ライフサイエンスコーパス: exchange factor

1 ne exchange factor, betaPIX (Pak interactive exchange factor).

2 hat functions as eIF2's dedicated nucleotide exchange factor.

3 B (eIF2B), a multisubunit guanine nucleotide exchange factor.

4 rones, an Hsp40 (J-protein) and a nucleotide exchange factor.

5 a GTPase activating protein and a nucleotide exchange factor.

6 nding partner beta-PIX, a guanine nucleotide exchange factor.

7 he first identified nuclear Hsp70 nucleotide exchange factor.

8 Sevenless (SOS) is a Ras guanine nucleotide exchange factor.

9 Rho-GTPases effectors and guanine nucleotide exchange factors.

10 d and that Cand1/2 act as substrate receptor exchange factors.

11 ors, such as Hsp40 J-proteins and nucleotide exchange factors.

12 of (at least) three Drosophila Arf6 guanine exchange factors.

13 ylinositol 3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-REX1), a chemotactic Rac guanine ex

14 ylinositol 3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-REX1), a key Gbetagamma chemotactic

15 of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1, also known as RABEX-5) sever

16 lgi brefeldin A-resistant guanine nucleotide exchange factor 1) in four unrelated families with indiv

17 nst brefeldin A-inhibited guanine nucleotide-exchange factors 1 and 2 (BIG1 or BIG2) that activate AD

18 ontraction, including Rho guanine nucleotide exchange factor 2 (GEF-H1, ARHGEF2) and MRTF-A target ge

19 ylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 (PREX2) using the same immortalized hu

20 ion of a single gene, Rap guanine nucleotide exchange factor 3 (Rapgef3), was strongly up-regulated i

21 analysis revealed the Vav guanine nucleotide exchange factor 3 (VAV3), an activator of Rho family GTP

22 ptionally controlling Rap guanine nucleotide exchange factor 3/exchange factor directly activated by

23 nhibitor 2 [ARHGDIB], Rho guanine nucleotide exchange factor 6, angiotensin-II type 1 receptor, endot

24 ated VPS9a, the conserved guanine-nucleotide exchange factor activating Rab5 GTPases, is required for

25 imulated GTPase, and ARL3 guanine nucleotide exchange factor activities.

26 he essential subunits for guanine nucleotide exchange factor activity for Rab1 GTPase.

27 25f, which promote EPAC1 guanine nucleotide exchange factor activity in vitro.

28 We determined that the guanine nucleotide exchange factor activity of DOCK8 is essential for the i

29 onucleotide exchange assay measuring guanine exchange factor activity that can be applied after heat

30 ion independently of Rac1 guanine nucleotide exchange factor activity.

31 its (Galpha), acting as a guanine nucleotide exchange factor and a chaperone.

32 RASGRP1 is an important guanine nucleotide exchange factor and activator of the RAS-MAPK pathway fo

33 on of FAK depends on both guanine nucleotide exchange factor and Tyr(P) GIV signaling as well as on t

34 amics, including numerous guanine nucleotide exchange factors and GTPase-activating proteins.

35 ert with several cochaperones and nucleotide exchange factors and plays an essential role in protein

36 otein complexes acting as guanine nucleotide exchange factors and possibly as tethers, regulating int

37 RAB13 GTPase and the NET1 guanine nucleotide exchange factor, and are regulated by the tumor-suppress

38 roteins including Vav1, a guanine nucleotide exchange factor, and the activation of the mitogen activ

39 l GTPases, their upstream guanine nucleotide exchange factors, and GTPase-activating proteins (GAPs)

40 nd P-Rex1, a Rac-specific guanine nucleotide exchange factor, are fundamental Gbetagamma effectors in

41 n C9orf72, which encodes a predicted guanine exchange factor, are the most frequent genetic cause of

42 n ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Golgi.

