ライフサイエンスコーパス: endosomal

1 regulation of CHMP1B ubiquitination triggers endosomal accumulation and subsequent activation of VEGF

2 Mechanistically, Hvcn1 deficiency delayed endosomal acidification and enhanced intracellular react

3 tionally coupled during H(+)-ATPase-mediated endosomal acidification, crucial for ClC-5 activation by

4 nce facilitated further H(+)-ATPase-mediated endosomal acidification.

5 cytosis, subcellular location, or changes in endosomal acidification.

6 ting their lysosomal degradation through its endosomal actin nucleation activity.

7 r with Glu-719 and Glu-721, it increases the endosomal activity of PC7 on hTfR1.

8 Here, we investigate the role of the endosomal adaptor Tollip during the mitochondrial stress

9 a novel physiological role for this ancient endosomal agent.

10 Btk29A regulate WASH activity to balance the endosomal and cortical F-actin networks during epithelia

11 n exosome production plays a primary role in endosomal and lysosomal deficits that occur in apolipopr

12 d human ECs internalize MAC, triggering both endosomal-associated NIK-dependent NLRP3 inflammasome as

13 cromolecules through the plasma membrane and endosomal barriers remains a major challenge.

14 Thus, phagosomal/endosomal binding of peptides locally generated by prote

15 Inhibition of the endosomal cholesterol exporter NPC1 greatly reduced sphi

16 553Cys) mutation in CLCN6, encoding the late endosomal Cl(-)/H(+)-exchanger ClC-6.

17 cellular origin that derive either from the endosomal compartment (exosomes) or as a result of shedd

18 nct compartments related to its function: an endosomal compartment and a DCV biogenesis-related compa

19 an impairment of endocytosis and an enlarged endosomal compartment in neurons with a decrease in spon

20 ion of PI(3)P phosphoinositide and the early endosomal compartment in TBSV replication.

21 enrichment of proteins that function in the endosomal compartment of cells responsible for vesicle f

22 ier (i.e. the vasculature, cell membrane, or endosomal compartment), but fail to deliver an adequate

23 gh the control of cholesterol content at the endosomal compartment/MVBs.

24 ion of PI3Kalpha with activated receptors at endosomal compartments along microtubules.

25 sis, attesting a reducing environment in the endosomal compartments and the dynamics of TfR1 traffick

26 Antigens directed to endosomal compartments are degraded, and the peptides ar

27 Smooth endoplasmic reticulum (SER) and endosomal compartments could provide local stores of mem

28 hoinositide levels correlate with changes in endosomal compartments that have previously been associa

29 e Rab6-mediated trafficking pathway contains endosomal compartments that share features with the Mtb

30 not disrupt localization of mCherry-RavD to endosomal compartments, suggesting that RavD's interacti

31 dogenous tau, which accumulates in lysosomal/endosomal compartments.

32 ow-derived DCs, Dectin-1 is redistributed to endosomal compartments.

33 In species within the PM, Golgi complex, and endosomal compartments.

34 owing receptor binding, IFN-I is siloed into endosomal compartments.

35 L1 that share common roles in transport from endosomal compartments.

36 ves virion budding, assisted by the cellular endosomal complex required for transport (ESCRT) protein

37 conformation of pUL51 resembles the cellular endosomal complex required for transport (ESCRT)-III com

38 e of nuclear envelope integrity requires the EndoSomal Complexes Required for Transport (ESCRT) prote

39 Surprisingly, endosomal curvature does not grossly alter fusion kineti

40 ab regulation of SNX16 assembly controls the endosomal distribution and signaling activities of recep

41 TRX-1 also mediates endosomal disulfide reduction in human cells.

42 Our studies reveal that endosomal DNA degradation occurs mainly in lysosomes and

43 Moreover, the endosomal DNA sensor TLR9 promotes anti-dsDNA responses

44 ulfed by innate immune cells and digested by endosomal DNase II to generate an immune response.

45 ocalization but were located on the distinct endosomal domains.

46 rticle delivery strategy to evaluate whether endosomal DOPr might be a therapeutic target for pain.

47 These findings directly link endosomal dysfunction to RV de-repression in an FTD-ALS

48 nvolve the F-box adaptor protein Dia2 and an endosomal effector protein, the phosphatidylinositol 3-k

49 ependent basket structure for an alternative endosomal egress.

