ライフサイエンスコーパス: excise

1 st a few hours before their derived IESs are excised.

2 he guanosine nucleoside that is subsequently excised.

3 CI: 96.4%, 100%) targets and reflectors were excised.

4 wing primer by NS5B but are also efficiently excised.

5 cone depth or proportion of cervical length excised.

6 ET-CT imaging and nine (60%) were surgically excised.

7 rs from reduced fitness when the prophage is excised.

8 minant role of UvrD in vivo is to unwind the excised 13-mer from dsDNA and that mutation of uvrD resu

9 In the deletion experiments we excised ~ 15 kilobases of DNA that contained a fragment

10 ctonically juxtaposed along a structure that excised 25 km of crust.

11 Here, we describe how AlkC selects for and excises 3mA using a non-base-flipping strategy distinct

12 Essential for DNA demethylation, TDG excises 5-formylcytosine and 5-carboxylcytosine, derivat

13 dramatically influence the ability of TDG to excise 5fC from DNA, indicating that the chromatin struc

14 nine-DNA glycosylase (OGG1) to recognise and excise 8-oxoG.

15 6, and TPB7 Here, we show that TPB1 and TPB6 excise a small, distinct set of 12 unusual IESs that dis

16 We excised a 32 Kb fragment containing transporter genes an

17 5'-dsDNA exonuclease activity that precisely excises a dinucleotide using an intrinsic 'tape-measure'

18 HEJ and HDR in repairing the chromosome when excising a complete locus.

19 roposed that UNG could cooperate with MMR by excising a second uracil in the vicinity of the U:G mism

20 downstream the stwintron could be skipped by excising a sequence that comprises this stwintron, the n

21 denine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguan

22 MutY glycosylase excises adenines misincorporated opposite the oxidativel

23 these dental diseases were managed mainly by excising affected tissue.

24 strate specificity of Mag1 and found that it excises alkylated bases that are known AlkB substrates.

25 and the complex intervening sequence can be excised alternatively either with one standard splicing

26 tes Ire1, an ER-resident kinase/RNase, which excises an intron from HAC1 mRNA followed by exon-exon l

27 During the budding yeast UPR, Ire1 excises an intron from the HAC1 mRNA and the exon produc

28 Terminase enzymes processively excise and package monomeric genomes from a concatemeric

29 assemble the ESCRT III complex, which helps excise and shed the damaged portion of the plasma membra

30 Analysis of all neoformations (155 excised and 140 in follow-up) confirmed these difference

31 melanoma developed at other sites in 9.9% of excised and 9.4% of resected DN.

32 alone to determine if any gland(s) should be excised and auto-transplanted.

33 n, rats were sacrificed, and the brains were excised and divided into three portions.

34 m fibers, pith cells, and vessels under both excised and in vivo conditions in Laurus nobilis In exci

35 The wall of the type 1 big bubble was excised and its grade of scrolling noted.

36 h clinical and/or IVCM examination that were excised and on follow-up of 12 months or longer for the

37 SE) mediate expected levels of recoding when excised and placed in reporter constructs and thus are a

38 After the final CMR, hearts were excised and processed for water content quantification a

39 d regulate primordial germ cells by actively excising and digesting germ cell lobes.

40 hich move within their 'host' genome through excising and re-inserting elsewhere.

41 Occasionally, ICEs become active, excise, and transmit their DNA to a new recipient, where

42 uctural examination of dislocated lenses and excised anterior capsules was performed.

43 les on the mutant chromosome, we selectively excised approximately 44 kb DNA spanning promoter region

44 ain; 2) midregion C2B-C2C-Fer-DysF, commonly excised as an intact module, with subdigestion to differ

45 le and viable female worms in onchocercomata excised at 36 months.

46 as assessed by histopathological analysis of excised atheroma.

