ライフサイエンスコーパス: epoxide

1 ith good leaving groups (e.g. vinyl chloride epoxide).

2 e preferentially opens cyclic anhydride over epoxide.

3 a simple oxyanion that is generated from an epoxide.

4 of an inverse rate order with respect to the epoxide.

5 family enzymes, which can metabolize PUFA to epoxides.

6 lysis in cycloaddition reactions of CO2 with epoxides.

7 r efficiently catalyzing the methanolysis of epoxides.

8 ite IRA 400 HO(-) to yield the series 1 diol epoxides.

9 r ring-opening copolymerization (ROCOP) with epoxides.

10 ion studies and the application of exogenous epoxides.

11 ines from anilines and aromatic or aliphatic epoxides.

12 r 5-exo cyclizations of suitably unsaturated epoxides.

13 putative OBPs, that is, carbamazepine 10,11-epoxide, 10,11-Dihydrocarbamazepine, 1-(2-benzaldehyde)-

14 ers are prepared from a pivotal intermediate epoxide 12.

15 We show that one of these analogues, CDDO-epoxide (13), is comparable to 4 in terms of cytotoxicit

16 lammation studies revealed that the terminal epoxides 17,18-EEQ-EA and 19,20-EDP-EA dose-dependently

17 Furthermore the omega-3 endocannabinoid epoxides 17,18-EEQ-EA and 19,20-EDP-EA exerted antiangio

18 Cholesterol-5,6-epoxide (5,6-EC) metabolism is deregulated in BC but the

19 eriments and on an experiment with CBZ-10,11-epoxide a transformation pathway of CBZ in intact tomato

20 efins containing an alcohol, an aldehyde, an epoxide, a carboxylic acid, or an alkenyl group may be u

21 dependence of the polymerization rate on the epoxide, a zero-order dependence on the cyclic anhydride

22 Application to conduritol B epoxide-, a beta-glucocerebrosidase inhibitor, treated R

23 The quantitative isolation of the epoxides, accomplished by solvent precipitation of triet

24 presence of esters, nitriles, alkyl halides, epoxides, acetals, alkenes, aryl halides, and silyl ethe

25 fect of the five metal ions as Lewis acid in epoxide activation.

26 eroxides, hydroxy-dienes and other alcohols, epoxides, aldehydes and keto-dienes, was followed by (1)

27 ere, we synthesized manno-epi-cyclophellitol epoxide and aziridines and demonstrate their covalent mo

28 While epoxide and diol levels were comparable in tumors from b

29 ass of compounds in diet-induced obesity-C18 epoxide and diol oxylipins.

30 argeting the enzymes involved in cholesterol epoxide and glucocorticoid metabolism or GR may be novel

31 Reactivities of epoxide and ketone functional groups on the cycloheptane

32 ted ixabepilone analogues in which the 12,13-epoxide and macrolactam NH moieties were replaced, the f

33 eds in a kinetic resolution, furnishing both epoxide and thiirane in high yields and enantiomeric pur

34 y oxidation products such as some aldehydes, epoxides and alcohols.

35 ains having also hydroperoxy/hydroxy groups, epoxides and aldehydes); the formation of hydroxides was

36 e stereoselective union of readily available epoxides and allyl electrophiles is disclosed.

37 conditions, it was also possible to convert epoxides and an oxetane to the dichlorinated products.

38 Testing a range of anhydrides, epoxides and chain-transfer agents reveals some of the r

39 Using the cycloaddition of the epoxides and CO2 as a model reaction, dramatic activity

40 ity for the ring-opening copolymerization of epoxides and cyclic anhydrides at low concentrations (>=

41 through the alternating copolymerization of epoxides and cyclic anhydrides compose a growing class o

42 enabled the ring-opening copolymerization of epoxides and cyclic anhydrides to afford structurally an

43 he copolymerization of a variety of terminal epoxides and cyclic anhydrides.

44 such as the alternating copolymerization of epoxides and cyclic anhydrides.

