ライフサイエンスコーパス: enzyme activity

1 y, a post-translational control mechanism of enzyme activity.

2 in XLP alleviate autoinhibition and increase enzyme activity.

3 in vitro by a range of methods that inhibit enzyme activity.

4 correlation between sCD73 protein levels and enzyme activity.

5 e it can provide information about the local enzyme activity.

6 enabling a tuning or reversible switching of enzyme activity.

7 rrelation with the temperature dependence of enzyme activity.

8 ty acid incorporation; (7) liver antioxidant enzyme activity.

9 lated E1alpha subunit of PDH, which inhibits enzyme activity.

10 a sets, while correlating it to decreases in enzyme activity.

11 up II plants had higher ProDH and lower P5CS enzyme activity.

12 ithin the filament and for the regulation of enzyme activity.

13 on, resulting in decreased CSD and total SOD enzyme activity.

14 ective trade-off between thermostability and enzyme activity.

15 f between- and within-species differences in enzyme activity.

16 s*11) in SOD1 that leads to total absence of enzyme activity.

17 tential role for the juxtamembrane region in enzyme activity.

18 O2 at the level of transcripts, proteins and enzyme activity.

19 x with the HSA binding capacity and retained enzyme activity.

20 spectroscopy and compared with the change in enzyme activity.

21 he model to the data for measuring the CYP1A enzyme activity.

22 within the rs4680 allele result in variable enzyme activity.

23 isorder caused by a deficit of neuraminidase enzyme activity.

24 and a study of their ability to modulate PPO enzyme activity.

25 activity, while amino acid modifiers reduced enzyme activity.

26 ion loop to explore the role of this loop in enzyme activity.

27 The mutations cause an increase in enzyme activity.

28 : IL-1beta, IL-6, IL-18, and chitotriosidase enzyme activity.

29 mer formation rather than inhibition of PI3K enzyme activity.

30 suring the balance between histone-modifying enzyme activities.

31 uding ~5 d required for the determination of enzyme activities.

32 d for analysis of a wide range of DNA repair enzyme activities.

33 d water quality parameters, or innate immune enzyme activities.

34 o multimodal populations with differentiated enzyme activities.

35 al fatty acid beta-oxidation plus additional enzyme activities.

36 l fractions of C and N but also impacted the enzyme activities.

37 h spatially organized and chemically coupled enzyme activities.

38 saprotrophic fungi directly influenced soil enzyme activities.

39 ed levels of lysosomal proteins and lysosome enzyme activities.

40 lectron microscopy (IEM), Western blots, and enzyme activities.

41 ecause of higher microbial abundance and exo-enzyme activities.

42 dase, and dipeptidyl peptidase III (DPP III) enzyme activities.

43 e were no marked changes in any of the serum enzymes activities.

44 creased the constitutive (lipid-independent) enzyme activity ~4-fold.

45 acturonase in buffer, with >90% reduction of enzyme activity after applying 128 J/cm(2) and a first-o

46 NAD(+), Pd-NPs and Nafion showed no loss of enzyme activity after preparation and demonstrated capab

47 , edaphic variables, and eight extracellular enzyme activities along six elevation transects in Tierr

48 s heteroannulation is entirely contingent on enzyme activity, although the mechanism of the requisite

49 The purified mitochondria were suitable for enzyme activity analyses and yielded sufficient amounts

50 DNA copy number as well as respiratory chain enzyme activities and levels.

51 Consistently, mitochondrial ETC enzyme activities and membrane potential were lowered in

52 mour cells, causing changes in mitochondrial enzyme activities and redox status that lead to apoptosi

53 ere found to have significantly reduced PPT1 enzyme activity and accumulate autofluorescent storage m

54 We also found decreased lysosomal enzyme activity and autophagic perturbations, suggesting

55 observed mutations were tested by measuring enzyme activity and by cell and animal models.

56 though temperature plays a critical role in enzyme activity and cross-bridge function.

57 l pH, which leads to impairment of lysosomal enzyme activity and disruption of autophagic processes.

58 T-A type glycosyltransferases, essential for enzyme activity and divalent cation coordination, we fou

59 nning datasets that measured the tradeoff of enzyme activity and enzyme stability.