47 neratedin vitroby deriving virus from a self-excising BAC in fibroblasts and repressing RL13 and UL12

48 g the appropriate management of incompletely excised, biopsy-proven, mild and moderate dysplastic nev

49 ntify two enzymes, ABHD17a and ABHD17c, that excise BK channel lipid groups with remarkable precision

50 urthermore, ex vivo spectroscopic studies of excised brain tissues demonstrate that the hand-held spe

51 ed variation in xylem sugar concentration in excised branches; (2) changes in carbon allocation in yo

52 an accurate, reliable method to localize and excise breast lesions with acceptable margin positivity

53 -seven paired diagnostic core and surgically excised breast cancer biopsies obtained from women recei

54 Additionally, the excised breast specimens of the same patients (n = 5) we

55 ned to streamline the analysis of surgically excised breast tissues by collecting and statistically p

56 sylase is a base excision repair enzyme that excises bulky base lesions from DNA.

57 The ends of SB transposons excised by a K248A excision(+)/integration(-) transposas

58 substrates contain a leader sequence that is excised by an N-terminal peptidase C39 domain at a doubl

59 ing sequences can constitute complex introns excised by consecutive splicing reactions.

60 s, which are differentially incorporated and excised by pol and exo activity.

61 cation is avoided after the primer strand is excised by the exonuclease and returned back to the poly

62 h resynthesize DNA after the lesion has been excised by the nucleotide excision repair pathway, while

63 Different classes of introns are excised by the U2-type or the U12-type spliceosomes, lar

64 (from 102 women; average age, 54 years) were excised by using FNA and core biopsies and were collecte

65 A total of 40 pairs of excised cadaver femurs (mean patient age at time of deat

66 d (68)Ga-DOTATATE binding in macrophages and excised carotid plaques.

67 rmed as a secondary treatment in one locally excised case.

68 We examined 71 excised cervical lymph nodes (LNs) from persons with HIV

69 ng enzymes that protect genomic stability by excising chemically modified nucleobases that alter norm

70 actin polymerization in primary cilia, which excises cilia tips in a process we call cilia decapitati

71 The organ of Corti in the excised cochlea was subjected to mechanical and electric

72 alling dynamics in lymphatic endothelium, we excised collecting lymphatic vessels from the popliteal

73 r topical application of PARPi-FL on freshly excised cone biopsy samples, the nuclei of tumor cells e

74 late-onset leaking blebs without cutting or excising conjunctival tissue.

75 asured action potentials from the surface of excised contracting rabbit hearts to assess when sarcole

76 es is proposed to have induced foundering of excised cumulate material at P > 1.2 GPa.

77 DNA glycosylases - enzymes that selectively excise damaged, modified, or mismatched nucleobases.

78 lular DNA repair pathway that recognises and excises damaged DNA bases to help maintain genome stabil

79 Using cells from freshly excised disease tissue from patients with Dupuytren's di

80 itical for function, are folded similarly in excised domains and this oligomeric form of apo fl TIA1,

81 tal polyp(s) that underwent a biopsy or were excised during or after the initial colonoscopy, and obt

82 Here, we show that the genomic DNA that is excised during recombination, the excised signal circle

83 hat are shuttled to the exonuclease site and excised efficiently.

84 Thomas et al. (2016) highlight the value of excising enhancer domains, effectively depleting defined

85 tease digestion and physical dissociation of excised fallopian tubes, epithelial cell precursors were

86 Internal eliminated sequences (IES) are excised, followed by rejoining of MAC-destined sequences

87 Aortic valves that were surgically excised for clinical indications were examined for morph

88 After 8 wk, the brains were excised for further mRNA and protein analysis.

89 ely sacrificed after imaging and aortas were excised for mass spectrometry imaging: Matrix Assisted L

90 multigene DNA units that integrate into and excise from host bacterial genomes.

91 d protein sequencing showed that the NCL was excised from a full-length recombinant substrate, togeth

92 metal(II) halide sheet represents a fragment excised from a single layer of the bulk solid structure,

93 approximately 21-22 nt small RNAs which are excised from a stable hairpin-like secondary structure.

94 rial function in brain tissue biopsy punches excised from anatomically defined brain structures, incl

95 Environmental Aux3 can be readily excised from and integrated into the genome via site-spe

96 Urinary bladders were excised from C57BL6/J mice and the DSM was removed by fi

97 Guanine-rich sequences that are excised from damaged genomic DNA are proposed to enter t

98 B dependent gene expression, prior to 8-oxoG excised from DNA.

99 A analogues that were not excised from duplex DNA as efficiently as predicted by c

100 annel-activating effects in membrane patches excised from HEK-293 cells.

