very slowly to its endoperoxide.

5 ns, suggest that the nanotube oxide is a 1,4-endoperoxide.

6 mportant in influencing the stability of the endoperoxide.

7 intermediate (9) as found on the pathway to endoperoxide.

8 which is 13.9 kcal/mol less stable than the endoperoxide.

9 g rates of MDA production from prostaglandin endoperoxide.

10 kaloids that contain a unique eight-membered endoperoxide.

11 n to irreversibly yield a highly fluorescent endoperoxide.

12 n by (1)O(2) generated various aldehydes and endoperoxides.

13 xides, bicyclic endoperoxides, and dioxolane-endoperoxides.

14 diation, including the possible formation of endoperoxides.

15 elease of singlet oxygen from the respective endoperoxides.

16 vation of PPARg by interactions with shunted endoperoxides.

17 enation of arachidonic acid to prostaglandin endoperoxides.

18 IsoTxs), are formed by rearrangement of IsoP endoperoxides.

19 nd reversible formation of the corresponding endoperoxides.

20 ve been synthesized and converted into their endoperoxides 1-O2 upon oxidation with singlet oxygen.

21 Provided by total synthesis, endoperoxides 18, 20, and 22 underwent intramolecular ox

22 N-hydroxyphthalimide (NHPI, 5 equiv) formed endoperoxide 2 in 76% yield at ambient temperature.

23 stabilized radicals on rings A and C to form endoperoxide 2.

24 Tricyclic endoperoxide 20 was converted to methyl and benzyl ether

25 urification and identification of ergosterol endoperoxide, a B-ring oxysterol.

26 beta-Carotene-5,8-endoperoxide, a specific marker for singlet oxygen oxida

27 graphy-mass spectrometry analysis to monitor endoperoxide activation by measurement of a stable rearr

28 Heating of the endoperoxides affords the parent anthracenes by release

29 The endoperoxide also undergoes hydrolytic opening followed

30 Therefore, we explored whether the IsoP endoperoxides also undergo rearrangement to form IsoLGs.

31 in the presence of traces of oxygen forms an endoperoxide and a bisepoxide.

32 With selected 1,2-dioxetane, endoperoxide and aroyl peroxide we also establish that t

33 ion of arachidonic acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a

34 Taichunamides C and D contain endoperoxide and methylsulfonyl units, respectively.

35 with the histidyl imidazole ring to form an endoperoxide and then converted to the 2-oxo-histidine (

36 well-characterized antimalarials, including endoperoxides and 4-aminoquinolines, as well as compound

37 methodology expands the synthetic utility of endoperoxides and further underlines their potential as

38 unstable products, such as the prostaglandin endoperoxides and leukotriene A(4) epoxide of mammalian

39 Three endoperoxides and their corresponding tetrahydropyrans e

40 monstrated that hybrid compounds, comprising endoperoxides and vinyl sulfones, were capable of high a

41 peroxides, serial cyclic peroxides, bicyclic endoperoxides, and dioxolane-endoperoxides.

42 eactive oxygen species were produced in both endoperoxide- and tetrahydropyran-treated promastigotes.

43 In spite of the recent increase in endoperoxide antimalarials under development, it remains

44 d artemether, along with the fully synthetic endoperoxide antimalarials, are believed to mediate thei

45 PGH2-like endoperoxides are intermediates in this pathway.

46 We suggest that bicyclic endoperoxides are the major TBARS active compounds prese

47 )) without irradiation and identified a 6,13-endoperoxide as the sole regioisomer.

48 The use of [(18)O]-labeled thermolabile endoperoxides as a source of [(18)O]-labeled (1)O(2) has

49 hysiological pH values, both ASG and the ASG endoperoxide (ASG-EP) do not themselves photosensitize t

50 atalyzed disproportionation of a hydroperoxy endoperoxide available by singlet oxygenation of cyclohe

51 Yet, the mechanisms of most endoperoxide biosyntheses are not well understood.

52 n several cases, the only well-characterized endoperoxide biosynthetic enzyme is prostaglandin H synt

53 roartemisinin, to determine the chemistry of endoperoxide bridge activation to reactive intermediates

