ライフサイエンスコーパス: ependymal cell

1 d indirectly by RFX1, RFX2 and RFX3 in mouse ependymal cells.

2 rity that predicts the orientation of mature ependymal cells.

3 ial glia and then refined by motile cilia in ependymal cells.

4 ly in and induce cellular damage in infected ependymal cells.

5 reduced the injury-induced proliferation of ependymal cells.

6 hat share cellular adherens with neighboring ependymal cells.

7 eta were detected in adult CP, as well as on ependymal cells.

8 rogenesis from postnatal SVZ progenitors and ependymal cells.

9 lia in various stages of transformation into ependymal cells.

10 eep in zebrafish, probably via activation of ependymal cells.

11 icular wall transform to give rise to mature ependymal cells.

12 ytes, astrocytes, and the choroid plexus and ependymal cells.

13 ere was positive staining in the ventricular ependymal cells.

14 racic spinal cord is located on neurones and ependymal cells.

15 ian brain ventricles are lined with ciliated ependymal cells.

16 ion and spread caudally without infection of ependymal cells.

17 days postinfection, with no apparent loss of ependymal cells.

18 blasts, immature precursors, astrocytes, and ependymal cells.

19 rally similar to the mammalian multiciliated ependymal cells.

20 microglial activation when PV is absent from ependymal cells.

21 ne and revealed cell cycle synchrony between ependymal cells.

22 rs) and Cx43 coupling, were also analyzed in ependymal cells.

23 l cycle arrest (G0) and begin to mature into ependymal cells.

24 , smooth muscle, perivascular fibroblast and ependymal cells.

25 ytoskeletal protein, to reduce the volume of ependymal cells.

26 cts caused by uncoordinated cilia beating in ependymal cells.

27 and neurogenesis as well as the formation of ependymal cells.

28 tive phenotype, similarly to injury-reactive ependymal cells.

29 ngly, mWAKE is also observed in non-neuronal ependymal cells.

30 is expressed in the astrocytic end feet and ependymal cells.

31 f Chlamydomonas flagella and motile cilia in ependymal cells.

32 stricted to Purkinje neurons and a subset of ependymal cells.

33 ave both redundant and specific functions in ependymal cells.

34 two distinct cell populations: tanycytes and ependymal cells.

35 y confined to large ventral horn neurons and ependymal cells.

36 pical endfeet in the center of a pinwheel of ependymal cells.

37 aintenance of choroid plexus vasculature and ependymal cells.

38 tein (BMP) antagonist Noggin is expressed by ependymal cells adjacent to the SVZ.

39 patial distribution and migratory pattern of ependymal cells after injury.

40 n endothelial cells, inflammatory cells, and ependymal cells after intracerebral inoculation of NSV.

41 Timely generation and normal maturation of ependymal cells along the aqueduct are critical for prev

42 or for generating developmentally controlled ependymal cells along the ventricular lining of the aque

43 It has been suggested that ependymal cells also function as stem cells.

44 ytes, but recent evidence has suggested that ependymal cells also participate.

45 lammasome assembly in multiciliated FoxJ1(+) ependymal cells and a loss of the ependymal border in th

46 get genes to regulate the differentiation of ependymal cells and a small subset of astrocytes in the

47 in mice is required for differentiation into ependymal cells and a small subset of FoxJ1(+) astrocyte

48 icular zones of the brain differentiate into ependymal cells and astrocytes.

49 t to the SC, where it is expressed mainly by ependymal cells and by small-diameter axons located in t

50 th markedly increased potency in transducing ependymal cells and cerebral neurons in NHPs.

51 In conclusion, loss of ependymal cells and ciliary function exposes the underly

52 birth and early stages in the maturation of ependymal cells and demonstrates that these cells are de

53 patch clamp single motile cilia of mammalian ependymal cells and examine their potential function as

54 d neurons, astrocytes, oligodendrocytes, and ependymal cells and hence did not discriminate among CNS

55 cell types, whereas Pcm1(-/-) multiciliated ependymal cells and human PCM1(-/-) retinal pigmented ep

56 by astrocytes in the adult brain except for ependymal cells and in the neurogenic regions, where SOX

57 ments reveal that they also make astrocytes, ependymal cells and interneurons.

