ライフサイエンスコーパス: engineering of

1 oelectric textures, opening a new avenue for engineering of 2D material properties.

2 Here, we demonstrate controlled strain engineering of 2D semiconductors during synthesis by uti

3 and provide important insights into defects engineering of 2G HTS coil wires.

4 tion into the heart in animal models and the engineering of 3D heart tissues with electromechanical c

5 The genetic engineering of a biophysical CCM into land plants is bei

6 Here we describe the engineering of a catalytically active ADAR3 enzyme using

7 Engineering of a CGFS-type Grx with a CxxC/S-type loop a

8 report the discovery, characterization, and engineering of a completely cysteine-less split intein (

9 e panel of 208-HIV-1 strains, as well as the engineering of a crystal lattice to enable structure det

10 Engineering of a CxxC/S-type Grx with a CGFS-type loop s

11 proof-of-concept, we recount the successful engineering of a cysteine-less mutant of the group II ch

12 Here we report the engineering of a cytochrome P450 enzyme by directed evol

13 Here, we report the engineering of a novel class of basal oral insulin analo

14 CAR T-cell treatment involves genetic engineering of a patient's T cells by insertion of a CAR

15 Here we report the engineering of a protein scaffold for preferential bindi

16 ct product properties and may assist reverse engineering of a range of dairy products.

17 s this goal, we report the domestication and engineering of a scCO(2)-tolerant strain of Bacillus meg

18 Here, we report the engineering of a series of monomeric and dimeric designe

19 Herein, we report the design and engineering of a system to remotely monitor and control

20 Tissue engineering of a transplantable liver could provide an a

21 ategies are expected to be applicable to the engineering of a wide range of light-activated phosphata

22 Further study and engineering of AAA+ translocases like Hsp104 and PAN wil

23 They might also be of relevance for rational engineering of Abs for optimizing their pharmacokinetic

24 es such chromophores are rare, and molecular engineering of absorbers having such properties has prov

25 The engineering of active warfare between microbial species

26 eds light on further surface and interfacial engineering of advanced hybrid materials.

27 presence of H(2) S constrains the design and engineering of advanced membranes for such challenging a

28 acilitate genomic identification of PALs and engineering of AEPs into PALs.

29 e the intriguing possibility of the rational engineering of allosterically modulated DNA origami.

30 We investigated strain engineering of alpha-formamidinium lead iodide (alpha-FA

31 a computational method (FRESCO) to guide the engineering of an alcohol dehydrogenase.

32 Here we describe the engineering of an antibody fusion protein, termed F8-4-1

33 Here we report that Fc engineering of anti-influenza IgG monoclonal antibodies

34 The present work describes the engineering of anti-PSMA peptide-decorated exosome mimet

35 endogenous and exogenous vaccination, to the engineering of antigen-presenting cells and T cells, and

36 ffinity to EGFR was finely tuned by rational engineering of aptamer sequences to define receptor moti

37 These limitations have prevented the engineering of ATs with low native promiscuity and the s

38 Herein, we report the expression and engineering of Azotobacter vinelandii NifEN in Escherich

39 One particular area of focus has been the engineering of bacteria as therapeutic delivery systems

40 ecombinant Ab Pair, or pY-TRAP, for in vitro engineering of binders for native pY proteins.

41 re conditions, such as oxygen supply, in the engineering of bioartificial pancreatic islets to ensure

42 The engineering of biological molecules is a key concept in

43 Reverse engineering of biological networks from high-throughput

44 laser excitation, thus paving the way to the engineering of biologically inspired hybrid NIR nonlinea

45 The colorimetric assay can propel the engineering of biosynthetic routes to novel chemical div

46 This process enables engineering of bone models replicating the key hallmarks

47 Herein, for the first time, the engineering of C(3) N(4) layers with single-atom Cu bond

48 analysis and contextualize them towards the engineering of candidate antibody therapeutics.

49 t only presents deep insights for the defect engineering of carbon-based materials but also improves

50 ual biosynthetic transformations, and to the engineering of catalysts for generating new products.

