ライフサイエンスコーパス: eukaryotic initiation factor

1 s composed of 13 subunits and is the largest eukaryotic initiation factor.

2 heterogeneous protein complexes such as the eukaryotic initiation factors.

3 complex (TC) with eIF2-GTP, is stimulated by eukaryotic initiation factor 1 (eIF1), eIF1A, eIF3, and

4 ke ER kinase (PERK) and the alpha subunit of eukaryotic initiation factor 2 (eIF-2alpha), as well as

5 During translation initiation the eukaryotic initiation factor 2 (eIF2) forms a ternary co

6 Eukaryotic initiation factor 2 (eIF2) is a G protein cri

7 Eukaryotic initiation factor 2 (eIF2) is a key integrato

8 Phosphorylation of eukaryotic initiation factor 2 (eIF2) is an important me

9 ISR) via sensing amino acid depletion by the eukaryotic initiation factor 2 (eIF2) kinase GCN2.

10 repression of the p53 protein by the CUGBP1-eukaryotic initiation factor 2 (eIF2) repressor complex.

11 Protein translation through eukaryotic initiation factor 2 (EIF2) signaling, a pathw

12 rotein kinase R (PKR), which inactivates the eukaryotic initiation factor 2 (eIF2) translation initia

13 Activated GCN2 phosphorylates eukaryotic initiation factor 2 (eIF2), altering gene-spe

14 ludes an early initiation complex containing eukaryotic initiation factor 2 (eIF2), GTP, and methioni

15 an Obg-family GTPase, has been implicated in eukaryotic initiation factor 2 (eIF2)-mediated translati

16 ough phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2).

17 pt dedicated stress kinases to phosphorylate eukaryotic initiation factor 2 (eIF2).

18 tion of a key translation initiation factor, eukaryotic initiation factor 2 (eIF2).

19 nitiation is regulated by phosphorylation of eukaryotic initiation factor 2 (eIF2-P) that causes decr

20 phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 (eIF2alpha) and inhibits

21 the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) in MEFs in an

22 the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) translation i

23 ated phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

24 ng dephosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

25 t on phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

26 anslation initiation factor alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

27 tion initiation factor, the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

28 responses (AADR) such as phosphorylation of eukaryotic initiation factor 2 (p-eIF2) leading to incre

29 t the hepatic heme-regulated inhibitor (HRI)-eukaryotic initiation factor 2 alpha (eIF2 alpha) kinase

30 y converging at serine-51 phosphorylation on eukaryotic initiation factor 2 alpha (eIF2alpha) and act

31 spond to cellular stress by deactivating the eukaryotic initiation factor 2 alpha (eIF2alpha) or othe

32 PKR's pro-apoptotic role through eukaryotic initiation factor 2 alpha (eIF2alpha) phospho

33 d by attenuating protein translation through eukaryotic initiation factor 2 alpha (eIF2alpha) phospho

34 In 2014, scientists discovered mutations in eukaryotic initiation factor 2 alpha kinase 4 (EIF2AK4)

35 ation with polysomes likewise depends on the eukaryotic initiation factor 2 alpha kinase 4, which ass

36 at AKT1 protein loss led to the induction of eukaryotic initiation factor 2 alpha subunit (eIF2alpha)

37 which can be repressed by phosphorylation of eukaryotic initiation factor 2 alpha-subunit (eIF2alpha)

38 eatic ER kinase, and its downstream effector eukaryotic initiation factor 2 in human leukemia (HL60)

39 orylation of both protein kinase R (PKR) and eukaryotic initiation factor 2 on the alpha-subunit in s

40 hared across the ages, corroborating similar eukaryotic initiation factor 2 phosphorylation responses

41 ts, independent of source of infection, with eukaryotic initiation factor 2 signaling being the most

42 (ER) cisternae, increased phosphorylation of eukaryotic initiation factor 2 subunit alpha (P-eIF2alph

43 nslational arrest through phosphorylation of eukaryotic initiation factor 2 subunit alpha.

