ライフサイエンスコーパス: epithelial sodium channel

1 ally non-significant upregulation of SCNNA1 (epithelial sodium channel).

2 f epithelial Na(+) transport mediated by the epithelial sodium channel.

3 ity of a nonselective cation channel and the epithelial sodium channel.

4 lectrolyte regulation via proteolysis of the epithelial sodium channel.

5 in kinase SGK1, leading to activation of the epithelial sodium channel.

6 K1, which impacts membrane expression of the epithelial sodium channel.

7 e for the attenuated response is through the epithelial sodium channel.

8 ack the normal tonic inhibition of the renal epithelial sodium channel.

9 t sensitivity through a dysregulation of the epithelial sodium channel.

10 quid secretion is minor and does not involve epithelial sodium channels.

11 ably due to an action on amiloride sensitive epithelial sodium channels.

12 y the regulation by methylation reactions of epithelial sodium channels.

13 ubunits of the mammalian amiloride-sensitive epithelial sodium channels.

14 y and belong to the superfamily of degenerin/epithelial sodium channels.

15 t addition of 10-4 M amiloride (a blocker of epithelial sodium channels) abolished the adrenaline-ind

16 he CCD and indirectly reduces principal cell epithelial sodium channel abundance and function.

17 Here, we discover a degenerin/epithelial sodium channel/acid-sensing ion channel from

18 c glutamate receptors and trimeric degenerin/epithelial sodium channel/acid-sensing ion channels.

19 ion is required for SGK1 phosphorylation and epithelial sodium channel activation.

20 lysis to investigate the effect of PIP(2) on epithelial sodium channel activity in A6 cells.

21 hloride absorption, transepithelial voltage, epithelial sodium channel activity, and pendrin abundanc

22 treated mice reduced chloride absorption and epithelial sodium channel activity, despite principal ce

23 pertension, can be affected by modulation of epithelial sodium channel activity.

24 ation, we examined skin of mice in which the epithelial sodium channel alpha subunit had been deleted

25 The amiloride-sensitive epithelial sodium channel alpha, beta, and gamma subunit

26 s to the regulation of the gene encoding the epithelial sodium channel alpha, ENaCalpha, in renal tub

27 renal expression of the aldosterone-induced epithelial sodium channel alpha-ENaC, greater medullary

28 ta decreased basal and dexamethasone-induced epithelial sodium channel alpha-subunit (alpha ENaC) mRN

29 entical FURIN-cleavable peptide on the human epithelial sodium channel alpha-subunit (ENaC-alpha).

30 kidney exhibited increased expression of the epithelial sodium channel alpha-subunit, largely abolish

31 the alpha-subunit of the amiloride-sensitive epithelial sodium channel (alpha-ENaC) was identified as

32 ary culture express the alpha-subunit of the epithelial sodium channel (alpha-ENaC).

33 The mRNA expression of both human epithelial sodium channel-alpha and -beta increased duri

34 Both human epithelial sodium channel-alpha and -beta were localized

35 decreased the expression and/or activity of epithelial sodium channel-alpha, renal outer medullary p

36 d via regulation of the alpha subunit of the epithelial sodium channel (alphaENaC).

37 This drug is known to interact with the epithelial sodium channel and acid-sensing ion channel p

38 e Cyp4a10-/- mice had a dysfunctional kidney epithelial sodium channel and became normotensive when a

39 for Period 1 in the regulation of the renal epithelial sodium channel and more broadly implicate the

40 showed augmented protein expression of gamma-epithelial sodium channel and NHE3 (sodium-hydrogen anti

41 at culminates with an abnormal regulation of epithelial sodium channel and salt sensitivity in diabet

42 involved in ion transport, specifically the epithelial sodium channel and sodium proton exchangers.

