ライフサイエンスコーパス: engineering

1 combination of ligand mutagenesis and ligand engineering.

2 emerging as a powerful mode of CRISPR-based engineering.

3 D is a promising material for cardiac tissue engineering.

4 atient phenotyping, drug testing, and tissue engineering.

5 ttery making, pharmaceuticals, cosmetics and engineering.

6 is method from fluid mechanics and hydraulic engineering.

7 lation of anisotropy, interface and topology engineering.

8 clic peptides for drug design or for protein engineering.

9 the fields of synthetic biology and protein engineering.

10 is for outlier detection in chemometrics and engineering.

11 ns ranging from nanotechnology to industrial engineering.

12 des data ideal for applications in metabolic engineering.

13 drug delivery, cell manipulation and tissue engineering.

14 data is a top priority in modern science and engineering.

15 ere suggested as future materials for tissue engineering.

16 tific research, practical manufacturing, and engineering.

17 s well as industrial applications of protein engineering.

18 yanines (PC) that was cationized by chemical engineering.

19 de deep tier, high-impact, complex ecosystem engineering.

20 search for ultrastrong metals via materials engineering.

21 rom microarrays and smart surfaces to tissue engineering.

22 de from standard output with no need for new engineering.

23 rdering has direct applications in metabolic engineering.

24 ve layer with comprehensive bandgap and film engineering.

25 t methods and their applications for peptide engineering.

26 of central importance in quantum science and engineering(1).

27 Rapid advances in cellular engineering(1,2) have positioned synthetic biology to ad

28 mpler leaf anatomical requirements make C(2) engineering a feasible approach to improve crops in the

29 ved quantum yields (QY) could be achieved by engineering a protein corona structure consisting of a r

30 as9-mediated genome editing in S. rosetta by engineering a selectable marker to enrich for edited cel

31 We describe a process for engineering a synthetic polymer nanoparticle (NP) that f

32 tional design, electrochemistry, and battery engineering, all to propel the Ca battery technology to

33 interpret the observations made for further engineering alloys with two-phase microstructures.

34 anded microstructures commonly occur in many engineering alloys, the analysis of stress and strain pa

35 y density functional theory calculations for engineering analogs of this class of fluorophores are of

36 tudy also demonstrates how relatively simple engineering analysis tools can revolutionize everyday he

37 lity and energy harvesting/storage to tissue engineering and additive manufacturing.

38 Via reservoir engineering and analogue quantum simulation techniques,

39 ucts for biosensors, tissue and regenerative engineering and bioelectronics.

40 ular construct based on a combinatorial nano-engineering and biomaterial encapsulation approach, coul

41 dy scaffolds, trastuzumab, used for antibody engineering and drug conjugation.

42 ntially patient-specific platform for tissue engineering and drug delivery.

43 Our work holds promise for dynamical strain engineering and dynamical strain-mediated control of lig

44 r suitability for applications in biomedical engineering and environmental remediation.

45 pectives Companion Paper: Integrating CRISPR Engineering and hiPSC-Derived 2D Disease Modeling System

46 Coupled with feature engineering and immunological context, researchers can i

47 of engineered macrophages, including genetic engineering and integration with biomaterials or drug de

48 to gender imbalances in science, technology, engineering and mathematics (STEM) fields, among other u

49 ic areas throughout the Science, Technology, Engineering and Mathematics (STEM) pipeline that perpetu

50 hich is central to a variety of domains from engineering and medicine to economics and social plannin

51 l EPSs have a promising future in biomedical engineering and medicine, especially as an alternative t

52 driven by technological advances in genetic engineering and metabolism as well as by the realization

53 nanomaterials make them ideal candidates for engineering and miniaturization of biosensors.

54 diated interactions as a tool for microbiome engineering and pathogen control.

55 Moderate to advanced engineering and programming skills are required to succe

56 The field of tissue engineering and regenerative medicine has made numerous

57 iomedical applications, especially in tissue engineering and regenerative medicine.

58 iven numerous pivotal advancements in tissue engineering and regenerative medicine.

59 Classical T4 phage engineering and several newly proposed methods are often

60 Here, the holistic engineering and systematic characterization of the impac

61 neration of mutant DNA sequences for protein engineering and the functional analysis of genetic varia

62 Together with breakthroughs in genome engineering and the various omics, organoid technology i

63 gene cassette), vector tropism (using capsid engineering) and the ability of the capsid and transgene

64 oftware engineering, socio-technical systems engineering, and a neurocognitive theory with abstract r

65 Here, combining live imaging, genome engineering, and acute chemical and genetic manipulation

66 etric-structure design, electronic-structure engineering, and applications in electrochemical energy

67 ochemistry, biomedical engineering, chemical engineering, and beyond.