50 tforms for delivery into cells is limited by endosomal entrapment of delivered protein cargo with con

51 We further show that CD74 p41 can block the endosomal entry pathway of coronaviruses, including SARS

52 standing prefusion-spike mechanics governing endosomal entry; we suggest that the low pH all-down con

53 In the acidic endosomal environment, the nanotransformer-based vaccine

54 core for release in the acidic and reducing endosomal environment.

55 The conjugate contains an endosomal enzyme-responsive linker enabling degradation

56 with cell membranes, histidine to facilitate endosomal escape and cysteine for stability and controll

57 Only those exhibiting early endosomal escape and high pH of fusion were inhibited vi

58 By contrast, strains exhibiting later endosomal escape and lower fusion pH proved resistant to

59 attributed to its pH-controlled release and endosomal escape capabilities due to the proton sponge e

60 AB toxins with built-in cell targeting and endosomal escape mechanisms are attractive intracellular

61 poly(I:C), and, when overexpressed, enhances endosomal escape of poly(I:C) in vitro.

62 In this review, we briefly discuss endosomal escape strategies and review the strategy of c

63 Therefore, LNP uptake, endosomal escape, and mRNA translation with and without

64 l interior by passive diffusion, endocytosis/endosomal escape, or other mechanisms.

65 driven by intracellular re-distribution and endosomal escape.

66 interactions which enable designs to improve endosomal escape.

67 ll contained in vesicles with no evidence of endosomal escape.

68 de endosomal rupture as the primary means of endosomal escape.

69 st that this environment is prerequisite for endosomal escape.

70 dicating the influence of peptide design for endosomal escape.

71 m cancer cells is increased relative to late endosomal exosomes by reducing growth regulatory Akt/mec

72 n actin nucleation promoting factor), excess endosomal F-actin and trapping of internalized receptors

73 Additionally, Alix is an early acting endosomal factor involved in HIV-1 budding from the cell

74 quitinating enzyme (DUB) regulating the post-endosomal fate of human NHE3.

75 icant additional insight into the process of endosomal fission and connecting the sorting and fission

76 ecrease in CAV1 protein abundance as well as endosomal fission defects resulting from pathogenic SPG8

77 g that EHD1 depletion impairs SNX17-mediated endosomal fission.

78 c regulatory domain impair NHE6 activity and endosomal function are poorly understood.

79 Given the putative role of NHE6 in early endosomal function, we examined Rab GTPase expression in

80 y of purified PI3KC3-C1, and is required for endosomal generation of phosphatidylinositol-3-phosphate

81 In tumors with low Beclin 1 expression, endosomal HRS recruitment was diminished and receptor fu

82 ng the importance of BLOC-2/exocyst-mediated endosomal input during VWF maturation.

83 osomes, resulting in immature WPBs that lack endosomal input.

84 acellular vesicles (EVs) that originate from endosomal intraluminal vesicles (ILVs), have emerged as

85 quus caballus at 3.2 angstrom resolution, an endosomal isoform highly expressed in the brain and asso

86 el in which cholesterol abundance influences endosomal K(+) levels and, consequently, the efficiency

87 ol homeostasis coordinating Rab7 activation, endosomal LDL trafficking and NPC1-dependent lysosomal c

88 vere defects in late endosome morphology and endosomal LDL trafficking, resulting in cellular cholest

89 sterified cholesterol and lipids in the late endosomal (LE) and lysosomal (Ly) compartments.

90 ot retriever, is required to maintain normal endosomal levels of phosphatidylinositol-3-phosphate (PI

91 d ARM peptide possess the ability to disrupt endosomal-like membranes, whereas VLP lacking the ARM se

92 s of SK2 activity and S1P in AD to perturbed endosomal lipid metabolism.

93 Impaired ALIX function leads to altered endosomal localization and increased accumulation of ABA

94 in development, we detected that besides the endosomal localization it also targets neuronal nuclei,

95 Finally, we followed the endosomal localization of EGFR in the FCs.

96 ally, Vps8 overexpression abolishes the late endosomal localization of HOPS-specific Vps41/Lt and pre

97 n of Rab5aS34N (inactive mutant) reduced the endosomal localization of TbetaRII in HSCs compared to t

98 including dysregulation of genes within the endosomal-lysosomal and autophagy pathways, cytoskeletal

99 al cysteine hydrolase primarily found in the endosomal-lysosomal compartment of innate and adaptive i

100 , including GABAergic neurotransmission, the endosomal-lysosomal pathway and autophagy, and neurotrop

101 b is one of several GTPases essential to the endosomal-lysosomal pathway and is implicated in protein

102 he deleterious effects of dysfunction of the endosomal-lysosomal system in neurodegenerative disorder

103 d plays critical roles in the control of the endosomal-lysosomal system.