43 distal tubules via activation of the apical epithelial sodium channel and the basolateral Na(+)/K(+)

44 und closure in diabetic animals by targeting epithelial sodium channels and stimulating keratinocyte

45 rations in the gating activity of the kidney epithelial sodium channel, and (c) identify a conceptual

46 e mediated largely through activation of the epithelial sodium channel, and inactivating or activatin

47 nters through apical channels, primarily the epithelial sodium channel, and is pumped into the lung i

48 An epithelial sodium channel antagonist normalized plasma v

49 l activities for the Na(+), K(+)-ATPase, and epithelial sodium channel are markedly increased in the

50 ls contrast with DCT1 cells by expression of epithelial sodium channel B- and y-subunits and much str

51 e chain reaction revealed that expression of epithelial sodium channel beta was reduced in distal col

52 Part of the last exon of the epithelial sodium-channel beta subunit from genomic DNA

53 mice overexpressing the beta-subunit of the epithelial sodium channel (beta-ENaC), a model with feat

54 ve mice received HS containing a long acting epithelial sodium channel blocker (P308); isotonic salin

55 contribution of sodium was minimized by the epithelial sodium channel blocker amiloride.

56 Amiloride, an epithelial sodium channel blocker, suppresses the respon

57 The epithelial sodium-channel blocker amiloride has been sho

58 e have shown that amiloride, an inhibitor of epithelial sodium channels, blocks synthesis of differen

59 transport regulator, interacting with Na(+) (epithelial sodium channel), Cl(-), renal outer medullary

60 nd the 5' flanking region of a member of the epithelial sodium channel complex.

61 Ion channels in the degenerin-epithelial sodium channel (DEG-ENaC) family perform dive

62 tive ion channels belonging to the degenerin/epithelial sodium channel (DEG/ENaC) family activate in

63 NIFICANCE STATEMENT Members of the degenerin/epithelial sodium channel (DEG/ENaC) family are broadly

64 Degenerin/epithelial sodium channel (DEG/ENaC) family members are

65 of the MD neuron subtype-specific degenerin/epithelial sodium channel (DEG/ENaC) family protein Pick

66 odes an ion channel subunit of the degenerin/epithelial sodium channel (DEG/ENaC) family.

67 lex that contains the pore-forming degenerin/epithelial sodium channel (DEG/ENaC) proteins MEC-4 and

68 a proton-gated ion channel of the degenerins/epithelial sodium channel (DEG/ENaC) receptor family is

69 pocket (ppk) gene, which encodes a Degenerin/Epithelial Sodium Channel (DEG/ENaC) subunit, is require

70 ral sensory neurons expressing the Degenerin/Epithelial sodium channel (DEG/ENaC) subunit, Pickpocket

71 , a gene that encodes a Drosophila degenerin/epithelial sodium channel (DEG/ENaC), regulates neuronal

72 Degenerin/epithelial sodium channels (DEG/ENaCs) are luminaries of

73 The protein family of degenerin/epithelial sodium channels (DEG/ENaCs) is composed of di

74 e members of the diverse family of degenerin/epithelial sodium channels (DEG/ENaCs).

75 nels (ASICs) are proton-gated members of the epithelial sodium channel/degenerin (ENaC/DEG) superfami

76 roton-activated receptors that belong to the epithelial sodium channel/degenerin family of ion channe

77 Na(+) channels (ASIC) are new members of the epithelial sodium channel/degenerin gene family.

78 nsitive ion channels (ASICs), members of the epithelial sodium channel/degenerin superfamily, were or

79 ve parallel absorption of sodium through the epithelial sodium channel ENaC and the sodium-driven chl

80 ree subunits (alpha, beta, and gamma) of the epithelial sodium channel ENaC and two subunits of Na(+)

81 To test a proposed role for the epithelial sodium channel ENaC in thiazolidinedione-indu

82 The extracellular domain of the epithelial sodium channel ENaC is exposed to a wide rang

83 s that include yeast carboxypeptidase S, the epithelial sodium channel ENaC, and epidermal growth fac

84 These taste cells express the epithelial sodium channel ENaC, and mediate behavioural

85 receptor-alpha, chloride channel CLCN5, and epithelial sodium channel ENaC, can selectively bind to

