ライフサイエンスコーパス: exert @1 effect

1 nd potential traumatic brain injury may also exert an effect.

2 while an enzymatically inactive form of TAK1 exerts no effect.

3 fy the molecular mechanism of how glypican 4 exerts its effect.

4 nical pathways whereby several of our probes exert their effect.

5 he view of how this important class of drugs exerts its effects.

6 synaptic transmission, it is unknown how it exerts this effect.

7 riants alter transcription factor binding to exert their effects.

8 dentifying pathways through which treatments exert their effects.

9 TMDs) and how TMD-targeting allosteric drugs exert their effects.

10 ocess and potential mechanism(s) by which it exerts these effects.

11 ng in a reduced immune response, whereas STE exerted minimal effects.

12 to maintain contact with the bloodstream to exert protective effects.

13 attrition, amount of food and begging effort exerted additive effects.

14 ld type and mutant hearts, whereas CaM (1-4) exerted opposite effects.

15 anoma A2058 cells, whereas GALC upregulation exerted opposite effects.

16 his study, we investigated whether they also exerted proviral effects.

17 wever, it remained unclear whether they also exerted proviral effects.

18 (Z-DeltaAbu), and bulky (DeltaVal) DeltaAAs exerting similar effects.

19 s a competitor in the regulatory complex and exerting opposite effects.

20 phorylation at different positions sometimes exerting opposite effects.

21 ecular mechanism whereby activation of OXTRs exerts anxiolytic effects.

22 to activate the endogenous APN receptors to exert osteoanabolic effects.

23 even relatively small volumes of saline may exert physiological effects.

24 ombospodin-1 played an important role in ACM-exerted synaptogenic effects.

25 s delivery of combinatorial cell populations exerting synergistic effects.

26 toward less inflammatory phenotypes and may exert neuroprotective effects.

27 r desensitization) implies that agonists may exert neuroprotective effects.

28 osin-related kinase A (TrkA), and to thereby exert neuroprotective effects.

29 Beyond lipid-lowering, statins exert cardioprotective effects.

30 y, providing a novel mechanism whereby IGF-1 exerts antiatherogenic effects.

31 ibody-mediated neutralization of pHERV-W ENV exerts neuroprotective effects.

32 ongs to the active form of GSK3beta known to exert neuroinflammatory effects.

33 echanisms that allow IL-2-STAT5 signaling to exert divergent effects across CD4(+) T cell subsets and

34 strogen receptor modulation, isoflavones may exert beneficial effects against estrogen-deficient bone

35 helial cells that are constructed to rapidly exert biocidal effects against invader pathobiotic bacte

36 We conclude that neuronal swelling may exert protective effects against damaging excitability i

37 Guanabenz and Sephin1) have been proposed to exert protective effects against misfolding by interferi

38 Ti particles exerted cytotoxic effects against fibroblasts, whereas s

39 e BSG protein hydrolysates (fraction <10kDa) exerted protective effect against free-radical induced c

40 ly, these results strongly indicate that Myr exerts cardioprotective effects against DCM through the

41 acts as a powerful CR proxy in dementia and exerts neuroprotective effects against neurodegeneration

42 kephalins, endogenous opioid peptides, which exert cardiodepressive effects and improve renal functio

43 mechanisms by which a noncoding mutation may exert its effect and discuss future challenges and oppor

44 d mechanism through which dominant mutations exert their effect and cause disease.

45 s to determine at what regulatory level they exert their effects and to what extent they can compleme

46 s may represent important targets for GAs to exert toxic effects and that astrocyte morphological int

47 However, how HBL exerts its effects and whether it requires any host fact

48 ctivity is one of the mechanisms by which it exerts mucoprotective effects and that counter-regulator

49 HuMC function, the mechanisms by which IL-6 exerts its effects, and the relationship of these findin

50 d molecular mechanisms through which CBD may exert these effects are entirely unknown.

51 expression in the developing neuroepithelium exerted identical effects as those of PD-MARCKS.

