ライフサイエンスコーパス: escape

1 l mutations reveal a 'pyridine-assisted cube escape'.

2 ion, consistent with degradation escape (NMD-escape).

3 from infected conspecifics (social migratory escape).

4 an immunogenic region associated with viral escape.

5 radiosensitization and prevented metastatic escape.

6 inds PS-ASOs and facilitates their vesicular escape.

7 idgut provide a mechanism for enhanced virus escape.

8 he influence of peptide design for endosomal escape.

9 form in which to intervene to prevent immune escape.

10 only establish after the evolution of immune escape.

11 during this outbreak contributed to vaccine escape.

12 intracellular re-distribution and endosomal escape.

13 w as 0.058 ng/ml) and may prevent mutational escape.

14 evolve an ingenious scheme for survival and escape.

15 ere associated with antibody recognition and escape.

16 mutagenesis that enables stress tolerance or escape.

17 gratory recovery than under social migratory escape.

18 the evolution of cancer cells toward immune escape(1-5).

19 us pyogenes also hijack lymphatic vessels to escape a local infection site, transiting through sequen

20 metamaterials with emergent properties that escape a standard group theory analysis.

21 vershoots and oscillations, that have so far escaped a common, principled theoretical account.

22 In contrast, their lifetimes have so far escaped a similarly comprehensive understanding.

23 olecular basis by which a nonenveloped virus escapes a host membrane during infectious entry.IMPORTAN

24 coupled sensory network may facilitate rapid escape activation by enhancing the amplitude of giant ax

25 ursuit task in which prey follow intelligent escape algorithms.

26 s, resulting in loss of neutralization; such escape also occurred with combinations of antibodies bin

27 s affect an individual's ability to avoid or escape an attack by an ambush predator.

28 HIV diversification facilitates immune escape and complicates antiretroviral therapy.

29 membranes, histidine to facilitate endosomal escape and cysteine for stability and controlled cargo r

30 iction to transcription initiation, promoter escape and early elongation activities of Pol II.

31 urs, suboptimal persistence in vivo, antigen escape and heterogeneity, and manufacturing issues.

32 Only those exhibiting early endosomal escape and high pH of fusion were inhibited via a reduct

33 um with BAPTA-AM attenuated Tat endolysosome escape and LTR transactivation.

34 h rates of ~0.2 ps(-1), thus inhibiting cage escape and photoproduct formation.

35 he cocktail demonstrated resistance to virus escape and protected non-human primates (NHPs) against E

36 social development: how to improve the fire escape and rescue capacity remains a huge challenge.

37 rborization and sensory function to regulate escape and social behavior.

38 ed from TPCs is involved in Tat endolysosome escape and subsequent LTR transactivation.

39 e involvement of calcium in Tat endolysosome escape and subsequent LTR transactivation.

40 directly and indirectly to both tumor immune escape and the metastatic cascade.

41 r associate electrostatic charge with immune escape and viral evolutionary dynamics.

42 st the survival value of the M cell-mediated escapes and to show that the absence of this giant neuro

43 tion pathway: vaccine uptake, phagolysosomal escape, and epitope release.

44 Therefore, LNP uptake, endosomal escape, and mRNA translation with and without TLR4 activ

45 romotes high-titer viral replication, immune escape, and pathogenicity.

46 uble-hit treatment that allows iNKT cells to escape anergy and exert beneficial effects in biphasic s

47 riptional program employed by tumor cells to escape apoptosis, hence developing more aggressive and m

48 The behavioral principles of escape are evolutionarily conserved and rely on elementa

49 n factors; and novel factors that previously escaped attention.

50 The flexible escape behavior exhibited by C. elegans in response to t

51 visual motion-detection circuits and related escape behavior in the tractable locust system.

52 the literature concerning stimuli that evoke escape behavior, and we expect this tool will help recon

53 ing regulates multiple phenotypes, including escape behavior, associative learning, immunity and long

54 pr4), we show that pr1 cells regulate larval escape behavior.

