ライフサイエンスコーパス: enteroendocrine cell

1 TRPA1 to excite primary sensory neurons and enteroendocrine cells.

2 g progeny that replace dying enterocytes and enteroendocrine cells.

3 he development of both pancreatic islets and enteroendocrine cells.

4 l enterocytes, as well as goblet, Paneth and enteroendocrine cells.

5 level of constitutive expression of NT/N in enteroendocrine cells.

6 and of preproglucagon, which is expressed in enteroendocrine cells.

7 signaling, specify their daughters to become enteroendocrine cells.

8 , including Paneth and goblet cells, but not enteroendocrine cells.

9 ge analysis to generate both enterocytes and enteroendocrine cells.

10 inal cell populations, including a subset of enteroendocrine cells.

11 y generalized malabsorption and a paucity of enteroendocrine cells.

12 lycan expression and a paucity of goblet and enteroendocrine cells.

13 , have fewer goblet cells, and supernumerary enteroendocrine cells.

14 quired to produce an appropriate fraction of enteroendocrine cells.

15 but are interspersed with hormone-producing enteroendocrine cells.

16 egulatory elements are not active in gastric enteroendocrine cells.

17 cosal T lymphocytes and serotonin-containing enteroendocrine cells.

18 or activator binding in islet beta-cells and enteroendocrine cells.

19 rminal differentiation of secretin-producing enteroendocrine cells.

20 receptors are expressed, at least partly, in enteroendocrine cells.

21 g in white adipocytes and various immune and enteroendocrine cells.

22 certain other hormones in other types of the enteroendocrine cells.

23 symmetric at midpupal development to produce enteroendocrine cells.

24 ntrast to canonical gut hormones produced in enteroendocrine cells.

25 ric metaplasia with significant reduction in enteroendocrine cells.

26 ic islets, adipocytes, endothelial cells and enteroendocrine cells.

27 A1), a Ca(2+)-permeable channel expressed in enteroendocrine cells.

28 engineered HIOs with an increased number of enteroendocrine cells.

29 e in enterocytes, and both TrpA1 and Dh31 in enteroendocrine cells.

30 proteins are bioactive, nor their effects on enteroendocrine cells.

31 reprogram extant class I cells into class II enteroendocrine cells.

32 A2 and FFA3 were immunolocalised to duodenal enteroendocrine cells.

33 tty acids (LCFAs) and SCFAs are expressed in enteroendocrine cells.

34 d in the infection of mucosal nerves through enteroendocrine cells.

35 teria stimulate epithelial biosensors called enteroendocrine cells.

36 innervated sensory epithelial cells, such as enteroendocrine cells.

37 hormones until the discovery of synapses in enteroendocrine cells.

38 eages: intermediate-like (Paneth/goblet) and enteroendocrine cells.

39 iously unrecognized tissue-intrinsic role of enteroendocrine cells.

40 or the normal development of mouse and human enteroendocrine cells.

41 However, we recently uncovered in intestinal enteroendocrine cells a cytoplasmic process that we name

42 Here we report a novel function of enteroendocrine cells acting as local regulators of inte

43 s requires sensing of meal components by gut enteroendocrine cells, activation of neural and humoral

44 are incretins secreted by respective K and L enteroendocrine cells after eating and amplify glucose-s

45 er mechanical forces, specifically activates enteroendocrine cells among all epithelial cell types.

46 nd -3 are upregulated by oxidative stress in enteroendocrine cells and activate JAK-STAT signaling in

47 focal immunohistochemistry with serotonin in enteroendocrine cells and also with endothelial nitric o

48 nd unexpected diversity in hormone-secreting enteroendocrine cells and constructed the taxonomy of ne

49 late GLP-1 and GIP secretion from intestinal enteroendocrine cells and increase GSIS from pancreatic

50 t T2R gene expression in both cultured mouse enteroendocrine cells and mouse intestine is regulated b

51 by biologic agents produced and released by enteroendocrine cells and neurons as well as by exogenou

52 europods provide a direct connection between enteroendocrine cells and neurons innervating the small

53 a small number of cell types, including gut enteroendocrine cells and sympathetic ganglia, where it

54 s on endogenous enteric hormones produced by enteroendocrine cells and the enteric nervous system.

