ライフサイエンスコーパス: estrogen receptor beta

1 nantiomer has a relatively high affinity for estrogen receptor beta.

2 xes containing retinoic X receptor alpha and estrogen receptor beta.

3 he TSU-PR1 cell line contains high levels of estrogen receptor beta.

4 mice deficient in estrogen receptor alpha or estrogen receptor beta.

5 Estrogen receptor beta 2 (ERbeta2), an ERbeta1 splice va

6 Estrogen receptor beta, a homologue to estrogen receptor

7 activity, prolactin effects, and aspects of estrogen receptor beta activity.

8 Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows potent,

9 Estradiol, and the specific estrogen receptor-beta agonist DPN, decreased current am

10 The estrogen receptor-beta agonist provided a comparable lev

11 WAY-202196, a nonsteroidal selective estrogen receptor-beta agonist, was tested in the murine

12 17-beta-Estradiol or estrogen receptor beta agonists dipropylnitrile and beta

13 New diphenolic azoles as highly selective estrogen receptor-beta agonists are reported.

14 (betaERKO(-/-)), estrogen receptor-alpha and estrogen receptor-beta (alphabetaERKO(-/-)), and GPER (G

15 e, estrogen receptor alpha (XbaI and PvuII), estrogen receptor beta (AluI), and estrogen receptor bet

16 ly through L- and R-type VGCCs by activating estrogen receptor beta and GPR30, respectively.

17 5 were transcriptionally induced by liganded estrogen receptor beta and inhibited by androgen recepto

18 In situ hybridization for mRNA encoding estrogen receptor beta and progesterone receptor was car

19 leaflet were also found to express mRNA for estrogen receptor beta and progesterone receptor.

20 d fatty acid oxidation, are regulated by the estrogen receptor-beta and consequently contribute to ca

21 common variants in estrogen receptor-alpha, estrogen receptor-beta and the progesterone receptor pro

22 ii) 3beta-Diol is a pro-apoptotic ligand for estrogen receptor beta, and (iii) 3beta-tetrahydrosteroi

23 tifs have diverse affinities for the VDR and estrogen receptor beta, and mutation of specific motifs

24 androgen receptor, estrogen receptor alpha, estrogen receptor beta, and progesterone receptor mRNA a

25 hat are potent and selective agonists of the estrogen receptor beta, and that are selectively cytotox

26 in estrogen receptor-alpha (alphaERKO(-/-)), estrogen receptor-beta (betaERKO(-/-)), estrogen recepto

27 Expression of the estrogen receptor beta by CD4(+) T cells was necessary f

28 r cells to be transcriptionally regulated by estrogen receptor-beta coupled to Ago2, whereas male Ago

29 d PvuII), estrogen receptor beta (AluI), and estrogen receptor beta(cx) (Tsp509I), endothelial nitric

30 to isoflavones and to placebo was found with estrogen receptor beta(cx) Tsp509I genotype AA, but not

31 ), estrogen receptor-alpha (EC50 17 nM), and estrogen receptor-beta (EC50 27.5 nM), while the corresp

32 estrogen receptor-alpha (EC50 58.7 nM), and estrogen receptor-beta (EC50 78.5 nM).

33 The discovery of estrogen receptor beta (ER beta) and subsequent localiza

34 n in CNP we used a combination therapy of an estrogen receptor beta (ER beta) inhibitor with a sTNF/T

35 n of the estrogen receptor alpha (ER alpha), estrogen receptor beta (ER beta), progesterone receptor

36 and in vitro models to determine the role of estrogen receptor beta (ER-beta) and its ligands on adip

37 Estrogen receptor beta (ER-beta) and its selective ligan

38 Estrogen receptor beta (ER-beta) regulates diverse physi

39 nd to estrogen receptor alpha (ER-alpha) and estrogen receptor beta (ER-beta), and antagonize the act

40 black cohosh to the ligand binding domain of estrogen receptor beta (ER-beta).

41 that express the more recently characterized estrogen receptor-beta (ER-beta) has not been examined i

42 It has been shown that the activation of estrogen receptor-beta (ER-beta) plays an important card

43 oughly characterized for its specificity for estrogen receptor-beta (ER-beta), was used to immunoloca

44 DNF, estrogen receptor-alpha (ER-alpha), and estrogen receptor-beta (ER-beta), we found only sparse c

45 e we describe the generation of mice lacking estrogen receptor beta (ERbeta -/-) by insertion of a ne

46 This effect is mediated by estrogen receptor beta (ERbeta) acting as a monomer, whe

47 Estrogen receptor beta (ERbeta) activates transcription

48 In particular, estrogen receptor beta (ERbeta) agonists have been shown

49 ncurrently to a data set of highly selective estrogen receptor beta (ERbeta) agonists.