60 Disease-induced changes in the antioxidant enzyme activity and fatty acid profile were also allevia

61 mal glucose-6-phosphate dehydrogenase (G6PD) enzyme activity and female patients with moderate G6PD e

62 Next, we design mutations that reduce the enzyme activity and finally design double mutations that

63 as associated with restoration of urea cycle enzyme activity and function, reduced hepatic ammonia, a

64 We assessed the enzyme activity and fungicide sensitivity for isolates i

65 57 analyzable patients found chitotriosidase enzyme activity and IL-6 to be significant independent p

66 origin and consequences of dysregulated PAD enzyme activity and immune responses against PAD enzymes

67 ften unclear but in some cases they regulate enzyme activity and metabolic homeostasis.

68 rough online biomonitoring, determination of enzyme activity and pancreatic hormones in plasma, histo

69 tanding of how climate influences N-fixation enzyme activity and physiology, comparatively little is

70 nes exhibited increases in GALNS protein and enzyme activity and reduced the size of enlarged lysosom

71 oordinating molecules, enabling control over enzyme activity and selectivity using small molecules.

72 concentration or KCl concentration decreases enzyme activity and sensor current.

73 he effects of single amino acid variation on enzyme activity and steady-state cellular abundance with

74 Ps = 1, E/MNPs = 0.11, pH = 6), the relative enzyme activity and the amount of enzyme immobilization

75 77, and Arg-303) that are important for both enzyme activity and the feedback inhibition by DHNA.

76 we investigated the role of each subunit on enzyme activity and the LCB product spectrum.

77 ted with homocysteinylation of eNOS, reduced enzyme activity and upregulation of caveolin-1 expressio

78 st-transcriptional events such as changes in enzyme activity and/or transport processes drove the obs

79 he micro-environments associated with higher enzyme activities, and greater abundance of such pores t

80 fluence soil microbial composition (MCC) and enzyme activities, and hence soil health.

81 arbon (C) as well as nitrogen (N) fractions, enzyme activities, and microbial community structure in

82 or change in the temperature sensitivity of enzyme activities, and no change in microbial carbon-use

83 Oxidative stress, endogenous enzyme activities, and other processes cause tens of tho

84 and residue incorporation on LOC fractions, enzyme activities, and the carbon pool management index

85 xisting techniques like sensory examination, enzyme activity, and colorimeter.

86 ved Thr241 in the kinase activation loop and enzyme activity, and preventing Thr241 phosphorylation c

87 s a 75% repression of BHMT mRNA, protein and enzyme activity, and significant depletion of hepatic be

88 This study aims to determine whether enzyme activities are correlated with protein amounts an

89 Cellular reporters of enzyme activity are based on either fluorescent proteins

90 able to confirm that 3-MPA inhibited PEPCK-M enzyme activity as 3-MPA interfered with the PEPCK enzym

91 th the LacZ gene encoding beta-galactosidase enzyme activity assay and Cre protein immunohistochemist

92 of strain B90A for alpha-HCH degradation in enzyme activity assay buffer.

93 We present an enzyme activity assay that allows the high-throughput ma

94 inhibitory concentrations (IC(50)) in a LOX enzyme activity assay.

95 ere validated by mitochondrial respirometry, enzyme activity assays and gene expression analyses.

96 Enzyme activity assays from stem-differentiating xylem (

97 However, enzyme activity assays revealed in all cultures that cel

98 In-frame deletions and enzyme activity assays were used to investigate the func

99 Enzyme activity assays with crude beetle protein extract

100 eosinophil function was determined by using enzyme activity assays, confocal microscopy, and short h

101 dation through site-directed mutagenesis and enzyme activity assays, we demonstrate here a synergisti

102 , 2, and 3 showed corresponding increases in enzyme activity assessed by PET of 13%, 56%, and 79%, an

103 sults identify a heretofore unknown cellular enzyme activity associated with Sts-1 and indicate that

104 ive and quantitative determination of repair enzyme activity at individual steps and over multiple st

105 46A1 at low drug levels while inhibiting the enzyme activity at the high dose used in clinical practi

106 proteins, suggesting the presence of altered enzyme activities based on substrate affinities.

