ライフサイエンスコーパス: endophenotype

1 fication of genes relevant for the DS neural endophenotype.

2 e quantitative corticosteroid responsiveness endophenotype.

3 DD, an important aspect of its utility as an endophenotype.

4 d their first-degree relatives as a possible endophenotype.

5 ritable, supporting its value as a potential endophenotype.

6 ucture, allowing refinement of the suggested endophenotype.

7 my of this disease based on the genotype and endophenotype.

8 es in schizophrenia could be an age-specific endophenotype.

9 ational processing as a neural systems-level endophenotype.

10 nction of their classification in a specific endophenotype.

11 nning and white matter hypoplasia within the endophenotype.

12 is a common but relatively understudied TBI endophenotype.

13 between common genetic variability and brain endophenotype.

14 f DISC1 mutation on developmental/anatomical endophenotypes.

15 this heterogeneity is to focus on promising endophenotypes.

16 was sufficient to induce multiple SZ-related endophenotypes.

17 o the post-adolescent onset of schizophrenia endophenotypes.

18 r pathophysiology to circuit and behavioural endophenotypes.

19 nd TREML2 with Alzheimer disease (AD) and AD endophenotypes.

20 ther neurodevelopmental and neuropsychiatric endophenotypes.

21 owth in key cell types may contribute to ASD endophenotypes.

22 hibition were also investigated as cognitive endophenotypes.

23 1,004 individuals were also assessed for the endophenotypes.

24 ggest that this underlies various depressive endophenotypes.

25 abnormalities, revealing potential psychosis endophenotypes.

26 tions that might also be candidate psychosis endophenotypes.

27 ional connections in relatives for potential endophenotypes.

28 and neuronal circuits that underlie disease endophenotypes.

29 n a validated candidate gene and an auditory endophenotypes.

30 py, revealing associations with four or more endophenotypes.

31 s knockout mice is associated with cognitive endophenotypes.

32 ompared to those classified in the other two endophenotypes.

33 ) = 0.30-0.51), supporting their validity as endophenotypes.

34 s, methods for studying the environment, and endophenotypes.

35 ther contribute to severe pathophysiological endophenotypes.

36 al abnormalities resembling neuropsychiatric endophenotypes.

37 ikely focus on the role of rare variants and endophenotypes.

38 eptor ErbB4 in schizophrenia and many of its endophenotypes.

39 Identifying symptom-based endophenotypes across diagnoses may aid gene-finding eff

40 s leveraging cognitive, neuroimaging and CSF endophenotypes, along with age-at-onset data.

41 risk for phenotypes (depression/anxiety) and endophenotypes (amygdala reactivity).

42 la reactivity, a transdiagnostic psychiatric endophenotype and an important stress hormone response t

43 , and both parents underwent a comprehensive endophenotype and clinical characterization.

44 lar mechanisms associated with this peculiar endophenotype and its relations to IR in the obese adole

45 ttle is known about the neurobiology of this endophenotype and no known in vivo molecular imaging stu

46 AnkG isoform imbalance is a novel molecular endophenotype and potential therapeutic target.

47 dentification of distinct PCC/natural season endophenotypes and a partial correlation between the TSS

48 Cav1.2 mechanism in neuropsychiatric-related endophenotypes and a potential future therapeutic target

49 (United States and Denmark), we constructed endophenotypes and assessed their relationship with mort

50 ymorphisms are known and for which molecular endophenotypes and complex traits are assessed on the sa

51 Our results indicate that both neural endophenotypes and genetic variation give rise to the va

52 , they suggest its involvement in DS-related endophenotypes and identify new potential therapeutic st

53 gnitive measures are purported schizophrenia endophenotypes and may represent an intermediate point b

54 mere maintenance) result in diverse cellular endophenotypes and molecular signatures including ER str

55 udies and extreme osteoarthritis phenotypes; endophenotypes and pain; and overlap of osteoarthritis w

56 Pennsylvania, we obtained strikingly similar endophenotypes and relationships to mortality.

57 ards dimensional approaches that incorporate endophenotypes and statistical classification methods.