55 e we show that that the lPBN is required for escape behaviors and aversive learning to noxious stimul

56 ent with examples of shell shapes that allow escape behaviors being mechanically weaker than those wh

57 , whereas dark stimuli activate SC and drive escape behaviors, suggesting that vLGN enables rapid mov

58 or lateral periaqueductal gray (lPAG) drives escape behaviors, whereas activation of lPBN efferents t

59 stem of giant axons and unique fast swimming/escape behaviors.

60 , exhibited a significant (125%) increase in escape behaviour for surveys at 91 m.

61 ling bias for Gq/11 signaling pathways while escaping beta-arrestin-mediated downregulation.

62 he largest pores, which would facilitate its escape, but instead occupies smaller pores or is present

63 ted within populations with social migratory escape, but never with migratory recovery.

64 Many tumours, however, escape by activating cellular pathways that lead to immu

65 cing ARCP-1 or PDE-1 activity promotes CO(2) escape by altering neuropeptide expression in the BAG CO

66 mimic HIV-1 target cells could prevent viral escape by exposing a universal vulnerability of HIV-1: t

67 pressor cells (G-MDSCs) that mediated immune escape by impairing T cell response.

68 tars were killed, whereas most fifth instars escaped by thrashing or dropping.

69 eliminate all rapid escapes, suggesting that escapes can equally well be driven by smaller neurons.

70 Here, we demonstrate that the escape circuit of the mud worm, Lumbriculus variegatus,

71 The interneurons associated with rapid escape circuits are adapted for fast pathway activation

72 ration and migration, enabled fibroblasts to escape contact inhibition, and transformed immortalized

73 lowing rapid evolution of mutant phages that escape CRISPR pressure.

74 of peptidergic neurons for executing binary escape decisions.

75 pathway, we hypothesise that some fs-indels escape degradation and elicit anti-tumor immune response

76 xtracellular boundaries, whereas single-cell escape depended on locally free tissue space.

77 itutive activity, but how the receptor could escape desensitization is unknown.

78 Gametocytes often escape detection even by molecular methods, therefore ul

79 Investigating the ability of HIV to escape different selection forces has generally relied o

80 their ability to undergo amitotic budding to escape dormancy.

81 This is counter-intuitive, since immune escape due to increased avidity (due itself to an increa

82 entrapped cargo, however, can have very low escape efficiency, with protein degradation occurring in

83 wever, the underlying mechanisms whereby Tat escapes endolysosomes remain unclear.

84 h Mediator components, enables our models to escape equilibrium bounds and access optimal regulatory

85 dges of the Rivera and Atlantic slabs, while escape flows are inferred through slab windows beneath P

86 We consider escape from a metastable state of a nonlinear oscillator

87 at expansion rates that give ample chance to escape from a sea lion-sized predator, but humpback whal

88 We studied "strand escape from an [n]-rung ladder" as an example of a dynam

89 insight into the potential for SARS-CoV-2 to escape from antibodies elicited during infection or deli

90 d/or reported epitopes associated with virus escape from antibody neutralization.

91 , suggesting that this drift may not lead to escape from antibody-mediated protection.IMPORTANCE Unde

92 pe from neutralization but did not result in escape from binding.

93 urdens within host populations via migratory escape from contaminated habitats and transmission hotsp

94 Carcinogen-induced apoptosis may trigger escape from dormancy of microtumors by interfering with

95 vaccine formulation to keep pace with viral escape from herd immunity.

96 hosts, Lyme borreliae require the ability to escape from host defense mechanisms, in particular compl

97 ; however, the virus continues to evolve and escape from host immune response through mutation and in

98 ronment, genetic alterations that facilitate escape from immune attack, and sensitivity to PD-1 block

99 IV-1 infection, rapid viral evolution allows escape from immune responses.

100 volution of migratory behaviour, rather than escape from infected conspecifics (social migratory esca

101 hat contribute to phenotypes associated with escape from killing by CTLs.

102 e deep convection and contribute to hydrogen escape from Mars during global dust storms.