54 Desoxyartemisinin lacks an endoperoxide bridge and is ineffective both as an inhibi

55 nd it is hypothesized that activation of the endoperoxide bridge by an iron(II) species, to form C-ce

56 death is a consequence of activation of the endoperoxide bridge to radical species, which triggers c

57 ophenoxy)dihydroartemisinin, which lacks the endoperoxide bridge, was 50- and 130-fold less active in

58 rescein and Cy3) through an Fe(II)-cleavable endoperoxide bridge, where Fe(II)-triggered peroxide cle

59 beta-Carotene endoperoxide, but not xanthophyll endoperoxide, rapidly

60 d through enzymatic metabolism of prostanoid endoperoxides by specific PGE synthases (PGES).

61 Squaraine rotaxane endoperoxides can be stored indefinitely at temperatures

62 Several of the new endoperoxide chemical entities consistently demonstrated

63 ntoxic doses of a chemical compound from the endoperoxide class that decomposes in water generating s

64 ghly conserved alkylation profile, with both endoperoxide classes targeting proteins in the glycolyti

65 ort the first synthesis of the more complex, endoperoxide-containing members of this family.

66 de moieties is well known, the production of endoperoxide-containing oxo-A2E may account, at least in

67 initially formed endoperoxide, otherwise the endoperoxide decomposes to regenerate starting material.

68 n or by thermal decomposition of naphthalene endoperoxide derivatives.

69 urement of a stable rearrangement product of endoperoxide-derived radicals, which was formed in sensi

70 glet oxygen that reacts with alkenes to form endoperoxides, diooxetanes, or hydroperoxides, which are

71 Here, we show that prostaglandin endoperoxide E(2) selectively inhibits activation-induce

72 In vitro studies showed that endoperoxide (EP) 3 and 4 receptors were responsible for

73 Artemisinin, a sesquiterpene lactone endoperoxide extracted from Artemisia annua L (family As

74 While this conformation allows endoperoxide formation between C-11 and C-9, it also imp

75 lectronic factors in the regioselectivity of endoperoxide formation of tetracene derivatives using (1

76 help to unravel the novel mechanism for this endoperoxide formation reaction.

77 ar non-haem iron enzyme that can catalyse an endoperoxide formation reaction.

78 ylalanine, the FtmOx1 catalysis diverts from endoperoxide formation to the more commonly observed hyd

79 whereas electron density is a determinant of endoperoxide formation, steric factors are most importan

80 ort the involvement of singlet oxygen in the endoperoxide formation.

81 nzyme that catalyzes the synthesis of cyclic endoperoxides from arachidonic acid to yield prostagland

82 ty of acenes but also protects the resulting endoperoxides from thermal decomposition.

83 The endoperoxide functional group is both the pharmacophore

84 Their method of degradation via endoperoxide generation was confirmed by X-ray crystallo

85 ponsible for intracellular activation of the endoperoxide group and that this is the chemical basis o

86 to one another make it difficult to form the endoperoxide group from the 11-hydroperoxyl radical.

87 diate is able to add to C-9 to form the 9,11 endoperoxide group of PGG2.

88 Prostaglandin endoperoxide H synthase (COX-2) activity was detected at

89 Prostaglandin-endoperoxide H synthase (PGHS) (EC 1.14.99.1) expression

90 TPA increased prostaglandin endoperoxide H synthase (PGHS) activity and increased th

91 s with specific members of the prostaglandin-endoperoxide H synthase (PGHS) family.

92 en detected during turnover of prostaglandin endoperoxide H synthase (PGHS), and they are speculated

93 The largest difference was seen with PG endoperoxide H synthase (PGHS)-1.

94 Prostaglandin endoperoxide H synthase 2 (PGHS-2) catalyzes the rate-li

95 the amount of immunodetectable prostaglandin endoperoxide H synthase 2 (PGHS-2).