58 This study supports use of relevant endophenotypes and the bootstrap total significance test

59 quence of the interplay between the relevant endophenotypes and their local, organ-based environment.

60 cript perturbations correlated with clinical endophenotypes and were enriched for genes associated wi

61 erable heterogeneity exists at the genotype, endophenotype, and clinical phenotype levels in cardiova

62 regions linked and/or associated with these endophenotypes, and others previously associated to ADHD

63 loci for social responsiveness validates the endophenotype approach for the identification of genetic

64 enetic findings highlight the utility of the endophenotype approach in enhancing our understanding of

65 tics research on SUDs and the utility of the endophenotype approach in enhancing our understanding of

66 Important examples of such endophenotypes are inflammation, fibrosis, and thrombosi

67 However, alterations in neurogenesis and endophenotypes are not always causally linked, and the r

68 These biomarkers could characterise endophenotypes associated with distinct types of post-tr

69 s-impulsive personality traits may represent endophenotypes associated with the risk of developing co

70 0(-)(5), respectively) illustrating how this endophenotype-based approach can be used to identify new

71 redicting genetic homogeneity by identifying endophenotypes becomes more important.

72 er, the stark similarity in phenotype and/or endophenotype between monkeys and patients suggested tha

73 Those who have the endophenotype but who are not ill nevertheless still suf

74 However, none of these endophenotypes can account for the near-permanent qualit

75 logies, we here investigated whether AD-like endophenotypes can be created in mice by expression of h

76 Elucidating such novel neural endophenotypes can facilitate new approaches to BP predi

77 opened up the possibility of identifying new endophenotypes characteristic of biological substrates u

78 genes to proteins and cellular functions to endophenotypes, cognitive impairments, symptoms, and dia

79 Linkage analyses of the 12 endophenotypes collectively identified one region meetin

80 The wider use of quantitative endophenotypes, combined with unbiased methods for selec

81 disease-specific processes, is to construct endophenotypes comprising linear combinations of physiol

82 ivity has been suggested as a neurocognitive endophenotype conferring risk across a number of neurops

83 Thus, this endophenotype construct may represent an underlying phen

84 We also reproduced the endophenotype constructs, especially the dominant physic

85 e use and ADHD, suggesting impulsivity is an endophenotype contributing to these psychiatric conditio

86 Among the most widely discussed candidate endophenotypes, differences in cerebellar volume have be

87 gree relatives, suggesting that the proposed endophenotype does not generalize to functional brain ac

88 overlapping genetic influences between these endophenotypes early in life.

89 Breaking addiction down into contributing endophenotypes enables its study in a variety of model s

90 ugs, leading to the description of addiction endophenotypes, especially for cocaine addiction.

91 y progression when compared to the other two endophenotypes (FG1 and FG3).

92 e strongest association with AIS patients in endophenotype FG2 (P = 9.9 x 10(-6) and coefficient = -1

93 We found that one endophenotype (FG2) with phosphorylated Galphai(1) and G

94 In the endophenotype FG3 group, we found that patients harborin

95 peptides concentrations could be a suitable endophenotype for a genome-wide association study (GWAS)

96 CSF or plasma APOE levels could be a useful endophenotype for AD and to identify genetic variants as

97 ting that APOE levels in CSF may be a useful endophenotype for AD.

98 ponse time has been proposed as an important endophenotype for attention deficit hyperactivity disord

99 enotype by using social responsiveness as an endophenotype for autism spectrum disorder.

100 brain networks as a potential neurocognitive endophenotype for bipolar disorder and provides evidence

101 as SZR and PBPR perhaps indicating a common endophenotype for both disorders.

102 predisposition to PR interval duration is an endophenotype for cardiovascular disease, including dist

103 f intra-ocular pressure (IOP), an underlying endophenotype for glaucoma.

104 We have identified a brain-based endophenotype for major depressive disorder (MDD) that i

105 It has been proposed as an endophenotype for OCD because it is heritable and more p

106 dysfunction may constitute a neurocognitive endophenotype for OCD, possibly reflecting limbic interf

107 brain circuitry thus emerges as a promising endophenotype for OCD.

