ライフサイエンスコーパス: endothelium

1 ignal to vasodilatory target coupling in the endothelium.

2 duced breaks in cortical and hippocampal BBB endothelium.

3 etween intravascular blood monocytes and the endothelium.

4 ewal and evolution of the alveolar capillary endothelium.

5 essing from the epithelium layer towards the endothelium.

6 rythrocytes without adhering to the vascular endothelium.

7 3 modulates BMP and TGFbeta signaling in the endothelium.

8 nteraction of immune cells with the vascular endothelium.

9 or complex disease is manifested through the endothelium.

10 ngeal ECM microenvironment, extrinsic to the endothelium.

11 or SP3 and MAZ in the formation of hemogenic endothelium.

12 copy images in all corneal layers except the endothelium.

13 ranscription factor complex in the pulmonary endothelium.

14 eutic treatments to repair the damaged brain endothelium.

15 is imperative for proper functioning of the endothelium.

16 sed the effects of P. gingivalis OMVs on the endothelium.

17 ickle red blood cells (RBCs) to the vascular endothelium.

18 IP(3)-evoked local Ca(2+) release in intact endothelium.

19 d mainly intravascularly and at the vascular endothelium.

20 oof endothelium (ARE)s, excluding non-aortic endothelium.

21 they are protected from therapy by vascular endothelium.

22 ivation, leading to neutrophil attachment to endothelium.

23 ll types such as smooth muscle, neurons, and endothelium.

24 ruitment of endothelial cells from uninjured endothelium.

25 ortunity to control drug delivery across the endothelium.

26 y influencing the hemostatic capacity of the endothelium.

27 axis regulates neutrophil firm attachment to endothelium.

28 at extend along the abluminal surface of the endothelium.

29 in cardiac mesoderm, distinct from vascular endothelium.

30 barrier function in HKSA-challenged vascular endothelium.

31 undergo prolonged migration on the inflamed endothelium.

32 nt cells that patrol the luminal side of the endothelium.

33 cific cells, such as hematopoietic cells and endothelium.

34 eration of multilineage HSPCs from hemogenic endothelium.

35 , but only Kir6.1 was expressed in lymphatic endothelium.

36 ises from smooth muscle cells (SMCs) and not endothelium.

37 ctural changes of all corneal layers but the endothelium.

38 m and cardiac contractile genes in the heart endothelium.

39 ulation decreased miR-1 levels in human lung endothelium.

40 r PK for corneal pathologies with functional endothelium.

41 tional levels, including (1) adhesion to the endothelium, (2) migration, and (3) survival.

42 1 expression was upregulated in the arterial endothelium 3 days after ligation before any detectable

43 CX degradation, leading to CTC homing to the endothelium, a first step in secondary tumor formation.

44 However, such organs contain host endothelium, a source of immune rejection.

45 ediated by selectins (expressed by activated endothelium, activated platelets, and leukocytes) bindin

46 ts of long proteoglycans protruding from the endothelium, acts as a regulator of inflammation by prev

47 We found that choroidal endothelium adjacent to the RPE expresses high levels of

48 tatic BEC turnover and to neogenesis of high endothelium after immunization.

49 oprone gene expression in the mouse arterial endothelium after ligation (n=6), or in cultured human u

50 molecules covers the luminal surface of the endothelium along the entire vascular tree, mostly compr

51 sponse is postulated to be controlled by the endothelium, although the underlying molecular mechanism

52 may be an effective strategy to protect the endothelium, although there is no consensus about the be

53 report that mural cells, which surround the endothelium and are critical for blood-brain-barrier int

54 itochondrial biogenesis and function in lung endothelium and attenuation of ALI.

55 may originate from both pre-existing normal endothelium and cancer-derived cells.