51 Our results demonstrate that facet engineering of cathode catalysts could be a new way to t

52 Here, we propose that facet engineering of cathode catalysts could be another direct

53 Our results demonstrate that protein engineering of CCDs significantly increases the yield of

54 is holistic synthetic biology concept to the engineering of cell-free systems by exploiting the cross

55 protein function have enabled modulation and engineering of cellular functions.

56 tem's critical objectives is also needed for engineering of cellular metabolism, where there is inter

57 platform will enable tunable and reversible engineering of cellular RNAs for diverse applications.

58 nabinoid inheritance to facilitate metabolic engineering of chemically elite germplasm.

59 Here we describe the engineering of chemically optimized antisense oligonucle

60 se limitations, the present work reports the engineering of circular bivalent aptamer-drug conjugates

61 Genetic engineering of cis-regulatory elements in crop plants is

62 To inform the rational engineering of collagen-like peptides and proteins for f

63 Hereby, we lay the ground work for the engineering of colloidal supraparticle-based synthetic p

64 ation cycle, this enables successful forward engineering of complex aromatic amino acid metabolism in

65 and the velocity of the liquid jet, enabling engineering of complex micromaterials in jetting regimes

66 er of examples in the literature of targeted engineering of conformational dynamics being successfull

67 With recent advances in the engineering of connective tissues, including arteries, w

68 Here we report the engineering of CRISPR Artificial Splicing Factors (CASFx

69 d we provide candidate genes for breeding or engineering of crops for biofuels or the production of i

70 CsPbI(3) :Br:InI(3) , is prepared by defect engineering of CsPbI(3) .

71 s the prospects of sigma factor in metabolic engineering of cyanobacteria, summarizes the challenges

72 to spectroscopy, kinetics, and modeling, the engineering of defective nodes via controlled thermal ap

73 Structure-based enzyme engineering of DHPAAS results in bifunctional switching

74 erstanding of the mechanism enables informed engineering of different levels of smectic order in vapo

75 Ge-oxide interface is demonstrated, which is engineering of diffusion species in the ALD process due

76 enes in wheat to accelerate the breeding and engineering of disease-resistant varieties.

77 d in Gc crystals at neutral pH, allowing the engineering of disulfide bonds to cross-link spikes.

78 therapeutic potential, chemical and genetic engineering of Dps will offer a nanoplatform to advance

79 We use genome engineering of Drosophila to investigate constraints on

80 Molecular engineering of efficient HER catalysts is an attractive

81 ith a controlled twist angle(1-3)-enable the engineering of electron band structure.

82 e pathway for Fermi surface topology and VHS engineering of electronic phases.

83 y catalysts with the strategy of topological engineering of excellent transitional catalytic material

84 for many-body physics with neutral atoms and engineering of exotic quantum matter.

85 d makes it a powerful tool for the discovery/engineering of Fabs and IgGs.

86 We discovered that genetic engineering of Fas variants impaired in the ability to b

87 ystems can offer an extensive ground for the engineering of functional materials with advanced optoel

88 The present demonstration of surface engineering of functional redox-active organometallic mo

89 Engineering of functionalized RNA-binding proteins (RBPs

90 ing site within vancomycin, and could direct engineering of future therapeutics.

91 ntly expands the possibilities for metabolic engineering of GalOA production and valorization of pect

92 Reverse engineering of gene regulatory networks from time series

93 to mammalian cells all at once or extensive engineering of gene regulatory sequences can be used to

94 recombineering have enabled high-throughput engineering of genetic circuits and biosynthetic pathway

95 lasses of RNA devices, thereby advancing the engineering of genetic devices for mammalian systems.