108 ntify impaired reward-related learning as an endophenotype for recurrent depression.

109 tle reflex has been suggested as a candidate endophenotype for schizophrenia research, as it shows hi

110 Prolonged PWD may be an endophenotype for several different genetic mechanisms o

111 mon radiographic finding and may be a useful endophenotype for small vessel diseases.

112 ort the idea of an underlying neurocognitive endophenotype for stimulant drug addiction.

113 rected attention, and may represent a useful endophenotype for studying individual differences in att

114 m (EEG) oscillatory activity may be a useful endophenotype for studying the genetics of disorders cha

115 in these structures is considered a putative endophenotype for the disorder.

116 panic disorder, and therefore represents an endophenotype for these disorders.

117 ew objective index of the genetic utility of endophenotypes for any heritable illness.

118 lial risk of BP, and at low risk to identify endophenotypes for BP.

119 TION: Our study demonstrates the efficacy of endophenotypes for broadening our understanding of the g

120 ral signatures that can serve as informative endophenotypes for future genetic studies.

121 ypically use simple activity-based assays as endophenotypes for more complex emotional states of the

122 approach has the potential to discover novel endophenotypes for neuropsychiatric disorders and to bet

123 nd state markers, thus highlighting possible endophenotypes for ongoing research.

124 ic domains, we identified a set of objective endophenotypes for recurrent major depression in a sampl

125 search for neurocognitive and neuroanatomic endophenotypes for schizophrenia in large unselected mul

126 analytic approach, one can discover and rank endophenotypes for schizophrenia, or any heritable disea

127 rtex grey matter volume reductions are valid endophenotypes for schizophrenia, specifically investiga

128 Delta and fast alpha activity were unique endophenotypes for SZ and PBP probands, respectively.

129 er provides a means of identifying potential endophenotypes for this condition.

130 relatives may represent a brain structural 'endophenotype' for DS.

131 cated as a potential intermediate phenotype (endophenotype) for addictive disorders and comorbid exte

132 Impulsivity is an endophenotype found in many psychiatric disorders includ

133 enetic associations with Alzheimer's disease endophenotypes from six brain bank data repositories.

134 he brain vulnerability network represents an endophenotype funneling genetic risks for various psychi

135 A neurocognitive endophenotype has been proposed for stimulant dependence

136 e for susceptibility to four cardiac-related endophenotypes: higher resting heart rate (HR), the elec

137 We tested the endophenotype hypothesis by applying polygenic SNP score

138 first molecular genetic test of the classic endophenotype hypothesis, which states that alleles asso

139 , rather than representing a transdiagnostic endophenotype in ADHD and OCD, were associated with diso

140 be fruitful to use epigenetic tissue age as endophenotype in GWAS.

141 tives that could explain persistence of this endophenotype in the population.

142 t marker in patients with COS, with a milder endophenotype in unaffected siblings associated with res

143 G (b-wave amplitude at Vmax) is a biological endophenotype in young offspring at high genetic risk (H

144 we tested for neuroanatomical and cognitive endophenotypes in a group of adults with ADHD, their una

145 e of PrP(C) to rescue or halt established AD endophenotypes in a therapeutic disease-modifying time w

146 pital fasciculus are putative neurocognitive endophenotypes in adult ADHD.

147 elated and stress-inducible neuropsychiatric endophenotypes in both man and mouse.

148 ular pathways and connect them to behavioral endophenotypes in cognitive disorders has proven to be a

149 h for discovering and empirically validating endophenotypes in extended pedigrees with very few affec

150 Notably, the alterations behave like endophenotypes in families and are linked to ADHD sympto

151 Thereafter, we compared trauma endophenotypes in FND with regional differences in trans

152 her use of white matter integrity markers as endophenotypes in genetic studies.