44 nitiation factor eIF2alpha (alpha subunit of eukaryotic initiation factor 2), ensuring viral protein

45 hosphorylation of the alpha-subunit of eIF2 (eukaryotic initiation factor 2), which inhibits its guan

46 -like ER kinase)-eIF2alpha (alpha subunit of eukaryotic initiation factor 2)-dependent pathway by Sub

47 bits the translation initiation factor eIF2 (eukaryotic initiation factor 2).

48 trol nonderepressible 2), phosphorylation of eukaryotic initiation factor 2, and increased synthesis

49 sphorylation of PKR and the alpha subunit of eukaryotic initiation factor 2, indicating that K1L and

50 ither protein kinase R, which phosphorylates eukaryotic initiation factor 2, nor oligoadenylate synth

51 e in phosphorylation of the alpha subunit of eukaryotic initiation factor 2, requiring PKR-like endop

52 ated PKR phosphorylates the alpha subunit of eukaryotic initiation factor 2, thereby inhibiting prote

53 ated PKR phosphorylates the alpha-subunit of eukaryotic initiation factor 2, thereby inhibiting prote

54 translational control via phosphorylation of eukaryotic initiation factor 2, which is implicated in l

55 suppresses protein synthesis by inactivating eukaryotic initiation factor 2-alpha (eIF2-alpha), to ex

56 st-in-class, small molecule inhibitor of the eukaryotic initiation factor 2-alpha kinase 3 (EIF2AK3)

57 w "privileged" translation despite inhibited eukaryotic initiation factor 2-guanosine triphosphate-in

58 vent phosphorylation of the alpha-subunit of eukaryotic initiation factor 2.

59 sphorylation of PKR and the alpha subunit of eukaryotic initiation factor 2.

60 mulate and activate Gcn2p phosphorylation of eukaryotic initiation factor-2 (eIF2) and the general am

61 ly of protein kinases that phosphorylate the eukaryotic initiation factor-2 (eIF2) function in transl

62 t environmental stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) rapidly reduces pr

63 site (IRES) whose activity is suppressed by eukaryotic initiation factor 2A (eIF2A; YGR054W).

64 (i)(Met)) pathway but required expression of eukaryotic initiation factor 2A.

65 mal inhibitors enhanced GADD34 stability and eukaryotic initiation factor 2alpha (eIF-2alpha) dephosp

66 to amino acid deficiency, phosphorylation of eukaryotic initiation factor 2alpha (eIF2 approximately

67 kinase 1/2 (ERK1/2 Tyr202/204; +65% +/- 9%), eukaryotic initiation factor 2alpha (eIF2alpha Ser51; -2

68 ed through the translation initiation factor eukaryotic initiation factor 2alpha (eIF2alpha) and the

69 Phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha) controls

70 associated with increased phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha) in the l

71 und in solid tumours, activated the upstream eukaryotic initiation factor 2alpha (eIF2alpha) kinase G

72 R kinase (EIF2AK3)], the ER stress-activated eukaryotic initiation factor 2alpha (eIF2alpha) kinase.

73 mbryonic fibroblasts depleted for individual eukaryotic initiation factor 2alpha (eIF2alpha) kinases,

74 dd34 (damage-inducible protein 34) prolonged eukaryotic initiation factor 2alpha (eIF2alpha) phosphor

75 nt study, we investigated whether increasing eukaryotic initiation factor 2alpha (eIF2alpha) phosphor

76 e previously reported that activation of the eukaryotic initiation factor 2alpha (eIF2alpha) stress p

77 a rudimentary amino acid starvation-sensing eukaryotic initiation factor 2alpha (eIF2alpha) stress r

78 asmic reticulum kinase (PERK) phosphorylates eukaryotic initiation factor 2alpha (eIF2alpha) to atten