96 useful tool for studies of filovirus entry, engineering of GP variants with enhanced stability for u

97 In this study, we combine protein engineering of GPCR-G protein interactions with affinity

98 e therapy trials have shown that the genetic engineering of haematopoietic stem and progenitor cells

99 he controllable and device-compatible strain engineering of halide perovskites by chemical epitaxy re

100 represents a proof of concept that rational engineering of HCV envelope glycoproteins can be used to

101 resent a transformational approach to genome engineering of herpes simplex virus type 1 (HSV-1), whic

102 We report, for the first time, engineering of heteropolar cardiac tissues containing di

103 n provides a chirality-based methodology for engineering of hierarchically organized ceramic material

104 n completely sequenced, leading to metabolic engineering of high eicosapentaenoic acid producing stra

105 Ultimately, Fc engineering of human glycan-targeting IgG1 mAb confers p

106 The engineering of immunoglobulin-G molecules (IgGs) is of w

107 ing of the dynamics of RNA aptamers will aid engineering of improved fluorogenic modules for cellular

108 research over the last decade has led to the engineering of in vitro models of the liver to aid in dr

109 fic biomarkers present opportunities for the engineering of in vitro pathology-sensitive biosensors.

110 ts in neurodegenerative disease research and engineering of in-vitro multi-cellular living systems.

111 chemistry, thereby permitting the bottom-up engineering of increasingly complex reaction networks fr

112 CaSSA allows engineering of independent genetic switches, each respon

113 ise a solid-state platform for quantum-state engineering of isolated many-body systems.

114 an experimental system that combines genetic engineering of kinase activity and quantitative proteomi

115 n by a discrete nucleation domain may enable engineering of kinetically controllable self-assembling

116 s Safe and often employed as probiotics, the engineering of Lactobacillus membrane vesicles presents

117 reate therapeutic bispecific antibodies, the engineering of light-inducible proteins that can be used

118 Genetic engineering of lignocellulosic biomass has previously fo

119 ly been investigated and shows that chemical engineering of lipid siRNAs is essential to advance the

120 ons(2-5), however, have greatly hampered the engineering of low-entropy molecular systems(6).

121 re morphology is a prerequisite for rational engineering of magnetic ground states.

122 Thus, omics-guided engineering of mammalian cell culture can be deployed to

123 The engineering of materials with controlled magnetic proper

124 sotropy in self-assembled structures enables engineering of materials with highly directional respons

125 IgG transplacental transport, suggesting Fc engineering of maternally administered antibody to enhan

126 cial regions, BMSCs appear more suitable for engineering of mature vascularized networks than DPSCs o

127 Here we show how the precise engineering of metal-organic frameworks (MOFs) holds pro

128 Defect engineering of metal-organic frameworks (MOFs) offers pr

129 tivity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 c

130 Engineering of microbial communities in open environment

131 ian transitions, symbioses, and for top-down engineering of microbial communities.

132 ing of natural microbial communities and the engineering of microbial consortia.

133 ios across scales and environments: from the engineering of millimeter-long bio-hybrid robots to the

134 Main challenges in the engineering of miRNA-loaded nanoparticles are discussed,

135 and tested their utility for precise somatic engineering of missense mutations in key cancer drivers.

136 Thus, CAR engineering of ML NK cells enhanced responses against re

137 port a generalizable methodology that allows engineering of modified lipid nanoparticles to efficient

138 adsorption study sheds light on the rational engineering of molecular interaction(s) with achiral mic

139 benzene as a versatile aromatic scaffold for engineering of molecular materials with tailored and exp

140 n, allowing for high-throughput modeling and engineering of molecular mechanisms.

141 an oxygen-rich atmosphere and may guide the engineering of more efficient RuBisCOs.

