ライフサイエンスコーパス: excess

1 about the potential adverse effects of iron excess.

2 ct the placenta and fetus from maternal iron excess.

3 d by insufficient yield and low enantiomeric excess.

4 resistance, serving as a signal of nutrient excess.

5 cies, or on overweight, obesity, and dietary excess.

6 tio gives only solids, while the addition of excess 15-crown-5 affords a Type II porous liquid.

7 protein in the plasma of veterans displaying excess [(18)F]AV1451 retention.

8 Excess 30-day HF readmissions and mortality are present

9 l quenching (NPQ), a process that dissipates excess absorbed light energy as heat and limits the prod

10 and stabilize unliganded rod opsin, which in excess accelerates degenerative processes in the retina.

11 functions as a molecular rheostat to prevent excess accumulation of MYC protein.

12 he view that L-form division is driven by an excess accumulation of surface area over volume.

13 is greater than TG output, resulting in the excess accumulation of TG.

14 n redundantly to prevent the accumulation of excess acetate.

15 ith these effects on tau, LM11A-31 inhibited excess activation of Fyn kinase and its targets, tau and

16 We provide evidence that excess activity of damage-responsive lung fibroblasts dr

17 on in people with obesity is associated with excess adiposity itself and is not simply a compensatory

18 an estimated 70% of cases are attributed to excess adiposity, there is an increased interest in unde

19 The excess adjusted IRRs were 4.9 (95% CI, 3.5-6.9) for amyo

20 Excess alcohol intake and inherited predisposition may i

21 Both conditions generated excess amacrine cells.

22 obtained quantitatively without the need for excess amine reactant or product purification.

23 Under these conditions, the excess amount of methane stored in the pores of Cr-soc-M

24 T labeling as a decoy reagent to deplete the excess amount of TMT reagent.

25 predictors for mortality, together with base excess and Glasgow Coma Scale.

26 es adaption to both iron starvation and iron excess and is thereby crucial for virulence.

27 complishes determination of the enantiomeric excess and overall amount of a large variety of terpenes

28 ransition metals, high temperatures, reagent excess, and air-sensitive reagents common among the exis

29 nd the world, however, is still supported by excess application of N-rich fertilizers with detrimenta

30 o reinforcing the importance of tissue Na(+) excess, are both mechanistic and clinical.

31 curtail greenhouse gas emissions and capture excess atmospheric carbon dioxide(1,2).

32 essential autophagy gene Atg7 normalizes the excess autophagy and corrects the visual defects caused

33 is formed quantitatively in the presence of excess beta-mercaptoethanol.

34 aternal asthma, vitamin D insufficiency, and excess body mass index (BMI) might share both peripheral

35 e lack of any observed hypertonic skin Na(+) excess, but the lymphatic drainage was impaired (isovolu

36 Thyroid hormone excess, by contrast, accelerates development of the skul

37 s quenching of reactions by the diffusion of excess caging molecules confines synthesis to light patt

38 ermore, we observed that P. ostreatus caused excess calcium influx and hypercontraction of the head a

39 dence increasingly links this advertising to excess calorie intake, understanding of the potential im

40 ients (HQ(s)) > 1; hazard index (HI) ~6; the excess cancer risk (ECR) > 1 x 10(-6)) and, therefore, c

41 d food intake, increased energy expenditure, excess catabolism, and inflammation.

42 In the ER, excess cholesterol acts to reduce cholesterol uptake, pr

43 rol in the PM exceeds a threshold level, the excess cholesterol moves to the endoplasmic reticulum (E

44 When the PM cholesterol exceeds a threshold, excess cholesterol moves to the ER in a process requirin

45 Excess CO(2) and limited H(2) in the feedstock gas is no

46 m encapsulation efficiency demonstrated that excess concentration of initial essential oil reduced th

47 Water deficit and water excess constitute severe stresses that limit crop yield

48 Yet, excess copper is extremely toxic, and is exploited as a

49 t they must also repair the damage caused by excess copper.

