ライフサイエンスコーパス: enhancer element

1 DNA chemistry without activation by the Fis/enhancer element.

2 moters of PHLDB1 and DDX6, and in a putative enhancer element.

3 and recruitment of FOXA1 and ERalpha to the enhancer element.

4 (EF1alpha) promoter and a strong endothelial enhancer element.

5 e transcription factor activating this Wnt9a enhancer element.

6 activator, CRM2 the repressor, and CRM3 the enhancer element.

7 and have excised an entire lincRNA gene and enhancer element.

8 the histone modifications associated with an enhancer element.

9 ns as a Pcdhalpha cluster-wide transcription enhancer element.

10 clusion via binding to a downstream intronic enhancer element.

11 via the activity of an RBPJ-dependent Nodal enhancer element.

12 direct binding of PAL-1 in vivo to an hlh-1 enhancer element.

13 ontaining SOX9 binding sites from the COL2A1 enhancer element.

14 of the molecular events on a Hpo-responsive enhancer element.

15 1beta is mediated through a complex intronic enhancer element.

16 1.54 x 10(-38)), and residing in a predicted enhancer element.

17 gulated by EWS/FLI via a GGAA microsatellite enhancer element.

18 d tPA gene expression via a STAT1-responsive enhancer element.

19 hown many variants are found within putative enhancer elements.

20 e modifications that typify active genes and enhancer elements.

21 apped with GRO-cap signal over both TSSs and enhancer elements.

22 ene expression through spatial clustering of enhancer elements.

23 ability to bind gamma-activated sequence DNA-enhancer elements.

24 omatin accessibility, particularly at distal enhancer elements.

25 via dynamic regulation of its cis-regulatory enhancer elements.

26 activity depending on the integrity of core enhancer elements.

27 sage-sensitive genes being more connected to enhancer elements.

28 2 and Akt1 coordinately recruit other TFs to enhancer elements.

29 ng at erythroid genes and at known erythroid enhancer elements.

30 9 promoters and their shared tissue-specific enhancer elements.

31 growth, suggesting that these regions act as enhancer elements.

32 om heterogeneity of functional signatures in enhancer elements.

33 istal promoter to identify the IMCD-specific enhancer elements.

34 of an inserted transgene cassette containing enhancer elements.

35 isplay many of the hallmarks associated with enhancer elements.

36 ariants frequently lie in cell-type-specific enhancer elements.

37 ranscriptional control of their own promoter/enhancer elements.

38 of thousands of CpG sites overlapping distal enhancer elements.

39 arget genes at high levels without exogenous enhancer elements.

40 ing with stage-specific activity of multiple enhancer elements.

41 events occur predominantly within regulatory enhancer elements.

42 eraction with the ETS-related ERG protein at enhancer elements.

43 utative target genes for known and predicted enhancer elements.

44 nteractions between gene promoters and their enhancer elements.

45 de new insight into the relationship between enhancer elements.

46 terations in DNA-methylation specifically in enhancer elements.

47 o be regulated by endogenous CD40LG promoter/enhancer elements.

48 sion of nearby genes via strong promoter and enhancer elements.

49 Here we demonstrate the utility of enhancer elements [422 (DlxI12b), Lhx6, 692, 1056, and 1

50 variant (P = 5.30 x 10(-25)), resides in an enhancer element 47 kb upstream of the transcription sta

51 expressing Lac-Z under the regulation of an enhancer element 9.7 kb upstream of the Irf6 start site,

52 Our results establish OL as a multifaceted enhancer element, able to activate transcription from lo

53 Finally, we show that E2A binds to enhancer elements across the FOXO1 locus to activate Fox

54 pstream regulators and segmental activity of enhancer elements across these distant species.

55 We provide evidence that small enhancer elements active in protodomains integrate broad

56 ntially co-amplified with its two endogenous enhancer elements active in the cell type of origin.

57 polymorphisms in LD that map to clusters of enhancer elements active in the same cell type.

58 In addition to mutations in genes, aberrant enhancer element activity at non-coding regions of the g

59 both RNA synthesis and stability as well as enhancer element activity following exposure to IR.

