ライフサイエンスコーパス: excessive

1 analyses, the mortality rate does not appear excessive.

2 serotonin (5-HT) in the mammalian brain, and excessive 5-HT signaling is critically implicated in the

3 Both occurred following excessive Ablation Index applications (up to 460 and 480

4 Excessive accumulation of acylcarnitines (ACs), often ca

5 h insulin resistance and is characterized by excessive accumulation of adipose tissue due to chronic

6 me of chronic liver disease characterized by excessive accumulation of extracellular matrix (ECM), is

7 Further, excessive accumulation of Fbw7 substrate c-Myc, increase

8 on by counteracting SWR1, thereby preventing excessive accumulation of H2A.Z.

9 Excessive accumulation of lipids and glucose is central

10 Excessive accumulation of triacylglycerols in humans cau

11 The pathways promoting excessive activation are incompletely understood, with l

12 d is essential for protecting the brain from excessive activation in health and disease.

13 immune response is typically beneficial, an excessive activation leads to cytokine storms, multiple

14 ctive and pro-survival modulating functions, excessive activation of autophagy can also be detrimenta

15 agy is generally protective, uncontrolled or excessive activation of autophagy can be detrimental.

16 Excessive activation of autophagy induces a morphologica

17 utamate transporters are believed to prevent excessive activation of extrasynaptically located recept

18 suggesting that loss of BAT ALK7 results in excessive activation of glucocorticoid signaling upon fa

19 of RA from type II alveolar ECs to suppress excessive activation of innate lymphoid cell (ILC) 2 dur

20 Although excessive activation of the lectin and classical pathway

21 Excessive activation results in intestinal fluid loss du

22 treatment of neurological diseases involving excessive activities of the GluK1 and GluK2 subunits.

23 g GABA(A)R antagonists led to hypothesize an excessive activity of inhibitory circuits in this condit

24 al compensation to hearing loss, rather than excessive adaptation.

25 ls of 2,8-DHA crystal nephropathy induced by excessive adenine intake is unknown.

26 n of Fyn in dMSNs, but not in iMSNs, reduces excessive alcohol but not saccharin intake.

27 Excessive alcohol consumption also remains an intractabl

28 he CeA plays an important role in regulating excessive alcohol consumption and highlight the need for

29 to identify the susceptibility gene loci for excessive alcohol consumption by jointly measuring weekl

30 Molecular mechanisms that prompt or mitigate excessive alcohol consumption could be partly explained

31 the gamma-GT-catalytic metabolic reaction in excessive alcohol consumption is associated with ALDH2,

32 Excessive alcohol consumption leads to overproduction of

33 ; all 24 persons with VLVL and cirrhosis had excessive alcohol consumption or immunosuppression.

34 P are involved in the negative regulation of excessive alcohol consumption.

35 ocrine axis connecting metabolic shifts with excessive alcohol consumption.

36 of mechanisms underlying the development of excessive alcohol consumption.

37 ight into sex-specific mechanisms that drive excessive alcohol drinking.SIGNIFICANCE STATEMENT Estrog

38 Excessive alcohol intake is associated with 5.9% of glob

39 None had prior or current viral hepatitis or excessive alcohol intake.

40 lays a central role in mechanisms underlying excessive alcohol intake.

41 Excessive alcohol use is the third leading cause of mort

42 ssed using ultrasonography in the absence of excessive alcohol use or any other identifiable cause of

43 18,363 Taiwanese people, including 1945 with excessive alcohol use.

44 ient to correct the mitotic errors caused by excessive alpha-tubulin detyrosination independently of

45 a large footprint on a chip and dissipating excessive amount of energy.

46 r skins or into CB6F1 mice that contained an excessive amount of I-Ealpha antigen.

47 The excessive amount of NH(4)Cl in the eluate was removed by

48 o prevent artefacts commonly associated with excessive amounts of Cas9 protein, we have developed a s

49 le-1 (ICAM-1) expressing neutrophils produce excessive amounts of neutrophil extracellular traps (NET

50 Hence, excessive amounts of visceral adipose tissue and of ecto

51 Excessive AMPAR activation leads to diseases such as epi

52 PDE6D), respectively, and BBSome loss causes excessive and ectopic EV production.

53 lia resulted in oligodendrocytes maintaining excessive and ectopic myelin.

