ライフサイエンスコーパス: epoxidase

1 r degradation of epoxidases (e.g. zeaxanthin epoxidase).

2 strate, the enzyme is converted to an active epoxidase.

3 rived metabolites that were dependent on the epoxidase.

4 um tricornutum as the candidate diatoxanthin epoxidase.

5 e overexpressed and purified the desired HPP epoxidase.

6 between OsONS1 and both O. spinosa squalene epoxidases.

7 ntaining epoxidases, such as cytochrome P450 epoxidases.

8 yrans can be initiated by post-assembly line epoxidases.

9 Here, we identified zeaxanthin epoxidase 3 (ZEP3) from Phaeodactylum tricornutum as the

10 op codon mutation in Sqle, encoding squalene epoxidase, a rate-limiting enzyme in cholesterol biosynt

11 enzymes, hexokinase 1 (HXK1) and zeaxanthin epoxidase (ABA1), by transcriptional control.

12 maleimide inhibited both the carboxylase and epoxidase activities of the enzyme.

13 The vitamin K epoxidase activities of these mutants were reduced in pa

14 he two-chain carboxylase had carboxylase and epoxidase activities similar to those of one-chain carbo

15 lase, the His to Ala mutants all showed full epoxidase activity but K218A activity was not detectable

16 rbate availability can limit violaxanthin de-epoxidase activity in vivo, leading to a lower NPQ.

17 Epoxidase activity is induced by Phe-Leu-Glu-Glu-Leu (FL

18 galactosyl diacyl glycerol (which enhance de-epoxidase activity) likely enable de-epoxidation.

19 ng the ets1-1 allele have decreased squalene epoxidase activity, while those containing the ets2-1 al

20 (dry2) mutant that shows decreased squalene epoxidase activity.

21 gnificant vitamin K-dependent carboxylase or epoxidase activity.

22 carboxylase activity and vitamin K-dependent epoxidase activity.

23 ning substrate, carboxylase has little or no epoxidase activity.

24 Squalene epoxidase (also known as squalene monooxygenase, EC 1.14

25 ectal cancer cell lines highlighted squalene epoxidase, an oxygen-requiring enzyme in cholesterol bio

26 Using purified epoxidase and (18)O isotopic labeled HPP, the retention

27 asmic reticulum cholesterol-sensors squalene epoxidase and HMG-CoA reductase.

28 Therefore, this protein is indeed a true HPP epoxidase and is termed Ps-HppE.

29 The association of violaxanthin de-epoxidase and monogalactosyldiacyglyceride at pH 5.2 is

30 Violaxanthin de-epoxidase and zeaxanthin epoxidase catalyze the addition

31 Sequence analyses of both violaxanthin de-epoxidase and zeaxanthin epoxidase establish the xanthop

32 ibitors terbinafine (TBF, targeting squalene epoxidase) and itraconazole (ITZ, targeting lanosterol C

33 aryl-coenzyme A (HMG-CoA) synthase, squalene epoxidase, and acyl-CoA:cholesterol acyltransferase (ACA

34 vel metabolites, identification of the 10,11-epoxidase, and full characterization of the mupirocin bi

35 t loss of function of DDB1, DET1, Zeaxanthin Epoxidase, and Ip up-regulates CHRC levels.

36 s-related protein1 (LHCSR1), violaxanthin de-epoxidase, and PSII subunit S, remained stable.

37 he non-heme diiron enzyme benzoyl coenzyme A epoxidase, BoxB.

38 In contrast, the Leptospira ortholog showed epoxidase but not detectable carboxylase activity and di

39 activate de-epoxidases (e.g. violaxanthin de-epoxidase), but in darkness alternative electron transpo

40 ed to provide further insights into the P450 epoxidase catalytic efficiency affected by substrate str

41 Violaxanthin de-epoxidase and zeaxanthin epoxidase catalyze the addition and removal of epoxide g

42 Violaxanthin de-epoxidase catalyzes the de-epoxidation of violaxanthin t

43 ructure of the N-terminally histidine-tagged epoxidase component of this system, NSMOA, determined to

44 Squalene epoxidase converts squalene into oxidosqualene, the prec

45 acid methyltransferase (JHAMT) and the P450 epoxidase CYP15 (EPOX).

46 Processes involving violaxanthin de-epoxidase dampened changes in chlorophyll fluorescence i

47 e components, KEA3 and the diadinoxanthin de-epoxidase, describes most of the feedback loops between

48 as amino levulinate synthase 1 and squalene epoxidase displayed CAR-independent induction by PB.