50 Estrogen receptor beta (ERbeta) and androgen receptor (A

51 IMP3 expression is repressed specifically by estrogen receptor beta (ERbeta) and its ligand 3betaA-di

52 The two receptors are estrogen receptor beta (ERbeta) and liver X receptor bet

53 TAM engaged mitochondrial estrogen receptor beta (ERbeta) as an antagonist in MCF7

54 -length estrogen receptor alpha (ERalpha) or estrogen receptor beta (ERbeta) bound to a fluorescein-l

55 Activation of estrogen receptor beta (ERbeta) but not ERalpha rescued

56 the transcription factors DLX5 and EGR3 and estrogen receptor beta (ERbeta) directly controlling its

57 The current study examined whether estrogen receptor beta (ERbeta) expression in spine syna

58 Loss of estrogen receptor beta (ERbeta) expression in the gut is

59 Little is known about endogenous estrogen receptor beta (ERbeta) gene targets in human br

60 in vivo from the hearts of wild-type but not estrogen receptor beta (ERbeta) gene-deleted mice admini

61 Estrogen receptor beta (ERbeta) has emerged as a promisi

62 Estrogen receptor beta (ERbeta) has potent antiprolifera

63 Although the distribution of estrogen receptor beta (ERbeta) immunoreactivity in the

64 Selective deletion of estrogen receptor beta (ERbeta) in astrocytes, but not n

65 sion of estrogen receptor alpha (ERalpha) or estrogen receptor beta (ERbeta) in the hippocampus of ag

66 ion of estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) in the mouse cortex duri

67 t, selective binding and agonist function in estrogen receptor beta (ERbeta) in vitro assays.

68 Estrogen receptor beta (ERbeta) is a favorable therapeut

69 Estrogen receptor beta (ERbeta) is activated in the pros

70 Estrogen receptor beta (ERbeta) is emerging as a critica

71 The estrogen receptor beta (ERbeta) is emerging as an import

72 Estrogen receptor beta (ERbeta) is essential for migrati

73 Estrogen receptor beta (ERbeta) is expressed in cortical

74 By contrast, estrogen receptor beta (ERbeta) is expressed in many bra

75 Estrogen receptor beta (ERbeta) is expressed in microgli

76 rian granulosa cells, we discovered that the estrogen receptor beta (ERbeta) is inducible by activin.

77 In lung adenocarcinoma cells, the estrogen receptor beta (ERbeta) is the predominating for

78 In 1998, an estrogen receptor beta (ERbeta) knockout (KO) mouse was

79 Disagreements about the phenotype of estrogen receptor beta (ERbeta) knockout mouse, created

80 use dihydrotestosterone is the precursor for estrogen receptor beta (ERbeta) ligands, 5AR inhibitors

81 While estrogen receptor beta (ERbeta) may impact the progressi

82 Early clinical studies indicated that estrogen receptor beta (ERbeta) might play key roles to

83 f midbrain DA neurons are immunopositive for estrogen receptor beta (ERbeta) or androgen receptors (A

84 Estrogen receptor beta (ERbeta) plays an important role

85 In the brain, estrogen receptor beta (ERbeta) plays important roles in

86 Estrogen receptor beta (ERbeta) promotes the degradation

87 eloped that selectively bind to and activate estrogen receptor beta (ERbeta) rather than estrogen rec

88 This regulation involves Estrogen Receptor beta (ERbeta) recruitment to the Elect

89 Estrogen receptor beta (ERbeta) selective agonists are c

90 of Blood, Yakimchuk and colleagues show that estrogen receptor beta (ERbeta) signaling can act tumor-

91 eviously reported that antiestrogen-liganded estrogen receptor beta (ERbeta) transcriptionally activa

92 for the localization of the newly identified estrogen receptor beta (ERbeta) within the rat paraventr

93 ptors (estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta)) that bind 17beta-estrad

94 Estrogen receptor beta (ERbeta), a less active ER subtyp

95 Moreover, siRNA-mediated knockdown of estrogen receptor beta (ERbeta), but not ERalpha, abolis

96 Recent studies suggest that estrogen receptor beta (ERbeta), may function as a tumor

97 eceptors, estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), or the G protein-couple

98 This effect is mediated by estrogen receptor beta (ERbeta), which directly associat

99 Estrogen effects are mediated by estrogen receptor beta (ERbeta), which reduces chromatin

100 r smooth muscle cells and blood vessels from estrogen receptor beta (ERbeta)-deficient mice exhibit m

101 Activation of estrogen receptor beta (ERbeta)-expressing neurons regul

102 We have previously shown that estrogen receptor beta (ERbeta)-mediated up-regulation o

103 Diarylpropionitrile (DPN), an estrogen receptor beta (ERbeta)-specific agonist, and to

104 pothesis that defeminization is regulated by estrogen receptor beta (ERbeta).

105 ish estrogen receptor with homology to human estrogen receptor beta (ERbeta).

106 learning and memory via the newly discovered estrogen receptor beta (ERbeta).

107 interacted with the ligand-binding domain of estrogen receptor beta (ERbeta).

108 ha (ERalpha) and as a complete antagonist on estrogen receptor beta (ERbeta).

109 ene expression through an effect mediated by estrogen receptor beta (ERbeta).

