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1 romote eNOS denitrosylation concomitant with enzyme activation.
2 scussed with respect to the implications for enzyme activation.
3 nd reveal that Glu493 is critical for low pH enzyme activation.
4 T followed by its GSH-mediated reduction and enzyme activation.
5 r-783 phosphorylation was not sufficient for enzyme activation.
6 proposed to be necessary and sufficient for enzyme activation.
7 calcineurin, whereas U-73343 failed to block enzyme activation.
8 omain amino acids are responsible for low-pH enzyme activation.
9 ent of Pgamma from the PDE6 active site, and enzyme activation.
10 nformational dynamics that may be related to enzyme activation.
11 ulting in a 50-60% reduction in the level of enzyme activation.
12 hox)) that undergo structural changes during enzyme activation.
13 NOS dephosphorylation at serine 116 leads to enzyme activation.
14 hereby facilitating eNOS phosphorylation and enzyme activation.
15 nterdomain interactions that are critical to enzyme activation.
16 l outside the protease domain also influence enzyme activation.
17 ch stabilizes a disordered loop and leads to enzyme activation.
18 sabled by Ser(1179) phosphorylation-elicited enzyme activation.
19 )-) resulting in propeptide dissociation and enzyme activation.
20 el incorporation matched the time course for enzyme activation.
21 -induced structural changes in PLA2, and the enzyme activation.
22 amino half of calcineurin-B is critical for enzyme activation.
23 GSTP1-1-JNK interaction and concomitant JNK enzyme activation.
24 -Ca-ATPase that are normally associated with enzyme activation.
25 liver Ni(II) to the urease apoprotein during enzyme activation.
26 protein kinase C-mediated, and extracellular enzyme activation.
27 eractions with the PM Ca-ATPase that induces enzyme activation.
28 important to high-affinity binding and rapid enzyme activation.
29 n of the amino-terminal domain necessary for enzyme activation.
30 ic state of GPI-PLC during latency and after enzyme activation.
31 ylglycerol binding, which eventually lead to enzyme activation.
32 her than impairment of (13S)-HPODE-dependent enzyme activation.
33 te on the PM-Ca-ATPase are not necessary for enzyme activation.
34 and/or for the subsequent steps that lead to enzyme activation.
35 uired for both the conformational change and enzyme activation.
36 nity for substrate and consequently leads to enzyme activation.
37 andem C1a and C1b domains in PKC, leading to enzyme activation.
38 Kd (0.1 microM) corresponds to the EC50 for enzyme activation.
39 Galphaq, is suggested as a mechanism for the enzyme activation.
40 eavage is necessary, but not sufficient, for enzyme activation.
41 nding of Ca2+-calmodulin to eNOS, leading to enzyme activation.
42 effect of PAF on PLA2-II gene expression and enzyme activation.
43 oteins, which, in normal controls, parallels enzyme activation.
44 Swiss 3T3 cells, palytoxin causes prolonged enzyme activation.
45 to play a role in membrane translocation and enzyme activation.
46 n; and (4) mTOR-membrane engagement and full enzyme activation.
47 al light-absorbing rhodopsin responsible for enzyme activation.
48 ctivation, with a K(D) of 29 muM and 387% of enzyme activation.
49 dynamics of USP7 in solution and its role in enzyme activation.
50 gnition as a putative mechanism of cGAS-like enzyme activation.
51 -protein interaction specificity that alters enzyme activation.
52 reveals key details of the mechanism of TIR enzyme activation.
53 utilize substrate dianion binding energy for enzyme activation.
54 , thereby imposing a novel checkpoint during enzyme activation.
55 x that leads to acidification and hydrolytic enzyme activation.
56 x into the heterodimer interface, leading to enzyme activation.
57 effector binding plays an additional role in enzyme activation.
58 e dimer-to-tetramer transition necessary for enzyme activation.
59 poglycemia reveal two distinct mechanisms of enzyme activation.
