ライフサイエンスコーパス: endoreduplication

1 that are developmentally stable and void of endoreduplication.

2 rvening mitotic division, a process known as endoreduplication.

3 ndosperm transition from mitotic division to endoreduplication.

4 geminin is part of the mechanism regulating endoreduplication.

5 noblastoma protein phosphorylation, limiting endoreduplication.

6 f nutrient acquisition induce localized host endoreduplication.

7 gulated during "all JAKs inhibitor"-mediated endoreduplication.

8 , resulting in either mitotic catastrophe or endoreduplication.

9 to the mitotic stage preceding the onset of endoreduplication.

10 g of the divergence is near-synchronous with endoreduplication.

11 age, impaired proliferation, and chromosomal endoreduplication.

12 e fraction of cells in G(2)/M and undergoing endoreduplication.

13 creased enzyme activity but had no effect on endoreduplication.

14 d, S phase wt cells also elicited a state of endoreduplication.

15 se, while preserving diploidy by suppressing endoreduplication.

16 which promote cell proliferation and repress endoreduplication.

17 ls, while preserving diploidy by suppressing endoreduplication.

18 This phenomenon is known as endoreduplication.

19 as well as defects in fertility and gut-cell endoreduplication.

20 3) are consistent with a function for SIM in endoreduplication.

21 on is involved in the cellular transition to endoreduplication.

22 as effectively blocked, so that there was no endoreduplication.

23 yclin B1/Cdc2 activity and the occurrence of endoreduplication.

24 evelopment imply that ZmWee1 plays a role in endoreduplication.

25 conditions that gave relatively synchronous endoreduplication.

26 xit from the mitotic cell cycle and onset of endoreduplication.

27 resulted in a higher tendency to undergo DNA endoreduplication.

28 of try, it synergistically enhanced trichome endoreduplication.

29 f chromosomal segregation, and underwent DNA endoreduplication.

30 tored cyclin E/Cdk2 regulation and prevented endoreduplication.

31 r mitotic bypass, allowing cells to complete endoreduplication.

32 ide, but still replicate DNA, leading to DNA endoreduplication.

33 romote mitotic bypass, a key step in WGD via endoreduplication.

34 teristics, despite showing normal growth and endoreduplication.

35 synchronously from the mitotic cell cycle to endoreduplication.

36 icating that KRP5 is a positive regulator of endoreduplication.

37 nsible for mitotic exit and earlier onset of endoreduplication.

38 2, operating as a rate-determining factor of endoreduplication.

39 erved specifically in cells known to undergo endoreduplication.

40 persistent p21 expression and resistance to endoreduplication.

41 preventing improper cell cycle re-entry and endoreduplication.

42 s, a defect we associate with an increase in endoreduplication.

43 Targeting all JAKs also caused endoreduplication 48 and 72 hours after treatment.

44 Endoreduplication, a modified cell cycle that allows cel

45 Giant cells have undergone endoreduplication, a specialized cell cycle in which cel

46 tes: (i) a low percentage of cells undergoes endoreduplication, achieving higher than 4n ploidy, and

47 at STM inhibits cellular differentiation and endoreduplication, acting through CK and the CK-inducibl

48 y identifies cells with different mitotic or endoreduplication activities in the root cortex.

49 lating the postmitotic checkpoint to prevent endoreduplication after an aberrant mitosis.

50 116 and U2OS), and both cell lines underwent endoreduplication after Nutlin-3a removal.

51 and CDC2 in Nutlin-3a-treated cells and for endoreduplication after Nutlin-3a removal.

52 on megakaryocytic colony growth and nuclear endoreduplication, alone or in the presence of thrombopo

53 mponents manipulated to promote induced host endoreduplication and (b) biotroph effectors that facili

54 w that MeJA activates critical regulators of endoreduplication and affects the expression of key dete

55 In contrast, RO3306 induced abortive endoreduplication and apoptosis in embryonic stem cells,

56 Endoreduplication and apoptosis in response to VX-680 ar

57 In contrast, endoreduplication and apoptosis occur in the p53 wild-ty

58 ein phosphorylation, followed by progressive endoreduplication and apoptosis.

59 cycle, the cell will likely enter a state of endoreduplication and become giant.

60 tive NCI-H1299 cells inhibits VX-680-induced endoreduplication and cell death.

61 nts, less is known about the coordination of endoreduplication and cell differentiation.

62 kernels when endosperm cells were undergoing endoreduplication and cell division.

63 a to characterize developmental progression, endoreduplication and cell division.