153 ory information processing (EAP) are used as endophenotypes in genomic studies and biomarkers in clin

154 that plasma Abeta peptides levels are valid endophenotypes in GWASs and can be used to characterize

155 al models have demonstrated disease-relevant endophenotypes in prenatally stressed offspring and have

156 isease neuropathology have been leveraged as endophenotypes in previous genome-wide association studi

157 entary neurocognitive and neurophysiological endophenotypes in schizophrenia probands and their famil

158 ory processing are among the best documented endophenotypes in schizophrenia, possibly due to loss of

159 consortia: the Consortium on the Genetics of Endophenotypes in Schizophrenia, the Project among Afric

160 rs of FBDs, identification of biomarkers and endophenotypes in symptom severity and treatment respons

161 th the onset of IR, and describe a distinct "endophenotype" in obese adolescents characterized by a t

162 s of quantitative intermediate phenotypes or endophenotypes, in tandem with studies of unrelated indi

163 ously demonstrated the heritability of these endophenotypes; in the present study, genetic linkage wa

164 A risk endophenotype included greater activation of cortical at

165 A resilience endophenotype included greater activation of the dorsal

166 Top-ranked endophenotypes included the Beck Depression Inventory, b

167 es are associated with changes of AD-related endophenotypes including cognitive performance, and alte

168 rom the TwinsUK cohort, and glaucoma-related endophenotypes, including intraocular pressure (IOP), ve

169 al and biologic intermediate phenotypes (or 'endophenotypes') indexing anxiety-proneness offers an im

170 s and controls (N = 3428) from the Psychosis Endophenotypes International Consortium (PEIC).

171 We further demonstrated that each endophenotype is conserved among affected family members

172 ing the imaging quantitative traits (QTs) as endophenotypes is an important task in brain science.

173 ted effort to fully exploit the potential of endophenotypes is overdue.

174 dysgenesis, which can be regarded as a MCOR endophenotype, is consistent with the view that deletion

175 By studying endophenotypes it is possible to both dissect psychiatri

176 Electrophysiological endophenotypes lie between risks and symptoms and have t

177 nd/or associated to ADHD, suggest that these endophenotypes lie on shared pathways.

178 evidence that the defect characterizing each endophenotype lies at the level of Galphai proteins lead

179 eterogeneity of MDD by focusing on promising endophenotypes linked to specific pathophysiological abn

180 ) exhibiting pleiotropic effects on both the endophenotype (lymphocyte-derived expression levels of t

181 This abnormality may be a structural endophenotype marking risk for psychotic illness and it

182 Additional genetic studies of this endophenotype may help identify genetic variants or netw

183 Such endophenotypes may also permit a deeper exploration of t

184 The identification of addiction endophenotypes may be useful in facilitating the rationa

185 h linking epigenetic variability with neural endophenotypes may broadly explain individual difference

186 tended family design, we used a quantitative endophenotype, measured in all individuals: number of al

187 t studies here, and suggest how neuroimaging endophenotypes might prove useful for the development of

188 totic disruption that displays schizophrenic endophenotypes modulated by prenatal factors and reversi

189 We created a human calcification endophenotype module (ie, the "calcificasome") by mappin

190 calcificasome overlapped significantly with endophenotype modules governing inflammation, thrombosis

191 animal models for the study of schizophrenia endophenotypes, namely the phencyclidine (PCP) mouse mod

192 In this study, we construct endophenotype network models and explore their relation

193 Endophenotypes (neurobiological markers that cosegregate

194 In ALS endophenotypes, neuroimaging has also shown a diverse sp

195 al visual engagement as a neurodevelopmental endophenotype not only for autism, but also for populati

196 s a potential candidate for a neurocognitive endophenotype of ADHD.

197 vation identified may represent a functional endophenotype of autism, related to familial risk for th

198 Therefore, hyperexcitability is one early endophenotype of bipolar disorder, and our model of iPSC

199 ient prediction error signal, as a candidate endophenotype of bipolar disorder.

200 Impulsivity is a validated endophenotype of both bipolar disorder and suicidal beha

201 ogy of mood disorders and could represent an endophenotype of depression.

202 patients and siblings, and so constitutes an endophenotype of juvenile myoclonic epilepsy.

203 se activity, and can be construed as a novel endophenotype of juvenile myoclonic epilepsy.

204 m underlying an inhibitory control cognitive endophenotype of LLD.