79 e of several kinases that phosphorylates the eukaryotic initiation factor 2alpha (eIF2alpha) to inhib

80 SNCEE, we found the translational regulator eukaryotic initiation factor 2alpha (eIF2alpha) was hype

81 f the PERK arm stimulates phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha), resulti

82 g and activation through a process requiring eukaryotic initiation factor 2alpha (eIF2alpha), the tra

83 ses often involve chronic phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha), with de

84 nretinide and bortezomib are mediated by the eukaryotic initiation factor 2alpha (eIF2alpha)-ATF4 sig

85 KR)-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2alpha (eIF2alpha)-dependen

86 nize SAMD9 to prevent granule formation in a eukaryotic initiation factor 2alpha (eIF2alpha)-independ

87 sis, as well as increased phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha).

88 sponse accompanied by the phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha).

89 ion factor 4E (eIF4E) and phosphorylation of eukaryotic initiation factor 2alpha (p-eIF2alpha).

90 dings in this investigation was that PKR and eukaryotic initiation factor 2alpha are phosphorylated u

91 However, Abeta-induced inactivation of the eukaryotic initiation factor 2alpha decreases the synapt

92 ent of its canonical induction downstream of eukaryotic initiation factor 2alpha eIF2alpha phosphoryl

93 However, Abeta-induced inactivation of the eukaryotic initiation factor 2alpha halts the transcript

94 ely, genetically reducing phosphorylation of eukaryotic initiation factor 2alpha in excitatory neuron

95 ed ATF6 translocation and phosphorylation of eukaryotic initiation factor 2alpha in mouse cortical ne

96 The phosphorylation of eukaryotic initiation factor 2alpha increased only at 18

97 general control nonderepressible 2-dependent eukaryotic initiation factor 2alpha phosphorylation and

98 BP1 and G3BP2 cannot form SGs in response to eukaryotic initiation factor 2alpha phosphorylation or e

99 indicative of proliferation such as reduced eukaryotic initiation factor 2alpha phosphorylation, inc

100 ely depleted within a few days, resulting in eukaryotic initiation factor 2alpha phosphorylation, TCR

101 tol-requiring enzyme 1alpha (IRE1alpha), and eukaryotic initiation factor 2alpha phosphorylation.

102 acentas, providing a potential mechanism for eukaryotic initiation factor 2alpha phosphorylation.

103 Increased phosphorylation of eukaryotic initiation factor 2alpha suggests suppression

104 r protein kinase R, which phosphorylates the eukaryotic initiation factor 2alpha to inhibit global pr

105 t to phosphorylate its substrate, eIF2alpha (eukaryotic initiation factor 2alpha), halting cellular t

106 PKR phosphorylates eukaryotic initiation factor 2alpha, a translation initi

107 ulate translation via phosphorylation of the eukaryotic initiation factor 2alpha, and transcription v

108 bles rapid and reversible phosphorylation of eukaryotic initiation factor 2alpha, leading to inhibiti

109 h enables it to phosphorylate its substrate, eukaryotic initiation factor 2alpha, leading to translat

110 in the level of nuclear ATF6, phosphorylated eukaryotic initiation factor 2alpha, nuclear XBP1, and t

111 ylation of the translation initiation factor eukaryotic initiation factor 2alpha, suggesting a novel

112 In addition, increased phosphorylation of eukaryotic initiation factor 2alpha, the translation fac

113 PKR then phosphorylates eukaryotic initiation factor 2alpha, thus inhibiting pro

114 le stress pathways is the phosphorylation of eukaryotic initiation factor 2alpha, which is phosphoryl

115 yzed the effects of NTZ on the regulation of eukaryotic initiation factor-2alpha (eIF2alpha) and its

116 latency is an active process controlled by a eukaryotic initiation factor-2alpha (eIF2alpha) kinase (

117 t results in phosphorylation of the parasite eukaryotic initiation factor-2alpha (eIF2alpha), leading

118 anded RNA-dependent protein kinase (PKR) and eukaryotic initiation factor-2alpha (eIF2alpha).

