ライフサイエンスコーパス: enhancer activity

1 and some have been shown to be required for enhancer activity.

2 ikely to generally play a functional role in enhancer activity.

3 ARR-seq) to reliably obtain an assessment of enhancer activity.

4 atin is not sufficient for, nor specific to, enhancer activity.

5 igenetic markers of active transcription and enhancer activity.

6 SNPs within three COMs significantly altered enhancer activity.

7 f these activator sites were lost, weakening enhancer activity.

8 y establishing and simultaneously repressing enhancer activity.

9 ich only one specific group possesses active enhancer activity.

10 Lhx3 or Onecut1 binding sites into transient enhancer activity.

11 the most distal site displayed the greatest enhancer activity.

12 distal enhancers, despite generating similar enhancer activity.

13 senting an additional layer of regulation of enhancer activity.

14 ested conserved elements for transcriptional enhancer activity.

15 ring transcriptional mechanisms that control enhancer activity.

16 general association with cell-type-specific enhancer activity.

17 s, and subtle changes in their spacing alter enhancer activity.

18 hancer orthologues show fetal-brain-specific enhancer activity.

19 c location of a full ERE strongly influences enhancer activity.

20 and redistributes to open regions devoid of enhancer activity.

21 rring with RNAP2 were more likely to exhibit enhancer activity.

22 -seq demonstrates accurate quantification of enhancer activity.

23 riants for allelic differences in regulatory enhancer activity.

24 assify Drosophila cell-type-specific cardiac enhancer activity.

25 eletion from intron 1 abolishes hyperosmotic enhancer activity.

26 r NOG, we found that one, rs227727, disrupts enhancer activity.

27 how tightly coupled eRNA production is with enhancer activity.

28 variants that disrupt DNA binding and islet enhancer activity.

29 e generation of which is strongly related to enhancer activity.

30 Zld binding sites and the spatial domain of enhancer activity.

31 allelic differences in FOXA2-DNA binding and enhancer activity.

32 er functions for this motif in BMP-dependent enhancer activity.

33 ncer of PTF1A and that the mutations abolish enhancer activity.

34 ch TRFs target DNA regions with demonstrated enhancer activity.

35 differentiation and coupled with changes in enhancer activity.

36 to be upregulated by the NF-kappaB-mediated enhancer activity.

37 that denote open chromatin status and confer enhancer activity.

38 hat causes an approximately 80% reduction in enhancer activity.

39 mouse non-coding genomic DNA fragments with enhancer activity.

40 enome-wide binding profiles is predictive of enhancer activity.

41 re thereby both necessary and sufficient for enhancer activity.

42 ingless signal and apterous), and has nubbin enhancer activity.

43 site motifs accurately predicted mesodermal enhancer activity.

44 ability of eRNAs and H3K27ac to discriminate enhancer activity.

45 t Tf1 increased gene expression by inserting enhancer activity.

46 chromatin modifications, eRNA production and enhancer activity.

47 results in loss or reduction of neural crest enhancer activity.

48 ts-1, TFAP2A and FoxD3, all are required for enhancer activity.

49 ated the mechanisms that regulate hsERVPRODH enhancer activity.

50 demonstrate that eRNA is more indicative of enhancer activity.

51 alternative approach to directly predicting enhancer activity.

52 ay, along with new candidates for ubiquitous enhancer activity.

53 ': dual-action CRMs with promoter and distal enhancer activity.

54 nces, whose expression levels correlate with enhancer activity.

55 ve been proposed to both guide and constrain enhancer activity.

56 nPE2 are essential for their transcriptional enhancer activity.

57 ivity and increases basal and DMRT2-mediated enhancer activity.

58 terns that are dependent on CTCF anchors and enhancer activity.

59 ions lacking H3K27ac retain conservation and enhancer activity.

60 and its expression is associated with ARID5B enhancer activity.

61 ly mutated in prostate cancer and can impact enhancer activity.

62 enomic region surrounding the Eya1 locus for enhancer activity.

63 nied by massive and recurrent alterations in enhancer activity.

64 down reduces ARID5B expression and rs7090445 enhancer activity.