60 ne regulation in which spatial clustering of enhancer elements acts as a unified mechanism for both e

61 red homology, or presence of a recombination enhancer element adjacent to a donor.

62 de maps of histone modifications that reveal enhancer elements after 72 hr of in vitro polarization t

63 ncers, including the Nodal-proximal epiblast enhancer element and enhancer regions controlling Otx2 a

64 hat the change creates a new exonic splicing enhancer element and increases the amount of full-length

65 -mediated ALDH1A1 expression through a super-enhancer element and its associated enhancer RNA.

66 bition of ALDH1A1 expression through a super-enhancer element and other stem-related genes in promote

67 that Mysm1 directly associates with the Gfi1 enhancer element and promotes its transcription through

68 ally, causal variant rs7198799 resides in an enhancer element and remotely regulate ZFP90 expression

69 sults demonstrate robust effects of both the enhancer element and SNP rs5758550 on CYP2D6 expression,

70 TOR Y (NF-Y) binds a CCAAT box in the distal enhancer element and that CCAAT disruption dramatically

71 n Emu is a combination of both a 220-bp core enhancer element and two 310-350-bp flanking scaffold/ma

72 Moreover, we observe ectopic H3K9me3 at enhancer elements and an increased number of small RNAs

73 n-coding elements, many of which function as enhancer elements and are hypothesised to be under evolu

74 Also, DMSs were overrepresented in enhancer elements and enriched in enhancers that become

75 We further identify stage-specific distal enhancer elements and find enriched DNA binding motifs w

76 ed hCD79b promoter along with its associated enhancer elements and first exon could be deleted withou

77 locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop

78 ne under the control of human MnSOD promoter-enhancer elements and investigated the changes of MnSOD

79 The site lies close to Ubx enhancer elements and is also close to the locations of

80 regulated network is activated when AR binds enhancer elements and modulates specific enhancer-promot

81 Accumulating evidence implicates both enhancer elements and noncoding RNAs in controlling this

82 ation, when in chromosomal translocations Ig enhancer elements and oncogenes appear in a novel genomi

83 Transcription factors bind to enhancer elements and recruit coactivators and chromatin

84 scription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much

85 methylation of specific NF-kappaB-responsive enhancer elements and the activation of iNOS transactiva

86 with promoters showed strong enrichment for enhancer elements and validated several previously known

87 ranscription in the presence of the intronic-enhancer element, and this effect is dependent on nuclea

88 eling of neuronal processes, easy cloning of enhancer elements, and efficient and flexible generation

89 Thus, heterochronic enhancer elements, and their associated transcripts, are

90 riants for ER(-) tumors lie in four separate enhancer elements, and their risk alleles reduce express

91 three-dimensional organization of the genes, enhancer elements, and transcription machinery plays an

92 Enhancer elements are a key regulatory feature of many i

93 Enhancer elements are essential for tissue-specific gene

94 Enhancer elements are genomic regulatory sequences that

95 Distal enhancer elements are key drivers of spatiotemporal spec

96 Although enhancer elements are known to be associated with certai

97 Here, we show that multiple enhancer elements are present within this region and tha

98 arget genes are activated or repressed, what enhancer elements are required for regulation, and how d

99 Gene enhancer elements are thought to exist in either active

100 These data highlight the role of enhancer elements as mediators of T2D risk in humans, st

101 represents a different class of translation enhancer element, as defined by its structure and abilit

102 xonic or intronic RNA regulatory silencer or enhancer elements, as well as in genes that encode splic

103 dependent GWAS signals at 9p22.2 both within enhancer elements, as well as within a nuclear scaffold/

104 me conformation capture, we demonstrate that enhancer elements associate not just in linear sequence,

105 se studies have identified a cancer-specific enhancer element at the 8q24 gene desert that controls t

106 ding regions within evolutionarily conserved enhancer elements at +35 and +37 kb relative to the gene

107 We report here de novo formation of putative enhancer elements at CG hypomethylated sites that can be

108 s and exemplarily validated novel downstream enhancer elements at the CD14 locus.