107 We demonstrate utility with an enzyme activity based fluorescence "turn-ON" scheme.

108 Regulation of enzyme activity based on thiol-disulfide exchange is a r

109 t differences in Alcohol dehydrogenase (Adh) enzyme activity between and within several Drosophila sp

110 tion, regulating PXDN protein expression and enzyme activity both in vitro and in vivo.

111 utase and glutathione peroxidase antioxidant enzyme activities but maintains glutathione S transferas

112 Using mutations that block enzyme activity but have differential effects on Asn1p p

113 ide detailed insights into the regulation of enzyme activity by ACT domains and establish that it has

114 cription polymerase chain reaction, and PDE3 enzyme activity by cAMP-hydrolysis.

115 th in macrophages and that inhibition of PAD enzyme activity by Cl-amidine, a pan-PAD inhibitor, bloc

116 e aimed to protect and maintain subtilisin-A enzyme activity by exploring two pharmaceutical modifica

117 as an ALR2 inhibitor which primarily blocks enzyme activity by inhibiting substrate interaction of t

118 The increase in the enzyme activity by saponins, demonstrated here, is impor

119 Overall enzyme activity can be controlled by both protein expres

120 and the shelf-life testing result shows that enzyme activity can be maintained in PEG-DA over a long

121 tion of human pancreatic alpha-amylase (HPA) enzyme activity can offer facile routes to ameliorate po

122 evere G6PD deficiency were analyzed for G6PD enzyme activity, cellular oxidized nicotinamide adenine

123 splayed elevated liver mass (33%) and select enzyme activities compared to GC, whereas 21/22d-FLT mic

124 sphomimetic mutant form of GC-B also reduced enzyme activity, consistent with ATP stimulating guanyly

125 ated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydr

126 e summarize the available chemotaxonomic and enzyme activity data for diterpene synthases (diTPSs) in

127 or the use of mass cytometry for multiplexed enzyme activity detection.

128 abolished by a selective inhibitor of CYP2E1 enzyme activity (diallyl ether).

129 Interestingly, enzyme activities did not follow this pattern.

130 that aerated B. thetaiotaomicron loses some enzyme activities due to a high rate of endogenous super

131 ies but that are proven or predicted to lack enzyme activity due to mutations in otherwise conserved

132 elation analysis showed that CWEC, CWEN, and enzyme activities especially beta-Glucosidase activity w

133 The in situ enzyme activity evaluation was based on the ability of N

134 However, in striking contrast to the broad enzyme activity exhibited in vitro, we used a specialize

135 In this study, FMO enzyme activity experiments were conducted in vitro with

136 lation, microscopy, tissue-specific gene and enzyme activity expression with the analysis of hormones

137 Enzyme activities, flux measurements, hepatic metabolite

138 However, the problem is retention of high enzyme activity following enzyme fusion to the IgG.

139 as been developed using modulation of urease enzyme activity for detection of C-C mismatch single nuc

140 from its cytokine activity, MIF also harbors enzyme activity for keto-enol tautomerization.

141 is validated by quantitative measurements of enzyme activity for three different classes of enzymes (

142 ntrations, cytochrome b(5) reductase (CYB5R) enzyme activities, genotypes, and clinical signs in 30 d

143 Furthermore, the stabilization of enzyme activity has many practical applications in biote

144 The pre-targeted imaging of enzyme activity has not been reported, likely owing to t

145 Chitotriosidase enzyme activity holds promise as a biomarker for use in

146 echanisms for coupling droplet morphology to enzyme activity (host-guest interactions with uncaging a

147 s have been classically developed to inhibit enzyme activity; however, new classes of small molecules

148 This monovalent cation site controls enzyme activity: (i) PFL-AE in the absence of any simple

149 y acids and peroxide value, as indicators of enzymes activity, implied the effectiveness of treatment

150 ored OXPHOS protein levels and mitochondrial enzyme activities in C1qbp(-/-) MEFs.

151 ression as well as a different regulation of enzyme activities in comparison to the C(3) context.

152 MMP-2 enzyme activities in HGFs were also significantly increa

153 demonstrates a general method for measuring enzyme activities in lysates derived from individual cel

154 Measurements of enzyme activities in lysates prepared from transfected H

155 Direct measurements of circadian enzyme activities in mouse skeletal muscle confirmed tha

156 e organic carbon (LOC) fractions and related enzyme activities in soils are considered to be early an

157 omplex III revealed normal respiratory chain enzyme activities in the muscle of both patients.