104 activity, localization, and function in the endosomal-lysosomal system.

105 -7a (Rab7a) serves as a key organizer of the endosomal-lysosomal system.

106 unnel that mediates cholesterol flux in late endosomal/lysosomal (LE/Ly) compartments.

107 Here, we identified the late endosomal/lysosomal adaptor MAPK and mTOR activator (LAM

108 Instead, H84T is internalized into the late endosomal/lysosomal compartment and inhibits virus-endos

109 r studies show that DSTYK is located in late endosomal/lysosomal compartments and is involved in the

110 logical changes: vacuolation with disordered endosomal/lysosomal compartments and-common to sphingoli

111 t the fraction of FAP-EGFR located in acidic endosomal/lysosomal compartments.

112 ur results provide a guide to select CPP for endosomal/lysosomal delivery and a basis for developing

113 of GLUT8 at a major metabolic hub (the late endosomal/lysosomal interface) and its regulated cleavag

114 been reported to also interact with the late endosomal/lysosomal membrane glycoprotein CLN3 (ceroid l

115 ize and degrade alpha-syn aggregates via the endosomal/lysosomal pathway.

116 The results suggest that the multivesicular endosomal machinery and the novel player TFG have import

117 points, Axin and dsh colocalized with early endosomal marker Rab5, and new microtubule growth initia

118 ivered pp71 was found to be colocalized with endosomal markers and was not associated with the seven

119 discoideum and macrophages and reduced early endosomal markers in macrophages.

120 The pH drop that accompanies endosomal maturation, often in conjunction with proteoly

121 h or width), which mechanically disrupts the endosomal membrane and directly delivers the antigenic p

122 , triggers viral proteins to insert into the endosomal membrane and drive fusion.

123 es, which restricts fusion with the limiting endosomal membrane and prevents cellular infection.

124 The assay preserved endosomal membrane asymmetry and protein composition, pr

125 This result suggests that endosomal membrane curvature is not a key permissive fea

126 entry via receptor-mediated endocytosis and endosomal membrane fusion.

127 assays allow us to propose a model for PCV2-endosomal membrane interaction wherein the ARM peptide e

128 tional fusion experiments of lipoplexes with endosomal membrane models show two distinct modes of tra

129 1 can transition between different actin and endosomal membrane tethered states.

130 des, which facilitate the penetration of the endosomal membrane to release transcriptionally active c

131 lex, as well as the lipid composition of the endosomal membrane, have a significant impact on fusion

132 rane receptors, localized at the cellular or endosomal membrane, trigger inflammatory processes throu

133 rf6 depletion promotes the loss of RhoB from endosomal membranes and leads to RhoB degradation throug

134 review emerging modes of GPCR signaling via endosomal membranes and the physiological implications o

135 requires Tollip interaction with ubiquitin, endosomal membranes and Tom1 to ensure their trafficking

136 s to GP2 domain-mediated fusion of viral and endosomal membranes is not known.

137 plex is docked to the cytoplasmic surface of endosomal membranes, it phosphorylates its substrate lip

138 ), led to recruitment of cytoplasmic EHD1 to endosomal membranes.

139 HA2, which may bridge between the viral and endosomal membranes.

140 earrangements that drive fusion of viral and endosomal membranes.

141 th PI(3)P is not necessary to anchor RavD to endosomal membranes.

142 l entry, with Gc driving fusion of viral and endosomal membranes.

143 Blocking endocytosis or endosomal Met/beta1-integrin/FAK signaling profoundly in

144 VPS4A function was also required for normal endosomal morphology and IST1 localization in iPSC-deriv

145 ve from intraluminal vesicles formed in late endosomal multivesicular bodies (MVBs).

146 Rab11, generated in Rab11-positive recycling endosomal MVBs.

147 he mechanisms of cargo transport through the endosomal network are poorly understood.

148 Specifically, niclosamide-induced endosomal neutralization not only prevents viral RNA rep

149 We found that niclosamide-induced endosomal neutralization prevented E glycoprotein confor

150 s that ratiometrically report phagosomal and endosomal NO, and can be molecularly programmed to displ

151 artments which appear to lack characteristic endosomal or lysosomal markers.