50 imple models (and a tool for calculation) of excess COVID-19-related deaths, assuming relative impact

51 vealed binding of cyclic-di-GMP with FlrC(C) Excess cyclic-di-GMP repressed ATPase activity of FlrC(C

52 verwhelming health systems, with substantial excess deaths in lower-income countries resulting from t

53 Age-specific excess deaths in the United States from 1 March to 31 Au

54 ere taken into account, an estimated 217 900 excess deaths occurred from March through August 2020 (1

55 The number of excess deaths, excess deaths per 100,000 people and relative increase i

56 Cause-specific excess deaths were estimated by month and age.

57 a do nothing scenario, we estimated 146 996 excess deaths with an RR of 1.5, 293 991 with an RR of 2

58 The number of excess deaths, excess deaths per 100,000 people and rela

59 I: 2.75, 3.77) and 5.60 (95% CI: 5.24, 5.98) excess deaths, respectively.

60 I: 1.08, 3.61) and 2.41 (95% CI: 1.81, 2.91) excess deaths, respectively; and each 1-ppb increase in

61 ): 33.4, 37.6) and 3.04 (95% CI: 2.17, 3.94) excess deaths, respectively; each 1-part per billion (pp

62 d heart disease caused the most non-COVID-19 excess deaths.

63 In addition, candidate fuel-excess detoxification pathways are evaluated.

64 We found excess differentiation in the CO(2) vent population for

65 of overuse days after discharge were due to excess duration; for UTI, 43.9% were due to treatment of

66 coordinating substrate, which is present in excess during catalysis, on the structure of transient R

67 on high label specificity, making removal of excess dye essential.

68 A method for enantiomeric excess (ee) determination of THFA is presented using a r

69 for the rapid determination of enantiomeric excess (ee) in asymmetric synthetic methodology developm

70 ed with yields up to 92% and an enantiomeric excess (ee) up to 99%.

71 6% and in enantioselectivities (enantiomeric excess (ee)) ranging from 85 to 97%, with diastereoselec

72 This is one of the highest enantiomeric excesses (ee %) and yields reported so far in the litera

73 efore, the detection of l- or d-enantiomeric excesses (ee) of chiral amino acids and sugars could be

74 low Coulombic efficiency of Li anode require excess electrolytes and Li metal, which significantly re

75 photodamage under high light by dissipating excess energy as heat.

76 , such as sweet snacks, as a way of reducing excess energy intake.

77 rs and the mechanisms by which it dissipates excess energy.

78 hus, measurement of sample static structure (excess entropy) provides insight about both strain rate

79 In some cases, introducing excess ethylene can increase reaction rate owing to fast

80 nhibition to some neurons, but an absence of excess excitation.

81 (HSC) are the major cellular contributors to excess extracellular matrix deposition in the diseased l

82 Although accumulation of excess FA in cells is known to be cytotoxic, it is unkno

83 nditure are an attractive approach to reduce excess fat storage and body weight to improve metabolic

84 Furthermore, the role of excess fatty acids (FAs) in perturbing BCAA catabolism a

85 In PDAC, obesity and excess fatty acids accelerate tumor growth and increase

86 Fibrosis is characterized by deposition of excess fibrous material in tissues and organs and is cau

87 NMR time-course experiments with excess formaldehyde in solution show formation of anothe

88 genic adipose tissue is a metabolic sink for excess fuel and is a promising target for the treatment

89 We identify mechanisms through which excess glutamate can negatively influence synaptic plast

90 These disorders result in excess growth of trabecular bone and collagen fibers tha

91 derweight women who older than 35 years with excess GWG had significantly increased odds of preterm b

92 anic compounds with significant enantiomeric excess has been demonstrated.

93 hazard for HF among black men and 11% of the excess hazard among black women was explained by the hig

94 Mediation analyses indicated that 33% of excess hazard for HF among black men and 11% of the exce

95 It is not associated with excess health care utilization or worse short or long-te

96 Our results suggest a mechanism that excess hemin of beta-thalassaemia patients is a signific

97 display severe glucose dependence, caused by excess histones through two separable mechanisms: dampen

98 by forming hydrogen and chelating bonds with excess hydroxyl groups in the hydrogel.

99 erved at higher molar sulfide to metal(loid) excess (Iceland > Yellowstone).

