ライフサイエンスコーパス: epidermis

1 e only dendritic cell (DC) population of the epidermis.

2 igh levels throughout the lesional psoriatic epidermis.

3 tal lineage ground cells of Arabidopsis leaf epidermis.

4 transit time and altered differentiation in epidermis.

5 nflammatory and immunogenic responses in the epidermis.

6 ng non-centrosomal microtubule arrays in the epidermis.

7 keratinocytes within the basal layer of the epidermis.

8 d of the outer periderm and underlying basal epidermis.

9 ring cell differentiation, including in skin epidermis.

10 uring pattern formation in the M. polymorpha epidermis.

11 structural support in basal keratinocytes of epidermis.

12 cinogens in several human tissues, including epidermis.

13 scence showed the lack of plakoglobin in the epidermis.

14 chanics, homeostasis and barrier function in epidermis.

15 , suppress beta-catenin levels in the larval epidermis.

16 he cell-type pattern in the Arabidopsis root epidermis.

17 ogenitors, neural crest, sensory placode and epidermis.

18 vator, colocalized with pro-IL-1alpha in the epidermis.

19 tensions that exclude stomata from the local epidermis.

20 CaSR expression and a surge of Ca(2+)(i) in epidermis.

21 numbers of neutrophils infiltrating into the epidermis.

22 accumulation of CD103(-) CD8 T cells in the epidermis.

23 sed the quantity of antigen delivered to the epidermis.

24 mor suppressor in gastrointestinal tract and epidermis.

25 shown to partially co-localize in the upper epidermis.

26 scence marker, p16Ink4a, in N-WASP-deficient epidermis.

27 ike seam cells in the Caenorhabditis elegans epidermis.

28 d perpendicular divisions and hyperthickened epidermis.

29 pore volume fraction immediately next to the epidermis.

30 bial protein abundantly produced in the skin epidermis.

31 ryngeal progenitors between the endoderm and epidermis.

32 nd and receptor expression in cultured human epidermis.

33 nt of cell-to-cell adhesion in the seed coat epidermis.

34 ration-competent tadpoles, forming the wound epidermis.

35 al organization of the mouse interfollicular epidermis.

36 traepidermal sensory innervation of adjacent epidermis.

37 proliferation in neonatal and wounded adult epidermis.

38 control in the formation of an intact human epidermis.

39 atin filament network in the differentiating epidermis.

40 d maintenance of the barrier function of the epidermis.

41 known about homeostatic mechanisms in the TM epidermis.

42 is highly expressed in the developing murine epidermis.

43 opment, homeostasis, and regeneration of the epidermis.

44 upregulation and their migration out of the epidermis.

45 in healthy and diseased reconstructed human epidermis.

46 ue for their selective migration towards the epidermis.

47 curring hyperproliferation in neonatal mouse epidermis.

48 differentiate to repopulate the depigmented epidermis.

49 ndary that reduces water loss from the plant epidermis.

50 and CAV-1-containing rafts only in the upper epidermis.

51 another planar tissue, the Arabidopsis leaf epidermis [5], polarized, asymmetric divisions of stomat

52 The epidermis, a multilayered epithelium, surrounds and prot

53 an keratinocytes, the major cell type in the epidermis, a tissue that undergoes extensive necrosis at

54 in recovering rapidly within 1-2 days in the epidermis after application.

55 pithelial autografts (CEAs) regenerate human epidermis after transplantation, a curative therapy for

56 ions of stress, fever and UV exposure of the epidermis; all known triggers of clinical HSV reactivati

57 expression was predominantly located in the epidermis, although also evident in the papillary dermis

58 transgenic expression caused alterations in epidermis, aminergic, sensory, and motor neurons.

59 sis cotyledons, we reveal a range within the epidermis and across the cell layers in which these pept

60 patial coordination of stomatal pores in the epidermis and airspaces in the underlying mesophyll tiss

61 he expansion and function of the early wound epidermis and an anti-inflammatory cytokine to resolve e

62 ips, is attached to the anteriorly migrating epidermis and carried to the sensory depression, extrudi

63 FLOT-1-containing lipid rafts throughout the epidermis and CAV-1-containing rafts only in the upper e

64 stem cells maintain homeostasis of the skin epidermis and contribute to its regeneration throughout

65 eous nerves extend throughout the dermis and epidermis and control both the functional and reparative

66 t UV-B light perception occurs mainly in the epidermis and cortex, but deeper tissues such as endoder

67 ively proliferating cells of mouse and human epidermis and cSCC, and downregulated during terminal di

68 Host defense of the epidermis and dermis involves the interplay of many cell

69 t may penetrate through the barrier into the epidermis and dermis of the skin.