52 hereas the neurosteroid pregnenolone sulfate exerted similar effects as progesterone, likely binding

53 lls may accumulate at high concentrations to exert promiscuous effects at the beta-cell GLP-1R, as ma

54 hosphorylated alpha-synuclein is believed to exert toxic effects at the synapse in dementia with Lewy

55 Gal-3 also exerts proinflammatory effects, at least in extracardiac

56 Selenium (Se) exerts many effects beneficial to health.

57 ity-generated forces, but flagellum motility exerts distinct effects between different life cycle for

58 these findings suggest that pridopidine may exert neuroprotective effects beyond its role in allevia

59 ge, aminoglycosides are taken into cells and exert bacteriostatic effects by inhibiting translation.

60 ecreted from the iPSC-derived cardiomyocytes exert protective effects by transferring the endogenous

61 ible factors (HIF-1alpha and HIF-2alpha)-can exert renoprotective effects by promoting autophagic flu

62 , we found that doxycycline and rifamycin SV exert their effect by binding to oligomeric species both

63 ntivirals, notably nucleoside analogs (NAs), exert their effect by incorporation into viral genomes a

64 Traditional inotropic agents exert their effect by modulating calcium signaling in th

65 ction is still unknown, SSRIs are thought to exert therapeutic effects by elevating extracellular ser

66 Myc oncoproteins exert tumorigenic effects by regulating expression of ta

67 More important, NC1-peptide exerted its effects by downregulating the expression of

68 Bilirubin exerted its effects by recruiting and dissociating speci

69 miR-124-3p exerted these effects by targeting PDE4B, thus inhibitin

70 mune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and I

71 icagrelor, beyond its antiplatelet efficacy, exerts cardioprotective effects by reducing necrotic inj

72 We show that 16:4(n-3) exerts its effect by activating splenic F4/80(+)/CD11b(l

73 osine kinases (SPHK1 and SPHK2), that mainly exerts its effects by binding to the following 5 GPCRs:

74 effects, which can last several months, and exerts its effects by specifically cleaving and inactiva

75 These data suggest that histamine exerts protective effects by modulating cardiac fibrosis

76 Mechanistically, we demonstrate that APP-103 exerts protective effects by specifically targeting the

77 that in the early stage of OA, knee loading exerts protective effects by suppressing osteoclastogene

78 ) signaling, a natriuretic peptide receptor, exerts renoprotective effects by stimulating natriuresis

79 It has been suggested that Lmo2 exerts these effects by functioning as component of a mu

80 However, 2-DG exerts these effects by inducing unfolded protein respon

81 inducer of keratinocyte differentiation; it exerts this effect by directly repressing SOX6.

82 Mechanistically, VEC exerts this effect by inhibiting polycomb protein activi

83 The phage exerts this effect by upregulating a host-encoded signal

84 icular aspects of this signaling pathway may exert these effects directly on the urothelium.

85 Further we demonstrated that DDIT4 exert these effects down-stream to HIF1alpha.

86 y-bound calmodulin, whereas higher [Ca(2+) ] exerts inhibitory effect during depolarization.

87 However, the mechanisms by which exercise exerts its effects, especially in humans, are not fully

88 urveys the proposed mechanisms by which they exert their effects, from the nucleus to the cellular me

89 rated understanding of how the lipid bilayer exerts its effect has remained elusive.

90 However, the mechanism by which it exerts its effects has been unclear.

91 that allows iNKT cells to escape anergy and exert beneficial effects in biphasic sepsis.

92 We have previously shown that TRPC6 agonists exert beneficial effects in models of AD and may serve a

93 Amyloid aggregates have been demonstrated to exert cytotoxic effects in several diseases.

94 est that the gastrointestinal microbiome may exert immunomodulatory effects in allo-HCT patients at l

95 Although BMI1 is known to exert its effect in the nucleus via repression of 2 pote

96 presents a new mode through which Nogo-A may exert its effects in the central nervous system.

97 y and determined that two of these compounds exert neuroprotective effects in the nanomolar concentra

98 malignant, viral, and bacterial disease, and exert pathological effects in autoimmune disorders.

99 l studies show that PDE5 inhibitors (PDE5is) exert protective effects in DN improving perivascular in

100 is not known whether these genetic variants exert their effects in younger individuals.