119 sly shown that phosphorylation of Toxoplasma eukaryotic initiation factor-2alpha (TgIF2alpha) is a co

120 We report that Toxoplasma eukaryotic initiation factor-2alpha (TgIF2alpha) is phos

121 ess marker proteins including phosphorylated eukaryotic initiation factor-2alpha, activating transcri

122 Eukaryotic initiation factor 2B (eIF2B) is the guanine n

123 Eukaryotic initiation factor 2B (eIF2B) plays a key role

124 Eukaryotic initiation factor 2B (eIF2B), a five-subunit

125 n of eIF2alpha and the subsequent control of eukaryotic initiation factor 2B (eIF2B), a multisubunit

126 , and S536-phosphorylated epsilon subunit of eukaryotic initiation factor 2B [eIF2Bepsilon(S536)] is

127 ystem caused by mutations in subunits of the eukaryotic initiation factor 2B complex (eIF2B).

128 Cyclin D1 and the eukaryotic initiation factor 2B epsilon subunit were als

129 (T421/S424)-p70S6K phosphorylation and total eukaryotic initiation factor 2Bepsilon (eIF2Bepsilon) pr

130 n 80S ribosomes and diminishes dependence on eukaryotic initiation factor 3 (eIF3) of reinitiation by

131 in some of the bona fide SG markers, such as eukaryotic initiation factor 3 (eIF3) or eIF4A, or the p

132 The 13-subunit, 800-kilodalton eukaryotic initiation factor 3 (eIF3) organizes initiati

133 ation initiation requires the recruitment of eukaryotic initiation factor 3 (eIF3), but also requires

134 A single 5' UTR m(6)A directly binds eukaryotic initiation factor 3 (eIF3), which is sufficie

135 ntified the N-terminal 91 amino acids of the eukaryotic initiation factor 3 subunit f (N91-eIF3f) as

136 pression encoded the N-terminal 91 aa of the eukaryotic initiation factor 3 subunit f (N91-eIF3f).

137 Eukaryotic initiation factor-3a (eIF3a), a putative subu

138 ith, and relieves the inhibitory function of eukaryotic initiation factor 3f, a repressive component

139 then applied to quantify phosphorylations on eukaryotic initiation factor 3H (eIF3H), a protein integ

140 aintenance in vivo by specifically targeting eukaryotic initiation factor 4A (eIF4A) and interfering

141 carrying a T-DNA insertion in one of the two eukaryotic initiation factor 4A (eIF4A) genes present in

142 anslation initiation by strongly stimulating eukaryotic initiation factor 4A (eIF4A) helicase activit

143 The eukaryotic initiation factor 4A (eIF4A) is a DEAD box he

144 unwind G4 substrates, reminiscent of that of eukaryotic initiation factor 4A (eIF4A) on double-strand

145 This process is powered by the eukaryotic initiation factor 4A (eIF4A), a DEAD-box heli

146 Here we identify the catalytic activity of eukaryotic initiation factor 4A (eIF4A), an ATP-dependen

147 Eukaryotic initiation factor 4A (eIF4A), an ATP-dependen

148 RocA targets eukaryotic initiation factor 4A (eIF4A), an ATP-dependen

149 initiation factors involved in 40S scanning (eukaryotic initiation factor 4A [eIF4A], eIF4B, and Ded1

150 Although the eukaryotic initiation factors 4A/4B/4G can mediate scann

151 PRMT1 methylated the eukaryotic initiation factor 4A1 (eIF4A1) protein, which

152 Here we demonstrate that eukaryotic initiation factor 4a3 (eIF4a3) is involved in

153 ted that knockdown of the EJC core component Eukaryotic initiation factor 4a3 (Eif4a3) results in ful

154 of MET by regulating the phosphorylation of eukaryotic initiation factor 4B (eIF4B) on S406.