70 ells, the predominant gammadelta cell in the epidermis and dermis.

71 of laser-induced micro-vacuolization in the epidermis and dermis.

72 rcade cell epithelium is generated after the epidermis and digestive tract epithelia have matured, en

73 adherin is dispensable to maintain LC in the epidermis and does not regulate LC maturation, migration

74 In the epidermis and during organ elongation ERf activity is re

75 distributions in selected areas of the root epidermis and endodermis.

76 mechanism through which ROCs form the wound epidermis and ensure successful regeneration.

77 cell heterogeneity of human interfollicular epidermis and find four spatially distinct stem cell pop

78 whole plant with the turgor pressure of the epidermis and guard cells, which ultimately determine st

79 We then discuss the epidermis and hair follicle, to provide a non-skeletal e

80 Conversely, the basal layer of the epidermis and hair follicles expressed p120-1 with reduc

81 In SOC, VZV infected the epidermis and HCMV infected the dermis.

82 BK), a regulator of the cell cycle, in mouse epidermis and human epidermal keratinocytes (HEKs).

83 Melanoma grows in the epidermis and invades the dermis before metastasizing.

84 that HDAC3 is expressed broadly in embryonic epidermis and is required for its orderly stepwise strat

85 erm-derived appendages and in palmar/plantar epidermis and is robustly induced when the epidermis exp

86 The skin epidermis and its appendages are subjected to daily assa

87 r Tp63, a master gene for the development of epidermis and its appendages, can respond to skin morpho

88 xtensive axonal branching in the superficial epidermis and large receptive fields.

89 es in their abundance in guard cell-enriched epidermis and mesophyll cells from leaves of K. fedtsche

90 rted and tissue-specific localization in the epidermis and mesophyll of isozymes implicated in starch

91 oth intracellular infection initiated in the epidermis and nodule organogenesis initiated in inner ro

92 interrupted long-term in vivo imaging of the epidermis and other larval organs, including gut, imagin

93 rangements of altered gene expression in the epidermis and prominent clustering of the adjacent derma

94 IRF6 function to ensure the integrity of the epidermis and provide mechanistic insights into why deve

95 in multiple genes, including NOTCH1-3 in the epidermis and SCCIS and oncogenic TP53 mutations in SCCI

96 The data from DNA and RNA sequencing of epidermis and SCCIS provide insights regarding SCCIS for

97 high molecular-weight proteins in shell and epidermis and subsequent loss of degradation products, d

98 In adult skin epidermis and the epithelium lining the esophagus cells

99 hairs are single-cell extensions of the root epidermis and the primary organs for water uptake and nu

100 the lipids of the outer layers of mammalian epidermis and their contribution to barrier formation ha

101 ue and possibly other major tissues, namely, epidermis and tracheal matrix.IMPORTANCE Ascoviruses are

102 ailer cells that migrate between the ventral epidermis and trunk endoderm.

103 represent condensed remains of the cornified epidermis and, likely also, deeper anatomical features,

104 MP7 in normal (NT), tumour (T), hyperplastic epidermis and/or squamous papilloma (Hyp/Pap), poorly-di

105 e elucidate the functions of the early wound epidermis, and further reveal midkine (mk) as a dual reg

106 dihydroxypregnalumisterol in human serum and epidermis, and the porcine adrenal gland.

107 tions between the conformable device and the epidermis; and three-dimensional digital image correlati

108 en new T cell clones were recruited into the epidermis, antigen-specific Trm cells were more efficien

109 Here, we have used the epidermis as a model system to elucidate the cellular ef

110 Using the murine epidermis as a model system, we found that epidermal Tsc

111 Here, using the epidermis as an experimental model with the RNA sequenci

112 llowed bystander Trm cells to persist in the epidermis as efficiently as antigen-specific Trm cells i

113 f LC with fewer and stunted dendrites in the epidermis as well as a decreased number of LC in skin-dr

114 scriptome profiling of K14CreERT;DLX3(fl/fl) epidermis at 3 days identified activated STAT3 as a tran

115 low cell division in mouse esophagus and the epidermis at multiple body sites.

