ライフサイエンスコーパス: enzyme

1 re not observed in the KPC-2:cefotaxime acyl-enzyme.

2 moter recognition sigma factor from the core enzyme.

3 ant isocitrate dehydrogenase 1 (IDH1; mIDH1) enzyme.

4 local viral delivery of the Cre-recombinase enzyme.

5 nd enable additional hydrogen bonds with the enzyme.

6 hways in the Kok effect, including the malic enzyme.

7 ovel compounds that selectively inhibit this enzyme.

8 slation, yielding a truncated, nonfunctional enzyme.

9 tive T. gondii CGL gene encodes a functional enzyme.

10 y toxicity target and a major detoxification enzyme.

11 es for a putative superoxide reductase (SOR) enzyme.

12 focus on scalable chemical production using enzymes.

13 by direct optimization using single purified enzymes.

14 ing structural features of integral membrane enzymes.

15 isolation of responsible microorganisms and enzymes.

16 sting evolutionary conservation in different enzymes.

17 tool and compare it to other peptide ligase enzymes.

18 n the hydrolysis reaction catalyzed by these enzymes.

19 acy of organometallic species in radical SAM enzymes.

20 anisms controlling the diverse roles of SMYD enzymes.

21 biotic resistance mediated by beta-lactamase enzymes.

22 steps, introduction of mutations, or use of enzymes.

23 r synthesizing abiotic polymer inhibitors of enzymes.

24 utyrylcholinesterase, urease, and tyrosinase enzymes.

25 Here we report that the inositol-requiring enzyme 1 (IRE1alpha) branch of the UPR is directly invol

26 beta-site amyloid precursor protein cleaving enzyme 1, and both total and hyperphosphorylated tau exp

27 ite amyloid precursor protein (APP) cleaving enzyme-1 (BACE-1), and Abeta42 and tau aggregation inhib

28 differences in their angiotensin-converting enzyme 2 (ACE2) receptors.

29 iral spike protein to angiotensin-converting enzyme 2.

30 Here, we have examined a critical enzyme, 3-deoxy-d-arabino-heptulosonate 7-phosphate synt

31 ion monitoring (sPRM) was used to detect the enzyme, 5-enolpyruvulshikimate-3-phosphate synthase, fro

32 t on the characterization of acyl-activating enzymes (AAEs) that catalyze the formation of CoA esters

33 Here, McClafferty et al. identify two enzymes, ABHD17a and ABHD17c, that excise BK channel lip

34 Consistently, mitochondrial ETC enzyme activities and membrane potential were lowered in

35 g the identification of novel substrates and enzyme activities towards the synthesis of monolignols.

36 he effects of single amino acid variation on enzyme activity and steady-state cellular abundance with

37 ere validated by mitochondrial respirometry, enzyme activity assays and gene expression analyses.

38 otype in normal rat strains, increased NDEL1 enzyme activity in blood.

39 he LPL-GPIHBP1 fusion protein exhibited high enzyme activity in in vitro assays.

40 6 and by GR siRNA transfection and that DPP4 enzyme activity is reduced by DPP4 inhibitors.

41 Selection for a promiscuous enzyme activity provides substantial opportunity for com

42 and a study of their ability to modulate PPO enzyme activity.

43 s have been classically developed to inhibit enzyme activity; however, new classes of small molecules

44 Heat treatment without enzyme addition also significantly affected the composit

45 Enzyme addition improved the emulsion physical stability

46 otidyl transferases, formation of a covalent enzyme-adenylate intermediate is a common first step of

47 r formation as it is a crucial state of this enzyme, allowing for a rapid response demanded by the bi

48 Some of these enzymes also modulate the effect that biochemical noise

49 osate containing samples causes formation of enzyme-analyte complexes and a competitive loss of avail

50 in the KPC-4 than the KPC-2 ceftazidime acyl-enzyme and are not observed in the KPC-2:cefotaxime acyl

