ライフサイエンスコーパス: estrogenic

1 lic precursor of 8-prenylnaringenin, was not estrogenic.

2 rogenic (5alpha-dihydrotestosterone; DHT) or estrogenic (17beta-estradiol; E(2)) metabolites.

3 androgens) and the prodrug tibolone (Tib) to estrogenic 3alpha/beta-hydroxytibolones.

4 an uterine (Ishikawa) cells to determine the estrogenic action of D3 on the activation and nuclear tr

5 was found to maintain bone density of rats (estrogenic action) while simultaneously preventing mamma

6 brain testosterone plays both androgenic and estrogenic actions due to its conversion into estrogen v

7 elated differences in estrogen receptors and estrogenic actions in the brain are discussed, with the

8 a physiologically relevant role in mediating estrogenic actions on energy expenditure in females.

9 Following estrogenic activation, the estrogen receptor-alpha (ERal

10 s via ERalpha, licorice might have different estrogenic activities due to its ERbeta selectivity, par

11 We therefore examined GPR30 in estrogenic activities in ER-positive MCF-7 breast cancer

12 key and novel mechanistic differences in the estrogenic activities of BEs vs. E2, with BEs displaying

13 To evaluate the AF-1 involvement in the estrogenic activities of various compounds, we analyzed

14 of liquiritigenin, demonstrated significant estrogenic activities while xanthohumol, a metabolic pre

15 nts of liquiritigenin have various levels of estrogenic activities, suggesting the importance of prec

16 crobial, acetylcholinesterase inhibitory and estrogenic activities.

17 m is a toxic and persistent heavy metal with estrogenic activities.

18 proton only led to moderate reduction of the estrogenic activities.

19 stances found in food contact materials with estrogenic activity (EA) have created substantial demand

20 limited bioassay data are available on their estrogenic activity (EA).

21 ns observed in surface waters failed to show estrogenic activity (induction of vitelloginin mRNA).

22 ug standard-EQ/g of sorbent range), and weak estrogenic activity (ng E2-EQ/g of sorbent range).

23 ding to goldfish testis androgen receptors), estrogenic activity (yeast estrogen screen), and neurotr

24 was found to be the greatest contributor to estrogenic activity across all sample types.

25 Zea had strong estrogenic activity and activated both the AF-1 and AF-2

26 l incorporated into plastics and resins, has estrogenic activity and is associated with adverse healt

27 t in vitro STS inhibitor without undesirable estrogenic activity and with osteogenic properties, we a

28 Although heightened estrogenic activity and/or reduced progesterone responsi

29 The three EDCs showed strong estrogenic activity as agonists for ERalpha in a dose-de

30 he E-isomers of FR 4OHT and endoxifen had no estrogenic activity at therapeutic serum concentrations.

31 n of parent compounds into degradates having estrogenic activity can explain their environmental pers

32 studies, fractions of groundwater with high estrogenic activity contained hetero-PAHs and their hydr

33 The estrogenic activity decreased in the order H. lupulus >

34 as also paid to monitoring of changes in the estrogenic activity during these particular in vitro exp

35 Given that 2,4OH-BP possesses an estrogenic activity higher than that of 2OH-4MeO-BP, our

36 re collected, extracted, and found to elicit estrogenic activity in laboratory fish.

37 selected hetero-PAHs were screened for their estrogenic activity in lyticase yeast estrogen screen (L

38 ated against 17beta-estradiol (E2) for their estrogenic activity in MCF-7 human breast cancer cells.

39 BPA carries an anti-estrogenic activity in the germline and results in germl

40 decreased estrogen deprivation and increased estrogenic activity in the liver, whereas such benefit w

41 TMBPF did not show estrogenic activity in the uterotrophic assay and did no

42 Estrogenic activity in the yeast estrogen screen and T47

43 s is known about their potential toxicity or estrogenic activity in vivo.

44 e mechanism by which glucocorticoids inhibit estrogenic activity is unknown.

45 levant concentrations may be associated with estrogenic activity measured in water extracts and feral

46 tinel Potamopyrgus antipodarum confirmed the estrogenic activity of BPA in vivo at 30 mug/L.

47 esigned to characterize the toxicity and the estrogenic activity of chemicals.

