ライフサイエンスコーパス: epiboly

1 rface during a gastrulation process known as epiboly.

2 alations in the mesendoderm, irrespective of epiboly.

3 e, all of which likely contribute to delayed epiboly.

4 epithelium of the zebrafish gastrula during epiboly.

5 tine and cytidine-5-diphosphocholine) during epiboly.

6 ssion patterns and explains expansion during epiboly.

7 erative factors, including cyclin D1, at 70% epiboly.

8 during Wnt/PCP signalling without affecting epiboly.

9 of morphogenetic movements during zebrafish epiboly.

10 l and temporal movements of BCR cells during epiboly.

11 rrest of development at the beginning of the epiboly.

12 edge of the presumptive neuroectoderm by 70% epiboly.

13 re required for blastocoel roof thinning and epiboly.

14 te in involution as the blastoderm undergoes epiboly.

15 nover within EVL cells during the process of epiboly.

16 r progenitors in the zebrafish embryo at 40% epiboly, a stage prior to the initiation of gastrulation

17 f differentially expressed genes between 75% epiboly and 24 hpf stages.

18 re normally expressed in the germring by 50% epiboly and are induced in the primordium of rhombomere

19 at the one-cell stage resulted in defects at epiboly and C&E.

20 These waves first appeared at about 65% epiboly and continued to arise every 5-10 min up to at l

21 ding or FN fibrillogenesis but perturbs both epiboly and convergence/extension.

22 has largely been interpreted to result from epiboly and convergent-extension movements that drive bo

23 embryo can be attributed to a combination of epiboly and dorsal convergence-extension.

24 ncluding the cell movements of gastrulation, epiboly and dorsal convergence.

25 fish B-ephrins are expressed as early as 30% epiboly and during gastrula stages: in the germ ring, sh

26 ed by the competition between extraembryonic epiboly and embryonic myosin-driven contraction-which pe

27 lly rescued ethanol-induced gene expression, epiboly and gastrulation defects.

28 re-derived surface epithelium that undergoes epiboly and in the large vegetal blastomeres that gradua

29 e that Yes kinase plays an important role in epiboly and indicate that Yes kinase participates in sig

30 by deregulating the epithelial movements of epiboly and involution.

31 ession begins immediately after the onset of epiboly and is most active before appearance of the germ

32 Both epiboly and microtubule defects were partially restored

33 embrane impermeant fluorescent probes to pre-epiboly and mid-epiboly embryos.

34 blastomeres to respond to signals directing epiboly and not on the signals themselves.

35 e embryos are smaller and exhibit defects in epiboly and patterning of axial and prechordal mesoderm.

36 nalling was established as being between 60% epiboly and tailbud stages using the Fgf receptor inhibi

37 st detected in the animal hemispheres at mid-epiboly and then the vegetal hemispheres by the end of g

38 towards the vegetal pole in the movements of epiboly and towards the dorsal midline in convergent mov

39 omethylation within the target loci prior to epiboly, and ciglitazone altered TDCIPP-induced effects

40 nt predictions of cell rearrangements during epiboly, and here was used to predict successfully the l

41 morpholino oligonucleotide caused defects in epiboly, and led to reduced cell adhesion as shown by ce

42 1 kinases reduces a specific cell migration, epiboly, and results in the reduction of goosecoid expre

43 lization, then increase progressively during epiboly, and was maintained at high levels throughout ga

44 ebrate morphogenesis, we have focused on the epiboly arrest mutant half baked (hab), which segregates

45 ing a putative dominant negative Irf6 caused epiboly arrest, loss of gene expression characteristic o

46 own results in impaired cell movement during epiboly as well as in subsequent stages.

47 al cells have been shown to rearrange during epiboly, as they spread to cover the large yolk cell.

48 as a thickening in the germ ring of the mid-epiboly blastoderm.

49 ptosis in morphants were normal prior to 90% epiboly, but were elevated after 10 h post-fertilization

50 s, affect the major morphogenetic processes, epiboly, convergence and extension, and tail morphogenes

51 ential mechanisms involved in TDCIPP-induced epiboly defects and (2) determine whether coexposure to

52 hosphate flame retardant (OPFR) that induces epiboly defects during zebrafish embryogenesis, leading

53 lome in both the induction and mitigation of epiboly defects induced by TDCIPP.

54 lsr activity in zebrafish embryos results in epiboly defects that appear to be independent of the req

55 Although TDCIPP-induced epiboly defects were not associated with adverse impacts

56 Bckdk mRNA knockdown caused epiboly defects, ZGA deregulation, H3K27ac reduction and

57 yos to TPHP partially blocked TDCIPP-induced epiboly defects.

58 y detected with TDCIPP-enhances or mitigates epiboly defects.