51 al changes that the Michaelis complex of the enzyme and natural substrate undergoes which align the n

52 with this assay, including the importance of enzyme and substrate concentrations, covariation of magn

53 FA-mediated regulation of BCAA-catabolizing enzymes and BCKA content and highlights the biological r

54 eethylase (EROD) activity of cytochrome P450 enzymes and continuous accumulation of fluoxetine and 11

55 3, which was highly susceptible to digestive enzymes and did not alter zebrafish embryos' morphology

56 he study of electron transfer in other redox enzymes and paves the way to explore transient states in

57 obes and formulated a master mix composed of enzymes and proteins produced in-house.

58 mbination of a pipette tip, wire electrodes, enzyme, and cotton wool filter, allows the fabrication o

59 res present: B. subtilis gyrase is a minimal enzyme, and its subunits can functionally interact with

60 ation, inactivation of lysosomal degradation enzymes, and disruption of antigen presentation pathways

61 mologous to mammalian carboxylesterase (CES) enzymes, and show that a number of these enzymes are res

62 the mutant isocitrate dehydrogenase 1 (IDH1) enzyme, approved for treatment of IDH1-mutant (mIDH1) ac

63 A plant-origin deconjugase enzyme (Arabidopsis thaliana) for deconjugation of folat

64 of lipid biosynthetic enzymes, but how these enzymes are assembled into metabolons and which substrat

65 Enzymes are central components of most physiological pro

66 s with translocases and other DNA-processing enzymes are far more extensive and impressive than was t

67 Histone-modifying enzymes are implicated in the control of diverse DNA-tem

68 However, the leading Cas9 and Cas12a enzymes are limited in their ability to make large delet

69 ES) enzymes, and show that a number of these enzymes are responsible for the selective addition of sp

70 resolved this paradox by showing that these enzymes are strong promoters of microtubule growth.

71 e low expression of the arginine resynthesis enzymes argininosuccinate synthase (ASS) and ornithine t

72 cers, and there is growing interest in zDHHC enzymes as novel drug targets.

73 GII may represent an ancestral form of these enzymes, as its activity is independent of the nucleic a

74 egions of brain, we have developed on-tissue enzyme-assisted derivatization in combination with micro

75 probes are often designed to target specific enzymes associated with diseases by direct optimization

76 tein) synthases, peroxisomal acyl-activating enzymes, ATP binding cassette (ABC) transporters, and ce

77 termined, delineating the divergence between enzymes based on organism, substrate, and mechanism.

78 predicted from the genomic islands coded for enzymes belonging to the Nitro-FMN-reductase superfamily

79 he GBA gene, which encodes for the lysosomal enzyme beta-glucocerebrosidase (GCase), resulting in the

80 or protein, its pro-amyloidogenic processing enzyme beta-site amyloid precursor protein cleaving enzy

81 lve the overexpression of lipid biosynthetic enzymes, but how these enzymes are assembled into metabo

82 ysteines via bilin lyases, and some of these enzymes, called lyase isomerases, attach phycoerythrobil

83 In eukaryotes, the DXO/Rai1 enzymes can eliminate most of the incomplete and non-can

84 Endonuclease V (eEndoV), an inosine-cleaving enzyme, can be repurposed to bind and isolate A-to-I edi

85 The model also includes the activity of the enzyme Carbonic Anhydrase 9 (CA9), a known marker of tum

86 losides, through the use of highly selective enzyme cascades.

87 lysis and points to the competing factors of enzyme catalysis and ET efficiency that may arise when c

88 nano-bio interfaces involved in light-driven enzyme catalysis and points to the competing factors of

89 imics the modes of activation and control in enzyme catalysis and the realization that this can be ac

90 pand the documented constellation of di-iron enzyme catalysis to include a dioxygenase reactivity in

91 These enzymes catalyze reactions that regulate epigenetic inhe

92 1,3-diene to a tetrasubstituted double bond, enzyme-catalyzed malonate desymmetrization, and highly d

93 the likelihood of detecting plausible novel enzyme-chemical relationships.