48 In this study, we investigate the estrogenic activity of components of plastics coming fro

49 Estrogenic activity of compounds can be measured by many

50 f mERbeta2 in mouse tissues and assessed the estrogenic activity of EDCs through mERbeta2.

51 The estrogenic activity of isoliquiritigenin could be the re

52 The estrogenic activity of parabens was considerably reduced

53 bioassay using T47D-KBluc cells showed that estrogenic activity of receiving water near the outflow

54 lvement of Wnt/beta-catenin signaling in the estrogenic activity of this diarylheptanoid in transfect

55 benchmarked and evaluated for predicting the estrogenic activity of unknown compounds.

56 es of Bisphenol A (ClxBPA), that have higher estrogenic activity than BPA.

57 mERbeta2 showed weaker estrogenic activity than mERbeta1 in our in vitro system

58 y has also been documented in the removal of estrogenic activity that correlated with the EE2 degrada

59 of 16 compounds tested by reporter assay had estrogenic activity through mERbeta2.

60 ions, had no hormone-like activities whereas estrogenic activity was found in the filtered tap water.

61 Evaluation of estrogenic activity was further characterized by in vitr

62 Estrogenic activity was only associated with Brazilian e

63 ion of steroid hormones, phytoestrogens, and estrogenic activity was thoroughly characterized within

64 To verify this effect was caused by reduced estrogenic activity we confirmed that in hypoxic mice in

65 ural steroid hormones and phytoestrogens and estrogenic activity were assessed across the lagoon/spra

66 ninolytic enzymes were found to decrease the estrogenic activity with EE2 removal proportionally.

67 in a markedly elevated load of analytes and estrogenic activity within lagoon sludge.

68 In females, uterine mass (an indicator of estrogenic activity) was also greatest on high P:C diets

69 PAH exposure, general and oxidative stress, estrogenic activity, and defense against metals.

70 ls in the environment, especially those with estrogenic activity, are able to disrupt the programming

71 al disrupting chemical bisphenol A (BPA) has estrogenic activity, but its implications in pain are mo

72 ls require in vitro data prior to predicting estrogenic activity, but machine learning methods are ca

73 xyestrone, an estrone metabolite with little estrogenic activity, is found to have the strongest neur

74 BPA), an environmental contaminant with weak estrogenic activity, resists microbial degradation under

75 Experiments confirmed a weak estrogenic activity, supporting the reliability of the p

76 Other test compounds used possessed partial estrogenic activity.

77 m-carbamoylbenzyl)-E2 to remove its unwanted estrogenic activity.

78 yeast estrogen screen was used to determine estrogenic activity.

79 rom the medicinal plant, Curcuma comosa, has estrogenic activity.

80 gens, but contributed minimally toward total estrogenic activity.

81 eed been shown to have a heightened level of estrogenic activity.

82 samples by the p-YES results in profiles of estrogenic activity.

83 tudies have shown that parabens possess weak estrogenic activity.

84 ell known endocrine-disrupting chemical with estrogenic activity.

85 performance of in vitro assays that measure estrogenic activity.

86 ta-HSD1 inhibitors, and their proliferative (estrogenic) activity on estrogen-sensitive cells.

87 potential psychoprotective effects and fewer estrogenic adverse effects.

88 Our findings suggest that D3 is a weak estrogenic agonist compound.

89 k which has spurred research into developing estrogenic alternatives that have the beneficial effects

90 isoflavones, which are a class of potential estrogenic alternatives.

91 rtually screen chemicals for their potential estrogenic and androgenic activities.

92 hemicals with potential to interact with the estrogenic and androgenic pathways, and could help prior

93 and transcriptional-reporter gene assays for estrogenic and anti-androgenic activity were performed o

94 nd personal-care products and their reported estrogenic and antiandrogenic activity.