45 Epoxides and diepoxides were clearly identified from bet

46 ent photoredox catalyst for the reduction of epoxides and for 5-exo cyclizations of suitably unsatura

47 e selective hydroboration of a wide range of epoxides and oxetanes yielding secondary and tertiary al

48 ctivity (up to s = 93), giving the unreacted epoxides and the corresponding protected 1,2-diols in hi

49 tes (diaminothiazine [DIAT], N-acetyl DIAT & epoxide) and cloning was attempted in a number of patien

50 ion is converted into either a trans- or cis-epoxide, and these are subsequently converted to (+)-ant

51 he reactions of alpha-lithiated haloalkanes, epoxides, and carbamates.

52 o many other lactones, lactides, anhydrides, epoxides, and heterocumulenes and sets the scene for a h

53 ne was the Lewis acid chosen to activate the epoxides, and onium halides or onium alkoxides involving

54 etones, pyridinium salts, Michael acceptors, epoxides, and Pd-catalyzed Sonogashira couplings.

55 an alkB biocathode which produces alcohols, epoxides, and sulfoxides through bioelectrochemical hydr

56 pective on the current state of the field of epoxide/anhydride copolymerization mediated by discrete

57 sters via the copolymerization of a range of epoxide/anhydride monomer pairs.

58 and ring-opening copolymerization (ROCOP) of epoxides, anhydrides, and CO2 is investigated, using bot

59 ZTI-01 (fosfomycin for injection) is an epoxide antibiotic with a differentiated mechanism of ac

60 ncluding olefins, alkynes, heterocycles, and epoxides are competent traps in the bromonium-induced cy

61 The omega-3 endocannabinoid epoxides are derived from docosahexaenoic acid (DHA) and

62 In summary, the omega-3 endocannabinoid epoxides are found at concentrations comparable to those

63 r inherent ring strain and electrophilicity, epoxides are highly attractive building blocks for funda

64 Levels of DHA-derived epoxides are lower in colon tissues from patients with U

65 er (HAT) in favor of addition, such that the epoxides are the major products.

66 Epoxides are useful intermediates for the manufacture of

67 a thermal rearrangement of cyclopentadienone epoxides as key step.

68 cs, we identify omega-3 (omega-3) fatty acid epoxides as new mast cell-derived lipid mediators and sh

69 cleavage in the hydroboration of esters and epoxides at room temperature.

70 e-pot, sequential protocol was developed for epoxide azidolysis and copper-catalyzed azide-alkyne cyc

71 an approach based on rarely studied terminal epoxide-based cation-pai bicyclizations that is describe

72 icomponent photoresins include acrylate- and epoxide-based monomers with corresponding radical and ca

73 als that the alcohol chain ends compete with epoxide binding to the Lewis acid and hydrogen-bond with

74 Benzo[a]pyrene,diol epoxide (BPDE) is a potent cigarette smoke carcinogen th

75 tabolite benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), using methodology applicable to correlat

76 tabolically activated to benzo[a]pyrene diol epoxide (BPDE), which then can react with DNA to form ca

77 ic monomers such as lactones, carbonates, or epoxides but also to trigger the step-growth synthesis o

78 In addition, ring-opening of epoxide by an intermediate comprising multiple carboxyla

79 ation of the more potently antibacterial cis-epoxide by radicaloid C-O coupling.

80 Using an approach based on the activation of epoxides by Lewis acids and of CO2 by appropriate cation

81 polymerization of carbonyl sulfide (COS) and epoxides by metal-free Lewis pair catalysts composed of

82 an example, it is applied to the opening of epoxides by titanocene in THF, a catalytic system with a

83 his isomerization is a dihydroxy hydroperoxy epoxide (C5H10O5), which is expected to have a saturatio

84 A wide range of epoxides can be carbonylated to beta-lactones, which are

85 Various alkyl-substituted cis- and trans-epoxides can be reduced to trans- and cis-alkenes, respe

86 functional groups including ethers, esters, epoxides, carbamates, and phthalimides.

87 Motivated by stereoinvertive epoxide carbonylation reactions, we developed a two-step

88 In addition other 5,6-epoxide carotenoids, such as (all-E)-neoxanthin, (9'Z)-n

89 mechanism-based GBA inhibitors, conduritol B epoxide (CBE), and cyclophellitol.