56 such as synaptic vesicle genes in the brain endothelium and cardiac contractile genes in the heart e

57 We evaluated the impact of Lp(a) on the endothelium and describe that Lp(a), through its oxidize

58 k between the Notch pathway and Kmt2d during endothelium and endocardium patterning and shows that ph

59 ons analyzed were embryonic day 10.5 (E10.5) endothelium and hemogenic endothelium from the major art

60 in platelet adherence to the cerebrovascular endothelium and highlight the ability of synthetic EVs t

61 ung development involving Cyp26b1-expressing endothelium and identifies a novel RA modulator in lung

62 es the trafficking of CD57(+) CD4 T cells to endothelium and may therefore be important in linking th

63 the endocrine placenta targets the maternal endothelium and multiple organs to adjust metabolism for

64 Glomerular endothelium and non-classical monocytes overexpressed a

65 tiligand receptor, which is expressed on the endothelium and other cell types, including epithelial c

66 , a parallel channel lined by human vascular endothelium and perfused with culture medium, and a poro

67 diminution of tight junctions (TJ) in brain endothelium and pericyte coverage and inflammation in ce

68 unction through regeneration of a functional endothelium and re-engagement of endothelial junctions.

69 Fgfbp1 is expressed in the CNS endothelium and secreted into the vascular basement memb

70 ) channels are also located within vascular (endothelium and smooth muscle) and muscle (cardiac and s

71 o studies of two critical tissue components: endothelium and stroma.

72 into normal rats, MPs immediately adhered to endothelium and subsequently mediated leukocyte adhesion

73 d our understanding of PPARbeta/delta in the endothelium and support the targeting of PPARbeta/delta

74 tools for studying the emergence of coronary endothelium and targeting sprouting coronary vessels (bu

75 ivated integrin alpha5beta1 signaling in the endothelium and triggered fatty acid transport via CD36

76 rst, a hemogenic progenitor buds up from the endothelium and undergoes division forming the monoclona

77 iezo controls Klf2 and Notch activity in the endothelium and Yap1 localization in the smooth muscle p

78 l deflections of a cell monolayer (i.e., the endothelium) and require localized changes in monolayer

79 lular and molecular pathways of the vascular endothelium, and influencing fistula maturation and form

80 elial activation, tumor cell adhesion to the endothelium, and recruitment of metastasis-promoting mon

81 ocytosis, degranulation, ability to harm the endothelium, and responses to type I interferon (IFN) st

82 direction of neutrophil migration along the endothelium, and their interaction may play an important

83 bility and structural disorganization of the endothelium, and we identify the distinct secretion of I

84 mplex; downregulated these genes in the lung endothelium; and reduced surface P-selectin levels in IL

85 Hyposialylated IgG and FcgammaRIIB in endothelium are critically involved in obesity-induced h

86 n of cancer cells through blood/lymph vessel endothelium are essential steps during metastasis.

87 ing, adhesion, and transmigration across the endothelium are mediated by specific interactions betwee

88 s between different monocyte subsets and the endothelium are regulated.

89 reporter line to isolate HE and aortic roof endothelium (ARE)s, excluding non-aortic endothelium.

90 ata suggest the central nervous system (CNS) endothelium as a target to treat respiratory and affecti

91 rotein ratio within the muscle microvascular endothelium as virtually supervised home-based MICT and

92 le cells and decreased monocytes adhesion to endothelium, as well as reducing TNF-alpha, IL-1beta, CO

93 tokines were higher in TCMR, while activated endothelium-associated transcripts were higher in CAMR t

94 Deletion of miR-15a/16-1 cluster in endothelium attenuates post-stroke brain infarction and

95 The printed constructs demonstrate endothelium barrier function and spontaneous beating of

96 compromise the integrity of the blood-brain endothelium (BBE).

97 in the SHF and contribute to pharyngeal arch endothelium between E7.5 and E9.5.

98 However, in plasma and lung endothelium, but not smooth muscle or adventitia, miR-21

99 , our findings show that Lp(a) activates the endothelium by enhancing PFKFB3-mediated glycolysis, lea

100 ein 1 (NS1) alters glycosaminoglycans on the endothelium, causing hyperpermeability in vitro and vasc

101 Corneal endothelium (CE) is a monolayer of mitochondria-rich cel

102 cytotrophoblast cell line, HTR-8/SVneo, and endothelium cells.