43 ies: the ARF GTPases, the guanine nucleotide exchange factors (ARF GEFs) that activate them, and the

44 Arf guanine nucleotide exchange factors (Arf-GEFs) regulate virtually all traff

45 by the SEC7 domain of ARF guanine-nucleotide exchange factors (ARF-GEFs), resulting in the recruitmen

46 A-sensitive ADP-ribosylation factor-guanine exchange factors (ARF-GEFs).

47 se-activating proteins (ArfGAPs) and guanine exchange factors (ArfGEFs) that regulate the activity of

48 ein expression of the Rho guanine nucleotide exchange factor ARHGEF1, MLC20 , MYPT-1 and the actin-se

49 of G(12)/G(13) or the Rho guanine nucleotide exchange factor ARHGEF12 have lost myogenic vasoconstric

50 -protein ARF1 or the ARF1 guanine nucleotide exchange factor, ARNO, by small, interfering RNA or phar

51 re, we demonstrate that the Hsp70 nucleotide exchange factor Bag1 promotes hERG degradation by the ub

52 ike pathway, involving the Rac/Cdc42 guanine-exchange factor beta-PIX/PIX-1 and effector PAK1/PAK-1,

53 and its interaction with the PAK-interacting exchange factor-beta (beta-Pix) are required to reconsti

54 ene (secretion-regulating guanine nucleotide exchange factor; beta=0.0137; P=2.98x10(-)(4)), also ass

55 ng Scrib from its complex with the Rac/Cdc42 exchange factor betaPIX and decreasing the activity of t

56 racting protein (GIT1) and the cdc42 guanine exchange factor, betaPIX (Pak interactive exchange facto

57 and brefeldin A-inhibited guanine nucleotide-exchange factors (BIG1 and BIG2).

58 Nucleotide exchange factor binding instead is barely influenced in

59 Mice lacking Rab-32 or its nucleotide exchange factor BLOC-3 are permissive to S. Typhi infect

60 karyopherin-alpha; the P32 protamine-histone exchange factor bound as well.

61 oteins were classified as guanine nucleotide exchange factors, but recent findings suggest that SmgGD

62 explains how KaiA, by acting as a nucleotide exchange factor, can stimulate phosphorylation of KaiC,

63 We show that Nedd8 conjugation and the SR exchange factor Cand1 have a profound effect on shaping

64 increased intrinsic RhoA guanine nucleotide exchange factor catalytic activity combined with increas

65 protein gephyrin and the guanine nucleotide exchange factor collybistin (Cb).

66 ases, guanosine triphosphatases, and guanine exchange factors) controlled conversion between conforma

67 xon switching in the Arf6 guanine nucleotide exchange factor cytohesin-1 controls Met-dependent cell

68 eceptor that recruits the guanine nucleotide exchange factor dedicator of cytokinesis 4 (DOCK4)(4).

69 1 as an interactor of the guanine nucleotide exchange factor DEF6, and find disrupted binding of muta

70 tion mutations in Rac and guanine nucleotide exchange factors, defects in Rac1 degradation, and mislo

71 ) and is activated by the guanine-nucleotide exchange factor DENND3.

72 omplex as a Rac1-specific guanine nucleotide exchange factor, depleting Rac1 results in the loss of m

73 Instead the mechanism involved the exchange factor directly activated by cAMP 2 (EPAC2).

74 ing Rap guanine nucleotide exchange factor 3/exchange factor directly activated by cyclic adenosine m

75 r RNA (mRNA) encoding the guanine nucleotide exchange factor, DOCK4, mutations of which promote cance

76 Mice lacking the guanine nucleotide exchange factor DOCK8 or CD19 lost IL-10-producing MZ B

77 r work has shown that the guanine nucleotide exchange factor Dock8 plays a role in the migration of a

78 mily protein Cdc42 by the guanine nucleotide exchange factor DOCK8.

79 We identify the guanine-nucleotide exchange factor dPix as an effector of insulin receptor

80 Rho, activated by the guanine-nucleotide exchange factor ECT-2, is upstream of both myosin-II act

81 hat concentrates the RhoA guanine nucleotide exchange factor ECT2.

82 as1 GTPase activator, the guanine nucleotide exchange factor Efc25, by phosphorylating Sts5, a protei

83 osphorylated forms bound with its nucleotide exchange factor eIF2B by electron cryomicroscopy.

84 in turn sequesters the eIF2-specific guanine exchange factor eIF2B to block eIF2 recycling, thereby h

85 the GTPase eIF2 leading to inhibition of its exchange factor eIF2B.

86 ing the interaction of eIF2 with its GTP-GDP exchange factor eIF2B.