55 Peptide YY(+) cells gave rise to all L-type enteroendocrine cells and to islet partial differential

56 FFA3 was immunolocalized to enteroendocrine cells and to the enteric neural plexuses

57 +) cells from Bmi1(GFP) mice are preterminal enteroendocrine cells and we identify CD69(+)CD274(+) ce

58 ocrine-cell progenitors differentiating into enteroendocrine cells, and (2) switching on the expressi

59 usion casein proteins are not detrimental to enteroendocrine cells, and alpha and beta casein are par

60 (NPS), is expressed by gastrointestinal (GI) enteroendocrine cells, and is involved in inflammation,

61 atase in brush border and more goblet cells, enteroendocrine cells, and Paneth cells.

62 of these results showed higher expression of enteroendocrine cells, and the proliferating cell marker

63 HRVs infect differentiated enterocytes and enteroendocrine cells, and viroplasms and lipid droplets

64 The abnormalities in the ileal enteroendocrine cells appear to be caused by two mechani

65 IBS), and whether any abnormalities in ileal enteroendocrine cells are correlated with abnormalities

66 Intestinal enteroendocrine cells are critical to central regulation

67 Despite being electrically excitable, enteroendocrine cells are generally thought to communica

68 5HT-containing enteroendocrine cells are most numerous in the duodenum

69 Enteroendocrine cells are one of the four major cell typ

70 although goblet cells resist E11 infection, enteroendocrine cells are permissive, suggesting that en

71 Enteroendocrine cells are specialised sensory cells loca

72 Enteroendocrine cells are specialized sensory cells of t

73 three secretory lineages, goblet, paneth, or enteroendocrine cells, are not fully understood.

74 We show that goblet, Paneth, and enteroendocrine cells arise by multilineage priming in c

75 r results indicate that all small intestinal enteroendocrine cells arise from ngn3-expressing cells a

76 ondin domain-containing protein expressed in enteroendocrine cells as well as in epithelial cells in

77 rminal differentiation of the pancreatic and enteroendocrine cells, as well as for the survival of ph

78 In the intestine, Pak3 is expressed in enteroendocrine cells but is not necessary for their dif

79 Transformation of secretin-producing enteroendocrine cells by SV40 requires functional cooper

80 We find that class I and class II enteroendocrine cells can be distinguished locally by co

81 acetate induces chromatin remodeling within enteroendocrine cells, co-regulating host metabolism and

82 Here, we show that enteroendocrine cells coordinate stem cell migration tow

83 me transcription factors as their intestinal enteroendocrine cell counterparts.

84 an jejunal enteroids engineered to make more enteroendocrine cells demonstrated that Hld alone is suf

85 ssociated with reduced expression of PYY, an enteroendocrine cell-derived hormone that normally inhib

86 , is both necessary and sufficient for human enteroendocrine cell development in vitro.

87 To understand the molecular basis of enteroendocrine cell development, we have used gene targ

88 g that Arx is required in the progenitor for enteroendocrine cell development.

89 eurogenin 3 stimulated a program of terminal enteroendocrine cell development.

90 Neurogenin 3 is essential for enteroendocrine cell development; however, it is unknown

91 RB has relatively subtle effects on enteroendocrine cell differentiation and is not required

92 f the beta-catenin gene at an early stage of enteroendocrine cell differentiation induced small-intes

93 nin-3 overexpression induced goblet cell and enteroendocrine cell differentiation, respectively, cons

94 teroblast lineage while inhibiting secretory enteroendocrine cell differentiation.

95 ed for intestinal secretory (goblet, Paneth, enteroendocrine) cell differentiation.

96 cellular and molecular mechanisms governing enteroendocrine cell diversity.

97 ngenital malabsorptive diarrhea secondary to enteroendocrine cell dysgenesis.