95 Similarly, a combination of estrogenic and chemopreventive properties has been repor

96 mass spectrometry (negative ion) of selected estrogenic and nonestrogenic fractions identified compou

97 rous adverse health outcomes relating to its estrogenic and other hormonal properties, but direct cau

98 arbonate plastic and epoxy resins, is weakly estrogenic and therefore of environmental and human heal

99 and non-o-PCBs as well as for nondioxin-like estrogenic and thyroid-like congeners with prevalent and

100 All TPEs were estrogenic and, unlike 4-hydroxytamoxifen (4OHTAM) and E

101 Bisphenol-A (BPA) has been shown to modulate estrogenic, androgenic, and anti-androgenic effects.

102 ing cell-based reporter gene assays revealed estrogenic, androgenic, and dioxin-like activity in AF e

103 Direct estrogenic, androgenic, or steroidogenic mechanisms are

104 In vitro bioassays for (anti)estrogenic, (anti)androgenic as well as retinoic acid- a

105 Untreated wastewater induced antiandrogenic, estrogenic, antiestrogenic, and retinoid-like activity.

106 r of magnitude and of similar action as BPA (estrogenic, antiestrogenic, androgenic, and antiandrogen

107 ted biphenyls (PCBs) have been shown to have estrogenic, antiestrogenic, or antiandrogenic properties

108 d (Z-BDDA) is a seco-steroid that has potent estrogenic as well as antioxidant activities in vitro an

109 they highlight the need for estimating total estrogenic burden rather than single analyte or chemical

110 These agents are proposed as safer estrogenic candidates compared with 17beta-estradiol (E(

111 naturally occurring phytochemicals with weak estrogenic cellular effects.

112 mical:gene covariation as the most impactful estrogenic chemical across all exposure sites.

113 gest new targets for abnormal programming by estrogenic chemicals and provide evidence supporting the

114 oreporter was characterized with mixtures of estrogenic chemicals and tested with spiked influent was

115 Estrogenic chemicals are widespread environmental contam

116 tes that the in vitro effects of mixtures of estrogenic chemicals can be well predicted from the estr

117 orescence responses for a range of different estrogenic chemicals in the new transgenic zebrafish mod

118 y outcome produced by a reference mixture of estrogenic chemicals was examined.

119 the effects of mixtures composed of up to 17 estrogenic chemicals were examined using estrogenicity a

120 The fate of two estrogenic chemicals, the UV filter benzophenone-2 (BP2)

121 nd highly integrative system for identifying estrogenic chemicals, their target tissues and effect co

122 east progenitor cells chronically exposed to estrogenic chemicals.

123 er samples with high concentrations of other estrogenic chemicals.

124 t risk of the mixture effect caused by other estrogenic chemicals.

125 atively modulate) the effect of a mixture of estrogenic chemicals.

126 estrogen receptor by reducing levels of the estrogenic cholesterol metabolite 27-hydroxycholesterol.

127 ng effect directed analysis, the presence of estrogenic components in untreated and biologically trea

128 Ps and sources of exposure of humans to this estrogenic compound are not well-known.

129 er electronics likely constitute a source of estrogenic compound contamination in the indoor environm

130 erve as both a sink and a source of the more estrogenic compound E2.

131 Early-life exposure to estrogenic compounds affects the development of the repr

132 aordinary reliability in identifying diverse estrogenic compounds and in differentiating between thei

133 These results identify estrogenic compounds as phenotypic suppressors and illum

134 of Opportunity" theory, which suggests that estrogenic compounds can exert positive effects on verba

135 However, different estrogenic compounds can modify the Tip60 action.

136 In contrast, estrogenic compounds derepressed the opposite effects of

137 Genistein and daidzein are two estrogenic compounds derived from plants, especially leg

138 fants exposed to abnormal estrogen levels or estrogenic compounds during pregnancy.

139 veloped to perform the continuous removal of estrogenic compounds from polluted wastewaters.

140 data indicate that gestational exposures to estrogenic compounds impact risk of hypospadias.

141 rs that can distinguish structurally similar estrogenic compounds in natural waters.

142 shows exact formulas and masses of possible estrogenic compounds in OSPW.

143 The presence of estrogenic compounds in water and their deleterious effe

144 ines of research suggest that estrogens (and estrogenic compounds) are neuroprotective following expe

145 effects and at cytotoxic levels of analyzed estrogenic compounds, which is not possible with the cla

146 in the response to environmentally relevant estrogenic compounds.

147 deleted mice administered angiotensin II and estrogenic compounds.

148 adrenal androgen production inhibitors, and estrogenic compounds.

149 r leading to weakened vasodilatory action of estrogenic compounds.

150 yzed plastics samples showed the presence of estrogenic compounds.

151 that are relevant to the risk assessment of estrogenic compounds.

152 K(+) current reduction in high estrogenic conditions were associated with prolongation

153 Whereas most attention has been focused on estrogenic congeners, we tested the cancer-inducing pote

154 en is on par with that of the better-studied estrogenic contaminant 17alpha-ethinylestradiol.