49 ed in wild-type cells or cells with squalene epoxidase down-regulated.

50 lly leads to the pH changes that activate de-epoxidases (e.g. violaxanthin de-epoxidase), but in dark

51 dation is inactivation and/or degradation of epoxidases (e.g. zeaxanthin epoxidase).

52 e contrary, the overexpression of zeaxanthin epoxidase enables a faster reconversion of zeaxanthin to

53 A P450 epoxidase encoded by c rpE recently identified from the

54 values for the epoxide and a stereospecific epoxidase enzyme has been proposed to account for this d

55 is dependent on the dosage of the zeaxanthin epoxidase enzyme.

56 oth violaxanthin de-epoxidase and zeaxanthin epoxidase establish the xanthophyll cycle enzymes as mem

57 sion is required to regulate violaxanthin de-epoxidase expression and to support photosynthetic activ

58 A similar reduction in squalene epoxidase expression was also observed in Egr1 null mice

59 ating that the Chlorophycean violaxanthin de-epoxidase found in C. reinhardtii does not require Asc a

60 Two new sequences for violaxanthin de-epoxidase from tobacco and Arabidopsis are described.

61 fferent physical positions in the zeaxanthin epoxidase gene (ABSCISIC ACID DEFICIENT 1/ZEAXANTHIN EPO

62 Squalene epoxidase gene mutations associated with decreased terbi

63 The epoxidase gene was dispensable in a nematode-infective j

64 ons in the coding sequence of the zeaxanthin epoxidase gene, resulting in the constitutive accumulati

65 ants are new alleles of aba1, the zeaxanthin epoxidase gene.

66 Previously, violaxanthin de-epoxidase had been partially purified.

67 Violaxanthin de-epoxidase has an isoelectric point of 5.4 and an apparen

68 ment1 [hp1]), Deetiolated1 (hp2), Zeaxanthin Epoxidase (hp3), and Intense pigment (Ip; gene product u

69 The iron-dependent epoxidase HppE converts (S)-2-hydroxypropyl-1-phosphonat

70 (S)-2-Hydroxypropylphosphonic acid epoxidase (HppE) catalyzes the epoxide ring closure of (

71 (S)-2-Hydroxypropylphosphonic acid [(S)-HPP] epoxidase (HppE) is a mononuclear iron enzyme that catal

72 (S)-2-hydroxypropylphosphonate ((S)-2-HPP) epoxidase (HppE) is a mononuclear non-haem-iron-dependen

73 (S)-2-Hydroxypropylphosphonic acid epoxidase (HppE) is an O2-dependent, nonheme Fe(II)-cont

74 (S)-2-Hydroxypropylphosphonic acid epoxidase (HppE) is an unusual mononuclear iron enzyme t

75 Hydroxypropylphosphonic acid epoxidase (HppE) is an unusual mononuclear iron enzyme t

76 )-2-hydroxypropylphosphonic acid ((S)-2-HPP) epoxidase (HppE) is an unusual mononuclear non-heme iron

77 S)-2-Hydroxypropylphosphonate [(S)-2-HPP, 1] epoxidase (HppE) reduces H(2)O(2) at its nonheme-iron co

78 (TauD), (S)-(2)-hydroxypropylphosphonic acid epoxidase (HppE), and 1-aminocyclopropyl-1-carboxylic ac

79 ylphosphonic acid (HPP) to fosfomycin by HPP epoxidase (HppE), which is a mononuclear non-heme iron-d

80 pid synthesis (fatty acid synthase, squalene epoxidase, hydroxy-methylglutaryl coenzyme A reductase),

81 script and protein levels of violaxanthin de-epoxidase in the eIFiso4G loss of function mutant and an

82 xpression of monCI, encoding a flavin-linked epoxidase, in S. coelicolor was shown to significantly i

83 idual endogenous synthesis with the squalene epoxidase inhibitor NB-598 prevented growth in beta-sito

84 In contrast, HPP epoxidase is alpha-ketoglutarate independent.

85 tial biochemical evidence revealing that HPP epoxidase is an iron-dependent enzyme and that both NAD(

86 k data base and suggest that violaxanthin de-epoxidase is nuclear encoded, similar to other chloropla

87 ne monooxygenase (SM, also known as squalene epoxidase) is a rate-limiting enzyme of cholesterol synt

88 ion reaction of hydroxypropylphosphonic acid epoxidase may occur.

89 cies distribution and prevalence of squalene epoxidase mutations among toenail dermatophyte isolates.