101 a more physiological environment, membranes excised from HEK293 cells of neuronal origin, would reve

102 l pruritogens in dorsal root ganglia neurons excised from NC/Nga mice after termination of the studie

103 Therefore, we examined airways freshly excised from newborn non-CF pigs and CF pigs before seco

104 We compare this to a monomeric unit excised from oligomeric FP, which is also dysfunctional

105 e was further investigated on breast tissues excised from prophylactic mastectomy specimens.

106 significantly incorporated but also readily excised from RNA, which may explain its limited efficacy

107 Abeta is a neurotoxic peptide excised from the amyloid-beta precursor protein (APP) by

108 ongitudinal strips of myocardial tissue were excised from the epicardial left ventricular free walls

109 unocomplexes on the test line can further be excised from the test-strip for subsequent off-line meas

110 ed this prediction in mesorectal lymph nodes excised from total mesorectal excision specimens of pati

111 ere visualised around O. volvulus in nodules excised from untreated patients but not in nodules from

112 occal cassette chromosome mec (SCCmec), that excises from and inserts site-specifically into the stap

113 cholerae, TLCPhi, which integrates into and excises from the dif site of the primary chromosome of i

114 lification due to a translocatable unit (TU) excising from an IS26-flanked pseudo-compound transposon

115 PLEs parasitize the lytic phage ICP1, excising from the bacterial chromosome, replicating, and

116 n is required, and this most likely requires excising gastric tissue.

117 xtracts, BER and NER activities co-exist and excise Gh and Sp DNA lesions, suggesting that the relati

118 novel genome editing techniques that safely excise HIV provirus from cells, Tre, an engineered versi

119 D8 immunohistochemistry images of surgically excised hormone receptor-positive breast and colorectal

120 is of living tumor-bearing animals and fresh excised human breast tissue revealed abundance of NAD(P)

121 The technique is demonstrated using excised human ovary and fallopian tube specimens imaged

122 this study, we performed IVPT studies using excised human skin (in vitro) and harmonized in vivo hum

123 helper 17 response was stimulated in freshly excised human skin resulting in significantly upregulate

124 rate penetration of the aptamer into freshly excised human skin using two different fluorescent label

125 plasmids (pCMVbeta and pEGFP-N1) into viable excised human skin.

126 This concept is probed using excised human stratum corneum exposed to aqueous solutio

127 kely to occur in humans because when freshly excised human surgical samples were treated with the flu

128 y increasing the mechanical extensibility of excised hypocotyl segments.

129 al DNA glycosylase that protects its host by excising ICLs derived from azinomycin B (AZB), a potent

130 s and cavernous malformations are surgically excised if accessible, while hemorrhagic dural arteriove

131 with reporter genes that can be subsequently excised improves recovery of edited alleles by an order

132 ved for Merlin-BAC, from which the vector is excised in derived viruses; however, propagation in epit

133 inal inflammation in mice in which Tbx21 was excised in IL-17-producing or Rag1-expressing cells is i

134 Conjunctival lesions were excised in toto using a standard "no-touch technique" by

135 long terminal repeats and the Gag gene, are excised in vivo, resulting in elimination of integrated

136 ANO1 currents in excised inside-out patches activated by 270 nM Ca(2+) at

137 and purified Gbetagamma proteins applied to excised inside-out patches inhibited TRPM3 currents, ind

138 , including specific guide RNAs (gRNAs), can excise integrated human immunodeficiency virus type 1 (H

139 emonstrated configuration, two alternatively excised internal introns, overlapping by one G, disrupt

140 nscription and splicing lead to a paucity of excised intron in the cold, levels of relaxase mRNA are

141 nificance, including a family of full-length excised intron RNAs, subsets of which correspond to mirt

142 Contrary to the common belief that excised introns are rapidly degraded, we found that, in

143 Thus, excised introns function within the TOR growth-signallin

144 , thereby enhancing fidelity, and to release excised introns in a manner coupled to spliceosome disas

145 Here we describe 34 excised introns in Saccharomyces cerevisiae that-despite

146 y degraded, we found that, in six cases, the excised introns were maintained intact in the cells.

147 nt RPR from degradation, the typical fate of excised introns.

148 and thereby release suboptimal substrates or excised introns.