58 Het CKO mice had decreased ependymal cells and Mpp5 at the apical surface of cortic

59 e, in animal tissues, (ii) that infection of ependymal cells and neuroblasts provides a route by whic

60 The fused gene is expressed highly in ependymal cells and the choroid plexus, tissues involved

61 terestingly, we found that the maturation of ependymal cells and the formation of cilia occur signifi

62 , osteocytes, glandular myoepithelial cells, ependymal cells, and by stromal reticular cells and foll

63 s, including neurons, glial cells, meninges, ependymal cells, and cells of cerebral vessels.

64 le in the hypothalamus, including tanycytes, ependymal cells, and certain neuron types in the arcuate

65 ected in a subset of GFAP+ astroglial cells, ependymal cells, and Dlx2+ precursors in the SVZ.

66 ain gene Mdnah5 is specifically expressed in ependymal cells, and is essential for ultrastructural an

67 e Hassall's corpuscles), and brain (neurons, ependymal cells, and macrophages) revealed the presence

68 e all highly expressed in choroid plexus and ependymal cells, and most have been associated with cili

69 of adult male mice--albeit with NSCs nearer ependymal cells--and that distance from the ventricle is

70 Our results indicate that ependymal cells are born in the embryonic and early post

71 Most ependymal cells are born prenatally and are derived from

72 localized to the ependyma, although not all ependymal cells are CD133(+).

73 Ependymal cells are functionally heterogeneous with a mi

74 Ependymal cells are generated from radial glia cells dur

75 Ependymal cells are LeX(-), and purified ependymal cells

76 ells in the alpha2 tanycytic zone, where few ependymal cells are normally found, suggesting that Rax

77 Ependymal cells are part of the neurogenic niche in the

78 Our findings suggest that connexins in ependymal cells are potential targets to improve self-re

79 , and a late phase, in which only additional ependymal cells are produced.

80 results suggest that PCNA and late dividing ependymal cells are required for normal CNS development

81 Ependymal cells are, however, heterogeneous, and the bio

82 We demonstrate that DNGR-1-lineage-traced ependymal cells arise early in embryogenesis (E11.5) and

83 erneurons in laminae I and II, as well as in ependymal cells around the central canal.

84 RV produces specific and easily identifiable ependymal cell as well as neuronal labeling following ve

85 gene cebpd was upregulated remotely in brain ependymal cells as well as kidney tubular cells, in addi

86 , these antibodies also labeled rat pial and ependymal cells as well as reactive astrocytes adjacent

87 and patterning of hypothalamic tanycytes and ependymal cells, as well as for maintenance of the cereb

88 f uniciliated, biciliated, and multiciliated ependymal cells, astrocytes, and neurons.

89 uring the acute phase of infection including ependymal cells, astrocytes, microglia, oligodendroglia,

90 ciency of the proteoglycan Tsukushi (TSK) in ependymal cells at the LV surface and in the cerebrospin

91 types of astrocytes and a group of displaced ependymal cells between Layers II and III.

92 icate that, unlike cuboidal ependymal cells, ependymal cells bordering the CVOs possess long processe

93 ephalus or prevent the formation of ciliated ependymal cells but caused defects in their differentiat

94 TrkB-TR is expressed in SVZ astrocytes and ependymal cells, but not in neuroblasts.

95 n ventricular progenitors destined to become ependymal cells, but not in NSCs, and is required for SV

96 sured CaV1 voltage-gated calcium channels in ependymal cells, but these channels are not specifically

97 neuronal cell nuclei at distant sites and to ependymal cells by cerebrospinal fluid, (iii) the virus

98 Our characterisation of adult ependymal cells by single-cell RNA sequencing and histol

99 the developmental origin of postnatal spinal ependymal cells by studying the dynamic expression of se

100 in the hypothalamus is formed by specialized ependymal cells called the tanycytes.

101 rd ventricle, which is formed by specialized ependymal cells, called tanycytes.

