ライフサイエンスコーパス: epithelial stem cell

1 helial populations all develop from a common epithelial stem cell.

2 ovement of Ly6C(+)7/4(+) monocytes closer to epithelial stem cells.

3 iferation and differentiation of pluripotent epithelial stem cells.

4 al to maintain lineage fidelity in glandular epithelial stem cells.

5 sential functions regulating self-renewal of epithelial stem cells.

6 lifying) cells and the maintenance of dental epithelial stem cells.

7 -epithelial cell interactions control dental epithelial stem cells.

8 ntenance and regulatory mechanisms of dental epithelial stem cells.

9 nal, and developmental properties of gastric epithelial stem cells.

10 ng GPCR5 (Lgr5), a marker gene of intestinal epithelial stem cells.

11 basal cells and allows comparison with other epithelial stem cells.

12 hts for the preservation and/or expansion of epithelial stem cells.

13 s for the preservation and/or replication of epithelial stem cells.

14 teraction between this bacterium and gastric epithelial stem cells.

15 sociated with a transient increase of limbal epithelial stem cells.

16 ospheres, a property associated with mammary epithelial stem cells.

17 helia and for the proliferative potential of epithelial stem cells.

18 directly regulating components of the DDR in epithelial stem cells.

19 on, and (4) coincide spatially with putative epithelial stem cells.

20 t express cytokeratin 15 (K15), a marker for epithelial stem cells.

21 n significantly enriched in small intestinal epithelial stem cells.

22 topoietic, mesenchymal, and gastrointestinal epithelial stem cells.

23 The hair follicle bulge possesses putative epithelial stem cells.

24 is initiated by a downgrowth from a layer of epithelial stem cells.

25 the hair follicle bulge and the presence of epithelial stem cells.

26 p63, a gene implicated in the maintenance of epithelial stem cells.

27 sion consistent with transduction of corneal epithelial stem cells.

28 ds originate from multipotent ocular surface epithelial stem cells.

29 d in a reduced proliferative response by the epithelial stem cells.

30 regulator of the DDR machinery in intestinal epithelial stem cells.

31 ining G protein-coupled receptor 5 (LGR5(+)) epithelial stem cells.

32 face" (ALI) cultures derived from intestinal epithelial stem cells.

33 ctal cancer develops from mutated intestinal epithelial stem cells.

34 PGD2 and perturbed proliferation dynamics in epithelial stem cells.

35 cells through the existence of two types of epithelial stem cells: active crypt base columnar cells

36 t (Fzd5(ag)) or Fzd6(ag) stimulated alveolar epithelial stem cell activity and promoted survival in m

37 , Lhx2 operates as an important regulator of epithelial stem cell activity in the skin response to in

38 we found that MAPK and PI3K regulate dental epithelial stem cell activity, transit-amplifying cell p

39 Fzd5 is uniquely required for alveolar epithelial stem cell activity, whereas fibroblasts utili

40 the lung during the peak of type 2 alveolar epithelial stem cell (AEC2) proliferation.

41 in amplification of the presumptive gastric epithelial stem cell and its immediate committed daughte

42 h, derived from both the mutation-sustaining epithelial stem cells and adjacent mesenchymal tissues.

43 w the MAPK and PI3K pathways regulate dental epithelial stem cells and amelogenesis.

44 ies regarding the identification of prostate epithelial stem cells and cell types of origin for prost

45 ave been implicated in normal and neoplastic epithelial stem cells and consider the involvement of th

46 ates all of the cardinal behaviors of airway epithelial stem cells and determines epithelial architec

47 enerated human gastric antral organoids from epithelial stem cells and differentiated epithelial mono

48 es directed toward identification of hepatic epithelial stem cells and does not address the controver

49 between the procreative life-span of mammary epithelial stem cells and mammary cancer risk.

50 ramatic impact on replenishment of cutaneous epithelial stem cells and on ovarian germ cell survival.

51 y occurs normally in E2f1-3 triply-deficient epithelial stem cells and progenitors of the developing

52 The hair follicle is a source of epithelial stem cells and site of origin for several typ

53 t for understanding the molecular control of epithelial stem cells and their niches.

