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1 n competition experiments, a 50%:50% mixture evolved to 70%:30% (WT/mutant) for A(H1N1) and 88%:12% f
3 s with an initial apolar geometry eventually evolve to a whole gamut of network morphologies based on
5 e ortholog with the highest initial activity evolved to a less-optimal and phenotypically distinct ou
8 volume/low resistance circulation, gradually evolving to a state of circulatory decompensation usuall
9 s the isocyanide to facilitate deprotonation evolving to a zwitterion that traps pai-electrophiles in
10 generation genome-driven clinical trials can evolve to accelerate our understanding of cancer biology
11 extensive mechanisms that gut symbionts have evolved to access nutrients and the potential for unexpe
12 h- and brackish-adapted fauna must emigrate, evolve to accommodate local habitat changes, or are regi
13 ing a rationale for how the LBD binding site evolved to accommodate diverse amino acids, thus laying
14 the novel hypothesis that the unjammed phase evolved to accommodate fluid-like migratory dynamics dur
15 nd its associated translational factors have evolved to accommodate greater participation of proteins
18 analogous mechanisms that have independently evolved to achieve the same goal of stabilizing the epig
19 ggests that the fifth-wave H7N9 viruses have evolved to acquire novel traits with the potential to po
20 bodies, or the cytoskeleton, they have also evolved to act as part of the plant's defense system to
25 y conserved, dedicated molecular network has evolved to allow differentiated cells to re-enter the ce
32 d their hosts can be antagonistic, where TEs evolve to avoid silencing and the host responds by reest
35 lost in the Asian haplotype, which may have evolved to balance the antagonistic RETN effects on path
36 ein, the furin cleavage site and D614G, have evolved to balance virus infectivity, stability, cytopat
38 A successful mutation leading to cancer must evolve to be adaptive, enabling a cancer cell to send a
39 ay in mammals; however, how this pathway was evolved to be functional from its origin is still largel
40 evolution, we found that No Care larvae had evolved to be more cooperative, whereas Full Care larvae
41 dies is key to demonstrating how amino acids evolved to be mostly left-handed in living organisms on
43 ther, in BRAF(V600E)-positive melanoma cells evolved to be resistant to BRAF and/or MEK1/2 inhibitors
45 s a principal component of teeth(1), and has evolved to bear large chewing forces, resist mechanical
46 he potential concern that HPgV will, itself, evolve to become disease-causing by permitting mutant di
47 The island rule predicts that small animals evolve to become larger on islands, while large animals
51 ugh neofunctionalization, the SRG family has evolved to become differentially regulated by the key im
56 e demonstrate the novel strategies that have evolved to both thread an OTU fold and recognize a ubiqu
57 natural product biosynthetic workaround that evolved to bypass a missing precursor and re-establish i
58 re-type-A and pre-type-B, which consequently evolved to cagPAI type-A and type-B, respectively; impor
60 cidation of the mechanism by which H. pylori evolved to carry multiple copies of cagA helps to provid
62 hese highly autophagy-dependent cancer cells evolve to circumvent loss of autophagy by upregulating N
64 (Danaus plexippus), that have independently evolved to colonize plants that produce cardiac glycosid
66 sed frequently in the United States, and has evolved to commonly include paired exchanges, particular
67 coding framework assuming that neurons have evolved to communicate signals optimally given natural s
68 tory coevolution, whereby the nuclear genome evolves to compensate for the deleterious alleles in the
70 gon is a bona fide postprandial hormone that evolved to concurrently and synergistically work with in
73 pressure), the modular perovskite structure evolves to construct crystallographically defined quantu
74 r support the idea that the termination area evolved to contain fork fusion-mediated pathologies.