54 ded to strike an appropriate balance between excessive and insufficient procedural safeguards.

55 When excessive and uncontrolled, BRCA1 HRR activity promotes

56 despite recognition that these symptoms are excessive and unreasonable.

57 fection, in some cases, the infection can be excessive and/or become chronic, thereby resulting in co

58 rsely, inhibition of VEGF signaling prevents excessive angiogenic sprouting of Slug overexpressing EC

59 on, marked reduction of vascularization, and excessive apoptotic staining in unruptured poorly lutein

60 ing dormant dopaminergic neurons by blocking excessive astrocytic GABA could be an effective therapeu

61 Excessive attention to the animal versus plant binary fo

62 hanisms underlying stress disorders in which excessive avoidance results in maladaptive behaviors.

63 itions in which aversive learning results in excessive avoidance.SIGNIFICANCE STATEMENT Aversive lear

64 However, no evidence for excessive belief updating was found.

65 the gradual oxidation of tannins, decreasing excessive bitterness and astringency in wine.

66 Excessive bone loss occurs in inflammatory disorders suc

67 eads to ectopic formation of osteoclasts and excessive bone resorption, which can be assessed by live

68 ese results implicate chromodomain genes and excessive brain growth in CM1 pathogenesis.

69 an autoinhibitory feedback mechanism against excessive Ca(2+) load during high P(o) activation.

70 Excessive Ca(2+) taken up by mitochondria could lead to

71 A major mechanism of RCD is the excessive calcium loading of mitochondria and consequent

72 endogenous agents can be detrimental and, if excessive, can result in organ and tissue damage.

73 blasts may be more prone to the formation of excessive cellular and extracellular material that are c

74 idy-induced cellular stresses and preventing excessive cellular enlargement during slowed cell cycles

75 -A deposition is promoted by CYCLIN A, while excessive CENP-A deposition is prevented by CYCLIN B, th

76 brain ventricles, is considered a disease of excessive cerebrospinal fluid (CSF) accumulation and the

77 Avoiding excessive chromatographic purification and solid- or liq

78 Furthermore, ATR prevents excessive cleavage of reversed forks by MUS81, revealing

79 t genome architectural protein CTCF prevents excessive clustering of accessible chromatin and decompa

80 n the rate at which susceptible rats develop excessive cocaine-taking behavior.

81 targeting of YAP reversed treatment-induced excessive collagen deposition, leading to enhancement of

82 rial function when the balance is shifted to excessive connectivity.

83 lly laborious and often expensive due to the excessive consumption of reagents.

84 Excessive consumption of sugar has a well-established li

85 tions (up to 460 and 480, respectively) with excessive contact force (30 g on average, with peaks up

86 ies remain elusive, plagued by the issues of excessive contact resistance and large hysteresis in amb

87 , supporting a general deleterious effect of excessive CUB similarity between virus and host.

88 der of the sleep-wake cycle characterized by excessive daytime sleepiness (EDS), cataplexy, nighttime

89 eep disorder marked by chronic, debilitating excessive daytime sleepiness and can be associated with

90 Excessive daytime sleepiness in CD patients may be drive

91 investigated (1) the prevalence of insomnia, excessive daytime sleepiness, anxiety and depression amo

92 ctive age women and are characterized by the excessive deposition of a disorganized extracellular mat

93 itional production method for isots prevents excessive destruction of their color attributes and cont

94 However, observational data suggest that excessive diastolic blood pressure (DBP) lowering might

95 Proper storage of excessive dietary fat into subcutaneous adipose tissue (

96 uencing (scRNA-seq) data effectively without excessive distortion during dimension reduction, we pres

97 t of specific mobile DNA elements that cause excessive DNA damage and genome alterations, which can i

98 Gem cytotoxicity due to the accumulation of excessive DNA damage.

99 tly, we find that the Rad53 kinase restricts excessive DNA unwinding at replication forks by limiting

100 chemical inhibition of DNA polymerases cause excessive DNA unwinding by the replicative DNA helicase,

101 een dynamic portions of DHX15 that restricts excessive domain motions but maintains sufficient flexib

102 data from a large biopsy-controlled study of excessive drinkers recruited from primary and secondary

103 es of alcohol dependence or a consequence of excessive drinking and alcohol exposure.