68 ons in neural prosthetics, chip scale neural engineering, and extensions to different tissue and cell

69 ystallography, computer simulations, protein engineering, and functional assays to investigate the ro

70 apeutic development, tissue-specific genetic engineering, and genetic disease prediction will greatly

71 ations for public health and for the design, engineering, and management of urban green spaces.

72 e fields of material sciences, cell biology, engineering, and many other disciplines will gradually a

73 ng nanotechnology, microfluidics, electronic engineering, and material science have boosted a new era

74 e less than men in some science, technology, engineering, and math (STEM) fields.

75 ms, averaged across all science, technology, engineering, and mathematics (STEM) fields and courses.

76 their knowledge of biology, medicine, tissue engineering, and microtechnology to develop new effectiv

77 oprinting for in vitro tissue models, tissue engineering, and regenerative medicine are provided to f

78 tiple applications in the fields of antibody engineering, antibody humanization and CAR-T cell therap

79 ed material milieu with potential for future engineering applications and (5) proven feasibility and

80 They are important in many scientific and engineering applications due to their tunable physiochem

81 on for large-scale drug screening and tissue engineering applications.

82 yBac DNA transposon is used widely in genome engineering applications.

83 system useful for drug screening and tissue engineering applications.

84 for providing the insight of new innovative engineering applications.

85 ds are a promising platform for regenerative engineering applications.

86 es, but also adapting them to the context of engineering applications.

87 em for programmable DNA insertions in genome-engineering applications.

88 Our optogenetic engineering approach can be broadly applied to aid the m

89 Thus, the topological engineering approach enriches the toolbox for high-throu

90 production of bulk chemicals via a metabolic engineering approach it is necessary to better character

91 Here, we demonstrate a nanoscale interface-engineering approach that harnesses the large chemically

92 and minicircle DNA vectors- a promising cell engineering approach we previously reported (Journal of

93 pportunities one can exploit using a crystal engineering approach, for example, the design of novel d

94 Using a CRISPR/Cas9-based engineering approach, we genetically deleted five large

95 r substrate binding obtained using a crystal engineering approach.

96 ms to provide an updated overview of the key engineering approaches for better exploiting EVs in dise

97 re form, highlighting the need for metabolic engineering approaches for high-level Taxol production i

98 the use of biological grafts and alternative engineering approaches have made progress.

99 al bacterial delivery, from internal genetic engineering approaches to external encapsulation and mod

100 Today, the integration of CRISPR engineering approaches with hiPSC-based models permits p

101 Diverse efforts in protein engineering are beginning to produce novel kinds of symm

102 arallel, cellular reprogramming and organoid engineering are expanding the use of human neuronal mode

103 ciences, power transportation, economics and engineering are often described as multilayer networks.

104 henomena in developmental biology and tissue engineering are the result of feedbacks between gene exp

105 in vivo extracellular recording and genetic-engineering-assisted optical stimulation is a powerful t

106 ry generation problems, ranging from protein engineering attempts that leverage mutual information to

107 lution of NLRs, give an overview of previous engineering attempts, and propose how to use evolutionar

108 Engineering bacteria to clean-up oil spills is rapidly a

109 demonstrates efficient optical metamaterial engineering based on structured ensembles of atoms(4,8,9

110 ly involves many parameters, making material engineering based on trial and error highly inefficient.

111 e an arrayed CRISPR screening method, Genome engineering-based Interrogation of Enhancers (GenIE), wh

112 rogels are increasingly attractive in tissue engineering because they provide a xeno-free, biocompati

113 t there is no loss in bioturbation ecosystem engineering behaviors after the mass extinction, and sec

114 ancer, these studies are relevant for tissue engineering, biological effects of materials, tissue and

115 However, engineering biomolecular self-assembly at solid-liquid i

116 ver the past two decades has been devoted to engineering biosensors specific for ions, nucleotides, a

117 m cells (MSCs), are excellent candidates for engineering bone, but lack reproducibility due to donor

118 of anabolic bone is the primary goal of bone engineering, but achieving this is challenging.

119 es are remarkably effective tools for genome engineering, but have limited target ranges due to their

120 Defect engineering can enhance key properties of metal-organic

121 o demonstrates that efficient surface ligand engineering can exploit the unique electrochemical prope

122 Post-SELEX aptamer engineering can improve aptamer performance, but current

123 Vector engineering can increase AAV transduction efficiency (by

124 Genome stability is essential for engineering cell-based devices and reporter systems.

125 ove useful in making superhard materials and engineering ceramics.

