ライフサイエンスコーパス: erythrocytic

1 g., plasma-derived butyrylcholinesterase and erythrocytic acetylcholinesterase) or nonexisting (synap

2 ncode a multiepitope string fused to the pre-erythrocytic Ag thrombospondin-related adhesion protein.

3 der the curve (AUC) of 0.62, indicating that erythrocytic alpha-syn levels alone are not sufficient f

4 ifiable by their likely biological action as erythrocytic (also associated with erythrocyte traits) o

5 ates were higher in 2003 than 2013 for 1 pre-erythrocytic and 7 blood-stage antigens.

6 lood flow reactivity, involve many vascular, erythrocytic and cerebral tissue mechanisms that mediate

7 MBCs and antibodies recognizing pre-erythrocytic and cross-stage antigens were gradually acq

8 The critical involvement of SUB1 in both pre-erythrocytic and erythrocytic developmental phases quali

9 t Plasmodium falciparum parasites in the pre-erythrocytic and erythrocytic stages, with some research

10 falciparum vaccine that targets both the exo-erythrocytic and erythrocytic stages.

11 Numerous pre-erythrocytic and erythrocytic vaccine candidates have be

12 n, next-generation drugs active against both erythrocytic and exo-erythrocytic forms would be prefera

13 We report compounds active against both the erythrocytic and exoerythrocytic forms of malaria parasi

14 5p (IC50 values of 54 and 710 nM against the erythrocytic and exoerythrocytic forms), which constitut

15 The erythrocytic and exoerythrocytic protein chimeras descri

16 cytoplasmic foci adjacent to the nucleus in erythrocytic and liver stage parasites, and throughout t

17 tion of lineage-restricted precursors of the erythrocytic and myelopoietic lineages.

18 ncing selection was detected for most of the erythrocytic and pre-erythrocytic antigens.

19 multistage malaria vaccine targeting the pre-erythrocytic and sexual stages of Plasmodium could effec

20 able of delivering a potent antimalarial pre-erythrocytic and TB response via a single immunization r

21 t to the plasma membrane of aspartate 821 in erythrocytic anion exchanger has been determined by labe

22 Novel pre-erythrocytic antibody (Ab) targets could be key to impro

23 ile of seven novel Plasmodium falciparum pre-erythrocytic antigens and their potential association wi

24 IgG antibodies to pre-erythrocytic antigens are involved in prevention of infe

25 volunteers reacted strongly against the pre-erythrocytic antigens circumsporozoite protein (CSP) and

26 stage antigen 1 (LSA1) is one of several pre-erythrocytic antigens considered for inclusion in a mult

27 ith high levels of IgG antibodies to the pre-erythrocytic antigens CSP, LSA-1, and TRAP have a lower

28 lular immune response to blood-stage and pre-erythrocytic antigens longitudinally from 1 to 3 years o

29 ar sequence of subunit immunization with pre-erythrocytic antigens of Plasmodium berghei, consisting

30 ility of eight alternative P. falciparum pre-erythrocytic antigens to induce a high proportion of CD8

31 ia (aHR 0.96, P = .83), but responses to pre-erythrocytic antigens were associated with protection af

32 IFNgamma responses to pre-erythrocytic antigens were infrequent and similar betwee

33 Well classified merozoite and erythrocytic antigens were strongly reactive in semi-imm

34 Responses to pre-erythrocytic antigens were uncommon, not associated with

35 traditionally focused on two well-known pre-erythrocytic antigens, CSP and TRAP, yet thousands of ge

36 immunoglobulin G against preerythrocytic and erythrocytic antigens.

37 etected for most of the erythrocytic and pre-erythrocytic antigens.

38 semi-immune individuals mainly react against erythrocytic antigens.

39 line that was highly effective against intra-erythrocytic asexual blood-stage parasites, until resist

40 ight on an important role for PfCDPK7 in the erythrocytic asexual cycle of malaria parasites.

41 tire parasite lifecycle, including the intra-erythrocytic asexual forms responsible for disease, the

42 DNA and expression of only the A gene during erythrocytic asexual growth.

43 The erythrocytic asexual reproduction cycle of Plasmodium fa

44 gens corresponding to the sporozoite, liver, erythrocytic asexual, and sexual stages.

45 . falciparum at three time points during its erythrocytic (asexual) cycle.