116 and DLG-1 function redundantly in rosette-to-epidermis attachment.

117 tion, particularly under conditions when the epidermis becomes "activated" (hyperproliferative), rema

118 revealed the presence of PGA-FLUO within the epidermis, but a minimal presence in the dermis, thereby

119 not due to defective Vangl2 function in the epidermis, but to changes in cell geometry and packing t

120 However, they did not bind human or mouse epidermis by indirect immunofluorescence.

121 During leaf development, pores in the epidermis called stomata are spaced at least one cell ap

122 In mice, we show that the epidermis can be selectively removed without scarring, w

123 which the consequences of stretching on skin epidermis can be studied at single-cell resolution.

124 The retention of therapeutics within the epidermis can safely treat skin inflammation, scaling, a

125 Although adult epidermis can suppress the expansion of individual mutan

126 (Triticum turgidum), thin sections of native epidermis cells from sorghum (Sorghum bicolor) comprisin

127 embryo and traverse the dermis to reach the epidermis, colonising the skin and eventually homing wit

128 The outer layer of the epidermis composes the skin barrier, a sophisticated fil

129 The Arabidopsis (Arabidopsis thaliana) root epidermis consists of a position-dependent pattern of ro

130 oughout the rice root, including root hairs, epidermis, cortex and stele, and to the leaf vasculature

131 e, whereas concentrations were equivalent in epidermis, cortex, and endodermis within each zone.

132 lysis to identify gene networks activated in epidermis, cortex, and pericycle cells of Arabidopsis (A

133 The integrity of the mammalian epidermis depends on a balance of proliferation and diff

134 Epidermis-derived interleukin (IL)-33 up-regulation and

135 y provides a molecular framework linking the epidermis-derived signal to the stem cell homeostasis in

136 Mice overexpressing TC-PTP in the epidermis developed significantly reduced numbers of tum

137 but its sibling p63 is a master regulator of epidermis development and a key oncogenic driver in squa

138 nificant downregulation of genes involved in epidermis development, keratinocyte differentiation, and

139 nreported susceptibility loci located in the epidermis differentiation complex region.

140 PRANCR-deficient epidermis displayed impaired stratification with reduced

141 anisms that influence clonal dynamics in the epidermis during development and homeostasis, respective

142 l adhesion activates lysosomes in C. elegans epidermis during developmental remodeling of the cuticle

143 ROCs are present in the epidermis during normal tail development and specificall

144 in maintaining intercellular cohesion of the epidermis during photothermal therapy.

145 is known about the roles of the early wound epidermis during the initiation of regeneration and the

146 nerating stump tissues, as well as the wound epidermis, during early axolotl limb regeneration.

147 Within the epidermis, each nerve begins ramifying repeatedly, but t

148 Langerhans cells (LCs) in the psoriatic epidermis engage with keratinocytes (KCs) in tight physi

149 ding an essential subunit of mTORC2 in mouse epidermis (epidermis-specific homozygous Rictor deletion

150 In human keratinocytes and epidermis equivalents, Lawsone exposure enhances the pro

151 We show that both the periderm and the basal epidermis exhibit polarised distribution of adherens jun

152 The Arabidopsis (Arabidopsis thaliana) root epidermis exhibits a position-dependent pattern of root-

153 dynamics taking place during postnatal skin epidermis expansion.

154 r epidermis and is robustly induced when the epidermis experiences chemical, mechanical or environmen

155 terations are present in reconstructed human epidermis exposed to coarse air PM.

156 CRISPR interference (CRISPRi) screen on 2263 epidermis-expressed lncRNAs and identified nine novel ca

157 The human epidermis expresses SR-As SCARA3 and, to a lesser extent

158 st-like skin organoid composed of stratified epidermis, fat-rich dermis and pigmented hair follicles

159 for recruitment of CD8(+) T(RM) cells to the epidermis following allergen exposure.