205 led axial length increase in the mutant (the endophenotype of myopia).

206 motor area hyperactivity is a neurocognitive endophenotype of OCD that is possibly related to ineffic

207 Deficient response inhibition is a promising endophenotype of OCD, although its functional neural cor

208 es of working memory may be a neurocognitive endophenotype of OCD.

209 tal plasticity and learning as a provisional endophenotype of PD would facilitate investigation of th

210 into an established and clinically relevant endophenotype of prodromal HD.

211 hypothesis that network randomization is an endophenotype of schizophrenia and therefore evident als

212 4 polymorphisms also affect another proposed endophenotype of schizophrenia, namely sensory gating as

213 sured by prepulse inhibition--an established endophenotype of schizophrenia.

214 bility to genetically improve the behavioral endophenotype of Syngap1 mice decreased slowly over post

215 ing cognitive processes and may represent an endophenotype of the disease.

216 ulsive disorder (OCD) research and may be an endophenotype of the disorder.

217 erative diseases, suggesting these may be an endophenotype of the disorders.

218 Impulsivity is an endophenotype of vulnerability for compulsive behaviors.

219 s that impulsivity may be a transnosological endophenotype of vulnerability to compulsivity.

220 of genetically and spatiotemporally distinct endophenotypes of ASD.

221 en implicated in many behavioral domains and endophenotypes of autism, including abnormal neural sign

222 Three putative endophenotypes of depression were found to have partiall

223 mine the neural correlates of three emerging endophenotypes of depression: neuroticism, blunted rewar

224 elopment of behavioral and neuropathological endophenotypes of disease.

225 Although neural endophenotypes of heightened or extreme antisocial behav

226 etween resting state EEG current density and endophenotypes of interest.

227 nsitive behaviors and is required to mediate endophenotypes of mania and depression in rodents.

228 in excitatory synapses can cause behavioral endophenotypes of mental illness.

229 abnormal behaviors that are often considered endophenotypes of schizophrenia and autism spectrum diso

230 models of synaptic dysfunction demonstrated endophenotypes of schizophrenia as well as bioenergetic

231 nhibitor MS-275 both cognitive and molecular endophenotypes of schizophrenia can be rescued in p35 he

232 y contributes to genetic modulation of known endophenotypes of schizophrenia-like higher-level cognit

233 otential in mice and rats, respectively, two endophenotypes of schizophrenia.

234 Bipolar I disorder is highly heritable, but endophenotypes of the disorder mediating genetic risk ar

235 s and weight loss, two of the most prominent endophenotypes of the HD-like disease in mice.

236 adult-born hippocampal neurons with specific endophenotypes of these disorders.

237 Improving endophenotyping of sensitized bronchiectasis, a clinical

238 ves, suggesting that this is a systems-level endophenotype or marker of familial risk.

239 eptor systems that may be implicated in this endophenotype or the phenotypic expression of trauma-rel

240 sification of patients into three biological endophenotypes or functional groups (FG1, FG2 and FG3).

241 into more homogeneous subgroups based on the endophenotype [panel of biomarkers]) with the aim to ref

242 We identified in rodents an innate endophenotype predicting individual risk for alcohol-rel

243 ency could represent a stress susceptibility endophenotype predisposing to the development of trauma-

244 The most dominant endophenotype primarily reflected the physical activity

245 Applying endophenotype ranking value analysis to a high-dimension

246 Here, we describe the endophenotype ranking value, a new objective index of th

247 case the shifting research landscape towards endophenotype refinement in clinical and preclinical set

248 Measuring cognitive endophenotypes related to both the disorder and mechanis

249 mice lacking CRTC1 associate neurobehavioral endophenotypes related to mood disorders.

250 tergic neurons promotes the manifestation of endophenotypes related to psychiatric disorders includin

251 The analyses identified two heritable endophenotypes related to Tourette syndrome that cross t

252 or magnitude and replicability of behavioral endophenotypes relevant to autism and Phelan-McDermid sy

253 ate homeostasis, thought to underlie several endophenotypes relevant to schizophrenia.

254 ed as being heterogeneous, the extent of its endophenotypes remains unclear.