75 uss how this 'living' set of guidelines will evolve to continually address new developments in neurop
76 emblies of dedicated clock proteins form and evolve to contribute to the generation of clocks that fu
77 strate known as LITTLE ZIPPER 2 (ZPR2)-which evolved to control the activity of the class-III homeodo
78 We propose that the EPFL2 signaling module evolved to control the initiation and regular, equidista
80 damental puzzle of human evolution is how we evolved to cooperate with genetically unrelated stranger
81 veloped in the same maternal environment and evolved to coordinate the timing of germination and the
82 is suggests that phenological plasticity has evolved to cope with fluctuations in the optimum, despit
83 e-body energy homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient s
85 rection of SPECT reconstructions, ultimately evolving to correction techniques that would enable abso
87 maternal) inheritance of cytoplasmic genomes evolved to curtail such selfish replication by minimizin
88 ress histones in a naive system that has not evolved to deal with nucleosomal structures: Escherichia
89 CD) model which predicts that species should evolve to defend territories against heterospecific riva
90 regulatory and often redundant pathways have evolved to detect and respond to human movement, here we
93 echanisms for thick filament activation have evolved to disrupt the interactions that establish the r
95 hanisms not only give clues to how STING has evolved to distinguish between self and foreign, but the
96 that delete or inactivate the transgene may evolve to dominate the vaccine virus population both dur
97 why fungi, rather than unicellular bacteria, evolved to dominate decay of recalcitrant, nutrient poor
103 d although the amygdala and cingulate cortex evolved to enable emotion and cognition in both, an evid
104 herein demonstrate that the NPC, which first evolved to enable the biochemical communication between
105 ding argues that our perceptual systems have evolved to encode environmental stimuli in the most effi
107 of RNAi, cDNA, and chemical libraries, have evolved to encompass a larger biological and chemical sp
108 uits for biological neural routines, but has evolved to encompass the hardware implementation of algo
109 gue that positive emotions such as gratitude evolved to encourage individuals to fulfill cooperative
110 pitopes, suggesting that the antibodies have evolved to engage multiple polymorphic variants of DBP.
111 the ADP-binding function acquired by CxD7L1 evolved to enhance blood-feeding in mammals, where ADP p
113 tuent enzymes in the fusion protein may have evolved to ensure a robust but time-limited cOA-activate
114 mposed by the final structure and might have evolved to ensure efficient, timely folding of a highly
115 Our findings suggest that various PSMs have evolved to ensure fast and efficient biofilm formation t
118 use viral mRNA methyltransferases that have evolved to escape the host's cell immunity response foll
119 longstanding question is how influenza virus evolves to escape human immunity, which is polyclonal an
120 y change in the host antiviral protein as it evolves to escape the effects of viral antagonists.
121 create a persistent global disease burden by evolving to escape immunity induced by prior infections
124 , including Mycobacterium tuberculosis, have evolved to evade or exploit autophagy, but the precise m
126 ns of one-component regulatory proteins have evolved to exert control over RNA-binding ANTAR domains.
134 static and anti-inflammatory activities that evolved to facilitate bloodfeeding, but also modulate th
135 lly concerned supernatural agents culturally evolved to facilitate cooperation among strangers in lar
136 ect chemically mediated behaviours that have evolved to facilitate crucial ecological processes.
137 plication, recruitment, and diversification, evolved to facilitate electron transfer and catalysis at
138 ancestrally, sex-specific immune modulation evolved to facilitate survival of the pregnant person in
139 ntation of the mature neutrophil nucleus has evolved to favor migration through narrow pores as found
140 el also suggests a potential reason why life evolved to favor the enrichment of potassium: so living
141 nificant for understanding how microbes have evolved to fill specific ecological niches within a host
143 of RCO targets reveals that auto-repression evolved to fine-tune RCO activity and that RCO dissects
145 present in the charophycean green algae and evolved to form overlapped and divergent phylogenetic gr
147 a novel gene with unknown origin, oskar has evolved to fulfil a crucial role in insect germ cell for
150 speculate that the caveolae-lipid system has evolved to function as a general stress-sensing and stre
151 owever, it remains unclear why influenza NAs evolved to function as Ca(2+)-dependent tetramers that d
153 dient, we hypothesize that some transporters evolved to harness this 'slip' mechanism to increase sub
155 e energy for growth and maintenance and have evolved to have multiple pathways to produce energy in r
156 to cell viability, molecular chaperones have evolved to help nascent polypeptides fold correctly and
161 This occurs because faster adapting species evolve to hold onto their initial ranges (i.e., monopoli
163 s conserved in On-Off DSGCs; however, it has evolved to include On-Off DSGCs encoding upward and down
164 Trade agreements in the 21st century have evolved to include provisions that affect domestic publi
165 ct of modern life, clinical trials will also evolve to incorporate these tools, meeting participant e
166 lesion synthesis (TLS) polymerases that have evolved to incorporate nucleotides opposite DNA lesions.