98 In obese patients, the total number of enteroendocrine cells (EEC) and EECs containing gut horm

99 e nutrients, where neuropeptides secreted by enteroendocrine cells (EEC) produce systemic signals in

100 ectal cancer (mCRC) is uniquely enriched for enteroendocrine cells (EEC), the neuroendocrine cells of

101 d microbial stimuli using epithelial sensory enteroendocrine cells (EEC).

102 can activate nutrient-sensitive receptors on enteroendocrine cells (EECs) and, when formulated as lip

103 Enteroendocrine cells (EECs) are crucial for sensing ing

104 Enteroendocrine cells (EECs) are dispersed throughout th

105 Enteroendocrine cells (EECs) are rare sensory cells in t

106 A population of enteroendocrine cells (EECs) are specialized mechanosens

107 Enteroendocrine cells (EECs) are specialized sensors of

108 Enteroendocrine cells (EECs) are specialized sensory cel

109 Enteroendocrine cells (EECs) are the principal chemosens

110 As enteroendocrine cells (EECs) comprise only ~1% of the in

111 ithelial cells, with chromogranin A-positive enteroendocrine cells (EECs) identified as a permissive

112 Specialized sensory enteroendocrine cells (EECs) in GI epithelium interact i

113 nin (CCK) and secretin, peptides released by enteroendocrine cells (EECs) in the duodenum/jejunum, wh

114 s of experiments collectively indicated that enteroendocrine cells (EECs) in the posterior midgut pro

115 The recent discovery that a subtype of enteroendocrine cells (EECs) known as neuropod cells syn

116 mmunodeficiency (IMD) pathway in a subset of enteroendocrine cells (EECs) of the anterior midgut.

117 ly processed and cleaved from proglucagon in enteroendocrine cells (EECs) of the intestinal tract, ac

118 ific cell type from the gut epithelium named enteroendocrine cells (EECs) possess many neuron-like pr

119 Enteroendocrine cells (EECs) produce hormones such as gl

120 Enteroendocrine cells (EECs) secrete hormones in respons

121 Enteroendocrine cells (EECs) secrete serotonin (enteroch

122 Enteroendocrine cells (EECs) sense intestinal content an

123 emistry showed major up-regulation of CCK in enteroendocrine cells (EECs) that were glucagon-like pep

124 y focuses on the increased activation of gut enteroendocrine cells (EECs), resulting in enhanced secr

125 atients are macroscopically normal, but lack enteroendocrine cells (EECs), suggesting an essential ro

126 Enteroendocrine cells (EECs), the neuroendocrine cell of

127 loric metaplasia cells can generate tuft and enteroendocrine cells (EECs).

128 d, in the absence of mucosal enterocytes and enteroendocrine cells (EECs).

129 dentify, genetically modify and purify human enteroendocrine cells (EECs).

130 senting intestinal stem cells, enteroblasts, enteroendocrine cells (EEs), and enterocytes.

131 urogenin3 (Neurog3)-expressing cells, unlike enteroendocrine cells elsewhere in the digestive tract.

132 Enteroendocrine cells engineered to secrete recombinant

133 ating glucagon-like peptide-1 secretion from enteroendocrine cells, enhancing glucose uptake in 3T3-L

134 pecialized elements of the mucosa (including enteroendocrine cells, enterocytes and immune cells) and

135 Gastrointestinal enteroendocrine cells express chemosensory bitter taste

136 Distinct subsets of enteric neurons and enteroendocrine cells expressed RET in the adult intesti

137 a cells, and for terminal differentiation of enteroendocrine cells expressing the hormone secretin.

138 ion, secretin- and cholecystokinin-producing enteroendocrine cells failed to develop in the absence o

139 n intestinotrophic growth factor released by enteroendocrine cells following food intake.

140 NA from three unrelated patients with sparse enteroendocrine cells for mutations of NEUROG3.

141 ed that our organoids contained enterocytes, enteroendocrine cells, goblet cells and Paneth cells.

142 nisms of nutrient sensing by enterocytes and enteroendocrine cells have been well established; howeve

143 The functions of enteroendocrine cells have classically been inferred by

144 mice to study neural circuits, we found that enteroendocrine cells have the necessary elements for ne

145 av1.8-expressing vagal afferents with select enteroendocrine cells (i.e., ghrelin, glucagon, GLP-1).