103 This implies that the potential for water to escape from Mars is higher than previously thought.

104 These antibodies could drive viral escape from neutralization but did not result in escape

105 1, and are therefore predicted to result in escape from nonsense-mediated mRNA decay.

106 f-propulsion helps the system stochastically escape from one basin and reach another to make transiti

107 TB) are the Mycobacterium tuberculosis (Mtb) escape from phagolysosomal destruction and limited drug

108 r (EsxA:B) and are crucial for mycobacterial escape from phagosomes and cytosolic translocation.

109 tep mutations and the ability for strains to escape from suboptimal local fitness maxima.

110 well-characterized pathway of adenocarcinoma escape from suppressive anticancer therapy.

111 al cells, including a potential mechanism of escape from the host immune system by the expression of

112 s exhibit restricted rates of entry into and escape from the microdomain as well as enhanced phospho-

113 Low cohesion allows molecules to escape from the original assemblies and exchange dynamic

114 al for the neutralization of two MAbs, while escape from the other two MAbs required a combination of

115 mediated by CheY3, is necessary for cells to escape from the porous biofilm matrix.

116 1) and they offer an account that aims "to escape from the social dimension" (sect.

117 Interestingly, escape from these MAbs led to numerous HA mutations with

118 ction of distinct viral lineages involved in escape from vaccine protection.

119 targeting universal influenza vaccines-viral escape from vaccine-induced stalk immunity.

120 setting, when individual anchovies initiated escape from virtually approaching whales, then used thes

121 L) but whether they confer neurovirulence or escape from virus-neutralizing antibody (nAb) in vivo is

122 onserved epitopes within the capsid protein, escape from which results in a significant reduction in

123 A significant number of X-linked genes escape from X chromosome inactivation and are associated

124 nderstanding the epigenetics associated with escape from X chromosome inactivation has potential for

125 for reduced DNA methylation associated with escape from X chromosome inactivation.

126 x houghtonii soon escaped from cultivation and quickly spread in many part

127 us entry.IMPORTANCE How a nonenveloped virus escapes from a host membrane to promote infection remain

128 light stimulation, a matter flux of Pt(2) L escaping from autolysosomes to nucleus was observed, whi

129 icted the relative escape success for impala escaping from cheetah in open savanna versus acacia thic

130 etase (AlaRS) and can form BMAA-tRNA(Ala) by escaping from the intrinsic AlaRS proofreading activity.

131 NMD-escape fs-indels represent an attractive target for biom

132 rentially methylated in both syndromes while escape gene promoters remain unchanged.

133 In TS, almost all differentially expressed escape genes are down-regulated but most differentially

134 In KS, differentially expressed escape genes are up-regulated while the majority of inac

135 erences in adipocyte biology and highlight X-escape genes as a critical component of female physiolog

136 located within the Golgi, where it allows ER-escaped glycoproteins to bypass the classical N-glycosyl

137 An actual survival value of M cell-mediated escapes has never been supported experimentally and abla

138 silent latency states in sensory neurons to escape host detection.

139 tensively studied, the mechanism of how LANA escapes host's immune surveillance is not fully understo

140 However, in many cases, it is unclear how escaping host spatial control benefits gut bacteria and

141 vasion mechanism used by Plasmodium vivax to escape humoral immunity targeting PvDBP, the key ligand

142 riods, we found no evidence that colony-wide escape (i.e., flight) behaviour increased during drone f

143 only hijack various epigenetic mechanisms to escape immune restriction.

144 ion reactivates immunity against tumors that escaped immune surveillance in approximately 30% of case

145 he virus population that persists during ART escapes immune control remains unknown.

146 ement fragments, we find that this cell also escapes immune surveillance by neighboring macrophages,

147 sistent global disease burden by evolving to escape immunity induced by prior infections and vaccinat

148 biosynthetic and bioenergetic demands while escaping immunosurveillance or therapeutic interventions

149 ty and antigenic mutations that allow immune escape impact influenza epidemic dynamics at the populat

150 mising treatment approach to prevent antigen escape in CAR-T cell therapy against MM, and the vertica

151 ercome one of these barriers, phagolysosomal escape in DCs.