60 jor regulating element for self-assembly and enzyme activation.
61 ion site for Nox1-NOXA1 binding required for enzyme activation.
62 ant cellular processes such as signaling and enzyme activation.
63 of class C sortase substrate recognition and enzyme activation.
64 clases have a common molecular mechanism for enzyme activation.
65 where it can lead to intracellular digestive enzyme activation.
66 cular insight into the mechanism of PKCalpha enzyme activation.
67 (2+) dependencies for calmodulin binding and enzyme activation.
68 at oxidation disrupts calmodulin binding and enzyme activation.
69 more compact structure that is required for enzyme activation.
70 o differentiate between specific and general enzyme activation.
71 eneration of superoxide anion (O(2)(*)) upon enzyme activation.
72 tion is coupled to phosphorylation-dependent enzyme activation.
73 rdomain contacts important for DNA-dependent enzyme activation.
74 ut significant effect on the Zn2+ K(1/2) for enzyme activation.
75 ion of PLCgamma1 Y783, which is critical for enzyme activation.
76 ardiolipin (CL) is the best phospholipid for enzyme activation.
78 specific residues involved in PIP2-mediated enzyme activation, amino acids with functional side chai
79 he close correspondence between caspase-like enzyme activation and an associated increase in immunore
80 functions as a regulator of membrane binding/enzyme activation and as an inhibitor of catalysis in th
81 ues involved in Tyr(P) binding abrogated the enzyme activation and association of PKCtheta with Tyr-p
82 e H activity where one metal is required for enzyme activation and binding of a second metal is inhib
83 sduction is controlled both by regulation of enzyme activation and by organization of enzymatic compl
89 eptide and protein/protein interactions, and enzyme activation and inactivation, in response to Ca2+
91 of caspase 1 processing, thereby inhibiting enzyme activation and maturation of IL1beta/18 in a LUBA
95 subtype localization and its relationship to enzyme activation and target phosphorylation have not, h
96 discuss the recent uses of ionic liquids in enzyme activation and their combination with nanosized m
97 genin is very low, and the mechanisms of the enzyme activation and tRNA specificity have remained a p
99 sors that can measure analyte concentration, enzyme activation, and protein-protein interactions in l
100 IP(3)-3KB structure suggests a mechanism of enzyme activation, and raises the possibility that an in
101 , which enhance catechin production, terpene enzyme activation, and stress tolerance, important featu
102 rcolemmal receptor activation, intracellular enzyme activation, and ultimately mitochondrial stabilis
103 RAPTOR-membrane engagement and intermediate enzyme activation; and (4) mTOR-membrane engagement and
104 ing the affinity for substrates, whereas the enzyme activation appeared to be specifically controlled
105 ed with using only trypsin and CID, the dual-enzyme/activation approach enabled the identification of
106 man SIRT2), only SIRT1 exhibited significant enzyme activation ( approximately 8-fold) using the comm
107 in the protein tryptophan fluorescence) and enzyme activation are both cooperative with Hill coeffic
109 mma1 phosphorylation to dramatically enhance enzyme activation as observed, we found that high intram
110 gainst SOD1 misfolding does not require SOD1 enzyme activation as the same effect was obtained with t
111 or of Gbetagamma attenuated S1P-induced eNOS enzyme activation, as well as S1P-induced phosphorylatio
114 rylation of Nox5 at key residues facilitates enzyme activation at lower levels of intracellular calci
115 the differential requirement of Ca2+/CaM for enzyme activation between eNOS and iNOS by either deleti
116 spase-3 by 24 hours and a clear induction of enzyme activation by 48 hours, which was identified by t
120 and Asp(818) to Asn interferes strongly with enzyme activation by Ca(2+) binding and formation of pho
123 thelial plasma membranes, and Ptox prevented enzyme activation by E(2) in COS-7 cells expressing ERal
125 scoclaurine alkaloid known to inhibit PLA(2) enzyme activation by heterotrimeric G-proteins, effectiv
126 c ion, as well as a prodomain that regulates enzyme activation by modulation of a cysteine residue wi
128 rich repertoire of molecular mechanisms for enzyme activation by Na(+) and K(+) Strategies range fro
129 alytic residues, and determine the origin of enzyme activation by the hydrophobic leaving group.