96 duces hyaluronan synthesis and prostaglandin-endoperoxide H synthase 2 in human orbital fibroblasts i

97 annel leads to inactivation of prostaglandin endoperoxide H synthase, the three serine residues in AO

98 clooxygenase (COX) activity of prostaglandin endoperoxide H synthase, which ultimately blocks the for

99 tive and mutant forms of ovine prostaglandin endoperoxide H synthase-1 (oPGHS-1) have suggested that

100 Prostaglandin endoperoxide H synthase-1 (PGHS-1) is expressed constitu

101 d associates functionally with prostaglandin-endoperoxide H synthase-1 (PGHS-1), the constitutive cyc

102 crystal structure of the ovine prostaglandin endoperoxide H synthase-1 (PGHS-1)/S-flurbiprofen comple

103 Increased expression of prostaglandin endoperoxide H synthase-2 (PGHS-2) has been implicated i

104 Prostaglandin endoperoxide H synthase-2 (PGHS-2), also called cyclooxy

105 Prostaglandin endoperoxide H synthase-2 (PGHS-2), also known as cycloo

106 COX-2, formally known as prostaglandin endoperoxide H synthase-2 (PGHS-2), catalyzes the commit

107 diated through an induction of prostaglandin-endoperoxide H synthase-2 (PGHS-2), the inflammatory cyc

108 thasone but not by SC 58125, a prostaglandin endoperoxide H synthase-2 (PGHS-2)-selective inhibitor.

109 Prostaglandin endoperoxide H synthases (PGHS)-1 and -2, also called cy

110 Prostaglandin endoperoxide H synthases (PGHSs) 1 and 2 convert arachid

111 Prostaglandin endoperoxide H synthases (PGHSs) 1 and 2, also known as

112 e cyclooxygenase activities of prostaglandin endoperoxide H synthases (PGHSs) 1 and 2.

113 Prostaglandin endoperoxide H synthases (PGHSs) catalyze the committed

114 clooxygenase (COX) activity of prostaglandin endoperoxide H synthases (PGHSs) converts arachidonic ac

115 Prostaglandin-endoperoxide H synthases (PGHSs) have a cyclooxygenase t

116 Prostaglandin endoperoxide H synthases (PGHSs), also called cyclooxyge

117 Prostaglandin endoperoxide H synthases (PGHSs)-1 and -2 (also called c

118 cyclooxygenase active site of prostaglandin endoperoxide H synthases (PGHSs)-1 and -2.

119 Prostaglandin endoperoxide H synthases 1 and 2 (PGHS-1 and -2) are the

120 Prostaglandin endoperoxide H synthases 1 and 2, also known as cyclooxy

121 Prostaglandin endoperoxide H synthases are targets of nonspecific nons

122 Prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1 and -2) are th

123 Prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1 and -2) conver

124 the crystal structures of the prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1 and PGHS-2), f

125 Prostaglandin endoperoxide H synthases-1 and -2 (PGHSs) can oxygenate

126 Prostaglandin endoperoxide H synthases-1 and -2 (PGHSs) catalyze the c

127 Prostaglandin endoperoxide H synthases-1 and -2, commonly called cyclo

128 The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; als

129 cid called arachidonic acid to prostaglandin endoperoxide H(2) (PGH(2)).

130 of O(2), and two electrons to prostaglandin endoperoxide H(2) (PGH(2)).

131 version of arachidonic acid to prostaglandin endoperoxide H(2) Both COX isoforms are sequence homodim

132 rmational changes in the human prostaglandin endoperoxide H(2) synthase enzyme (PGHS-2).

133 nvert arachidonic acid (AA) to prostaglandin endoperoxide H(2).

134 cal target of acetaminophen is prostaglandin endoperoxide H2 synthase (PGHS).

135 ore, the stereochemistry of Type IV bicyclic endoperoxides has been determined by conversion to penta

136 hensive study of methylated pyridone-derived endoperoxides has led to the development of water-solubl

137 Prostaglandin bicyclic endoperoxides have been detected from the autoxidation o

138 All four possible types (I-IV) of bicyclic endoperoxides have been found starting from different re

139 Although endoperoxides have been suggested as key reaction interm

140 n a freestanding water droplet to produce an endoperoxide in 54-72% yields.

