ライフサイエンスコーパス: excitable

1 Dynamic actin networks are excitable.

2 age, a time point when these cells are most excitable.

3 ormally inhibit fear extinction, become more excitable.

4 enic BLA principal neurons, making them less excitable.

5 The RIMs become less excitable.

6 constitute a general module for establishing excitable actin dynamics in other cellular contexts.

7 of NKCC1, significantly decreases the hyper-excitable action of GABAA receptor signaling and restore

8 To make this photopigment excitable again,all-trans-retinal must be reisomerized t

9 dult striatal astrocytes into iDANs that are excitable and correct some aspects of motor behavior in

10 medial entorhinal cortex neurons are highly excitable and exhibit a supralinear input-output functio

11 ) are expressed in a diverse variety of both excitable and inexcitable cells, with functional propert

12 Similar dysfunction in other excitable and long-lived cells including neurons is asso

13 a(2+) ions are key second messengers in both excitable and non-excitable cells.

14 Ion channels play fundamental roles in both excitable and non-excitable tissues and therefore consti

15 signaling molecules that play roles in both excitable and nonexcitable cell types and with or withou

16 The extracellular potential of excitable and nonexcitable cells with respect to ground

17 enerally expressed at the plasma membrane of excitable and nonexcitable cells.

18 piking behavior, despite being intrinsically excitable and receiving visuotopically organized synapti

19 Pancreatic beta cells are electrically excitable and respond to elevated glucose concentrations

20 -124-induced neurons (miNs) are functionally excitable and uncommitted toward specific subtypes but p

21 t, with the Purkinje cells being most easily excitable and ventricular cells requiring the highest ir

22 fic chemosensory receptors, are electrically excitable, and modulate serotonin-sensitive primary affe

23 Neurons more active will be more excitable, and thus more responsive to external inputs.

24 Although not electrically excitable, astrocytes display a complex repertoire of in

25 represent a filamentous actin molecule as an excitable automaton network (F-actin automaton).

26 Excitable behavior arising from positive feedback in Cdc

27 ABA)-mediated inhibition and leads to type I excitable behavior characterized by a continuous decreas

28 s the most complete simulation of a piece of excitable brain matter to date.

29 a bright, engineered, orange-red FP that is excitable by cyan light.

30 singlet oxygen production capability and be excitable by light illuminations with deep tissue penetr

31 The nanoparticles are excitable by red light and emit in the near-infrared spe

32 ory pyramidal neurons is to render them more excitable by reducing the spike afterhyperpolarization a

33 l cellular process particularly important in excitable cell activities such as hearing.

34 Collectively LOTUS-V extends the scope of excitable cell control and simultaneous voltage phenotyp

35 Whether nonexcitable cells may modulate excitable cell function or even contribute to AP conduct

36 s an important but potentially toxic role in excitable cell function.

37 ng variation can be applied to models of any excitable cell.

38 maintain high input resistance in these non-excitable cells also requires the K(+) channel subunits

39 annels (Kv) are responsible for repolarizing excitable cells and can be heavily glycosylated.

40 teins in biology, regulating the activity of excitable cells and changing in diseases.

41 channel Orai regulates Ca(2+) entry into non-excitable cells and is required for proper immune functi

42 In humans, ICG labels excitable cells and is routinely visualized transdermall

43 (BK-type) channels, abundantly distribute in excitable cells and often localize to the proximity of v

44 roteins that generate an action potential in excitable cells and play an essential role in neuronal s

45 er for extracellular electrical recording of excitable cells and tissues thus providing a valid alter

46 Given that excitable cells are arranged in interconnected networks,

47 ds used to assess the electrical activity of excitable cells are often limited by their poor spatial

48 Since the Ca2+ dynamics inside the excitable cells are spatiotemporal while the membrane vo

49 ral patterns of resting potentials among non-excitable cells as instructive cues in embryogenesis, re

50 nd their relation to the normal functions of excitable cells as well as pathophysiology.

