ライフサイエンスコーパス: erythropoietin receptor

1 h altered signaling events downstream of the erythropoietin receptor.

2 ivated JAK2 to induce phosphorylation of the erythropoietin receptor.

3 0(5) units/ml on cells that also express the erythropoietin receptor.

4 replaced with the cytoplasmic domain of the erythropoietin receptor.

5 lls engineered to coexpress Mpl receptor and erythropoietin receptor.

6 mutations of the SHP-1 binding domain of the erythropoietin receptor.

7 ge-restricted genes, including Klf1/Eklf and Erythropoietin receptor.

8 ed blood cells-that is caused by a truncated erythropoietin receptor.

9 ch as glucose and anion transporters and the erythropoietin receptor.

10 toward early differentiation with increased erythropoietin receptor.

11 lical dimerization motif found in the murine erythropoietin receptor.

12 tions between transferrin receptor-2 and the erythropoietin receptor.

13 gh its ability to transduce signals from the erythropoietin receptor.

14 his is similar to the K(d) of SOCS-3 for the erythropoietin receptor.

15 d virus envelope glycoprotein, gp55, and the erythropoietin receptor.

16 ytokine receptors such as growth hormone and erythropoietin receptors.

17 The precise role of erythropoietin receptor-activated (EpoR-activated) Stat5

18 Lack of erythropoietin receptor affects brain development as ear

19 high doses (50 mug/kg i.p.) of an exogenous erythropoietin receptor agonist in an inflammation-induc

20 ed whether a novel, synthetic, peptide-based erythropoietin-receptor agonist (Hematide, Affymax) can

21 treated them with a synthetic peptide-based erythropoietin-receptor agonist.

22 ther investigated in mice expressing minimal erythropoietin receptor alleles.

23 containing the intracellular portion of the erythropoietin receptor allowed cells normally dependent

24 FFV envelope glycoprotein interacts with the erythropoietin receptor and a short form of the receptor

25 as been proposed for the activation of human erythropoietin receptor and human growth hormone recepto

26 and negatively regulates signalling from the erythropoietin receptor and is likely to regulate other

27 , the thrombopoietin receptor (MPL), and the erythropoietin receptor and mutations of other genes inv

28 tracellular and transmembrane domains of the erythropoietin receptor and of the intracellular domain

29 ecies barrier exists between mouse and human erythropoietin receptor and that the human erythropoieti

30 hromosome 19p13.2/3, near genes encoding the erythropoietin receptor and the cytokine receptor-associ

31 trast to the acquired MPDs, mutations of the erythropoietin receptor and thrombopoietin receptor have

32 ociate with the IL-3 receptor beta chain and erythropoietin receptor and to inhibit signaling mediate

33 teraction of the viral protein gp55 with the erythropoietin receptor, and other host factors, drives

34 n receptor subunits, sucrase-isomaltase, the erythropoietin receptor, and two of the subunits of the

35 nic lethality in the erythropoietin(-/-) and erythropoietin receptor(-/-) animals.

36 mice, while it has no effect in hearts from erythropoietin receptor(-/-) animals.

37 of human erythroblasts with mouse antihuman erythropoietin receptor antibody but not mouse immunopur

38 Although high levels of erythropoietin receptor are produced in embryonic brain,

39 425 and 367 in the cytoplasmic domain of the erythropoietin receptor are required for the phosphoryla

40 -CSFR fused to the cytoplasmic domain of the erythropoietin receptor, are able to support the product

41 Specifically, an erythropoietin receptor-based dimerization assay was use

42 This novel agonist of the erythropoietin receptor can correct anemia in patients w

43 -9R alpha-chain, IL-2 receptor ss-chain, and erythropoietin receptor, can be polyubiquitinated and de

44 be immunoprecipitated by an antiserum to the erythropoietin receptor carboxyl-terminal domain.

45 2R beta with either gamma c or the truncated erythropoietin receptor chain led to an array of specifi

46 sion systems: 1) 32D cells expressing leptin/erythropoietin receptor chimeras, 2) COS-7 cells express

47 R) signaling complex by a severely truncated erythropoietin receptor cytoplasmic domain lacking tyros

48 We report that the erythropoietin receptor cytosolic juxtamembrane region i

49 extracellular ligand-binding domains of the erythropoietin receptor, determined at 1.9 A from two cr

50 ivation while preventing JAK2 V617F-promoted erythropoietin receptor dimerization.