103 How lung epithelium and endothelium co-develop to maintain structural integrity

104 nd corneal Scheimpflug imaging, the Descemet endothelium complex (DEC) was retrieved during DM endoth

105 d cytotoxins during infection, (2) pulmonary endothelium contributes to innate immunity by generating

106 agic shock results in systemic injury to the endothelium contributing to post-shock morbidity and mor

107 The toxin also targets DARC on the endothelium, contributing to the lethality observed duri

108 Epithelium-endothelium cross-talk is further studied by exposing pr

109 eyes appears relatively safe to the corneal endothelium, demonstrating a small and nonsignificant de

110 The extract possesses the ability to induce endothelium dependent vasodilation, which is dependent o

111 The vasorelaxation properties seemed to be endothelium dependent, as well as nitric oxide (NO) and

112 contraction amplifies vasodilatation to the endothelium-dependent agonist ACh, whereas there was no

113 moglobin (Hb) may impact the transduction of endothelium-dependent and nitric oxide (NO)-mediated vas

114 y vascular endothelial dysfunction (impaired endothelium-dependent dilatation, EDD) and aortic stiffe

115 Endothelium-dependent dilation was blunted in MDD and me

116 The response to endothelium-dependent microvascular vasodilation was gre

117 nder normal conditions through constraint of endothelium-dependent NO-mediated vasodilatation in heal

118 Endothelium-dependent relaxation (EDR) is an initial key

119 pid accumulation in the liver; and decreased endothelium-dependent relaxation of aorta.

120 arteries and the role played by caveolae in endothelium-dependent relaxation.

121 ae structure and integrity are essential for endothelium-dependent relaxation.

122 a-arterial infusion of ACh or ATP to augment endothelium-dependent signalling during exercise attenua

123 dy, we tested the hypothesis that increasing endothelium-dependent signalling during exercise in olde

124 However, augmentation of endothelium-dependent signalling via infusion of ACh or

125 exercise + infusion of ACh or ATP to augment endothelium-dependent signalling.

126 monstrate that, given a sufficient stimulus, endothelium-dependent sympatholysis remains intact in ol

127 Almonds, compared with control, increased endothelium-dependent vasodilation (mean difference 4.1%

128 ng-severe systolic hypertension and impaired endothelium-dependent vasodilation due to uncoupled NO s

129 Impaired endothelium-dependent vasodilation is a hallmark of obes

130 One mechanistic hypothesis involves impaired endothelium-dependent vasodilation through reactive oxyg

131 n but did not ameliorate the response to the endothelium-dependent vasodilator acetylcholine.

132 alpha(1) -agonist) during (i) infusion of an endothelium-dependent vasodilator alone (Protocol 1: ACh

133 t K(IR) channels function as 'amplifiers' of endothelium-dependent vasodilators.

134 In young adults, increasing endothelium-dependent vasodilatory signalling during mil

135 first in humans to demonstrate that specific endothelium-dependent vasodilatory signalling is amplifi

136 onses in resistance arteries and facilitates endothelium-dependent vasorelaxation only when CO(2)/HCO

137 However, the effects of the pulmonary endothelium-derived amyloid and tau proteins on brain fu

138 tem tissues obtained from animals exposed to endothelium-derived amyloids to assess these issues.

139 This finding suggests a role for other endothelium-derived mediators and/or for endothelium-ind

140 without nosocomial pneumonia indicated that endothelium-derived neurotoxins disrupted the postsynapt

141 n smooth muscle are thought to be targets of endothelium-derived nitric oxide.

142 t a positional identity that is regulated by endothelium-derived Notch signalling, and that this stro

143 The drivers of lymphatic endothelium development, SOX18 and PROX1, regulated diff

144 tion (EHT) is the process whereby haemogenic endothelium differentiates into haematopoietic stem and

145 aradigm with the discovery that the vascular endothelium does not just respond to exogenous cytokines

146 nal signaling between mammary epithelium and endothelium during homeostasis and pathogenesis.

147 hocytes as they traffic through the vascular endothelium during the immune response.

148 wall promotes inflammatory activation of the endothelium during vascular remodeling and atheroscleros

149 TNFalpha signaling in the vascular endothelium elicits multiple inflammatory responses that

150 that are lined with confluent epithelium and endothelium, embedded in a permeable ECM, and independen

151 s, including T-cell adhesion to blood vessel endothelium, endothelial activation, and T-cell transmig

152 xpression of the axon-guidance gene Slit2 in endothelium, establishing differential expression betwee

153 netic regulation of cldn5 expression and low endothelium expression of repressive cldn5-related trans

154 on Willebrand factor (VWF) released from the endothelium following photochemical injury in an endothe

155 ein-lipid interactions that occur at the sub-endothelium following vascular damage.