86 of several different effectors, such as the epithelial sodium channel ENaC, the protease-activated r

87 (2020) report that the epithelial sodium channel ENaC, which serves as the salt

88 n in epithelial cells is rate-limited by the epithelial sodium channel (ENaC) activity in lung, kidne

89 ng patch clamp techniques, we found that the epithelial sodium channel (ENaC) activity in the apical

90 lacking connexin 30 (Cx30) display increased epithelial sodium channel (ENaC) activity in the distal

91 Conversely, epithelial sodium channel (ENaC) activity was largely pr

92 lular functions, including proliferation and epithelial sodium channel (ENaC) activity.

93 ineralocorticoid receptors (MRs) to increase epithelial sodium channel (ENaC) activity.

94 e cleavage of the extracellular loops of the epithelial sodium channel (ENaC) alpha and gamma subunit

95 Epithelial sodium channel (ENaC) alpha-subunit expressio

96 lies have been considered: these include the epithelial sodium channel (ENaC) and acid-sensing ion ch

97 Na(+) uptake through the apically expressed epithelial sodium channel (ENaC) and basolaterally local

98 unction mutations of the amiloride-sensitive epithelial sodium channel (ENaC) and characterized by ne

99 Epithelial sodium channel (ENaC) and cystic fibrosis tra

100 Cyp2c44(-/-) mice show a hyperactive kidney epithelial sodium channel (ENaC) and reductions in ERK1/

101 in connecting tubule mass and attenuation of epithelial sodium channel (ENaC) and ROMK expression and

102 SGK1 increases membrane expression of the epithelial sodium channel (ENaC) and sodium reabsorption

103 gh Na(+) transport by the apically expressed epithelial sodium channel (ENaC) and the basolaterally e

104 more, dKO mice displayed upregulation of the epithelial sodium channel (ENaC) and the Ca(2+)-activate

105 collecting duct, where activity of both the epithelial sodium channel (ENaC) and the pendrin/Na(+)-d

106 sion is decreased by ER stress, activate the epithelial sodium channel (ENaC) and translocate FoxO3a

107 Amiloride (1), the prototypical epithelial sodium channel (ENaC) blocker, has been admin

108 We examined activation of the human epithelial sodium channel (ENaC) by cleavage.

109 omoted internalization of the alphabetagamma epithelial sodium channel (ENaC) complex from the alveol

110 The amiloride-sensitive epithelial sodium channel (ENaC) complex is made up of a

111 entry is controlled by the regulation of the epithelial sodium channel (ENaC) complex.

112 The epithelial sodium channel (ENaC) constitutes the rate-li

113 sterone-induced increases in apical membrane epithelial sodium channel (ENaC) density and Na transpor

114 erinatal lethality associated with increased epithelial sodium channel (ENaC) expression in lung and

115 ocket1 (PPK1) is a Drosophila subunit of the epithelial sodium channel (ENaC) family displaying limit

116 ntriguingly, eRF3a degraders also diminished epithelial sodium channel (ENaC) function.

117 or AF17 upregulates the transcription of the epithelial sodium channel (ENaC) genes, but whether AF17

118 The epithelial sodium channel (ENaC) has an important role i

119 Inhibitors of the epithelial sodium channel (ENaC) have therapeutic potent

120 ic evidence supports a critical role for the epithelial sodium channel (ENaC) in both clearance of fe

121 Overexpression in the epithelial sodium channel (ENaC) in membrane platelets c

122 The epithelial sodium channel (ENaC) in particular is tightl

123 tensin-converting enzyme; stimulation of the epithelial sodium channel (ENaC) in principal cells; and

124 ce was associated with no suppression of the epithelial sodium channel (ENaC) in response to a high-s

125 tional expression of the amiloride-sensitive epithelial sodium channel (ENaC) in select epithelia is

126 osatrienoic acid (11,12-EET) can inhibit the epithelial sodium channel (ENaC) in the cortical collect

127 The activity of the epithelial sodium channel (ENaC) in the distal nephron i

128 Epithelial sodium channel (ENaC) in the kidneys is criti

129 dies have shown that bile acids regulate the epithelial sodium channel (ENaC) in vitro.