141 ies in which singlet oxygen was generated by endoperoxide in the presence of A2E revealed that vitami

142 e realization of materials that readily form endoperoxides in a self-sensitized manner and then therm

143 The use of artemisinin or other endoperoxides in combination with other drugs is a strat

144 es revealed the presence of (1)O(2)-specific endoperoxides in low-light-grown plants, indicating chro

145 ar addition of 1,3-dicarbonyl equivalents to endoperoxides in the presence of an organocatalyst yield

146 Recent evidence indicates that endoperoxides, including artemisinin and its derivatives

147 In HL-60 cells the endoperoxides induce caspase-dependent apoptotic cell de

148 Overall, these results indicate that endoperoxide-induced cell death is a consequence of acti

149 iring mitochondria play an essential role in endoperoxide-induced cytotoxicity (artesunate IC(50) val

150 l molecular imaging using squaraine rotaxane endoperoxides, interlocked fluorescent and chemiluminesc

151 No endoperoxide intermediate could be detected by low-tempe

152 HKs result from the rearrangement of a di-endoperoxide intermediate formed in the COX-2-dependent

153 everal of the by-products are formed from an endoperoxide intermediate via reactions that are well pr

154 We explored whether isoprostane endoperoxide intermediates also rearrange to levuglandin

155 (COX-1 and COX-2) followed by metabolism of endoperoxide intermediates by terminal PG synthases.

156 IsoP and NPs derive from endoperoxide intermediates that isomerize to D/E-ring fo

157 ormed by reduction and rearrangement of IsoP endoperoxide intermediates, respectively.

158 pounds and PGs is that IsoPs are formed from endoperoxide intermediates, the vast majority of which c

159 of prostaglandins, isoprostanes (isoPs), via endoperoxide intermediates, we postulated previously tha

160 f cyclization of dioxalanyl intermediates to endoperoxide intermediates.

161 ecomposition of the initially formed [4 + 2] endoperoxide into products through a radical chain mecha

162 The major pathway from the endoperoxide is O-O bond cleavage (22.0 kcal/mol barrier

163 The endoperoxide is only formed if ring A is unsaturated and

164 rgo photochemistry at a wavelength where the endoperoxide is transparent, allowing its isolation.

165 staglandin and thromboxane synthase-directed endoperoxide isomerization demonstrated that PGE, PGD, a

166 o probe for a role of P450s in prostaglandin endoperoxide metabolism, we studied the 12-hydroxyheptad

167 Because the cytotoxicity of endoperoxide moieties is well known, the production of e

168 ed dioxolane-isoprostanes) having a bicyclic endoperoxide moiety characteristic of the isoprostanes a

169 mega-chains in the V-shaped pockets, and the endoperoxide moiety interacts with S(gamma) of C110.

170 complex mixture of hydroperoxides, bicyclic endoperoxides, monocyclic peroxides, and serial cyclic p

171 The synthesis of the sesquiterpene endoperoxide natural product 10,12-peroxycalamenene has

172 termediates distinct from previously studied endoperoxide natural products.

173 Neither an endoperoxide nor a dioxetane intermediate was detected b

174 hich a C-8 carbon radical displaces the 9,11-endoperoxide O-O bond to yield an 8,9-11,12-diepoxide th

175 strated in the preferential formation of the endoperoxide of dimethylanthracene in a competition expe

176 )] produced thermally by (18)O-(18)O labeled endoperoxide of N,N'-di(2,3-hydroxypropyl)-1,4-naphthale

177 hydride transfer from the bound NADPH to the endoperoxide of PGH(2) without the participation of spec

178 proceeds with high yield without losing the endoperoxide of the artemisinin backbone.

179 tarate-dependent oxygenase that installs the endoperoxide of verruculogen by adding O(2) between carb

180 or the decomposition of the initially formed endoperoxide, otherwise the endoperoxide decomposes to r

181 o the arachidonic acid-derived prostaglandin endoperoxide PGH(2).

182 the cyclooxygenase metabolite prostaglandin endoperoxide (PGH(2)).