94 This enzyme cleaved the tripeptide aldehyde protease inhibito

95 The ATP citrate lyase (ACLY) enzyme cleaves cytosolic citrate to generate acetyl-CoA,

96 r-adjacent motifs (PAM); is a multi-turnover enzyme; cleaves ssDNA, dsDNA and RNA targets in a single

97 ng digestion, warm enzymatic digestion using enzyme collagenase:NP activity ratio < 10:1, coupled wit

98 structure that is cleaved at its base by an enzyme complex known as the Microprocessor (Drosha/DGCR8

99 Antibody-enzyme complexes (AECs) with binding ability to specific

100 ed by MenD, a thiamine diphosphate-dependent enzyme comprising three domains.

101 This enzyme consists of four catalytic subunits: biotin carbo

102 ATP-dependent chromatin-remodeling enzymes control accessibility, nucleosome positioning/oc

103 Resting and activated sGC enzyme converts guanosine triphosphate to an important s

104 our understanding of how bacterial cell wall enzymes cooperate to build a mature cell wall.

105 Results indicated that applied enzymes could hydrolyse polymeric arabinoxylan while the

106 ed cell types (mosaic data) or from purified enzyme data.

107 Exposure of the enzyme decorated biochip to glyphosate containing sample

108 essive condition known as Glycogen Branching Enzyme Deficiency (GBED) is the result of one of these d

109 Enzymes dependent on nicotinamide cofactors are importan

110 However, the second enzyme (designated CsGA1ox/ds) performed multiple reacti

111 are sequentially processed by two RNase III enzymes, Drosha and Dicer.

112 yed a drug release pattern in response to pH/enzyme dual stimuli and was enzymatically biodegradable.

113 We identified Ube2v1 (ubiquitin-conjugating enzyme E2 variant 1) in a genome-wide screen designed to

114 une-based mechanism for the observed hepatic enzyme elevations.

115 t direct electron transfer of oxidoreductase enzymes enabled by single walled carbon nanotubes and co

116 Human tyrosinase (hsTYR) is the key enzyme ensuring the conversion of l-tyrosine to dopaquin

117 ate inhibitors of norovirus 3CL protease, an enzyme essential for viral replication.

118 d explain how a family of cGAS-STING evasion enzymes evolved from viral proteases through gain of sec

119 estriction or with bacterial l-Met-degrading enzymes exerts potent antitumor effects.

120 In contrast, the MA involved tri-enzyme extraction including human plasma as a deconjugas

121 rmacological targeting of DUBs establish the enzyme family as targetable and provide a framework for

122 to PG, catalyzed by the LytR-CpsA-Psr (LCP) enzyme family, offers a unique extracellular target for

123 Most of the enzyme filaments known to date have only been observed i

124 umber of neurons expressing the biosynthetic enzyme for serotonin, tryptophan-hydroxylase-2 (TPH2), i

125 ck an economical and highly stable chitinase enzyme for use in the industrial sector.

126 enes (tktAB) suggests the importance of this enzyme for xylose metabolism.

127 However, utilisation of NADH-dependent enzymes for (2)H-labelling is not straightforward, owing

128 iated factor 1 (CAF1) proteins are important enzymes for catalysis of mRNA deadenylation in eukaryote

129 so be applied to the immobilization of other enzymes for industrial biocatalysis.

130 osphatidylcholine or cholesterol but encodes enzymes for phosphatidylethanolamine (PE) biosynthesis;

131 fied TmAAE1 and TmAAE5 as the most efficient enzymes for the activation of butyric acid (Taxol D side

132 he latter process is mediated by PG cleavage enzymes, for example, the endopeptidases (EPs).

133 atforms for efforts to harness principles of enzyme function for catalyst design.

134 ytic on-protein radical generation; to study enzyme function with natural, unnatural and CF(2)-labell

135 es in either ring to be active for efficient enzyme function.