156 toxicity; (2) targeting the tumor-associated endothelium for specific delivery of the cargo to the tu

157 Patients with damaged or diseased endothelium from Fuchs endothelial dystrophy or pseudoph

158 chanism by which metformin protects vascular endothelium from SFA-induced ectopic lipid accumulation

159 Consistent with these findings, the endothelium from the IVC of xenograft-bearing animals re

160 c day 10.5 (E10.5) endothelium and hemogenic endothelium from the major arteries, an enriched populat

161 d uncover mechanisms by which the haemogenic endothelium generates early haematopoietic cells.

162 Diseased endothelium had increased expression of chemokine and al

163 Endothelium had intact structure in all cases.

164 The vascular endothelium has been discovered in the past several year

165 Targeted drug delivery to the endothelium has the potential to generate localized ther

166 n zebrafish emerge from the aortic hemogenic endothelium (HE) and migrate towards the caudal hematopo

167 ells (HSPCs), first specified from hemogenic endothelium (HE) in the ventral dorsal aorta (VDA), supp

168 stem cells are generated from the haemogenic endothelium (HE) located in the floor of the dorsal aort

169 fferentiation, including mesoderm, hemogenic endothelium (HE), and multipotent hematopoietic progenit

170 D57(+) CD4 T cells also express the vascular endothelium-homing receptor CX3CR1 and migrate toward CX

171 l transmigration through brain microvascular endothelium, (iii) detection of T cells, B cells, and bl

172 y microRNA known to be regulated in the lung endothelium in asthma models.

173 show the expression of LPL from the vascular endothelium in chickens.

174 stem cells (HSCs) develop from the hemogenic endothelium in cluster structures that protrude into the

175 c evidence to support a pivotal role for the endothelium in maintaining perfusion and microvascular p

176 We review functions of endothelium in our bodies, the development and uses of i

177 Angpt2-integrin alpha5beta1 signaling in SAT endothelium in regulating whole-body fat distribution fo

178 ation of monocytes through a confluent human endothelium in the absence of exogenous chemokines and a

179 enesis and suggest an important role for the endothelium in the etiology of aortic malformations.

180 her support the central role of the vascular endothelium in the pathobiology of PAH.

181 induce detectable HIF activity in the kidney endothelium, in vitro experiments implicated a humoral f

182 into a disposable cartridge in a tri-folded, endothelium-in configuration and delivered using bimanua

183 Tri-folded endothelium-in DMEK requires minimal time for graft unfo

184 and release of cytotoxic amyloids from lung endothelium, including beta amyloid, and tau.

185 her endothelium-derived mediators and/or for endothelium-independent adaptations with repeated RIPC.

186 Endothelium-independent dilation was likewise attenuated

187 ilatory response to sodium nitroprusside, an endothelium-independent nitric oxide donor.

188 diagnosed by assessing flow reserve with an endothelium-independent vasodilator like adenosine, but

189 , facial ectoderm, anterior heart field, and endothelium induces distinct spectra of phenotypes.

190 it participates in microvascular reactivity, endothelium interaction with blood constituents, and vas

191 rolase activity decreased platelet-leukocyte-endothelium interaction, transcription of pro-inflammato

192 ural crest-derived cells adjacent to the PAA endothelium into vascular smooth muscle cells.

193 The endothelium is an essential source of PDGFB in this proc

194 Regeneration of denuded or injured endothelium is an important component of vascular injury

195 During the immune response the vascular endothelium is constantly perturbed by biologically pote

196 ial migration (TEM) of leukocytes across the endothelium is critical for inflammation.

197 c-epigenetic signaling axis specified by the endothelium is essential for reprogramming interstitial

198 helium that lines the alveolus, the alveolar endothelium is made up of two intermingled cell types, w

199 The tissue-specific heterogeneity of the endothelium is maintained during systemic in vivo inflam

200 ds of tube-shunt implantation on the corneal endothelium is needed.

201 dothelial colony-forming cells, but a stable endothelium is noticeable at 4 weeks in vivo.

202 e show for the first time that IQGAP1 in the endothelium is required for efficient TEM in vivo.

203 monstrate that active KRAS expression in the endothelium is sufficient for brain arteriovenous malfor

204 We recently reported that peri-thrombus endothelium is targeted by HIT antibodies, but the bindi

205 (GCX), a carbohydrate-rich layer lining the endothelium, is crucial in vascular homeostasis.