149 The spliceosome excises introns from pre-mRNAs in two sequential transes

150 that cut on either side of the gene drive to excise it.

151 used data linkage to capture all surgically excised keratinocyte carcinomas arising within the cohor

152 tacks the 3'SS to produce mature mRNA and an excised lariat intron.

153 the present comparative study, we conducted excised larynx experiments to investigate this hypothesi

154 analyses of natural vocalizations, motorized excised larynx experiments, tensile material tests and h

155 Herein, we have demonstrated that excised leaf disc has both radical scavenging activity a

156 (PSII) to rapidly increasing temperatures in excised leaf segments of juvenile rice plants.

157 correlated with pathogenicity test data from excised-leaf assays for three isolates of Colletotrichum

158 Using an excised-leaf-assay, the three points were inoculated wit

159 owed by histopathology and flow cytometry of excised leaflets.

160 lfate application caused stomatal closure in excised leaves and peeled epidermis.

161 Furthermore, studies using excised leaves report weaker effects than those with int

162 eity was entirely associated with surgically excised lesions (I(2) = 78%) rather than those managed w

163 ence interval [CI]: 26%, 32%) for surgically excised lesions and 5% (95% CI: 4%, 8%) for lesions mana

164 defined as agreement with histopathology for excised lesions or clinical diagnosis for nonexcised les

165 d clinical and pathologic characteristics of excised lesions were assessed.

166 At subgroup analysis of surgically excised lesions, the pooled upgrade rate was 42% (95% CI

167 nd corresponding histological examination of excised lesions.

168 of arylamine N-acetyltransferases (NATs) in excised liver samples was examined using eighteen Spragu

169 Three to 5 weeks after sacrifice, excised livers were imaged with micro-CT and histologic

170 We have analyzed 13 excised lung specimens from infants (age < 1 year) with

171 Further experiments using mouse models and excised lung tissue identified contributors that drive a

172 to collect mechanical test data from freshly excised lung, obtained from both Sprague-Dawley rats and

173 A lower number of excised lymph nodes was independently associated with wo

174 ries amongst women, the percentage of cervix excised may correlate more accurately to risk than absol

175 Data from 82 freshly excised melanocytic lesions clinically suspected of mela

176 The excised membranes were gently moved in a 2.2 intraocular

177 as then exposed to the extracellular face of excised membranes, and transmembrane currents were monit

178 lease activity of replicative DNA polymerase excises misincorporated nucleotides during DNA synthesis

179 Excising more than 22 lymph nodes and a co-diagnosis of

180 al LE rates on univariate analysis, but only excising more than 22 lymph nodes remained to be signifi

181 -patch nerve fiber recordings in the acutely excised mouse crista ampullaris of the semicircular cana

182 the DNA This active site can accommodate and excise N3-methylcytosine (3mC) and N1-methyladenine (1mA

183 we were surprised to find that T7 replisome excised nearly 7% of correctly incorporated nucleotides

184 Of the 155 excised neoformations with a histopathologic diagnosis,

185 >40% of drugs were retained in the dermis of excised neonatal porcine skin up to 24h post-MN applicat

186 insertion profiles (into a skin simulant and excised neonatal porcine skin) were confirmed by texture

187 -or been restricted to biophysics studies of excised neurons probed with cryogenic or bulky detectors

188 All excised nodal packets (n = 36) were assayed for (99m)Tc

189 The median number of excised nodes was 21 (interquartile range, 16-27).

190 Women aged 18 years or older with completely excised non-low-risk ductal carcinoma in situ were rando

191 ExoN excises nucleotide mismatches at the RNA 3'-end in vitro

192 trongest effects were >20 prior skin cancers excised (odds ratio 8.57, 95% confidence interval [95% C

193 hese damages by capturing and sequencing the excised oligomer released during repair.