142 munocompetent HNSCC mouse models, as well as engineering of more robust immune adjuvant delivery syst

143 ing its activity in response to stresses for engineering of more sustainable crops for food and biofu

144 r coexistence is a promising route in defect engineering of MoS2 to fabricate suitable devices for el

145 Combining genetic engineering of MPK4 activity and quantitative proteomics

146 Through in vitro engineering of MT7 finger regions that was guided by the

147 This work represents a foundation for the engineering of multicompartment-spanning designer pathwa

148 These results may guide the rational engineering of multilayer and core-shell oxide nanomater

149 Sequential engineering of multiple catalytic sites in MOFs thus pre

150 ally "noisy" bioenvironments require careful engineering of nanoscale components that are highly sens

151 The engineering of nanoscale features enables the properties

152 theoretically and experimentally the quantum engineering of nanoscale Kondo lattices - Kondo droplets

153 ovides insights on the design, and potential engineering, of nanoscale electrical contacts with contr

154 ignificant efforts have been directed toward engineering of nanosurfaces with low complement activati

155 tock of the advances made in the science and engineering of NC systems, challenges and opportunities

156 etic doping of atomically-thin materials and engineering of near-surface states of semiconductor devi

157 eous solution, as well as guidelines for the engineering of new applications in water.

158 proach in the discovery of novel enzymes and engineering of new catalytic activity into existing ones

159 rboxysomes have inspired rational design and engineering of new nanomaterials to incorporate desired

160 tissue, CT; glycocalyx) of donor organs, and engineering of new organs are under investigation.

161 ded here form a sound basis for the rational engineering of NMT enzymes for chemoenzymatic synthesis

162 , or other cells derived from endoderm); the engineering of non-beta-cells that are capable of modula

163 thermodynamic driving motif is ideal for the engineering of non-equilibrium systems that rely on cata

164 he genetic determinants of phenotype and the engineering of novel behaviors in organisms.

165 is an effective approach for the design and engineering of novel functional peptides because hybrid

166 ial applications of these approaches for the engineering of novel functionalities in plants, includin

167 ties enable the rational design and holistic engineering of novel materials for more capable biocompa

168 ll spur the critical thinking for design and engineering of novel MNPs for MRI applications across a

169 a with correlated disorder and stimulate the engineering of novel non-resonant random lasers with sig

170 this study will facilitate rational genetic engineering of NRPS to generate unnaturally methylated N

171 utlook are provided for guiding the rational engineering of OER electrocatalysts for applications in

172 Here, we report the engineering of one of the most stable MOFs, Zr-UiO-66, w

173 in disadvantage is the lack of deterministic engineering of one or more of the many random photonic m

174 th important implications for the design and engineering of optimised Ad-based therapeutics.

175 c skyrmion systems, which allows for precise engineering of optimized skyrmion heterostructures.

176 BphP-PCM represents a versatile scaffold for engineering of opto-RTKs that are reversibly regulated w

177 nce indicates eIF4E may be a soft target for engineering of-or breeding for-resistance to MCMV.

178 y, CRISPR-based gene modification allows the engineering of organoid models of cancer through the int

179 Herein we report multistep sequential engineering of orthogonal Lewis acid and palladium nanop

180 Facet engineering of oxide nanocrystals represents a powerful

181 udies of Hedgehog pathway activation and the engineering of pathway activating agents for therapeutic

182 is an invaluable host for the discovery and engineering of pathways important for bioremediation of

183 As a prototypical demonstration of band engineering of PbI(2) -based interfacial semiconductors,

184 Tissue engineering of penile tissue should focus on two main st

185 chnological impact is expected in the tissue engineering of periosteum for treating bone defects.

186 findings open up opportunities for rational engineering of pharmacologically enhanced sKlotho therap

187 Anion engineering of phenethylammonium-based two-dimensional (

188 The extensive genome engineering of pigs for greater compatibility with the h

189 nal design to be successfully applied to the engineering of plant gene regulation and metabolism.

190 Genetic engineering of plants is at the core of sustainability e

191 ect extraction, recent progress in metabolic engineering of plants offers an alternative supply optio

192 synthetic biology that involve the multistep engineering of plastid genomes.

193 cal semiconductor microstructures facilitate engineering of polariton based electronic states and sen

194 Intriguingly, prudent engineering of polarized excited states can steer a "U-t

195 rganisms, and our findings could lead to the engineering of precise synthetic clocks in embryos and o

196 l and conceptual advances in genetic/genomic engineering of prokaryotes that have enabled upgrading o

197 genetic engineering of promastigotes for cytosolic accumulation

198 In the context of molecular engineering of push-pull dipolar dyes, we introduce a st

199 d control is foundational to the science and engineering of quantum systems(1,2).