206 In human endothelium isolated from donors with obesity or type 2

207 slational relevance was explored using human endothelium isolated from healthy donors and donors with

208 tracing studies demonstrate that the native endothelium itself serves as the primary source of endot

209 7C3-A20, including restoration of normal BBB endothelium length, increased brain capillary pericyte d

210 nsfers of a common blood substitute by their endothelium-lined channels (as reported by Novak et al.

211 itute through their reservoirs of medium and endothelium-lined vascular channels.

212 phosphorylating VE-cadherin in the activated endothelium, little is known of VE-PTP's role in the qui

213 s in the mouse lung, including macrovascular endothelium (maEC), microvascular endothelium (miECs), a

214 Whereas a healthy endothelium maintains physiological vascular functions,

215 of miR-15a/16-1 function in cerebrovascular endothelium may be a legitimate therapeutic approach for

216 gamma-dependent sensing of HCO(3)(-) adjusts endothelium-mediated vasorelaxation, microvascular perfu

217 rovascular endothelium (maEC), microvascular endothelium (miECs), and a new population we have termed

218 ells, rather than initially signaling to the endothelium, might exploit the autonomously forming gaps

219 sized that CysLT(2)R, via its actions on the endothelium, might regulate tumor growth.

220 s an in vitro BBB using a simulated cerebral endothelium monolayer formed by brain capillary endothel

221 eal specular microscopy revealed an abnormal endothelium morphology in the same eye with extensive pe

222 selectively identify a region of the corneal endothelium most affected by densely packed guttae.

223 e inflamed brain anti-VCAM/liposomes bind to endothelium, not to leukocytes.

224 on of MBL with beta2-GPI was observed on the endothelium of a biopsy specimen of a femoral artery fro

225 R-Ras is transiently up-regulated in the endothelium of high endothelial venules by the inflammat

226 ric oxide synthase (eNOS) are present in the endothelium of mesenteric and pulmonary arteries.

227 at IgG-specific processing occurs within the endothelium of the BBB, but any influence on transcytosi

228 uses T lymphocytes as a vehicle to reach the endothelium of the target organs in the absence or prese

229 the function of the miR-15a/16-1 cluster in endothelium on postischemic cerebral angiogenesis is not

230 rophils migrate along the activated vascular endothelium on which ligands, including intercellular ad

231 ated with Angpt2 protein localization in the endothelium or in the stromal extracellular matrix as we

232 Recruitment on inflamed human aortic endothelium or rVCAM-1 under fluid shear stress was asse

233 ut whether the channel localizes to vascular endothelium or smooth muscle is controversial and the di

234 emic stroke and other vascular diseases, the endothelium overexpresses specific markers, which can be

235 A 3D reconstruction of the endothelium overlying the plaque was also generated.

236 inning (P = .002), and was protective to the endothelium (P = .008).

237 oinflammatory and proadipogenic signature in endothelium, pericytes, and mesenchyme.

238 ore tissue blood supply and oxygenation; the endothelium plays a critical function in these intrinsic

239 ma and chronic rhinosinusitis (CRS), and the endothelium plays a key role in eosinophil trafficking.

240 a model of a leukocyte interacting with the endothelium predicts that the number of molecules within

241 Co-culture of neutrophils with resting endothelium prevented IgG-mediated increase of extracell

242 dominant negative mutant of BiP in the lung endothelium protected against LPS-induced lung inflammat

243 integrity of microvascular smooth muscle and endothelium recovers in parallel with myofibre regenerat

244 GLUT1 from the developing postnatal retinal endothelium reduces retinal EC proliferation and lowers

245 unohistochemistry showed enrichment in brain endothelium regardless of diagnosis and was localised to

246 ate coating of cells, including the vascular endothelium, regulates permeability, leukocyte traffic,

247 the bloodstream to tissues through a mature endothelium, remains unclear.

248 ate how the hypoxia response of the vascular endothelium remodels the lung pre-metastatic niche.