51 suppression of high-frequency discharges of excitable cells by local anesthetics (LA) is largely det

52 ion flux and generate electrical signals in excitable cells by opening and closing pore gates.

53 er increase or decrease in calcium influx in excitable cells can be associated with BD.

54 ctrophysiology beyond canonical electrically excitable cells could yield exciting new findings.

55 Potassium (K(+)) exits electrically excitable cells during normal and pathophysiological act

56 hannels, CaV, regulate Ca(2+) homeostasis in excitable cells following plasma membrane depolarization

57 Ion channels in excitable cells function in macromolecular complexes in

58 Electrically excitable cells harness voltage-coupled calcium influx t

59 istently, cell-specific ablation of dopamine-excitable cells in dorsal, but not ventral, striatum inh

60 versely, optogenetic stimulation of dopamine-excitable cells in dorsal, but not ventral, striatum sub

61 oral dynamics induced by any neuron or other excitable cells in the animal.

62 urrounding myocytes, suggesting that the non-excitable cells in the scar closely follow myocyte actio

63 is unique to neurons or also occurs in other excitable cells is currently unknown.

64 CaV1 function and suggests a means by which excitable cells may dynamically tune CaV activity.

65 The excitable cells of Dictyostelium discoideum show traveli

66 t drives action potential generation in many excitable cells of the brain, heart, and nervous system.

67 t signaling pathways control the activity of excitable cells of the nervous system and heart, and are

68 In many species, excitable cells preserve their physiological properties

69 sequences of such activity in the setting of excitable cells remains the central focus of much of the

70 In non-excitable cells stromal interaction molecule 1 (STIM1) i

71 high frequency oscillating magnetic field on excitable cells such as neurons are well established.

72 nd viability impairment in aggregate-exposed excitable cells such as peripheral neurons and cardiomyo

73 mparable with those found in compartments of excitable cells such as the postsynaptic density and jux

74 Corticotrophs are excitable cells that receive input from two hypothalamic

75 Corticotrophs are excitable cells that receive input from two hypothalamic

76 In excitable cells these channels are composed of the ion-f

77 nnels fine-tunes the electrical signaling in excitable cells through an internal timing mechanism tha

78 current inhibition that is widely present in excitable cells through modulation of ion channels by sp

79 late action potentials into Ca(2+) influx in excitable cells to control essential biological processe

80 brane potential and regulate the response of excitable cells to various stimuli.

81 dulating the firing patterns of electrically-excitable cells using surface plasmon resonance phenomen

82 Ventricular myocytes are excitable cells whose voltage threshold for action poten

83 een resting V(mem) and the physiology of non-excitable cells with implications in diverse areas, incl

84 ns, genes that function in multiple types of excitable cells, and genes in the signaling pathway of t

85 vascular smooth muscle tissue, electrically excitable cells, and some tumors.

86 tion potential activity across many types of excitable cells, and the activity of L-, N-, P/Q- and R-

87 mbrane proteins that play essential roles in excitable cells, and they are key targets for antiepilep

88 can yield [Ca(2+)](Cyt) oscillations in non-excitable cells, and, under certain conditions, the ER-m

89 ost of hair cells, as well as those of other excitable cells, are still immature.

90 nd light-sensitive ion currents operating in excitable cells, e.g. cardiomyocytes or neurons.

91 In electrically non-excitable cells, for example epithelial cells, this is a

92 es in physiological processes, especially in excitable cells, in which they shape the action potentia

93 niques to follow the activation state of non-excitable cells, including lymphocytes.