65 e effects, thereby buffering their impact on enhancer activity.

66 of these features functionally contribute to enhancer activity.

67 ssibility of an upstream genomic region with enhancer activity.

68 ets of features govern PPARgamma binding vs. enhancer activity.

69 tionally measure the effect of divergence on enhancer activity.

70 binding and that demonstrated Tbx5-dependent enhancer activity.

71 es, thereby controlling spatial and temporal enhancer activities.

72 hroughput technique to functionally quantify enhancer activities.

73 tium, and functional assays for differential enhancer activities.

74 selected candidate dsDMRs exhibit functional enhancer activities.

75 of transcription factor binding dynamics and enhancer activities.

76 of Hairless [Su(H)] discriminates PC from CC enhancer activities.

77 ween insulators, transcriptional states, and enhancer activities.

78 e silent or motif-improving changes maintain enhancer activity; (2) evolutionary conservation, nucleo

79 trength of the motif match are predictive of enhancer activity; (3) scrambling repressor motifs leads

80 sed on maintenance of endogenous OCT4 distal enhancer activity, a molecular signature of ground state

81 ted genome editing to demonstrate endogenous enhancer activity across 3 MFVs that predominantly affec

82 and in the antisense orientation to measure enhancer activities alone.

83 ers, most gained CTCF binding events exhibit enhancer activities and are induced by oncogenic transcr

84 rs of active differentiation loci as well as enhancer activities and selective gene expression.

85 t genotypes are associated with differential enhancer activities and/or transcription factor binding

86 hancer RNAs (eRNAs) and were shown to impair enhancer activity and ACTRT1 expression.

87 350-bp region within DHS-35kb which has full enhancer activity and binds interferon regulatory factor

88 To determine the relationship between enhancer activity and biological outcomes in breast canc

89 The resulting data strongly confirm the enhancer activity and cell-type specificity of enhancer

90 antagonizing Polycomb silencing, stimulating enhancer activity and cellular memory.

91 ins a common base-pair change that decreases enhancer activity and colocalizes with peaks of positive

92 nstrated strong allele-specific promoter and enhancer activity and differential binding of HNF4alpha,

93 , and risk allele association with decreased enhancer activity and differential protein binding.

94 g this motif to high affinity caused ectopic enhancer activity and eliminated Tv4-neuron expression.

95 Moreover, BRD4 occupancy correlates with enhancer activity and enhancer RNA (eRNA) transcription.

96 ith T1D-associated GWAS lead SNPs that alter enhancer activity and expression of immune genes.

97 n enhancers and ETO2 loss leads to increased enhancer activity and expression of target genes.

98 factors are necessary for NOTCH1 and notch1b enhancer activity and for correct endogenous transcripti

99 regions where apes and macaque show diverged enhancer activity and gene expression.

100 systems display more robust perturbations of enhancer activity and gene transcription with minimal of

101 g facial structures through context-specific enhancer activity and heightened sensitivity of the lowe

102 BP2, a fine-mapped T2D variant reduces islet enhancer activity and IGF2BP2 expression, and conditiona

103 that alleles of rs7090445 have differential enhancer activity and influence RUNX3 binding.

104 (Trr) branch of the COMPASS family regulates enhancer activity and is responsible for the implementat

105 found that Sox9-Brn2 and Isl1-Lhx3 regulate enhancer activity and NFIA expression in glial and neuro

106 Three regions exhibited enhancer activity and only rs1635852 displayed allelic d

107 reased IL-6 that amplified JUN-mediated CD47 enhancer activity and protein expression.

108 tory elements, mapping of disease-associated enhancer activity and reconstruction of trajectories of

109 factors bound to rs3780181 alleles decreases enhancer activity and reduces at least VLDLR expression,

110 ain development requires an understanding of enhancer activity and regulation.

111 scription factors that are essential for zli enhancer activity and Shh expression in the mouse embryo

112 The dynamic binding influences enhancer activity and shows enrichment for regulators li

113 d rs13294895 have allele-specific effects on enhancer activity and suggest chromatin interactions wit

114 MLL3 and MLL4 function in the regulation of enhancer activity and that mutations of MLL3 and MLL4 th

115 features found to drive condensation promote enhancer activity and transcription in cells.