90 ation of the GCase inhibitor conduritol beta-epoxide (CBE), as well as the nonlysosomal beta-glucosid

91 idase (GCase) in N2a cells with conduritol B epoxide (CBE).

92 copolymerization of EO or PO with functional epoxide comonomers are presented as well as complex bran

93 ) irradiation, a combination of acrylate and epoxide components are incorporated.

94 trans-stilbene (compound 1) and its stilbene epoxide (compound 2).

95 hesis and anticancer evaluation of all known epoxide-containing communesin alkaloids and related deri

96 approach enabled the rapid synthesis of all epoxide-containing members of the communesin family from

97 iated roles for the metals in the mechanism: epoxide coordination occurs at Mg(II), with reduced tran

98 Carbon dioxide/epoxide copolymerization is an efficient way to add valu

99 Carbon dioxide and epoxide copolymerization is an industrially relevant mea

100 iolaxanthin cycle (VAZ cycle) and the lutein epoxide cycle (LxL cycle) are two xanthophyll cycles fou

101 accumulates lutein via an engineered lutein epoxide cycle.

102 butane pyrimidine dimers (CPDs) and BaP diol epoxide-deoxyguanosine (BPDE-dG), which are removed from

103 Our results also demonstrate that epoxide derivatives can be formed as intermediates or by

104 Epoxyoctadecamonoenoic acids (EpOMEs) are epoxide derivatives of linoleic acid (9,12-octadecadieno

105 Hence, its epoxide derivatives should serve as promising monomers f

106 identified 3 new pathways producing allylic epoxide-derived mediators that stimulate regeneration [i

107 Epoxide, dicarbonyl, and secondary ozonide THC reaction

108 which GCase was inhibited by conduritol beta-epoxide did not increase the amount of insoluble monomer

109 he detection of benzo[a]pyrene-7,8-diol 9,10-epoxide-DNA adduct (BPDE-DNA), which is a metabolite of

110 ioselective transformations of disubstituted epoxides, emphasizing those that have inspired the produ

111 The epoxide exhibited reduced cytotoxicity toward its produc

112 d Meinwald rearrangement of tetrasubstituted epoxides for the synthesis of enantioenriched 2-alkynyl-

113 lic activation of aflatoxin B1 (AFB1) to its epoxide form that reacts with N7 guanine in DNA.

114 Retention of C1 configuration and trans-epoxide formation become predominant with the bulk-reduc

115 es ~95% selectivity for C1 inversion and cis-epoxide formation via steric guidance of a radical-coupl

116 this includes diastereo- and regioselective epoxide formation/trichloroacetic acid cleavage to gener

117 bon center in citridone B is catalyzed by an epoxide-forming P450 enzyme, followed by carbon skeletal

118 olation of various thymine and thymidine 5,6-epoxides from the corresponding trans-5,6-bromohydrins b

119 hydic H-shift and ring-closure to produce an epoxide functionality could be competitive with classic

120 fatty amides, aldehydes, ketones, alcohols, epoxides, furans, pyrans and terpenic oxygenated derivat

121 Arachidonic acid epoxides generated by cytochrome P450 (CYP) enzymes have

122 ikely attributable to the corresponding PUFA epoxides generated in tumor cells and/or host, since man

123 rly stage introduction of the trisubstituted epoxide group is reported, allowing access to the natura

124 and cis-nonachlors (TN, CN), heptachlor exo-epoxide (HEPX), dieldrin (DIEL), chlorobornanes (SigmaCH

125 mediates shed some light on the mechanism of epoxide hydrogenolysis, and further, deuterium labeling

126 We show that cholesterol epoxide hydrolase (ChEH) metabolizes 5,6-EC into cholest

127 uctural underpinnings of the enzyme's unique epoxide hydrolase (EH) activity, involving Zn(2+), Y383,

128 of neonatal faeces indicated that bacterial epoxide hydrolase (EH) genes are more abundant in the gu

129 depended upon co-administration of a soluble epoxide hydrolase (EPHX2) inhibitor in males, and/or wer

130 (SIM) to study the kinetics of human soluble epoxide hydrolase (hsEH), an enzyme involved in cardiova

131 Juvenile hormone epoxide hydrolase (JHEH) has attracted great interest be

132 are hydrolyzed to diols by human microsomal epoxide hydrolase (mEH).