152 Exosomes, extracellular vesicles (EVs) of endosomal origin, emerge as master regulators of cell-to

153 ADAM10 on exosomes-extracellular vesicles of endosomal origin.

154 s earlier than our previously reported brain endosomal pathway changes, arguing that an apolipoprotei

155 Our results indicate that the endosomal pathway is required for the signaling cascade

156 TLR-mediated sensing of nucleic acids via endosomal pathways has been studied and documented in de

157 virus entry, which can occur through low-pH-endosomal pathways.

158 f interferon genes and antigen delivery upon endosomal pH activation, leading to T cell-mediated anti

159 hat an intermediate expanded conformation at endosomal pH could relax the frustration, allowing histi

160 fusion with host membranes triggered by low endosomal pH is an important route of entry for PRV.IMPO

161 hat Orai1-SNPs escape late endosomes through endosomal pH regulation of interaction between the chann

162 ) require a particularly tight regulation of endosomal pH to ensure strong type I IFN secretion exclu

163 ron microscopy structures-at serological and endosomal pH-delineating spike recognition of up to thre

164 To translate this finding, we develop endosomal pH-responsive nanoparticles (NPs) which delive

165 activates the channel in response to the low endosomal pH.

166 of fusion were inhibited via a reduction in endosomal pH.

167 lin-1, small-molecule inhibitors of the main endosomal phosphatidylinositol-3-phosphate/phosphatidyli

168 These results reveal a late endosomal PI4P-PI(4,5)P(2) -dependent regulatory loop th

169 tion of IRAP in 3T3-L1 adipocytes shifts the endosomal pool of Glut4 to more acidic endosomes, but do

170 Here we find that, among the endosomal pools, Rab7-positive compartments possess the

171 on myeloid cells 2, CD163; P < 0.05-0.0001), endosomal processing (P < 0.05-0.0001), and ~80% increas

172 Biochemical assays quantify endosomal processing but lack organelle-specific informa

173 rt interfering RNA screens, we find that the endosomal protein sorting nexin 5 (SNX5)(3,4) is essenti

174 dosomes have emerged as important players in endosomal protein sorting, dynamics and motility.

175 IFITM3) has previously been identified as an endosomal protein that blocks viral infection(1-3).

176 nd these cellular factors were essential for endosomal protein trafficking and formation of the VS an

177 by mass spectrometry, and revealed that many endosomal proteins interacted with Lrp6 within 5 min of

178 Both endosomal proteolysis of EBOV GP and binding of mAb FVM0

179 Ligand-induced monoubiquitination and endosomal puncta of BIK1 exhibit spatial and temporal dy

180 rs the minimal feed-forward machinery of the endosomal Rab cascade and a novel regulatory mechanism c

181 es with the RAB7-GAP TBC1D5 to restrict late endosomal RAB7 into microdomains that are spatially sepa

182 arrestin-mediated MAPK activation as well as endosomal receptor-beta-arrestin complex stabilization i

183 as conventional dendritic cells (DC) exploit endosomal recognition by intracellular TLRs.

184 Beclin 1 promoted endosomal recruitment of hepatocyte growth factor tyrosi

185 fication of retromer, a master controller of endosomal recycling [4-6], as a key component regulating

186 Endosomal recycling maintains the cell surface abundance

187 Here, we identify a sorting motif for endosomal recycling of cargoes, including the cation-ind

188 argo adaptor are important components in the endosomal recycling of Flamingo and Strabismus back to t

189 ke cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R.

190 through clathrin-mediated endocytosis (CME), endosomal recycling, or degradation.

191 ce relies on retromer, a master conductor of endosomal recycling.

192 ablished, certain specific aspects, like the endosomal redox state, remain less characterized.

193 what factors contribute to the efficiency of endosomal release.

194 becomes trapped on endosomes coated with the endosomal retrieval machinery retromer.

195 Loss of TMEM16K function led to impaired endosomal retrograde transport and neuromuscular functio

196 For example, mutations in the endosomal retromer complex are implicated in Alzheimer's

197 complementary cell-based assays, we exclude endosomal rupture as the primary means of endosomal esca

198 and amphipathicity-based mechanisms used for endosomal SARS-CoV-2 restriction.