102 gene therapy to long-lived, ventricle-lining ependymal cells can profoundly affect disease phenotypes

103 Our data show that ependymal cells can serve as a source of enzyme secretio

104 The loss of p11 in ependymal cells causes disoriented ependymal planar cell

105 a developmental-like program in spinal cord ependymal cells, characterized by a high-proliferation z

106 ngl2 in foxj1a-positive cell lineages causes ependymal cell cilia and Reissner fiber formation defect

107 evelopmental model of IS, exhibit defects in ependymal cell cilia development and cerebrospinal fluid

108 Ultrastructural examination of the ependymal cell cilia that line the enlarged third ventri

109 lation in the CSF, we impair the motility of ependymal cell cilia.

110 ible roles for ASPM in sperm flagellar or in ependymal cells' cilia.

111 scuss how hyperglycemia temporarily modifies ependymal cell ciliary beating to increase hypothalamic

112 ing approaches, we demonstrate that CD133(+) ependymal cells continuously produce new neurons destine

113 cal recombinant human HB-EGF delivery alters ependymal cell cycling and tissue bridging, enhancing fu

114 r was also observed in young mice after mild ependymal cell denudation with low dosages of neuraminid

115 with increased KLF4 in NSCs and NSCs-derived ependymal cells developed hydrocephalus-like characteris

116 whether this organization is acquired during ependymal cell development or is already present in radi

117 Dystroglycan is furthermore required for ependymal cell differentiation and assembly of niche pin

118 Foxj1, a transcription factor that promotes ependymal cell differentiation.

119 ax is required for hypothalamic tanycyte and ependymal cell differentiation.

120 l ventricles, and uniciliated and biciliated ependymal cells display cilia with large, star-shaped ba

121 using Nestin-Cre prevented the formation of ependymal cells, disrupting cerebrospinal fluid flow and

122 ependymal ciliary beat frequency and caused ependymal cell disruption.

123 Ependymal cells are LeX(-), and purified ependymal cells do not make neurospheres, resolving the

124 new role and a key molecular determinant for ependymal cell-driven CSF flow in mood disorders and sug

125 o the ventricular surface of differentiating ependymal cells during FoxJ1-dependent ciliogenesis.

126 CC lining serves as a source of cells beyond ependymal cells during the first postnatal weeks of the

127 The homeobox gene Six3 is expressed in ependymal cells during the formation of the lateral wall

128 se is consistent with a signal that recruits ependymal cells during ~85 hours after amputation within

129 cyte progenitor cells (OPCs), astrocytes and ependymal cells-during multiple sclerosis and other CNS

130 contacts between 5HT axons and NSCs (B1) or ependymal cells (E1) and these cells were labeled by a t

131 Our data indicate that, unlike cuboidal ependymal cells, ependymal cells bordering the CVOs poss

132 Similarly, Pcm1(-/-) ependymal cells exhibited reduced removal of CP110 from

133 Our simulations show that ependymal cells experience a loading state that causes t

134 trocytes, Iba-1(+) microglia and S100beta(+) ependymal cells expressed PLIN in the aging brain.

135 In its absence, ependymal cells fail to suppress radial glia characteris

136 aced cells are quiescent, committed to their ependymal cell fate, and do not contribute to neuronal o

137 ntricle-contacting NSCs, which together with ependymal cells form regenerative units (pinwheels) alon

138 We simulated the mechanical loading of the ependymal cells forming the primary brain-fluid interfac

139 share the "shoreline" on the ventricles with ependymal cells, forming a unique adult ventricular zone

140 S100B+/PV+ ependymal cells found in younger mice diminished in the

141 le-cell transcriptomic census of spinal cord ependymal cells from adult and aged mice, identifying no

142 cal characteristics similar to multiciliated ependymal cells from the lateral ventricles, and unicili

143 involved in the regulation of EC stability, ependymal cell function, and periventricular permeabilit

144 Ependymal cells have a remarkable planar polarization th

145 findings highlight previously unappreciated ependymal cell heterogeneity and identify across the ent

146 In addition, we suggested that the Nkx6.1+ ependymal cells in adult mouse spinal cords may retain t

147 This suggests an involvement of PV+ ependymal cells in aging-associated ventricle stenosis.

148 PV and display phenotype shift to "reactive" ependymal cells in aging-related ventricle stenosis; mor

149 ia of respiratory epithelial cells and brain ependymal cells in both mice and humans.