104 to underlie the transition from moderate to excessive drinking.

105 ysis challenges caused by overdispersion and excessive dropouts in RNA-seq.

106 nation of the impact from overdispersion and excessive dropouts, we propose to apply a robust model,

107 pain emotional systems is triggered by acute excessive drug intake and becomes sensitized during the

108 tion may be a goal-directed choice driven by excessive drug value in negative affective states, a hab

109 e number of binding molecules because of the excessive effective surface area.

110 neously accelerate hole injection and hinder excessive electron injection.

111 ion and could not be reversed by suppressing excessive end resection.

112 owaves as a heat source: intensive labor and excessive energy-consumption.

113 e surveillance and is often neuroprotective, excessive engagement of the system can be deleterious.

114 nders, and Andean highlanders suffering from excessive erythrocytosis (EE); however, the mechanistic

115 Chronic excessive ethanol consumption has distinct toxic and adv

116 lementation of adequate preventive measures, excessive evaluation might lead to undue resource utiliz

117 We show that excessive excision of correctly incorporated nucleotides

118 Noise from excessive excitability at high doses overcomes stability

119 Excessive excitation is hypothesized to cause motoneuron

120 y behaviors (vomiting, use of laxatives, and excessive exercise; 76.3% compared with 56.8%; number ne

121 iption of the FXN gene is silenced due to an excessive expansion of GAA repeats into its first intron

122 We conclude that excessive extracellular ATP-such as in response to infla

123 Increased endothelial permeability leads to excessive exudation of plasma proteins and leukocytes in

124 ntly problematic because of the discovery of excessive false positive (FP) mutations when sequencing

125 Excessive fecal bile acid (BA) loss causes symptoms in a

126 ficits in infants with PWS are replaced with excessive feeding and obesity in childhood through adult

127 ffect is potentially mediated by normalizing excessive firing in the ventral hippocampus without affe

128 However, excessive fission has been associated with multiple neur

129 In contrast, excessive fluoride intake causes dental fluorosis, visua

130 esult in aberrant contractile inhibition and excessive force.

131 calpain-1 knockout in YAC84Q mice alleviated excessive fragmentation of important synaptic proteins.

132 Because excessive fusion of ER tubules will lead to the formatio

133 Here, we find that excessive GABA release from basket cells (BCs) attenuate

134 Excessive generation of oxidants by immune cells results

135 ent cancers require adaptations that prevent excessive genomic alterations from triggering cell death

136 The effect of excessive gestational weight gain (EGWG) is related to a

137 ng metabolic health, the impacts of maternal excessive glucocorticoids (GC) on fetal brown adipose ti

138 rreversibly damaged by long-term exposure to excessive glucose concentrations and lose their ability

139 olecules that regulate lactating MGs with an excessive glucose supply.

140 nd increased cellular ROS accumulation under excessive glucose.

141 Excessive goal theory is supported by dependence severit

142 ducing lower alcohol wines in the absence of excessive grape ripeness remained to be determined.

143 Our data suggest that excessive H(2)S produced by the infected WT mice reduce

144 ntly respond to invading pathogens and avoid excessive harmful immune pathology.

145 l therapy can suppress bacterial infections, excessive heat often damages host cells and lengthens th

146 uartz holder was carefully designed to avoid excessive heating and damaging of the vessel walls.

147 rc6a(Liver-cko) mice on a normal diet showed excessive hepatic fat accumulation and glycogen depletio

148 ite matter abnormality volume (DWMA; diffuse excessive high signal intensity)-for prediction of motor

149 iology of MDD, potentially driven in part by excessive hippocampal gluatmatergic efferents to sgACC.

150 Excessive HR independently and equivalently reduces upri

151 S), and vasovagal syncope (VVS), symptomatic excessive HR occurs.

152 s issue, we investigated the consequences of excessive IL-36 activity in circulating immune cells.

153 Degeneration of photoreceptors caused by excessive illumination, inherited mutations, or aging is

154 ay lead to serious illness as a result of an excessive immune response.