59 cohesion that primarily leads to the in vivo epiboly defects.

60 pha agonist) nearly abolished TDCIPP-induced epiboly defects.

61 velopmental phenotypes, including a delay in epiboly, depleted S1P levels, elevated levels of sphingo

62 ailed to migrate toward the vegetal pole and epiboly did not occur, a phenotype similar but distinct

63 erienced by the rearranging EVL cells, post- epiboly embryos, whose EVL cells no longer rearrange, we

64 nt fluorescent probes to pre-epiboly and mid-epiboly embryos.

65 acquired regional identity as a group at 80% epiboly even before making vertical contact with axial m

66 the embryonic midline and the micromere cap, epiboly fails, and the HRO-NOS knockdown embryos die.

67 Apart from disrupting epiboly, FoxH1 MO treatment disrupts convergence and int

68 In situ analyses show that during late epiboly hab is expressed in a radial gradient in the non

69 In contrast, when transplanted at 80% epiboly, hindbrain cells retain their neural fate and ex

70 cs during morphogenetic processes that drive epiboly in early Danio rerio (zebrafish) development.

71 Here we describe cellular events during epiboly in normal embryos and in embryos perturbed by ei

72 w that during extraembryonic tissue (serosa) epiboly in the insect Tribolium castaneum, the non-proli

73 impaired the early morphogenetic movement of epiboly in zebrafish embryos and caused microtubule defe

74 studies indicate that Galpha(12/13) regulate epiboly, in part by associating with the cytoplasmic ter

75 l positions of myocardial progenitors at 40% epiboly indicate that signals residing at the embryonic

76 a YSL-driven zygotic mechanism essential for epiboly initiation and reveals a Ca(2+) channel-independ

77 deficient zebrafish embryos, impaired in the epiboly, internalization, convergence and extension gast

78 directional movements of cells that include epiboly, involution, and convergence and extension (C&E)

79 Epiboly is restored by coinjection of human beta4 cRNA o

80 l membrane turnover in the EVL cells of post-epiboly killifish embryos is accelerated at cell-cell co

81 hyperactivation and progress faster through epiboly, leading to tailbud-stage embryos that have a na

82 eting translation of foxH1 disrupt embryonic epiboly movements during gastrulation and cause death on

83 Epiboly movements expand and thin the nascent germ layer

84 ell layer, which are both known mediators of epiboly movements.

85 Beginning at stage 9, epiboly of the animal cap moves tissue into the dorsal b

86 The epiboly of the Caenorhabditis elegans hypodermis involve

87 the contractile actomyosin ring coordinates epiboly on both the organismal and cellular scales.

88 e that Fyn kinase plays an important role in epiboly, possibly through its effects in calcium signali

89 hrough oriented cell division and to promote epiboly, possibly through maintenance of tissue-surface

90 clude incomplete dorsal convergence, delayed epiboly progression and an early lysis phenotype during

91 this developmental solution utilized during epiboly resembles the mechanism of wound healing, we pro

92 Loss of Nsdhl function likewise impaired epiboly, similar to MondoA loss of function.

93 We show that during the early stages of epiboly, spindles in the epithelium display dynamic beha

94 Epiboly spreads and thins the blastoderm over the yolk c

95 ar markers reveal that the axial mesoderm of epiboly stage embryos is abnormally widened in beta4GalT

96 gradient is established between 30% and 40% epiboly stages and that it is preceded by graded mRNA ex

97 e epithelial morphogenetic events, including epiboly, that also employ an underlying substrate.

98 On completion of epiboly, the dorsal locus was incorporated into the deve

99 zebrafish beta4 protein blocks initiation of epiboly, the first morphogenetic movement of teleost emb

100 At approximately 90% epiboly, the forerunner cell cluster becomes overlapped

101 as "forerunner cells." Between 60%- and 80%-epiboly, the forerunner cells coalesce into a coherent c

102 long-range intercellular coordination during epiboly, the process in which the blastoderm spreads ove

103 Epiboly, the spreading of the blastoderm over the large

104 Using amphibian epiboly, the thinning and spreading of the animal hemisp

105 ents of convergence and extension as well as epiboly through the G-protein-coupled PGE(2) receptor (E

106 in vivo evidence that Galpha(12/13) regulate epiboly through two distinct mechanisms: limiting E-cadh

107 o image the positions of all nuclei from mid-epiboly to early segmentation by digital sheet light mic

108 During epiboly, using an asymmetric variant of radial intercala

109 over, this turnover rate is increased during epiboly, when the cells are actively rearranging.

110 ased deep cell adhesion and fail to initiate epiboly, which can be rescued by re-expression of 2-OST

111 l-zygotic mutants of mondoa showed perturbed epiboly with low penetrance and compensatory changes in