150 Application of 5-HT to ependymal cells in cultured rat brainstem slices caused

151 esulted in CBF responses similar to those of ependymal cells in cultured slices suggesting that these

152 transgene, defines neurons, subependymal, or ependymal cells in discrete locations throughout the neu

153 mRNA to determine the role of late dividing ependymal cells in embryos of the ascidian Styela clava.

154 also observed in some endothelial cells and ependymal cells in HIVE CNS.

155 ried out by astrocytes, oligodendrocytes and ependymal cells in other CNS regions.

156 cell niche to repair.SIGNIFICANCE STATEMENT Ependymal cells in the adult spinal cord are latent prog

157 Ependymal cells in the adult spinal cord become activate

158 ver, GFP expression persisted in a subset of ependymal cells in the adult spinal cord, suggesting tha

159 ncy also resulted in the ectopic presence of ependymal cells in the alpha2 tanycytic zone, where few

160 n inflammatory cells, endothelial cells, and ependymal cells in the central nervous system of infecte

161 certain nonneuronal cell populations such as ependymal cells in the choroid plexus.

162 We further analyze ependymal cells in the human spinal cord and identify wi

163 d choroid epithelial cells diminished, while ependymal cells in the lateral and fourth ventricles sho

164 Here we show that basal bodies in ependymal cells in the lateral ventricle walls of adult

165 16 is required for the formation of ciliated ependymal cells in the lateral ventricle.

166 However, PV+ ependymal cells in the LV-wall adhesions, unlike injury-

167 sion in the cortex and striatum, and in most ependymal cells in the ventricular and subventricular zo

168 Here, we find that ependymal cells in zebrafish spinal cords produce the ne

169 We find that coupling among ependymal cells is downregulated as postnatal developmen

170 stin immunoreactivity in glial, neuronal and ependymal cells is suggestive of a protein expression pa

171 eased expression of DIO2 in the hypothalamic ependymal cell layer containing tanycytes.

172 Furthermore, the ependymal cell layer does not form in the conditional kn

173 a role supported by the loss of cilia on the ependymal cell layer in ventricles of Tg737(orpk) brains

174 Hydin expression is confined to the ciliated ependymal cell layer lining the lateral, third and fourt

175 Before their migration through the ependymal cell layer, a subset of these infected myeloid

176 larged ventricles, partial denudation of the ependymal cell layer, altered subcommissural organ morph

177 ells infected with CVB3 migrated through the ependymal cell layer, they revealed distinct morphologic

178 injection site, possibly associated with the ependymal cell layer.

179 the lateral ventricular wall: a monolayer of ependymal cells (Layer I), a hypocellular gap (Layer II)

180 the murine brain stem and subsequently brain ependymal cells, leading to enlargement of the cerebral

181 Ciliated ependymal cells line the ventricular surfaces and aquedu

182 Multiciliated epithelial cells, called ependymal cells, line the ventricles in the adult brain.

183 Ependymal cells lining the brain ventricles also carry m

184 s expressed by choroid plexus epithelium and ependymal cells lining the brain ventricles and neural t

185 ventricles depends on cilia motility of the ependymal cells lining the brain ventricles, which play

186 Recent studies have suggested that the ependymal cells lining the central canal of postnatal sp

187 f the DRG, by most neurons of the SC, and by ependymal cells lining the central canal.

188 ved in the pia matter, on a subpopulation of ependymal cells lining the cerebral ventricle wall, and

189 ese other cells included patches of ciliated ependymal cells lining the lateral ventricles and many i

190 nt LV cells, which are situated close to the ependymal cells lining the LVs, are activated by choline

191 , which contains glucosensing neurons, or in ependymal cells lining the third ventricle, where others

192 qually distributed within microglia, and the ependymal cells lining the ventricles of the brain expre

193 icles and deceleration of ciliary beating on ependymal cells lining the ventricular walls.