130 Maturation of the epithelial sodium channel (ENaC) involves furin-dependen

131 pathway implicated in ubiquitination of the epithelial sodium channel (ENaC) involves Nedd4-2 regula

132 The epithelial sodium channel (ENaC) is a heteromultimer com

133 The epithelial sodium channel (ENaC) is a heterotrimeric pro

134 Activity of the epithelial sodium channel (ENaC) is a key determinant of

135 The epithelial sodium channel (ENaC) is a member of the ENaC

136 To test the hypothesis that the renal epithelial sodium channel (ENaC) is a target of oxidativ

137 The epithelial sodium channel (ENaC) is activated upon endop

138 Enhanced Na(+) absorption through the epithelial sodium channel (ENaC) is attributed to the fa

139 The epithelial sodium channel (ENaC) is believed to represen

140 The epithelial sodium channel (ENaC) is composed of a single

141 The amiloride-sensitive, epithelial sodium channel (ENaC) is composed of at least

142 The epithelial sodium channel (ENaC) is composed of three ho

143 An epithelial sodium channel (ENaC) is composed of three ho

144 The epithelial sodium channel (ENaC) is composed of three ho

145 The epithelial sodium channel (ENaC) is expressed in the ald

146 ose responses to amiloride indicate that the epithelial sodium channel (ENaC) is involved in the move

147 The activity of the amiloride-sensitive epithelial sodium channel (ENaC) is modulated by F-actin

148 The activity of the epithelial sodium channel (ENaC) is modulated by multipl

149 The epithelial sodium channel (ENaC) is one of the central e

150 The epithelial sodium channel (ENaC) is present in the apica

151 The epithelial sodium channel (ENaC) is regulated by multipl

152 The epithelial sodium channel (ENaC) is responsible for Na+

153 The epithelial sodium channel (ENaC) is the limiting entry p

154 The epithelial sodium channel (ENaC) is the prototype of a n

155 The epithelial sodium channel (ENaC) is ubiquitinated by the

156 sed renal cortical mRNA content of all three epithelial sodium channel (ENaC) isoforms, and total cel

157 The amiloride-sensitive epithelial sodium channel (ENaC) mediates Na(+) reabsorp

158 The epithelial sodium channel (ENaC) mediates Na(+) transpor

159 The epithelial sodium channel (ENaC) of the kidney is necess

160 includes subunits of the amiloride-sensitive epithelial sodium channel (ENaC) of vertebrate colon, lu

161 d DeltaF508-CFTR results in an excess of the epithelial sodium channel (ENaC) on the apical plasma me

162 The epithelial sodium channel (ENaC) participates in the reg

163 The epithelial sodium channel (ENaC) plays a major role in t

164 The epithelial sodium channel (ENaC) plays an important role

165 The epithelial sodium channel (ENaC) plays an important role

166 A common human epithelial sodium channel (ENaC) polymorphism, alphaT663

167 The epithelial sodium channel (ENaC) present in the kidney c

168 A K + load rapidly stimulated epithelial sodium channel (ENaC) processing, plasma memb

169 The renal epithelial sodium channel (ENaC) provides regulated sodi

170 Recent molecular cloning of the epithelial sodium channel (ENaC) provides the opportunit

171 The epithelial sodium channel (ENaC) provides the rate-limit

172 red cell model systems commonly used in lung epithelial sodium channel (ENaC) studies.