170 d shed light on how the plastid proteome has evolved to influence plastid morphology and biochemistry
171 ports the novel concept that M. tuberculosis evolved to inhibit autocrine type I IFN signaling to eva
172 te viral replication.IMPORTANCE Viruses have evolved to inhibit cellular DNA damage response pathways
174 However, how photosynthetic seasonality evolved to its current state, and what role climatic con
175 d domesticated amidase effector 2 (dae2)-has evolved to kill mammalian skin microbes with remarkable
176 speculation that protein sequences may have evolved to limit the population of partially folded stat
179 osition in humans and that secretory IgA has evolved to maintain a diverse and stable gut microbial c
180 ensive compared with the jammed phase, which evolved to maintain a solid-like non-migratory state tha
183 nserved protein quality control process that evolved to maintain secretory pathway homeostasis during
185 ctions with cellular membranes, viruses have evolved to manipulate lipid signaling and metabolism to
187 e favouring nutrient-storage pathways, which evolved to maximize energy utilization and preserve adeq
188 that integral helical membrane proteins have evolved to maximize their fitness with cotranslational f
189 hypothesize that all four ZAP isoforms have evolved to mediate distinct antiviral and/or cellular fu
190 We speculate that the EDTEE motif might have evolved to mediate resistance against retroviruses that
191 tial that elaborate circulatory systems have evolved to minimize diffusion distances within tissue.
192 n elegant strategy that Escherichia coli has evolved to minimize metabolic stress that results from t
194 mate OAS1 as a model for how immune pathways evolve to mitigate costs and observed a surprising frequ
195 yst nematodes are endoparasites that have co-evolved to modify host plants to create sophisticated fe
196 ents, such as peptide toxins, appear to have evolved to modulate physiologically relevant targets by
197 sphatase parameters are consistent with Vip1 evolving to modulate levels of 1-IP(7) and 1,5-IP(8) Ind
200 t sap-feeding insects are widespread, having evolved to occupy diverse environmental niches despite e
201 of NGS data and visualization tools need to evolve to offer the scientific community fast and conven
202 that mechanical activation of these pathways evolved to orchestrate vascular development but also dri
203 rajectories under which an epigenetic switch evolved to outcompete genetic adaptation, shedding light
204 estigate how an IFN-hypersensitive virus can evolve to overcome IFN-beta-mediated blocks targeting th
205 e a common evolutionary origin and that they evolved to parasitise monocot plants from a common dicot
206 arranged in specific network topologies have evolved to perform a diverse array of cellular functions
207 ferent enzymes and even entire pathways have evolved to perform alternative chemical reactions to pro
208 s the optimal treatments of NASH will likely evolve to personalized therapy once we understand the me
209 otility, and show how the outer domains have evolved to play a role not previously found in other bac
210 at least some archaeal histone paralogs have evolved to play distinct and conserved functional roles,
211 is generally assumed that each organism has evolved to possess a unique ribosomal RNA (rRNA) species
212 nt geographic regions revealed that ICP1 has evolved to possess one of two syntenic loci encoding an
213 mitophagy and mitochondrial biogenesis, have evolved to preserve mitochondrial homeostasis under phys
214 the editing domain of I/L/VRSs had primarily evolved to prevent infiltration of Nva into modern prote
215 erlying supergene that determines colour has evolved to prevent phenotypes from "dissolving" into con
216 ve model, tapping perceptual mechanisms that evolved to process physical events in the real world, ma
217 nal centres, the structures in which B cells evolve to produce antibodies with high affinity for vari
218 fter polyploidization, Gossypium hirsutum L. evolved to produce a higher fiber yield and to better su
219 w patterns in more distant teleosts may have evolved to produce a stunningly diverse array of pattern
220 that the filamentous fungus P. graminis has evolved to produce fungal suppressors of RNA silencing a
221 alls short of considering how culture itself evolves to produce indigenous psychologies fitted to par
222 in turn supports the idea that hosts readily evolve to promote host-beneficial defensive microbiomes.