199 Endosomal sequestration of lipid-based nanoparticles (LN

200 DOPr endocytosis and endosomal signaling by protein kinase C (PKC) and extrac

201 Because Rabs mediate TrkB endosomal signalling, we evaluated TrkB phosphorylation

202 231 NMDAR blockade results in an increase in endosomal size and decrease in number.

203 ning has identified numerous variants of the endosomal solute carrier family 9 member A6 (SLC9A6)/(Na

204 ylinositol 4 kinase (PI4KII)-dependent early endosomal sorting and accumulation of phosphatidylinosit

205 licates TMEM16K lipid scrambling activity in endosomal sorting at these sites.

206 lation, target cell, and the function of the endosomal sorting complex required for transport (ESCRT)

207 The endosomal sorting complex required for transport (ESCRT)

208 The endosomal sorting complex required for transport (ESCRT)

209 enesis machinery through upregulation of the endosomal sorting complex required for transport (ESCRT)

210 In mammalian cell lines, the endosomal sorting complex required for transport (ESCRT)

211 s to MMP14 and to Tsg101, a component of the endosomal sorting complex required for transport (ESCRT)

212 These proteins are members of the endosomal sorting complex required for transport (ESCRT)

213 The endosomal sorting complex required for transport (ESCRT)

214 repair response by enabling assembly of the endosomal sorting complex required for transport (ESCRT)

215 kinase activity is required for formation of endosomal sorting complex required for transport III fil

216 controlling ubiquitination of the ESCRT-III (endosomal sorting complex required for transport III) co

217 t to involve the late-acting cellular ESCRT (endosomal sorting complex required for transport) compon

218 ia interaction with components of the ESCRT (endosomal sorting complex required for transport) pathwa

219 The endosomal sorting complex required for transport-III (ES

220 The endosomal sorting complexes required for transport (ESCR

221 tations in CHMP2B, encoding a protein in the endosomal sorting complexes required for transport (ESCR

222 restingly, hyperactive Vps34 does not affect endosomal sorting complexes required for transport (ESCR

223 The endosomal sorting complexes required for transport (ESCR

224 The endosomal sorting complexes required for transport (ESCR

225 rt of the lysosomal degradation pathway, the endosomal sorting complexes required for transport (ESCR

226 cent influenza virus, which does not use the endosomal sorting complexes required for transport machi

227 eformation of sealed nuclei requires ESCRTs (endosomal sorting complexes required for transport) and

228 al vesicles accumulate over time, use ESCRT (endosomal sorting complexes required for transport) mach

229 In vitro evidence implicates BIN1 in endosomal sorting of BACE1 and Abeta generation in neuro

230 clinically relevant platforms for regulating endosomal sorting.

231 PC1 or Gramd1b that is dependent on the late endosomal sterol-binding protein STARD3, likely underlyi

232 Proband-derived fibroblasts had enlarged endosomal structures with abnormal accumulation of the E

233 s such as Toll-like receptor 9 (TLR9) on the endosomal surface of immune cells, in particular neutrop

234 mate receptors controls the structure of the endosomal system and suggest that aberrations in NMDAR-r

235 ve been extensively studied, the role of the endosomal system has been far less characterized.

236 d a beneficial role for EVs in AD, where the endosomal system in vulnerable neurons is compromised, c

237 sorting and trafficking of VAMP2 within the endosomal system is not well understood.

238 lgi-derived SGs requires trafficking via the endosomal system, similar to mechanisms employed by LROs

239 dapted to bulk membrane trafficking from the endosomal system.

240 tically distinct retrieval pathways from the endosomal system: a plasma membrane recycling pathway th

241 biogenesis of organelles from the lysosomal-endosomal-system.

242 sly unappreciated function of IRAP-dependent endosomal TCR signalling in T cell activation.

243 data support a function for LRBA in limiting endosomal TLR signaling and consequent intestinal inflam

244 une-modulating regulatory cross-talk between endosomal TLR signaling and cytosolic NLR activation wit

245 PLSCR1, a phospholipid scramblase mediating endosomal TLR-9 translocation.

246 Endosomal TLR3 in hPDL cells was observed by immunocytoc

247 Inappropriate activation of endosomal TLR7 and TLR8 occurs in several autoimmune dis

248 Although endosomal TLR7 recognizes single-stranded RNAs, their en

249 endosomes in recipient cells and to activate endosomal TLR7.