90 ermatophyte species with or without squalene epoxidase mutations were detected using multiplex real-t

91 in reductase (SMOB) and FAD-specific styrene epoxidase (NSMOA).

92 ts for genes encoding either violaxanthin de-epoxidase or LHCX1 proteins exhibited strongly inhibited

93 e gene (ABSCISIC ACID DEFICIENT 1/ZEAXANTHIN EPOXIDASE, or ABA1/ZEP) in TG01 and TG10.

94 s with either of the two O. spinosa squalene epoxidases, OsSQE1 or OsSQE2, alpha-onocerin production

95 duction was boosted, most likely because the epoxidases produce higher amounts of squalene-2,3;22,23-

96 tion of the bifunctional C-methyltransferase/epoxidase PsoF to complete the trans to cis isomerizatio

97 emonstrate that a bespoke regioselective IDT epoxidase (RadM) acts at the terminal olefin of precurso

98 In vascular plants, violaxanthin de-epoxidase requires Asc as a reductant; thereby, Asc is r

99 um of oxidized iron-reconstituted fosfomycin epoxidase reveals resonances typical of S = (5)/(2) Fe(I

100 formation: squalene synthase (SS), squalene epoxidase (SE), and beta-amyrin synthase (beta-AS).

101 Glu substrate is present, the Leptospira VKD epoxidase showed unfettered epoxidation in the absence o

102 identified six putative Arabidopsis squalene epoxidase (SQE) enzymes and used heterologous expression

103 resistance due to mutations in the Squalene Epoxidase (SQLE) gene.

104 Squalene epoxidase (SQLE), also known as squalene monooxygenase,

105 esterol biosynthetic pathway enzyme squalene epoxidase (SQLE).

106 the long awaited structure of human squalene epoxidase (SQLE).

107 of the erg26 mutation into an erg1 (squalene epoxidase) strain also was viable in ergosterol-suppleme

108 from the studies on thiolate-heme containing epoxidases, such as cytochrome P450 epoxidases.

109 by ( S)-2-hydroxypropylphosphonic acid (HPP) epoxidase ( Sw-HppE).

110 ight polyketide synthase modules, and a P450 epoxidase that converts desoxyepothilone into epothilone

111 LOS6/ABA1 encodes a zeaxanthin epoxidase that functions in ABA biosynthesis.

112 KD carboxylase is bifunctional, acting as an epoxidase that oxygenates vitamin K to a strong base and

113 uggests that CVDE evolved from an ancient de-epoxidase that was present in the common ancestor of gre

114 ne monooxygenase (SM, also known as squalene epoxidase), the rate-limiting enzyme of the committed ch

115 ated the npq1 mutant lacking violaxanthin de-epoxidase, the npq4 mutant lacking PsbS protein, and the

116 light oscillations involves violaxanthin de-epoxidase to produce, presumably, a largely stationary l

117 that, in contrast to dicots, root zeaxanthin epoxidase transcripts were unchanged.

118 e for the synthesis of mogroside V: squalene epoxidases, triterpenoid synthases, epoxide hydrolases,

119 port a detailed characterization of the CrpE epoxidase using an engineered maltose binding protein (M

120 transthylakoid delta pH and violaxanthin de-epoxidase (VDE) activity.

121 Violaxanthin de-epoxidase (VDE) is a lumen-localized enzyme that catalyz

122 Violaxanthin de-epoxidase (VDE) is the key enzyme responsible for zeaxan

123 our beta-carotene hydroxylase and zeaxanthin epoxidase were ranked first and forty-fourth respectivel

124 iolaxanthin to zeaxanthin is violaxanthin de-epoxidase, which is located in the thylakoid lumen, is a

125 Among these is hydroxypropylphosphonic acid epoxidase, which represents a new subfamily of non-haem

126 Coexpression of this epoxidase with a noncanonical type II TC RadB led to the

127 ity of terbinafine, an inhibitor of squalene epoxidase within the sterol biosynthesis pathway, but ha

128 ding the ABA biosynthetic enzymes zeaxanthin epoxidase (ZEP) and 9-cis-epoxycarotenoid dioxygenase (N

129 acid (ABA) biosynthesis pathway, zeaxanthin epoxidase (ZEP) and 9-cis-epoxycarotenoid dioxygenase (N

130 Since zeaxanthin epoxidase (ZEP) depletes the carotenoid pool in subseque

131 ZEAXANTHIN EPOXIDASE (ZEP) was the major contributor to carotenoid