ライフサイエンスコーパス: eosinophil recruitment

1 uitment was replaced by augmentation of lung eosinophil recruitment.

2 other IL-13-mediated mechanisms critical for eosinophil recruitment.

3 s 1 and 2 lesions, with negligible effect on eosinophil recruitment.

4 antibody induced near complete inhibition of eosinophil recruitment.

5 eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment.

6 in vivo and thereby mediate T cell-dependent eosinophil recruitment.

7 nd IL-13, promoting Th2 cell development and eosinophil recruitment.

8 ng antibody partially reversed the defect in eosinophil recruitment.

9 IL-33, which induced both MTM activation and eosinophil recruitment.

10 mponent of the IL-33-ILCsIL-13-IL4Ra axis of eosinophil recruitment.

11 , innate lymphoid cells (ILCs), and IL4Ra in eosinophil recruitment.

12 and found that necrotic liver cells induced eosinophil recruitment.

13 of CCL11 (eotaxin), a chemokine involved in eosinophil recruitment.

14 and participate in lymphocyte activation and eosinophil recruitment.

15 receptors were essential for LTC4 to induce eosinophil recruitment.

16 as epithelial cells, are thought to initiate eosinophil recruitment.

17 oactive intestinal peptide (VIP), CRTH2, and eosinophil recruitment.

18 xpression of VIP in association with intense eosinophil recruitment.

19 creased mucin production and bronchoalveolar eosinophil recruitment.

20 ent mice demonstrates an identical defect in eosinophil recruitment.

21 -4-producing Th2 cells in ICOS-/- mice or in eosinophil recruitment.

22 levels, antigen-specific IgG1 response, and eosinophil recruitment.

23 g by regulation of lymphocyte activation and eosinophil recruitment.

24 more effective in blocking allergen-induced eosinophil recruitment.

25 veness to inhaled Ag, despite a reduction in eosinophil recruitment.

26 rotein, G(q), in the regulation of pulmonary eosinophil recruitment.

27 via a-CD90.2 administration did not decrease eosinophil recruitment 24 h and 7 d after MWCNT exposure

28 alpha-CD90.2 administration did not decrease eosinophil recruitment 24 h and 7 d after MWCNT exposure

29 es the magnitude of the early (but not late) eosinophil recruitment after antigen challenge in models

30 Histologic indices of lung inflammation (eg, eosinophil recruitment, airway and vessel wall thickenin

31 L11 (eotaxin-1) regulate critical aspects of eosinophil recruitment, allergic inflammation, and airwa

32 Although eosinophil recruitment and activation were increased in

33 hil activation status, and induction of lung eosinophil recruitment and activation.

34 3) has been shown to play a critical role in eosinophil recruitment and airway allergic inflammation

35 uation of cellular mediators associated with eosinophil recruitment and airway remodeling revealed th

36 ion, mice deficient in eotaxin have impaired eosinophil recruitment and are protected from gastromega

37 We demonstrate that aeroallergen-induced eosinophil recruitment and chemokine production were lar

38 r, the functional role of TrkA in regulating eosinophil recruitment and contributing to AAI is poorly

39 s, and injections of anti-IL-5 mAb prevented eosinophil recruitment and crystal deposition but did no

40 ngs suggest a possible role for TNF-alpha in eosinophil recruitment and cytokine expression in this d

41 Lack of GM-CSF also resulted in reduced eosinophil recruitment and delayed recruitment of mononu

42 Eosinophil recruitment and enhanced nitric oxide (NO) pr

43 Eosinophil recruitment and enhanced production of NO are

44 hours after SBP-Ag to identify regulation of eosinophil recruitment and Feno changes.

45 nary fibrosis via induction of IL-5-mediated eosinophil recruitment and fibrogenic cytokine productio

46 GPR35 deficiency dampened eosinophil recruitment and fungal growth, whereas overex

47 ion through IL-17-independent suppression of eosinophil recruitment and IL-17-dependent regulation of

48 Eosinophil recruitment and inhibition of fungal clearanc

49 ice, lead us to suggest that deficiencies in eosinophil recruitment and isotype switching to IgE prod

50 The potent inhibitory effects on eosinophil recruitment and late-phase inflammation sugge

51 odulated ongoing AHRs considerably, reducing eosinophil recruitment and methacholine responsiveness,

52 Eosinophil recruitment and mucus hypersecretion are char

53 istration of IL-5 restored the impairment of eosinophil recruitment and mucus production in OVA-chall

54 A2BAR exhibited decreased M2 macrophage and eosinophil recruitment and reduced IL-4 and IL-13 cytoki

55 ethasone, which has been reported to inhibit eosinophil recruitment and shrink GBM lesions on contras