133 A soluble epoxide hydrolase (Se-sEH) of S. exigua was predicted an

134 n of dual-target ligands that target soluble epoxide hydrolase (sEH) and the peroxisome proliferator-

135 Here we identify soluble epoxide hydrolase (sEH) as a key enzyme that initiates p

136 Herein, using the human soluble epoxide hydrolase (sEH) as a model analyte, we found tha

137 Using human soluble epoxide hydrolase (sEH) as a model antigen, we were able

138 l trials combined with inhibition of soluble epoxide hydrolase (sEH) as anti-inflammatory strategy pr

139 enetic ablation or inhibition of the soluble epoxide hydrolase (sEH) enzyme led to increased levels o

140 HA metabolism by cytochrome P450 and soluble epoxide hydrolase (sEH) enzymes affects retinal angiogen

141 revious study showed that inhibiting soluble epoxide hydrolase (sEH) increased EET concentration and

142 Soluble epoxide hydrolase (sEH) inhibitors, which increase endog

143 The emerging pharmacological target soluble epoxide hydrolase (sEH) is a bifunctional enzyme exhibit

144 Soluble epoxide hydrolase (sEH) is a bifunctional enzyme located

145 of the cyclooxygenase-2 (COX-2) and soluble epoxide hydrolase (sEH) pathways prevented the debris-in

146 erging of 5-lipoxygenase (5-LOX) and soluble epoxide hydrolase (sEH) pharmacophores led to the discov

147 n vivo pharmacological inhibition of soluble epoxide hydrolase (sEH) reduces inflammatory diseases, i

148 r studies identified oxamide 2b as a soluble epoxide hydrolase (sEH) stable replacement but unsuitabl

149 ompounds, which are converted by the soluble epoxide hydrolase (sEH) to dihydroxylethersatrienoic aci

150 ne, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of

151 -regulates cyclooxygenase-2 (COX-2), soluble epoxide hydrolase (sEH), ER stress-response genes includ

152 onooxygenases (CYPs) and degraded by soluble epoxide hydrolase (sEH).

153 ice by pharmacological inhibition of soluble epoxide hydrolase (sEH, EPHX2).

154 Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN

155 e hydrolase activity of M. thermoresistibile epoxide hydrolase A (Mth-EphA) and report its crystal st

156 Here, we demonstrate epoxide hydrolase activity of M. thermoresistibile epoxi

157 lipogenesis activity and a shift in soluble epoxide hydrolase and lipoxygenase activity.

158 oli expressing recombinant Aspergillus niger epoxide hydrolase as the model enzyme for various enanti

159 nd immunological evidence that the bacterial epoxide hydrolase Cif disrupts resolution pathways durin

160 he hypotheses that inhibition of the soluble epoxide hydrolase enzyme can result in an increase in th

161 The soluble epoxide hydrolase enzyme catalyzes the hydrolysis of ant

162 al explanation for the genetic repertoire of epoxide hydrolase genes in M. tuberculosis.

163 cificity that implicates participation of an epoxide hydrolase in converting epoxyalcohol to triol.

164 Treatment with soluble epoxide hydrolase inhibitor significantly reduces the ac

165 respectively) in the cytochrome P450/soluble epoxide hydrolase pathway.

166 e report findings that inhibition of soluble epoxide hydrolase reduces inflammation, oxidative stress

167 eficial biofilm was engineered to produce an epoxide hydrolase so that it efficiently removes the env

168 Here, we show that a secreted P. aeruginosa epoxide hydrolase, cystic fibrosis transmembrane conduct

169 es, a reaction specificity characteristic of epoxide hydrolase.

170 identified inhibitors of the enzyme soluble epoxide hydrolase.