194 The single-stranded excised oligomers are ligated to adapters and re-immunop

195 Alternatively, the excised oligomers containing DNA damage, especially thos

196 The DNA damage in the excised oligomers is then reversed by enzymatic or chemi

197 In this protocol, the excised oligomers, generated in the nucleotide excision

198 epend on repair/removal of the damage in the excised oligonucleotides, and thus it is applicable to e

199 s, or caused membrane breakdown; however, in excised outside-out patches, Ag NPs activated Gd(3+) -se

200 tains genome integrity during replication by excising oxidized bases from single-stranded DNA (ssDNA)

201 Excised patch clamp recordings from nuclear membranes of

202 nt rundown and less outward rectification in excised patch, we found that the channel shifted its ion

203 (2), applied to the intracellular surface of excised patches sped up TMEM16A current rundown to nearl

204 ocker glibenclamide in both intact cells and excised patches.

205 Freshly excised patient thyroids with varying fibrotic and malig

206 ite-specific DNA recombination reaction that excises phage lambda from the chromosome, the bacterial

207 The Gd content of excised placentae and fetuses was measured, using induct

208 from rehydration and water-release curves on excised plant material, but the underlying tissue-specif

209 ed micro PET/CT and histological analysis of excised plaque.

210 None of the excised plaques was shown to contain cells (macrophages,

211 arity metrics were determined from ablations excised postmortem.

212 prostatectomy and intraoperative CLI of the excised prostate.

213 or silence astrocyte HIV reservoirs, without excising proviral DNA, will likely lead to detrimental n

214 mice using Osterix (Osx)-Cre as a driver to excise Ptpn11 floxed alleles.

215 optically mapped action potentials (APs) in excised rabbit hearts to test the hypothesis that hypoxi

216 s were made from ANF dendrites using acutely excised rat cochlear preparations of different ages afte

217 epair (HDR), resulting in replacement of the excised region with a donor template carrying the wild-t

218 Two types of Ribonuclease H (RNase H) excise ribonucleotides when they form part of the DNA st

219 Excised right atrial appendages were analyzed histologic

220 highlight that estimates of capacitance from excised samples should be interpreted with caution, as c

221 rate the capture and conjugative transfer of excised SCCmec.

222 However, histological studies of the excised sclera revealed no scleral architectural changes

223 When combined with a self-excising selection cassette, COIN provides highly effici

224 NA that is excised during recombination, the excised signal circle (ESC), forms a complex with the re

225 We demonstrate this method for excised single neurons from marine worm and squid, and t

226 Tumor relapse in patients with initially excised skin squamous cell carcinomas (SCC) is character

227 reoperative lymphoscintigraphic detection or excised SLNs was higher with superficial than deep injec

228 Excised SNs were histopathologically assessed and consid

229 n DNA repair glycosylases that recognize and excise some of the same base lesions.

230 d by the Cas1-Cas2 adaptation complex, which excises spacer-sized fragments and channels them for ins

231 performed on the margins of intact, freshly excised specimens from 83 patients undergoing BCS and on

232 rd the healthy surrounding tissue on freshly excised specimens from the oral cavity.

233 nd Toll-like receptor 4 (TLR4) in surgically excised specimens from the patients and mice with fungal

234 examination of tissue biopsies or surgically excised specimens in biological and clinical laboratorie

235 "free" ICG group, ex vivo evaluation of the excised specimens revealed that 14 SNs removed under ePL

236 he free-ICG group, ex vivo evaluation of the excised specimens revealed that 14 SNs removed under ePL

237 etwork of S. cerevisiae and, more generally, excised spliceosomal introns can have biological functio

238 e compartments for capillary water refill in excised stems but rarely under in vivo conditions, (2) h

239 parison, microtomography images collected on excised stems showed that applied pressures of much grea

240 and in vivo conditions in Laurus nobilis In excised stems supplied with water, water uptake exhibite

241 In excised stems that were sealed, fiber and pith refilling

242 Our data show that embolism removal in excised stems was driven by water droplet growth and was

243 lementation with a functional SsrA in the P2-excised strain completely restores the growth defects in

244 The mass was excised surgically at 89 days of life, and the patient h

245 ed changes can be made to modify, ablate, or excise target genes.

246 e the second US city to implement a beverage excise tax (1.5 cents per ounce).

247 association of the first penny per ounce SSB excise tax in the United States, in Berkeley, California

248 ia in 2017, the implementation of a beverage excise tax on sugar-sweetened and artificially sweetened

249 We recovered thousands of circularly excised Tc1/mariner-type transposable elements and high

250 on of the substrate stereoselectivity of the excised TE domain.