155 Furthermore, by 2050 a moderate increase in estrogenic contamination and the potential risk to wildl

156 eatic responses to MI-TP, and androgenic and estrogenic contributions to such responses (direct fetal

157 osynthesis of choline and this gene is under estrogenic control, we hypothesized that there are SNPs

158 tant increase in temperature and exposure to estrogenic EDCs on reproduction and development in an es

159 is potentially dysregulated upon exposure to estrogenic EDCs.

160 supplements may be exposed to high levels of estrogenic EDs.

161 Exposure to estrogenic EEDs in utero was associated with adverse hea

162 d with Irganox 1076 induced a dose-dependant estrogenic effect in vitro.

163 ld be performed to evaluate the toxicity and estrogenic effect of alpha-ZOL/ZEA-AITC.

164 5), consistent with in vitro evidence for an estrogenic effect of this compound.

165 -estradiol, the most powerful substance with estrogenic effect.

166 tion has important implications on long term estrogenic effects affecting smooth muscle and neural fu

167 Estrogenic effects are mediated through two estrogen rec

168 r, the molecular mechanisms underlying these estrogenic effects are unknown.

169 corice extracts; however, it exhibited lower estrogenic effects compared to 8-prenylnaringenin in fun

170 It was possible to detect and quantify estrogenic effects in all investigated sample types, eve

171 )-based in vitro screening assays to predict estrogenic effects in aquatic species.

172 /L estimated effects-based trigger value for estrogenic effects in male fish.

173 The unexpectedly high estrogenic effects in many samples indicated the impact

174 of E2 in breast cancer therapy but minimizes estrogenic effects in other tissues is a novel, therapeu

175 ng chemical bisphenol A (BPA) while exerting estrogenic effects of comparable potency.

176 in vitro data that raise the possibility of estrogenic effects of isoflavones contained in SF.

177 in vitro, raloxifene does not share the pro-estrogenic effects of tamoxifen on the endometrium.

178 current study was to evaluate the potential estrogenic effects of three licorice species (Glycyrrhiz

179 level is significantly reduced and that the estrogenic effects on apoA-IV gene expression and food i

180 This was consistent with identification of estrogenic effects on gene expression, high BPA exposure

181 nd neuroanatomical studies that suggest that estrogenic effects on song processing might be mediated

182 eated female zebra finches to investigate if estrogenic effects on song responsiveness are mediated v

183 igh antiandrogenic and minor dioxin-like and estrogenic effects persisted in the treated effluent tha

184 se BPA alternatives induce similar toxic and estrogenic effects to BPA and that BPAF is more potent t

185 ollutants and pathogens and the reduction of estrogenic effects, whereas the in vitro mutagenicity in

186 ustries (OSPW) have been reported to exhibit estrogenic effects.

187 corticoids yet transduces their actions into estrogenic effects.

188 contraceptive adjuvant, the impact of these estrogenic endocrine disrupting chemicals (EDCs) on the

189 xpression is also increased upon exposure to estrogenic endocrine disrupting chemicals (EDCs) such as

190 onmental factors, such as antiandrogenic and estrogenic endocrine disrupting chemicals (EDCs), are su

191 Bisphenol A (BPA) is an estrogenic endocrine disruptor widely used in the produc

192 Diethylstilbestrol (DES) is an estrogenic endocrine disruptor with long-term health eff

193 minates some foods and tobacco plants, is an estrogenic endocrine disruptor.

194 Previously estrogenic endocrine disruptors (EDs) were detected in 8

195 e experimental data suggest that they act as estrogenic endocrine disruptors.

196 Exposure of the TG fish to estrogenic endocrine-disrupting chemicals (EDCs) induced

197 reduced by APV and Rp-cAMPS, suggesting that estrogenic enhancement of object memory involves NMDA re

198 reshwaters and constitutes another source of estrogenic exposure for wildlife.

199 ns of singular steroidal estrogens or to the estrogenic extract of an anaerobic swine waste lagoon.

200 idence that endogenous ERalpha AF-1 dominant estrogenic-genes exist in estrogen-responsive organs.

201 is no information determining AF-1-dependent estrogenic-genes existing in tissues.