171 s M. tuberculosis has six putative genes for epoxide hydrolases (EH) of the alpha/beta-hydrolase fami

172 s the founding member of a distinct class of epoxide hydrolases (EHs) that triggers the catalysis-dep

173 squalene epoxidases, triterpenoid synthases, epoxide hydrolases, cytochrome P450s, and UDP-glucosyltr

174 It catalyzes epoxide hydrolysis, but there is no known role for natur

175 ido)-dodecanoic acid (AUDA), an inhibitor of epoxide hydrolysis, inhibited VCAM-1 and ICAM-1 expressi

176 from succinic acid and an ether-substituted epoxide (hydrophile).

177 A catalytic system for titanocene-catalyzed epoxide hydrosilylation is described.

178 groundbreaking examples include the role of epoxides in aerosol formation especially from isoprene,

179 ysis, but there is no known role for natural epoxides in CFTR regulation.

180 drogen peroxide, providing the corresponding epoxides in good to excellent yields and enantioselectiv

181 ar crossover reaction delivers corresponding epoxides in good to high enantioselectivity and constitu

182 onal groups, including an alcohol, aldehyde, epoxide, indole, nitroalkane, and sulfide.

183 ce using the covalent inhibitor conduritol-B-epoxide induced a profound increase in soluble alpha-syn

184 two critical construction reactions: (1) an epoxide-initiated, beta-ketoester-terminated polycycliza

185 subsequent C3-O bond formation completes the epoxide installation.

186 ompounds we found that the synthetic maresin epoxide intermediate 13S,14S-eMaR (13S,14S-epoxy- 4Z,7Z,

187 nal enzyme that converts the highly unstable epoxide intermediate LTA4 into LTB4, a potent leukocyte

188 on in which isocyanides are able to open the epoxide intermediate of the Bargellini reaction affordin

189 he hydrogenolysis between two diastereomeric epoxide intermediates shed some light on the mechanism o

190 it is established that the isomerization of epoxides into allylic alcohols catalyzed by supported Au

191 Conduritol B epoxide is an inhibitor of acid beta-glucosidase, and lo

192 The first step of the ring opening of the epoxide is the rate-determining step of these reactions.

193 On-demand formation of mono-/multiple epoxides is achieved at different voltages.

194 Metalations of arenes, epoxides, ketones, hydrazones, dienes, and alkyl and vin

195 ways, particularly for the abeo-abietane tri-epoxide lactone triptolide.

196 The trans- and cis-epoxides lead to opposite ( syn and anti) diastereoisome

197 duced the steady-state production of omega-3 epoxides, leading to attenuated mast cell activation and

198 es, and/or were associated with increases in epoxide levels in tumors and sites of metastasis.

199 are proposed to act via a 1,2-anhydrosugar "epoxide" mechanism that proceeds through an unusual conf

200 uct formed between deoxyguanosine and a diol epoxide metabolite of BaP, with subsequent mutation of c

201 Four TPs (carbamazepine-10,11-epoxide, metoprolol acid, 1-naphthol, and saluamine) wer

202 various electrophiles such as alkyl halides, epoxides, Michael acceptors, and lambda(3)-iodanes in mo

203 Conduritol B epoxide mitigated gene dysregulation in the spinal cord

204 tical feature followed by the presence of an epoxide moiety at a terminal position.

205 n-dependent RslO5 reductively ring-opens the epoxide moiety of an advanced polycyclic intermediate to

206 wed by tungsten-induced deoxygenation of the epoxide moiety.

207 We describe a novel epoxide monomer with methyl-thioether moiety, 2-(methylt

208 ith a particular focus on the most important epoxide monomers ethylene oxide (EO), propylene oxide (P

209 tion of multimaterial parts containing stiff epoxide networks contrasted against soft hydrogels and o

210 IEPOX was assessed through a series of model epoxide-nucleophile experiments using nuclear magnetic r

211 shift was observed directly adjacent to the epoxide-nucleophile linkage, with smaller decreases in c

212 ly, the linoleic acid metabolite 9,10-EpOME (epoxide of linoleic acid) as well as the lysophospholipi

213 rsion of configuration at C1, yields the cis-epoxide of the drug [(1R,2S)-epoxypropylphosphonic acid

214 ed access to the oppositely configured 12,13-epoxides of 12-epoxyobtusallene II and 12-epoxyobtusalle