155 y brain cytoplasmic (BC) RNAs cooperate with eukaryotic initiation factor 4B (eIF4B) to control trans

156 TOR and the downstream targets S6 kinase and eukaryotic initiation factor 4B.

157 (eIF2alpha Ser51; -20 +/- 5%, P < 0.05) and eukaryotic initiation factor 4E (eIF4E Ser209; +33 +/- 1

158 This step is initiated by eukaryotic initiation factor 4E (eIF4E) (the m7GTP cap-b

159 programs that are sensitive to depletion of eukaryotic initiation factor 4E (eIF4E) and phosphorylat

160 a mediates induction of VEGF expression in a eukaryotic initiation factor 4E (eIF4E) binding protein

161 hosphorylation of p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein

162 ing pathways enhanced polysome occupancy and eukaryotic initiation factor 4E (eIF4E) binding to the 5

163 Surprisingly, Shh promoted eukaryotic initiation factor 4E (eIF4E) expression, but

164 Eukaryotic initiation factor 4E (eIF4E) has long been kn

165 Elevated levels of phosphorylated eukaryotic initiation factor 4E (eIF4E) have been implic

166 The m(7)G cap binding protein eukaryotic initiation factor 4E (eIF4E) is a rate-limiti

167 Elevated eukaryotic initiation factor 4E (eIF4E) levels frequentl

168 h, in turn, regulates phosphorylation of the eukaryotic initiation factor 4E (eIF4E) on Ser-209.

169 Thus, AR suppressed eukaryotic initiation factor 4E (eIF4E) phosphorylation,

170 The eukaryotic initiation factor 4E (eIF4E) plays a central

171 Hypoxic cells switch from eukaryotic initiation factor 4E (eIF4E) to eIF4E2 cap-de

172 te the phosphorylation and activation of the eukaryotic initiation factor 4E (eIF4E), a protein that

173 h biotin and an orthosteric inhibitor of the eukaryotic initiation factor 4E (eIF4E), an enzyme invol

174 of Pea enation mosaic virus (PEMV) binds to eukaryotic initiation factor 4E (eIF4E), but how this af

175 importance is the complex between cap-bound eukaryotic initiation factor 4E (eIF4E), eIF4G, and poly

176 mTORC1 phosphorylates eukaryotic initiation factor 4E (eIF4E)-binding protein

177 ression of constitutively hypophosphorylated eukaryotic initiation factor 4E (eIF4E)-binding protein

178 (CDK1/CYCB1) to directly hyperphosphorylate eukaryotic initiation factor 4E (eIF4E)-binding protein

179 Deletion of the eukaryotic initiation factor 4E (eIF4E)-binding protein

180 /3 (4EBP), which inhibits the translation of eukaryotic initiation factor 4E (eiF4E)-bound mRNAs.

181 ian capped mRNAs is achieved through the cap-eukaryotic initiation factor 4E (eIF4E)-eIF4G-eIF3-40S c

182 NFAT, and translation factors, specifically eukaryotic initiation factor 4E (elf4E) and S6 ribosomal

183 irways have increased phosphorylation of the eukaryotic initiation factor 4E and its partner the 4E-b

184 regulates downstream phosphorylation of the eukaryotic initiation factor 4E at Ser-209.