116 re highly conserved and enriched in marks of enhancer activity and transcription.

117 d transcripts does not influence measures of enhancer activity and we cannot detect evidence of purif

118 hancers, suggesting that these SNPs modulate enhancer activity and, consequently, gene expression.

119 is of selected co-occupied elements verified enhancer activity, and also showed that the occurrence o

120 tly correlates with increased accessibility, enhancer activity, and cohesin occupancy at these sites.

121 risk variants determined haplotype-specific enhancer activity, and CRISPR-mediated inhibition of the

122 d by enhancer hypermethylation, reduction of enhancer activity, and delayed gene induction in the ear

123 thm determined that chromatin accessibility, enhancer activity, and distance to the transcription sta

124 ults reveal that DNA demethylation modulates enhancer activity, and its disruption influences the tim

125 Whether promoter and enhancer activities are encoded distinctly in DNA sequen

126 We found that enhancer activities are retained inside a genomic region

127 l to T2D risk, but the gene targets of islet enhancer activity are largely unknown.

128 tinct underlying DNA sequences and divergent enhancer activity as marked by histone 3 containing the

129 represent the absolute expression limits of enhancer activity, as expression activity is lost stepwi

130 motifs that are predictive and required for enhancer activity, as we validate experimentally.

131 Further analysis revealed an enhancer activity at genomic region surrounding rs463183

132 null mice, hepatocyte Bcl6 ablation restores enhancer activity at PPARalpha-dependent genes and overc

133 d uncover widespread coordination of dynamic enhancer activity at preformed and acquired DNA loops.

134 revealed that RA-RARalpha directly regulated enhancer activity at Th1 lineage defining genes while re

135 Architectural stripes appear to be driven by enhancer activity, because they do not form in mouse emb

136 described FOX:ETS-dependent enhancers, ECE1 enhancer activity becomes restricted to arterial endothe

137 egulates not only temporal changes in target enhancer activity but also spatial patterns.

138 nf32 gene lying within the Shh domain evades enhancer activities by a process that may be common amon

139 17226398, rs56038622, and rs2271338, reduced enhancer activity by 40% in neuroblastoma and astrocytom

140 We have demonstrated its virus-inducible enhancer activity by analyzing epigenomic profiles, tran

141 reporter constructs, which were analysed for enhancer activity by injection into Xenopus laevis embry

142 Enhancer activities can be inferred from enhancer RNA (e

143 olution map of eRNA loci through which super-enhancer activities can be quantified by RNA-seq and a u

144 defects in SWI/SNF targeting and control of enhancer activity cause extensive dysregulation of gene

145 Insufficiency of enhancer activity causes variegated Cd8 expression in CD

146 Loss of UTX leads to attenuated enhancer activity, characterized by reduced levels of H3

147 ion factor expression and function, promoter/enhancer activities, chromatin regulators, and three-dim

148 FoxA proteins to be required for maintaining enhancer activity, chromatin accessibility, nucleosome p

149 0181-A risk allele showed significantly less enhancer activity compared with the G allele, consistent

150 hromatin environment, including differential enhancer activities, contributes to various p53-dependen

151 ided a quantitative metric of Tbx5-dependent enhancer activity, correlating with target gene expressi

152 Enhancer activity could not be recovered by T-cell activ

153 We leverage gains in tumor-specific enhancer activity, coupled with allele-biased mutation d

154 , we show that KLK3e processes RNA-dependent enhancer activity depending on the integrity of core enh

155 ions of chromatin modification in regulating enhancer activity during development.

156 Here, we evaluated regulation of enhancer activity during differentiation of embryonic st

157 ers, we find that DNA methylation status and enhancer activity during early zebrafish development dis

158 of sequences examined display p53-dependent enhancer activity during the DNA damage response.

159 vides a quantitative readout of promoter and enhancer activity, during human, rhesus, and mouse limb

160 ulatory element 12 kb upstream of HLA-G with enhancer activity, Enhancer L Strikingly, clustered regu

161 nine autoimmune diseases and Brain-specific enhancer activities exclusively in Schizophrenia.