51 al regulator of erythropoiesis, cell surface erythropoietin receptors dimerize and activate specific

52 n the extracellular dimerization site of the erythropoietin receptor, distant from the hormone bindin

53 In studies to identify the erythropoietin receptor domains required for activation

54 Erythropoietin(-/-) and erythropoietin receptor(-/-) embryos also suffered from

55 Both erythropoietin(-/-) and erythropoietin receptor(-/-) embryos suffered from ventr

56 Other modes of erythropoietin receptor (EPO-R) activation, such as inte

57 ning progressively truncated isoforms of the erythropoietin receptor (EPO-R) and determined the rate

58 d tyrosine phosphorylation of both c-kit and erythropoietin receptor (EPO-R) and significantly greate

59 Kit receptor tyrosine kinase and erythropoietin receptor (Epo-R) cooperate in regulating

60 Signaling through the erythropoietin receptor (EPO-R) is crucial for prolifera

61 Stimulation of the erythropoietin receptor (EPO-R) or the interleukin-2 rec

62 We previously found increased erythropoietin receptor (EPO-R) protein levels in vigoro

63 expression of erythroid genes including the erythropoietin receptor (EPO-R) that results in increase

64 e cytokine erythropoietin (EPO), its cognate erythropoietin receptor (EPO-R), and associated Janus ty

65 n vivo requires collaboration between c-Kit, erythropoietin receptor (Epo-R), and GATA-1.

66 93T cells heterologously expressing TRPC and erythropoietin receptor (Epo-R), Epo stimulated an incre

67 In the erythropoietin receptor (Epo-R), two such motifs (box1 a

68 Here we show that erythroid progenitors from erythropoietin receptor (Epo-R)-/- fetal livers, infecte

69 at bind to the extra-cellular portion of the erythropoietin receptor (EPO-R).

70 uracil-treated mice expressing a compromised erythropoietin receptor EPOR-HM allele.

71 rosine residue (pY) peptide derived from the erythropoietin receptor (EpoR pY429) binds to the N-SH2

72 To understand the role of erythropoietin receptor (EpoR) activation in erythroid d

73 Here we show that the erythropoietin receptor (EPOR) acts as a critical switch

74 protein, SFFV gp55, forms a complex with the erythropoietin receptor (EpoR) and a short form of the r

75 Endothelial cells express erythropoietin receptor (EpoR) and are responsive to ery

76 failing signal transduction at the homomeric erythropoietin receptor (EpoR) and at the heteromeric in

77 displays 100-fold increased affinity for the erythropoietin receptor (EPOR) and correspondingly eleva

78 Here, to clarify the functional role of the erythropoietin receptor (EpoR) and its downstream transc

79 Ba/F3 and B6SUtA cells transfected with the erythropoietin receptor (EpoR) and selected with erythro

80 ceptors with the extracellular domain of the erythropoietin receptor (EpoR) and the cytoplasmic domai

81 whether or not tyrosine residues within the erythropoietin receptor (EPOR) are essential for biologi

82 Here, we show that ubiquitination of the erythropoietin receptor (EpoR) at Lys(256) is necessary

83 a model involves mitogenic activation of the erythropoietin receptor (EpoR) by the virus env gene (F-

84 Inherited mutations in the erythropoietin receptor (EPOR) causing premature termina

85 2/p30) that are hyperphosphorylated in a DA3/erythropoietin receptor (EpoR) cell line that expresses

86 rythropoiesis, we investigated its action on erythropoietin receptor (EpoR) cellular dynamics.