185 ly depends on transcriptional enhancement of eukaryotic initiation factor 4E binding protein (4E-BP)

186 tion of p70 ribosomal S6 kinase (p70s6K) and eukaryotic initiation factor 4E binding protein 1 (4EBP1

187 Thr-308 and Ser-473), S6 kinase 1 (Thr-389), eukaryotic initiation factor 4E binding protein 1 (Thr-3

188 p70 ribosomal protein S6 kinase 1 [S6K1] and eukaryotic initiation factor 4E binding protein 1) and c

189 protein synthesis by inhibition of eIF4EBPs (eukaryotic Initiation Factor 4E Binding Proteins), regul

190 p70 ribosomal protein S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E-binding (eIF4E-binding)

191 C1) activation as indicated by a decrease in eukaryotic initiation factor 4E-binding 1 (4E-BP1) phosp

192 mTORC1 signaling through p70S6Ks (S6K1/2) or eukaryotic initiation factor 4E-binding protein (4E-BP1/

193 ence of amino acids increased the binding of eukaryotic initiation factor 4E-binding protein (4EBP1)

194 active mutant of the translational repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP

195 ever, adult HSCs had more hypophosphorylated eukaryotic initiation factor 4E-binding protein 1 (4E-BP

196 Here we show that deletion of the eukaryotic initiation factor 4E-binding protein 1 (4E-BP

197 athways of p70 ribosomal S6 kinase (p70S6K), eukaryotic initiation factor 4E-binding protein 1 (4EBP1

198 rEC showed selective increased expression of eukaryotic initiation factor 4E-binding protein 1 (4EBP1

199 d completely suppressed Akt, GSK3beta, mTOR, eukaryotic initiation factor 4E-binding protein 1, and S

200 n of the ribosomal protein S6 kinase and the eukaryotic initiation factor 4E-binding protein 1, two d

201 ng protein interacting protein 2 (Paip2) and eukaryotic initiation factor 4E-binding protein 2 (4E-BP

202 egulator of mRNA translation initiation, the eukaryotic initiation factor 4E-binding protein 2, leads

203 ncrease in ribosomal protein S6 kinase 1 and eukaryotic initiation factor 4E-binding protein-1 (4E-BP

204 The eukaryotic initiation factor 4E-binding protein-2 (4E-BP

205 ned the expression and distribution of mTOR, eukaryotic initiation factor 4E-binding protein1/2 (4E-B

206 via the phosphorylation and inactivation of eukaryotic initiation factor 4E-binding proteins (4E-BPs

207 is controlled by the translation inhibitors, Eukaryotic initiation factor 4E-binding proteins (4E-BPs

208 phorylation of translation initiation factor eukaryotic initiation factor 4E.

209 3 kinase or blocking the interaction between eukaryotic initiation factors 4E (eIF4E) and 4G (eIF4G)

210 survival programs through the regulation of eukaryotic initiation factor 4F (eIF4F) and ternary comp

211 n, HDAC2 induces the formation of the active eukaryotic initiation factor 4F (eIF4F) complex and indu

212 It binds to the eukaryotic initiation factor 4F (eIF4F) complex and prom

213 ion initiation in eukaryotes begins with the Eukaryotic Initiation Factor 4F (eIF4F) complex, made up

214 The eukaryotic initiation factor 4F (eIF4F) is thought to be

215 nce of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F), the key regulat

216 an replace the cellular cap-binding complex, eukaryotic initiation factor 4F (eIF4F), to mediate tran

217 on of 4E-BP1 and increasing the formation of eukaryotic initiation factor 4F (eIF4F), which promote c

218 itiation complex by the cap-binding complex [eukaryotic initiation factor 4F (eIF4F)] at the 5' end o

219 it enhanced imatinib-mediated inhibition of eukaryotic initiation factor 4F induction, and second, i

220 Translation initiation factor eIF4F (eukaryotic initiation factor 4F), composed of eIF4E, eIF

221 In mammals, the direct interaction between eukaryotic initiation factor 4G (eIF4G) and eIF3 is thou

222 ings, we show that the eIF4E-binding site in eukaryotic initiation factor 4G (eIF4G) functions as an

223 ty to activate translation and interact with eukaryotic initiation factor 4G (eIF4G) were required to

224 This mechanism requires eukaryotic initiation factor 4G (eIF4G), subunit of hete

225 rotein kinase B (PKB) and phosphorylation of eukaryotic initiation factor 4G preceded the rise of MPS

226 Binding of the eukaryotic initiation factor 4G to Ded1p interferes with

227 on (UTR) of several mRNA transcripts and the eukaryotic initiation factor 4G.