160 ing for the characterization of newly formed epidermis, following an initial acute wound for the firs

161 that the persistence of the allergen in the epidermis for long periods of time was responsible for b

162 Those Trm cells remained in the epidermis for several weeks and mediated the eczema exac

163 ential increases self-renewal, migration and epidermis formation.

164 ound that in digit separation, the overlying epidermis forms a migrating interdigital epithelial tong

165 produce IFN-gamma and IL-17 were enriched in epidermis from NLP, whereas dermal tissue responses and

166 psoriasiform tissue responses accumulate in epidermis from NLP.

167 rovide fundamental insights into early wound epidermis function, development, and the initiation of l

168 al polarity is established in the developing epidermis has remained poorly understood.

169 5), a type I keratin, which pairs with K5 in epidermis, has been used extensively as a biomarker for

170 determine the distribution of stomata in the epidermis have been studied extensively, but how this re

171 To sustain the proliferative capacity of the epidermis, HNRNPK is necessary for RNA Polymerase II bin

172 fects in architecture of the interfollicular epidermis (IFE) and delayed hair follicle growth.

173 The interfollicular epidermis (IFE) forms a water-tight barrier that is ofte

174 However, the barrier function of the epidermis impedes effective permeation of siRNA into the

175 lying hyperproliferation of the palmoplantar epidermis in both physiological and disease states, and

176 n mice, Klk7 expression was localized to the epidermis in both steady state and inflammation.

177 ramedullary neurons originating from ventral epidermis in cephalochordates (and presumably in ancestr

178 In particular, the barrier-defective epidermis in patients with AD with loss-of-function fila

179 have performed a detailed screen of the leaf epidermis in two generations of the well-established Sol

180 rved in vitro were also present in the human epidermis, in situ correlative light electron microscopy

181 challenges that promote tumorigenesis in the epidermis, including aging, injury, and a secondary muta

182 ession of transgenic p16(INK4a) in the mouse epidermis induces hyperplasia and dysplasia, involving h

183 us thickening of sclerenchyma cells near the epidermis, inhibiting M. oryzae penetration at the early

184 in hyperproliferation of the basal layer of epidermis, inhibition of markers of terminal differentia

185 a T cells provide immune surveillance of the epidermis, intestinal, and oral mucosa, whereas the pres

186 4-Dsg2/Ptc1(+/lacZ) mice) or the superficial epidermis (Inv-Dsg2/Ptc1(+/lacZ) mice) resulted in incre

187 ce hole made by the needleless device in the epidermis is 0.17 mm rather than 0.39 mm of a normal nee

188 The mammalian epidermis is a highly organized tissue structure that is

189 The palmoplantar epidermis is a specialized area of the skin that undergo

190 Migration of LCs from the epidermis is accompanied by upregulation of IRF4, antige

191 Here, we found that SCF expression in the epidermis is decreased in mouse models of delayed wound

192 ve-cell imaging, we show that homeostatic TM epidermis is distinct from other epidermal sites and has

193 le the makeup of healthy stratum corneum and epidermis is generally understood, the mobilization of m

194 iptome of in vivo palmoplantar (i.e., volar) epidermis is globally unique, including Keratin 9 (KRT9)

195 , these results show that specialized nipple epidermis is maintained by estrogen-induced repression o

196 aberrant high BMP signaling in the lesional epidermis is mediated by a KC intrinsic mechanism, as su

197 Formation of a specialized wound epidermis is required to initiate salamander limb regene

198 How stem cells give rise to epidermis is unclear despite the crucial role the epider

199 The outer layer, the epidermis, is composed predominantly of keratinocytes, w

200 tion approach using a minimally invasive and epidermis-limited skin preparation based on laser-induce

201 roarray and RNA sequence of S1pr2(-/-) mouse epidermis linked the barrier dysfunction with a decrease

202 In stratified epidermis, meanwhile, softening and enhanced remodelling

203 t destroy the pigment-producing cells of the epidermis, melanocytes, leading to areas of depigmentati

204 xpressed in all aerial tissues including the epidermis, mesophyll, and vascular bundle, its tissue-sp

205 -cell transcriptomes were obtained from root epidermis mutants, enabling a comparative analysis of ge

206 eceptor in AD-related cytokine secretion and epidermis-nerve communication.