46 Binding of erythrocytic beta-actin to ezrin is saturable with a mol

47 HbA1c and that HbA1c variants implicated in erythrocytic biology would affect the diagnostic accurac

48 e membrane surrounding the merozoites is not erythrocytic but rather is derived from the parasitophor

49 RNA levels as parasites progress through the erythrocytic cell cycle and examined this process in two

50 d another red cell disease to the panoply of erythrocytic changes that give rise to resistance to mal

51 Phenotypic whole-cell screening in erythrocytic cocultures of Plasmodium falciparum identif

52 oper targeting of parasite proteins to intra-erythrocytic compartments, including the apicoplast, a p

53 In a synchronized erythrocytic culture of P. falciparum, the PfP2 protein

54 Erythrocytic CYB5R enzyme activities were low in all dog

55 the plastid-like genome is essential for the erythrocytic cycle and presents a novel therapeutic site

56 The erythrocytic cycle of Pbyop1Delta parasites is severely

57 parum is derived from studies of the asexual erythrocytic cycle of the parasite, the portion of the p

58 sential for the completion of the parasite's erythrocytic cycle that causes disease in humans.

59 of nucleosome occupancy across the parasite erythrocytic cycle using two complementary assays--the f

60 Midway during the erythrocytic cycle, at the highly transcriptionally acti

61 t affect parasite replication throughout the erythrocytic cycle, gametocyte production, mosquito infe

62 pression of probable variant antigens in the erythrocytic cycle, modifies the elicited mammalian immu

63 Within the asexual erythrocytic cycle, responsible for the clinical manifes

64 at every morphological stage of the parasite erythrocytic cycle.

65 ver control massive transcription during the erythrocytic cycle.

66 of four parasite aminopeptidases during the erythrocytic cycle.

67 at a relatively steady level throughout the erythrocytic cycle.

68 DNA that mark the reproductive phase of the erythrocytic cycle.

69 preventing schizont rupture and blocking the erythrocytic cycle.

70 a single active var gene locus through many erythrocytic cycles and also achieve successive switchin

71 nts, here we report beta(IV)-spectrin, a non-erythrocytic cytoskeletal protein, as a critical regulat

72 Circulating hemoglobin and heme represent erythrocytic danger-associated molecular pattern (eDAMP)

73 Congenital methemoglobinemia caused by an erythrocytic deficiency of cytochrome b5 reductase (b5R;

74 ding both LipDHs, are transcribed during the erythrocytic development of P. falciparum.

75 t roles in regulating gene expression during erythrocytic development of the malaria parasite.

76 fferentially expressed in gametocytes during erythrocytic development of the parasite.

77 P. falciparum and was lethal for their intra-erythrocytic development, corroborating the suggestion t

78 During intra-erythrocytic development, malaria trophozoites digest he

79 g untimely PKA activation during early intra-erythrocytic development.

80 n the early and late stages of P. falciparum erythrocytic development.

81 is pathway is not functionally important for erythrocytic development.

82 hlighting an important bottleneck during pre-erythrocytic development.

83 Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 2

84 lvement of SUB1 in both pre-erythrocytic and erythrocytic developmental phases qualifies SUB1 as an a

85 ter multiple aspects of the parasite's intra-erythrocytic developmental program.

86 atically digests hemoglobin during its intra-erythrocytic developmental stages in acidic food vacuole

87 -specific transcription factor essential for erythrocytic differentiation at relatively early stages,

88 mosquito-borne transmission depends on intra-erythrocytic differentiation into non-replicating sexual

89 During erythrocytic differentiation of murine erythroleukemia (

90 in iron metabolism, hepatocyte function, and erythrocytic differentiation.

91 e number of megakaryocytes, and an arrest in erythrocytic differentiation.

92 y of S-nitrosohaemoglobin is promoted by the erythrocytic export of S-nitrosothiols.

93 of multiple lymph nodes, splenomegaly due to erythrocytic extramedullary hematopoiesis, and lymphoid

94 , associated with depletion of hematopoietic erythrocytic foci.

95 The evidence for and against a quiescent pre-erythrocytic form of P. malariae is reviewed.

96 alaria (defined as the absence of detectable erythrocytic form parasites) (P = 0.007, chi square) and

97 to the liver where they develop into the exo-erythrocytic forms (EEFs).

98 inst both pathogenic and transmissible intra-erythrocytic forms of the malaria parasite Plasmodium fa

99 ugs active against both erythrocytic and exo-erythrocytic forms would be preferable.

100 esearchers to investigate the biology of exo-erythrocytic forms.