249 Analysis of the LSV endothelium revealed that activation of NF-kappaB occurr

250 umor vessels that lack S1PR1 in the vascular endothelium (S1pr1 ECKO) show excessive vascular sprouti

251 Mice with an inducible, endothelium-specific 12/15-lipoxygenase (12/15Lo) knocko

252 in renal function, we generated mice with an endothelium-specific and inducible deletion of hyalurona

253 Using transgenic mice, which enabled endothelium-specific and time-specific Fzd7 deletion, we

254 ls and aortic rings isolated from wild-type, endothelium-specific CNP(-/-), global natriuretic peptid

255 constriction was used in mice with inducible endothelium-specific deletion of leptin receptors (End.L

256 Analysis of a venous endothelium-specific enhancer for Ephb4 shows enriched b

257 Finally, we used MLECs from endothelium-specific enhancer of zeste homolog 2 (EZH2)

258 In contrast, lymphatic endothelium-specific expression of Kir6.1 GoF subunits h

259 rdiovascular HGPS pathology, we generated an endothelium-specific HGPS mouse model with selective end

260 We used endothelium-specific knockout mice and high-fat diet-fed

261 n the present study, we investigated whether endothelium-specific overexpression of CYP2J2 (tie2-CYP2

262 erfusion (I/R) injury in rats and found that endothelium-specific overexpression of CYP2J2 attenuated

263 Endothelium-specific overexpression of miR-1 reduced air

264 Endothelium-specific overexpression of miR-1 was achieve

265 edicted interacting cell types, particularly endothelium, stromal cells, and innate leukocytes.

266 cells prevents activation of human vascular endothelium, suggesting a potential role of the TLR2-res

267 cal flow assays, we found that an LPS-primed endothelium synergistically enhanced neutrophil TEM when

268 Endothelium-targeted deletion of the miR-15a/16-1 cluste

269 In the endothelium, TEM requires the coordination of membrane m

270 o induce a chemotactic signalling pathway in endothelium that drives intravasation and metastasis.

271 apyrase on the surface of leukocytes and the endothelium that inhibits intravascular inflammation and

272 plexes along VWF strings released by injured endothelium that might propagate the risk of thrombosis

273 c valves, which are lined with a specialized endothelium that originates from FLK1+ (a.k.a.

274 constraint on LYVE-1 clustering in lymphatic endothelium that tunes the receptor for selective engage

275 at express the cardinal marker for lymphatic endothelium-the lymphatic vessel hyaluronan receptor-1 (

276 eveal a mechanism by which SS sensitizes the endothelium to a cytokine-induced ER stress response to

277 rest and diapedesis across inflamed arterial endothelium to a greater extent in non-ST elevation MI c

278 To investigate the contribution of the endothelium to cardiovascular HGPS pathology, we generat

279 exploit the autonomously forming gaps in the endothelium to initiate transmigration.

280 EphB4 induces tumor cell repulsion from bone endothelium, translating in reduced spinal bone metastat

281 In the endothelium, VEGF mediates most of its angiogenic effect

282 have normal rolling and firm arrest on high endothelium venules (HEV), thereby attributing their ine

283 -classical monocytes surveyed the glomerular endothelium via lymphocyte function-associated antigen 1

284 Specificity for P7C3-A20 action on the endothelium was confirmed by protection of cultured huma

285 The images of the corneal endothelium was obtained by specular microscopy at least

286 The corneal endothelium was poorly visualized but no endothelial dam

287 inhibition was overcome for SLE-IgG when the endothelium was stimulated with TNF-alpha.

288 riptome of sonoselectively transfected brain endothelium was unaffected by the treatment.

289 IgG recycling and transcytosis in peripheral endothelium, was investigated by evaluating the transcyt

290 To evaluate the role of Cept1 in the endothelium, we engineered a conditional endothelial cel

291 eutrophil adhesion patterns to microvascular endothelium were not significantly different.

292 for anti-leukocyte antibodies is in fact the endothelium, which reframes our understanding of TRALI a

293 We report that the endothelium with high BMP activity due to the loss of BM

294 e ability of the cells to adhere to vascular endothelium with sufficient strength to overcome prevail

295 n generation was increased after priming the endothelium with TNF-alpha, our data suggests that this

296 provided a source of transplantable corneal endothelium, with a significant potential to challenge t

297 olled perfusion and formation of a confluent endothelium within 3-4 days in vitro with human endothel

298 SAR247799 activated S1P(1) on endothelium without causing receptor desensitization and

299 cilitates sonoselective gene delivery to the endothelium without MRI-detectable disruption of the BBB

300 e production of cytotoxic amyloids from lung endothelium, yet molecular mechanisms of host-pathogen i