207 The expression of 11beta-HSD1 in the epidermis of AD lesions was higher than that in the epid

208 ic epidermal cells (IDEC) are located in the epidermis of AD patients and contribute to the inflammat

209 ages were significantly more abundant in the epidermis of AGW specimens than control specimens.

210 is of AD lesions was higher than that in the epidermis of healthy controls.

211 found increased expression of S100A12 in the epidermis of human hypertrophic and keloid scar.

212 toside-binding lectin, is upregulated in the epidermis of human psoriatic skin lesions as well as in

213 , such as the interdigitated patterns in the epidermis of many eudicotyledon leaves, is much less wel

214 he cuticle, the outermost layer covering the epidermis of most aerial organs of land plants, can have

215 polysaccharides, present in the mucilaginous epidermis of plant seeds, as inexpensive drag reducers i

216 The aerial epidermis of plants plays a major role in environmental

217 Stomata are adjustable pores in the aerial epidermis of plants.

218 ession of glucocorticoid biosynthesis in the epidermis of psoriatic skin leading to localized deficie

219 defects of motile cilia were observed in the epidermis of Smed-TTBK-d(RNAi) by phase contrast, immuno

220 ls develop among flat epidermal cells in the epidermis of the early-diverging land plant Marchantia p

221 crest must traverse the dermis to reach the epidermis of the skin and hair follicles.

222 knock-in mouse line, we show that the upper epidermis of the skin is exclusively innervated by GRP f

223 oot endodermis, the vascular cambium and the epidermis of the stem.

224 -dsRNA nanoparticles in midgut, fat body and epidermis of yellow fever mosquito, Aedes aegypti larvae

225 This double face is evident in the embryonic epidermis of zebrafish loss-of-function mutants in the c

226 of the small nerve fibers that innervate the epidermis, one hypothesis is that erythromelalgia could

227 ng layer precedes the formation of the basal epidermis, our analyses suggest that peridermal polarity

228 In the developing murine epidermis, planar and perpendicular divisions yield symm

229 rmis is unclear despite the crucial role the epidermis plays in barrier and appendage formation.

230 ntraepidermal nerve fibre density [fibres/mm epidermis pre: 4.20 (2.83), post: 5.35 (3.34), P = 0.001

231 family members within the lesional psoriatic epidermis preferentially signal through the canonical BM

232 We found that the epidermis promotes the activation and infiltration of T

233 tivity; that RIPK4 and IRF6 expressed in the epidermis regulate the same biological processes; and th

234 en together, our study demonstrates that the epidermis regulates thermoresponsive growth through the

235 e to hair follicles, sebaceous glands and/or epidermis renewal.

236 tenance of high-turnover tissues such as the epidermis requires a balance between stem cell prolifera

237 Development of the skin epidermis requires tight spatiotemporal control over the

238 hat the selective deletion of NIPP1 in mouse epidermis resulted in epidermal hyperproliferation, a re

239 Talin1-deficient LCs failed to exit the epidermis, resulting in reduced LC migration to skin-dra

240 In vivo imaging of mouse epidermis revealed a patterned distribution of basal cel

241 ane membrane substrate that mimics the plant epidermis, revealing that the penetration of DeltaSho1 s

242 l wound model based on a reconstructed human epidermis (RHE).

243 Three-dimensional reconstructed human epidermis (RHEs) were treated for 2 days with increased

244 s are present in normal-appearing UV-exposed epidermis, sampling normal nonlesional skin requires non

245 FLIM images of ex vivo viable epidermis showed a stable fluorescence lifetime for unpa

246 native power was more than 90% in the viable epidermis skin layer; whereas for BRAF inhibitors, discr

247 Here, we uncover that epidermis specific transcription factors, ARABIDOPSIS TH

248 we generated mice with tamoxifen-inducible, epidermis-specific alpha3 knockout to determine the role

249 ptosis in RIPK1-deficient keratinocytes, and epidermis-specific deletion of MLKL prevents disease, de

250 Previous studies showed that mice with epidermis-specific deletion of the alpha3 integrin subun

251 Here, we show that epidermis-specific expression of PIF4 induces constituti

252 We show that H encodes a novel epidermis-specific glutaredoxin and that the pattern of

253 ential subunit of mTORC2 in mouse epidermis (epidermis-specific homozygous Rictor deletion [Ric(EKO)]