136 substrate profile of AldC suggests that this enzyme functions as a long-chain aliphatic aldehyde dehy

137 GAD1 encodes the glutamate decarboxylase enzyme GAD67, a critical actor of the gamma-aminobutyric

138 We found that by using photoexcitation these enzymes gain the ability to reduce acrylamides through a

139 be enriched for the glucose phosphorylating enzyme glucokinase and for genes encoding other enzymes

140 or eicosapentaenoic acid (EPA), and (2) the enzyme group, including cyclooxygenase (COX), lipoxygena

141 In secondarily thickened hypocotyls, these enzymes had positive effects on vessel element expansion

142 This enzyme has also emerged as a therapeutic target for card

143 epoxides generated by cytochrome P450 (CYP) enzymes have been linked to increased tumor growth and m

144 spects of the catalytic mechanism of the Msr enzymes have been reported, several details still await

145 So far, several enzymes have been shown to be rapidly degraded through t

146 Yet the identity of detyrosinating enzymes have remained ambiguous, hindering mechanistic s

147 Rebaudioside A significantly improved liver enzymes, hepatic steatosis and hepatic fibrosis.

148 of RNF213 uncovers a distinct type of an E3 enzyme, highlighting the growing mechanistic diversity i

149 another (p)ppGpp target, the purine salvage enzyme HPRT, suggesting evolutionary conservation in dif

150 tivity of the C-terminal domain of bacterial Enzyme I (EIC).

151 the OsSBEIIb gene encoding starch branching enzyme IIb, which is required for amylopectin synthesis

152 rated a completely non-uniform surface after enzyme immobilization on the glass bead, which seemed to

153 scharge were tested in viral neutralization, enzyme immunoassay (EIA), and Western immunoblot tests a

154 MBL, and antibody serology were analyzed by enzyme-immunoassays; viral load by PCR.

155 deficient for ELOVL2 (Elovl2(-/-) ), the key enzyme in DHA synthesis.

156 se (NAMPT), an essential NAD(+) biosynthetic enzyme in skeletal muscle, decreased by 14% with NR.

157 MINOTRANSFERASE OF ARABIDOPSIS (TAA1), a key enzyme in the auxin biosynthesis pathway in Arabidopsis

158 ed with tyrosine hydroxylase, a biosynthetic enzyme in the dopamine pathway.

159 anslation initiation factor 2B, an essential enzyme in the initiation of protein synthesis, into larg

160 IspH, an enzyme in the methyl erythritol phosphate pathway of iso

161 ide:quinone oxidoreductase (SQOR), the first enzyme in the sulfide oxidation pathway.

162 Many different enzymes in intermediate metabolism dynamically assemble

163 ence that supports a pathogenic role for PAD enzymes in RA as both promoters and targets of the autoi

164 The physiological activity of pancreatic enzymes in the ileum has been studied in healthy volunte

165 Enzymes including papain, alpha-amylase, glucose oxidase

166 entry point Cu(A) is also utilized in other enzymes, including cytochrome c oxidase.

167 chain [NFL]), inflammatory, and antioxidant (enzymes, including heme oxygenase isoforms [HO-1, HO-2])

168 have shed light on various aspects of these enzymes, including their structure, mechanism, alternati

169 same year, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers.

170 use of systemically administered epigenetic enzyme inhibitors for relapse prevention in human drug u

171 not support stopping angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in pa

172 As the first example of the enzyme-instructed self-assembly of a synthetic peptide f

173 The acyl-enzyme intermediate is a central milestone in the hydrol

174 of new nanomaterials to incorporate desired enzymes into the protein shell for enhanced catalytic pe

175 P-ribose) polymerase 1 (PARP-1) is a nuclear enzyme involved in DNA repair and transcription regulati

176 TKFC encodes a bifunctional enzyme involved in fructose metabolism through its glyce

177 cs and gene expression analysis, we identify enzymes involved in carbohydrate metabolism as transcrip