109 Fs), such as NF-kappaB/Rel, are recruited to enhancer elements before the observed losses in methylat

110 sponsive region to the "osteoblast-specific" enhancer element between -420 and -350 bp that contains

111 We show that shuffling of existing enhancer elements both within and between species provid

112 Here, we have globally analyzed enhancer elements bound by IL-2-activated STAT5 and IL-2

113 modifications at both active and poised gene enhancer elements but also raise the possibility that en

114 s) are mediators of this defense with shared enhancer elements but display a spectrum of transcriptio

115 re correlated with transcriptionally engaged enhancer elements, but the functional impact of these mo

116 ne increased the occupancy of the identified enhancer element by RXRalpha, RARbeta, cJun, cFos, and p

117 s driven through a highly conserved intronic enhancer element by the transcription factors PAX3 and F

118 Thus, we defined thousands of candidate enhancer elements by incorporating these features, and f

119 dynamic regulation of specific cis Cd8 gene enhancer elements by positive selection signals in the t

120 networks and complementary sets of candidate enhancer elements by using single-cell RNA-seq to decomp

121 for directly identifying active promoter and enhancer elements called FIREWACh (Functional Identifica

122 taposed to active immunoglobulin heavy chain enhancer elements, chromosomal aneuploidy, somatic mutat

123 are regulated by clusters of Mediator-bound enhancer elements collectively referred to as super-enha

124 ugh the majority of our current knowledge of enhancer elements comes from detailed analyses of indivi

125 rpoS expression without an apparent upstream enhancer element commonly associated with other sigma(54

126 ivate a PMP22 (peripheral myelin protein 22) enhancer element compared to wild-type EGR2.

127 more than twice the number of hypomethylated enhancer elements compared with myoepithelial cells.

128 (+) T cells were unable to activate "poised" enhancer elements compared with wild-type CD8(+) T cells

129 dentified a physical interaction between the enhancer element containing a functional SNP (rs73001406

130 at are regulated by a remote recombinational enhancer element containing two binding sites for the pr

131 uishes active enhancers from inactive/poised enhancer elements containing H3K4me1 alone.

132 modulates YY1 binding and the activity of an enhancer element controlling the autoimmune-associated I

133 emonstrate that PAX8 largely occupies active enhancer elements controlling genes involved in various

134 Thus targeting intron 2 enhancer element could lead to the development of a nove

135 -seq and ChIP-seq, that specific Runx1-bound enhancer elements critically modulate lineage-dependent

136 KLK3e carries the core enhancer element derived from the androgen response elem

137 xon 11 inclusion, which requires an intronic enhancer element downstream of exon 11.

138 RNA binding assays demonstrated that the enhancer element downstream of PKCdelta exon 10 is a SC3

139 nscription factors and deletion of a pivotal enhancer element dramatically decreases CFTR expression,

140 hat reproducible changes in the epigenome at enhancer elements drive a specific transcriptional progr

141 lele enables enhanced activities of upstream enhancer elements due to loss of Sp1 binding at the poly

142 to a more accessible chromatin structure at enhancer elements early during reprogramming.

143 ort of this hypothesis, we identify a distal enhancer element, ECR1, which is active in developing ur

144 sequence-specifically to ER stress response enhancer elements (ERSEs) in their promoter-regulatory r

145 netic observations, NR2F2 directly activated enhancer elements flanking cell cycle genes to drive the

146 gradation of RNA and monitor the activity of enhancer elements following exposure to IR, we used the

147 n-coding genomic region containing an active enhancer element for CTSB, resulting in upregulation of

148 ) insertion site effects or (ii) deletion of enhancer elements for class switch recombination and tra

149 ly characterize previously described and new enhancer elements for their roles in the embryonic stem

150 Here, we analyze an enhancer element from the even skipped (eve) gene, which

151 A transcriptional enhancer element from the Mason-Pfizer monkey virus can

152 ntified numerous such colocated boundary and enhancer elements from human CD4(+) T cells.

153 SJL genetic content affected enhancer elements, gene regulation, protein expression,

154 new approach for identifying TSSs and active enhancer elements genome-wide in intact cells.