173 ls to see how overexpression or silencing of epithelial sodium channel (ENaC) subunits and claudin-8

174 m-1 because of loss-of-function mutations in epithelial sodium channel (ENaC) subunits exhibit meibom

175 ide cotransporter (NCC) and alpha- and gamma-epithelial sodium channel (ENaC) subunits from the disco

176 ila miR-263a downregulates the expression of epithelial sodium channel (ENaC) subunits in enterocytes

177 Proteolytic processing of epithelial sodium channel (ENaC) subunits occurs as chan

178 in reactions, expression of all three cloned epithelial sodium channel (ENaC) subunits was detected i

179 teracted with the carboxyl termini of murine epithelial sodium channel (ENaC) subunits.

180 in AS(-/-) mice, whereas upregulation of the epithelial sodium channel (ENaC) sufficient to increase

181 n channel assembled from subunits of the Deg/epithelial sodium channel (ENaC) superfamily, in the reg

182 hannels from the overarching degenerin (DEG)/epithelial sodium channel (ENaC) superfamily, incorporat

183 h supports the ability of insulin to augment epithelial sodium channel (ENaC) transport.

184 d the hypothesis that co-expression of delta-epithelial sodium channel (ENaC) underlies, at least in

185 demonstrated that (1) ATP inhibits the renal epithelial sodium channel (ENaC) via a phospholipase C-d

186 Proteolytic activation of the epithelial sodium channel (ENaC) was compromised by tran

187 Co-localization of epithelial sodium channel (ENaC) with the plasma membran

188 Here we present evidence that the epithelial sodium channel (ENaC), a heteromeric membrane

189 The epithelial sodium channel (ENaC), a heterotrimeric compl

190 dosterone is to increase the activity of the epithelial sodium channel (ENaC), although ENaC mRNA and

191 modulates the cell surface expression of the epithelial sodium channel (ENaC), an ion channel that is

192 -Cl co-transporter, the alpha-subunit of the epithelial sodium channel (ENaC), and the 70-kD dimer of

193 sodium chloride cotransporter (NCC) and the epithelial sodium channel (ENaC), are regulated is param

194 cause amiloride is a potent inhibitor of the epithelial sodium channel (ENaC), ENaC has been proposed

195 gase NEDD4-2, which negatively regulates the epithelial sodium channel (ENaC), Na(+)/Cl(-) cotranspor

196 d K+ handling in these nephron segments--the epithelial sodium channel (ENaC), paracellular Cl- flux,

197 of the Na(+):Cl(-) cotransporter (NCC), the epithelial sodium channel (ENaC), the renal outer medull

198 y transduction channel for sodium taste, the epithelial sodium channel (ENaC), throughout development

199 ansmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC), two major ion channels

200 recessive PHAI results from mutations in the epithelial sodium channel (ENaC), whereas autosomal domi

201 Regulation of the epithelial sodium channel (ENaC), which regulates fluid

202 we assessed whether the HIF pathway controls epithelial sodium channel (ENaC)-dependent sodium transp

203 Epithelial sodium channel (ENaC)-mediated Na(+) entry pr

204 miRs separately or in combination increased epithelial sodium channel (ENaC)-mediated sodium transpo

205 n clearance by proteolytic activation of the epithelial sodium channel (ENaC).

206 egulates sodium transport by stimulating the epithelial sodium channel (ENaC).

207 d inhibit the open probability (P(o)) of the epithelial sodium channel (ENaC).

208 -sensitive Na-Cl cotransporter (NCC) and the epithelial sodium channel (ENaC).

209 embrane conductance regulator (CFTR) and the epithelial sodium channel (ENaC).

210 ed by excessive Na(+) absorption through the epithelial sodium channel (ENaC).

211 ifferential effects on the expression of the epithelial sodium channel (ENaC).

212 regulate the activity and trafficking of the epithelial sodium channel (ENaC).

213 bsorption is governed by the activity of the epithelial sodium channel (ENaC).

214 o the alpha, beta, and gamma subunits of the epithelial sodium channel (ENaC).

215 dium and water homeostasis via action of the epithelial sodium channel (ENaC).

216 t directly with other channels including the epithelial sodium channel (ENaC).