178 yme glucokinase and for genes encoding other enzymes involved in glucose metabolism compared to follo

179 9 homolog 2 (SUV39H2), key histone-modifying enzymes involved in promoting reduced chromatin accessib

180 metalloproteinases (MMPs) are extracellular enzymes involved in the degradation of extracellular mat

181 onical radical S-adenosyl-l-methionine (SAM) enzymes involves electron transfer (ET) from [4Fe-4S](+)

182 The inositol-requiring enzyme (IRE1) is one ER stress sensor that is activated

183 This enzyme is responsible for elimination of unconjugated bi

184 Coordinating multiple activities of complex enzymes is critical for life, including transcribing, re

185 The activity of many enzymes is regulated by associative processes.

186 superfamily of hepatic cytochrome P450 (CYP) enzymes is responsible for the intrinsic clearance of th

187 In the design of high-affinity and enzyme isoform-selective inhibitors, we applied an appro

188 an discriminate between structurally related enzyme isoforms.

189 nserved microtubule (MT)-severing AAA-ATPase enzyme Katanin is emerging as a critical regulator of MT

190 Here, we review previously reported enzyme kinetic parameters of cellular and viral DNA and

191 U-loop residues reveals its contribution to enzyme kinetics and thermostability.

192 Genetic complementation studies and enzyme kinetics assays indicate that B. fragilis UroS is

193 Enzyme kinetics indicated that this RdRp efficiently inc

194 monomers and thereby counteracts MICAL1, an enzyme known to depolymerize actin filaments by direct o

195 on substitutions encoding a single essential enzyme lead to dramatically slower cell growth.

196 Extracellular enzymes, lignin degradation and cell growth are crucial

197 We evaluated these antigens by enzyme-linked immunosorbent assay (ELISA) using sera fro

198 Here, we developed a simple enzyme-linked immunosorbent assay (ELISA)-based assay th

199 mage, neurofilament light chain (NfL), using enzyme-linked immunosorbent assay and electrochemilumine

200 mated in peri-implant crevicular fluid using enzyme-linked immunosorbent assay method and assessed wi

201 We used an enzyme-linked immunosorbent assay to measure levels of s

202 ction antibody titer (measured by inhibition enzyme-linked immunosorbent assay) and dengue severity,

203 The PC- and gB-specific ABs were assessed by enzyme-linked immunosorbent assay.

204 ry, real-time polymerase chain reaction, and enzyme-linked immunosorbent assay.

205 cessory subunit (CoREST) enables a chromatin enzyme (LSD1) to function on a nucleosome and not just h

206 y challenging reactions catalyzed by complex enzyme machineries with unique metal-containing cofactor

207 s-of-function mutations in histone-modifying enzymes may cause severe neurodevelopmental disorders.

208 of drug discovery efforts targeting selected enzymes (MbtI, MbtA, MbtM, and PPTase) from the mbt gene

209 ymes that attach lipid groups are known, the enzymes mediating lipid removal (i.e. deacylation) are l

210 report the first evidence that a radical SAM enzyme MoaA accelerates the radical-mediated C-C bond fo

211 odified and organophosphorus hydrolase (OPH) enzyme-modified carbon paste (CP) microneedle electrodes

212 e therapeutic potential of isoform-selective enzyme modulation are lacking.

213 r capacity as NAD(+) is a substrate for PARP-enzymes (mono/poly-ADP-ribosylation) and sirtuins (deace

214 The enzyme N-myristoyltransferase (NMT) is an essential prot

215 nd high transduction activity towards the co-enzyme NADH, delivering a wide linear range of 20-960 mu

216 Secreted enzymes, namely laccases (LACs) and peroxidases (PRXs),

217 ort, we describe the utility of one of these enzymes, Nepenthesin II (NepII), in a HDX-MS workflow.