146 hat peptide profiles are a stable feature of enteroendocrine cell identity during homeostasis and fol

147 Intestinal enteroendocrine cells (IECs) secrete gut peptides in res

148 cell types, including enteric neurons, glia, enteroendocrine cells, immune cells and bacteria, integr

149 and molecular bridge between enteric nerves, enteroendocrine cells, immune cells, and epithelial cell

150 We describe a type of enteroendocrine cell in mouse duodenum that is defined b

151 xhibit greater than 90% decrease in tuft and enteroendocrine cells in both crypts and villi of the sm

152 We studied a subset of these enteroendocrine cells in duodenum that produce several p

153 We observed loss of Paneth, goblet, and enteroendocrine cells in Math1-null crypts.

154 Gastrointestinal peptides are secreted from enteroendocrine cells in response to nutrient and energy

155 stem cells that generate new enterocytes and enteroendocrine cells in response to tissue requirements

156 d relative densities of enterochromaffin and enteroendocrine cells in small intestinal tissue.

157 to conditionally delete Paneth, goblet, and enteroendocrine cells in the epithelium to investigate t

158 Enteroendocrine cells in the gastrointestinal tract play

159 redominantly in pancreatic beta-cells and in enteroendocrine cells in the gastrointestinal tract.

160 y participate in GABA-modulated functions of enteroendocrine cells in the GI lumen.

161 in-coupled receptor expressed by a subset of enteroendocrine cells in the gut epithelium.

162 ino acids from food acutely activate Dh31(+) enteroendocrine cells in the gut, increasing Dh31 levels

163 e of regulating peptide hormone release from enteroendocrine cells in the gut.

164 They are secreted from enteroendocrine cells in the intestinal epithelium follo

165 owed that the mechanoreceptor Piezo2 enables enteroendocrine cells in the intestinal epithelium to se

166 otropic polypeptide (GIP)) are secreted from enteroendocrine cells in the intestinal epithelium, and

167 nsmembrane receptor that is expressed in the enteroendocrine cells in the intestine and in the islets

168 ause GABArho receptors are normally found in enteroendocrine cells in the lumen of the digestive trac

169 Secretin-producing enteroendocrine cells in the murine small intestine show

170 peptide-1 (GLP-1) and peptide YY (PYY), from enteroendocrine cells in the small intestine.

171 ngn3 is required for the differentiation of enteroendocrine cells in the stomach and the maintenance

172 l of the abnormal epithelium, the numbers of enteroendocrine cells in the villi are greatly reduced.

173 ional genetics to enable selective access to enteroendocrine cells in vivo in mice.

174 ween Nav1.8-expressing mucosal afferents and enteroendocrine cells, including apparent neuroendocrine

175 ng nutrient sensing and peptide secretion by enteroendocrine cells, including novel taste-like pathwa

176 ymphocytes and goblet cells reduced, and the enteroendocrine cells increased.

177 blood flow, but the ENS also interacts with enteroendocrine cells, influences epithelial proliferati

178 of the ISC daughter cells differentiate into enteroendocrine cells instead of their initial enterocyt

179 erizing the roles and functions of different enteroendocrine cells is an essential step in understand

180 absorptive diarrhea and a lack of intestinal enteroendocrine cells is caused by loss-of-function muta

181 tificial pancreas based on insulin-secreting enteroendocrine cells is insufficient as a standalone th

182 Expression of the hormone secretin in enteroendocrine cells is restricted to the nondividing v

183 sulin release, are secreted from specialized enteroendocrine cells (L and K cells, respectively).

184 In addition, in the enteroendocrine cell line STC-1 and in the neuronal cell

185 kinin (CCK) secretion in humans and from the enteroendocrine cell line STC-1 depends critically on ac

186 ) and glucagon like peptide-1 (GLP-1) in the enteroendocrine cell line STC-1, and to evaluate the inv

187 Using the enteroendocrine cell line STC-1, the aim of this study w

188 Recently, we proposed that the murine enteroendocrine cell line, STC-1, responds to insoluble

189 ne, glucagon-like peptide (GLP-1), using the enteroendocrine cell line, STC-1.