56 ype was responsible for MWCNT-induced airway eosinophil recruitment and subsequent sex differences in

57 However, the kinetics of eosinophil recruitment and the development of AHR are no

58 re of chitin in germinating conidia promotes eosinophil recruitment and ultimately induces Th2-skewed

59 of chemokine-, IL-13-, and allergen-induced eosinophil recruitment and, conversely, neutralization o

60 o orally available drugs aimed at preventing eosinophil recruitment and, hence, the pathogenesis asso

61 cient mice ( approximately 75% inhibition of eosinophil recruitment) and ICAM-1-deficient mice ( appr

62 8 (neutrophil/eosinophil chemotaxis), CCL24 (eosinophil recruitment), and CXCL12 (lymphocyte recruitm

63 nteract to increase Th2 cytokine production, eosinophil recruitment, and airway hyperresponsiveness i

64 creased Th2 cytokine production, IgE levels, eosinophil recruitment, and airway mucus, demonstrating

65 secreting cells, diminished allergen-induced eosinophil recruitment, and decreased the number of ragw

66 cludes macrophage activation, neutrophil and eosinophil recruitment, and elevated KC, TNF-alpha, and

67 ling on proinflammatory cytokine production, eosinophil recruitment, and hepatocellular apoptosis.

68 otype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction.

69 reatment efficacy was assessed by evaluating eosinophil recruitment, antibody, and cytokine productio

70 Such impairment of eosinophil recruitment appeared to take place after IgE

71 Since the molecular mechanisms controlling eosinophil recruitment are incompletely understood, we p

72 ary and sufficient chemokine responsible for eosinophil recruitment around TEBs.

73 current with a restoration of macrophage and eosinophil recruitment around the growing ducts.

74 t to date dissecting compartmentalization of eosinophil recruitment as it unfolds during allergic inf

75 e degree of eosinophilia, the BALF levels of eosinophil recruitment-associated cytokines were signifi

76 To contrast eosinophil recruitment between these two compartments, w

77 In males, Fulvestrant did not affect eosinophil recruitment but reduced IL-33 and M2a genes c

78 suggest that PARP-1 plays a critical role in eosinophil recruitment by specifically regulating the ca

79 ctivation of TrkA and its role in regulating eosinophil recruitment by using a chemical-genetic appro

80 We revealed mechanisms of macrophage-eosinophil recruitment, CD4(+) and CD8(+) T cell dysregu

81 Eosinophil recruitment, cytokine production, serum immun

82 and inflammation defects, but the granuloma eosinophil recruitment defect persisted when donor cells

83 er TrkA-activating mediators, contributes to eosinophil recruitment during AAI and suggests that targ

84 ediators and adhesion molecules orchestrates eosinophil recruitment during allergic inflammation in t

85 make MCP-4 a candidate for playing a role in eosinophil recruitment during allergic respiratory disea

86 In summary, CXCR4 blockade inhibited eosinophil recruitment during type-2 granuloma formation

87 ment and activation of Th2 cells, leading to eosinophil recruitment, even in the absence of challenge

88 elial cells require H2R to produce CCL24, an eosinophil recruitment factor, whereas H2R blockade redu

89 long with serial elaboration of monocyte and eosinophil recruitment factors.

90 Bronchial inflammatory cell (lymphocyte and eosinophil) recruitment has been demonstrated.

91 cytokines involved in macrophage migration, eosinophil recruitment, humoral and adaptive immunity, n

92 This Review explores eosinophil recruitment, immune interactions, therapeutic

93 ddress the endogenous mechanisms involved in eosinophil recruitment in a late-phase allergic reaction

94 or endogenous eotaxin in mediating the 111In-eosinophil recruitment in allergic inflammation, and sug

95 The mechanisms of selective eosinophil recruitment in allergic reactions are not ful

96 The accelerated eosinophil recruitment in allergic subjects provides sup

97 Eosinophil recruitment in asthma is a multistep process,

98 ion of allergic inflammation with diminished eosinophil recruitment in BAL and lung and reduced mucus

99 Eosinophil recruitment in BAL was significantly reduced

100 1 plays a critical role in the regulation of eosinophil recruitment in colonic eosinophilic disease s

101 These results demonstrate that eosinophil recruitment in EAE is dependent on LTB4 recep

102 damental role of the eotaxin/CCR3 pathway in eosinophil recruitment in experimental asthma.