183 alyzed the isomerization of the intermediate endoperoxides, PGH(2)-G and PGH(2)-EA, to the correspond

184 ights into how a cell processes the unstable endoperoxide PGH2 during the inactivation of a major met

185 nverts arachidonic acid to the prostaglandin endoperoxide PGH2, from which all other prostaglandins a

186 e catalyzing the conversion of prostaglandin endoperoxide (PGH2) into thromboxane A2 (TxA2) which pla

187 erium solvent effects, experiments utilizing endoperoxide, phosphorescence, and chemiluminescence que

188 The selective accumulation of beta-carotene endoperoxide points at the PSII reaction centers, rather

189 ted in situ from a readily available hydroxy-endoperoxide precursor.

190 signaling by oxygenating arachidonic acid to endoperoxide precursors of prostaglandins and thromboxan

191 gn and synthesis of a series of biotinylated endoperoxide probe molecules for use in proteomic studie

192 nd a second oxygenation at C-15 to yield the endoperoxide product, prostaglandin G(2).

193 The bicyclic endoperoxide prostaglandin (PG) H2 undergoes nonenzymati

194 rearrangements of the cyclooxygenase-derived endoperoxide, prostaglandin H2, avidly binds to proteins

195 The cyclooxygenase-derived endoperoxide, prostaglandin H2, can undergo rearrangemen

196 At low pH, the endoperoxide protonates to create a hydroperoxide carboc

197 a-Carotene endoperoxide, but not xanthophyll endoperoxide, rapidly accumulated during high-light stre

198 The large difference in endoperoxide reactivity for the two SREP stereoisomers i

199 the PGD(2) 11-ketoreductase and PGH(2) 9,11-endoperoxide reductase activities of PGFS.

200 PGF(2)(alpha) from PGH(2) by the PGH(2) 9,11-endoperoxide reductase activity and 9alpha,11beta-PGF(2)

201 putative catalytic mechanism of PGH(2) 9,11-endoperoxide reductase of PGFS is proposed.

202 amine the catalytic mechanism of PGH(2) 9,11-endoperoxide reductase, a crystal structure of PGFS[NADP

203 neuroprostanes and enhanced DHA, but not AA, endoperoxide reduction in vivo and in vitro.

204 e of fragmentation following Fe(II)-mediated endoperoxide reduction is established.

205 roduces the corresponding squaraine rotaxane endoperoxides (SREPs) quantitatively.

206 en to the imidazole ring to form an unstable endoperoxide, subsequent rearrangement of the endoperoxi

207 We show that endoperoxides such as OZ439, a stable synthetic molecule

208 ion of manganese-reconstituted prostaglandin endoperoxide synthase (Mn-PGHS) with 15-hydroperoxyeicos

209 gh utilization of constitutive prostaglandin endoperoxide synthase (PGHS) -1 and induced PGHS-2, resp

210 matory agents (NSAIDs) bind to prostaglandin endoperoxide synthase (PGHS) and induce a conformational

211 Prostaglandin endoperoxide synthase (PGHS) is a heme protein that cata

212 rostaglandin H(2) synthesis by prostaglandin endoperoxide synthase (PGHS) requires the heme-dependent

213 Prostaglandin endoperoxide synthase (PGHS)-2, the inducible isoform of

214 dependent upon the induced expression of PG endoperoxide synthase (PGHS)-2.

215 itric oxide synthase (NOS) and prostaglandin endoperoxide synthase (PGHS).

216 s time-dependent inhibitors of prostaglandin endoperoxide synthase (PGHS).

217 ngs, we observed that whereas a selective PG endoperoxide synthase (Ptgs) 1 inhibitor SC-560 failed t

218 PGs are derived from arachidonic acid by PG-endoperoxide synthase (PTGS)-1 and PTGS2.

219 BACKGROUND & AIMS: Prostaglandin-endoperoxide synthase (Ptgs)2 is an enzyme involved in p

220 mage involve the activities of prostaglandin-endoperoxide synthase 1 (PTGS1 or cyclooxygenase [COX] 1

221 rate was also not available to prostaglandin endoperoxide synthase 1 in the immediate phase of prosta

222 included IL-1 receptor like 1, prostaglandin-endoperoxide synthase 1, CCL26, and periostin.