158 of iron to purified DNMT in vitro decreased enzyme activity in a concentration-dependent manner.

159 y effective MR reporter for the detection of enzyme activity in a mouse model expressing beta-gal.

160 n oligomer sequence that maximally increased enzyme activity in all fibroblasts.

161 nscript, acid-alpha-glucosidase protein, and enzyme activity in all patients' myogenic cells, regardl

162 We reported previously lower NDEL1 enzyme activity in blood of treated first episode psycho

163 otype in normal rat strains, increased NDEL1 enzyme activity in blood.

164 h-throughput mass-spectrometric detection of enzyme activity in complex matrices without the need for

165 ffinity for folate and dramatically impaired enzyme activity in Forrest SHMT8.

166 he LPL-GPIHBP1 fusion protein exhibited high enzyme activity in in vitro assays.

167 Like etoposide, since PR-619 affected TOP2 enzyme activity in in vitro enzyme assays as well as in

168 D), a ubiquitously expressed membrane lipase enzyme activity in modulating phagocyte functions.

169 olative MR agents for the rapid detection of enzyme activity in mouse models expressing beta-galactos

170 as a highly sensitive detector by measuring enzyme activity in single cells.

171 nhibitor and finally to the determination of enzyme activity in some dietary supplements dedicated fo

172 onnections between metabolic and proteolytic enzyme activity in specific tumor compartments and patie

173 antly, these results support measuring NDEL1 enzyme activity in the peripheral blood to predict chang

174 that were evaluated for inhibition of CDPK1 enzyme activity in vitro and parasite growth in cell cul

175 he difficulty associated with reconstituting enzyme activity in vitro.

176 protein display in intact cells and inhibit enzyme activity in vitro.

177 enes to map the functional divergence of ADH enzyme activity in vivo, we find that amino acid substit

178 This was verified by inhibition of enzyme activity in whole cells after HAMLET but not ALA

179 ogen cold plasma treatments on the lipolytic enzymes activity in wheat germ were investigated.

180 In contrast, six different human E2 and E3 enzyme activities, including Cdc34 orthologs UBE2R1 and

181 diposity and SCD (stearoyl-CoA desaturase)-1 enzyme activity index.

182 esult in cell death; however, damping of the enzyme activity induces the formation 3D cell spheroids.

183 Direct measurement of DNA repair enzyme activities is important both for the basic study

184 found that (Pl)EctA forms a homodimer whose enzyme activity is highly regiospecific by producing N-g

185 Nuclear distribution element-like 1 (NDEL1) enzyme activity is important for neuritogenesis, neurona

186 have described a mode of regulation in which enzyme activity is modulated by polymerization into larg

187 es, but how these subunit isoforms influence enzyme activity is not clear.

188 The influence of the individual subunits on enzyme activity is not clear.

189 Fine control of enzyme activity is often delivered through post-translat

190 6 and by GR siRNA transfection and that DPP4 enzyme activity is reduced by DPP4 inhibitors.

191 In this study, we investigated whether PC enzyme activity is required for expression of the checkp

192 l membrane-tethered GALC (GALCLAMP1) retains enzyme activity, is able to cleave galactosylsphingosine

193 e single-cell phenotypic characterization of enzyme activity levels in Staphylococcus aureus.

194 RNA and enzyme activity levels in tissues recovered on-orbit wer

195 DBS from the PNPO-deficient samples showed enzyme activity levels lower than all samples from these

196 p mimics significantly decreased degradative enzyme activity levels while also decreasing expression

197 Assays of enzyme activities, lipid biomarkers, marker genes and mi

198 Finally, these insights into enzyme activity may also help to identify new transplant

199 Enzyme activity may be more pathophysiologically relevan

200 For example, an increase (or decrease) in enzyme activity may evolve from changes in protein seque

201 Further, enzyme activity may provide insights into rapid physiolo

202 could be fast-tracked by availability of an enzyme activity measurement method that is fast, label-f

203 Furthermore, we performed enzyme activity measurements and sensor measurements con

204 mitochondrial apo-aconitase 2 as assessed by enzyme activity measurements.