194 gth and beating frequency of motile cilia on ependymal cells lining ventricles.

195 Ciliated ependymal cells loaded with caged cAMP exhibited a 54.3

196 Sox2 and Sm-Sox19 were strongly expressed in ependymal cells located in neurogenic niches revealed by

197 brains of adult C57BL/6 mice and found that ependymal cells located in the adhesions of the medial a

198 Here, we show that Six3 is necessary for ependymal cell maturation during postnatal stages of bra

199 is accompanied by a short-lived reversal of ependymal cell maturation.

200 s became apparent and prior to multiciliated ependymal cell maturation.

201 , endothelial cells, tanycytes, radial glia, ependymal cells, microglia, and cells from the meninges

202 endothelium, as well as the disappearance of ependymal cell microvilli and the development of periven

203 Ependymal cells normally form the epithelial layer encas

204 We found that PrPSc was present in the ependymal cells of both 263K- and 139H-infected hamsters

205 (Sm-Sox2) and Sm-Sox19 mRNAs was detected in ependymal cells of different regions of the telencephalo

206 fects in the motile cilia of the ventricular ependymal cells of mutants, suggesting a role for Katnal

207 Our findings implicate that compromised ependymal cells of the adhering ependymal layers upregul

208 These biciliated ependymal cells of the central canal (Ecc) resembled E2

209 Staining was most prominent in the ependymal cells of the choroid plexus, Purkinje cells of

210 retinoic acid (RA) within the tanycytes and ependymal cells of the hypothalamus have been implicated

211 cause Noggin expression is restricted to the ependymal cells of the lateral ventricles, where FXR2 is

212 ta homologue is expressed in the ventralmost ependymal cells of the neural tube, while the Ciona snai

213 form the secondary tail muscle, the lateral ependymal cells of the spinal cord, and the dorsal cells

214 GLUT2 immunoreactivity was seen in the ependymal cells of the third ventricle and in scattered

215 d, with Na,K-ATPase, in certain tanycytes or ependymal cells of the ventricle wall.

216 gene expression in circumventricular organs; ependymal cells of the ventricles, meninges, and choroid

217 Ependymal cells of wild-type ventricles strongly express

218 Ependymal cells on the walls of brain ventricles play es

219 Aging-associated ependymal-cell pathologies can manifest as ventricular g

220 Interestingly, ependymal cell polarity defects were first observed in c

221 ency impairs the SVZ-NSC pool, neurogenesis, ependymal cell polarity, and cerebrospinal fluid flow, l

222 cord stem cell potential resides within the ependymal cell population and declines with age.

223 Hypothalamic tanycytes, a radial glial-like ependymal cell population that expresses numerous genes

224 Spinal cord ependymal cells, previously reported to be multipotent,

225 for several weeks, we found no evidence that ependymal cells proliferate.

226 with one or two cilia, but not multiciliated ependymal cells, proliferate and give rise to new ependy

227 his in-depth characterization of spinal cord ependymal cells provides insight into their biology and

228 he SCO-spondin/Wnt5a/Frizzled-2/Cx43 axis in ependymal cells regulates ciliary beating, a cyclic and

229 ental potential of the postnatal spinal cord ependymal cells remain to be defined.

230 lational polarity) in radial progenitors and ependymal cells remain unclear.

231 Here we show that SVZ astrocytes, and not ependymal cells, remain labeled with proliferation marke

232 owever, the proliferative capacity of mature ependymal cells remains controversial, and the developme

233 expressing adult neural stem cells, CD133(+) ependymal cells represent an additional-perhaps more qui

234 for ciliogenesis in Chlamydomonas and murine ependymal cells, respectively.

235 e (ATP-gamma-S) to acutely isolated ciliated ependymal cells resulted in CBF responses similar to tho

236 ity and promoted aberrant growth of aqueduct ependymal cells, resulting in aqueduct stenosis and the

237 Multiciliated ependymal cells show morphological characteristics simil

238 ic genes while also inhibiting expression of ependymal cell-specific genes.