87 genous GPR124 and the Rho guanine nucleotide exchange factors Elmo/Dock and intersectin (ITSN).

88 The cAMP-dependent guanine nucleotide exchange factor (EPAC) exchange-protein directly activat

89 pression of the bacterial guanine nucleotide exchange factor, EspT.

90 RHGEF1 is a RhoA-specific guanine nucleotide exchange factor expressed in hematopoietic cells.

91 ccharomyces cerevisiae, the Hsp70 nucleotide exchange factor Fes1 is essential for the degradation of

92 We identified the Cdc42 GTPase exchange factor FGD5 as a downstream target of Tie-2 tha

93 intersectin-1 (ITSN-1), a guanine nucleotide exchange factor for Cdc42, as a novel Golgi component an

94 r common target, eIF2B, a guanine nucleotide exchange factor for eIF2.

95 key scaffold, allowing RIN1 to act as a GTP exchange factor for MFN2-GTPase activation to promote mi

96 ule found in all eukaryotes and serves as an exchange factor for Rab-GTPases to regulate diverse cell

97 of motoneurons via its function as a guanine exchange factor for Rab26, a small GTPase that specifica

98 on beta-Pix (Arhgef7), a guanine nucleotide exchange factor for Rac1 and Cdc42.

99 is mediated by RCC1, the guanine nucleotide exchange factor for Ran, is critical for NCT activity.

100 MAPK pathway, and VAV1, a guanine nucleotide exchange factor for Rho family GTPases that also activat

101 directly interact with a guanine nucleotide exchange factor for Rho family small GTPases, PDZ-RhoGEF

102 ng sequence 2 (ECT2) is a guanine nucleotide exchange factor for Rho GTPases that is overexpressed in

103 SmgGDS is a guanine nucleotide exchange factor for RhoA, but we report here that SmgGDS

104 cellular protein GBF1, a guanine nucleotide exchange factor for small Arf GTPases.

105 thway through Cdc24p, the guanine nucleotide exchange factor for the polarity establishment GTPase Cd

106 between TKS5 and FGD1, a guanine nucleotide exchange factor for the Rho-GTPase CDC42, which is known

107 DOCK proteins are guanine nucleotide exchange factors for Rac and Cdc42 GTPases.

108 ical and conventional Rho guanine nucleotide exchange factors for Rac and Cdc42 that is putatively in

109 IQSEC1-3 encode guanine nucleotide exchange factors for the small GTPase ARF6 and their los

110 is work, we show that the guanine nucleotide exchange factor GBF1, relevant for COPI/Arf1-mediated ce

111 We report that the guanine nucleotide exchange factor GBF1, which activates the small GTPase A

112 ine et al. identify the guanosine nucleotide exchange factor GEF-H1 as critical for shear stress-indu

113 uiting its activator, the guanine nucleotide exchange factor GEF-H1.

114 mediated by P-Rex1, a Rac-guanine nucleotide exchange factor (GEF) aberrantly expressed in breast can

115 Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is a chaperone for se

116 GBA) motif, which confers guanine nucleotide exchange factor (GEF) activity in vitro and promotes G p

117 find that Bem1 directly augments the guanine exchange factor (GEF) activity of Cdc24.

118 usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPCRs.

119 known to be required for guanine nucleotide exchange factor (GEF) activity of VAV proteins.

120 its (Galpha), acting as a guanine nucleotide exchange factor (GEF) and a chaperone.

121 ling in the presence of a guanine nucleotide exchange factor (GEF) and a GTPase activating protein (G

122 structure and stability, guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP

123 Moreover, in vitro guanine nucleotide exchange factor (GEF) assays revealed that I942 and, to

124 d their activation by the guanine-nucleotide exchange factor (GEF) Brag2, which controls integrin end

125 re, we identify a cryptic guanine nucleotide exchange factor (GEF) domain in the OtDUB protein encode

126 BCR recruited a guanidine nucleotide exchange factor (GEF) domain to the fusion kinase to fac

127 TRIO9 contains two guanine nucleotide exchange factor (GEF) domains with distinct specificitie

128 signaling via the RhoA guanidine nucleotide exchange factor (GEF) Ect2 to control local F-actin orga

129 The guanine nucleotide exchange factor (GEF) epithelial cell transforming seque

130 NCE STATEMENT Ric-8b is a guanine nucleotide exchange factor (GEF) expressed in the olfactory epithel

131 ase that functions as a guanosine nucleotide exchange factor (GEF) for ARL3-GDP.