223 tions, but only a single gene, prostaglandin-endoperoxide synthase 1/cyclooxgenase 1 (PTGS1/COX1; P =

224 2 (COX-2) gene, also known as prostaglandin-endoperoxide synthase 2 ( PTGS2), occurs in breast cance

225 tamine and proteases, activate prostaglandin-endoperoxide synthase 2 (also called COX2) to increase t

226 ce suggests that inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2) (also known as cyclooxyg

227 receptor 2 (EPHA2), regulates prostaglandin endoperoxide synthase 2 (PTGS2) (encodes COX-2) expressi

228 .02) with a genetic variant in prostaglandin-endoperoxide synthase 2 (PTGS2) (rs12042763).

229 tiation factor 15 (GDF15), and Prostaglandin-endoperoxide synthase 2 (PTGS2) genes, previously shown

230 an expression of PLA(2)G4A and prostaglandin endoperoxide synthase 2 (PTGS2) in wild-type mice.

231 Prostaglandin-endoperoxide synthase 2 (PTGS2) is a key regulatory enzy

232 utively express high levels of prostaglandin-endoperoxide synthase 2 (Ptgs2, also known as Cox-2) alt

233 AF kinases in up-regulation of prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase 2), sugge

234 We found that induction of prostaglandin-endoperoxide synthase 2 (Ptgs2/Cox-2) and prostaglandin

235 1 in the induction of the gene coding for PG-endoperoxide synthase 2 and in the induction of CREB pho

236 ivation-dependent induction of prostaglandin endoperoxide synthase 2 and the supply of arachidonic ac

237 n levels of MIC1 and levels of prostaglandin-endoperoxide synthase 2 expression (PTGS2 or cyclooxygen

238 (TLR signaling-deficient) and prostaglandin-endoperoxide synthase 2(-/-) (Ptgs2(-/-)) mice exhibited

239 A549 cells showed that PTGS2 (prostaglandin-endoperoxide synthase 2) was one of the highly induced g

240 wn as COX2), the gene encoding prostaglandin-endoperoxide synthase 2, allowing activated RAS/P-MAPK-s

241 ly, celecoxib, an inhibitor of prostaglandin-endoperoxide synthase 2, reduced polyp numbers in Apc(Mi

242 The gene expressions of prostaglandin-endoperoxide synthase 2, tissue inhibitor of metalloprot

243 hibition of protein kinase A superinduced PG-endoperoxide synthase 2.

244 docrine factor that stimulates prostaglandin-endoperoxide synthase [cyclooxygenase (Cox)]-independent

245 g the levels of NO synthase or prostaglandin endoperoxide synthase or by inhibiting the release of ar

246 tis to inhibit cyclooxygenase (prostaglandin-endoperoxide synthase), thereby decreasing production of

247 mmon target for these drugs is prostaglandin endoperoxide synthase, also referred to as cyclooxygenas

248 staglandin G/H synthase (PGHS; prostaglandin endoperoxide synthase, cyclooxygenase) by proinflammator

249 ase (COX), also referred to as prostaglandin endoperoxide synthase, is the rate-limiting enzyme for t

250 ion in regulating ET-1-induced prostaglandin endoperoxide synthase, prostaglandin G/H synthase (PGHS)

251 f the constitutively expressed prostaglandin endoperoxide synthase, Ptgs1 (Cox-1), a nuclear receptor

252 nes, is a minor product of the prostaglandin endoperoxide synthase-1 (PG G/H S-1) expressed in human

253 this drug, we expressed human prostaglandin endoperoxide synthase-1 (PGHS-1) and PGHS-2 and purified

254 it arachidonate oxygenation by prostaglandin endoperoxide synthase-1 and -2 (PGHS-1 and -2, respectiv

255 on increases the expression of prostaglandin endoperoxide synthase-2 (PGHS-2) in ovine fetal brain re

256 Site-directed mutants of prostaglandin-endoperoxide synthase-2 (PGHS-2) with changes in the per

257 The prostaglandin endoperoxide synthase-2 (PGS-2) gene encodes an isoform

258 of prostaglandin E(2) and the prostaglandin-endoperoxide synthase-2 (PTGS2, or COX-2) increase in ac

259 hown that forced expression of prostaglandin endoperoxide synthase-2 [also called cyclooxygenase (COX

260 Prostaglandin-endoperoxide synthase-2 inhibition increased slow wave a

261 inocytes from four new donors showed that PG-endoperoxide synthase-2 was dramatically induced by cis-

262 genase-2 (COX-2, also known as prostaglandin endoperoxide synthase-2) signaling cascade plays an esse

263 l-like receptor 4, cryropyrin, prostaglandin-endoperoxide synthase-2, and heparinase genes.