251 AZT(R) RT did not excise terminal nucleotides more frequently than WT, and

252 s multiple DNA processing events required to excise the cross-link from chromatin and resolve the sta

253 ke nicks 5' to the mispair, allowing Exo1 to excise the mispair.

254 of these proteins were encoded by mRNAs that excise the NP1-regulated MVC intron immediately upstream

255 TDG can excise the oxidative products 5fC and 5caC, initiating b

256 e loop driven by an electro-surgical unit to excise the transformation zone) was done under local ana

257 In another set of experiments, we excised the aorta from control and diabetic animals, and

258 to the evolution of definitive mesoderm, we excised the gene using CRISPR/Cas9 in the diploblastic c

259 t CRIPSR-mediated genome editing efficiently excised the mutant exon 23 in dystrophic mice, and immun

260 by Tat during the course of viral infection excises the designated segment of the integrated viral D

261 lycosylase NEIL1, efficiently recognizes and excises the highly mutagenic imidazole ring-opened AFB1-

262 Ung excises the U base created by the deaminase, forming an

263 rom a single-strand break 5' to the mispair, excising the mispair.

264 hen the muscles covering the lch5 organ were excised, the slow relaxation was absent, and the fast re

265 Inteins are parasitic genetic elements that excise themselves at the protein level by self-splicing,

266 grade were surveilled and the remainder were excised, then 97.4% (37 of 38) of malignancies would hav

267 oofreading, mis-incorporated nucleotides are excised through the 3'-5' exonuclease activity of the DN

268 threat are three types of glycosylases that excise thymine from G.T mispairs, including thymine DNA

269 Most of the excised tissue samples displayed histological characteri

270 administering the peptides ex vivo (i.e., to excised tissue) or in vivo (in animals), using antagonis

271 sis of hearing loss based upon findings from excised tissue, thus suggesting a promising druggable et

272 ing cancer in histology slides made from the excised tissue.

273 f the tissue analysis, and are restricted to excised tissue.

274 There is a need to image excised tissues during tumor-resection procedures in ord

275 phenotyping (QMP) of the surface of freshly excised tissues to determine the presence of disease.

276 kinetics were assessed in whole tadpoles and excised tissues using gamma spectroscopy, and temporal c

277 e have greatly extended OCT imaging depth in excised tissues while maintaining a simple and low cost

278 rchitectures of collagen-based scaffolds and excised tissues.

279 The number of lesions needed to excise to rule out a melanoma was 2.4.

280 ological status of the margins of the tissue excised to treat cervical precancer.

281 Vertebrate DNA crosslink repair excises toxic replication-blocking DNA crosslinks.

282 strand breaks (DSB) and the joining of newly excised transposon ends with target DNA.

283 Indeed, the 3,000 bp flanking the excised transposons can contain over 10 times more mutat

284 The results show that the excised TTAA hairpin intermediate and the TTAA target ad

285 or cancer cells found at the boundary of an excised tumor mass, are a significant problem in the man

286 ve prostate carcinoma cells in a hydrogel or excised tumor xenografts from mice were placed into prim

287 As seen on open abdomen and excised tumors views and confirmed by optical radiant ef

288 Additionally, the excised tumors were scored for inflammatory cell infiltr

289 gic details were missing for a proportion of excised tumors.

290 roids, in mouse tumor models in vivo, and in excised tumors.

291 nuclear human uracil DNA glycosylase (hUNG2) excised two uracil lesions spaced 10-80 bp apart in a si

292 The lesion was excised under local anaesthesia and reported to be a con

293 ial and human DNA glycosylases Nei and NEIL1 excise unhooked psoralen-derived ICLs in three-stranded

294 restriction enzyme (restriction glycosylase) excises unmethylated bases from its recognition sequence

295 the requirement for additional surgeries to excise unremoved cancer tissue or alternatively in the r

296 traction of an inflated and axially extended excised vessel provides broader information, both passiv

297 e ability of the tag to measure vibration in excised whiskers in a flume in response to laminar flow

298 The tumor was excised with 4-mm margins from the visible edge of the l

299 s a "second order intron" which must then be excised with a fourth splicing event.

300 yocardial oxygenation and KATP activation in excised working rabbit hearts remains unknown.