152 associated with cancer immune control versus escape in mice.

153 op that contributes to a form of aldosterone escape in vivo.

154 Arising from glasshouse escapes in North America and the Netherlands, the invasi

155 nging social conditions (linked to migratory escape) in terms of infection-driven migration.

156 Some BAs (approximately 5%) escape into the colon, where gut commensal bacteria conv

157 commodity have occasionally been released or escaped into the wild, within the range of an allopatric

158 significant risk from only a few propagules escaping into the environment from this source, and we p

159 e that the afferent pathway for MGF-mediated escape is glutamatergic.

160 Brownian escape is key to a wealth of physico-chemical processes,

161 Escape is more likely toward lower barrier direction.

162 Escape is one of the most studied animal behaviors, and

163 We find that Orai1-SNPs escape late endosomes through endosomal pH regulation of

164 ant nontyphoidal invasive disease in Africa, escape MAIT cell recognition through overexpression of r

165 , some animals changed the gaits used during escape maneuvers, and/or recruited the 'sensory' legs fo

166 The complete escape maps predict which mutations are selected during

167 For MCC, one immune escape mechanism is insufficient for recognition by T ce

168 OPT-302 combination therapy may overcome an escape mechanism to VEGF-A suppression in the management

169 s with built-in cell targeting and endosomal escape mechanisms are attractive intracellular delivery

170 An in-depth understanding of immune escape mechanisms in cancer is likely to lead to innovat

171 n of immune-suppressive molecules similar to escape mechanisms seen in human cancer patients.

172 nt in neuro-oncology, and the elucidation of escape mechanisms that lead to treatment resistance is c

173 diction, and understanding and harnessing of escape mechanisms.

174 Of note, the serum escape mutant completely lost the ability to bind to hum

175 rther characterization of the neutralization escape mutant generated using this MAb showed that three

176 Epitope mapping of the neutralizing mAbs via escape mutant virus generation revealed a shared binding

177 We observed that each individual escape mutant virus was able to avoid neutralization by

178 Three of four escape mutant viruses had increased lethality in the DBA

179 ure on the HA stalk can lead to expansion of escape mutant viruses in study participants challenged w

180 To investigate the potential threat of serum escape mutant viruses to humans and poultry, the impact

181 inin interacting with the MAbs, we generated escape mutant viruses.

182 was His to Tyr at amino acid 44; additional escape mutants had a His-to-Arg mutation at amino acid 4

183 Seasonal vaccines are often ineffective and escape mutants have been reported to all treatments for

184 In vitro selection of antibody escape mutants revealed that 53C10 recognizes a novel no

185 hat aims to decrease the potential for virus escape mutants that might arise in response to selective

186 Escape mutants were not generated after treatment with a

187 gens might play a role in generating vaccine-escape mutants, while substitutions at positions S195D a

188 umventing or limiting the emergence of viral escape mutants.

189 ell response, with a>=50% loss defined as an escape mutation.

190 Therefore, complete escape-mutation maps enable rational design of antibody

191 NMD-escape mutations are additionally found to associate wit

192 These escape mutations are rare and drug-specific, and some co

193 vel measures, such as the time to detectable escape mutations in plasma and the rate these mutations

194 investigate the generation and selection of escape mutations within individual viral lineages at the

195 Furthermore, the progeny accumulated CRISPR escape mutations, allowing rapid evolution of mutant pha

196 esting they may not be easily susceptible to escape mutations, and exhibit a lower binding:neutralizi

197 d to hemagglutinins carrying combinations of escape mutations, we developed an exponential protein ba

198 ral effector functions or selected for viral escape mutations.

199 %) of T cell epitopes harbored no detectable escape mutations.

200 g to the same RBD surface but have different escape mutations.

201 rgeting the same surface often have distinct escape mutations.

202 Bacteria have evolved mechanisms to escape neutrophils, including the secretion of leucocidi

203 is incompletely understood how cancer cells escape NK cell surveillance.