132 localization of Daple, a guanine nucleotide exchange factor (GEF) for Galphai.

133 eIF2B acts as a guanine nucleotide exchange factor (GEF) for its GTP-binding protein partne

134 subunit of the mammalian Mon1-Ccz1 guanidine exchange factor (GEF) for Rab7, required for complex sta

135 have identified DOCK6, a guanine nucleotide exchange factor (GEF) for Rac1 and CDC42, as an independ

136 is likely to behave as a guanine nucleotide exchange factor (GEF) for the RAB-A2a GTPase.

137 iated protein (GIV, aka Girdin) is a guanine exchange factor (GEF) for the trimeric G protein Galphai

138 The C-terminal guanine nucleotide exchange factor (GEF) module of Trio (TrioC) transfers s

139 hanger 1 (PREX1) is a Rac-guanine nucleotide exchange factor (GEF) overexpressed in a significant pro

140 Rab11 traffics the guanine nucleotide exchange factor (GEF) Rabin8 to the centrosome to activa

141 ted nuclear protein (Ran) guanine nucleotide exchange factor (GEF) RCC1.

142 The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) is a key Ra

143 The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) plays a cri

144 In yeast, Arf guanine nucleotide-exchange factor (GEF) Syt1p activates Arf-like protein A

145 Ric-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that activates heterotrimeric G pr

146 cycling pathways, yet the guanine nucleotide exchange factor (GEF) that activates Rab11 in most eukar

147 P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates the small G protein

148 a new subunit of the CCZ1-MON1 RAB7 guanine exchange factor (GEF) that positively regulates RAB7 rec

149 hen detected by RalGDS, a guanine nucleotide exchange factor (GEF) that precipitated the assembly of

150 1 (Tiam1) is a Dbl-family guanine nucleotide exchange factor (GEF) that specifically activates the Rh

151 ed the dual Rac1/RhoA Rho guanine nucleotide exchange factor (GEF) Trio as a critical component of th

152 (leukemia-associated Rho guanine nucleotide exchange factor (GEF)), PDZ-RhoGEF, and p115RhoGEF augme

153 ecycled back to TC by its guanine nucleotide exchange factor (GEF), eIF2B.

154 Multiplexing revealed guanine nucleotide exchange factor (GEF), GTPase-activating protein (GAP),

155 ficking of Rabin8, a Rab8 guanine-nucleotide exchange factor (GEF), to the mother centriole, leading

156 Muk1, a Rab5-specific guanine nucleotide exchange factor (GEF), was identified in our prior globa

157 Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-Ccz1 for Rab7.

158 ributed to a high rate of guanine nucleotide-exchange factor (GEF)-dependent and -independent nucleot

159 he microtubule-associated guanine nucleotide exchange factor (GEF)-H1, is required for the phosphoryl

160 and function and requires guanine nucleotide exchange factor (GEF)-mediated activation of downstream

161 f sevenless 1 (SOS1), rho guanine nucleotide exchange factor (GEF)1 (ARHGEF1), and dedicator of cytok

162 a soluble SNARE (Vam7), a guanine nucleotide exchange factor (GEF, Mon1-Ccz1), a Rab-GDP dissociation

163 rate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors, generating a positi

164 eric GTPase) and DennD1C (guanine nucleotide exchange factor [GEF]) to the IL-17R/Act1 complex in ASM

165 Guanine nucleotide exchange factors (GEFs) activate and consequently stabil

166 e factor (PREX) family of guanine nucleotide exchange factors (GEFs) activates Rho GTPases, leading t

167 y the opposing actions of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (

168 y their specific, cognate guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (

169 phatases (GTPases) by their specific guanine exchange factors (GEFs) and their GTPase-activating prot

170 Guanine nucleotide exchange factors (GEFs) are the initiators of signaling

171 Tiam1 and Trio, which are guanine nucleotide exchange factors (GEFs) for Rac, thereby stimulating Rac

172 proteins are multidomain guanine nucleotide exchange factors (GEFs) for RHO GTPases that regulate in