54 ese means we have monitored the behaviour of epithelial stem cells and their progeny during physiolog

55 ve gene expression profile of putative human epithelial stem cells and their progeny that were isolat

56 eted signaling molecules in specifying renal epithelial stem cells and their self-renewal, in driving

57 re, we studied the interplay between gastric epithelial stem cells and their stromal niche under home

58 ginal zone, transit-amplifying cells, limbal epithelial stem cells, and corneal stromal stem cells.

59 e hair follicles are maintained by different epithelial stem cells, and provide evidence that the req

60 from hair follicles, which harbor cutaneous epithelial stem cells, and reconstitution of regressing

61 ever, it is not clear if and to which extent epithelial stem cells are affected in NK.

62 ostatic homeostasis in which mouse prostatic epithelial stem cells are concentrated in the proximal r

63 This study provides evidence that epithelial stem cells are dispensable for normal airway

64 e uniform distribution of LRCs, suggest that epithelial stem cells are distributed uniformly in this

65 Intestinal epithelial stem cells are highly sensitive to differenti

66 Corneal epithelial stem cells are located in the basal layer of

67 It appears that most palpebral conjunctival epithelial stem cells are located near the mucocutaneous

68 ns were present in the adult limbal BM where epithelial stem cells are located.

69 Epithelial stem cells are maintained within niches that

70 he identity and characteristics of quiescent epithelial stem cells are not clear.

71 th the authors' hypothesis that conjunctival epithelial stem cells are primarily located in the forni

72 Epithelial stem cells are specified during development a

73 Epithelial stem cells are targets for driver mutations t

74 Breast epithelial stem cells are thought to be the primary targ

75 bel-retaining cells, a key characteristic of epithelial stem cells, are detected in both limbal and c

76 ere is now strong experimental evidence that epithelial stem cells arrange their sister chromatids at

77 ophages contribute to the activation of skin epithelial stem cells as a novel, additional cue that re

78 inding provides evidence in support of basal epithelial stem cells as one target cell for prostate ca

79 tivating expression of factors that regulate epithelial stem cells as well as receptors for the mamma

80 Wnt signature and accumulation of intestinal epithelial stem cells, as expected.

81 limbal stem cells that may maintain corneal epithelial stem cells at a less differentiated state.

82 LGR5 marks resident adult epithelial stem cells at the gland base in the mouse pyl

83 Understanding epithelial stem cell biology has major clinical implicat

84 Recent advances in epithelial stem cell biology have resulted in the isolat

85 The study of epithelial stem cell biology was aided by the ability to

86 thway that similarly controls normal mammary epithelial stem cell biology.

87 mportant experimental model for the study of epithelial stem cell biology.

88 mucosal healing and evaluation of intestinal epithelial stem cell biomarkers may improve clinical mea

89 y of work has begun to characterize the skin epithelial stem cells, both in tissue culture and in mou

90 n otherwise normal intestinal epithelium and epithelial stem cells but, in the context of activated W

91 e domains protein 1 (LRIG1) marks intestinal epithelial stem cells, but the role of LRIG1 in nonepith

92 lthough functional analysis of hair follicle epithelial stem cells by gene targeting is well establis

93 ng results in loss of Apc mutated intestinal epithelial stem cells by interference with the Wnt signa

94 oliferation and differentiation of cutaneous epithelial stem cells by promoting alpha(v)beta(6) integ

95 link between these two mechanisms in mammary epithelial stem cells by showing that transcriptional ac

96 that the fate and multilineage potential of epithelial stem cells can change depending on whether a

97 Human Corneal epithelial stem cells (CESCs) have been identified to re

98 ested whether pathologic determinants in the epithelial stem cell compartment could be detected at th

99 is required for maintenance of a functional epithelial stem cell compartment in murine hair follicle

100 we demonstrate the engraftment of the airway epithelial stem cell compartment via intra-airway transp

101 ompromising the repopulating capacity of the epithelial stem cell compartment.