87 lls, we employed a prolactin receptor (PrlR)/erythropoietin receptor (EpoR) chimera system, in which

88 The cytoplasmic domain of the erythropoietin receptor (EpoR) contains a membrane-dista

89 ane targeted chimeric protein containing the erythropoietin receptor (EpoR) cytoplasmic domain fused

90 Erythropoietin receptor (EpoR) dimerization is an import

91 n) scaffold, that can systematically control erythropoietin receptor (EpoR) dimerization orientation

92 e cytokine known to regulate erythropoiesis, erythropoietin receptor (EpoR) expression and associated

93 unoblotting and immunostaining have reported erythropoietin receptor (EpoR) expression in nonhematopo

94 In this issue of Blood, Li et al show that erythropoietin receptor (Epor) expression marks the cent

95 Western blotting was used to detect AT1R and erythropoietin receptor (EpoR) expression.

96 om the anemic strain (gp55-A), activates the erythropoietin receptor (EpoR) for proliferation of hema

97 tor receptor (fgfr-1), and downregulation of erythropoietin receptor (EpoR) gene expression.

98 any cancer cells show some expression of the erythropoietin receptor (EPOR) gene, although the "funct

99 utation affecting codon 399 in exon 8 of the erythropoietin receptor (EPOR) gene, encoding an EpoR pe

100 f red cell production through agonism of the erythropoietin receptor (EpoR) has historically been acc

101 able to bind to one of the 2 subunits of the erythropoietin receptor (EpoR) homodimer and is thus a c

102 Erythropoietin receptor (EpoR) homodimerization is an in

103 ated with mutations in the gene encoding the erythropoietin receptor (EpoR) in a small number of fami

104 O) is used to treat anemia by activating the erythropoietin receptor (EPOR) in erythroid progenitor c

105 To elucidate the role of Epo and erythropoietin receptor (EpoR) in melanoma, we examined

106 L traptamers) that specifically activate the erythropoietin receptor (EPOR) in mouse cells to confer

107 Ectopic expression of the erythropoietin receptor (EpoR) in the interleukin-3 (IL-

108 The erythropoietin receptor (EPOR) is a member of a family o

109 The erythropoietin receptor (EPOr) is activated by ligand-in

110 Signal transduction by the erythropoietin receptor (EPOR) is activated by ligand-me

111 Notably, we found that the erythropoietin receptor (EPOR) is consistently highly ex

112 The erythropoietin receptor (EpoR) is essential for erythrob

113 The erythropoietin receptor (EpoR) is essential for producti

114 Here, we show that erythropoietin receptor (EPOR) is hydroxylated on prolin

115 The erythropoietin receptor (EpoR) is required for the proli

116 Erythropoietin receptor (EPOR) is thought to be activate

117 We generated an erythropoietin receptor (EpoR) isoform (ER343/401-S3) th

118 Two distinct forms of the erythropoietin receptor (EPOR) mediate the cellular resp

119 Using myleoid cells expressing a series of erythropoietin receptor (EpoR) mutants, we have demonstr

120 (EPO) regulates erythropoiesis by binding to erythropoietin receptor (Epor) on erythroid progenitor c

121 The putative presence of the erythropoietin receptor (EpoR) on human cancer cells has

122 generate cells expressing high levels of the erythropoietin receptor (EpoR) or a dominant negative Sm

123 Mutagenesis of the erythropoietin receptor (EPOR) permits analysis of the c

124 In contrast, the erythropoietin receptor (EpoR) requires only one recepto

125 tions of the cytoplasmic domain of the human erythropoietin receptor (EPOR) result in a dominantly in

126 tial for normal red cell development and for erythropoietin receptor (EpoR) signaling.

127 design of de novo TM proteins targeting the erythropoietin receptor (EpoR) TM domain in a custom bin

128 und and unbound forms, the activation of the erythropoietin receptor (EPOR) was initially proposed to

129 We found that the 78-kDa erythropoietin receptor (EPOR), a highly modified form o

130 oprotein, gp55, constitutively activates the erythropoietin receptor (EPOR), causing uncontrolled ery

131 Ab12.6, an agonistic human Ab targeting the erythropoietin receptor (EPOR), exhibits several potenti

132 ate receptors, prolactin receptor (PrlR) and erythropoietin receptor (EpoR), respectively.