228 sGAP SH3-domain binding protein 1 (G3BP) and eukaryotic initiation factor 4G.

229 initiation scaffold and "ribosome adaptor," eukaryotic initiation factor 4G1 (eIF4G1) in interphase

230 els of translation initiation factor eIF4G1 (eukaryotic initiation factor 4gamma1).

231 Eukaryotic initiation factor 4GI (eIF4GI) was cleaved ra

232 st cancer potential via up-regulation of the eukaryotic initiation factor 4GI (eIF4GI).

233 oliovirus (PV) 2A protease (2A(Pro)) cleaves eukaryotic initiation factors 4GI and 4GII (eIF4GI and e

234 Hypusine modification of the eukaryotic initiation factor 5A (eIF-5A) is emerging as

235 large decrease in the amount of hypusinated eukaryotic initiation factor 5A (eIF5A) (1/20 of normal)

236 The eukaryotic initiation factor 5A (eIF5A), which is highly

237 tor P (EF-P) is the ortholog of archaeal and eukaryotic initiation factor 5A (eIF5A).

238 eIF5A (eukaryotic initiation factor 5A) is the only known prote

239 usine modification of the translation factor eukaryotic initiation factor 5A.

240 -dependent posttranslational modification of eukaryotic initiation factor 5A.

241 d in the posttranslational activation of the eukaryotic initiation factor 5A.

242 ) in prokaryotes and a related protein named eukaryotic initiation factor 5B (eIF5B) in eukaryotes.

243 tion was defined by a long residence time of eukaryotic initiation factor 5B (eIF5B) on the 80S ribos

244 ing the last step of translation initiation, eukaryotic initiation factor 5B (eIF5B) promotes the 60S

245 Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase tr

246 some synthesis by promoting the recycling of eukaryotic initiation factor 6 (eIF6) in a GTP-dependent

247 Removal of the assembly factor eukaryotic initiation factor 6 (eIF6) is critical for la

248 Eukaryotic initiation factor 6 (eIF6), a highly conserve

249 eading to increased levels of phosphorylated eukaryotic initiation factor alpha, which was required f

250 ightly controlled system that is composed of eukaryotic initiation factors, and which controls the re

251 ion of downstream signaling pathways S6K and eukaryotic initiation factor binding protein 1 (4E-BP1).

252 ied targets of mTORC1 in translation are the eukaryotic initiation factor-binding protein 1 (4E-BP1)

253 and 4E-binding protein; and (4) formation of eukaryotic initiation factor complex 4F, a critical firs

254 ms, their disruption via knockdown of RCK or eukaryotic initiation factor E transporter (eIF4E-T) inc

255 nslation initiation factors to occur, namely eukaryotic initiation factor (eIF) 2 and eIF3.

256 or methionine transfer RNA (Met-tRNAi(Met)), eukaryotic initiation factor (eIF) 2, and guanosine trip

257 protein synthesis via phosphorylation of the eukaryotic initiation factor (eIF) 2alpha and thereby in

258 ly, AMPK activation increased stress-induced eukaryotic initiation factor (eIF) 2alpha phosphorylatio

259 serve to recruit the ribosomal 40S subunit, eukaryotic initiation factor (eIF) 3 and the ternary eIF

260 Eukaryotic initiation factor (eIF) 3j is a subunit of eI

261 Eukaryotic initiation factor (eIF) 4A is a DEAD-box heli

262 Eukaryotic initiation factor (eIF) 4B is known to intera

263 e PI3K/mammalian target of rapamycin and MYC-eukaryotic initiation factor (eIF) 4E pathways, are pred

264 ated protein kinase interacting kinase (MNK) eukaryotic initiation factor (eIF) 4E pathways.