102 discuss the mechanical forces involved when epithelial stem cells construct their microenvironment a

103 Here we show that normal mammary epithelial stem cells contain lower concentrations of RO

104 can induce mutations that, if they occur in epithelial stem cells, contribute to malignant transform

105 Our data suggest that epithelial stem cells control basement membrane integrit

106 ivating inductive dermal cells and competent epithelial stem cells creates the opportunity to bioengi

107 aging in conjunction with a live reporter of epithelial stem cell cycle activity and as an instrument

108 stant supply of epithelial cells from dental epithelial stem cell (DESC) niches in the cervical loop

109 Sox2 marks dental epithelial stem cells (DESCs) in both mammals and reptil

110 cal pitch created on silk may affect corneal epithelial stem cell differentiation and alter the expre

111 che signals, often Hedgehog-induced, promote epithelial stem cell differentiation as well as self-ren

112 s and that specific microRNAs regulate tooth epithelial stem cell differentiation.

113 Epithelial stem cells divide asymmetrically, such that o

114 are indispensable for survival and growth of epithelial stem cells during adulthood.

115 ways, BMP and SHH, in regulating the fate of epithelial stem cells during organogenesis.

116 of stromal niche cells to control and adapt epithelial stem cell dynamics constitutes a sophisticate

117 mal enhancers and the parallel activation of epithelial/stem cell enhancers.

118 evidence suggests that healthy hair follicle epithelial stem cells enjoy relative protection from inf

119 Epithelial stem cells (EpSCs) in the hair follicle bulge

120 stem cells (McSCs) intimately interact with epithelial stem cells (EpSCs) in the hair follicle bulge

121 environmental assaults, and is maintained by epithelial stem cells (EpSCs).

122 w that EMT also occurs within the bulge, the epithelial stem cell (eSC) niche of human scalp hair fol

123 In general, this paradigm features epithelial stem cells (ESCs) that are called on to regen

124 n the whole mouse uterus to demonstrate that epithelial stem cells exist in the mouse uterus.

125 que among tumor-associated proteases in that epithelial stem cell expression of the protease suffices

126 ogressive conjunctival cicatrisation, limbal epithelial stem cell failure and corneal blindness.

127 e pulmonary fibrosis is the result of distal epithelial stem cell failure.

128 thelium, yet their ability to directly alter epithelial stem cell fate has not been resolved.

129 antagonize epithelial Yap levels to dictate epithelial stem cell fate.

130 at hDF-EpiSCs might be a promising source of epithelial stem cells for the development of stem cell-b

131 solidify the essential role of K14(+) limbal epithelial stem cells for wound healing and refute the n

132 et al. demonstrate the isolation of putative epithelial stem cells from the hair follicle bulge and A

133 neurotrophic ulcers are associated with poor epithelial stem cell function at the limbus.

134 ggest that adipocyte lineage cells may alter epithelial stem cell function clinically.

135 y transcription factor that is essential for epithelial stem cell function that is often overexpresse

136 at regulates Wnt signaling and impacts adult epithelial stem cell function.

137 lity, the inflammatory microenvironment, and epithelial stem cell functions.

138 prevented while immune system activation and epithelial stem cell genetic damage must be minimized.

139 While epithelial stem cells giving rise to ameloblasts have be

140 No such lineage labeling of epithelial stem cells has been reported in the gastric b

141 Although gastric epithelial stem cells have been localized, little is kno

142 ovel method for the isolation of adult human epithelial stem cells (hEpiSCs) from the epithelial comp

143 and essential task of controlling cutaneous epithelial stem cell homeostasis by balancing TGF-beta-m

144 Intestinal epithelial stem cell identity and location have been the

145 dence that microbiota may control intestinal epithelial stem cell (IESC) proliferation in part throug

146 helium is continuously renewed by intestinal epithelial stem cells (IESCs) positioned at the base of

147 Epithelial stem cells in adult mammalian skin are known

148 By using targeted knockout in olfactory epithelial stem cells in adult mice, we show that lamin

149 ng undergoes constant replacement, driven by epithelial stem cells in crypts of Lieberkuhn.

150 on the competition between mutant and normal epithelial stem cells in crypts(1).

151 The differential fate of epithelial stem cells in mouse molars and incisors is co

152 de a niche supporting transient Sox2+ dental epithelial stem cells in mouse molars.

153 in 6a (K6a) transcripts as enriched in bulge epithelial stem cells in mouse skin.