173 ors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have emerged as critical signall

174 omprehensive screening of guanine nucleotide exchange factors (GEFs) in human bronchial epithelial ce

175 ptic Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) Kalirin and Trio have emerged as

176 1 (ARF1)-GTPase and its effector ARF-guanine-exchange factors (GEFs) of the Brefeldin A-inhibited GEF

177 The action of guanine nucleotide exchange factors (GEFs) on the ADP-ribosylation factor (

178 teraction with activating guanine nucleotide exchange factors (GEFs) or receptor tyrosine kinase-medi

179 TPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulati

180 PIX proteins are guanine nucleotide exchange factors (GEFs) that activate Rac and Cdc42, and

181 ein kinases, Rho family GTPases, and guanine exchange factors (GEFs), as well as the binding domain o

182 ed family of non-receptor guanine nucleotide exchange factors (GEFs), GIV/Girdin, Daple, NUCB1 and NU

183 lled by their regulators; guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAP

184 y of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAP

185 Upon activation by guanine nucleotide exchange factors (GEFs), Rac1 associates with a variety

186 ctors, both effectors and guanine nucleotide exchange factors (GEFs), showed induction of RAB11B bind

187 t the inhibition of Rho guanosine nucleotide exchange factors (GEFs), the enzymes that stimulate Rho

188 Rab11 and Rab8, together with their GDP-GTP exchange factors (GEFs), TRAPP-II and Rabin8, promote re

189 es, whose activation is regulated by guanine exchange factors (GEFs).

190 spatiotemporal control by guanine nucleotide exchange factors (GEFs).

191 he SH3BP5 family of Rab11 guanine nucleotide exchange factors (GEFs).

192 family of Rab-activating guanine nucleotide exchange factors (GEFs).

193 Cdc42 is activated by guanine nucleotide exchange factors (GEFs).

194 TPases is governed by Rho guanine nucleotide exchange factors (GEFs).

195 ther with the ADP ribosylation factor GTPase exchange factors GNOM and BIG3 in regulating PIN polarit

196 ways, involving ubiquitin ligases and GTPase exchange factors/GTPase-activating proteins (GEF/GAP).

197 Guanine exchange factor H1 (GEF-H1), a RhoA activator, is though

198 on and phosphorylation of guanine nucleotide exchange factor H1 (GEF-H1), leading to Ras homolog fami

199 of MT-bound Rho-specific guanine nucleotide exchange factor-H1 (GEF-H1) and was abolished by HDAC6 d

200 y bound to HSPA1L, and the Hsp110 nucleotide-exchange factor HSPH2 preferred HSPA1A.

201 calcium and diacylglycerol-regulated guanine exchange factor I (CalDAG-GEFI), have been reported prev

202 which indicates superiority of a system with exchange factor if substrate receptors bind substrates a

203 ue enables the linking of guanine nucleotide exchange factor-induced Eu(3+)-GTP association to RAS, m

204 Ric-8b, a guanine nucleotide exchange factor, interacts with Galphaolf and can amplif

205 cribe a role for asparagine as an amino acid exchange factor: intracellular asparagine exchanges with

206 ss-of-function mutations in DOCK8, a guanine exchange factor involved in hematopoietic cell migration

207 ization is activated by a guanine nucleotide exchange factor known as Dedicator of cytokinesis 2 (DOC

208 on was independent of Rac guanine nucleotide exchange factors known to regulate T cell activity.

209 argo proteins such as the guanine nucleotide exchange factor Lfc or the small GTPases RagA and Rab3D.

210 sin contractility controlled by RhoA and its exchange factor Lfc.

211 e ADP-ribosylation-factor guanine nucleotide exchange factor, MIN7/BEN1 (HOPM INTERACTOR7/BREFELDIN A

212 substrate receptors is mediated by a protein exchange factor named Cand1.

213 hrough the cAMP-activated guanine nucleotide exchange factor NCS-Rapgef2 in mice.

214 demonstrate that the ER-resident nucleotide exchange factor (NEF) Grp170 plays an important role dur

215 omyces cerevisiae) functions as a nucleotide exchange factor (NEF) to regulate the protein folding ac

216 t shock protein 110 (Hsp110)-type nucleotide exchange factor (NEF).