202 We sought to identify AF-1-dependent estrogenic-genes using the AF-2 mutated knock-in (KI) mo

203 r important new insights into the ability of estrogenic GPER signaling to trigger HIF1alpha-dependent

204 ility of experiments as shown by morphology, estrogenic growth dose-response, whole genome gene expre

205 metal pollutant that may act as an exogenous estrogenic hormone.

206 ion kinetics and mechanisms of three natural estrogenic hormones (17alpha-estradiol, 17beta-estradiol

207 k of literature concerning androgenic versus estrogenic hormones in environmental matrices.

208 ntly contains high concentrations of steroid estrogenic hormones.

209 Assessment of the estrogenic hypothalamic-pituitary-gonadal axis regulatio

210 ratio (HR) = 1.93 (95% CI: 0.93, 4.00)] and estrogenic II PCB group [HR = 1.90 (95% CI: 0.96, 3.78)]

211 No estrogenic impact on biochemical endpoints was observed

212 BPA and DMIP were estrogenic in high concentrations.

213 Together, these results support an estrogenic influence of HDAC4 regulation and expression

214 were exposed to environmental levels of the estrogenic insecticide bifenthrin or ethinylestradiol (E

215 Daidzein (1) is a natural estrogenic isoflavone.

216 Estrogenic isoflavones were found, in the 1940s, to disr

217 p,p -DDE with development in response to its estrogenic isomer, o,p -DDE [1,1-dichloro-2-(o-chlorophe

218 folding-biosensor is useful in evaluation of estrogenic ligands and their downstream effects, and in

219 ort here that 1 can be transformed into anti-estrogenic ligands by simple alkyl substitutions of the

220 ellogenin/choriogenin induction by different estrogenic ligands correlated positively with preferenti

221 rs in vivo and to distinguish the ability of estrogenic ligands to promote ER homo- vs. heterodimeriz

222 binding pocket and compete for binding with estrogenic ligands.

223 .76 (95% CI: 1.14, 6.73), as well as for two estrogenic-like PCB groups, and the thyroid-like group [

224 nd suburban ponds may be contributing to the estrogenic load within suburban freshwaters and constitu

225 ish embryo-larvae and an assessment on their estrogenic mechanisms in an estrogen-responsive transgen

226 erentiated endpoints studied to date rely on estrogenic mechanisms in other mammals.

227 though multiple studies have concentrated on estrogenic mechanisms of disease modulation, fairly litt

228 , as developmental stage influences cellular estrogenic mechanisms.

229 sex-specific influences on striatal cellular estrogenic mechanisms.

230 unction, the molecular mechanisms underlying estrogenic memory modulation remain largely unknown.

231 potently stimulated by estradiol as well as estrogenic metabolites of 5alpha-dihydrotestosterone.

232 e of male sexual motivation are activated by estrogenic metabolites of testosterone (T) in a fast man

233 rmethrin, biotransformation of bifenthrin to estrogenic metabolites was not observed in medaka liver

234 ssment of aquatic systems, including complex estrogenic mixtures.

235 Estrogenic modulation of perception in songbirds and per

236 induce any toxic effects (cyto-genotoxicity, estrogenic or anti-androgenic activity) in vitro at rele

237 any EDCs studied thus far in fish have known estrogenic or antiestrogenic effects, and as such cause

238 iphenyltrichloroethane (DDT) is a persistent estrogenic organochlorine pesticide that is a rodent hep

239 drive biomarker induction in fish exposed to estrogenic pollutants and provide a case study on the ca

240 lations have evolved adaptations to tolerate estrogenic pollution by comparing frequency differences

241 Despite the estrogenic potencies of BP derivatives, few studies have

242 as these products were shown to have a lower estrogenic potency but are expected to have a higher bio

243 The highest estrogenic potency in ERalpha-positive MCF-7/2a cells wa

244 ly reported, although this can influence the estrogenic potency of test compounds.

245 revealed augmented SSFs reduced the overall estrogenic potency of the supplied water by 25% on avera

246 8-Prenylnaringenin had nanomolar estrogenic potency without ER selectivity while xanthohu

247 cumulated these concentrations normalized by estrogenic potency.

248 eir prevalence in the environment and strong estrogenic potency.

249 pid mechanistic/phenotypic evaluation of the estrogenic potential of many chemicals.

250 ver exposure of humans to BP-3, owing to the estrogenic potential of this compound.