155 ols consistent with either an appropriate or excessive immune response.

156 long chain has been demonstrated to suppress excessive immune responses.

157 as the inflammation subsides, thus avoiding excessive immune suppression.

158 and anti-inflammatory M2 phenotypes promotes excessive inflammation and cardiac injury.

159 r stage, exhaustion and senescence can limit excessive inflammation and prevent immunopathology.

160 e coronavirus 2 (SARS-CoV-2) that results in excessive inflammation and respiratory disease, with cyt

161 e of apoptotic cells by macrophages prevents excessive inflammation and supports immune tolerance.

162 Absence of TIPE results in excessive inflammation and tissue injury after allo-HCT,

163 ially be exploited therapeutically to reduce excessive inflammation in CGD.

164 which NLRP6 function is inhibited to prevent excessive inflammation remain unclear.

165 There were no local or systemic signs of excessive inflammation with normal hematology and serolo

166 adopt regulatory functions that may mitigate excessive inflammation.

167 asite sequestration in organs and consequent excessive inflammatory responses and endothelial damage.

168 ic negative regulatory pathways to attenuate excessive inflammatory responses.

169 iases that can lead to both insufficient and excessive information-seeking.

170 However, excessive innate immune activation can exaggerate diseas

171 hermore, we demonstrate that CSE promotes an excessive innate immune response, suppresses the adaptiv

172 Here, we investigate how excessive innate immune responses to H5N1 impair subsequ

173 diet- and aging-associated hyperinsulinemia, excessive Insr signaling in T regs leads to undesirable

174 lude that social dysfunctions resulting from excessive intake of Delta9-THC in the increasingly avail

175 strate that the deubiquitinase Cyld prevents excessive interleukin 18 (IL-18) production in the colon

176 In the pancreas, excessive intracellular calcium causes mitochondrial dys

177 e a high primary failure rate resulting from excessive inward remodeling, medial fibrosis, and thromb

178 cted in <50% of the samples and only with an excessive irinotecan dose.

179 ficking molecules, and when uncontrolled and excessive it results in various pathological complicatio

180 erminal oxidase, the CydDC complex, shuttles excessive l-cysteine from the cytoplasm to the periplasm

181 ng the electrochemical properties of lithium-excessive layered-oxide electrodes.

182 city to form new blood vessels, resulting in excessive lesion growth, and this process is further tri

183 also be used in pre-clinical research if the excessive level of irreproducibility is to be eliminated

184 Excessive levels of cAMP-calcium signaling can have a nu

185 r rapid cellular communication in the brain, excessive levels of extracellular glutamate can negative

186 he pancreatic islet beta-cell presented with excessive levels of nutrients such as glucose, lipids, a

187 a because of the risk for neurotoxicity with excessive levels.

188 droplets (LDs) are frequently increased when excessive lipid accumulation leads to cellular dysfuncti

189 Treatment with 3P10 reverses excessive lipid oxidation in tumor-bearing mice and prev

190 , the nodule-like aggregates do not arise by excessive local cell proliferation, but by myosin II-dri

191 to underlie exercise intolerance in HFrEF is excessive locomotor muscle group III/IV afferent feedbac

192 have been hampered by unknown biases due to excessive loss to follow-up (LTFU).

193 prevent autoimmune disorders by suppressing excessive lymphocyte activity, but how interstitial moti

194 report a striking loss of synapses driven by excessive microglial pruning early in demyelinating dise

195 Many human diseases are associated with excessive mitochondrial connectivity due to impaired Drp

196 Inhibition of PIM kinases caused excessive mitochondrial fission and significant upregula

197 se cirrhotic patients is not associated with excessive mortality compared with noncirrhotic obese pat

198 This excessive mortality rate demonstrates a high overall inj

199 Moreover, loss of SDE2 or TIM results in an excessive MRE11-dependent degradation of reversed forks.

200 Excessive mucus clogs small airways and reduces pulmonar

201 etion may lead to novel therapeutics against excessive mucus in both human and veterinary patients wi

202 Excessive N deposition on Earth's surface leads to adver

203 ed at many centers, and we hypothesized that excessive narcotics were being dispensed on discharge.

204 binding to reversed forks, thus antagonizing excessive nascent-strand degradation.