101 inoid epoxides 17,18-EEQ-EA and 19,20-EDP-EA exerted antiangiogenic effects in human microvascular en

102 Exogenous expression of Elk-1 exerted beneficial effects in a primary striatal cell cu

103 Notably, two isoforms of OPN exerted distinct effects in shifting this balance throug

104 d clathrin-mediated endocytosis of AQP2, but exerted its effect in a cAMP, PKA and S256 phosphorylati

105 While reduction of IL6 expression exerted limited effects in vitro, its attenuation signif

106 Transglutaminase addition exerted significant effect in the technological properti

107 e regulators of the renin-angiotensin system exerting cardioprotective effects in models of heart fai

108 observations of Activin-mediated mechanisms exerting deleterious effects in models of obesity and di

109 uroactive, modulating neuroplasticity and/or exerting neurotoxic effects in part through their effect

110 ic compartment-specific IFN-gammaR signaling exerts additive effects in orchestrating intracerebral i

111 Oxytocin (OXT) is a nonapeptide that exerts anxiolytic effects in the brain.

112 l-Carnitine (LC) exerts beneficial effects in arterial hypertension due,

113 apy, including immune checkpoint inhibitors, exerts beneficial effects in cancer patients.

114 Thus, RS exerts beneficial effects in lupus-prone hosts through s

115 of CB2R, overexpressed in microglial cells, exerts beneficial effects in neurodegenerative disorders

116 To interrogate whether insulin exerts endocrine effects in regulating proteins in the i

117 of the mechanisms by which GLP-1R activation exerts its effects in preventing or arresting experiment

118 t cromolyn sodium, an FDA approved compound, exerts neuroprotective effects in mouse models of Alzhei

119 Since glucagon-like peptide 1 (GLP-1) exerts neuroprotective effects in the central nervous sy

120 B-cell CLL/lymphoma 6 (BCL6) exerts oncogenic effects in several human hematopoietic

121 IL-27 exerts protective effects in autoimmune diseases like ex

122 In conclusion, the majority of envirome exerts their effects in a dynamic network via transitive

123 The peptide hormone ghrelin exerts pleiotropic effects including the stimulation of

124 cognate G protein-coupled receptor (OTR) and exerts diverse effects, including stimulation (G(s)) or

125 ms, suggesting that psychological treatments exert biological effects independent of symptom reductio

126 tioxidant inhibition of break formation also exert partial effects, independently of rupture.

127 nhibiting renal fibrosis and hypertrophy and exerts protective effects involving cGMP/cGK axis by rep

128 owever the developmental stage at which CDX2 exerts its effect is unknown.

129 secretion, but the mechanism by which GLP-1 exerts this effect is unclear.

130 antation of eMSCs into the lateral ventricle exerted antidepressant effects likely acting via neuroge

131 The scaffolded nontransdifferentiated hMSCs exerted multimodal effects of neurotrophism, angiogenesi

132 disrupting chemical bisphenol A (BPA) while exerting estrogenic effects of comparable potency.

133 nd the subsequent deposition to land surface exert adverse effects on biogeochemical nitrogen (N) cyc

134 cytoskeletal regulator tropomyosin 4 (TPM4) exert an effect on the count and volume of platelets.

135 (PD-L1), but it remains unknown whether they exert any effects on B cells, the other component of the

136 es that consist of 2-20 amino acids that can exert beneficial effects on human health in addition to

137 rated fatty acids (PUFA) such as EPA and DHA exert beneficial effects on intestinal integrity in anim

138 ntation with butyrate-producing bacteria may exert beneficial effects on T2D.

139 ed oriented external electric fields (OEEFs) exert catalytic effects on the kinetics and improve the

140 ht the potential for comorbidity clusters to exert combined effects on asthma outcomes.

141 teraction with human serum albumin (HSA) can exert considerable effect on the absorption, distributio

142 Melanoidins did not exert cytotoxic effects on Caco-2 and HUVEC cells (viabi

143 tion during aging and suggest that TREM2 may exert detrimental effects on neuronal function.

144 ifferent structural forms of alpha-synuclein exert different effects on Abeta aggregation.

145 Hence, the same mutation can exert different effects on ARs in class I or II promoter

146 ypothesized that prednisolone and infliximab exert different effects on levels of STC2, PAPP-A, and I

147 In addition, these domains exert differential effects on spatial and contextual lea

148 s the programmed death ligand (PD-L1), might exert differential effects on T-cell function, depending

149 ifestyle and physiological variables(2) that exert differential effects on the microbiota.