64 y a role in arresting mitosis during the DNA endoreduplication and cell expansion phase of seed devel

65 ion occurred without cell division involving endoreduplication and cell growth, thereby circumventing

66 an unexpected yet specific role of SEC24A in endoreduplication and cell size patterning in the Arabid

67 could bind chromatin to coordinately control endoreduplication and chromatin structure and allow the

68 e G2 phase of the cell cycle, accompanied by endoreduplication and consequently polyploidization.

69 Shared mechanisms to promote host endoreduplication and development of nutrient exchange/f

70 of cell proliferation and the transition to endoreduplication and differentiation during organ forma

71 lar regulatory pathways to drive S. meliloti endoreduplication and differentiation during symbiosis.

72 ell division by regulating the transition to endoreduplication and differentiation.

73 tivation, and the strong association between endoreduplication and impaired proliferation, may place

74 due to inhibition of Aurora kinases included endoreduplication and inhibition of histone H3 phosphory

75 ybridisation (CGH) showed mutually exclusive endoreduplication and loss of heterozygosity events in c

76 telet production and function by stimulating endoreduplication and megakaryocyte formation from marro

77 We now report that endoreduplication and mitotic failure occur during telom

78 ependent manner by stimulating megakaryocyte endoreduplication and new megakaryocyte formation from m

79 ype and that diploidisation is the result of endoreduplication and not cell fusion.

80 1) modulates a number of processes including endoreduplication and plant disease resistance, but the

81 oly-(ethylene glycol), induces megakaryocyte endoreduplication and proliferation in vitro and in vivo

82 Loss-of-function alleles show reduced endoreduplication and reduced expansion in trichomes and

83 tokinesis failure, causing several rounds of endoreduplication and resulting in multinucleated cells.

84 me amplification, abnormal spindle assembly, endoreduplication and significant chromosome instability

85 times complete only the first two rounds of endoreduplication and stall at 8C.

86 xpand during early development, undergo more endoreduplication and that have a striking nuclear morph

87 plex co-ordination of cell division, growth, endoreduplication and the acquisition of differentiated

88 nt of p53 wild-type cancer cells can promote endoreduplication and the generation of therapy-resistan

89 ther cells are susceptible to Nutlin-induced endoreduplication and therapy resistance could help dire

90 by specifically affecting cell enlargement, endoreduplication and/or cell division.

91 posable elements (TEs), is maintained during endoreduplication, and drops precipitously within the ge

92 l and phosphorylation state concomitant with endoreduplication, and it is phosphorylated in vitro by

93 vent a DNA damage signal at chromosome ends, endoreduplication, and senescence.

94 ppresses development of an abnormal state of endoreduplication arising after S phase DNA damage.

95 acute chromosomal aberrations and underwent endoreduplication at a high rate.

96 f inner cell mass (ICM) and causes premature endoreduplication at eight cells, rather than 32 cells.

97 y at high concentrations but cause bacterial endoreduplication at sublethal concentrations.

98 Here, we show that variation in endoreduplication between Arabidopsis thaliana accession

99 ts revealed that p57 was required to trigger endoreduplication by inhibiting CDK1, while p21 suppress

100 the developmental transition from mitosis to endoreduplication by modulating anaphase-promoting compl

101 ay function as a repressor of mitosis in the endoreduplication cell cycle.

102 Both the mitotic and endoreduplication cell cycles were stimulated.

103 breast cancer cell lines and results in the endoreduplication (cellular DNA content >4N) of MCF-7 an

104 nism by which this occurs is via postmitotic endoreduplication checkpoint and mitotic catastrophe.

105 of p53 or reduced ERK signaling allowed for endoreduplication, completing a WGD event.

106 Plant cells often undergo endoreduplication, confounding the polyploid effect.

107 Successful progression of the endoreduplication cycle in Arabidopsis requires a plant

108 he switch from the mitotic cell cycle to the endoreduplication cycle, which accompanies cell expansio

109 ping roles during the mitotic cell cycle and endoreduplication cycle.

110 Medicago truncatula is driven by successive endoreduplication cycles and transcriptional reprogrammi

111 e nuclear area, suggesting the activation of endoreduplication cycles linked to the cytokinin-regulat

112 the tendency of Rb-negative cells to undergo endoreduplication cycles when p21 is expressed may have

113 amplify its chromosomal DNA content through endoreduplication cycles.

114 nvestigated how the epigenome changes during endoreduplication cycles.