162 nsgenic reporter assays in zebrafish confirm enhancer activities for many HOXA1-bound regions and the

163 able to learn reliable statistical models of enhancer activity for over 70 expression domains and app

164 ally, mouse transgenic experiments validated enhancer activity for pREs proximal to FEZF2 and BCL11A.

165 Here we examine the underlying basis of enhancer activity for the Ciona intestinalis betagamma-c

166 Two elements showed strong enhancer activity for the promoters of EHF and the 5' ad

167 r absence of tamoxifen, indicating divergent enhancer activity for tumors that develop in different e

168 Here, we perform a genome-scale analysis of enhancer activity from p53-bound sequences using a serie

169 ndividual enhancers to top-down profiling of enhancer activities genome-wide, it has become increasin

170 factors, i.e. the regulatory grammar, drives enhancer activity have been proposed, ranging from the f

171 of LDTF binding, chromatin accessibility and enhancer activity have not yet been systematically evalu

172 reened 15 conserved non-coding sequences for enhancer activity, identifying three that regulate expre

173 s, characterisation of their spatio-temporal enhancer activities in a mammalian model system remains

174 s play critical roles in cancer, quantifying enhancer activities in clinical samples remains challeng

175 nding and sequence features that distinguish enhancer activities in distinct subsets of heart cells.

176 demonstrate that this region shows specific enhancer activities in iridophores, a type of pigment ce

177 We then use it to profile promoter and enhancer activities in the cellular response to TGF-beta

178 The DHS-35kb contains an element with enhancer activity in 16HBE14o- airway epithelial cells a

179 diabetes-associated variants were tested for enhancer activity in 832/13 and MIN6 insulinoma cells.

180 f multiple weak constituents can alter super-enhancer activity in a manner greatly exceeding repressi

181 leotide polymorphism, rs577676, which alters enhancer activity in a mouse atrial cell line and in emb

182 P3) contains a TATA-box and displays in vivo enhancer activity in a pattern that overlaps with the ze

183 hese, only rs5758550 demonstrated regulating enhancer activity in a reporter gene assay.

184 environmental stresses and disease, testing enhancer activity in animals remains tedious, with a min

185 d to functional assays, and all four exhibit enhancer activity in B but not in T lineage cells.

186 s surrounding these signals are enriched for enhancer activity in cranial neural crest cells and cran

187 ion factor, reducing LEF1 responsiveness and enhancer activity in cultured human keratinocytes.

188 aberrant DNA methylation and cause perturbed enhancer activity in cytogenetically normal AML that con

189 bless snakes to reveal widespread sharing of enhancer activity in developing limbs and genitalia.

190 tterning and differentiation and analysis of enhancer activity in Dlx1/2 and Lhx6 mutants, we elucida

191 and Anolis lizards reveals that patterns of enhancer activity in embryonic limbs and genitalia overl

192 ject, as well as through in vivo analysis of enhancer activity in embryonic zebrafish.

193 Marco, a gene recently demonstrated to have enhancer activity in embryonic-derived but not postnatal

194 ated variants disrupting cytokine-responsive enhancer activity in human beta cells.

195 on spanning rs3780181 exhibited 1.6-7.6-fold enhancer activity in human HepG2 hepatocyte, THP-1 monoc

196 We show that one of these elements has enhancer activity in human keratinocytes and zebrafish p

197 sk allele for this SNP increases FOXA2-bound enhancer activity in islet- and liver-derived cells.

198 Rs17134155 showed significant enhancer activity in luciferase assays, and haplotypes c

199 throughput strategy to quantitatively assess enhancer activity in mammals.

200 (77%) of the individual TEs tested exhibited enhancer activity in mouse ESCs.

201 g (CoupTFI, Pax6, and Pbx1), and analysis of enhancer activity in Pax6 mutants.

202 occupancy by p300, and a majority exhibited enhancer activity in reporter gene assays.

203 ents increased H3.3 enrichment and displayed enhancer activity in settings of injury- and/or Neuregul

204 We determine two key parameters of enhancer activity in single cells: their penetrance in a

205 adjacent SNPs had the function of regulating enhancer activity in skeletal muscle myoblasts cells, fu

206 d that Lmx1a-binding sites were required for enhancer activity in the cortical hem in vivo Mis-expres

207 lar mechanisms that regulate region-specific enhancer activity in the developing brain.