133 a homodimeric Type I cytokine receptor, the erythropoietin receptor (EpoR), the thrombopoietin recep

134 sly characterized a truncation mutant of the erythropoietin receptor (EpoR), which is associated with

135 erythroid-specific gene expression including erythropoietin receptor (EpoR), which suggests a novel m

136 Spry1 was discovered to be regulated via the erythropoietin receptor (EPOR), with marked EPO-induced

137 served in the content of beta-globin mRNA in erythropoietin receptor (EpoR)-transfected Ba/F3 cells b

138 ony-stimulating factor receptor (G-CSFR) and erythropoietin receptor (EPOR).

139 d with a growth factor receptor, such as the erythropoietin receptor (EpoR).

140 t studies indicate that cancer cells express erythropoietin receptor (EpoR).

141 n (Epo) can generate commitment cues via the erythropoietin receptor (EpoR); specifically, EpoR signa

142 ates growth hormone receptor (GHR-pY595) and erythropoietin receptor (EpoR-pY426) at 1.98 angstrom an

143 agents (ESAs) have been reported to activate erythropoietin receptors (EpoR) on cell types, including

144 n apparent Mr of 55,000 (gp55) that binds to erythropoietin receptors (EpoR) to stimulate erythroblas

145 ein with apparent Mr of 55,000 that binds to erythropoietin receptors (EpoR) to stimulate erythroblas

146 n specifically binds to and activates murine erythropoietin receptors (EpoRs) coexpressed in the same

147 by binding and orientating two cell-surface erythropoietin receptors (EPORs) which trigger an intrac

148 Mice lacking the erythropoietin receptor exhibit severe anaemia and defec

149 Mice lacking the erythropoietin receptor exhibit severe anemia and die at

150 Erythropoietin receptors expressed in Sf9 cells were ins

151 When we induced Jak2V617F expression in erythropoietin receptor expressing precursor cells, the

152 Erythropoietin receptor expression in nonhematopoietic t

153 In summary, enhanced erythropoietin receptor expression promotes transplanted

154 Here, we report that enhanced erythropoietin receptor expression, as well as exogenous

155 poietin expression and a tenfold increase in erythropoietin receptor expression, increased cell survi

156 but these cells required coexpression of the erythropoietin receptor for optimal signaling.

157 escribe four different rearrangements of the erythropoietin receptor gene EPOR in Philadelphia chromo

158 Thus, the truncated erythropoietin receptor gene shows promise as a means fo

159 vates the 3 main myeloid cytokine receptors (erythropoietin receptor, granulocyte colony-stimulating

160 Mutation of the erythropoietin receptor has been demonstrated to cause f

161 ermal growth factor receptor (ErbB1) and the erythropoietin receptor have indicated that interactions

162 lls, retroviral vectors containing the human erythropoietin receptor (hEpoR) gene were used to transd

163 d property of all EMAs, to bind on the human erythropoietin receptor (hEPOR), is therefore exploited.

164 For a hypomorphic erythropoietin receptor-HM allele, major defects in eryt

165 Our labs recently engineered novel erythropoietin receptor-IFN chimeric receptors, and we h

166 onstrated a novel role of erythropoietin and erythropoietin receptor in cardiac development in vivo.

167 ty, and when overexpressed together with the erythropoietin receptor in cells, it caused hyperactivat

168 t-derived growth factor beta receptor or the erythropoietin receptor in cultured mouse cells, resulti

169 regulation in the liver and associates with erythropoietin receptor in erythroid cells.

170 Expression of a truncated erythropoietin receptor in hematopoietic stem cells has

171 compounds that can cause dimerization of the erythropoietin receptor in solution.

172 Analysis of the distribution of erythropoietin receptors in Sf9 plasma membrane and cyto

173 basic science studies on erythropoietin and erythropoietin receptors in solid cancers, raise concern

174 Solubilized erythropoietin receptors in whole-cell lysates and isola

175 totic pathways, potentially activated by the erythropoietin receptor, interact to produce the remarka

176 The spectrum of progenitors targeted by the erythropoietin receptor is broader during stress than du

177 Activation of the erythropoietin receptor is essential for the survival, p

178 We found that erythropoietin receptor is expressed in the developing m

179 SPCs) can recreate the truncated form of the erythropoietin receptor, leading to substantial increase

180 f Tyr(985) does not alter STAT3 signaling by erythropoietin receptor-LRb (ELR) chimeras in transfecte