154 is the mouse incisor, which contains dental epithelial stem cells in structures known as cervical lo

155 The discovery of long-lived epithelial stem cells in the bulge region of the hair fo

156 Epithelial stem cells in the bulge region within the hai

157 he utility of the K15 promoter for targeting epithelial stem cells in the hair follicle bulge and set

158 Putative epithelial stem cells in the hair follicle bulge are tho

159 idney-injury molecule-1, markers of putative epithelial stem cells in the human kidney.

160 Epithelial stem cells in the skin are specified during d

161 pathway is essential for the maintenance of epithelial stem cells in the small intestine.

162 Epithelial stem cells in the stomach are responsible for

163 Hydra aging, we compared the self-renewal of epithelial stem cells in these two strains and found it

164 ctive cellular interactions and the roles of epithelial stem cells in tissue regeneration, and for un

165 and fail to generate HFs when engrafted with epithelial stem cells in vivo.

166 FGF10) into cultured incisors rescued dental epithelial stem cells in Wnt1-Cre; Alk5(fl/fl) mice.

167 ls, hair follicle stem cells, and intestinal epithelial stem cells--in which the roles of Wnt/beta-ca

168 support the notion that all Tp63-expressing epithelial stem cells, independently of their embryonic

169 g IL-1) might preferentially activate limbal epithelial stem cells indirectly by fibroblasts and simu

170 malian cornea contains a population of basal epithelial stem cells involved in cornea homeostasis and

171 The reproductive capacity of the mammary epithelial stem cell is reduced coincident with the numb

172 mal tubule harbors a scattered population of epithelial stem cells is a major unsolved question.

173 The landscape of lung epithelial stem cells is getting more nuanced.

174 Genome integrity in epithelial stem cells is maintained by an evolutionarily

175 Notably, transduction of PAX6 in skin epithelial stem cells is sufficient to convert them to L

176 ecifically in SOX2-positive postnatal dental epithelial stem cells is sufficient to generate odontoma

177 While the plasticity of epithelial stem cells is well characterized, the identit

178 fferentiation of epithelial cells, including epithelial stem cells, is conserved from Drosophila to m

179 Intestinal epithelial stem cells (ISCs) are responsible for intesti

180 mpose epigenetic changes on fetal intestinal epithelial stem cells, leading to long-lasting impacts o

181 Destruction of the limbal epithelial stem cell (LESC) population in the cornea can

182 at this difference is associated with limbal epithelial stem cell (LESC) residence and YAP-dependent

183 r, their roles in normal and diseased limbal epithelial stem cells (LESC) remain unknown.

184 Limbal epithelial stem cells (LESCs), located in the basal laye

185 In adult epithelial stem cell lineages, the precise differentiati

186 alopecia results from irreversible damage to epithelial stem cells located in the bulge region of the

187 ation, proliferation, and differentiation of epithelial stem cells located in the bulge, a specializa

188 Resident adult epithelial stem cells maintain tissue homeostasis by bal

189 stem cells (BCSCs) but not in normal mammary epithelial stem cells, maintains tumorous pluripotency o

190 current integration near genes that regulate epithelial stem cell maintenance (i.e., SOX2, TP63, FGFR

191 MP signaling, in addition to its key role in epithelial stem cell maintenance and progenitor cell dif

192 l-autonomous requirement of CBL and CBL-B in epithelial stem cell maintenance during organ developmen

193 common signaling pathways appear to control epithelial stem cell maintenance, activation, lineage de

194 icles did not affect follicular structure or epithelial stem cell maintenance, and stimulation of ana

195 onstrate that Lgr6, but not Lgr5, acts as an epithelial stem cell marker in SCCs in vivo.

196 Additonally, the epithelial stem cell marker SOX2 was significantly upreg

197 on revealed that p63, a well known mammalian epithelial stem cell marker, was localized strictly to a

198 gene previously considered a specific crypt epithelial stem cell marker.

199 the expression of p63, an important corneal epithelial stem cell marker.