205 nd their connections may be important in the excessive negative and blunted positive internal states

206 tors, increased reactive oxygen species, and excessive neuroinflammation.

207 ns of cyclooxygenase-2 might be the cause of excessive neuronal demise in the striatum of Abeta + ET1

208 Thus, LTB4 was the major driver of excessive neutrophilic lung inflammation in CGD mice in

209 nism to protect the bacterial cytoplasm from excessive nitrite toxicity during anaerobic respiration

210 SPR/Cas9 genome editing methods, we isolated EXCESSIVE NUMBER OF FLORAL ORGANS (ENO), an AP2/ERF tran

211 cause wasteful provisioning in sequencing or excessive number of missing sequences.

212 Subsurface contamination due to excessive nutrient surpluses is a persistent and widespr

213 in reward and motivational circuits, whereas excessive opioid consumption counteracts this effect and

214 will highlight new knowledge about causes of excessive or impaired RiBi and the impact of these chang

215 = 2), or death (n = 1) allegedly related to excessive or inadequate monitoring of sedation.

216 Thus, excessive or prolonged IFN production aggravates viral i

217 nd, under certain circumstances, leads to an excessive or uncontrolled immune activation and cytokine

218 osteoprotective function might cause a more excessive osteoclast formation and contribute to greater

219 rosis, and inflammation are characterized by excessive osteocyte death.

220 eduction and a reversible protection against excessive oxidation of the catalytic cysteines in Cd-Msr

221 diac-specific overexpression of GR prevented excessive oxidative stress, apoptosis, and heart failure

222 g was performed on strains with deficient or excessive PE biosynthesis to elucidate the mechanism.

223 tead, they underwent local cell death due to excessive phagocytosis of lysosomes.

224 ngenders systemic phosphotoxicity, including excessive Pi-related vascular calcification and chronic

225 reveal that excessive placental DNA damage in murine models for Corn

226 e but debilitating disorder characterized by excessive plasma triglyceride levels for which treatment

227 affected with COVID-19 are characterized by excessive platelet and neutrophil activation in comparis

228 Deletion of FgMSB3 causes excessive polarized trafficking but blocks the fusion of

229 e transcription factor 1 (Pit-1), leading to excessive PRL secretion.

230 e through deletions and mutations leading to excessive pro-growth signaling pathway activations frequ

231 ptogyrin-3 synaptic vesicle receptor replace excessive production and accumulation of neuropathic pro

232 cumulation and activation of fibroblasts and excessive production of extracellular matrix, which resu

233 s the induction of necroptosis by preventing excessive production of interferon following infection.

234 blood cancers that are characterized by the excessive production of mature myeloid cells and arise f

235 ulted in aberrant JNK pathway activation and excessive production of multiple cytokines and growth fa

236 COVID-19 is characterized by excessive production of pro-inflammatory cytokines and a

237 Infection with SARS-CoV-2 can lead to excessive production of pro-inflammatory cytokines, but

238 Excessive production of reactive oxygen species (ROS) is

239 uitment but caused severe lung pathology and excessive production of the cytokines interleukin (IL)-6

240 Excessive production of uric acid (UA) in blood may lead

241 lts in dysfunctional connective tissues with excessive profibrotic signaling, affecting skin, cardiov

242 atterns observed during aging, including the excessive proinflammatory ligand-receptor interplay, wer

243 Indeed, SCI causes excessive proliferation of bone marrow hematopoietic ste

244 myeloproliferative neoplasm characterised by excessive proliferation of erythroid, myeloid, and megak

245 channel closure, which not only resulted in excessive proliferation of keratinocytes in vitro and in

246 es-associated protein (YAP) and promotes the excessive proliferation of RGPs, together with a subsequ

247 Our results uncover the excessive proton leak as a novel mechanism of age-relate

248 rtic arch PWV on the transmission of harmful excessive pulsatile energy to the brain is not well-unde

249 Light Source synchrotron beamlines, but the excessive radiation damage incurred when using capillari

250 atopoietic cell maintenance, defence against excessive reactive oxygen species and protection from ch

251 ion of dysfunctional mitochondria, producing excessive reactive oxygen species.