100 To determine the effects of excess IL-18 on virus-induced immunopathology, we infect

101 Thus, excess IL-18 promotes hyperinflammation via an autoinfla

102 ted cytotoxicity, specific viral infections, excess IL-18, and chimeric antigen receptor T-cell thera

103 Seventeen out of 30 MeONPs induced excess IL-1beta production in THP-1 cells.

104 This maturation defect resulted in excess immature neuronal synapses and behavioral abnorma

105 e 125 targeted genes, we also reevaluate DNM excess in 17,426 NDD trios with 6,499 new autism trios.

106 e gut-liver axis under conditions of caloric excess in C57BL/6 mice.

107 nal risk factors did not eliminate the Black excess in combined 30-day HF readmissions or mortality i

108 Excess in composite 30-day HF readmissions and mortality

109 with the pristine state displaying both a Li excess in the transition metal layer and a deficiency in

110 ation in the healthy heart, the dysregulated excess in this pathway underscores asynchronous Ca(2+) r

111 ed phenotypic and biochemical evidence of GH excess including significantly elevated insulin-like gro

112 ERW deployment, including the potential for excess industrial silicate materials (basalt mine overbu

113 r modify their activity or, when released in excess, inflict irreversible damage.

114 riations, enhanced ultraviolet radiation and excess infrared emission-signatures of dusty circumstell

115 nto a "semi-balanced state" characterized by excess inhibition to some neurons, but an absence of exc

116 Here, the effect of excess iron (holo-transferrin 0-2 g/L for 24 and 48 h) o

117 Liver iron excess is observed in several chronic liver diseases and

118 able analysis identified calcified raphe and excess leaflet calcification (defined as more than media

119 Studies estimating excess length of stay (LOS) attributable to nosocomial i

120 Relief from excess levels of non-native proteins by increasing the l

121 Additionally, we found that excess levels of s-Opa1 inhibit fusion activity, as seen

122 Arabidopsis gcn2 mutants was retarded under excess light conditions, implicating the GCN2-eIF2alpha

123 findings reveal a delicate interplay between excess light stress, phytochrome B, ROS production, and

124 We observed D. armatus in light-limiting, excess-light, and sinusoidal-light environments to inves

125 ly variable boundaries during the removal of excess liquid from a flat, hydrophilic surface.

126 This greater forcing also contributed to excess loss from the Greenland and Antarctic ice sheets

127 We observe an excess loss of heterozygosity in lung tumors among ATM L

128 logical role for this glycoprotein, but that excess LRG1 expression in diabetes is pathogenic and con

129 Addition of excess mDAP inhibited growth of this strain, but overexp

130 domains of the spectrin tetramers to release excess mechanical stress.

131 Hypokalemia is associated with excess morbidity and mortality in heart failure.

132 ovides an initial step toward mitigating the excess morbidity and mortality of an incarceration event

133 ous system tumors, which are associated with excess morbidity and mortality.

134 those without CKD, but the magnitude of this excess morbidity and the factors associated with hospita

135 lth problem worldwide and is associated with excess morbidity, mortality, and economic costs associat

136 mol/L remained independently associated with excess mortality (adjusted Hazard Ratio = 3.41; 95%CI, 1

137 displacement was positively correlated with excess mortality (correlation = 0.29).

138 neral population, patients with AR exhibited excess mortality (relative risk of death >1), which rose

139 Excess mortality among people with a history of mental i

140 Calculation of excess mortality and age standardization provide a more

141 ia was independently associated with notable excess mortality and reduced event-free survival, partic

142 but AR + FMR is associated with the largest excess mortality and represents an advanced stage within

143 direct and indirect deaths and estimation of excess mortality are complementary goals that are critic

144 In this study, we quantified excess mortality associated with mental disorders in HIV

145 countries and the timing of any increases in excess mortality between February and September 2020.

146 about age 40 years avoided almost all of the excess mortality due to smoking.

147 Use of ECLS is associated with excess mortality for low- and intermediate-risk neonates

148 We found no excess mortality in the hemodialysis population when com

149 compares the COVID-19 per capita overall and excess mortality rates in the US vs that of 18 OECD coun

150 The excess mortality risk associated with TAPSE <17 mm was n

151 Taking excess mortality risk into consideration, this reduction

152 compared with expected population survival, excess mortality risks of pure AR, AR + OMR, and AR + FM

153 Interventions to reduce excess mortality should address the complex physical and

154 Excess mortality was substantial for severe arrhythmia (

155 ne memory to infectious diseases and prevent excess mortality.