205 Plasma ADA2 enzyme activity normalized in those tested post-HSCT (7/

206 tered into the cisterna magna increased GALC enzyme activity, normalized psychosine concentration, im

207 ) and D6 WT and AD-associated mutants on the enzyme activities of KLK5 and KLK7 were compared using f

208 The enzyme activities of MMP-2 released from cells were exam

209 per-truncation, which correlated with higher enzyme activities of MPO in distinct granule populations

210 We demonstrate its use in improving the enzyme activities of not only N-type and O-type methyltr

211 ) level and leaf and root anatomy, inhibited enzyme activities of the ascorbate-glutathione cycle (wh

212 ergy metabolism, measuring bioenergetics and enzyme activities of the electron transport chain (ETC).

213 essments have involved testing for the total enzyme activity of aspartate aminotransferase (AST), lac

214 o compound has been reported to activate the enzyme activity of GPX4.

215 G6PDd was defined as an enzyme activity of less than 30%.

216 domain regulates both kinase and phosphatase enzyme activity of SrrB and present the structure of the

217 ransport to the cell wall and increasing the enzyme activity of Suc synthase.

218 The enzyme activity of the HIRMAb-enzyme fusion protein is p

219 reduction in the steady-state abundance and enzyme activity of the mitochondrial respiratory chain c

220 Fruit firmness, cell wall composition and enzyme activity of three apricot flesh zones were analys

221 biomarkers of oxidative stress, antioxidant enzyme, activities of Krebs cycle and respiratory chain

222 measurement of thiopurine methyltransferase enzyme activity or genotype before starting thiopurine t

223 that while NH(4)Cl and MgCl(2) do not affect enzyme activity or sensor performance in physiologically

224 biopsy, or postmortem brain at the level of enzyme activity or subunits.

225 We then measured oxidative enzyme activities, oxidative fibre density and capillari

226 t test results showed that, apart from soil enzyme activities (p > 0.05), the processes underlying E

227 s observed in time-course change patterns of enzyme activity, particularly for those acting on arabin

228 The organization of the enzyme activities performing these modifications differs

229 levels, including transcriptome, metabolome, enzyme activities, product accumulation, and tissue ultr

230 ug target engagement, as well as comparative enzyme activity profiling for basic and clinical applica

231 )Met polymorphism (rs4680) markedly affected enzyme activity, protein abundance, and protein stabilit

232 he capacity to identify and measure relevant enzyme activities provides fresh opportunities for under

233 Selection for a promiscuous enzyme activity provides substantial opportunity for com

234 hylase enzyme was partially inhibited (lower enzyme activity, reduction of formaldehyde accumulation)

235 ositively with indoleamine-2,3-dioxygenase-1 enzyme activity, regulatory T-cell frequency, activated

236 isms connecting DNA methylation patterns and enzyme activity remain elusive.

237 esterol (which represent 24- and 7-reductase enzyme activity, respectively) than those in Group 3 (p

238 zymes enables quantification of differential enzyme activity resulting from endogenous changes in loc

239 sence of the protease SPPL3 augmented B3GNT5 enzyme activity, resulting in upregulation of surface ne

240 ecific oxygen uptake rates and dehydrogenase enzyme activity results indicated that CAPB markedly imp

241 ively our findings dissociate levels of DPP4 enzyme activity, sDPP4 and biomarkers of inflammation in

242 Targeting MPO expression or enzyme activity sensitized AML cells to AraC treatment b

243 l analysis of electron transport chain (ETC) enzyme activities showed reduction in multiple ETC compl

244 2 treatment caused rapid suppression of 2B6 enzyme activity, significant HMM species generation, and

245 baseline and 6 months postprocedure assessed enzyme activity; standard assessments measured clinical

246 cid oxidation rate and greater mitochondrial enzyme activities, suggesting higher substrate availabil

247 Existing high-throughput assays for enzyme activity tend to be applicable only to a narrow r

248 ct timing separation constraints on rhythmic enzyme activities that allow for substantial rhythms in

249 4) photosynthesis entails the recruitment of enzyme activities that are not involved in photosyntheti

250 The contribution of various enzyme activities that collectively lead to the formatio

251 Enzyme activities that improve digestion of recalcitrant

252 ationship between conformational changes and enzyme activity that is exploited to achieve substrate s