115 Our results suggest that endoreduplication-dependent epigenetic changes contribut

116 The lower level of endoreduplication did not affect cell size and only slig

117 Endoreduplication disrupts the alternation of DNA synthe

118 Mitotic exit and onset of endoreduplication do not correlate with an up-regulation

119 cts to promote cell division and/or suppress endoreduplication during leaf development.

120 Genome endoreduplication during mammalian development is a rare

121 h cells end their mitotic division and start endoreduplication earlier.

122 o, bacteroid differentiation is driven by an endoreduplication event that is induced by host nodule-s

123 gellar component knockdowns linked to genome endoreduplication, evidence for metabolic control of the

124 eckpoint function are more likely to undergo endoreduplication followed by eventual apoptosis.

125 NDING PROTEIN1, induces early termination of endoreduplication followed by late divisions of polyploi

126 To study the genetic regulation of endoreduplication, four inbreds were crossed to B73 and

127 Endoreduplication gave rise to stable tetraploid clones

128 described quantitative trait gene underlying endoreduplication in Arabidopsis.

129 ons rendered E7 unable to induce S phase and endoreduplication in differentiated keratinocytes and re

130 y dictate cell cycle arrest; but suppressing endoreduplication in endocycling cells, an effect that c

131 ometry was used to assess the variability of endoreduplication in endosperms of maize inbred lines.

132 genes is associated with a higher degree of endoreduplication in enlarged C(4) bundle sheath cells.

133 CT116 p21(+/+) cells paralleled the onset of endoreduplication in HCT116 p21(-/-) cells.

134 n proliferating tissues and also compromises endoreduplication in larval salivary glands.

135 FZR2 is sufficient to drive ectopic or extra endoreduplication in leaves, roots, and flowers, leading

136 During the transition from mitosis to endoreduplication in maize endosperm, CycZme1 transcript

137 We conclude that cellular programming during endoreduplication in megakaryocytes is associated with r

138 assembly of prereplication complexes and for endoreduplication in megakaryotes and giant trophoblast

139 copersicum), this process is associated with endoreduplication in mesocarp cells.

140 We previously documented endoreduplication in mouse cells with persistent telomer

141 quantitative analysis of DNA replication and endoreduplication in nuclei from pulse-labeled developin

142 ediately after Nutlin-3a removal could drive endoreduplication in otherwise resistant 4N cells.

143 Furthermore, we show that MTI-induced endoreduplication in p53-deficient HIp21 cells was due t

144 ion of the cell cycle and for suppression of endoreduplication in pupal wing cells.

145 on increases chromocenter decondensation and endoreduplication in the Arabidopsis trithorax-related p

146 al and mesophyll cell number, a reduction in endoreduplication in the epidermis, and an increase in e

147 r, smaller cell volume, and reduced level of endoreduplication in the mutant endosperm.

148 pendent quiescent center differentiation and endoreduplication in the primary root tip.

149 es during the transition from replication to endoreduplication in the Rcho-1 rat choriocarcinoma cell

150 ies was associated with abnormal mitosis and endoreduplication in the recovering cells and was correl

151 To investigate this process, we reduced endoreduplication in transgenic maize endosperm by ectop

152 ication in the epidermis, and an increase in endoreduplication in trichomes.

153 n of the ectoplacental cone and chorion, and endoreduplication in trophoblast giant cells.

154 Thus, endoreduplication in TS cells is triggered by p57 inhibi

155 gression in both cell lines, with associated endoreduplication in U2OS cells.

156 required for both mitosis and prevention of endoreduplication in wing cells.

157 m, called bacteroid, characterized by genome endoreduplication, increased cell size, and high membran

158 g cells, and loss of KRP5 function decreases endoreduplication, indicating that KRP5 is a positive re

159 Localized host endoreduplication induced by adapted plant biotrophs pro

160 The G2-M arrest and endoreduplication induced by JAK inhibitors were reduced

161 ill be consolidated into a single strain by "endoreduplication intercross." Chemically synthesized ge

162 ultiple synthetic chromosomes using advanced endoreduplication intercrossing with tRNA expression cas

163 Endoreduplication is a process by which cells successive

164 Endoreduplication is also reduced in dark-grown sim hypo

165 Endoreduplication is different between inbred lines by 1

166 Endoreduplication is found in animals and is widespread

167 When induced host endoreduplication is limited, biotroph growth and/or dev

168 Endoreduplication is the process where a cell replicates

169 Although the role of endoreduplication is unclear, it is thought to provide a

170 Although endoreduplication is widespread in eukaryotes, we know v

171 Endoreplication, also known as endoreduplication, is a modified cell cycle in which DNA

172 Endoreplication, also called endoreduplication, is a modified cell cycle in which DNA

173 Endoreplication, also known as endoreduplication, is a phyogenetically widespread modif

174 to its described activity as a repressor of endoreduplication, KAK may play a role in vascular devel

175 host cells invaded by the pathogen involves endoreduplication leading to increased ploidy levels.