239 Viral expression of p11 in ependymal cells specifically rescues the pathophysiologi

240 imum principal tissue strain and the largest ependymal cell stretch consistently localize in the ante

241 The postmitotic nature of ependymal cells strongly suggests that these cells do no

242 eneity and identify across the entire CNS an ependymal cell subset wherein resides damage-responsive

243 DNGR-1 lineage tracing in mice identifies an ependymal cell subset, wherein resides latent regenerati

244 nd aged mice, identifying not only all known ependymal cell subtypes but also immature as well as mat

245 ern of expression to markers of hypothalamic ependymal cells, such as Rarres2 (retinoic acid receptor

246 topic expression of genes specific to cuboid ependymal cells, such as Rarres2.

247 antigenic and morphologic characteristics of ependymal cells, suggesting a novel form of SVZ-supporte

248 nucleus of the solitary tract (NTS) and the ependymal cells surrounding the 4th ventricle (4Vep).

249 Finally, many ependymal cells surrounding the central canal were inten

250 epithelium of the choroid plexus and in the ependymal cells surrounding the lateral ventricles.

251 expression of thyroid hormone deiodinases in ependymal cells (tanycytes) of the fetal hypothalamus, a

252 ighly concentrated in a group of specialized ependymal cells, tanycytes, lining the wall and floor of

253 Tanycytes are highly specialized ependymal cells that form a blood-cerebrospinal fluid (C

254 HSD2 immunoreactivity was also found in the ependymal cells that form the subcommissural organ.

255 Tanycytes are highly specialized ependymal cells that line the bottom and the lateral wal

256 em cell niche is comprised of multi-ciliated ependymal cells that line the brain ventricular system a

257 ymal cells, proliferate and give rise to new ependymal cells that presumably remain in the macaque ce

258 strocytes in the glial scar are generated by ependymal cells, the neural stem cells in the spinal cor

259 On the ependymal cells, these defects lead to disorganized beat

260 l bodies and controls the planar polarity of ependymal cells through regulating the organization of m

261 .1 progenitor gene is constantly detected in ependymal cells throughout chick and mouse development.

262 n the labeling intensity observed in regular ependymal cells throughout the ventricular system.

263 between cells in both radial progenitors and ependymal cells (tissue polarity).

264 The opposite response of ciliated ependymal cells to 5-HT and ATP provides a novel mechani

265 In addition, loss of SOX9 led ependymal cells to adopt a neuroblast identity.

266 Exposure of ependymal cells to forskolin caused a decrease in CBF.

267 nexins are involved in the early reaction of ependymal cells to injury, representing a potential targ

268 ccess to the CSF through a specialized glial/ependymal cell type, the tanycyte.

269 infant and adult human spinal cord contains ependymal cell types that resemble those present in the

270 rectly test whether radial glia give rise to ependymal cells, we used a Cre-lox recombination strateg

271 Some fourth-ventricle ependymal cells were also labeled.

272 lls lacked NET immunoreactivity, whereas CNS ependymal cells were an unexpected site of labeling.

273 In contrast, ependymal cells were labeled by BrdU administration duri

274 ved in circumventricular organs, and OCT3-ir ependymal cells were observed in the linings of all cere

275 Although, ependymal cells were once suggested to have stem cell ch

276 Tanycytes and ependymal cells were the most FGF1-responsive cell type

277 persists at the base of the motile cilia in ependymal cells, which also exhibit a severe ciliopathy.

278 This resulted in apoptosis of ependymal cells, which constitute the blood-cerebrospina

279 key molecular determinant for depression in ependymal cells, which is significantly decreased in pat

280 ring transcriptomes of spinal cord and brain ependymal cells, which lack stem cell abilities, we iden

281 calization restored by incubation of fro/fro ependymal cells with exogenous C24:1 ceramide, which dir

282 ities, we combined patch-clamp recordings of ependymal cells with immunohistochemistry for various co

283 Here we show that ependymal cells with one or two cilia, but not multicili

284 ventricle resulted in stable transduction of ependymal cells, with approximately 10-fold more positiv

285 tors were localised within the tanycytes and ependymal cells, with higher expression under long (LD)