217 Nucleotide exchange factors (NEFs) play a crucial role in exchangin

218 linos targeting two other guanine nucleotide exchange factors not known to be in the Cdc42/ciliogenes

219 otein that functions as a guanine nucleotide exchange factor of ADP-ribosylation factors (Arfs), is c

220 ect of overproduction of Sse1 - a nucleotide exchange factor of the molecular chaperone Hsp70, and it

221 can interact with C3G, a guanine nucleotide exchange factor of the small GTPase Rap1.

222 heterologously expressed guanine nucleotide-exchange factors or of constitutively active (but not wi

223 We further identify the guanine nucleotide exchange factor P-Rex1 as the primary PIP3-stimulated Ra

224 e catalytic activity of a guanine nucleotide exchange factor (P-REX1) that itself promotes Rac1 GTPas

225 first evidence that a Rho-guanine nucleotide exchange factor plays a critical role in podocytes.

226 tol 3,4,5-trisphosphate (PIP3)-dependent Rac exchange factor (PREX) family of guanine nucleotide exch

227 nal calcium sensor 1 (NCS-1) and the guanine exchange factor protein Ric8a coregulates synapse number

228 e whether the RhoGEF (Rho guanine-nucleotide exchange factor) protein Tiam1 plays a unique role in th

229 hrome c release, while knockdown of the Rab5 exchange factor Rabex-5 impairs both BAX clustering and

230 tional association of nascent RAB13 with the exchange factor RABIF.

231 Several Rac guanine nucleotide exchange-factors (Rac-GEFs) were also up-regulated in TG

232 egulation of Rac-specific guanine nucleotide exchange factors, Rac activation, and HSC fitness restor

233 factor 1 (P-REX1), a chemotactic Rac guanine exchange factor (RacGEF).

234 previously identified the guanine nucleotide exchange factor, RAPGEF5.

235 e triggered by Ras GTPase guanine nucleotide exchange factors (RasGEFs) in general, whereas the role

236 iral techniques, that the guanine nucleotide exchange factor RasGRF2 mediates cocaine self-administra

237 Mice deficient in guanine nucleotide exchange factor RasGRP1 exhibit dysregulated homeostatic

238 The RAS exchange factor RASGRP1 is frequently overexpressed in T

239 Active nuclear import of Ran exchange factor RCC1 is mediated by importin alpha3.

240 lear transport of the Ran guanine nucleotide exchange factor RCC1.

241 r polypeptide substrates, and the nucleotide exchange factors regulate the lifetime of the Hsp70-subs

242 These guanine nucleotide exchange factors regulate the spatiotemporal dynamics of

243 RETATION: AKAP13 is a Rho guanine nucleotide exchange factor regulating activation of RhoA, which is

244 stimulated, Rap1-specific guanine nucleotide exchange factor required to balance Ras and Rap signalin

245 an activator of the eIF2 guanine nucleotide exchange factor, rescues the cell growth, translation, a

246 domain that shares homology with the Guanine Exchange Factor (residues Met164 to Glu231), a Plant Hom

247 a tyrosine residue (Tyr-82) inhibits guanine exchange factor Rgl2-mediated nucleotide exchange of Ral

248 septin filaments, the Rho guanine-nucleotide-exchange factor (RhoGEF) Bud3, and the anillin-like prot

249 Rho guanine-nucleotide exchange factor (RhoGEF) proteins as powerful modulators

250 The Rho-guanine nucleotide exchange factor (RhoGEF) TRIO acts as a key regulator of

251 The Rho guanine nucleotide exchange factor (RhoGEF) Trio promotes actin polymerizat

252 rolled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating protein

253 LC)-beta isozymes and Rho guanine nucleotide exchange factors (RhoGEFs) related to Trio, in a strikin

254 e to prepatterning by Rho guanine nucleotide exchange factors (RhoGEFs), a family of proteins involve

255 Rho GTPases are activated by Rho guanine exchange factors (RhoGEFs), but the RhoGEF(s) required f

256 tream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs).

257 Through its exchange factor role, asparagine regulates mTORC1 activi

258 s efficiently activated in vitro by the Sec4 exchange factor, Sec2.