155 on of chromatin accessibility within TSS and enhancer elements gradually decreased as cells progresse

156 nical gene therapy trials, although powerful enhancer elements have caused insertional mutagenesis an

157 where NF-Y complexes, bound at the FT distal enhancer element, help recruit CO to proximal cis-regula

158 inding sites was identified within a distant enhancer element (HS5-1), which is required for normal l

159 Here we show that two transcriptional enhancer elements, HS5-1 and HS7, play a critical role i

160 h-6, but mutagenesis of a short male gonadal enhancer element in egl-5 suggested that this regulation

161 ach to delete 475 and 663 bp of the putative enhancer element in HEK293T kidney cells; compared to ex

162 on with restored occupancy of a sex-specific enhancer element in principal downstream gene Sox9, demo

163 recently evolved polymorphism within a super-enhancer element in the first intron of LMO1 influences

164 We show that evolution of an enhancer element in the homeobox gene REDUCED COMPLEXITY

165 th protein forms of PAX6 bind directly to an enhancer element in the MET promoter and activate the ex

166 in endothelial cells (ECs) by binding to an enhancer element in the Vegfr3 gene.

167 We re-sequenced these enhancer elements in a cohort of non-syndromic patients

168 Our integrated analysis of enhancer elements in a large series of primary tumour sa

169 A genome-wide epigenetic analysis of enhancer elements in colon cancer has implicated distal

170 to identify sequence variation in genes and enhancer elements in congenic and backcross mouse models

171 RNA turnover and did not address the role of enhancer elements in DDR-mediated transcriptional regula

172 e we interrogate the epigenetic landscape of enhancer elements in embryonic stem cells and several ad

173 Furthermore, we observe that p53 is bound to enhancer elements in healthy fibroblasts and poised for

174 Identifying functional enhancer elements in metazoan systems is a major challen

175 Regulatory enhancer elements in solid tumours remain poorly charact

176 eER(T2) and GFP expression from 14 different enhancer elements in stable transgenic mice allowed us t

177 , mapping the activity of cell-type-specific enhancer elements in T helper 1 (Th1) and Th2 cells.

178 lls and those activated in vivo, Foxp3-bound enhancer elements in the DNA were poised for repression

179 ecognition, and is dependent on the scanning enhancer elements in the eIF1A CTT.

180 Enhancer elements in the human genome control how genes

181 Both the strong promoter/enhancer elements in the long terminal repeats (LTRs) of

182 ), which bind preferentially to promoter and enhancer elements in the mammalian genome.

183 n state and promotes the formation of active enhancer elements in the non-coding genome, leading to a

184 ciation of the p65 subunit of NF-kappaB with enhancer elements in the Nos2 promoter but had little ef

185 t WT CLOCK protein interacted with the E-box enhancer elements in the promoters of the proline hydrox

186 sequence specifically to ER stress response enhancer elements in their promoters.

187 or GFI1B coding sequences proximal to active enhancer elements, including super-enhancers, instigatin

188 oter regions and instead localizes to distal enhancer elements, including those that regulate the act

189 Finally, BruUV-seq identified putative enhancer elements induced by tumor necrosis factor (TNF)

190 t long-distance chromatin loops bring distal enhancer elements into close association with the proxim

191 We find that the same enhancer element is also a target of HLH-1 positive auto

192 This enhancer element is consistently present in sortilin RNA

193 The crystal structure of a sex-specific enhancer element is described at a resolution of 1.6 A.

194 This distal enhancer element is observed in the homologous mouse gen

195 Epigenetic regulation of gene enhancer elements is important for establishing and main

196 between signaling pathways and actively used enhancer elements is not clear.

197 the functional importance of these clustered enhancer elements is poorly understood, so it is not cle

198 ene juxtaposes the coding sequence to strong enhancer elements, leading to TERT overexpression and po

199 L2 neurons via internal promoters and remote enhancer elements located in introns of the daf-19 genom

200 and the retinoic acid (RA) receptor via two enhancer elements located upstream of the gene.

201 The recognition and activation of enhancer elements located within inaccessible chromatin

202 We identified a new regulatory enhancer element, located within the RUNX2 gene, which i

203 y generated global maps of poised and active enhancer elements marked by histone H3 lysine 4 monometh

204 These mutational enhancer elements (MEEs) are required over and above tra

205 e that common genetic variants in long-range enhancer elements modulate the immediate transcriptional

206 the presence of conserved ERG-bound putative enhancer elements near these target genes.