218 structures T(1)L(1) and T(2)L(2) and nicking enzyme Nt.BbvCI, undergoes dissipative orthogonal transi

219 oyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is re

220 cific chaperone that stabilizes the effector enzyme of phototransduction, cGMP phosphodiesterase 6 (P

221 Triosephosphate isomerase (TIM), an enzyme of the glycolytic pathway, has emerged as a usefu

222 idase 1) encodes the first and rate-limiting enzyme of the very-long-chain fatty acid (VLCFA) beta-ox

223 tivity site that can allosterically turn the enzyme on or off by the binding of ATP or dATP, respecti

224 ently immobilizing the glucose oxidase (GOD) enzyme onto an ultramicro electrode (UME) to measure the

225 rapid and thermodynamically favorable after enzyme opening and pyrophosphate release, and it appears

226 rly outperformed conventional labels such as enzymes or fluorescent dyes.

227 ipid A by the outer membrane acyltransferase enzyme PagP occurs in immunostimulatory Ypt and Ye strai

228 Unable to generate new enzyme paradigms and metabolic networks de novo, organis

229 mation, cellular infiltration, tissue repair enzymes, pathways of oxidative stress, and altered intes

230 The HIF prolyl hydroxylase domain enzymes (PHDs) are Fe(II)- and 2-oxoglutarate-dependent

231 The enzyme phenylethanolamine N-methyltransferase (PNMT, EC

232 s were dependent on the glucose-metabolizing enzyme phosphogluconate dehydrogenase (PGD).

233 emonstrates how the widespread phenomenon of enzyme polymerization can be adapted to achieve differen

234 Fungal biomass, richness, and oxidative enzyme potential were reduced by N deposition where ambi

235 d source and the predicted categories of the enzymes present in the gut microbiomes of each species.

236 ng a core palette of triterpene-diversifying enzymes, presumably in response to strong environmental

237 t and enables intracellular deubiquitinating enzyme profiling.

238 ional genomics to identify a missing pathway enzyme, protein engineering to enable the functional exp

239 ubstantially broadens the versatility of the enzyme, providing a new approach to facilitate novel app

240 at lignin peroxidase (LiP), an extracellular enzyme purified from Phanerochaete chrysosporium NK-1 is

241 n oilseeds and suggest that phospholipase A2 enzymes rather than LPCAT mediate the highly efficient r

242 nd ET efficiency that may arise when complex enzyme reactions are driven by artificial light absorber

243 Moreover, the immobilized enzyme recovered by low g-force centrifugation retained

244 Secreted phospholipase A(2) (sPLA(2)) enzymes release free fatty acids, including arachidonic

245 es upstream of the yeast histone methylation enzymes remain unknown, we model the possible connection

246 wall integrity, the hexosamine biosynthesis enzymes represent potential targets of antifungal drugs.

247 Hydroxyprostaglandin dehydrogenase, an enzyme required for 15-Oxo-ETE synthesis, was predominan

248 ized that heme oxygenase 1 (HMOX1; HO-1), an enzyme responsible for degradation of heme to carbon mon

249 olipase D (NAPE-PLD) is regarded as the main enzyme responsible for the biosynthesis of N-acylethanol

250 glycosylase (OGG1) is a base excision repair enzyme responsible for the recognition and removal of 8-

251 Although genes encoding enzymes responsible for most steps of the ABA biosynthes

252 Here, we report the enzymes responsible for peptidoglycan N-deacetylation an

253 Many of the enzymes responsible for regulating protein and DNA modif

254 charide monooxygenases (LPMOs) are microbial enzymes secreted by fungal saprotrophs involved in carbo

255 Class I adenylate-forming enzymes share a conserved structural fold but act on a w

256 In vitro assays with human enzymes show that PCNA and its loader RFC are sufficient

257 The sensor with a fusion enzyme showed DET to a gold electrode, with a limited op

258 ium, siroheme is produced by a trifunctional enzyme, siroheme synthase (CysG).