156 ect and indirect) effects of the pandemic on excess mortality.

157 ry, Sarm1(-/-) and DR6(-/-), but not Wld(s) (excess NAD(+)) neurons, are capable of forming spheroids

158 rolyzing adipose triglyceride and generating excess NEFAs.

159 nt in their physiological role of preventing excess negative supercoiling in the genome.

160 ry diseases characterized by the presence of excess neutrophil elastase (NE) activity in tissues, inc

161 Our finding that excess nitrogen can trigger severe bleaching even under

162 ing framework, we tested the hypothesis that excess nitrogen interacts with temperature anomalies to

163 phonons, including limited heat capacity and excess noises via measurements.

164 Most excess non-COVID-19 deaths occurred in April, July, and

165 based engineered solutions aiming to address excess nutrient concentrations in freshwater ecosystems.

166 Floodplain restoration is popular to address excess nutrients, but its ability to enhance photolysis

167 -confirmed cases of typhoid fever lead to an excess of 0.046 perforations per clinical typhoid fever

168 for the first time: mass resolving power in excess of 1 600 000 (at m/z 400), root-mean-square mass

169 ular semiconductors presenting a mobility in excess of 10 cm(2) V(-1) s(-1) .

170 shown to exhibit an average measured gain in excess of 10 dBi and radiation efficiency above 60% over

171 assisted writing with a recording density in excess of 10 Tb in.(-2) .

172 e show that large numbers of cells, often in excess of 100 million per day, continually infiltrate wo

173 2) emitted by human activities, an amount in excess of 2 petagrams of carbon per year (PgC yr(-1)).

174 g(10) reduction of active coronavirus was in excess of 2.2 at a flow rate of 2439 L min(-1) (13.9 mJ

175 Greenland, which display a relative (100)Ru excess of 22 parts per million compared with the modern

176 layer, is able to achieve an NO reduction in excess of 2X that of a platinum group metal (PGM) three

177 We observed pronounced variation (excess of 3-fold) in standardized colon resection ratios

178 te of 2439 L min(-1) (13.9 mJ cm(-2)) and in excess of 3.7 (99.98% removal efficiency) at 684 L min(-

179 same months during 2015 to 2019, for a crude excess of 301 400 deaths (128 100 non-COVID-19 deaths).

180 lectrons in this region can have energies in excess of 7 MeV.

181 viability, namely, requiring temperatures in excess of 850 degrees C.

182 Excess of Abeta42 peptide is considered a hallmark of th

183 Sea level estimates in excess of about 10 metres, however, have been discounted

184 ted terminal alkenes without the need for an excess of alkene and with 2-aminopyridine as an ammonia

185 Fasting and excess of allergen, but not NSAID and exercise, were oth

186 episodes/100 recipients, P < 0.01), with an excess of antibody-mediated rejections.

187 f recently conveyed Mediterranean Water with excess of carbonate and the arrival of subpolar-origin w

188 of Plsp1 decreased when Cpn60 was present in excess of cpSecA1, the stromal motor of the cpSec1 trans

189 tal disorders (NDDs) were identified with an excess of de novo mutations (DNMs) but the significance

190 There is an excess of differentially expressed primate genes near th

191 Independent analyses of enhancers showed an excess of DNVs in associated genes (27 genes versus 3.7

192 it is unclear whether this is mediated by an excess of extracranial vascular disease (i.e. atheroscle

193 tic analyses showed that all subtypes had an excess of genetic risk for Alzheimer's disease (all P >

194 an Africa, this increase amounts to a median excess of HIV deaths, across all model estimates, of 296

195 ampsia cases and 3,854 controls and found an excess of iciHHV-6 in the cases (odds ratio of 2.8, 95%

196 )CuF.HF and (NHC)CuOTf in the presence of an excess of KHF(2) (NHC = IPr, SIPr, IPr(Cl)).

197 ation for over 50 cycles, starting with a 1x excess of Li.

198 Overall, we identified a significant excess of loss-of-function DNMs in genes highly expresse

199 eled tracer is always accompanied by a large excess of non-radioactive tracer known as carrier.

200 atures of these genes: extreme polymorphism, excess of nonsynonymous changes in peptide-binding domai

201 Therefore, an excess of one substrate relative to another must determi

202 5% when cells were coincubated with a molar excess of palbociclib.