253 biallelic variants in DHPS result in reduced enzyme activity that limits the hypusination of eIF5A an

254 mily members, leading to increased total SOD enzyme activity that positively contributed to higher H(

255 Among patients with normal G6PD enzyme activity, the decline in hemoglobin level with ta

256 ary tract and potentially augment pancreatic enzyme activity, the effect of ivacaftor on recurrent pa

257 ination of analysis on inhibition models and enzyme activity, the inhibition effect was suggested to

258 that their LysM and LytM domains enhance Rpf enzyme activity; their LytM domain and, in some cases th

259 replacements that entail deficiency of G6PD enzyme activity: they compromise the stability of the pr

260 enced fungal functional composition and soil enzyme activities through their direct effect on dissolv

261 potential mechanism for cross-regulation of enzyme activity through formation of competitive encount

262 06 and Asp571 for alanine residues abolishes enzyme activity, thus identifying the acid/base catalyti

263 The methodology seizes RNase H enzyme activity to degrade the upstream and downstream R

264 We review the adaptations of enzyme activity to different temperatures.

265 ses are partially inhibited by ADP, allowing enzyme activity to rapidly respond to changes in the lev

266 g the identification of novel substrates and enzyme activities towards the synthesis of monolignols.

267 and sublethal (respiration rate, antioxidant enzyme activity) toxicity in acute (96 h) copper and cad

268 est in designing spatiotemporal control over enzyme activities using noninvasive stimuli such as ligh

269 alize in mitochondria and produce higher PCC enzyme activity vs. single (PCCA or PCCB) mRNA alone.

270 APT-1 enzyme activity was decreased in endothelial cells from

271 GOT2 enzyme activity was deficient in fibroblasts with bi-all

272 No CHDH enzyme activity was detected in GV oocyte lysate, but CH

273 Antioxidant enzyme activity was enhanced in plants subjected to Cd.

274 Soil enzyme activity was inversely related to bacterial bioma

275 s study on a fish cell line, where the CYP1A enzyme activity was measured over time after exposure to

276 An in vitro Assay based on enzyme activity was used to detect cell viability, necro

277 Most of the enzymes' activity was promptly affected by the red light

278 ver, CO(2) efflux, N mineralisation rate and enzyme activities were all higher in invasive than nativ

279 The major antioxidant defence enzyme activities were largely stimulated by Si and SA,

280 Erythrocytic CYB5R enzyme activities were low in all dogs assayed.

281 By contrast, enzyme activities were minimally influenced by elevation

282 ghly sensitive: using HepG2 nuclear extract, enzyme activities were quantifiable at concentrations of

283 re similar in VOE platelets vs steady state, enzyme activities were significantly increased in VOE su

284 Simulations of enzyme activity were also performed and show how filamen

285 ion, and rhizosphere potential extracellular enzyme activity were assessed at vegetative, flowering a

286 n, PDE3A1 mRNA abundance and microsomal PDE3 enzyme activity were increased by 1.7-fold to 1.8-fold (

287 ing growth and tissue angiotensin-converting enzyme activity were programmed by paternal low protein

288 , taxonomic diversity and functioning (e.g., enzyme activity) were induced.

289 s was obviously decreased with weakened soil enzyme activities when compared to the healthy soils.

290 eterozygous carriers have a markedly reduced enzyme activity when compared to wild-type controls but

291 bably by inhibiting carbohydrate hydrolyzing enzyme activity which could be attributed to naringin.

292 se findings contrast with simply promiscuous enzyme activities, which have been described numerous ti

293 and TG6) having higher P5CS and lower ProDH enzyme activity, while group II plants had higher ProDH

294 na and exhibited free radical scavenging and enzyme activities with limited cytotoxicity and genotoxi

295 a nonlinear change in sensor performance and enzyme activity with increasing salt concentration.

296 sing rapid kinetic techniques to monitor the enzyme activity with its substrate dicyclotyrosine (cYY)

297 and TG2 line) had significant P5CS and ProDH enzyme activities, with group I plants (TG4 and TG6) hav

298 l approach for monitoring small-molecule and enzyme activities within living systems.

299 High-resolution maps of enzyme activity within tissues therefore represent power

300 al ET protein levels and concomitant reduced enzyme activity without affecting mRNA levels.