94 tol trisphosphate (IP(3)) stimulation of non-excitable cells, including vascular endothelial cells, c

95 In excitable cells, ion channels are frequently challenged

96 In many excitable cells, KATP channels respond to intracellular

97 In non-excitable cells, KCNQ1 forms a complex with KCNE3, which

98 to modulate the plasma membrane potential of excitable cells, mitochondria have thus far eluded optog

99 Electrically excitable cells, such as neurons, exhibit tremendous div

100 d play a physiological role, particularly in excitable cells, which can generate large transients in

101 ding for proteins modulating the membrane of excitable cells, whose biological correlates are assesse

102 ls which leads to physiological signaling in excitable cells.

103 nels widely employed for photostimulation of excitable cells.

104 e primary mechanism for mCa(2+) extrusion in excitable cells.

105 ing signal transduction in neurons and other excitable cells.

106 Calcium Entry (SOCE) is well studied in non-excitable cells.

107 rrents and TRPM8-mediated calcium signals in excitable cells.

108 and frequency of action-potential firing in excitable cells.

109 l players in many physiological processes in excitable cells.

110 nderstanding of the role of Kv11 currents in excitable cells.

111 tic changes and the electrical properties of excitable cells.

112 nnels often overlaps in neurons and in other excitable cells.

113 eatly enhances their functional diversity in excitable cells.

114 of action potentials is commonly observed in excitable cells.

115 als in nerve, muscle, and other electrically excitable cells.

116 um (K(+)) channel desirable for silencing of excitable cells.

117 for optogenetic stimulation of electrically excitable cells.

118 ght control of resting membrane potential in excitable cells.

119 s a novel regulator of cell processes in non-excitable cells.

120 critical for proper electrical signaling in excitable cells.

121 rize the voltage dynamics of large groups of excitable cells.

122 tion and propagation of action potentials in excitable cells.

123 Nav) channels propagate action potentials in excitable cells.

124 annel activity to gene expression changes in excitable cells.

125 trigger or modify action potentials (APs) in excitable cells.

126 maintenance of resting membrane potential in excitable cells.

127 ials is important to understand electrically-excitable cells.

128 iming mechanisms across different systems of excitable cells.

129 rol the upstroke of the action potentials in excitable cells.

130 on and propagation of electrical impulses in excitable cells.

131 protein underlying the membrane potential in excitable cells.

132 lectrical signals to biological responses in excitable cells.

133 cal for chemical and electrical signaling in excitable cells.

134 els are crucial for electrical signalling in excitable cells.

135 second messengers in both excitable and non-excitable cells.

136 ed in modulating the electrical responses of excitable cells.

137 eceptors expressed in the plasma membrane of excitable cells.

138 responses that resemble action potentials in excitable cells.

139 als in nerve, muscle, and other electrically excitable cells.

140 ) initiate the action potential waveforms in excitable cells.

141 change that propagates along the membrane of excitable cells.

142 e quantification of calcium responses in non-excitable cells.

143 sodium channels (Navs) play crucial roles in excitable cells.

144 nt of intracellular Ca(2+) signaling in many excitable cells; however, the role of this mechanism in

145 se excitation and inhibition of electrically-excitable cellular activity.

146 ackground, and compatibility with blue-light-excitable channelrhodopsins.

147 h demyelinated axons were intrinsically more excitable, characterized by increased spontaneous suprat

148 cial neurons (ANs) is to use oscillatory and excitable chemical systems.

149 transitions from a quiescent state to a more excitable contractile state.

150 This mismatch suggests that apparently excitable cortical neurons (even >1 mm into peri-infarct

151 e results suggest that individuals with more excitable corticospinal pathways are faster to initiate

152 erse roles in neurons, including assembly of excitable domains such as the axon initial segment (AIS)

153 essly interfaced with genetically engineered excitable donor cells expressing inward rectifier potass

154 A sound excitable drug (SED) that is non-cytotoxic to cells is d

155 We surveyed 6 green and 16 red excitable dyes for their suitability in single-molecule

156 of useful dynamical behaviors, including the excitable dynamics also found in the time-resolved "spik

157 Simple models of excitable dynamics on graphs are an efficient framework

158 In models of excitable dynamics on graphs, excitations can travel in

159 n networks or the models used for describing excitable dynamics.