176 GL1 overexpression also reduced endoreduplication levels in both the epidermis and trich

177 Parental and progeny endoreduplication levels were compared and heritabilitie

178 rb3 mutant roots, expression of the MtCCS52A endoreduplication marker was reduced.

179 The resistance to endoreduplication observed in some cell lines was associ

180 urther experimentation revealed induced host endoreduplication occurred exclusively at the infection

181 imilar arrest distributions [corrected], DNA endoreduplication occurred in pRb-negative but not in pR

182 work, we show that some, but not all, of the endoreduplication of Arabidopsis (Arabidopsis thaliana)

183 thout cytokinesis and subsequently underwent endoreduplication of DNA despite activation of a p53-dep

184 es DA1 peptidase activity, thereby promoting endoreduplication of host tissues to support pathogen gr

185 in progeny of ASI2 germ line knockouts, but endoreduplication of the macronuclear genome is arrested

186 profound cellular differentiation, including endoreduplication of the ome.

187 revealing that inactivation of CDK1 triggers endoreduplication only in cells programmed to differenti

188 to oxygen deprivation and could form through endoreduplication or cell fusion, generating regular-siz

189 the p21Waf1/Cip1 activated G2 block undergo endoreduplication, passing through another S-phase befor

190 tory activity that peaks coincident with the endoreduplication phase of endosperm development.

191 test the feasibility of introgressing a high endoreduplication phenotype into a midwestern dent inbre

192 ingly, mutant root hairs complete the normal endoreduplication programme, increasing their nuclear pl

193 ted synthesis of the defective enzyme to the endoreduplication rather than the mitotic phase of endos

194 lei of sim trichomes have a reduced level of endoreduplication relative to WT trichome nuclei.

195 enlarged polyploid beta cells as a result of endoreduplication replacing proliferation.

196 Conversely, endoreduplication represses small cell identity.

197 but did not prevent G1/S transition so that endoreduplication resulted.

198 t, by increasing gene copy number, localized endoreduplication serves as a mechanism to meet the enha

199 scued clones prevented without also inducing endoreduplication, suggesting that these two key roles f

200 gene expression with high and low levels of endoreduplication, suggesting that this process may not

201 characterized by mitotic cell proliferation, endoreduplication, the accumulation of storage compounds

202 To determine how p21 prevents MTI-induced endoreduplication, the G1/S and G2/M checkpoint pathways

203 hat CDKA;1 is epistatic to RBR1 and controls endoreduplication through an RBR1-dependent pathway.

204 nstrated that the induction of p21 inhibited endoreduplication through direct cyclin E/Cdk2 regulatio

205 However, some cell lines underwent endoreduplication to relatively high extents after Nutli

206 m with either of two other mutants affecting endoreduplication, triptychon (try) and glabra3 (gl3) ar

207 size and leaf ploidy levels, suggesting that endoreduplication underpins leaf thickness in tomato.

208 Induced endoreduplication was abrogated in myb3r4 mutants, and G

209 arrest of the mitotic cycle at the onset of endoreduplication was associated with a failure to assem

210 Three measurements of endoreduplication were calculated from these data and an

211 o significant difference in nucleus size and endoreduplication were detected in rhizobia-infected rrb

212 en midwestern dent types, and high levels of endoreduplication were observed in popcorns.

213 TS cells revealed that CDK2 is required for endoreduplication when CDK1 is inhibited.

214 mitosis, on the one hand, and prevention of endoreduplication when cells are arrested in G2, on the

215 s in a substantial increase in the degree of endoreduplication, whereas inducible expression of p21(W

216 es during the cell-cycle but also suppresses endoreduplication, which is associated with polyploidy a

217 with a >/=4N DNA content, a process known as endoreduplication, which results in polyploidy.

218 tion, a period that encompasses the onset of endoreduplication, while the Zeama;KRP;2 protein decline

219 a mays) endosperm undergo multiple cycles of endoreduplication, with some attaining DNA contents as h

220 WGD can result from mitotic errors or endoreduplication, yet the molecular mechanisms that dri