101 oms, the development and maturation of intra-erythrocytic gametocytes that are transmissible to Anoph

102 and 2) compounds with antioxidant activity, erythrocytic glutathione, plasma glutathione peroxidase,

103 efficiency within the time-span of a single erythrocytic growth cycle.

104 cule, ACT-213615, potently inhibits in vitro erythrocytic growth of all tested Plasmodium falciparum

105 sickle cell disease, deoxygenation of intra-erythrocytic hemoglobin S leads to hemoglobin polymeriza

106 In hypoxia, erythrocytic hemoglobin tetramers produce nitric oxide t

107 iron protoporphyrin IX (FePPIX) derived from erythrocytic hemoglobin.

108 eleased during the proteolytic catabolism of erythrocytic hemoglobin.

109 is proposed as an important component of pre-erythrocytic human malaria vaccines.

110 um falciparum (Pf) infection mediated by pre-erythrocytic immunity can be experimentally induced unde

111 nder chloroquine cover does not generate pre-erythrocytic immunity, which is acquired only after immu

112 ytotoxic CD4 and CD8 T-cell responses in pre-erythrocytic immunity.

113 linositol-anchored proteins had no effect on erythrocytic infection by malarial parasite or movement

114 Thus, erythrocytic infection does not preclude the establishme

115 he effects of sporozoite-specific Abs on pre-erythrocytic infection in vivo remain underdeveloped.

116 knockout mice are unable to clear a primary erythrocytic infection of Plasmodium chabaudi chabaudi.

117 development of memory T cells during active erythrocytic infection remains uncharacterized.

118 t this complex with a goal of preventing the erythrocytic invasion of these parasites and to further

119 rtant roles during the Plasmodium falciparum erythrocytic life cycle.

120 ith recognition of antigens expressed in pre-erythrocytic life-cycle stages.

121 erentially expressed over the parasite intra-erythrocytic lifecycle, and applied it to samples from p

122 e commitment of blood progenitors toward the erythrocytic lineage and link Notch signaling to optimal

123 n of human progenitor cells into colonies of erythrocytic lineage.

124 th bone marrow failure, affecting mostly the erythrocytic lineage.

125 ed in heme biosynthesis, specifically in the erythrocytic lineage.

126 teworthy was the 40% decline in cells of the erythrocytic lineages in the marrow of colitis mice, whi

127 host is thought to be restricted to the pre-erythrocytic liver phase.

128 vaccinia Ankara (MVA) vectors expressing pre-erythrocytic malaria Ags.

129 specific T-cell responses in humans to a pre-erythrocytic malaria antigen, thrombospondin-related adh

130 CD25 lead to improved protection against pre-erythrocytic malaria challenge.

131 Erythrocytic malaria parasites degrade hemoglobin as a s

132 Erythrocytic malaria parasites degrade hemoglobin in an

133 idic food vacuole to provide amino acids for erythrocytic malaria parasites.

134 Vaccination with the pre-erythrocytic malaria vaccine RTS,S induces high levels o

135 has made it the leading candidate for a pre-erythrocytic malaria vaccine.

136 dies suggested that yd2 T cells help control erythrocytic malaria, whether yd2 T cells recognize infe

137 hopoiesis, including a 2- 3-fold increase in erythrocytic markers.

138 During intra-erythrocytic maturation, the infected erythrocyte (iE) m

139 Erythrocytic mechanisms involved in malarial infection a

140 initially acquired free cholesterol or inner erythrocytic membrane-derived cholesterol, we observed b

141 aches the spectrin/actin cytoskeleton to the erythrocytic membrane.

142 y interacting with both the surface of intra-erythrocytic merozoites and the inner aspect of erythroc

143 nt, including maturation into infectious exo-erythrocytic merozoites as well as the formation and per

144 ements and provide evidence that hepatic and erythrocytic merozoites differ.

145 e e1alpha(-) and e3(-) parasites to form exo-erythrocytic merozoites during late liver stage developm

146 e1 alpha(-) and e3(-) parasites to form exo-erythrocytic merozoites during late liver stage developm

147 entify a subset of HbSS patients with higher erythrocytic miR-144 expression and more severe anemia.