160 hippocampal and neocortical populations are excitable: each in a stable state from which internal fl

161 statistics can be predicted from an isolated excitable element with rescaled parameters according to

162 the stochastic dynamics of strongly-coupled excitable elements on a tree network.

163 l that sucrose cue exposure recruited a more excitable ensemble in the nucleus accumbens, but not orb

164 Despite being electrically excitable, enteroendocrine cells are generally thought t

165 shown that human dendrites are electrically excitable, exhibiting backpropagating action potentials

166 ations regardless whether the acceptor is an excitable fluorophore or a quencher.

167 First, lesions may create an excitable gap vulnerable to invasion by fibrillatory wav

168 nism was light-induced depolarisation of the excitable gap, which led to block of reentrant wavefront

169 tructures in situ, zG cells are electrically excitable, generating slow periodic voltage spikes and c

170 and validated a computational model of these excitable HEK293 cells (called "Ex293" cells) using exis

171 c sodium channels (BacNav) to create de novo excitable human tissues and augment impaired action pote

172 y to cortical activity, potentially enabling excitable immature neurons to contribute to sparse and o

173 sistent with a role in habits, FSIs are more excitable in habitual mice compared to goal-directed and

174 Notwithstanding endothelia being non-excitable in nature, the hypothesis of Ca(2+)-induced en

175 In basal conditions, MSNs are more excitable in parkinsonian than in sham mice, and excitab

176 )/H(+)-dependent drive to breathe, are hyper-excitable in slices from Scn1a(DeltaE26) mice.

177 physical model in which CMs are mechanically excitable inclusions embedded within the extracellular m

178 Excitable ion channels in stable small pores can serve a

179 the expression of genetically encoded photo-excitable ion channels.

180 robustly observed in excitable systems with excitable kinetics and with self-diffusion only.

181 d, chemically, electrically and mechanically excitable materials formulated in the 20th century was,

182 al excitation patterns in periodically-paced excitable media using mathematical models with different

183 ns for surface diffusion, pattern formation, excitable media, and bulk-surface coupling are provided

184 Biological excitable media, such as cardiac or neural cells and tis

185 stochastic coupled FitzHugh-Nagumo model for excitable media.

186 show theoretically that fundamentally in any excitable medium a region with a propagation velocity fa

187 dependent Ca(2+) signalling gives rise to an excitable medium across the functional syncytium of the

188 hreshold levels of one hormone can create an excitable medium across the liver lobule, which allows g

189 ortical tissue normally operates as a type I excitable medium but it is locally transformed into a ty

190 We present an excitable medium model to simulate the cycling behavior

191 rnal current, the model operated as a type I excitable medium that supported propagating waves of gam

192 hich propagate as active trigger waves in an excitable medium, and mitotic Cdk1 waves, which propagat

193 nd small amplitude-the hallmark of a type II excitable medium-yet they also propagate far beyond the

194 e stimulation site in the manner of a type I excitable medium.

195 neurons transformed the model into a type II excitable medium.

196 al and widely used two-component model of an excitable medium.

197 from the RPE, they are thought to regenerate excitable melanopsin exclusively through RPE-independent

198 that are ubiquitous in all domains of life, excitable membranes are found almost exclusively in anim

199 iming and waveform of APs generated from two excitable membranes present in each electrocyte.

200 Here we experimentally assembled excitable membranes using the dynamic clamp and voltage-

201 he potential to measure voltage optically in excitable membranes with a combination of high spatial a

202 ost neuronal tissue, exhibiting electrically excitable membranes, synaptic currents, dopamine release

203 on or direct channel block made neurons more excitable, minutes to hours of sustained M-current depre

204 Here we report three new red-excitable monomeric FPs obtained by structure-guided mut

205 find that, despite weighted excitation, more excitable motoneurons are preferentially activated by a

206 Individuals with more excitable motor pathways had faster reaction times and,

207 of inhibition, which is most obvious in more excitable motor pools.