103 endothelium contributed to the inhibition of eosinophil recruitment in IL-1 receptor type 1-deficient

104 Bronchoalveolar lavage (BAL) eosinophil recruitment in IL-1 receptor type 1-deficient

105 -5, or mMIP-1beta, induced significant 111In-eosinophil recruitment in mouse skin.

106 caspofungin that was associated with airway eosinophil recruitment in neutropenic mice with invasive

107 kine eotaxin is likely to be associated with eosinophil recruitment in onchodermatitis, DEC was appli

108 Eosinophil recruitment in P-selectin-deficient mice ( ap

109 lung transcriptome and proteome during peak eosinophil recruitment in postnatal development, we iden

110 Eosinophil recruitment in response to conidial aspiratio

111 investigated chemokine receptor CCR3-induced eosinophil recruitment in sialyltransferase St3gal4(-/-)

112 ith metRANTES, significantly inhibited 111In-eosinophil recruitment in the allergic reaction.

113 -3 contributes to a significant component of eosinophil recruitment in the type-2 interstitial granul

114 an antiMIP-1alpha antibody, suppressed 111In-eosinophil recruitment in this delayed-onset allergic re

115 and may play an important role in mediating eosinophil recruitment in various allergic conditions in

116 of the hookworm Necator americanus inhibited eosinophil recruitment in vivo in response to eotaxin, b

117 important role of ST3Gal-IV in CCR3-induced eosinophil recruitment in vivo rendering this enzyme an

118 The role of selectins in mediating eosinophil recruitment in vivo was assessed in a model o

119 5 production by lung leukocytes in vitro and eosinophil recruitment in vivo.

120 hil is essential for chemoattractant-induced eosinophil recruitment in vivo.

121 osinophil aggregation in vitro and cutaneous eosinophil recruitment in vivo.

122 Here, we describe a novel mouse model of eosinophil recruitment in which we have compared the in

123 d type 2 T cell-dependent responses (IgE and eosinophil recruitment) in a model of allergic pulmonary

124 that SATB1 upregulated the genes involved in eosinophil recruitment, including signal transducer and

125 injection and subsequently declined, whereas eosinophil recruitment increased as time elapsed and com

126 ODN in IFN-gamma -/- mice failed to inhibit eosinophil recruitment, indicating a critical role of IF

127 ted in P-selectin/ICAM-1 double-mutant mice (eosinophil recruitment inhibited approximately 62%).

128 d-specific IL4Ra deficiency on IL-13-induced eosinophil recruitment into adult lung airspaces.

129 and may play an important role in mediating eosinophil recruitment into inflammatory foci.

130 Eotaxin, which is a major mediator for eosinophil recruitment into lung, has regulatory effects

131 Eosinophil recruitment into the airspaces was elevated i

132 Allergen-induced eosinophil recruitment into the airway was abolished by

133 re was a fourfold increase in IL-13-mediated eosinophil recruitment into the airway.

134 CCL11, and CCL24 and for Th2 lymphocyte and eosinophil recruitment into the allergic airway.

135 In vivo R321 effectively blocks eosinophil recruitment into the blood, lungs, and airway

136 re was a profound reduction in IL-13-induced eosinophil recruitment into the lung lumen.

137 eosinophil-attracting chemokines and reduced eosinophil recruitment into the lung, which was benefici

138 Oral administration of 32 reduced eosinophil recruitment into the lungs in a dose-dependen

139 n and the RSV-G glycoprotein, suppressed the eosinophil recruitment into the lungs of these mice upon

140 ely expressed in the gastrointestinal tract, eosinophil recruitment into the small intestine was abla

141 through CCR3 is a key regulatory pathway for eosinophil recruitment into tissues associated with alle

142 Selective eosinophil recruitment into tissues is a characteristic

143 Increased eosinophil recruitment is a hallmark feature of eosinoph

144 Eosinophil recruitment is a hallmark of parasitic infect

145 Eosinophil recruitment is a pathological hallmark of man

146 Furthermore, in the absence of eotaxin, eosinophil recruitment is attenuated, whereas in the abs

147 ce, suggesting that Aspergillus-induced lung eosinophil recruitment is regulated by IL-13-induced che

148 Selective eosinophil recruitment is the result of orchestrated eve

149 alization of interleukin-5 (IL-5) to inhibit eosinophil recruitment likewise had no effect on early c

150 geting the TrkA signaling pathway to inhibit eosinophil recruitment may serve as a therapeutic strate

151 n eosinophil development (Deltadbl-GATA) and eosinophil recruitment [mice deficient in CCR3 (CCR3 kno

152 have significantly increased neutrophil and eosinophil recruitment, mucin production and asthma-asso

153 Eosinophil recruitment occurred more rapidly in allergic

154 hase with expression of surface integrins on eosinophils, recruitment of eosinophils from the bone ma

155 elial collagen deposition, but did not alter eosinophil recruitment or the alternative activation of

156 hil recruitment, but significantly inhibited eosinophil recruitment (p = 0.0032).