207 atin analysis showed that FoxP3 bound active enhancer elements, not repressed chromatin, around loci

208 Previous work identified the occludin enhancer element (OEE) as a GC-responsive cis-element in

209 GFP under the control of a cardiac-specific enhancer element of Nkx2-5, a transcription factor expre

210 This region, which comprises the distal enhancer element of P1-rr, is hypermethylated in P1-pr c

211 The CAR directly binds to the distal enhancer element of the CYP2B6 promoter, which is essent

212 or that interacts with an essential upstream enhancer element of the EKLF promoter and exerts a posit

213 es with the histone demethylase Jmjd3 at the enhancer element of the Eomes locus to allow enhancer-pr

214 We identified a new enhancer element of this second class, ECR111, which is

215 exes was diminished by mutations of scanning enhancer elements of eIF1A that increase near-cognate re

216 part by recruiting to the ER stress response enhancer elements of ER stress response genes a collecti

217 so we have explored the potential of distal enhancer elements of non-coding RNAs in the prognosticat

218 We also identified promoter and enhancer elements of the human ITGAE gene, encoding CD10

219 Smad proteins, and we have mapped a putative enhancer element on the SIK1 gene.

220 eved and regulated, and suggests that distal enhancer elements, once appropriately positioned at the

221 ethylation (me2/3) (which we name H3K79me2/3 enhancer elements or KEEs) can be found in multiple cell

222 We also demonstrate that one such enhancer element physically interacts with the Myc promo

223 ts reveal that the DHS-35kb airway-selective enhancer element plays a pivotal role in regulation of C

224 poietic progenitors, multilineage priming of enhancer elements precedes commitment to the lymphoid or

225 we characterized an evolutionarily conserved enhancer element present in multiple zinc-inducible gene

226 nist-bound receptor was recruited to several enhancer elements proximal to the E2F1 transcript.

227 These features are similar to those of gene enhancer elements, raising the possibility that CHD7 fun

228 ovide experimental evidence of a replication enhancer element (REE) within the capsid gene of tick-bo

229 Genomic enhancer elements regulate gene expression programs impo

230 How distant enhancer elements regulate the assembly of a transcripti

231 Ps is that they would affect the activity of enhancer elements regulating critical target genes.

232 pings involving proximal promoter and distal enhancer elements regulating GABAergic gene expression,

233 ter deletion analysis further indicates that enhancer elements required for BP expression in the leaf

234 juxtapose the TERT coding sequence to strong enhancer elements, resulting in massive chromatin remode

235 and histone modification-based definition of enhancer elements revealed intragenic enhancer methylati

236 reporter under the control of the human IRF6 enhancer element showed high expression of IRF6 in major

237 31746 mapped to a long-range neuron-specific enhancer element shown previously to regulate PCDH-alpha

238 ritically, methylation treatment of the iNOS enhancer element significantly decreased its activity in

239 The HMPS duplication contains predicted enhancer elements; some of these interact with the GREM1

240 vity to distinctive gene subsets in a kappaB enhancer element-specific context.

241 The enhancer element-specific histone H3K4me1/2 mark is enri

242 lymorphisms are frequently positioned within enhancer elements specifically active in relevant cell t

243 Using epigenomic methods, we characterized enhancer elements specifically modified in differentiati

244 We describe three enhancer elements sufficient for endothelial gene expres

245 deregulated genes reside in the vicinity of enhancer elements, suggesting that cohesin regulates gen

246 -distal RNA polymerase II (RNAP2) binding at enhancer elements, suggesting that these interactions ma

247 of this long-range action, the annotation of enhancer element-target promoter pairs remains elusive.