150 ule cytoskeleton and the JIP3 protein UNC-16 exert distinct effects on localization of axonal and som

151 more slowly conducting CST axons, as well as exert disynaptic effects on motoneurons via interposed i

152 ain and Ras/Rap1-specific endopeptidase each exert greater effects on virulence than other MARTX doma

153 r cells in a contact-dependent manner or may exert indirect effects on tumor cells via secretion of c

154 is necessary for the ability of cytokinin to exert inhibitory effects on lateral root production.

155 Additionally, C. albicans can also exert inhibitory effects on platelet aggregation.

156 activins, and growth differentiation factors exert inhibitory effects on red cell formation by activa

157 ylation site, cg05126514 within the BSN gene exert its effect on CAD through central nervous system-l

158 es were absolutely required for TGF-beta1 to exert its effect on SMAD-binding sites.

159 trogen sources and quorum sensing molecules, exert limited effects on this PAMP.

160 exist in current understanding of how tumors exert local effects on resting-state functional MRI read

161 many countries and has been demonstrated to exert negative effects on poultry welfare and production

162 e transitions and how state-encoding neurons exert neuromodulatory effects on sensory perception and

163 contribute to disease propagation as it may exert noxious effects on neighboring cells.

164 Rac and Rho GTPases exert opposing effects on cell morphology and are stimul

165 s that modulate pathways important in CR may exert opposing effects on different cell types.

166 t ways in which highly similar molecules may exert opposing effects on neurons.

167 lence, illustrating that a single factor may exert opposing effects on pathogenesis in distinct host

168 and interneurons in the dorsal striatum and exert opposing effects on sensory-guided behavior.

169 Hence, TSPY and TSPX exert opposing effects on the transactivation functions

170 Although C1QBP has been reported to exert pleiotropic effects on many cellular processes, we

171 Aberrantly expressed lncRNAs in HCC exert pleiotropic effects on miRNAs, mRNAs, and proteins

172 n in reptiles and indicating that these loci exert pleiotropic effects on other aspects of physiology

173 g time genes Ppd-H1, Sdw1, Vrn-H1 and Vrn-H3 exert pleiotropic effects on plant development and grain

174 ilizes the rigidity of the outer membrane to exert pleiotropic effects on the functionality of gram-n

175 ile pharmacological doses of HDAC inhibitors exert positive effects on Bdnf gene transcription, the i

176 lic steatohepatitis (NASH) patients, as they exert positive effects on multiple aspects of the diseas

177 une cells in the tumor microenvironment that exert potent effects on cancer metastasis.

178 Seminal fluid proteins (SFPs) exert potent effects on male and female fitness.

179 MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate re

180 (NASs) are synthesized within the brain and exert profound effects on behavior.

181 ays, an event frequently observed in cancer, exert profound effects on genome stability via MRE11 wit

182 The recognition that intestinal microbiota exert profound effects on human health has led to major

183 Fluorine, well-known to exert profound effects on the physical and chemical prop

184 th and that the two RNA-binding proteins can exert regulatory effects on common targets.

185 n findings indicate that ankle-foot orthoses exert significant effects on coronal and sagittal plane

186 is a technique for preserving food that may exert some effects on mycotoxins.

187 These factors modify DNA and histones and exert specific effects on cell biology, systemic physiol

188 l regulatory role (SF3A3, ILF3, and N4BP2L2) exert their effect on CAD through height.

189 previously intractable human diseases but to exert their effects on cellular RNA processing they must

190 ve our understanding of how genetic variants exert their effects on complex traits and disease.

191 re no longer necessary but might continue to exert their effects on recipient cells.

192 General anesthetics exert their effects on the central nervous system by act

193 Cannabinoids exert therapeutic effects on several diseases such as ch

194 Hcy) during chronic kidney failure (CKD) can exert toxic effects on the glomeruli and tubulo-intersti

195 ar though if exposure to these chemicals can exert toxic effects on the host and gut microbiome.