252 ts, we develop an efficient method, i.e. the excessive-reductant-directed gelation strategy.

253 we found that five of 10 veterans exhibited excessive retention of [(18)F]AV1451 at the white/gray m

254 ing replication completion while suppressing excessive RF restart by recombination-dependent replicat

255 abundant EDF1 monitors the transcriptome for excessive ribosome density, then triggers a GIGYF2-media

256 sible therapeutic target for alleviating the excessive risk-taking observed across multiple forms of

257 Thus, in the absence of BRCA1, excessive RNF168 expression may drive BIR, and contribut

258 eta production in macrophages by detoxifying excessive ROS levels.

259 egulation leads to mitochondrial fission and excessive ROS production.

260 uisition parameters and decoupling power, no excessive sample heating occurred during acquisition at

261 quently characterized by the accumulation of excessive scar tissue found throughout the neural retina

262 double-mutant cells fail to complete HR, as excessive shieldin activity also inhibits RNF168-mediate

263 's layer is a necessity, presumably to avoid excessive signaling interactions between this layer and

264 , but in the absence of dNTPs, this leads to excessive single-strand DNA that exceeds the protective

265 ts increased (OR 3.24, 95% CI 1.73-6.06) and excessive sleepiness in connection with evening shifts d

266 The most common presenting symptom of OSA is excessive sleepiness, although this symptom is reported

267 d resolution of DNA damage in order to avoid excessive spreading of ubiquitinated chromatin.

268 and ex vivo Last, deletion of Bbeta2 rescued excessive stroke damage associated with dephosphorylatio

269 A notable exception, however, is the excessive succinate accumulation despite reduced succina

270 Excessive sugar intake is now recognized as a key risk f

271 lic awareness of the adverse consequences of excessive sun exposure, modifying sun-seeking behavior i

272 exhibiting a metabolic shift when MGs had an excessive supply of glucose.

273 ells that are ultimately responsible for the excessive synthesis, deposition and remodelling of extra

274 s a critical inhibitory receptor that limits excessive T cell responses.

275 of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cel

276 r-old male patient manifested right eye (RE) excessive tearing, conjunctival injection and pain.

277 ntractility, dysregulation of ERK signaling, excessive TGFbeta1 expression and abnormally-patterned v

278 eptor (TSHR) that act as agonists and induce excessive thyroid hormone secretion, releasing the thyro

279 alancing the primary defensive functions and excessive tissue damage actions.

280 f not timely resolved, neutrophils can cause excessive tissue inflammation and damage.

281 nhibition of PD-1 accelerates Mtb growth via excessive TNF-alpha secretion.

282 nces in the glutamatergic system, leading to excessive, toxic stimulation, have been associated with

283 inostat, tamoxifen and pembrolizumab with no excessive toxicity after progression on a median of five

284 han 5 x 10(7) CART-19 at inducing CR without excessive toxicity.

285 Excessive tumor necrosis factor (TNF) is known to cause

286 g of the neurocognitive processes leading to excessive uncertainty and distrust of past experiences i

287 opose that these phenomena are the result of excessive uncertainty regarding state transitions (trans

288 eryday life, some individuals suffer from an excessive, uncontrolled use of social media despite expe

289 ering incompatibility, low mass loading, and excessive usage of nonactive materials, all of which cau

290 hallenge to animal and human health posed by excessive use of antimicrobials in aquaculture.

291 gs point to the need for caution in avoiding excessive use of general anesthesia in young children an

292 The excessive use of tetracyclines (TCs), a bacteriostatican

293 ong-face (LF) morphology is characterized by excessive vertical facial growth with severe disarrangem

294 t high doses are less efficacious because of excessive vessel pruning and hypoxia.

295 aking into visceral adipose tissue can cause excessive visceral adipose tissue lipolysis independentl

296 Excessive visceral fat accumulation is a primary risk fa

297 ns in Marsileaceae with an increased risk of excessive water loss during drought.

298 male infertility, early growth retardation, excessive weight gain in adulthood, heterotaxia, pre-axi

299 s normalization or imputation to account for excessive zeros or "drop-outs." Here, we extensively ana

300 y of microbial data characteristics, such as excessive zeros, over-dispersion, compositionality, intr