251 es involved in these pathways have different estrogenic potentials, as implied by our analysis of the

252 Tibolone has estrogenic, progestogenic, and androgenic effects.

253 ved compounds found mainly in soy with known estrogenic properties and a potential for benefits to hu

254 Exogenous compounds that have estrogenic properties can also be found circulating in t

255 Previous studies have shown estrogenic properties for hops, likely due to the presen

256 l growth, which is consistent with the known estrogenic properties of o,p'-DDT and p,p'-DDT.

257 Although hops shows strong estrogenic properties via ERalpha, licorice might have d

258 (BPA), an endocrine-disrupting compound with estrogenic properties, fed to a/a dams harboring A(vy)/a

259 er preventives, especially due to their anti-estrogenic properties.

260 ive oxygen species (ROS)-generating, but non-estrogenic, quinone.

261 Here, we discover an essential role for estrogenic regulation in vertebrate liver development to

262 provide data that support the importance of estrogenic regulation of S6K1 expression in breast cance

263 al prefrontal cortex (mPFC), suggesting that estrogenic regulation of the DH influences mPFC spinogen

264 However, the impairment of estrogenic relaxation was evident after the occurrence o

265 ion, mERalpha signaling is important for the estrogenic response in female mice in a tissue-dependent

266 types are critically involved in the teleost estrogenic response, with the ERalpha:ERbeta ratio being

267 a large set of ER data, accurately predicted estrogenic responses and demonstrated its utility for ch

268 All bisphenol compounds induced estrogenic responses in Tg(ERE:Gal4ff)(UAS:GFP) zebrafis

269 Estrogenic responses were determined using luciferase re

270 te" genes, selected for their involvement in estrogenic responses, and 120 SNPs in reference genes we

271 exposure activity ratios for biological and estrogenic responses, known chemical:gene interactions f

272 to these xenoestrogens may cause deleterious estrogenic responses, such as DNA damage, in susceptible

273 roteins Gs and Gi/o, and mediate non-genomic estrogenic responses.

274 Chemical analysis of the estrogenic samples indicated 2 pesticides (bifenthrin, d

275 compounds that were uniquely present in the estrogenic samples, biologically treated and untreated.

276 ess water (OSPW) was detected with the yeast estrogenic screening assay after fractionation with soli

277 The hypothesis is that in normal tissue the estrogenic SERM activity of a dual AI/SERM could attenua

278 lts indicate that Beclin 1 can down-regulate estrogenic signaling and growth response, and contribute

279 for reproductive state-dependent changes in estrogenic signaling capacity within microdissected brai

280 otein-coupled receptor GPR30 (GPER) mediates estrogenic signaling in breast cancer cells and cancer-a

281 brain-derived estrogens focus on males, but estrogenic signaling in females likely plays important r

282 microdialysis were used to determine whether estrogenic signaling in the mPOA modulates cocaine-induc

283 g chemicals (EDCs) are suspected of altering estrogenic signaling through estrogen receptor (ER) alph

284 tively, these data demonstrate that aberrant estrogenic signaling through the K303R ERalpha mutation

285 one quality are due to either stimulation of estrogenic signaling via isoflavones or through a novel

286 1 (mTORC1) has emerged as a critical node in estrogenic signaling.

287 ry-driven activation of HSCs and put forward estrogenic signalling as an option for mechanical reprog

288 cular mechanisms by which antiandrogenic and estrogenic signals induce penile malformations and demon

289 n combination can inhibit some, but not all, estrogenic signals.

290 lose their ability to respond positively to estrogenic stimulation.

291 and that these projections are sensitive to estrogenic stimulation.

292 experimental tool for the study of putative estrogenic stimuli of breast cancer.

293 anium dioxide (nTiO2) for rapid detection of estrogenic substance (bisphenol A) has been proposed.

294 e again consistent with those of only a weak estrogenic substance.

295 Exposure of male fish to estrogenic substances from wastewater treatment works (W

296 al electrode material for detection of other estrogenic substrate.

297 gistic contributions to the production of an estrogenic transcriptional response.

298 llary study was designed to assess potential estrogenic treatment effects on cognition and mood.

299 Reciprocating the anti-estrogenic tumor suppressor activity of RUNX proteins, i

300 tilus) inhabit river stretches polluted with estrogenic WwTW effluents.