208 tor cortex counteracts an intrinsically more excitable motor system.

209 within M1, possibly to compensate for a more excitable motor system.SIGNIFICANCE STATEMENT This study

210 e resonance of these phasic-firing (type III excitable) MSO neurons and of the model is of particular

211 The use of NIR excitable NaYF(4):Yb(3+),Tm(3+) UCNPs enables background

212 When expressed in excitable nerve and muscle cells, ChRs can be used to co

213 The central module is an excitable network that accounts for random migration.

214 hese properties require coupled adaptive and excitable networks.

215 membrane organization occur in fibroblasts, excitable neuroblastoma cells, and Drosophila neurons in

216 ponses from highly excitable neurons to less excitable neurons as the cost of neural activity increas

217 l redistribute sensory responses from highly excitable neurons to less excitable neurons as the cost

218 re trained on a new task during this period, excitable neurons were reactivated and memory formation

219 Temporal engraftment of electrical excitable nodal-like cardiomyocytes may thus explain the

220 nated distal dendritic tree-like arbors with excitable nodes of Ranvier at peripheral and branching n

221 Finally, these pulses are excitable only beyond a threshold for protonation, deter

222 Using independently excitable opsins to interrogate multiple inputs onto a s

223 nimal spectral cross talk with visible light excitable optogenetic tools and fluorescent probes, and

224 Electrophysiological studies of excitable organs usually focus on action potential (AP)-

225 strategy to achieve ultrabright, green laser-excitable Pdots with narrow-band NIR emission by introdu

226 TMS inputs arriving at the excitable phase of beta oscillations in the motor cortex

227 st, 'Atypical' inhibitory neurons with their excitable phenotype but weak excitatory input may be mor

228 ificant hydrophobicity of most visible-light excitable photocaging groups.

229 highly reactive radicals, and visible light excitable photocatalysts can provide the required oxidat

230 luminescent Orban transformations, and photo-excitable photochromic and fluorescent species.

231 The recent emergence of visible-light excitable photoprotecting groups has the potential to fu

232 hyrin (URO) and their loading with red light excitable phthalocyanines (PC) that was cationized by ch

233 Neurons are electrically excitable, postmitotic cells that perform sensory, relay

234 In addition, excitable pre-OLs receive glutamatergic inputs from neig

235 ively because it neglects the details of the excitable propagation, we find that it accounts for the

236 ross their plasma membrane to maintain their excitable properties under varying environmental conditi

237 y recruited during locomotion have identical excitable properties.

238 A computational model shows that the coupled excitable Ras/F-actin system forms the driving heart for

239 formation is a shift to a lower threshold of excitable Ras/PI3K/ERK network, caused by various combin

240 ationalize our observations based on a noisy excitable reaction-diffusion model in combination with a

241 e that this 'proneural wave' is driven by an excitable reaction-diffusion system involving epidermal

242 a newly developed FRET donor, monomeric cyan-excitable red fluorescent protein (mCyRFP1), which has a

243 shortest action potential duration and less-excitable region, consistent with drift direction under

244 We show that soft spots, or excitable regions in the materials, correspond to rollin

245 ho activation in adherent cells and proposed excitable Rho signaling networks underlying cell contrac

246 ells express GPR68 gene and protein, whereas excitable secretory cells express ASIC genes and protein

247 Bright long-wavelength-excitable semiconducting polymer dots (LWE-Pdots) are hi

248 Studies show that an excitable signal transduction network acts as a pacemake

249 tematically more drive to progressively less excitable spinal motoneurons.

250 These synapses are located within large excitable spines that can generate local action potentia

251 al and the mechanism of transition to a more excitable state have not been fully clarified.

252 s to depolarize more readily to a variety of excitable stimuli.