190 receptors also was found in STC-1 cells, an enteroendocrine cell line.

191 eta and kappa casein) and hydrolysates on an enteroendocrine cell line.

192 cose homeostasis through a modulation of the enteroendocrine cell lineage.

193 s role in the development and maintenance of enteroendocrine cell lineages in the mouse duodenum and

194 ctively targeted major transcriptome-defined enteroendocrine cell lineages that produce serotonin, gl

195 cellular Ca2+ concentration ([Ca2+]i) in two enteroendocrine cell lines (STC-1 and GLUTag).

196 CK) secretion both in humans and from murine enteroendocrine cell lines.

197 The K cell is a specific sub-type of enteroendocrine cell located in the proximal small intes

198 r ATOH1, the goblet cell marker Muc2 and the enteroendocrine cell marker ChgA.

199 (ATOH1), the goblet cell marker Muc2 and the enteroendocrine cell marker ChgA.

200 s in a profound deficit in expression of the enteroendocrine cell markers CCK, secretin and glucagon

201 egatively regulating chromogranin A-positive enteroendocrine cell number.

202 Paneth, tuft, goblet, and enteroendocrine cell numbers were dependent on IL-17A-me

203 These include the release from enteroendocrine cells of mediators including 5HT, CCK, G

204 strictly agonist-dependent fashion whilst in enteroendocrine cells of the colon both Ser(296)/Ser(297

205 imals, nutrient sensors are found within the enteroendocrine cells of the digestive system; however,

206 Enteroendocrine cells of the gastrointestinal (GI) tract

207 -1 (GLP-1) is a signal peptide released from enteroendocrine cells of the lower intestine.

208 eurotensin (NT), a gut hormone released from enteroendocrine cells of the small bowel, contribute to

209 ptide predominantly localized in specialized enteroendocrine cells of the small intestine and release

210 pancreatic beta-cells and incretin-producing enteroendocrine cells of the small intestine.

211 reting copper cells, interstitial cells, and enteroendocrine cells of the stomach.

212 The transgene was not expressed in goblet or enteroendocrine cells or in crypts.

213 canonical Notch signaling, was restricted to enteroendocrine cells or undetectable in the mucosa of t

214 Our results suggest that RB is required for enteroendocrine cells, particularly serotonin cells, to

215 controlling incretin secretion, we analyzed enteroendocrine cell pathways important for hormone bios

216 stricted expression, including expression in enteroendocrine cells, pineal gland, and dental enamel.

217 Stimulus-coupled incretin secretion from enteroendocrine cells plays a fundamental role in glucos

218 Enteroendocrine cells populate gastrointestinal tissues

219 Nkx2.2 null mice, several hormone-producing enteroendocrine cell populations are absent or reduced a

220 s the differentiation of progressively fewer enteroendocrine cell populations when deleted from Ngn3(

221 The patients had few intestinal enteroendocrine cells positive for chromogranin A, but t

222 , goblet cells, Paneth cells, tuft cells and enteroendocrine cells), presence of functional brush-bor

223 proliferative and have increased numbers of enteroendocrine cells producing serotonin (also known as

224 examined whether the densities of stem- and enteroendocrine cell progenitors are abnormal in the ile

225 related with abnormalities in stem cells and enteroendocrine cell progenitors.

226 Beta casein significantly stimulated enteroendocrine cell proliferation and all caseins were

227 hows that optogenetic stimulation of Dh31(+) enteroendocrine cells rapidly excites a subset of brain

228 In response to injury, enteroendocrine cells release the N-terminal domain of t

229 n of the intestinal epithelium, and identify enteroendocrine cell-released ligands as critical coordi

230 Secretin-producing enteroendocrine cells represent a nondividing subpopulat

231 xis of the gastrointestinal system, discrete enteroendocrine cells respond to both mechanical and che

232 Enteroendocrine cells respond to digestion products of d

233 epithelium, enterochromaffin (EC) cells are enteroendocrine cells responsible for producing >90% of