126 ied at the single-cell level, due largely to engineering challenges related to sample stability, heat

127 oming several computational, statistical and engineering challenges.

128 ips in photonics, photochemistry, biomedical engineering, chemical engineering, and beyond.

129 ng magnetic oxides and identify paths toward engineering chiral and topological states in centrosymme

130 ll be of particular relevance to the crystal engineering community, whose goal is the design of solid

131 een given to analyzing patterns in ecosystem engineering complexity as a result of the extinction dri

132 neered cell-based therapies in which genetic engineering could enhance therapeutic efficacy and insta

133 undergraduate cohort freshly admitted to an engineering department ([Formula: see text]).

134 ditions, photoreactivity, water quality, and engineering design in the sunlight inactivation of virus

135 In engineering design, incorporating certain non-Markovian

136 ttlenecks in a broad range of scientific and engineering disciplines(1,2).

137 and open a new direction in precision defect engineering, down to a single defect, towards achieving

138 applicability of droplet sorting to protein engineering, drug discovery, and diagnostic workflows.

139 transposase proteins, and will guide protein engineering efforts to leverage this system for programm

140 presents a promising target for breeding or engineering efforts to reduce fruit transpirational wate

141 rning models to effectively direct metabolic engineering efforts.

142 bacterial organelles and will aid downstream engineering efforts.

143 technique for cellular pathway analysis and engineering, EFM application to genome-scale models rema

144 y, pharmaceuticals, food chemistry, chemical engineering, etc.

145 urface protection, materials and electrolyte engineering, etc.).

146 C)-based technology with CRISPR-based genome engineering facilitates precise isogenic comparisons of

147 on time, with the remaining time lost due to engineering faults (0.6% of the time), CO(2) supply issu

148 , and expertise from multiple biomedical and engineering fields will be needed to fully realize the p

149 tors in bacterial metabolism, their rational engineering for commercial metabolite production in phot

150 hich has the potential to revolutionise cell engineering for therapeutic applications.

151 ut also sheds light on the role of separator engineering for various electrochemical energy storage d

152 gulated through structural and compositional engineering from the macroscale down to the nanoscale, i

153 , and 2) minimize the nND immune response by engineering fusion proteins consisting of gp120 Core and

154 advances in fundamental immunology, genetic engineering, gene editing, and synthetic biology exponen

155 gnetoelectric effect in permanent magnets by engineering grain boundaries with hydrogen atoms.

156 heoretical analysis of the system, providing engineering guidelines for its design and operation.

157 The field of tissue engineering has advanced over the past decade, but the l

158 CRISPR-Cas genome engineering has revolutionized biomedical research by en

159 Breakthroughs in materials engineering have accelerated the progress of immunothera

160 th the Heidelberg HRA-Spectralis (Heidelberg Engineering, Heidelberg, Germany).

161 eric serum protein and was selected here for engineering higher-valency molecules because of its comp

162 Through the dispersion engineering, highly confined field distribution has been

163 Genome-scale engineering holds great potential to impact science, ind

164 I-C Cascade-based system for targeted genome engineering in bacteria.

165 oping, complex, and under-recognized role of engineering in medicine to address the multitude of chal

166 establish a foundation for correlated defect engineering in PBAs as a means of controlling storage ca

167 Here we report the engineering, in vitro biochemical characterization, stru

168 ing using the Spectralis HRA+OCT (Heidelberg Engineering, Inc., Heidelberg, Germany).

169 osing the correct combination of targets for engineering increased fruit yield.

170 c-field-tunable TDBG provides a new route to engineering interaction-driven quantum phases.

171 e lattice self-assemblies--shedding light on engineering intermolecular interactions for self-assembl

172 Here, we report a strategy of engineering intrafillable microstructures that can signi

173 Cardiac tissue engineering is a promising approach to treat cardiovascu

174 The microfluidics engineering is central to achieve a controlled functiona

175 ellular processes in tissue and regenerative engineering is now easily possible.

176 O(3-) (x) nanosheets via photoinduced defect engineering is proposed.

177 -H bond formation pathways through molecular engineering, is unprecedented in electrocatalysis.

178 enzymatic assays, mutant analysis, metabolic engineering, isotope labeling and metabolic profiling to

179 sted efficiently through photoinduced defect engineering; it can be anticipated that this synthesis s

180 in toughness compared with a frequently used engineering joint.

181 3D printing (3DP) has transformed engineering, manufacturing, and the use of advanced mate

182 tigue-resistant hydrogel coatings on diverse engineering materials with complex geometries.