254 ipk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and co

255 previously speculated to be present in mouse epidermis, sphingosine beta-hydroxyceramide and monoacyl

256 In the epidermis, SR1001 treatment blocks MC903-induced express

257 id elongases that contribute to a waterproof epidermis, suggesting that this pathway is conserved thr

258 in autosomal recessive congenital ichthyosis epidermis, suggesting the CLE provides a scaffold for th

259 , we analyzed time-lapse images of the mouse epidermis taken over 1 week during normal tissue turnove

260 reflectance of long wavelengths by the stem epidermis than samples from a subtropical region, with s

261 f differentiation and water transport in the epidermis that could ultimately compromise the structura

262 riggers a mechanotransduction pathway in the epidermis that promotes axis elongation(7).

263 SPACE (stomata patterning autocorrelation on epidermis), that describes probabilistic two-dimensional

264 During wound closure in the embryonic epidermis, the cells around the wound migrate collective

265 cytes are the most abundant cell type in the epidermis, the most superficial layer of skin.

266 dependent on both muscle activity(7) and the epidermis; the tension generated by muscle activity trig

267 (iRHOM2) regulates thickening of the footpad epidermis through its interaction with K16.

268 of inducible self-antigen expression in the epidermis to elucidate the functional role of CD27 on au

269 nsiently divided clusters of Shha-expressing epidermis to escort pObs into similarly split groups.

270 elaminate as single cells from the embryonic epidermis to give rise to the nervous system.

271 Exposure of reconstructed human epidermis to increasing concentrations (2.2, 8.9, and 17

272 rodissection of human SCCIS and the adjacent epidermis to isolate genomic DNA and RNA for next-genera

273 ll aggregation, mechanically compressing the epidermis to rapidly intensify FGF20 expression.

274 ctors form a concentration gradient from the epidermis to the interior cell layers, and this gradient

275 ated changes in NOTCH1 and AhR expression of epidermis treated with coarse air PM.

276 ent of the cellular components of the aerial epidermis-trichomes, stomata, and pavement cells-is stil

277 In Caenorhabditis elegans, wounding the epidermis triggers an immune reaction and a repair respo

278 both displayed long-term persistence in the epidermis under steady-state conditions.

279 ical structure; it makes it pass through the epidermis, until it quickly reaches the subcutaneous lay

280 accine-loaded silk tips are implanted in the epidermis/upper dermis where they release vaccine over a

281 we performed acute deletion of DLX3 in adult epidermis using a tamoxifen-inducible Krt14-cre/ERT syst

282 kinds of sensory cells are scattered in the epidermis, usually singly, but sometimes in pairs, evide

283 eripheral nerves pass from the dermis to the epidermis via small fenestrae in the sub-epidermal colla

284 ized, stratified squamous, psoriasiform-like epidermis was observed.

285 Reconstructed human epidermis was used to test the effects of PPD in vitro.

286 a1/alpha2) in unaffected areas of the viable epidermis was ~2.5-3.0, whereas the ratio at puncture ho

287 Here, using avian epidermis, we find two major strategies regulate beta-ke

288 CD8(+) epidermal T(RM) cells persist in the epidermis, we show that CD8(+) epidermal T(RM) cells hav

289 tory activity of these cells; changes in the epidermis were not significant.

290 However, these unicellular extensions of the epidermis were significantly larger in cv HI10 than in c

291 s to communicate with the basal layer of the epidermis where replicating keratinocytes are located.

292 only mononuclear phagocyte population in the epidermis where they detect pathogens.

293 SOX6 is abnormally expressed throughout the epidermis, where it impairs skin barrier development.

294 its implication in the homeostasis of human epidermis, where three PADs are expressed, namely PAD1,

295 Using the segmented embryonic epidermis whose flanks fuse during Drosophila dorsal clo

296 d a pulse of pSMAD1 at the edge that induced epidermis, whose juxtaposition to central neural fates s

297 le-layered epithelium of the early embryonic epidermis, winner progenitors kill and subsequently clea

298 d with lymphocytes and developed a thickened epidermis with increased expression of the inflammatory

299 key pathways involved in repopulation of the epidermis with melanocytes in vitiligo and in regrowth o

300 and at minimum, penetrate and probe manatee epidermis with their mouthparts.