200 m cells present highly positive staining for epithelial stem cell markers in all areas of normal TM t

201 higher expression levels of putative corneal epithelial stem cell markers, ATP-binding cassette famil

202 mitantly exhibit an expansion of the mammary epithelial stem cell (MaSC) enriched basal/myoepithelial

203 gain-of-function mutant expands the mammary epithelial stem cells (MESCs) that give rise to the mamm

204 These isolated hair follicle epithelial stem cells must be combined with 'inductive'

205 The cells that compose the epithelial stem cell niche for skin homeostasis and rege

206 recognized as an important component of the epithelial stem cell niche in the rodent lung.

207 epresent essential components of the corneal epithelial stem cell niche, but, due to difficulties in

208 essed in the labial incisor cervical loop or epithelial stem cell niche, with decreased expression in

209 alisades of Vogt that constitute the corneal epithelial stem cell niche.

210 aling components that make up the intestinal epithelial stem cell niche.

211 ing terminal differentiation to establish an epithelial stem cell niche.

212 roach to identify the location of intraorgan epithelial stem cell niches, in situ and in vivo.

213 signaling gradients intrinsic to intestinal epithelial stem cells, Nikolaev et al.

214 Within the hierarchy of epithelial stem cells, normal progenitor cells may expre

215 gene transfer to genetically mark cutaneous epithelial stem cells of adolescent mice, and have follo

216 pensatory proliferation via ERK signaling in epithelial stem cells of larval zebrafish.

217 Here, we demonstrate that epithelial stem cells of non-skin origin (e.g. that of c

218 This review focuses on the epithelial stem cells of skin, where they come from, whe

219 Epithelial stem cells of small and large intestines (ISC

220 Villous cytotrophoblasts are epithelial stem cells of the early human placenta, able

221 it also impairs the stimulation of cutaneous epithelial stem cells of the proliferative phase.

222 crypts formed from primary human intestinal epithelial stem cells on a 3D shaped hydrogel scaffold r

223 Skin epithelial stem cells operate within a complex signaling

224 It is unknown whether epithelial stem cells or epithelial cancer stem cells ar

225 Intestinal epithelial stem cell organoid cocultures of neonatal and

226 Cytokine stimulation of neonatal intestinal epithelial stem cell organoids suggests a network of syn

227 apping studies have identified two principal epithelial stem cell pools in this tissue.

228 The uterine epithelial stem cell population also supports the regene

229 xpressed in the human holoclone-type corneal epithelial stem cell population and sporadically express

230 (FGFR2b), is crucial for development of the epithelial stem cell population in mouse incisors.

231 mucosa as an important model system to study epithelial stem cell populations and how they respond to

232 uggests these markers may be conserved among epithelial stem cell populations.

233 tains anatomically and functionally distinct epithelial stem cell populations.

234 hway that are known to be markers of several epithelial stem cell populations.

235 h as prostaglandin D(2)-dependent reduced HF epithelial stem cell progenitor generation.

236 Indian hedgehog mutants show reduced epithelial stem cell proliferation and differentiation,

237 ockout animals have reduced adult intestinal epithelial stem cell proliferation at the end of metamor

238 n factor known to be required for intestinal epithelial stem cell proliferation, was increased and mi

239 zed the signaling components responsible for epithelial stem cell proliferation.

240 direct link between the EMT and the gain of epithelial stem cell properties.

241 These uterine epithelial stem cells provide a resident cellular supply

242 as a central intrinsic regulator of mammary epithelial stem cell quiescence and exhaustion and is ne

243 pressor and a key regulator of epidermal and epithelial stem cell quiescence.

244 ir follicle (HF) formation is initiated when epithelial stem cells receive cues from specialized mese

245 apabilities, as well as expressed a panel of epithelial stem cell-related genes, thus conferring stem

246 t from those described by innate "training"; epithelial stem cells remained unaltered.

247 role of a dynamic autophagy flux to maintain epithelial stem cell renewal and prevent aging.

248 Limbal epithelial stem cells repopulate the donor site as early

249 Skin epithelial stem cells represent a ripe target for resear

250 It is widely believed that epithelial stem cells reside in the hair follicle bulge

251 The longstanding concept that corneal epithelial stem cells reside mainly in the limbus is sup

252 to a self-renewing cell, the retinal pigment epithelial stem cell (RPESC) that loses RPE markers, pro

253 , DeltaNp63, is a master regulator of normal epithelial stem cell (SC) maintenance.