203 e Tajima's D for nonsynonymous mutations, an excess of polymorphism, and a spike in the levels of sil

204 Analyses of these genomes reveal an excess of previously undocumented common genetic variati

205 psing analyses to identify loci harboring an excess of rare variants with functional connections to a

206 ection involving the clearance of the lethal excess of ROS molecules through mitophagy, triggered by

207 lkanes in hydrocarbon solvent with a reduced excess of substrate and improved functional group compat

208 an often require directing groups or a large excess of substrate to achieve efficient and selective r

209 account for only a minority of the observed excess of such de novo mutations(1,2).

210 ptations across crossbred animals showing an excess of taurine or indicine ancestry.

211 rignard reagents, in the presence of a major excess of tetramethylenediamine offered the most effecti

212 Early and persistent excess of ThCas diagnosed earlier in the LDCT arm sugges

213 in the presence of bipyridine, or using the excess of the >P(O)H reagent as the P-ligand.

214 glycolysis when the demand for NAD(+) is in excess of the demand for ATP.

215 t high vector expression will not produce an excess of the normal RPE65 protein level.

216 the specific Cotton effect and enantiomeric excess of the parent amine gives potentiality for quanti

217 s good atom economy, requiring only a modest excess of the phosphinoboronate.

218 exhibits a half-life more than ten times in excess of the protein's characterized half-life in mouse

219 sites; they must block the diffusion of the excess of twist through the two binding sites on the DNA

220 nic/likely pathogenic: 18%, P<0.0001) but an excess of variants of uncertain significance (24%, P<0.0

221 o Whites (pathogenic/likely pathogenic: 31%, excess of variants of uncertain significance: 7%).

222 overweight are at high risk if they have an excess of visceral adipose tissue-a condition often acco

223 a pervasive and slow blue-Off system-far in excess of what would be required to satisfy traditional

224 cids (aldonic acids) with large enantiomeric excesses of the same chirality as terrestrial biology re

225 Additionally, prdm8 mutant larvae have excess oligodendrocytes and a concomitant deficit of OPC

226 electivity when mouse fetuses are exposed to excess omega-6 PUFAs in utero.

227 ine the effect of isolated maternal hepcidin excess on pregnancy, in the absence of other confounding

228 -II to cell viability under conditions of Cu excess or deficiency.

229 ene expression, in particular under nutrient excess or deficiency.

230 n HCV replication, which can be perturbed by excess or insufficient Mov10.

231 xcellent yield with very high diastereomeric excess) or cis isomer (with yields and diastereoselectiv

232 Poisson generalized linear model to estimate excess perforations attributed to the typhoid epidemic,

233 Pharmacological control of excess perioperative stress-inflammatory responses has b

234 alphaKlotho, and the lesser known effects of excess phosphate (Pi), or phosphotoxicity.

235 y effective phonon scattering because of the excess point defects and rich microstructures.

236 lutionary signatures including conservation, excess population differentiation, accelerated evolution

237 s possess an immense capacity to accommodate excess positive charge.

238 Excess potassium ions in the Corti fluid are resorbed by

239 evated ROS levels suggest a vulnerability to excess prooxidant loads leading to selective cell death,

240 products skew the diet toward saturated fat, excess protein, cholesterol, lactose, and exogenous horm

241 anism-based inhibitors by comparing hydrated excess proton stabilization during proton transport in M

242 he channel's natural ability to stabilize an excess protonic charge and act as a hydronium mimic.

243 nable the channel to transport and stabilize excess protons, with critical implications for future dr

244 ge number of target structures, but requires excess quantities of suitably protected and activated bu

245 Unlike conventional chemicals, the excess radicals generated in the ELT process are convert

246 le range increases in concentrations of GAS (excess rate [ER] = 9.2%; 95% CI: 4.3%, 14.3%) and DIE (E

247 Excess readmissions and mortality were estimated as the

248 le when using aged tissue in the presence of excess reducing agents.

249 nally, we show that this isotonic skin Na(+) excess, reflecting subclinical oedema, occurs in hyperte

250 nalysis with 4-way decomposition to estimate excess relative risks.

251 - 0.002, and 0.046 +/- 0.003 mole percentage excess, respectively; P < 0.001).