157 TNC knockout mice had an altered eosinophil recruitment profile in development.

158 Ligand-receptor expression uncovers eosinophil recruitment programs, increased fibroblast in

159 e findings demonstrate that Nb-initiated FGT eosinophil recruitment promotes an eosinophil, IL-33, an

160 Eosinophil recruitment, Th2 and Th17 cytokine and chemok

161 ct (BPE)-induced allergic lung inflammation, eosinophil recruitment, Th2-related cytokine and chemoki

162 ILC2 activation and eosinophil recruitment, TH2-related cytokine and chemoki

163 inking inflammatory cytokine mobilization to eosinophil recruitment that may be relevant to the patho

164 erized by ILC2 activation, proliferation and eosinophil recruitment that was associated with accelera

165 r signaling on platelets to markedly amplify eosinophil recruitment through pulmonary vascular adhesi

166 ficiency led to increased lung inflammation, eosinophil recruitment, tissue pathology, and collagen d

167 Thus, signaling via CCR3 mediates eosinophil recruitment to airway nerves and may be a pre

168 This study suggests that Gal-1 can limit eosinophil recruitment to allergic airways and suppresse

169 Moreover, eosinophil recruitment to both the lung and peritoneum i

170 , CCL28 appears to play a role in regulating eosinophil recruitment to peribronchial regions of the l

171 , an integrin counter-receptor implicated in eosinophil recruitment to the airway in asthma.

172 ism appears to be by specifically inhibiting eosinophil recruitment to the airway nerves.

173 bronchoconstriction, since it would decrease eosinophil recruitment to the airway nerves.

174 phenotype in lung tissue was associated with eosinophil recruitment to the airways, as all BAL eosino

175 s lower in CXCR2(-/-) mice than BALB/c mice, eosinophil recruitment to the cornea was not impaired.

176 ustained O. volvulus keratitis by regulating eosinophil recruitment to the cornea.

177 that P-selectin is an important mediator of eosinophil recruitment to the cornea.

178 iver blindness (Onchocerca volvulus) induces eosinophil recruitment to the corneal stroma at the time

179 ntly, IL-36R signaling induced CCL7-mediated eosinophil recruitment to the inflamed skin.

180 rast, CCR3 disruption significantly curtails eosinophil recruitment to the lung after allergen challe

181 , significantly reduced the intensity of the eosinophil recruitment to the lung and airway during the

182 Eosinophil recruitment to the lung was also significantl

183 CAR4-deficient mice did not have a defect in eosinophil recruitment to the lung, nor a change in eosi

184 generation and is associated with decreased eosinophil recruitment to the lung.

185 induced airway hyperreactivity and decreased eosinophil recruitment to the lungs as effectively as de

186 -OI alleviated airway resistance and reduced eosinophil recruitment to the lungs.

187 Eosinophil recruitment to the metastatic sites in the lu

188 , OVA, in mice, including Ag-specific recall eosinophil recruitment to the peritoneum.

189 f the adaptive immune system, contributes to eosinophil recruitment to the site of larval infection,

190 suggest that CCR3 plays an essential role in eosinophil recruitment to the skin and the lung and in t

191 t helminths may employ mechanisms to inhibit eosinophil recruitment, to prolong worm survival in the

192 Significant 111In-eosinophil recruitment was also observed in an active cu

193 filarial nematode infection, optimum tissue eosinophil recruitment was coordinated by local macropha

194 and eotaxin-1/2(-/-) mice demonstrated that eosinophil recruitment was dependent on eotaxin-1.

195 developed normally and that the reduction in eosinophil recruitment was likely due to systemic reduct

196 Eosinophil recruitment was not completely inhibited in P

197 psies at 30 min and 6 h, whereas significant eosinophil recruitment was observed in allergic subjects

198 Eosinophil recruitment was partially reduced (54%) by th

199 d to mature for 3 wk, the inhibition of lung eosinophil recruitment was replaced by augmentation of l

200 cient mice ( approximately 67% inhibition of eosinophil recruitment) was significantly reduced compar

201 mice to synthesize GM-CSF, a key cytokine in eosinophil recruitment, was reestablished by replenishme

202 ht to be the principal orchestrating cell in eosinophil recruitment, we evaluated its presence in the

203 like molecule beta (RELMbeta) expression and eosinophil recruitment, which are two mechanisms that el