110 blocks estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta).

111 ptors, estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta).

112 nd for estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta).

113 y demonstrated mitochondrial localization of estrogen receptor beta (ERbeta).

114 ymphoma is repressed following activation of estrogen receptor beta (ERbeta, ESR2).

115 over, pharmacologic inhibition of microglial estrogen receptor-beta (ERbeta) function corrects the re

116 These mice express the newly described estrogen receptor-beta (ERbeta) in their aortas, suggest

117 In EAE, remyelination was induced with estrogen receptor-beta (ERbeta) ligand treatment, and up

118 structure-based optimization of a series of estrogen receptor-beta (ERbeta) selective ligands.

119 Estrogen receptor-alpha (ERalpha), estrogen receptor-beta (ERbeta), and progestin receptor

120 al of this study was to determine whether an estrogen receptor-beta (ERbeta)-selective agonist (GTx-8

121 ptors, estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta).

122 cta (SNpc) DA neurons are immunoreactive for estrogen receptor-beta (ERbeta).

123 ptors [estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta)] to promote changes in p

124 s [estrogen receptor alpha (XbaI and PvuII), estrogen receptor beta [ERbeta (AluI) and ERbeta[cx] (Ts

125 Estrogen receptors beta (ERbetas) are present in PVN neu

126 ation by steroid receptors, and we show that estrogen receptor beta (ESR2) is the main vector of estr

127 Fluoxetine and EE2 alone did not affect estrogen receptor beta (esr2), but the co-exposure down

128 ceptor (Ar), estrogen receptor alpha (Esr1), estrogen receptor beta (Esr2), glucocorticoid receptor (

129 rough estrogen receptor alpha (ESR1) but not estrogen receptor beta (ESR2).

130 alignancies according to tumor expression of estrogen receptor-beta (ESR2).

131 n-related receptor, estrogen receptor-alpha, estrogen receptor-beta, farnesoid X receptor, and mast c

132 the hypothesis that sequence variants of the estrogen receptor beta gene (ESR2) may be associated wit

133 gnition and psychological resources, and the estrogen receptor beta gene (ESR2) polymorphism rs297838

134 women but may increase HDL cholesterol in an estrogen receptor beta gene-polymorphic subgroup.

135 The novel estrogen receptor beta has also been detected in lung tu

136 ar interactions between these components and Estrogen Receptor Beta, identified as a potential target

137 Although specific effects mediated by estrogen receptor beta in vivo remain to be elucidated,

138 ch interact with estrogen receptor-alpha and estrogen receptor-beta in multiple tissues, continue to

139 ound that GnRH neurons exclusively expressed estrogen receptor-beta in rats and against the current c

140 Pharmacologic activation of estrogen receptor beta increases mitochondrial function,

141 found that the vitamin D receptor (VDR) and estrogen receptor beta interact with different alpha-hel

142 sexual motivation through the activation of estrogen receptor beta interacting with the metabotropic

143 Here, we report that estrogen receptor beta is alternatively modified by eith

144 S-equol has a high affinity for estrogen receptor beta (K(i) = 0.73 nmol/L), whereas R-e

145 ast to ERalphaKO mice, IA performance by OVX estrogen receptor-beta-knockout (ERbetaKO) mice was not

146 nge (HDX) mass spectrometry in analyzing the estrogen receptor beta ligand binding domain (ERbeta LBD

147 taining revealed estrogen receptor-alpha and estrogen receptor-beta localized in the nucleus and cyto

148 overy of a second estrogen receptor subtype, estrogen receptor-beta, may significantly advance our un

149 anslated protein first suggested that murine estrogen receptor beta (mER-beta) is O-GlcNAcylated.

150 Recently, we demonstrated that the murine estrogen receptor-beta (mER-beta) is alternatively O-Glc

151 Expression of estrogen receptor-alpha and estrogen receptor-beta mRNA in lumbar spinal cord was sh

152 ith sulforaphane and diarylpropionitrile, an estrogen receptor beta selective agonist, results in NRF

153 ent with the hypothesis of a joint effect of estrogen receptor beta sequence variants and endogenous

154 and its receptor, oxytocin and its receptor, estrogen receptor beta, serotonin receptors (Htr1a, Htr2

155 BPS on myocyte Ca2+ handling was mediated by estrogen receptor beta signaling and by rapid increases

156 and associated VTA(DA) activity through VTA estrogen receptor beta signaling.

157 Treatment with an estrogen receptor beta-specific agonist and androgen dep

158 We propose that E2, acting through estrogen receptor-beta, transactivates synaptic TrkB and

159 modifications may play a role in regulating estrogen receptor beta transactivation and turnover.

160 Expression of estrogen receptor beta was increased in lesions compared

161 suming soy foods, has selective affinity for estrogen receptor-beta, whereas both enantiomers modulat

162 rogen receptors (estrogen receptor-alpha and estrogen receptor-beta), which bind to DNA and function

163 d from women and mice are immunopositive for estrogen receptor beta, with up to 20% being estrogen re