130 W indicates that Ca(2+)/CaM binding promotes enzyme activation by transferring F293 from an internal
131 ulated active conformations, indicating that enzyme activation can occur spontaneously, even in the a
132 ear channel binding affinity and potency for enzyme activation, confirming the mechanism of allosteri
133 D brain, it is hypothesized that the lack of enzyme activation contributes to the accumulation of ins
135 that the role of tyrosine phosphorylation in enzyme activation differs between vertebrates and invert
139 s polyP may differentially modulate specific enzyme activation events within the contact pathway.
140 nase that requires charged phospholipids for enzyme activation, for regulation by Gbetagamma subunits
141 0)(Ca(2+)) values for calmodulin binding and enzyme activation from the control values of 182 +/- 2 a
142 0(Ca (2+)) values for calmodulin binding and enzyme activation from the wild-type values of 180 +/- 2
143 egulated genes in the mouse uterus, and eNOS enzyme activation further indicated that EDC specificall
146 ation of the MgATP-binding pocket leading to enzyme activation has been demonstrated for ribokinases.
147 on of cytosolic NADPH oxidase components and enzyme activation has been identified but is not well un
148 novel models to study the role of pathologic enzyme activation has led to advances in our understandi
149 r Ca(2+) homeostasis and premature digestive enzyme activation; however, the molecular mechanisms by
150 llular calcium and may provide an avenue for enzyme activation in response to a greater variety of ex
151 or CCS in the SOD1 pathway, namely mediating enzyme activation in response to increases in oxygen ten
153 d for at least 30min and was able to trigger enzyme activation in vitro at heparin level of 0.4U/mL.
154 ubcellular distribution of PKC (a measure of enzyme activation) in a growth factor-dependent pluripot
155 the signature of somatic hypermutation (SHM) enzyme, Activation Induced Deaminase (AID), which overla
156 ction of DNA damage into the Ig genes by the enzyme activation-induced cytidine deaminase (AID) and t
160 ) is characterized by elevated levels of the enzyme activation-induced cytidine deaminase (AID), an e
161 n of the oncogenic LMP1 and the DNA-mutating enzyme activation-induced cytidine deaminase (AID), in t
162 ition, including one lacking the DNA-editing enzyme activation-induced cytidine deaminase (AID), whic
163 alongside mRNA for the transiently-expressed enzyme Activation-induced cytidine Deaminase (AID).
164 es of high affinity Abs are dependent on the enzyme activation-induced cytosine deaminase (AID).
165 ed immunoglobulin gene and expression of the enzyme activation-induced deaminase (AID) are essential
166 proliferating centroblasts that express the enzyme activation-induced deaminase (AID) to undergo som
167 is a critical immune process governed by the enzyme activation-induced deaminase (AID), a member of t
168 e created transgenic mice overexpressing the enzyme activation-induced deaminase (AID), which has a n
169 expression of FOXP1 and the B-cell mutagenic enzyme activation-induced deaminase, and immune evasion
170 pendent on the action of the B cell specific enzyme, activation-induced cytidine deaminase (AID), and
171 been difficult to uncouple because a single enzyme, activation-induced cytidine deaminase (encoded b
172 ressing B cells up-regulate the CSR-inducing enzyme, activation-induced cytidine deaminase, and under
173 linked with both processes dependent on the enzyme, activation-induced deaminase, and occurring prin
174 current view of the structural basis for CaM enzyme activation is based on biophysical studies of CaM
176 vior is consistent with the observation that enzyme activation is detected at low short-chain anionic
177 ivation of myo-inositol monophosphatase, and enzyme activation is enhanced under conditions in which
179 h an eNOS-caveolin regulatory cycle, wherein enzyme activation is modulated by reversible protein-pro
183 SH3 domains in promoting substrate binding, enzyme activation likely reorients the relative spatial
184 including the regulation of blood pressure, enzyme activation, maintenance of muscular strength, reg
185 high affinity and suggest that inhibition of enzyme activation may be an unrecognized mechanism of in
186 vity of PDE5 suggests that this mechanism of enzyme activation may be common among other GAF domain-c
189 i-associated furin is analogous to a similar enzyme activation mechanism observed with stromelysin-3.