200 ht and matter are strongly coupled, allowing engineering of rapid changes in the force landscape, sto

201 ) of the WLEDs clearly demonstrate that site engineering of rare-earth phosphors is an effective stra

202 therefore serve to guide any future rational engineering of replicative DNA polymerases.

203 ional dynamics, open up perspectives for the engineering of RNA-protein interfaces.

204 Thus, engineering of rSHM remains critical to enhance the stab

205 es a versatile genetic resource for rational engineering of secondary metabolite BGCs in Streptomyces

206 Here we describe structure-guided engineering of SECURE-ABE variants with reduced off-targ

207 y of the binding motif opens avenues for the engineering of semisynthetic hybrid RiPP products.

208 of in vitro applications as well as for the engineering of semisynthetic organisms (SSOs) that store

209 tates new opportunities ranging from surface engineering of SERS material tags to SERS imaging-guided

210 er, current delivery methods for the genetic engineering of single cells, including viral transductio

211 ibody-binding patterns and introduce genetic engineering of SLA epitopes.

212 into an automated format for high-throughput engineering of small-molecule-binding aptamers to acquir

213 We suggest that the engineering of specific antigenic sites can improve the

214 in RBP design remains attractive even though engineering of specificity changes is challenging.

215 5/6 Agonists, called FLAgs, enables tailored engineering of specificity for one, two or multiple memb

216 Engineering of spin-orbit synthetic Hamiltonians in opti

217 This concept of bending strain engineering of spins via topological nanomechanical arch

218 Future engineering of split markers may allow selection of a hi

219 aling will allow improved strategies for the engineering of staple crops to accumulate additional bio

220 rther understanding of stem cell biology and engineering of stem cells for therapeutic applications.

221 Genetic engineering of stem cells yields augmented therapeutic c

222 from monk fruit, and a possible template for engineering of steviol biosynthesis.

223 volution offer innumerable tools to expedite engineering of strains for optimising biosynthetic pathw

224 Our results pave the way for proximity engineering of strong topological insulators as well as

225 These results will guide future engineering of STRs and related enzymes for biocatalytic

226 which will be fundamental for the successful engineering of such hybrid systems.

227 es a framework for model-guided analysis and engineering of such interactions.

228 ting transition are important for design and engineering of superhydrophobic surfaces.

229 ession of thermal contact resistance and the engineering of surface morphology and optical property.

230 w theoretical-experimental approaches to the engineering of synthetic chemical- and light-regulated (

231 The engineering of synthetic circuitry in bacterial, yeast,

232 quitous in nature and critical for bottom-up engineering of synthetic networks.

233 opology-preserving mutations, and the robust engineering of synthetic networks.

234 lex biological interfaces as well as for the engineering of synthetic ones.

235 tably encode such programs would advance the engineering of synthetic organisms and ecosystems with r

236 gene-editing technologies, have enabled the engineering of T cells to have sophisticated sensing cir

237 l growth is essential for reconstruction and engineering of teeth.

238 Rational engineering of terpene synthases is challenging due to a

239 Compositional engineering of the "A" site cation of the ABX(3) perovsk

240 Engineering of the activatable PTPs (actPTPs) is achieve

241 s harbinger a new age of deep elastic strain engineering of the band structure and device performance

242 In particular, the deliberate engineering of the band structure in photonic materials

243 ted here can be generally applied to advance engineering of the broadening class of polymer materials

244 y laying the groundwork for deeper study and engineering of the cell biology supporting CO(2) assimil

245 thologs, and provide a basis for the further engineering of the CRISPR-Cas9 genome-editor nucleases.