208 Genome-wide quantification of enhancer activity in the human genome has proven to be a

209 conserved in therian mammals and capable of enhancer activity in the MBs.

210 tylation of histone 3 at lysine 27 (H3K27ac) enhancer activity in the regulatory regions of the assoc

211 system can also be used for the detection of enhancer activity in transient transgenesis.

212 P-DMRs located in INSR and CPT1A have enhancer activity in vitro and differential methylation

213 highly risk-associated SNPs and tested their enhancer activity in vitro, identifying three SNPs with

214 rrounding rs1143679 exhibits transcriptional enhancer activity in vivo and binds to Ku70/80, NFKB1 an

215 We propose a model for tissue-specific enhancer activity in which an HDAC-associated GLI repres

216 tify a sequence in the associated locus with enhancer activity in zebrafish somitic muscle and spinal

217 vity-regulated TFs and predefined epigenetic enhancer activity influences the anatomical diversity of

218 The mechanism of hsERVPRODH enhancer activity involves the binding of the transcript

219 This dichotomy of enhancer activity is conserved across different tissues,

220 We also showed that HBE enhancer activity is critically dependent on its interac

221 0 and Sall-1 in the emu wing, and the Sall-1 enhancer activity is dependent on a likely Fgf-mediated

222 sis of reporter constructs reveals that this enhancer activity is evolutionarily conserved among jawe

223 ther tissues shows that species-specific ERV enhancer activity is generally restricted to hypomethyla

224 ells from mouse fetal liver, suggesting that enhancer activity is highly dynamic during early hematop

225 EPHB3 enhancer activity is highly variable in colorectal carci

226 Regulation of enhancer activity is important for controlling gene expr

227 We also validate that enhancer activity is largely independent of orientation,

228 functional impact of these modifications on enhancer activity is not well understood.

229 Our finding that enhancer activity is often deeply conserved and frequent

230 s physically interact with target genes, how enhancer activity is regulated during development, and t

231 factors and super-enhancers, while additive enhancer activity isolates key genes involved in cell id

232 mic characteristics that correlate well with enhancer activity, it remains onerous to comprehensively

233 essed in CHF via inhibition of AT2R intronic enhancer activity, leading to lowered muscle regeneratio

234 examined the effects on gene expression and enhancer activity measured by histone 3 lysine 27 (H3K27

235 -scale manipulation and provide quantitative enhancer activity measurements across thousands of const

236 ifies the deep conservation of lamprey SoxE1 enhancer activity, mediating homologous expression in ja

237 Although CNS2 contains enhancer activity, methylated CpG sequences in this regi

238 onstructs of these BAC reporters to localize enhancer activity more precisely.

239 d transcription, transcriptional initiation, enhancer activity, non-methylated DNA, and transcription

240 genomic expanses, we have tested the in-vivo enhancer activity of 19 consecutive CSB clusters located

241 mong these candidates, motif-driven podocyte enhancer activity of CCNC and MEIS2 was functionally ana

242 Using a systematic, whole-genome analysis of enhancer activity of human-specific endogenous retrovira

243 The risk allele T of 1:g.98515539A>T reduced enhancer activity of its flanking sequence by >50% in hu

244 In contrast, the enhancer activity of PPARgamma binding sites depends on

245 duce Rgcc overexpression by potentiating the enhancer activity of Rgcc-E1 and Rgcc-E2.

246 Interestingly, the enhancer activity of Tf1 could be limited by Abp1, a hos

247 Baseline enhancer activity of the conserved region specifically o

248 and point mutations considerably reduced the enhancer activity of the intron 5 enhancer.

249 ragment near the insertion site and observed enhancer activity of this element in tissue culture cell

250 GAA motifs and thus the EWSR1-FLI1-dependent enhancer activity of this sequence, with epigenetic char

251 says in zebrafish to quantitatively test the enhancer activity of type 2 diabetes-associated loci.