224 ltiple strategies that the immune system has evolved to promote the separation between symbiotic micr
225 to aerobic environment, cellular mechanisms evolved to protect against iron-mediated oxidative damag
226 te-driven priming of mucus barriers may have evolved to protect from subsequent infections with multi
227 sults suggest that antibody-accessible loops evolved to protect key extracellular regions of LptD, bu
228 ss of cell fitness, cellular safeguards have evolved to protect the genome, especially during sensiti
229 ogether, these findings suggest that SOC has evolved to protect the hypertrophic chondrocytes from th
230 eins; their extreme kinetic stability likely evolved to protect the lens from the initiation of aggre
232 We propose that this mechanism may have evolved to provide protection from potentially harmful t
234 example of plasticity of regulatory networks evolving to provide an adapted response in each individu
236 concentrations of anti-rubella IgG have also evolved to rapid, high-throughput binding assays, which
241 G protein-coupled receptors (GPCRs) have evolved to recognize incredibly diverse extracellular li
242 progress that the theoretical descriptor has evolved to reconcile the observed differences between ex
246 We propose that the NRPD1 N-terminus motif evolved to regulate Pol IV function in genome surveillan
247 ndings, we propose that prion-like LCRs have evolved to regulate protein phase behavior and to protec
251 y target 15 EBV promoters that have uniquely evolved to require XPB for activity, providing an additi
252 ry is an evolutionary process by which weeds evolve to resemble domesticated crop plants and is thoug
254 taxa, and several high-altitude natives have evolved to resist the depressive effects of hypoxia on V
255 h as immunological responses might have thus evolved to respond accordingly to dietary surplus and de
256 ts cognition is that signaling pathways that evolved to respond adaptively to food scarcity are relat
258 itch may represent an ancient mechanism that evolved to restrict genetic recombination during sexual
259 ame, our understanding of adipose tissue has evolved to reveal a complex structure with distinct type
261 rily by ADP-glucose pyrophosphorylase, which evolved to satisfy metabolic requirements of a particula
263 jockey family retrotransposons may actually evolve to "selfishly" overreplicate in the genomes that
264 allosteric transcription factors (aTFs) have evolved to sense and respond sensitively to a variety of
265 vely rare in the intestinal epithelium, have evolved to sense and respond to these commensal microbes
267 gnized as emotional expressions because they evolved to signal emotional information in situations th
268 ed faculties, evolved for social bonding, or evolved to signal mate quality - are incomplete or wrong
270 s spread by a few mosquito species that have evolved to specialize in biting humans, yet the precise
271 nd suggest that various GNAT toxins may have evolved to specificaly target other if not all individua
272 ay for them grows, conservation will have to evolve to stay relevant in the age global change-induced
275 lecular machinery for dopamine secretion has evolved to support fast and slow signaling modes, with f
278 that this non-coding-RNA-dependent mechanism evolved to survey the microbial environment of the worm,
279 t is well-understood that many bacteria have evolved to survive catastrophic events using a variety o
281 and plant species, efficient strategies have evolved to synthesize, construct and integrate composite
283 can suggest why (i) mutations are likely to evolve to target it; (ii) inhibitors can straightforward
284 The discovery that one bacterial effector evolved to target ATG16L1's engagement in intracellular
285 appa(2)-cis-P,P-[xant(P(i)Pr(2))(2)]}, which evolve to the dihydride-silyl derivatives IrH(2)(SiR(3))
286 ologies, and next-generation sequencing have evolved to the point where more than two-thirds of conge
287 nding of the unique solutions Plasmodium has evolved to these challenges and discuss the remaining qu
289 ost sulfite reductase suggest that phage Fds evolved to transfer electrons to cyanobacterially encode
291 ll surface; hence, diverse secretion systems evolved to transport the hydrophilic molecules to their
292 NCE Protein shells of viruses (capsids) have evolved to undergo specific changes to ensure the timely
295 aracoccus, Pseudomonas, and Alcaligenes have evolved to use DMF as a sole carbon and nitrogen source
297 racteristics and hearing sensitivity have co-evolved to utilise higher frequencies in forest environm
298 stability, and both DNA and RNA viruses have evolved to utilize epitranscriptomic modifications as a
299 , suggests that Mononegavirales have broadly evolved to utilize LLPS as a common strategy to assemble
300 s, proteins, and other biomolecules and have evolved to withstand large amounts of physical force and