181 te is regulated at least in part through the erythropoietin receptor-mediated survival of splenic ear

182 in of SHP-1 with the tyrosine phosphorylated erythropoietin receptor modestly potentiated but was not

183 Erythropoietin(-/-) and erythropoietin receptor(-/-) mouse embryos die around em

184 and beta common (beta c), whereas the normal erythropoietin receptor (nEpoR) comprises only one known

185 oetal liver, endocardium and myocardium, the erythropoietin receptor null mouse shows extensive apopt

186 esis and other organ defects observed in the erythropoietin receptor null mouse.

187 osis in fetal liver, heart, and brain in the erythropoietin receptor null phenotype was markedly redu

188 iously demonstrated expression of endogenous erythropoietin receptor on murine myoblasts, and erythro

189 Erythropoietin induces dimerization of the erythropoietin receptor on the surface of erythroid prog

190 ve agent that does not bind to the classical erythropoietin receptor or affect hematocrit.

191 cal and suggests that studying modulation of erythropoietin receptor pathway may lead to strategies i

192 een focus forming virus, which activates the erythropoietin receptor; polyoma virus middle T antigen,

193 Erythropoietin receptors produced in Sf9 cells could be

194 Possible erythropoietin/erythropoietin receptor proerythroblast stage specific e

195 Erythropoietin receptor protein production was maximal 4

196 Mice with erythropoietin receptor restricted to hematopoietic tiss

197 of C2C12 myoblasts overexpressing truncated erythropoietin receptor showed more transplanted cell in

198 system restores active hematopoiesis via the erythropoietin receptor/signal transducer and activator

199 During stress, erythropoietin receptor signaling downregulates erythrob

200 However, erythropoietin receptor signaling has been mostly studie

201 kemia cell lines and enhances ligand-induced erythropoietin receptor signaling in erythroid progenito

202 ment with lenalidomide (LEN), which augments erythropoietin receptor signaling in vitro, can restore

203 Further, the requirement for erythropoietin receptor signaling is more stringent duri

204 This work reveals that erythropoietin receptor/Stat5 pathway contributes to BMM

205 Animals expressing only the human erythropoietin receptor survived through adulthood with

206 port the design and validation of two mutant erythropoietin receptors that probe the role of individu

207 se coding for alpha-globin, beta-globin, the erythropoietin receptor, the erythroid krupple-like fact

208 e kinases activated during engagement of the erythropoietin receptor, the Janus family kinase Jak-2 a

209 everal type I cytokine receptors, namely the erythropoietin receptor, the thrombopoietin receptor (Tp

210 trates of these kinases are tyrosines in the erythropoietin receptors themselves and the signal trans

211 iation (erythropoiesis), and truncated human erythropoietin receptors (thEpoR) have been reported in

212 cades are activated during engagement of the erythropoietin receptor to mediate the biological effect

213 ered to be refractory (the IL-6, leptin, and erythropoietin receptors), to suppressor of cytokine sig

214 revious study, it was found that a truncated erythropoietin receptor transgene (tEpoR tg) enables mul

215 n erythropoietin receptor and that the human erythropoietin receptor transgene is able to provide spe

216 This phenotype can be rescued by the human erythropoietin receptor transgene.

217 c defect associated with embryos lacking the erythropoietin receptor was corrected and the increased

218 The full-length murine erythropoietin receptor was expressed in Spodoptera frug

219 these same samples, erythroid-specific mRNA (erythropoietin receptor) was also detected.

220 dentification of compounds that can dimerize erythropoietin receptor, we have developed a novel, high

221 corresponding to the extracellular domain of erythropoietin receptor were expressed in Escherichia co

222 teracting residues in the growth hormone and erythropoietin receptors, whereas Cys-161, Cys-210, and

223 Transplantation of a region from the erythropoietin receptor, which contains a docking site f

224 of 100 mutants within the WSXWS motif of the erythropoietin receptor, which represents all single ami

225 ng the expression of the cDNA of a truncated erythropoietin receptor with a previously reported genom