215 epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the cor

216 rategies involving BF3.Et2O-catalyzed ketone-epoxide opening and gold-catalyzed glycosylation reactio

217 The same sequence employing an epoxidation/epoxide opening in place of dihydroxylation furnishes ma

218 rayed involving a radical-mediated reductive epoxide opening reaction of N-tethered epoxy-indoles tha

219 able Mukaiyama aldol reaction, Nicolaou-type epoxide opening reaction, stereoselective Corey-Chaykovs

220 e the C7 stereocenter and a stereoconvergent epoxide opening to establish the trans-diaxial diol func

221 v alcohols by combining titanocene-catalyzed epoxide opening with chromium-catalyzed hydrogen activat

222 e key transformations used, a regioselective epoxide opening, a Pd-catalyzed addition of terminal alk

223 se I, inspired by the proposed biosynthesis, epoxide-opening cascades assemble 10 out of 15 cyclic et

224 l products involves a kinetically disfavored epoxide-opening cyclic ether formation, a reaction terme

225 plings, reductive ketone deoxygenations, and epoxide openings.

226 inly from cyclopropanols, cyclopropenols and epoxides or aziridines are applied to the synthesis of a

227 ycosylation with Schmidt-type donors, glycal epoxides, or under dehydrative conditions with C1 alcoho

228 lize the first dyotropic rearrangement of an epoxide-oxetane substrate.

229 lymerization, and cationic polymerization of epoxides (oxiranes), are briefly reviewed.

230 Taken together, the omega-3 endocannabinoid epoxides' physiological effects are mediated through bot

231 n the iron(II) oxidation state and selective epoxide polymerization was observed in the iron(III) oxi

232 With the ever growing toolbox for epoxide polymerization, a "polyether universe" may be en

233 ent and in some cases metal-free methods for epoxide polymerization, i.e., the activated monomer stra

234 GST)2, mGST3, and GST-mu (GSTM)4] from their epoxide precursors [16S,17S-epoxy-PD (ePD) and 13S,14S-e

235 amyotrophic lateral sclerosis, conduritol B epoxide preserved ganglioside distribution at the neurom

236 ge-fleshed fruit, whereas several carotenoid epoxides prevailed in yellow-fleshed fruit.

237 ntroduction of a vinyl or allyl group to the epoxide produced the diene derivatives that were subject

238 Mechanistically, the omega-3 epoxides promote IgE-mediated activation of mast cells b

239 The diol:epoxide ratios suggest the sEH activity is higher in AN

240 Vitamin K epoxide reductase (VKOR) drives the vitamin K cycle, act

241 d revealed the essential role of a vitamin K epoxide reductase (VKOR) gene in pilus assembly.

242 Vitamin K epoxide reductase (VKOR) is an essential enzyme for vita

243 Human vitamin K epoxide reductase (VKOR) is the target of warfarin.

244 vIL-6 with the ER membrane protein vitamin K epoxide reductase complex subunit 1 variant 2 (VKORC1v2)

245 ncharacterized ER membrane protein vitamin K epoxide reductase complex subunit 1 variant 2 (VKORC1v2)

246 ith a nonsignaling receptor called vitamin K epoxide reductase complex subunit 1 variant 2 (VKORC1v2)

247 and the novel ER membrane protein vitamin K epoxide reductase complex subunit 1 variant-2 (VKORC1v2)

248 ly used anticoagulants that target vitamin K epoxide reductases (VKOR), a family of integral membrane

249 To understand how QueG is able to perform epoxide reduction, an unprecedented reaction for a Cbl-d

250 Following foundational work on epoxide reductive functionalization, recent methodologic

251 d for 60 nm thick ultramicrotome sections of epoxide resin on pre-patterned glass substrates.

252 tic activities of LTA4H, alternating between epoxide ring opening and peptide bond hydrolysis, assist

253 A sequence of epoxide ring opening using N-deprotonated 1,2-azaborines

254 rogen-bond with anionic chain ends to impede epoxide ring opening.

255 on catalyst on the regioselectivities of the epoxide ring-opening and acylation steps.