265 ownstream kinase, MNK1, which phosphorylates eukaryotic initiation factor (eIF) 4E.

266 Eukaryotic initiation factor (eIF) 4F binding to mRNA is

267 s have also been directed towards inhibiting eukaryotic initiation factor (eIF) 4F-dependent translat

268 onents of the translation apparatus, such as eukaryotic initiation factor (eIF) 4G (type 2), 40S ribo

269 fect was not due to MNK's known functions as eukaryotic initiation factor (eIF) 4G binding partner or

270 ESs is their ability to bind directly to the eukaryotic initiation factor (eIF) 4G component of the e

271 ranslation; and (iv) LARP1 competes with the eukaryotic initiation factor (eIF) 4G for TOP mRNA bindi

272 zation of the mRNA typically provided by the eukaryotic initiation factor (eIF) 4G/PABP/poly(A) tail

273 on in sensory neurons by converging onto the eukaryotic initiation factor (eIF) eIF4F complex.

274 The universally conserved eukaryotic initiation factor (eIF), eIF1A, plays multipl

275 ty to phosphorylate the alpha subunit of the eukaryotic initiation factor (eIF)-2 complex, resulting

276 et-tRNAi(Met) in a ternary complex (TC) with eukaryotic initiation factor (eIF)2-GTP scans the mRNA l

277 ease translation of IRE-mRNA in vitro; (iii) eukaryotic initiation factor (eIF)4F binds specifically

278 KAR results in enhanced interaction with the eukaryotic initiation factor (eIF)4G and recruitment of

279 The resulting framework reveals that eukaryotic initiation factor (eIF)5B actually accelerate

280 selectively disrupts the interaction between eukaryotic initiation factors (eIF) 4E and 4G, attenuate

281 Two eukaryotic initiation factors, eIF1 and eIF1A, are key a

282 cylated initiator tRNA (Met-tRNA(Met)(i)) by eukaryotic initiation factor eIF2.

283 SGs despite an increased phosphorylation of eukaryotic initiation factor eIF2alpha, a hallmark of st

284 se stresses, different kinases phosphorylate eukaryotic initiation factor eIF2alpha, enabling the tra

285 iciency by modulating the phosphorylation of eukaryotic initiation factor eIF4B, which is critical to

286 which allowed for release and activation of eukaryotic initiation factor eIF4E and subsequent OPN tr

287 pathways and mediate phosphorylation of the eukaryotic initiation factor (eIF4E), a protein that pla

288 , which are known to show high levels of the eukaryotic initiation factor, eIF4E, a potent oncogene.

289 CaMKI-mediated phosphorylation of Ser1156 in eukaryotic initiation factor eIF4GII (4GII).

290 Type I IRESs, 48S complex formation requires eukaryotic initiation factors (eIFs) 1, 1A, 2, 3, 4A, 4B

291 C), consisting of the 40S ribosomal subunit, eukaryotic initiation factors (eIFs) and initiator tRNA

292 translation, requiring only a subset of the eukaryotic initiation factors (eIFs) needed for canonica

293 ng the availability and function of specific eukaryotic initiation factors (eIFs).

294 of protein synthesis that involves multiple eukaryotic initiation factors (eIFs).

295 anced CVB3-induced cleavage of the host cell eukaryotic initiation factor of translation eIF4G in car

296 enzyme system increasing phosphorylation of eukaryotic initiation factor (P-eIF2alpha), which blocks

297 f Plasmodium falciparum eIF2alpha factor, an eukaryotic initiation factor phosphorylated by eIF2alpha

298 omotes dosage-dependent dephosphorylation of eukaryotic initiation factor, potentially inhibiting tra

299 g multiple translation components, including eukaryotic initiation factors, ribosomal large and small

300 r inactivation of the translational molecule eukaryotic initiation factor subunit 2alpha by way of th