234 mice, expression of NT in Drosophila midgut enteroendocrine cells results in increased lipid accumul

235 Loss of enteroendocrine cells reveals the critical need for ente

236 K) is a satiety hormone produced by discrete enteroendocrine cells scattered among absorptive cells o

237 Mechanistically, midgut enteroendocrine cells secrete the neuroendocrine hormone

238 ctivity mediated by LSD1 and CoREST2 induces enteroendocrine cell specification in mucinous colorecta

239 Although Nkx2.2 regulates enteroendocrine cell specification in the duodenum at al

240 cells, Paneth cells, tuft cells, and diverse enteroendocrine cell subtypes.

241 enterocytes, goblet cells, Paneth cells, and enteroendocrine cells, suggesting that the fusion partne

242 tively enriched in neuropod cells, a type of enteroendocrine cell that synapses with submucosal neuro

243 on in the gut leads to increased activity of enteroendocrine cells that release the peptide CCHa1.

244 ntains a diffuse endocrine system comprising enteroendocrine cells that secrete peptides or biogenic

245 Enteroendocrine cells, the largest and most diverse popu

246 teins, initiate gut peptide release from the enteroendocrine cells through small intestinal sensing p

247 Enteroendocrine cells throughout the gut and pancreas se

248 cy caused by disruption of PCSK1, failure of enteroendocrine cells to produce functional hormones res

249 How fatty acids stimulate enteroendocrine cells to release cholecystokinin (CCK) i

250 that fatty acids can interact directly with enteroendocrine cells to stimulate CCK secretion via inc

251 e body, but remarkably little is known about enteroendocrine cell type specification in the embryo an

252 antral stomach and intestine, whereas other enteroendocrine cell types exhibited much lower cell cyc

253 developing endoderm results in a decrease of enteroendocrine cell types including gastrin-, glucagon/

254 efining the physiological roles of different enteroendocrine cell types provides an essential framewo

255 continued in a significant fraction of most enteroendocrine cell types throughout fetal and postnata

256 Chemogenetic activation of different enteroendocrine cell types variably impacted feeding beh

257 Other enteroendocrine cell types were not ablated.

258 g embryonic development Nkx2.2 regulates all enteroendocrine cell types, except gastrin and preproglu

259 en-responsive paracrine pathway in which two enteroendocrine cell types, peptide YY (PYY)-expressing

260 However, individual enteroendocrine cells typically produce multiple, someti

261 the taste G protein gustducin, expressed in enteroendocrine cells, underlie intestinal sugar sensing

262 cids directly influence peptide release from enteroendocrine cells using STC-1, a mouse intestinal en

263 tic of enterocytes, and a loss of goblet and enteroendocrine cells was observed.

264 ation, and altered proportions of goblet and enteroendocrine cells) was inhibited by AG1024.

265 chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 6

266 ucagon-like peptide 1 and 2 secreting L-type enteroendocrine cells were decreased, whereas stem and g

267 In keeping with this, no enteroendocrine cells were detected in intestinal biopsy

268 ght junctions and desmosomes, and goblet and enteroendocrine cells were present.

269 enterocytes, goblet cells, Paneth cells, and enteroendocrine cells were stable over time.

270 ction and transduction are also expressed in enteroendocrine cells where they underlie the chemosenso

271 T2Rs are also expressed in gut-derived enteroendocrine cells, where they have also been hypothe

272 labsorptive diarrhea due to complete loss of enteroendocrine cells, whereas endocrine pancreas develo

273 Enteroendocrine cells, which are relatively rare in the

274 ese hormones and microbes act on gut sensory enteroendocrine cells, which modulate downstream activit

275 mechanical stimulation to activate TrpA1 in enteroendocrine cells, which, in turn, regulates intesti

276 reconstituted in vitro by coculturing single enteroendocrine cells with sensory neurons.

277 -HIO, which can be induced to be enriched in enteroendocrine cells, with L. reuteri 6475 or 17938 con

278 iated lineages, particularly enterocytes and enteroendocrine cells, yet display the worst prognosis i