246 re emerging as an effective tool for in situ engineering of the cutaneous microenvironment to enable

247 Herein, we describe the engineering of the dominant-negative MYC peptide (OmoMYC

248 Two main strategies, engineering of the electronic (d-band) structure (includ

249 Engineering of the essential CENTROMERIC HISTONE (CENH3)

250 g vdW heterostructures through the interface engineering of the exfoliation substrate using a sub-5 n

251 nd will enable rational design and molecular engineering of the filler-matrix interfaces of electroac

252 Further genetic engineering of the GAd capsid holds the promise of in vi

253 atomic-layer deposition enables atomic scale engineering of the gain layer properties and straightfor

254 ty graphene films, and the finding about the engineering of the gas-phase reaction, which is usually

255 egies and challenges regarding compositional engineering of the hybrid perovskite structure are discu

256 parameters of aldol addition and demonstrate engineering of the hydroxyl group stereoselectivity.

257 The second involves science and engineering of the largest dynamic, rotating machines in

258 pivotal concept that allows controlling and engineering of the macroscopic electronic and optical pr

259 This led to engineering of the methylmalonyl-CoA specificity of both

260 Genetic engineering of the mouse genome identified many genes th

261 for the extraction of knowledge and reverse-engineering of the much sought-after mechanistic models

262 Through the careful design and engineering of the nanoparticle formulation, it is possi

263 factors, and cis-signatures allowing reverse engineering of the NC-GRN at unprecedented resolution.

264 e been utilized extensively in the study and engineering of the organisms they describe.

265 assist in further manipulation and metabolic engineering of the parent F. solani strain towards the e

266 Engineering of the pathways providing the universal C5-b

267 transformation efficiency, will advance the engineering of the plastid genome in Arabidopsis.

268 aqueous conditions with no required genetic engineering of the proteins.

269 new technique that does not require specific engineering of the resonator dispersion to generate freq

270 mary tissue and does not require any genetic engineering of the respective sample sources.

271 Finally, by further sequence engineering of the set of template/blocker scaffolds and

272 Here we show that judicious engineering of the single-emitters that comprise the met

273 Controlled engineering of the SOPs may pave the way toward practica

274 retchability, a characteristic that requires engineering of the structure at the molecular- or nanosc

275 e findings suggest the possibility of strain engineering of the transport properties of BAs for appli

276 uity, thereby opening doors for the targeted engineering of these enzymes as useful biocatalysts.

277 at will inform the rational manipulation and engineering of these impressive multifunctional catalyst

278 Reverse engineering of these mutations revealed a conserved mech

279 ays, and also examine sample problems in the engineering of these pathways.

280 property, paving the way for reverse crystal engineering of these species.

281 ty has important implications for the future engineering of this and related species.

282 to the physiological analysis and metabolic engineering of this bacterium, and provide directions fo

283 ent analysis further facilitate the rational engineering of this enzyme to become a specific 4-argini

284 activity, and therefore the biosynthesis and engineering of this large class of molecules is therapeu

285 ploring MbA biosynthesis to enable metabolic engineering of this rare and valuable compound.

286 n important step toward the future study and engineering of this synthetic genetic polymer.

287 ing and for more rapid and assured metabolic engineering of this versatile chassis organism.

288 Similar disulfide engineering of tissue factor pathway inhibitor-1 Kunitz

289 re experimental work, including the targeted engineering of tissues and organs.

290 Reverse engineering of transcriptional regulatory networks (TRN)

291 s for a substantial degree of freedom in the engineering of transgenes capable of simultaneously expr

292 A methodology is reported for the engineering of tunable resonant photonic media with thic

293 Here we describe the engineering of two base editor architectures that can ef

294 We describe the engineering of two RAS degraders based on protein macrom

295 enomics to accelerate biological studies and engineering of V. natriegens.

296 -range defect of MVA may allow more rational engineering of vaccines for efficacy, safety, and propag

297 used as a prognostic platform for metabolic engineering of valuable natural products.

298 expand the available toolbox for the genetic engineering of vector control technologies.

299 lications presented, a vision for the future engineering of wood-based materials to promote continuou

300 Finally, we describe the engineering of XNA RTs with active exonucleolytic proofr