204 e enriched in genomic positions predicted to escape NMD, and associated with higher protein expressio

205 tein expression, consistent with degradation escape (NMD-escape).

206 To escape noxious stimuli, such as parasitoid wasp attacks,

207 that RTN prevents membrane damage during ER escape of a misfolded proinsulin aggregate destined for

208 be suitably sealed with cement to hinder the escape of CO(2).

209 ture of DTTs; this constriction prevents the escape of energized gas from the siphon and allows the t

210 hances viral replication and promotes immune escape of HIV-infected cells but lacks intrinsic enzymat

211 cal process for photoexcited carriers is the escape of holes from trap states, which prolongs the app

212 mbrane integrity may be threatened during ER escape of large macromolecular protein complexes, the ac

213 ressors, including chemotherapy, facilitated escape of leukemia cells from targeted third-generation

214 attery cycling and successfully stopping the escape of oxygen from LiCoO(2) even when the cathode is

215 potentially dangerous effect of enabling the escape of self-reactive T cells.

216 w host factor called Ubqln4 that facilitates escape of SV40 from the ER into the cytosol, thereby pro

217 nts require stable encapsulation, that is no escape of the substrate into bulk solution during experi

218 sessed and their role in survival and immune escape of the tumor cells was determined.

219 0 emerging from the ER, thereby facilitating escape of the virus from the ER into the cytosol, which

220 urther disassembly allows sigma1 release and escape of transcriptionally active reovirus cores into t

221 distribution of defective provirus types and escaped or unrecognized epitopes similar to that of the

222 y orbits, including parabolic and hyperbolic escaping orbits, of the solar system without learning or

223 roducts of triacylglycerols were not able to escape out until emulsions were extremely oxidized.

224 ell lymphomas with an emphasis on the immune escape pathways orchestrated by these diseases.

225 pletely resistant to CD4-Ig, suggesting that escape pathways that confer resistance against conventio

226 imizes material memory effects and optimizes escape performance given physiological power limitations

227 primarily invades host macrophages, where it escapes phagosomes within a few hours and replicates in

228 ith beta-lactam drugs appear to prevent such escape phenotypes.

229 development pipeline to combat the potential escape plans of SARS-CoV-2, including somatic mutations

230 mmunity, we hypothesized that certain immune-escape polymorphisms may impair Nef's ability to antagon

231 allow the tail to separate and the animal to escape predation.

232 observations show that decisions to avoid or escape predators occur at different spatiotemporal scale

233 ly experienced when entering their burrow to escape predators.

234 havior, we developed a method for simulating escape probabilities when live prey interact with ballis

235 nce of obstacles; however, if detected, prey escape probability was dependent on both the abundance o

236 th respect to a gravitational field on total escape probability, but a significant effect of airway n

237 cks and that flying rapidly is effective for escaping pursuing predators in the wild, but we did not

238 lled flow policies, determine total particle escape rates and local particle deposition.

239 c optical tweezers and achieve a doubling of escape rates compared to unhindered Brownian motion.

240 overdamped dynamics, the achievable boost of escape rates is, in principle, unbounded so that the bar

241 er profiles result in significantly enhanced escape rates, in breach of the intuition relying on the

242 rived melanoma cells with silenced HLA-I APM escaped recognition by autologous CD8+ T cells.

243 They further enable the design of escape-resistant antibody cocktails-including cocktails

244 eurons increase their activity during active escape, responding to stress when flight is a viable opt

245 The escape response and rhythmic swimming in zebrafish are d

246 These nerves directly coordinate the rapid escape response bypassing the central integrative struct

247 of sst1.1 did not impact acousto-vestibular escape responses but led to abnormal exploration.

248 These inputs, which mediate escape responses to sudden stimuli, may be modulated by

249 edation risk and information about efficient escape routes affect an individual's ability to avoid or

250 ng opportunistic pathogens methanogens which escape routine detection remains to be described.