190 ata from these structures in terms of target enzyme activation mechanisms is that the larger enzyme s
191 omeostasis, regulation of protein synthesis, enzyme activation, membrane potential adjustment and ele
194 th PAF and LPS induce gene transcription and enzyme activation of PLA2-II in the small intestine; 2)
199 bove antisense oligodeoxynucleotides inhibit enzyme activation, our results exemplify an unusual mode
200 +/ATPase activation occurred and binding and enzyme activation persisted long after the Ca transient
201 for affinity column binding, suggesting that enzyme activation precedes carbohydrate maturation and t
204 ism that relates calmodulin (CaM) binding to enzyme activation remains to be established within the c
205 click" method utilizing an alkyne-terminated enzyme activation reporter, aldehyde-based fixation, and
206 of the molecular mechanism for CaM-dependent enzyme activation requires additional structural informa
208 As is the case for all retroviral proteases, enzyme activation requires the formation of protease hom
213 in the K0.5 values for calcium dependence of enzyme activation (shifted from 1.1 microM to 9.1 microM
214 hen added to the enzyme as a peptide, causes enzyme activation similar to that with Gbetagamma subuni
216 nes thought to be associated with pathologic enzyme activation (such as serine protease inhibitor 1)
217 gely responsible for the decreased extent of enzyme activation, suggesting that this site is critical
218 sphodianion-driven conformational changes to enzyme activation suggests that this catalytic motif has
220 gements in three sites implicated earlier in enzyme activation-the VSD-PD linker, gating loop and R l
221 anding of pancreatic intracellular digestive enzyme activation; the pancreatic inflammatory response;
222 lack of SAMe by bypassing the deficiency in enzyme activation; this is done by providing the product
223 ng to AKAPs and consequent modulation of the enzyme activation threshold rather than on overall chang
224 new molecular mechanisms in proximity-driven enzyme activation, threshold behavior, signal amplificat
227 calmodulin binding and calmodulin-dependent enzyme activation to 65 +/- 4 and 118 +/- 4 nM, respecti
231 properties of the tissue and ligand for both enzyme activation via collision coupling and the generat
232 onents was required for enzyme activity, and enzyme activation was associated with membrane transloca
233 steines as evidenced by the observation that enzyme activation was attenuated by thiol-containing nuc
234 In adherent multicellular isolate cultures, enzyme activation was followed by precipitation of arago
236 phinyl-oxy-TEMPO, respectively, suggest that enzyme activation was only weakly affected by changes in
238 to the lipid bilayer-a usual requirement for enzyme activation-was determined by using a sucrose-load
239 ntify structural changes that correlate with enzyme activation, we have used frequency-domain phospho
240 To probe the molecular mechanism of the enzyme activation, we performed a detailed account of th
241 NO coordination state, NO dissociation, and enzyme activation were significantly affected by the pre
242 These results are consistent with a model of enzyme activation where phosphorylation of the MAP kinas
243 of grade, had the highest overall degree of enzyme activation, whereas oligodendrogliomas had the le
244 euronal calpain nitrosylation and results in enzyme activation, which, in turn, leads to tau phosphor
245 ensus HEXXH zinc-binding region required for enzyme activation, while their cysteine-rich domains app
246 new concept in combination therapy, that of enzyme activation with two compounds that hit the same b