252 The ability to modulate enhancer activity offers an additional layer of complexi

253 KX2.2 in NPCs was sufficient to induce Sox10 enhancer activity, OPC mRNA, and protein expression cons

254 ained unclear how frequently mutations alter enhancer activity or create functional enhancers de novo

255 located upstream of critical genes and have enhancer activity, other sLTRs are located within intron

256 ampal progenitors caused an increase in Cux2 enhancer activity outside the cortical hem.

257 riants, we explore patterns of developmental enhancer activity, predict molecular mechanisms, and ide

258 ive enhancer assay, to determine genome-wide enhancer activity profiles for five Drosophila species i

259 sult in distinct chromatin accessibility and enhancer activity profiles that differentially shape the

260 These alterations in enhancer activity provide a mechanism for how MeCP2 disr

261 lated by multiple enhancers, coordination of enhancer activities remains poorly understood.

262 elationship between primary DNA sequence and enhancer activity remains obscure.

263 t on transcription factor (TF) occupancy and enhancer activity remains poorly understood.

264 The enhancer activity requires sustained Hh signaling.

265 Notably, the precocious patterns of enhancer activity resemble the wild-type patterns that o

266 egulatory PAX6 binding site, causing loss of enhancer activity, resulting in defective maintenance of

267 urate analysis of transcription dynamics and enhancer activities simultaneously in both low-input and

268 oes not affect other molecular indicators of enhancer activity, suggesting that eRNA production occur

269 Importantly, Pro1 displays strong enhancer activity, suggesting that this may be its princ

270 Transcription is less predictive for enhancer activity than epigenetic modifications such as

271 and hypothyroidism has significantly greater enhancer activity than the allele associated with thyroi

272 also detect sequences with the potential for enhancer activity that are located in inaccessible, clos

273 tone modification alterations and changes in enhancer activity that correlated with gene expression.

274 y rs1635852 displayed allelic differences in enhancer activity; the type 2 diabetes risk allele T sho

275 genetic predisposition that reinforces PEAR1 enhancer activity through allele-specific DNA methylatio

276 s provide new insight into how regulation of enhancer activity through DNA methylation can have drama

277 Notably, we found that E93 controls enhancer activity through three different modalities, in

278 A factors act continuously, guarding hepatic enhancer activity throughout adult life.

279 of nearby B-cell lineage genes by impairing enhancer activity, thus causing defects in B-cell differ

280 scent 5' ends, we show that transfer of full enhancer activity to a target promoter requires both the

281 ion of functional genomics datasets spanning enhancer activity, transcription factor binding, express

282 The dynamic enhancer activities uncovered in this study illuminate r

283 ted 4796 enhancer SNPs capable of disrupting enhancer activity upon allelic change.

284 rter assays, two new sites display decreased enhancer activity upon mutation.

285 Thus, interference between enhancer activities was a possible factor necessitating

286 also show, using the Gitr promoter, that the enhancer activity was further upregulated in conjunction

287 Importantly, +286/+690 enhancer activity was suppressed in CHF mouse skeletal m

288 n sequence in mouse embryonic stem cells for enhancer activity we identified enhancers at pluripotenc

289 To explore the mechanism of allosteric enhancer activity, we examined their action on several A

290 Variants observed to alter enhancer activity were further confirmed to cause polyda

291 with accessible chromatin regions that lack enhancer activity, were enriched for enhancer RNAs (eRNA

292 itors that induces and maintains OCT4 distal enhancer activity when applied directly to conventional

293 ancers characterized in this study exhibited enhancer activity which may be modulated by DNA methylat

294 with increased transcription elongation and enhancer activity, which together lead to exceptionally

295 as an enhancer "brake" to ensure appropriate enhancer activity, which, when compromised, could contri

296 The risk variant of two sequences decreased enhancer activity, while in another two incremented it.

297 595104, which displayed dramatically reduced enhancer activity with the AF risk allele.

298 n expression was mostly due to non-classical enhancer activity within the intron, and movement of put

299 lowed us to probe a large genomic region for enhancer activity without assumptions on sequence conser

300 nscription in ES cells by directly affecting enhancer activity without requiring a change in transcri