251 e pressure on the clonal dynamics and immune escape signature by comparing glioma growth in immunocom

252 The identified murine immune escape signature was reflected in human patients and cor

253 In this review, we briefly discuss endosomal escape strategies and review the strategy of cell membra

254 ndings 1) demonstrate that EBV dovetails its escape strategy to a key cellular danger-sensing mechani

255 Nts) neurons are selectively tuned to active escape stress and can reduce food consumption via effect

256 Our model accurately predicted the relative escape success for impala escaping from cheetah in open

257 avanna versus acacia thicket habitat, though escape success was consistently underestimated.

258 ell repeatedly failed to eliminate all rapid escapes, suggesting that escapes can equally well be dri

259 ther D614G might also mediate neutralization escape that could compromise vaccine efficacy, sera from

260 ts an alternative method whereby tumor cells escape the critical shortening of telomeres.

261 Orai1-SNPs escape the degradation pathway and instead enter Rab 11-

262 the host antiviral protein as it evolves to escape the effects of viral antagonists.

263 While individuals seem to be unable to escape the fitness effects of their morphology, they may

264 r cure, in part due to the ability of HSV to escape the host immune response by various mechanisms.

265 mRNA methyltransferases that have evolved to escape the host's cell immunity response following virus

266 riability of HCV and its ability to actively escape the immune response, a goal of HCV vaccine design

267 In conclusion, S. aureus organisms that escape the infected bone may recover the expression of k

268 growth in juvenile and adult zebrafish that escape the larval lethality.

269 Cancers often escape the polyamine biosynthesis inhibitors by increase

270 These models escape the preantral follicle block and in response to s

271 ease is important for Pol II to successfully escape the promoter as initiating complexes transition i

272 suggest that mRNA stem-loops can transiently escape the ribosome helicase by binding to the A site.

273 delay period allows the majority of cells to escape the small vessels of the tissues before fibers fo

274 It is known for its ability to escape the therapeutic options available to date thanks

275 the yeast is able to adapt dramatically and escape the vigilance of the host's immune cells to survi

276 ced higher yields from the panicles that had escaped the heat, compared with the control.

277 of high-affinity self-reactive T cells also escaped the thymus following HSCT during chronic infecti

278 s ( ), the amount of concentrated CO(2) that escapes the bundle-sheath cells, for the chilling-tolera

279 ere, where it is dissociated to hydrogen and escapes the planet.

280 les, and real-time measurement of gas fluxes escaping the surface of the sand.

281 However, viral escape through mutation of the HIV-1 envelope glycoprote

282 educed absolute lateralization and increased escape time at the lowest DO levels, whereas behavioral

283 The increase in escape time occurs only when the threshold density-the a

284 To do so, we measured the "escape time" required for drug-resistant Escherichia col

285 -particle tracking experiments have measured escape times of DNA-binding species diffusing in living

286 bacter pylori and Campylobacter jejuni, have escaped TLR5 activation by mutations in this epitope.

287 to avoid the NOX2 activity in phagosomes and escape to the cytosol.

288 The model predicts that, without immune escape, tumor neoantigens are either clonal or at low fr

289 ts may explain the ongoing problems of viral escapes, unpredictable autoimmunity, and heterogeneous r

290 r function, driving the selection of a viral escape variant.

291 tecting antibiotic resistance and diagnostic escape variants in Neisseria gonorrhoeae, a pathogen ass

292 Escape variants with such extended CP fail to be transmi

293 ight retain protective activity even against escape variants.

294 hanisms that can favour migration: moving to escape versus recover from infection.

295 mologous ferret antiserum resulted in immune escape viruses containing amino acid substitutions alani

296 e critical for survival, immune evasion, and escape, while the importance of catabolism of host-deriv

297 rnal X chromosome but linger in regions that escape X chromosome inactivation.

298 c dosage of Kdm5c, an X chromosome gene that escapes X chromosome inactivation, as a determinant of t

299 USP9X escapes X inactivation, and in female subjects de novo h

300 antly decreases the expression of genes that escape XCI.