253 e that sugar recruits a distributed dopamine-excitable striatal circuitry that acts to prioritize ene

254 e typically involved neurons/models (type II excitable, such as the standard Hodgkin-Huxley model) th

255 This coupled excitable system leads to short-lived patches of activat

256 Cardiac tissue is an excitable system that can support complex spatiotemporal

257 es that the segmentation clock behaves as an excitable system, introducing a broader paradigm to stud

258 Fractional-order dynamics of excitable systems can be physically described as a memor

259 that activation of Ras and F-actin forms two excitable systems that are coupled through mutual positi

260 t quasi-solitons can be robustly observed in excitable systems with excitable kinetics and with self-

261 Crawling cells show many features of excitable systems, such as spontaneous symmetry breaking

262 rmal method to link genotype to phenotype in excitable systems.

263 l of pattern formation in complex biological excitable systems.

264 namics may redesign the firing properties of excitable systems.

265 ns, have been observed also in dissipative, "excitable" systems, either at finely tuned parameters (n

266 MHbVL neurons were more excitable than MHbVC neurons, and they also responded mo

267 OFC, these activated GFP+ neurons were more excitable than surrounding GFP- neurons.

268 ii) neurons from SAL-Yoked Tg rats were more excitable than those from SAL-Yoked non-Tg rats, and in

269 (from remodeling) produced re-entry in more excitable tissue allowing collision of wavefront and bac

270 and abnormal conduction in multidimensional excitable tissue, and the methodology of modeling variat

271 bility regions migrated spiral waves to less excitable tissue, where they detached to collide with no

272 ion channels mediate electrical dynamics in excitable tissues and are an important class of drug tar

273 d for non-invasive investigations of diverse excitable tissues and may ultimately be applied for trea

274 fundamental roles in both excitable and non-excitable tissues and therefore constitute attractive dr

275 eneral mechanism for how nervous systems and excitable tissues can exploit degenerate relationships a

276 onstrated the ability to create biosynthetic excitable tissues from genetically engineered and immort

277 To understand how excitable tissues give rise to arrhythmias, it is crucia

278 fever can negatively impact the function of excitable tissues, such as the heart, producing cardiac

279 dium channels (Navs) play essential roles in excitable tissues, with their activation and opening res

280 propagation of the action potential through excitable tissues.

281 d to changes in membrane potential (V(M)) in excitable tissues.

282 e the rapid upstroke of action potentials in excitable tissues.

283 acellular calcium ([Ca(2+)]i) homeostasis in excitable tissues.

284 r supports a nonconducting role for Kv2.1 in excitable tissues.

285 lling electrical activity in heart and other excitable tissues.

286 ient electrical transduction in electrically excitable tissues.

287 n response properties changed from uniformly excitable to differentially plastic.

288 in nesting hippocampal ripples within their excitable troughs, stimulation in-phase with the slow os

289 ut opposed it in striosomes, which were more excitable under basal conditions.

290 older neurons appeared to be uniformly less excitable under baseline conditions yet displayed a prev

291 re active or might become intrinsically more excitable under the pathological conditions that produce

292 Using a basic model of discrete excitable units that follow a susceptible - excited - re

293 al FitzHugh-Nagumo-type model to investigate excitable wave propagation in a two-dimensional heteroge

294 s propagate signals in a directed manner via excitable waves.

295 expressing the Scn1a A1783V variant are less excitable, whereas glutamatergic chemosensitive RTN neur

296 occur when the CRU network is monostable and excitable, while long-lasting sparks occur when the netw

297 ensors have several advantages such as being excitable with red light, emitting in the near-infrared

298 KEY POINTS: Optic nerve axons get less excitable with warming.

299 and synthesis of a new type of RE-free, blue-excitable yellow phosphor, obtained by combining a stron

300 ternal quantum yield among all RE-free, blue-excitable yellow phosphors reported to date, with a valu