252 tive individuals, respectively, and relative excess risk due to interaction (RERI) 3.34 (95% CI, -1.5

253 int effects were assessed using the relative excess risk due to interaction (RERI).

254 and poor oral health was observed (relative excess risk due to interaction = 1.28, 95% confidence in

255 while protecting these patients against the excess risk for bleeding.

256 hildhood immunisation in Africa outweigh the excess risk of COVID-19 deaths associated with vaccinati

257 mer smokers have about only a quarter of the excess risk of death compared to current smokers.

258 Current international migrants had no excess risk of injury in the past 12 months compared to

259 models, liraglutide was not associated with excess risk of WRF compared with placebo (odds ratio, 1.

260 The excess risk was not explained by age and comorbidities.

261 While no excess risk was observed during the first trimester, the

262 eased risk of dying from CRC, although these excess risks have declined substantially over time.

263 Although excess ROS reduces lifespan by causing extensive cellula

264 When amino acids are in excess, Rsp5 instead uses TORC1-activated Art1 to detect

265 However, excess serine inhibits the growth of B. subtilis.

266 cell) therapy patients without washing away excess serum or detection probes, as is required in ELIS

267 degradation of tubulin mRNAs in response to excess soluble tubulin.

268 s into the cell and, in response, decreasing excess spermidine pools to normal levels.

269 yte chemoattractant protein (CCR2) prevented excess steatosis and inflammation in aging livers but di

270 Hepatic steatosis, the excess storage of intrahepatic lipids, is a rampant clin

271 is short period, numerous factors, including excess stress and inflammatory responses, tumour-cell sh

272 Kidney transplant recipients had excess stroke deaths, particularly at younger ages and w

273 ising F(1)/F(o)-ATPase, is rapid with little excess subunit synthesis, but that assembly of RCI (i.e.

274 ed by sharing common risk factors, including excess sugar consumption and tobacco use, as well as und

275 r, available free volume of the bilayer, its excess surface area, and bending elasticity.

276 atment of rare hereditary disorders of FGF23 excess that cause hypophosphatemic rickets, has also dri

277 n we explore in intact heart under substrate excess the metabolic remodelling associated with cardiac

278 The two major divergence pathways for fuel excess, the glycerolipid/fatty acid metabolism and the p

279 a, or toward starting material recovery when excess thiourea is used.

280 ional clues to mechanistically link nutrient excess to adipose insulin resistance.

281 enylalanine requirements (in the presence of excess tyrosine) during early and late gestation using d

282 Excess unfolded proteins in the ER lumen induce dimeriza

283 ly endocytosed in response to non-iron metal excess, unlike IRT1.

284 to yield gamma-lactones in high enantiomeric excess (up to 99%) using hydrogen peroxide as oxidant an

285 Here, we show that tissue Na(+) excess upon high Na(+) intake is a systemic, rather than

286 benchmark substrates furnishing enantiomeric excess values up to 96%.

287 tion, suggesting it was not dependent on the excess VEGFA produced by the ischemic retina.

288 aring alpha-stereocenters, high enantiomeric excess was maintained during ketone formation, establish

289 lamellar phase is maintained by partitioning excess water into isolated droplets of controlled size a

290 70.39%, and 68.87 to 87.50% for traditional, excess water, and pre-soaking rice methods, respectively

291 cid followed by precipitation by addition of excess water.

292 d they underscore the importance of avoiding excess weight gain before middle age for preventing this

293 ncy virus (HIV)-infected individuals suggest excess weight gain with integrase inhibitor-based antire

294 inhibitors (INSTIs) has been associated with excess weight gain.

295 p=0.121); females 73.2% vs. 90.8% (p=0.005); excess weight loss (EWL) 53.8 +/- 28.1% vs. 57.4 +/- 25.

296 Mean adjusted excess weight loss 3 years after SG amounted to 62.3% (9

297 otal body weight loss of 25.13 +/- 4.44% and excess weight loss of 57.48 +/- 9.64% (P < 0.001).

298 os and excellent diastereo- and enantiomeric excesses when in situ formed [Ir(I)/Tol-SDP] or [Ir(I)/T

299 pectancy has ever been unless nearly 700,000 excess White deaths occur.

300 I find that 400,000 excess White deaths would be needed to equal the best mo