148 work we determined whether the primary human erythrocytic nitrite reductase is hemoglobin as opposed

149 suggest that deoxyhemoglobin is the primary erythrocytic nitrite reductase operating under physiolog

150 otal NO-related signal in blood is caused by erythrocytic nitrite, which may partly be bound to hemog

151 e effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes p

152 A variety of defects in either the erythrocytic or microsomal forms of the enzyme have been

153 assified variants as implicated in glycemic, erythrocytic, or unclassified biology and tested whether

154 rom the fetal state, characterized by robust erythrocytic output that supports prenatal growth in the

155 killed multidrug-resistant strains of intra-erythrocytic P. falciparum parasites at sub to low micro

156 here the essential function of pfht for the erythrocytic parasite growth as it was not possible to k

157 th cell-mediated and humoral immunity to pre-erythrocytic parasite stages can provide protection agai

158 has been traditionally focused on targeting erythrocytic parasite stages that cause clinical symptom

159 ually and very rapidly affects all 3 asexual erythrocytic parasite stages.

160 and is located on the membrane of the intra-erythrocytic parasite's digestive vacuole.

161 e by demonstrating their expression in intra-erythrocytic parasites along with their interactions wit

162 unity, in addition to protection against pre-erythrocytic parasites following high dose sporozoite im

163 Accumulation of erythrocytic parasites in bone marrow and the spleen has

164 All intra-erythrocytic parasites were susceptible, but schizonts w

165 ed by inoculating humans with irradiated pre-erythrocytic parasites, and a recombinant pre-erythrocyt

166 te that although falcipain-1 is expressed by erythrocytic parasites, it is not essential for normal d

167 tter characterize the role of falcipain-1 in erythrocytic parasites, we disrupted the falcipain-1 gen

168 bition of host haemoglobin uptake into intra-erythrocytic parasites.

169 transition from the pre-erythrocytic to the erythrocytic part of the life cycle.

170 ionary pressure of endemic malaria and other erythrocytic pathogens has shaped variation in genes enc

171 RTS,S targets the pre-erythrocytic phase of the disease and induces high antib

172 develops as wild type throughout the asexual erythrocytic phase of the life cycle.

173 During the erythrocytic phase of the parasite life cycle, Plasmodiu

174 malarials, ART, and artesunate to subdue the erythrocytic phase of the parasite life cycle.

175 malarials, ART, and artesunate to subdue the erythrocytic phase of the parasite life cycle.

176 eine protease and important hemoglobinase of erythrocytic Plasmodium falciparum parasites.

177 Erythrocytic Plasmodium parasite forms refractory to enr

178 le antiplasmodial activities against asexual erythrocytic Plasmodium parasites, with improved safety

179 ive efficacy after oral administration in an erythrocytic Plasmodium yoelii murine malaria model; (3)

180 nd significantly greater proliferation of an erythrocytic progenitor cell line compared with stromal

181 h PKA activity was known to be necessary for erythrocytic proliferation, we show that uncontrolled in

182 A drug for causal (ie, pre-erythrocytic) prophylaxis of Plasmodium falciparum malar

183 lations as essential for vaccine-induced pre-erythrocytic protection against malaria, a finding that

184 on induces stage-specific and long-lived pre-erythrocytic protective anti-malarial immunity, mediated

185 reductase is hemoglobin as opposed to other erythrocytic proteins that have been suggested to be the

186 the respective contributions of hepatic and erythrocytic protoporphyrin to the pathophysiology of EP

187 Babesia spp. are tick-transmitted intra-erythrocytic protozoan parasites that infect humans and

188 Hepatocystis parasites lack the intermittent erythrocytic replication cycles, the signature and exclu

189 et, SGLT2 inhibitors produce an unattenuated erythrocytic response in these patients.

190 based on our RhCG structure suggest that the erythrocytic Rh complex is composed of stochastically as

191 nitroso-N-acetylcysteine (SNOAC), decreasing erythrocytic S-nitrosothiol content, both during whole-b

192 36 parasite kinases as likely essential for erythrocytic schizogony.

193 ality of the orthologous gene for P. berghei erythrocytic schizogony.

194 to humans with sickle cell disease in having erythrocytic sickling, vascular ectasia, intravascular h

195 The elevated levels of intra-erythrocytic SNO-Hb fell rapidly, independent of oxygen

196 exhibited selective activity towards the pre-erythrocytic stage (98% of activity against P. gallinace

197 gene is expressed specifically in the sexual erythrocytic stage (gametocytes).

198 e known to be causal prophylactic and potent erythrocytic stage agents in avian models.

199 Vaccines targeting the erythrocytic stage are often viewed as an anti-disease s

200 s and protective capacities against a lethal erythrocytic stage challenge, than those resulting from

201 by a vaccine against the liver stage, a pre-erythrocytic stage during which the parasite multiplies

202 P. falciparum erythrocytic stage growth in vitro is reduced in anaemic

203 completely protected against development of erythrocytic stage infection after sporozoite challenge.