256 Mechanistic studies revealed epoxide ring-opening as the turnover limiting step, an i

257 ard sequential reactions with a nucleophile (epoxide ring-opening by chloride) and an electrophile (O

258 loits mechanistic switches between anhydride/epoxide ring-opening copolymerization, epoxide ring-open

259 dride/epoxide ring-opening copolymerization, epoxide ring-opening polymerization and lactone ring-ope

260 A long-known one-pot epoxidation/epoxide ring-opening/pinacol-pinacolone rearrangement of

261 poxidation and elaborated via regioselective epoxide-ring opening and diastereoselective bromoetherif

262 onyl-phenol adducts were produced firstly by epoxide-ring opening initiated by the attack of one phen

263 n by chloride-assisted glycidol rupture (the Epoxide Route) and compared it with pH measurements by c

264 Here, we report an indole-based quinone epoxide scaffold with a unique boat-like conformation th

265 tural analysis and comparison with unreacted epoxides show that this compound indeed binds in the (4)

266 Thus, the PAF-AH2-omega-3 epoxide-Srcin1 axis presents new potential drug targets

267 no lesion formed in the reaction of DNA with epoxides substituted with good leaving groups (e.g. viny

268 Epoxide substrates of sEH and associated oxylipins were

269 tion pathway starts with the formation of an epoxide that is opened upon the addition of a second equ

270 s well as an assortment of 2,2-disubstituted epoxides that contain an easily modifiable alkene.

271 ugh derived specifically from the opening of epoxides, the prediction capabilities of the model, buil

272 recyclable catalyst for CO(2) fixation with epoxides; there is no significant loss of catalytic acti

273 (24) comprise two steps: ring opening of the epoxide to a carbocation intermediate followed by migrat

274 mediated reductive radical cyclization of an epoxide to furnish the drimene core.

275 selective carbonylation of 2,2-disubstituted epoxides to beta,beta-disubstituted beta-lactones.

276 ed to the kinetic resolution of select trans-epoxides to give synthetically useful selectivity factor

277 e generated in situ and can catalyze various epoxides to give the corresponding beta-hydroxyesters in

278 within cytosol and peroxisomes that converts epoxides to the corresponding diols and hydrolyzes phosp

279 ective Bronsted acid catalyzed conversion of epoxides to thiiranes has been developed.

280 anthin (all-E)-antheraxanthin and lutein 5,6-epoxide, together with (all-E)-lutein, (all-E)-zeaxanthi

281 olling the regioselectivity of disubstituted epoxide transformations is often particularly challengin

282 The opening of epoxides typically requires electrophilic activation, an

283 ulin, dihydrobetulinic acid, and abeo-lupane epoxides under acidic conditions (HCl, montmorillonite K

284 Specifically, the substitutions of the epoxide units and lactone moieties with cyclopropyl and

285 rization of a broad array of monomers (e.g., epoxides, vinyl ethers, alkenes, cyclic ethers, and lact

286 The pivotal epoxide was used as a common intermediate to accomplish

287 d stereoselective nucleophilic opening of an epoxide were used as the main transformations.

288 Enantiopure epoxides were demonstrated to undergo the carbonylation/

289 -epoxy-4-oxo-beta-apo-11-carotenal, no other epoxides were detected.

290 was active for the polymerization of various epoxides, whereas the analogous neutral iron(II) complex

291 sesquiterpene metabolism to a sesquiterpene epoxide, which we designate arteannuin X.

292 lesterol, the stereoisomeric cholesterol-5,6-epoxides, which account for 12% of the oxidation product

293 we developed a kinetic resolution of racemic epoxides, which proceeds with high selectivity (up to s

294 Their epoxidation afforded epoxides, which, in the presence of protic or Lewis acid

295 f the corresponding activated aziridines and epoxides with amines followed by p-toluenesulfonic acid

296 and selective in copolymerizations of other epoxides with carbon dioxide.

297 time through the anionic copolymerization of epoxides with CO2, under metal-free conditions.

298 ring-opening alternating copolymerization of epoxides with cyclic anhydrides.

299 oboration reaction of aliphatic and styrenic epoxides with pinacolborane (HBpin).

300 g a comprehensive review on the reactions of epoxides with titanium(III) reagents, we encountered a s