259 Collybistin (CB) is a guanine nucleotide exchange factor selectively localized to gamma-aminobuty

260 Here we demonstrate that BiP's nucleotide exchange factor - Sil1 - can reverse BiP cysteine oxidat

261 an be stimulated by two different nucleotide exchange factors, Sil1 and Lhs1.

262 The chaperone protein and guanine nucleotide exchange factor SmgGDS (RAP1GDS1) is a key promoter of c

263 The nucleotide exchange factor Son of Sevenless (SOS) catalyzes the act

264 ted by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos).

265 hat recruits Ras-specific guanine nucleotide exchange factor, Son of Sevenless 1 (SOS1), to the plasm

266 disrupt the interaction between KRAS and its exchange factor SOS1, a mode of action confirmed by a se

267 -specific deletion of the guanine nucleotide exchange factors Sos1 and Sos2, which are essential LAT

268 epression of ELMO1, a RAC-activating guanine exchange factor, specifically in cancer stem cells of tr

269 overed that overexpression of the nucleotide exchange factor Sse1 can partially alleviate this toxici

270 GEF18 encodes ARHGEF18, a guanine nucleotide exchange factor that activates RHOA, a small GTPase prot

271 ted by cAMP 1 (EPAC-1), a guanine nucleotide exchange factor that activates the small GTPase Rap-1.

272 hat GIV is a non-receptor guanine nucleotide exchange factor that activates trimeric G proteins in re

273 GBF1 encodes a guanine-nucleotide exchange factor that facilitates the activation of membe

274 a ubiquitously expressed guanine nucleotide exchange factor that functions in signaling pathways reg

275 beta-PIX as a predominant guanine nucleotide exchange factor that interacts with Cdc42 in human podoc

276 ARHGEF28/p190RhoGEF) is a guanine nucleotide exchange factor that is activated downstream of integrin

277 Epac is a cAMP-activated guanine nucleotide exchange factor that mediates cAMP signaling in various

278 alpha inhibits eIF2B, the guanine nucleotide exchange factor that recycles inactive eIF2*GDP to activ

279 anger 1 (P-Rex1) is a Rho guanine-nucleotide exchange factor that was originally discovered in neutro

280 assay, BioID, to identify guanine nucleotide exchange factors that activate Cdc42 in immortalized hum

281 RasGRPs are guanine nucleotide exchange factors that are specific for Ras or Rap, and a

282 d receptors stimulate Rho guanine nucleotide exchange factors that promote mammalian cell migration.

283 ber of the DOCK family of guanine nucleotide exchange factors that regulate cell migration, fusion an

284 in particle (TRAPP) complexes are Rab GTPase exchange factors that share a core set of subunits.

285 b effectors and Rab GEFs (Guanine nucleotide Exchange Factors) that regulate vesicular trafficking.

286 PDZ ligand motif with the guanine nucleotide exchange factor TIAM-1/GEF in a complex with act-4/Actin

287 The Rac1 guanine nucleotide exchange factor Tiam1 mediates an OGD-induced increase i

288 inase (PI3K) and the Rac1 guanine nucleotide exchange factor Tiam1.

289 proteins and signaling through the G protein exchange factor Tiam1.

290 Here, we show the guanine nucleotide exchange factor, Tiam1, and its cognate Rho-family G pro

291 ion with the Rac-specific guanine nucleotide exchange factor Tiam2.

292 drolysis by Hsp70s) and also with nucleotide exchange factors to facilitate many protein-folding proc

293 sine phosphatase LAR, and the RAC1 guanidine-exchange factor TRIO.

294 Here we show that RhoG and its exchange factor, Trio, play a role in the regulation of

295 One such cofactor is the nematode nucleotide exchange factor UNC-23, whose mutation disrupts muscle a

296 e family, member A (RhoA) guanine nucleotide exchange factor, upregulated in human schizophrenia brai

297 Gtr1 and Gtr2, which work downstream of the exchange factor Vam6.

298 e identify the Rho-family guanine nucleotide exchange factor Vav2 in a comprehensive screen for human

299 t the DH domain acts as a guanine nucleotide exchange factor, whereas the PH domain binds to various

300 f active RAS is to target guanine nucleotide exchange factors, which allow RAS to cycle from the inac