264 mRNA and protein expression of prostaglandin endoperoxide synthase/cyclooxygenase-2 (COX-2), the key

265 2)) and its processing enzyme, prostaglandin-endoperoxide-synthase-2/ cyclooxygenase-2 (PTGS2/COX-2),

266 Prostaglandin endoperoxide synthases (PTGS), commonly referred to as c

267 of constitutive and inducible prostaglandin endoperoxide synthases by serving as a substrate for the

268 ary mode of action in mammals (prostaglandin-endoperoxide synthases) but modulated genes associated w

269 clooxygenase (COX) activity of prostaglandin endoperoxide synthases.

270 Design and synthesis of a guaianolide-endoperoxide (thaperoxide) 3 was pursued as a new antima

271 hraquinones in the presence of oxygen yields endoperoxides that can be reduced to produce 1-hydroxyme

272 The resulting endoperoxide then undergoes additional transformations,

273 ndoperoxide, subsequent rearrangement of the endoperoxide to a dioxirane, and decomposition of the di

274 any role in the reductive activation of the endoperoxide to cytotoxic carbon-centered radicals.

275 ing the rearrangement of an initially formed endoperoxide to give A and B from reaction of 1 with sin

276 s an isomerization of prostaglandin H(2), an endoperoxide, to prostacyclin.

277 ated the selective cytotoxic activity of the endoperoxides toward leukemia cell lines (HL-60 and Jurk

278 The cytotoxic activity of these endoperoxides toward rapidly dividing human carcinoma ce

279 agonist and a thromboxane A(2)/prostaglandin endoperoxide (TP) receptor antagonist, while 3',5'-diiod

280 ivation of the thromboxane-A2 /prostaglandin-endoperoxide (TP) receptor.

281 vely characterized thromboxane/prostaglandin endoperoxide (TP) receptors, from human platelets and ra

282 ICL-1 utilizes a bioinspired endoperoxide trigger to release d-aminoluciferin for sel

283 inhibitor release and quantitatively measure endoperoxide turnover in parasitized red blood cells.

284 Oxabicycloheptane analogs of prostaglandin endoperoxide, U-44069 and U-46619, induced spectral chan

285 ucial for the antileishmanial bioactivity of endoperoxides, under the tested conditions.

286 cture as the SREP-int stereoisomer, with the endoperoxide unit directed inside the macrocycle cavity.

287 e less stable SREP-ext stereoisomer with the endoperoxide unit directed outside the macrocycle.

288 beta-Carotene endoperoxide was found to have a relatively fast turnove

289 The bicyclic endoperoxide was rearranged to a diepoxide with CoTPP.

290 s, arising from rearrangements of anthracene endoperoxides were isolated and characterized.

291 rradiation and form a stable intermediate of endoperoxide, which can then release (1) O(2) in the dar

292 ompounds alpha-linolenic acid and ergosterol endoperoxide, which were active against Cryptococcus neo

293 le via a [4 + 2] cycloaddition to form a 2,5-endoperoxide, which, upon warming, decomposes to a hydro

294 cid (AA) and 2-arachidonylglycerol (2-AG) to endoperoxides, which are subsequently transformed to pro

295 enation of arachidonic acid to prostaglandin endoperoxides, which are the common intermediates in the

296 ise diradical pathway to form cyclohexadiene endoperoxide with an activation barrier of 6.5 kcal/mol

297 E209 is a superior next generation endoperoxide with combined pharmacokinetic and pharmacod

298 Artemisinin is a sesquiterpene endoperoxide with potent antimalarial properties, produc

299 The bicyclic endoperoxides with the two alkyl chains syn on the cyclo

300 water droplet interface and gave the highest endoperoxide yields.