250 nt R848 and the RNA adjuvant PUUC, targeting endosomal TLR7s and cytoplasmic RLRs respectively, when

251 Rather, histone-bound DNA stimulated endosomal Tlr9-dependent responses in a Clec2d-dependent

252 nses after the recognition of foreign DNA by endosomal TLR9.

253 these studies reveal that R-DOTAP stimulates endosomal TLRs, resulting in a Myd88-dependent productio

254 and dendritic cells as well as expression of endosomal TLRs, TLR7 and TLR9, that modulate production

255 a chaperone protein involved in signaling by endosomal TLRs.

256 ity and reveal a major contribution of pDCs, endosomal Toll-like receptors (TLRs), and IFN-I to this

257 signaling pathways, including those through endosomal Toll-like receptors (TLRs), Fc gamma receptors

258 esponse in recipient cells via activation of endosomal Toll-like receptors.

259 how cellular restriction factors and altered endosomal trafficking affect viral membrane fusion.IMPOR

260 n beta-arrestin2 and differentially impacted endosomal trafficking and MAPK signaling.

261 ART encodes for Spartin, a protein linked to endosomal trafficking and mitochondrial membrane potenti

262 ausing mutations are known to be involved in endosomal trafficking and RNA regulation.

263 Endosomal trafficking and subsequent recycling or degrad

264 MR1 molecules from the cell surface through endosomal trafficking compartments to the TGN.

265 , with several of them linked to retromer or endosomal trafficking dysfunction.

266 BMP6 controls AMOT internalization and endosomal trafficking in epithelial cells.

267 Fludioxonil appears to impair endosomal trafficking in the fungal cells.

268 ngs suggest that MCTP-SNARE complex-mediated endosomal trafficking is essential for the export of flo

269 portantly, Tollip regulates Parkin-dependent endosomal trafficking of a discrete subset of mitochondr

270 ecently demonstrated that RhoJ regulates the endosomal trafficking of podocalyxin during angiogenesis

271 Examples on endosomal trafficking or increase of tension at mitochon

272 6, a small GTPase that regulates a number of endosomal trafficking pathways including retrograde tran

273 In addition, we identify an endosomal trafficking protein, Syntaxin 4, which is spec

274 Several Notch endosomal trafficking regulators differentially regulate

275 e components via retrograde dynein-dependent endosomal trafficking that restricts plasma membrane gro

276 cluding cytokine signaling, mRNA processing, endosomal trafficking, and protein metabolism.

277 genes causing NCL with retromer function and endosomal trafficking, review the recent evidence linkin

278 matin-associated degradation, autophagy, and endosomal trafficking.

279 autophagosome, and Complex II is crucial for endosomal trafficking.

280 ily related to kinase signaling pathways and endosomal trafficking.

281 a factor), a protein encoding a regulator of endosomal trafficking.

282 the pH change that is associated with virus endosomal trafficking.

283 are a biological pathway, retromer-dependent endosomal trafficking.

284 protein (EXC-9/CRIP1) that regulates apical endosomal trafficking.

285 We identify endosomal transport as a major functional cluster of TME

286 of the matrix metalloproteinase MT1-MMP via endosomal transport by mechanisms that are not known.

287 for targets within endosomes because of the endosomal transport mechanisms of many nanomedicines wit

288 However, endosomal trapping and low immunogenicity of tumour anti

289 ense mutations in strumpellin did not rescue endosomal tubulation defects, reduction in CAV1 protein

290 whose effectors modify the vacuole, driving endosomal tubulation.

291 ed for formation of stable PI4KII-containing endosomal tubules associated with this process.

292 Tom1 transports endosomal ubiquitinated proteins that are targeted for d

293 viral RNA in the exosome lumen, but not the endosomal uncoating of HAV particles contained in the ex

294 junction maintenance and signaling often via endosomal uptake of polarity proteins at tight junctions

295 leus, targeting them for degradation via the endosomal/vacuolar RSL1-dependent pathway or 26S proteas

296 rexpression of VPS4A mutants caused enlarged endosomal vacuoles resembling those induced by expressio

297 cellular processes including cell division, endosomal vesicle trafficking, and viral budding.

298 l does not recognize target cells or disrupt endosomal vesicles in its unmodified state, but can inco

299 ex, while maintaining CD3zeta signalling, in endosomal vesicles that contain the insulin responsive a

300 golgin-97/245 and the WASH/FAM21 complex on endosomal vesicles.