259 Enzymes specialised for this task are known as ring nucl

260 This work demonstrates the value of enzyme stabilization through computational library desig

261 require dedicated structural features in the enzyme, such as a nucleotide hydrolysis site or multiple

262 d a plateau at the level of the best natural enzymes, suggesting that we have exhausted the potential

263 Recently, DNA-modifying enzymes (Taq DNA polymerase, Phi29 DNA polymerase) have

264 ur observations provide new insights into A3 enzyme target site selection and how A3 mutagenesis impa

265 Ten-eleven translocation (TET) family enzymes (TET1, TET2, and TET3) oxidize 5-methylcytosine

266 (NAT1) is a phase II xenobiotic-metabolizing enzyme that also has a role in cancer cell growth and me

267 Nocturnin (NOCT) is a eukaryotic enzyme that belongs to a superfamily of exoribonucleases

268 persisted for millions of years without the enzyme that can efficiently add methyl groups de novo.

269 cess of poly(ADP-ribosyl)ation and the major enzyme that catalyses this reaction, poly(ADP-ribose) po

270 Nitrogenase is the enzyme that catalyzes biological N(2) reduction to NH(3)

271 Whereas the enzymes that attach lipid groups are known, the enzymes

272 Kinases are the enzymes that catalyze the phosphorylation of other prote

273 acquired multidrug resistance loci, encoding enzymes that confer resistance to nonrelated antibiotics

274 ly ancient protein domain present in several enzymes that hydrolyze cyclic phosphate bonds on differe

275 t uses DNA polymerases, nucleases, and other enzymes that modify incompatible DNA ends to allow their

276 nduction of cholesterol biosynthetic pathway enzymes that produce retinoid-related orphan receptor (R

277 (OASs) are a family of interferon-inducible enzymes that require double-stranded RNA (dsRNA) as a co

278 Aldehyde dehydrogenases are versatile enzymes that serve a range of biochemical functions.

279 11-C10, yielded a lineage of engineered P411 enzymes that together accommodate a variety of internal

280 The DHHC enzyme then becomes autoacylated at a site defined by a

281 ndelibly shaped the diversification of these enzymes through deep time.

282 on; this increases the ratio of ATP synthase enzyme to its c-subunit, enhancing ATP production effici

283 fluorescence protein, EYFP) with the target enzymes to calibrate the chemometric model.

284 perature dependence of biotic processes from enzymes to evolution; the wavelength dependence of the e

285 of seven microorganisms encoding active ArsM enzymes to methylate As.

286 sine phosphorylase (MTAP), the rate-limiting enzyme, to relieve strain.

287 (tRNAs), tRNA synthetases, tRNA-modification enzymes, translation-initiation and elongation factors,

288 m the typical sugar metabolism by only three enzymes, turning a non-methylotrophic organism to a synt

289 bed the structure and mechanism of these two enzymes using crystallographic, spectroscopic and fast k

290 gn parameters such as the surface density of enzymes, various reaction constants as well as electrica

291 small molecules that endow new functions to enzymes via proximity-mediated effect are emerging.

292 We showed that the enzyme was active on Galalpha1-3Gal but not the blood gr

293 d negligible activity with SAC; however, the enzyme was highly active with l-cysteine, N-acetyl-l-cys

294 th minimal invasiveness, the synergy of both enzymes was very useful to increase the number of annota

295 bor a full complement of cobalamin metabolic enzymes, we used genome editing to study the loss of mma

296 that, in contrast to other alphaKG-dependent enzymes (which are six coordinate when only alphaKG is b

297 Here, we identify a family of over 30 enzymes, which are homologous to mammalian carboxylester

298 oproteases as regulatory and quality control enzymes will help unravel the role of mitochondrial plas

299 36 methyltransferase in yeast, by fusing the enzyme with the light-activated nuclear shuttle (LANS) d

300 2AA accumulation inhibits target enzymes with a detrimental impact on fitness.