254 On ocular surface, corneal epithelial stem cells (SC) reside in limbus between corn

255 begins when communication between quiescent epithelial stem cells (SCs) and underlying mesenchymal d

256 Following tissue damage, epithelial stem cells (SCs) are mobilized to enter the w

257 It is accepted that epithelial stem cells (SCs) located in the hair follicle

258 Follicular epithelial stem cells (SCs), located in the bulge region

259 s secreted by ameloblasts derived from tooth epithelial stem cells (SCs).

260 In normal tissues, rapamycin prevents epithelial stem cell senescence by reducing oxidative st

261 Epithelial stem cells serve critical physiological funct

262 Gastric epithelial stem cells strongly expressed ST6Gal-I, sugge

263 differentiation, keratinocyte proliferation, epithelial stem cell survival, adipocyte biology, and in

264 vo suggests that NGF signaling favors limbal epithelial stem cell survival.

265 f death rather than error-prone repair makes epithelial stem cell systems resistant to short exposure

266 at the basal epithelium contains oligopotent epithelial stem cells that also represent the source of

267 The epithelial stem cells that are the ameloblast progenitor

268 This continuous renewal is fueled by adult epithelial stem cells that give rise to ameloblasts, whi

269 e of the major findings about mammalian skin epithelial stem cells that have emerged in the past five

270 rowth is supported by the division of dental epithelial stem cells that reside in the cervical loop r

271 rmal papilla, the organizing center, and the epithelial stem cells that respond to dermal papilla sig

272 Self-renewing mammary epithelial stem cells that were originated during allome

273 has been shown to affect the maintenance of epithelial stem cells, the differentiation of keratinocy

274 gs suggest that TRAF-4 is a marker of normal epithelial stem cells, the expression of which often cea

275 indicated by the regeneration of intestinal epithelial/stem cells, the regulation of the pro-/anti-i

276 s that exhibit three important attributes of epithelial stem cells: they are slow cycling, possess a

277 of persistent exposure of hyperproliferative epithelial stem cells to an inflammatory microenvironmen

278 e distribution allows these bipotent uterine epithelial stem cells to bidirectionally differentiate t

279 an in vitro system to enrich for intestinal epithelial stem cells to discover that Wnt5a inhibited p

280 can influence the commitment of pluripotent epithelial stem cells to divergent pathways of different

281 een much research on the response of stomach epithelial stem cells to inflammation.

282 chanistically, LBH induces expression of key epithelial stem cell transcription factor DeltaNp63 to p

283 Corneal limbal epithelial stem cell transplantation using cultivated hu

284 nd Lgr5 expression define multiple mammalian epithelial stem cell types.

285 rotects from the loss of proliferative basal epithelial stem cells upon ionizing radiation in vivo, t

286 Prior attempts to isolate epithelial stem cells used methods such as proteolytic t

287 cells (mostly mTECs and possibly some adult epithelial stem cells) was sufficient to cause significa

288 he incisor, which contains the niche for the epithelial stem cells, was either severely reduced or co

289 inactivation of the IL-22 receptor in colon epithelial stem cells, we demonstrate that IL-22 is requ

290 rder to identify reliable markers of corneal epithelial stem cells, we employed an inducible transgen

291 Putative epithelial stem cells were identified in the hair follic

292 Corneal epithelial stem cells were isolated from human limbal sp

293 Limbal epithelial stem cells were isolated, and cellular, immun

294 ne, WAP-TGFbeta1, we discovered that mammary epithelial stem cells were prematurely aged due to ectop

295 of stratified epithelium, which includes the epithelial stem cells, were engineered and crossed with

296 the precise cell fates of these two types of epithelial stem cells, which give rise to functionally d

297 bit limbal basal epithelium contains corneal epithelial stem cells, which have been characterized by

298 Radiation has been postulated to target epithelial stem cells within the crypts of Lieberkuhn to

299 Epithelial stem cells within the human hair follicle are

300 To test whether premature aging of mammary epithelial stem cells would have an impact on susceptibi