183 We highlight biomolecular engineering methodologies to assemble, regulate, and del

184 alleviate the hurdles of conventional tissue engineering methods by precise and controlled layer-by-l

185 Engineering microrobots is increasingly receiving attent

186 is a challenge for which the field of tissue engineering might offer promising solutions.

187 nology and 3D bioprinting to urethral tissue engineering might present solutions to these issues.

188 Thus, one key challenge in engineering molecular signaling systems involves the des

189 During the last two decades, engineering motion with small-scale matter has received

190 mponents and their cellular function, and to engineering new molecular functionalities.

191 l for elucidating mechanisms of function and engineering new therapeutics and nanotechnologies.

192 Here we report that Fc engineering of anti-influenza IgG monoclonal antibodies

193 Herein, we report the expression and engineering of Azotobacter vinelandii NifEN in Escherich

194 Herein, for the first time, the engineering of C(3) N(4) layers with single-atom Cu bond

195 Genetic engineering of cis-regulatory elements in crop plants is

196 To inform the rational engineering of collagen-like peptides and proteins for f

197 er of examples in the literature of targeted engineering of conformational dynamics being successfull

198 Here we report the engineering of CRISPR Artificial Splicing Factors (CASFx

199 s the prospects of sigma factor in metabolic engineering of cyanobacteria, summarizes the challenges

200 enes in wheat to accelerate the breeding and engineering of disease-resistant varieties.

201 d makes it a powerful tool for the discovery/engineering of Fabs and IgGs.

202 ntly expands the possibilities for metabolic engineering of GalOA production and valorization of pect

203 to mammalian cells all at once or extensive engineering of gene regulatory sequences can be used to

204 ons(2-5), however, have greatly hampered the engineering of low-entropy molecular systems(6).

205 and tested their utility for precise somatic engineering of missense mutations in key cancer drivers.

206 Through in vitro engineering of MT7 finger regions that was guided by the

207 rboxysomes have inspired rational design and engineering of new nanomaterials to incorporate desired

208 thermodynamic driving motif is ideal for the engineering of non-equilibrium systems that rely on cata

209 is an effective approach for the design and engineering of novel functional peptides because hybrid

210 ties enable the rational design and holistic engineering of novel materials for more capable biocompa

211 genetic engineering of promastigotes for cytosolic accumulation

212 into an automated format for high-throughput engineering of small-molecule-binding aptamers to acquir

213 Genetic engineering of stem cells yields augmented therapeutic c

214 tably encode such programs would advance the engineering of synthetic organisms and ecosystems with r

215 Compositional engineering of the "A" site cation of the ABX(3) perovsk

216 Engineering of the essential CENTROMERIC HISTONE (CENH3)

217 nd will enable rational design and molecular engineering of the filler-matrix interfaces of electroac

218 Finally, by further sequence engineering of the set of template/blocker scaffolds and

219 e findings suggest the possibility of strain engineering of the transport properties of BAs for appli

220 to the physiological analysis and metabolic engineering of this bacterium, and provide directions fo

221 ploring MbA biosynthesis to enable metabolic engineering of this rare and valuable compound.

222 -range defect of MVA may allow more rational engineering of vaccines for efficacy, safety, and propag

223 tise but without formal training in software engineering or computer science.

224 omosomes could be fused by deliberate genome engineering or forced to fuse spontaneously by blocking

225 The approach to E2 antigen engineering outlined here provides an avenue for the dev

226 fore provides the mechanical foundations for engineering passive-flow limiters into fluidic devices.

227 By re-engineering peptidoglycan synthesis, we have constructed

228 There is considerable interest in engineering plant cell wall components, particularly lig

229 ins in SA signalling and their potential for engineering plant immunity.

230 Engineering plants to accumulate oils in vegetative tiss

231 The design principles for engineering plasticity described can be applied to numer

232 This study establishes a precise genetic engineering platform for genetic studies of hMSCs and de

233 eveloping such systems becomes a commonplace engineering practice, with accepted and trustworthy deli

234 systems not only establish a set of general engineering principles which can be used to convert natu

235 des a systematic design methodology to solve engineering problems, based on the fundamental understan

236 n ability that can be used to monitor tissue engineering processes for applications in regenerative m

237 Although a C(2) engineering program would encounter many of the same cha

238 er many of the same challenges faced by C(4) engineering programmes, the simpler leaf anatomical requ

239 n of regulatory networks as part of cellular engineering projects, whether it be to stage processes d

240 Improving soil engineering properties is an inevitable process before c

241 ductivity in TBG and open up avenues towards engineering quantum phases in moire systems.