204 known about protective immunity against pre-erythrocytic stage malaria by considering the humoral an

205 itro correlate of protective immunity to exo-erythrocytic stage malaria vaccines.

206 r developing protective immunity against pre-erythrocytic stage malaria.

207 ypeptides designated MSP1a and MSP1b) of the erythrocytic stage of Anaplasma marginale conferred prot

208 fA-M1 and PfA-M17, play crucial roles in the erythrocytic stage of infection and have been validated

209 During the erythrocytic stage of its life cycle, the human malaria

210 emonstrated a rapid rate of clearance of the erythrocytic stage of P. falciparum in the SCID mouse mo

211 serine hydrolase superfamily in the asexual erythrocytic stage of P. falciparum.

212 lkylate protein target(s) within the asexual erythrocytic stage of Plasmodium falciparum (3D7).

213 rticle vaccine, RTS,S, which targets the pre-erythrocytic stage of Plasmodium falciparum infection.

214 e of a protective effect against the asexual erythrocytic stage of the life cycle.

215 ve long-lived sterile immunity targeting pre-erythrocytic stage parasites in mice.

216 on the surface of P. knowlesi sporozoite and erythrocytic stage parasites.

217 es of whole blood and spleen over 12 days of erythrocytic stage Plasmodium chabaudi infection in C57B

218 ranted for tests in clinical trials as a pre-erythrocytic stage vaccine candidate.

219 Of the erythrocytic stage vaccine candidates, the 19 kDa fragme

220 A highly efficacious pre-erythrocytic stage vaccine would be an important tool fo

221 arum circumsporozoite (CS) protein-based pre-erythrocytic stage vaccine, RTS,S, induces a high level

222 ctive targets in the effort to develop a pre-erythrocytic stage vaccine.

223 culture-derived A. marginale and the bovine erythrocytic stage, currently the source of A. marginale

224 st time on malaria parasites for analysis of erythrocytic stage-specific gene expression.

225 ental phase in the liver, which precedes the erythrocytic stage.

226 ites and around the rhoptries in the asexual erythrocytic stage.

227 promise as a component of a vaccine against erythrocytic-stage falciparum malaria.

228 uced significant protective efficacy against erythrocytic-stage infection in a pre-specified primary

229 nging them with homologous P. falciparum FVO erythrocytic-stage malaria parasites.

230 candidates that target infection by asexual erythrocytic-stage malaria parasites.

231 rovide the foundation for an approach to pre-erythrocytic-stage malaria vaccine development, based on

232 Deltamif parasites grew normally as asexual erythrocytic-stage parasites and showed normal infection

233 ues infected by intravenous inoculation with erythrocytic-stage parasites did not display these same

234 cted with iPfSPZ produced asexual and sexual erythrocytic-stage parasites in culture, and gametocytes

235 early blood responses in mice infected with erythrocytic-stage Plasmodium chabaudi.

236 s may represent an in vitro correlate of pre-erythrocytic-stage protective immunity.

237 g two preerythrocytic-stage proteins and two erythrocytic-stage proteins from P. knowlesi and combina

238 f sporozoites and is the leading malaria pre-erythrocytic-stage vaccine candidate.

239 Data nevertheless suggest that a pre-erythrocytic-stage vaccine should be designed to induce

240 nce of CSP in protection against malaria pre-erythrocytic stages and demonstrate that a significant p

241 hoproteomic studies in Plasmodium falciparum erythrocytic stages and Plasmodium berghei ookinetes hav

242 nd protein synthetic capabilities of asexual erythrocytic stages and sexual stages of P. falciparum.

243 hese, 19 induced antibody titers against the erythrocytic stages and three against sporozoite stages.

244 otective immune responses that eliminate pre-erythrocytic stages are paving the way for the developme

245 site that infects human erythrocytes and the erythrocytic stages are responsible for all symptoms and

246 e effect seen on parasite development in the erythrocytic stages is potent.

247 rasite that target the clinically silent pre-erythrocytic stages of infection have emerged as one of

248 ive stress to which it is exposed during the erythrocytic stages of its life cycle.

249 work on protective immunity against the pre-erythrocytic stages of malaria has focused on induction

250 ajor role in protective immunity against pre-erythrocytic stages of malaria parasites.