248 nly one causal SNP in the region and several enhancer elements targeting STXBP4 are located within th

249 s noted above, the Total Functional Score of Enhancer Elements (TFSEE) identified key breast cancer s

250 isolated a 258 bp cross-species PC-specific enhancer element that can be used in a bidirectional man

251 78) maps to 15q21.3 and overlaps a noncoding enhancer element that contains multiple activator protei

252 In this work, we characterize an enhancer element that drives Myf5 expression in the bran

253 Therefore, we sought to identify an Otx2 enhancer element that functions in photoreceptor develop

254 factor 7-like 2-dependent (TCF7L2-dependent) enhancer element that functions to increase SHROOM3 tran

255 erlapping region of these duplications is an enhancer element that is active in epidermal keratinocyt

256 in chick Nkx2.5 binds directly to a genomic enhancer element that is required to maintain Nkx2.5 exp

257 demonstrated that SNP rs10941679 maps to an enhancer element that physically interacts with the FGF1

258 093 CCV at this region was located within an enhancer element that physically interacts with the NTN4

259 al coregulator, Hcf-1, to a highly conserved enhancer element that previously lacked a recognized bin

260 sociated risk variant in a non-coding distal enhancer element that regulates the expression of alpha-

261 We identified a specific splicing enhancer element that regulates the inclusion of a sorti

262 dicates that these SNPs localise to putative enhancer elements that bind known drivers of hormone-dep

263 ge cohort of preestablished, promoter-distal enhancer elements that demonstrates dynamic histone acet

264 adaptation defined by the activity of distal enhancer elements that drive expression of 5' Hoxd genes

265 atterning TFs regulate the activity of small enhancer elements that drive gene expression in pallial

266 n regulated by the action of transcriptional enhancer elements that function in an orientation-indepe

267 Here, we identified DNA enhancer elements that mediate intestine-specific transc

268 th this method, we isolated 100 bp synthetic enhancer elements that were as potent at activating tran

269 nstrate in this study that it is the four 3' enhancer elements themselves (a total of 4.7 kb) that ar

270 uclear factor 4alpha) with CAR at the distal enhancer element to activate the promoter.

271 ich sites within the nominal single-stranded enhancer element to form a high-affinity 2:1 protein:DNA

272 erapy field, which aim to incorporate weaker enhancer elements to avoid insertional mutagenesis.

273 Here, we investigate the contribution of enhancer elements to cisplatin resistance in ovarian can

274 s converges on specific and highly essential enhancer elements to drive the function of a cell-type-d

275 CTCF was shown to restrict activity of kappa enhancer elements to the Ig kappa locus.

276 ctroporation together with Atoh1 and Neurog1 enhancer elements to visualize, and assess the consequen

277 lows distally located provirus, with its own enhancer elements, to access the 5' regulatory region of

278 To identify candidate tissue regeneration enhancer elements (TREEs) important for zebrafish fin re

279 ies on the activities of tissue regeneration enhancer elements (TREEs); however, the mechanisms under

280 gs provide evidence for 'tissue regeneration enhancer elements' (TREEs) that trigger gene expression

281 We identified a putative enhancer element upstream of the key lymphatic transcrip

282 We previously identified an enhancer element upstream of the mouse cd5 gene that was

283 An enhancer element upstream of the mouse Gata1 IE (1st exo

284 This enhancer element was transactivated by cotransfection wi

285 To characterize the CYP2D6 enhancer element, we applied chromatin conformation capt

286 V) were constructed in which strong promoter/enhancer elements were used to drive expression of simia

287 , the H3K9me2 modification extends to active enhancer elements where it promotes developmentally-link

288 buted to transcription factors that bind DNA enhancer elements, which are often located far from gene

289 T inhibition to the association of Brd4 with enhancer elements, which tend to be involved in lineage-

290 The mutation is located in a long-range enhancer element whose ability to bind the transcription

291 express CreER(T2) and GFP from ten different enhancer elements with activity in distinct domains with

292 pective of conserved functionality: putative enhancer elements with ancient sequence age (older than

293 the PDZK1IP1 protein shared transcriptional enhancer elements with the blood stem cell regulator TAL

294 We find that differential DNA methylation at enhancer elements, with concurrent changes in histone mo

295 rough a Stat92E-modulated, injury-responsive enhancer element within the draper gene.

296 Genomic mapping identified an enhancer element within the first intron of the NUAK2 ge

297 that beta-catenin/TCF4 complexes bind a DNA enhancer element within the first intron of the YAP gene

298 epeat, termed R0, that can function as a DNA enhancer element within the intronic sequences of Firre.

299 state and site specific DNA demethylation of enhancer elements within the proximal promoters of AREG

300 We have previously identified cis-acting enhancer elements within the proximal upstream genomic r