242 Efficient precision genome engineering requires high frequency and specificity of i

243 Diseases (5T32DK07352), Natural Sciences and Engineering Research Council of Canada (PDF-532926-2019)

244 vate a campus culture of ethical science and engineering research in the very work settings where lab

245 Genome engineering revealed that two enhancers with half EREs c

246 s study opens up a new opportunity to design engineering rods or columns with superior buckling resis

247 and have implications with regard to future engineering schemes, leading to better crop yields.

248 The vibrancy of the engineering science associated with these platforms, the

249 undamentally limited and can be broadened by engineering selective optical coupling mechanisms to the

250 Engineering sequence-specific antibodies (Abs) against p

251 l coding, drug delivery, diagnostics, tissue engineering, shear-induced gelation, and functionally en

252 Furthermore, engineering similar hetero-polymer formation into angios

253 We draw on conceptions in software engineering, socio-technical systems engineering, and a

254 surface, thus can be used to create frontier engineering solutions.

255 nsights into metabolic functions, and derive engineering strategies for manipulation of metabolism.

256 Cardiac tissue engineering strategies have the potential to regenerate

257 g the current obstacles with a wide range of engineering strategies in order to improve the safety, e

258 ts, suggesting a critical reconsideration of engineering strategies to overcome the coercivity limits

259 Here, the design and engineering strategies used to develop the optimal bulk

260 ation of conventional breeding and metabolic engineering strategies, should enable a leap forward wit

261 pled mechanical work by ClpAP and provide an engineering strategy that will be useful in testing othe

262 We developed a structural engineering strategy to immobilize a molecular catalyst

263 ions to ultrasonic sensing and evaluation of engineering structures.

264 Harnessing conformational dynamics in engineering studies is a powerful paradigm with which to

265 ri-aspartate architectures, which allows for engineering such a selective multivalent metal ion bindi

266 fic hardware across many different fields of engineering, such as integrated circuits, memristors, an

267 Here, we combine protein engineering, surface plasmon resonance characterization,

268 different formalisms, that will be useful in engineering, synthetic biology, microbiology and genetic

269 Engineering T lymphocytes is an emerging approach in a v

270 The recent advance in genome engineering technologies based on CRISPR/Cas9 system is

271 Later, the spread of genetic engineering technology enabled investigators to develop

272 ltration, sensing, drug delivery, and tissue engineering that often require the fibers to be patterne

273 Engineering the assembly of nanoscale objects into compl

274 creating assembled structures from polymers, engineering the assembly of polymeric materials into fra

275 By engineering the CRISPR-AsCas12a system with key modifica

276 By engineering the number density of adsorbed nanoparticles

277 Engineering the particle size and Fe doping is critical

278 fication of development is a path forward to engineering the plants of the future, provided we know e

279 the phage DNA throughout the infection, but engineering the relocalization of EcoRI inside the compa

280 We have thus developed avenues for engineering the surface of nanoparticles for biological

281 When aiming at engineering the thiamine (vitamin B1) pathway in plants,

282 aterial synthesis is that, through substrate engineering, the orientation of graphitic planes within

283 Climate engineering-the deliberate large-scale manipulation of t

284 lgal CCMs, as well as recent advances toward engineering these components into land plants.

285 into morphogen evolution and a platform for engineering tissues.

286 erry, another Solanaceae plant, also enabled engineering to a compact stature.

287 Moreover, we use genome engineering to demonstrate that precise mutation of hth

288 o identify a missing pathway enzyme, protein engineering to enable the functional expression of an ac

289 A key aim in exploiting CRISPR-Cas is gRNA engineering to introduce additional functionalities, ran

290 Optimization and reverse-engineering to remove ER activity led to a novel compoun

291 confinement effects facilitate wave function engineering to sculpt the spatial distribution of charge

292 specificity and kinetics of Cas9 as a genome engineering tool and may inspire expanded applications t

293 rful tools for greatly expanding the protein engineering toolkit.

294 r lipid bilayers in conjunction with protein engineering, we explicate the mechanism by which the int

295 In contrast to a top-down method of tissue engineering where the differentiation of cells is guided

296 Engineering with biomolecular motors has the potential t

297 scope of possibilities for colloidal crystal engineering with DNA.

298 Here, by combining genetic engineering with quantitative super-resolution stimulate

299 tegic selection of substrate cells, and gene-engineering with synthetic co-stimulatory circuits.

300 hypothesized that ML differentiation and CAR engineering would result in complementary improvements i