196 that Cx26 mutants that promote cell death or exert transdominant effects on other connexins in kerati

197 Psychedelics exert unique effects on human consciousness.

198 We also show that HER receptor ligands exert unique effects on signaling by modulating this beh

199 ogical parameters and OCA + ELA combinations exerted additive effects on metabolic and histological e

200 INT-767 exerted coordinated effects on multiple pathways, includ

201 Each lipid in concern exerted different effects on the digestibility of starch

202 BL proteins exerted differential effects on TEER, whereas astrocytes

203 egnant rats treated with insulin alone often exerted distinct effects on placental gene expression co

204 lities and fetal loss, whereas insulin often exerted distinct effects on placental gene expression co

205 In vitro, Nell2 exerted inhibitory effects on contralateral, but not ips

206 contrast, inhibition of IL-6 trans-signaling exerted minor effects on the immune response and did not

207 Street canopy exerted opposing effects on loading, where elevated nutr

208 Recombinant MIF exerted opposing effects on tubular cells in vitro and i

209 Correspondingly, arsenic exposure exerted opposite effects on the serum cholesterol levels

210 ing reporter assays where all tested regions exerted regulatory effects on transcription in epithelia

211 Further, the bleomycin conjugate exerted selective effects on the miRNome and proteome in

212 The compound exerted selective effects on the transcriptome and selec

213 High-dose POMA exerted significant effects on clinical symptoms, but no

214 that HvgA and capsule, but not the beta-h/c, exerted significant effects on colonization of the murin

215 omega-3 PUFAs exerted similar effects on the differentiation of CD4+ T

216 effects by promoting autophagic flux and by exerting direct effects on sodium transport and inflamma

217 cking Ship1/2 abrogated EMC cell survival by exerting dual effects on the BCR signaling cascade.

218 Syt1-dependent mechanisms to produce PTP by exerting multiplicative effects on release rates.

219 acetylation of histone H4, but not H3, while exerting no effect on the expression of BRD proteins.

220 Strikingly, the combination of RSV with NAM, exerts additive effects on PARP1 activation.

221 t one of the most promising ligands not only exerts an effect on insulin secretion in rat pancreatic

222 o function like a canonical Rca; instead, it exerts an effect on the response to CO(2) availability a

223 ger-associated molecular pattern recognition exerts antitumor effects on peritoneal metastases by ind

224 Environmental enrichment (EE) exerts beneficial effects on brain plasticity, cognition

225 Recent studies demonstrate that Honokiol exerts beneficial effects on cardiac hypertrophy and dox

226 We hypothesized that TNF exerts beneficial effects on intestinal epithelial cell

227 We hypothesized that TMAO exerts beneficial effects on the circulatory system and

228 Our findings demonstrate that Sox9 exerts concerted effects on transcription, BP proliferat

229 Nutrition exerts considerable effects on health, and dietary inter

230 further suggests that the central NPY system exerts differential effects on the sequential phases of

231 We tested whether repeated stress exerts distinct effects on BLA in vivo neuronal activity

232 dent models suggests that PACAP manipulation exerts downstream effects on peripheral hormones and beh

233 tion sites within the ABO gene and that SELE exerts its effect on CAD through immune, glycemic, and l

234 In contrast, BRCA2 exerts its effect on HR in human cells together with HsR

235 GD1a exerts its effect on OPCs by inducing their proliferatio

236 WASP exerts its effects on actin dynamics through a multisubu

237 pproaches, we provide evidence that miR-iab4 exerts its effects on adult self-righting behavior in pa

238 However, it remains unclear whether MSA exerts its effects on cancer prevention by influencing a

239 re detailed knowledge about how hyperthermia exerts its effects on chemotherapy may illuminate ways t

240 in our experimental models suggest that iron exerts its effects on leptin by decreasing O-glycosylati

241 heral to the central nervous system and that exerts its effects on neurons by signalling through tyro

242 al a non-canonical mechanism by which GPR158 exerts its effects on stress-induced depression by the c

243 ffect: -2.70; p = 0.03), indicating that DUP exerts its effects on treatment response through affecti

244 Estrogen exerts many effects on the vascular endothelium.

245 However, whether BDNF exerts metabolic effects on peripheral organs is current

246 mulation; without serine 269, Src inhibition exerts no effect on AQP2 trafficking.

247 Thus, cAMP-downregulation by CIRL exerts opposing effects on low-threshold mechanosensors

248 Crystal structures reveal how each disulfide exerts opposing effects on structure and function.

249 irst example that a single auxiliary subunit exerts opposite effects on evolutionarily related channe

250 Nitric oxide (NO) exerts pleiotropic effects on plant development; however

251 nsulin resistance, whereas exercise training exerts positive effects on substrate handling and improv

252 cal role in many physiological processes and exerts profound effects on behavior by regulating neuron

253 und widely in phytophagous insects and often exerts profound effects on the phenotype and fitness of

254 e detailed investigation revealed that SIRT6 exerts repressive effects on multiple promoters of KSHV.