217 the renal collecting duct by activating the epithelial sodium channel (ENaC).

218 tations in the beta- or gamma-subunit of the epithelial sodium channel (ENaC).

219 (CFTR) combined with hyperactivation of the epithelial sodium channel (ENaC).

220 reabsorption through the amiloride-sensitive epithelial sodium channel (ENaC).

221 olytic activation is a unique feature of the epithelial sodium channel (ENaC).

222 a multiforme express multiple members of the epithelial sodium channel (ENaC)/Degenerin family, chara

223 encoding subunits of the amiloride-sensitive epithelial sodium channel (ENaC; refs 2,3).

224 Epithelial sodium channels (ENaC) are composed of three

225 Epithelial sodium channels (ENaC) are expressed in the a

226 Epithelial sodium channels (ENaC) are regulated by vario

227 Heteromeric alpha,beta,gamma-epithelial sodium channels (ENaC) associated with diseas

228 ses the regulation of the activity of single epithelial sodium channels (ENaC) by cAMP.

229 Epithelial sodium channels (ENaC) have a crucial role in

230 We examined how formaldehyde regulates human epithelial sodium channels (ENaC) in H441 and expressed

231 The amiloride-sensitive epithelial sodium channels (ENaC) mediate Na(+) reabsorp

232 Amiloride-sensitive epithelial sodium channels (ENaC) play an important role

233 One explanation is that alcohol regulates epithelial sodium channels (ENaC) via oxidant signaling

234 fects the conductance of amiloride-sensitive epithelial sodium channels (ENaC) was studied in planar

235 is also thought to increase the activity of epithelial sodium channels (ENaC).

236 bicarbonate transport, with dysregulation of epithelial sodium channels (ENaC).

237 he number (N) and open probability (P(o)) of epithelial sodium channels (ENaC).

238 e along its electrochemical gradient through epithelial sodium channels (ENaC).

239 iated by taste receptor cells expressing the epithelial sodium channel, ENaC, but the cellular substr

240 uct, the 70 kDa form of the y-subunit of the epithelial sodium channel, ENaC, exhibited an increase i

241 only the 70 kDa form of the y-subunit of the epithelial sodium channel, ENaC, exhibited an increase i

242 ical membrane where the amiloride-sensitive, epithelial sodium channel, ENaC, facilitates sodium entr

243 The epithelial sodium channel, ENaC, plays a critical role i

244 opposed by fluid absorption, mainly via the epithelial sodium channel, ENaC.

245 sed in cells transfected with siRNAs against epithelial sodium channel ENaCalpha or ENaCdelta compare

246 etween acid-sensing ion channels (ASICs) and epithelial sodium channel (ENaCs), these channel familie

247 rboxyl termini of beta and gamma subunits of epithelial sodium channels (ENaCs) and causes an increas

248 sodium flux in keratinocytes is mediated by epithelial sodium channels (ENaCs) and causes increased

249 Epithelial sodium channels (ENaCs) are assembled in the

250 Epithelial sodium channels (ENaCs) are composed of three

251 self-inhibition and protease-sensitivity in epithelial sodium channels (ENaCs) are not fully underst

252 pression and function of amiloride-sensitive epithelial sodium channels (ENaCs) have not been elucida

253 Epithelial sodium channels (ENaCs) mediate Na(+) entry a

254 luding hormones and growth factors, modulate epithelial sodium channels (ENaCs), which fine-tune Na(+

255 of extracellular protons on the activity of epithelial sodium channels (ENaCs).

256 a Drosophila homolog of mammalian Degenerin/epithelial sodium channels, encodes an acid-sensing sodi

257 sensing ion channel-3 (ASIC3) is a degenerin/epithelial sodium channel expressed in the peripheral ne

258 pocket 25 (PPK25), a member of the degenerin/epithelial sodium channel family (DEG/ENaC).