251 (MSP-1), a leading vaccine candidate against erythrocytic stages of malaria, was expressed as a fusio

252 1H)-quinolones with nanomolar EC(50) against erythrocytic stages of multidrug resistant W2 and TM90-C

253 vitro activity against both the hepatic and erythrocytic stages of P. berghei and P. falciparum infe

254 uences fused to green fluorescent protein in erythrocytic stages of P. falciparum and by immunofluore

255 chondrial electron transport nonessential in erythrocytic stages of P. falciparum.

256 sulfadoxine/pyrimethamine (S/P) to clear the erythrocytic stages of P. vivax in vivo.

257 The intra-erythrocytic stages of Plasmodium falciparum assemble a

258 protocol for the in vitro cultivation of the erythrocytic stages of Plasmodium falciparum revolutioni

259 RTS,S/AS01, a vaccine targeting pre-erythrocytic stages of Plasmodium falciparum, is undergo

260 cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium.

261 Here we show that erythrocytic stages of the human malaria parasite Plasmo

262 inhibitors (PIs) exert inhibitory effects on erythrocytic stages of the human-malaria parasite Plasmo

263 roteins expressed during exoerythrocytic and erythrocytic stages of the life cycle to test the hypoth

264 Erythrocytic stages of the malaria parasite Plasmodium f

265 volved in generating immune responses to the erythrocytic stages of the malaria parasite, Plasmodium,

266 Vaccines targeting the pre-erythrocytic stages of the P. falciparum life cycle are

267 essed in the sporozoite, asexual, and sexual erythrocytic stages of the parasite life cycle.

268 rasite Plasmodium falciparum in vitro and on erythrocytic stages of the rodent-malaria parasite Plasm

269 as been drawn to the mosquito stages and pre-erythrocytic stages owing to recognition that these are

270 otection is mediated by immunity against pre-erythrocytic stages, presumably at least partially by cy

271 iparum parasites in the pre-erythrocytic and erythrocytic stages, with some research on transmission-

272 etween Toxoplasma tachyzoites and Plasmodium erythrocytic stages.

273 sential role of the apicoplast in Plasmodium erythrocytic stages.

274 e that targets both the exo-erythrocytic and erythrocytic stages.

275 dy and CD4+ T cells to target Plasmodium pre-erythrocytic stages.

276 reen fluorescent protein fusions in parasite erythrocytic stages.

277 are expressed in sporozoites and hepatic and erythrocytic stages.

278 ve been concerned with asexual and/or sexual erythrocytic stages.

279 the comprehensive transcriptional profile of erythrocytic stages.

280 es induce cross-stage immunity targeting pre-erythrocytic stages.

281 bs were devoid of actin, but proteins of the erythrocytic submembranous cytoskeleton were present.

282 stages, marking the transition from the pre-erythrocytic to the erythrocytic part of the life cycle.

283 ultiethnic cohorts with HbA1c, glycemic, and erythrocytic traits are required to better determine the

284 us merozoites to identify stage-specific pre-erythrocytic transcripts.

285 ovide a physiologically robust mechanism for erythrocytic transport of NO bioactivity allowing for ho

286 as a fusion protein, thereby acting as a pre-erythrocytic vaccine and a TB vaccine, respectively.

287 The leading pre-erythrocytic vaccine candidate is RTS,S, and early resul

288 However, experimental evidence, from pre-erythrocytic vaccine candidates and irradiated sporozoit

289 Numerous pre-erythrocytic and erythrocytic vaccine candidates have been evaluated safe

290 A major target of a pre-erythrocytic vaccine is the P. vivax circumsporozoite pr

291 rythrocytic parasites, and a recombinant pre-erythrocytic vaccine partially protects humans from infe

292 We envision that a highly protective pre-erythrocytic vaccine will likely be based upon a heterol

293 vo protective activity and indicate that pre-erythrocytic vaccines against Plasmodium should include

294 e a novel approach in designing CS based pre-erythrocytic vaccines against Plasmodium using the adjuv

295 nd tested whether additive genetic scores of erythrocytic variants (GS-E) or glycemic variants (GS-G)

296 In Europeans and Asians, erythrocytic variants in aggregate had only modest effec

297 Nineteen glycemic and 22 erythrocytic variants were associated with HbA1c at geno

298 Although gametocytes are intra-erythrocytic when present in infected humans, developing

299 nized individuals react strongly against pre-erythrocytic while semi-immune individuals mainly react

300 rtantly, there is limited NO production from erythrocytic xanthine oxidoreductase and nitric-oxide sy