255 and epithelium; 3) a muscle genetic program exerts significant effects on ENS development; and 4) se

256 yrosine kinase inhibitory activity, DV2-103, exerts similar effects on APP metabolism.

257 Rescue experiments suggest that Spz3 can exert these effects only over very short distances.

258 ase risk may result from regulatory variants exerting their effects only in the presence of immune st

259 rugs in clinical use and under investigation exert pharmacological effects or improve efficacy of coa

260 DAQ exerts its effect primarily on RGCs, whereas DAA induces

261 tive triphosphate metabolite, Ara-CTP, which exerts antileukemic effects, primarily by inhibiting DNA

262 neuronal populations and neuro-mediators can exert opposing effects, promoting or inhibiting tissue i

263 Adipose-derived stem cells (ADSCs) exert paracrine effects protecting chondrocytes from deg

264 nding of the mechanisms by which these drugs exert their effects remained elusive.

265 Moreover, transplantation does not exert therapeutic effects solely by restoring wild-type

266 Variants in the TOM1L2/SREBF1 locus exert opposing effects TB-LM and TBLH-BMD, and have a st

267 ." It has been postulated that smoking might exert protective effects that could reduce infarct size,

268 tions with prebiotics and probiotics seem to exert immunological effects, their clinical implications

269 ch as 5-fluorouracil (5-FU) and oxaliplatin, exert such effects, their combination as employed in the

270 nstrates that a Wogonin-rich fraction of SBE exert chondroprotective effects through the suppression

271 Classically, Epac1 is thought to exert its effects through binding of cAMP leading to a c

272 In a mathematical model, perturbations often exert their effect through parameters, so sizes and shap

273 We additionally demonstrated that protons exert their effect through sensitization of PLCdelta1 to

274 General anesthetics (GAs) exert their effects through endogenous sleep-wake contro

275 a majority of disease-associated variants to exert their effects through pancreatic islet dysfunction

276 Glucocorticoids exert their effects through the glucocorticoid receptor

277 , have roles in metabolic regulation and may exert their effects through this mechanism.

278 cholerae, and it was previously presumed to exert this effect through regulation of quorum sensing.

279 d discrepancy, PF analysis revealed that FED exerted its effects through multiple JAK2-independent me

280 Aspirin exerts antiplatelet effects through irreversible inhibit

281 The free radical nitric oxide (NO(*)) exerts biological effects through the direct and reversi

282 that the amyloid aggregation process per se exerts cytotoxic effects through the interaction of amyl

283 hing is known about the extent to which CodY exerts its effect through small regulatory RNAs (sRNAs).

284 with type 2 diabetes; however, whether they exert joint effects to exacerbate type 2 diabetes risk i

285 Studies suggest that NGB exerts protective effects to neuronal cells and is impli

286 Oriented electrostatic fields can exert catalytic effects upon both the kinetics and the t

287 duction in vivo provides a source of NO that exerts beneficial effects upon the cardiovascular system

288 Therapeutic anti-Env Abs can also exert antiviral effects via Fc-mediated effector mechani

289 iotics and other environmental chemicals may exert neurobehavioral effects via disruption of host-ass

290 Here we show that RAF inhibitors exert their effects via two distinct allosteric mechanis

291 ment of relapsing multiple sclerosis and may exert therapeutic effects via activation of the nuclear

292 t of LIN28B-an oncofetal RNA-binding protein exerting diverse effects via negative regulation of let-

293 The operon exerts its effect via an encoded transcription factor ca

294 on in these cells, confirming that quercetin exerts its effect via SIRT-1.

295 owever, to date, no single therapeutic agent exerts its effects via perturbing heterotrimeric G prote

296 Experimental studies show that statins exert additive effects with agents, such as cisplatin, t

297 modulate microglia-mediated inflammation and exert neuroprotective effects, with potential for allevi

298 These metabolites exert their effects within the host as signalling molecu

299 h focal epilepsy, and epileptic activity can exert widespread effects within the brain.

300 morrhagic stroke outcome, suggesting that it exerts thrombolytic effects without significantly impair