259 egenerin channel (of Caenorhabditis elegans)/epithelial sodium channel family of ion channels, is the

260 Here we identify a member of the degenerin/epithelial sodium channel family, PPK28, as an osmosensi

261 ed by lower wet/dry weight ratios, increased epithelial sodium channel gamma expression, and more lym

262 the N-terminal tail (APGEKIKAKIKK) of gamma-epithelial sodium channel (gamma-ENaC) were truncated by

263 tate mRNA levels of the gamma subunit of the epithelial sodium channel (gammaENaC) in rat colon.

264 tissue was dissected and analyzed for gamma-epithelial sodium channel (gammaENaC), sodium-potassium

265 Amiloride (10-4 M), a blocker of epithelial sodium channels, had no additive effect to th

266 The human epithelial sodium channel (hENaC) is a hetero-oligomeric

267 The human epithelial sodium channel (hENaC) mediates Na+ transport

268 ee subunits of the human amiloride sensitive epithelial sodium channel (hENaC): SCNN1B and SCNN1G on

269 uitination and elevated levels of functional epithelial sodium channel in cpk cells.

270 In order to ascertain the role of the epithelial sodium channel in epidermal differentiation,

271 ted receptor-gamma agonist activation of the epithelial sodium channel in the distal collecting duct,

272 tion reaction contributes to the activity of epithelial sodium channels in A6 cells and is directed t

273 ecific subunits of amiloride-sensitive human epithelial sodium channels in relation to differentiatio

274 ons that target low renin physiology such as epithelial sodium channel inhibitors and mineralocortico

275 alt-fed DBH-ET(B);ET(B)(sl/sl) rats when the epithelial sodium channel is blocked with amiloride.

276 The epithelial sodium channel is expressed in epidermis and

277 We also show that the activity of the epithelial sodium channel is not altered in FHHt mice, s

278 Although epithelial sodium channel levels were decreased in corte

279 dinated expression of subunits suggests that epithelial sodium channels may play an important part in

280 units, and are members of the superfamily of epithelial sodium channels, mechanosensitive and FMRF-am

281 These data suggest that the epithelial sodium channel modulates ionic signaling for

282 rome, a rare inherited form of hypertension, epithelial sodium channel mutations appear to cause high

283 ion channel genes belonging to the degenerin/epithelial sodium channel/pickpocket (ppk) family, ppk23

284 Downstream targets of mTORC2 implicated in epithelial sodium channel regulation (SGK1 and Nedd4-2)

285 rminal portion of the beta- and/or gamma-rat epithelial sodium channel (rENaC) subunits block constit

286 rm of hypertension in which mutations of the epithelial sodium channel result in increased renal sodi

287 enes for subunits of the amiloride-sensitive epithelial sodium channel: SCNN1B and SCNN1G on 16p and

288 al colon, whereas colonic H,K-ATPase and the epithelial sodium channel showed massive up-regulation i

289 tions disrupting expression of the Degenerin/Epithelial Sodium Channel subunit, Pickpocket1(PPK1) or

290 Pickpocket genes encode Degenerin/Epithelial Sodium channel subunits (DEG/ENaC).

291 iated with increased expression of all three epithelial sodium channel subunits, rather than just the

292 ICs from the overarching DEG/ENaC (degenerin/epithelial sodium channel) superfamily than previously t

293 Yet zebrafish lack epithelial sodium channels, the primary conduit land ani

294 We used amiloride, a blocker of epithelial sodium channels, to evaluate its pharmacologi

295 adult mice in which the alpha-subunit of the epithelial sodium channel was conditionally deleted in t

296 Whereas the beta subunit of human epithelial sodium channel was induced by elevated concen

297 another substrate, the alpha subunit of the epithelial sodium channel, was Pdi1 independent.

298 alpha and regulatory beta subunits of human epithelial sodium channels were expressed both in cultur

299 ystin-2, TRPC1, and interestingly, the alpha-epithelial sodium channel, were immunodetected in this o

300 es from biochemical studies of the mammalian epithelial sodium channels where glycosylation mutants i