255 educed expression, as well as the behavioral endophenotypes reminiscent of those observed in the abov

256 serine phosphorylation patterns for each AIS endophenotype resulting in a differential reduction in G

257 urther analysis using additional cohorts and endophenotypes revealed that rs165940 principally associ

258 d area of the brain recapitulates behavioral endophenotypes seen in humans diagnosed with autism (anh

259 ty yet impaired spatial learning and memory, endophenotypes similar to those of NMDA receptor knock-d

260 e to other psychiatric disorders to identify endophenotype-specific responses relevant to neurobiolog

261 tify DMNs and to test their biomarker and/or endophenotype status.

262 Endophenotype studies of obsessive-compulsive disorder (

263 the effects of genetic variation on relevant endophenotypes, such as hippocampal volume loss.

264 n a similar set of core electrophysiological endophenotypes, suggesting the possibility of a shared n

265 se data support the idea that PPI is a valid endophenotype that can be used to explore the genetic ar

266 Thus, gene expression is an endophenotype that can lead to the discovery of the unde

267 Attentional bias to threat is a key endophenotype that contributes to the chronicity of trau

268 his mechanism represent a microcircuit-level endophenotype that could link diverse genetic and develo

269 ce that reduced spindle activity in SZ is an endophenotype that impairs sleep-dependent memory consol

270 that overactive performance monitoring is an endophenotype that indicates vulnerability for OCD.

271 ished serotonergic tone in the OFC may be an endophenotype that predisposes to behavioral inflexibili

272 atter, WM growth may also be an age-specific endophenotype that shows compensatory normalization with

273 orrects the altered behavioral and molecular endophenotypes that are typical of PRS mice.

274 ion deficits in these nodes may be useful as endophenotypes that extend beyond the affected individua

275 inct from behavioral or neuropharmacological endophenotypes that have been previously implicated as t

276 uroeconomics can provide promising candidate endophenotypes that might help clarify the basis of high

277 ISC1) confers a genetic risk at the level of endophenotypes that underlies many major mental disorder

278 non-clinical phenotypes, including putative endophenotypes, that can be used to study domains of nor

279 nfluence on ADHD vulnerability, and disorder endophenotypes through modulation of the serotonergic sy

280 f mammalian behaviour, from neuropsychiatric endophenotypes to circadian rhythms.

281 ariants are transmitted through intermediate endophenotypes to modulate organismal traits remains a c

282 at integrate transcriptomic, epigenetic, and endophenotype traits with systems biology to annotate ge

283 Endophenotypes, traits genetically correlated with an il

284 ophrenia-1 (DISC1), a factor that influences endophenotypes underlying schizophrenia and several othe

285 ates that selection of ASD subjects based on endophenotypes unraveled biologically relevant pathway d

286 omposite and clinical phenotypes measure the endophenotype using treatment effect area under the rece

287 d association analyses to neuropsychological endophenotypes using microsatellite and single nucleotid

288 ls with ASD, and, critically, whether neural endophenotypes vary as a function of aggregate genetic r

289 Heritability estimates for both endophenotypes were high and statistically significant (

290 Associations with endophenotypes were observed for 46 genes of potential f

291 identified heritable, schizophrenia-related endophenotypes were observed, and several genes of poten

292 , selected schizophrenic-like phenotypes and endophenotypes were rescued by chronic haloperidol treat

293 We also identified an ABHD6(High) SLE endophenotype wherein reduced local abundance of 2-AG re

294 n siblings are likely to be an age-dependent endophenotype, which normalize by the typical age of ons

295 ulation the composite phenotype measured the endophenotype with an AUC of 0.74, significantly exceedi

296 Thus AMD most likely represents an endophenotype with differing underlying pathogenesis in

297 The composite phenotype measured the endophenotype with higher accuracy, higher stability acr

298 istribution are associated with SLE clinical endophenotypes, with genes of the interferon pathway bei

299 iate biological phenotypes in the context of endophenotypes within distinct behavioural domains.

300 the dominant physical activity and pulmonary endophenotype, within demographic subpopulations of thes