ライフサイエンスコーパス: exert its

1 mine's modulation of an affective network to exert its action.

2 re the expression of a global mechanism that exerts its action across the entire visual field.

3 We also show that ASIC1a exerts its action in hippocampal LTP through multiple me

4 usly unknown layer of antiviral defense that exerts its action on epithelial surfaces before the clas

5 F2357 is a potential anti-fibrotic drug that exerts its action via activation of Id3, a downstream ta

6 Vitamin D exerts its actions through the vitamin D receptor (VDR),

7 the absence of PKCzeta, suggesting that ZIP exerts its actions via additional cellular targets.

8 In PI/galactosylceramide mixtures, DAG may exert its activation role through the generation of smal

9 in vitro and in vivo Mechanistically, PPARD exerted its activity in a DNA binding-dependent and liga

10 The antimicrobial peptide nisin exerts its activity by a unique dual mechanism.

11 CECR2 depletion, suggesting that NVS-CECR2-1 exerts its activity by targeting CECR2.

12 We also demonstrate that PACAP in the CeA exerts its anorectic effects via local melanocortin and

13 One mechanism used by Fh12 to exert its anti-inflammatory effect is binding to the CD1

14 rtue of its PT-stimulated NTPase activity to exert its anti-phage activity, and (2) SspE inhibits pha

15 Mechanistically, PO exerted its anti-inflammatory function through AMP-activ

16 B13 exerted its anti-invasive and antitumor effects against

17 We now show that NF-kappaB exerts its anti-inflammatory activity by inducing delaye

18 in breast cancer and to elucidate how RK-33 exerts its anti-neoplastic effects.

19 ts suggest a novel mechanism(s) by which HNK exerts its anti-tumor activity through the inhibition of

20 affect the active compound's availability to exert its antibacterial action in a specific food.

21 alysis(TM) (IPA) suggested that curcumin may exert its anticancer effects over multiple critical biol

22 e findings suggest that cannabidiol could be exerting its anticonvulsant effects, at least in part, t

23 Ketamine has been proposed to exert its antidepressant effects through its metabolite

24 While (2R,6R)-HNK is thought to exert its antidepressant-like effects by potentiating al

25 understanding of the mechanism by which TMS exerts its antidepressant effect is minimal.

26 suggest a neural mechanism by which ketamine exerts its antidepressant efficacy, via rapid blunting o

27 ported into the cytoplasm of these fungi and exerts its antifungal activity on intracellular targets.

28 -19) is a recently identified fungicide that exerts its antifungal effect on susceptible Fusarium spe

29 IL-28A exerts its antiinflammatory effect by restricting recrui

30 s taken up specifically by target cells, and exerts its antileukemia effects largely by restoring the

31 Our data support a model in which KAE609 exerts its antimalarial activity by directly interfering

32 Lacticin 3147 may exert its antimicrobial effect by several mechanisms.

33 chemokines and antimicrobial peptides, CK11 exerted its antimicrobial activity, rapidly inducing mem

34 ogether, these data suggest that alpha-PanAm exerts its antimicrobial activity by direct competition

35 PL-deficient mice revealed that this protein exerts its antineoplastic function through the regulatio

36 Mfn2 exerts its antiproliferative effect by acting as an effe

37 Nociceptin exerts its antistress effect by counteracting the functi

38 tion in the presence of cellular thiols, LNM exerts its antitumor activity by an episulfonium ion-med

39 Together, these results demonstrate that JA exerts its antitumor activity by targeting SF3B1 and SF3

40 However, how PG545 exerts its antitumor effect remains incompletely defined

41 n actually exploits radical SAM chemistry to exert its antiviral activity.

42 r, the cell(s) upon which IFN-lambda acts to exert its antiviral effects is unclear.

43 We sought to determine how RNase L exerts its antiviral activity during influenza virus inf

44 Furthermore, it is not clear whether MxA exerts its antiviral activity in a monomeric and/or mult

45 Furthermore, we determined that EFTUD2 exerts its antiviral activity mainly through governing i

46 revious studies showed that ZAPL (PARP-13.1) exerts its antiviral activity via its N-terminal zinc fi

47 These results suggest that Ifit2 exerts its antiviral effect mainly at the level of viral

48 In searching for mechanisms how TRIM14 exerts its antiviral function we found that TRIM14 inter

49 hether OXT activates eEF2 also in neurons to exert its anxiolytic properties in the PVN, we performed

50 These findings demonstrate that BHB exerts its anxiolytic effects, possibly by inhibiting sy

51 Here we show that TriA1 exerts its bactericidal effect by binding to the bacteri

52 Nicotine exerts its behavioral and additive actions through a fam

53 Cocaine exerts its behavioral stimulant effects by facilitating

54 cal SCI and provides evidence that DHA could exert its beneficial effects in SCI via enhancement of n

55 This provides direct evidence that DHA could exert its beneficial effects in spinal cord injury via n

56 it remained unclear whether ruxolitinib was exerting its beneficial effects in HLH by inhibiting IFN

57 lar mechanisms by which shock wave treatment exerts its beneficial effects.

58 Aldosterone exerts its best known sodium homeostasis actions by cont

59 NC1 peptide was found to exert its biologic effects through an activation of smal

60 SP released from the peripheral nerves exerts its biological and immunological activity via hig

61 Further analysis revealed that NDRG1 exerts its biological effect in Merkel cell lines by reg

62 The molecular parameters of how CDA-KLF1 exerts its biological effects have not been addressed.

63 lamic neurons and the biliary epithelium and exerts its biological effects on cholangiocytes by inter

64 Lactate exerts its biological effects via G-protein-coupled rece

65 element for living organisms, zinc (Zn(2+)) exerts its biological functions both intracellularly and

66 BDNF exerts its biological functions through its receptor Trk

67 which dopamine gates locomotion and cocaine exerts its canonical stimulant response.

68 study provides a novel mechanism by which HN exerts its cardioprotective and neuroprotective effects.

69 Mechanistically, TAK1 exerts its cardioprotective effect through activation of

70 alpha-granules to platelet surfaces where it exerts its catalytic activity.

71 of HSJ1 to bind ubiquitylated clients and to exert its chaperone activity.

72 aken together, our data indicate that NMNAT2 exerts its chaperone or enzymatic function in a context-

73 rcuits or the specific neurons via which ACh exerts its cognitive effects remain unknown, it is known

74 rcuits or the specific neurons via which ACh exerts its cognitive effects remain unknown, it is known

75 The protein exerts its control through interactions with the initiat

76 Our data support a model in which H2S exerts its cytoprotective effect on ISR signaling by ind

77 mine the underlying mechanism(s) by which PT exerts its cytotoxic effects in CRC cells.

78 We previously found that IGFBP-3 exerts its cytotoxic effects on A549 (p53 wild-type) cel

79 ing numerous cellular outcomes, p53 may also exert its decisive and versatile functions by controllin

80 isease (AD), and its protein product, ApoE4, exerts its deleterious effects mainly by influencing amy

81 an unexpected, cell-autonomous feature that exerts its detrimental, highly aggressive growth potenti

82 ch, the molecular mechanism by which arsenic exerts its diabetogenic effects remains unclear.

83 At which subcellular site(s) Nef exerts its different functions and how kinetics of membr

84 These findings thus illustrate PFOS exerts its disruptive effects on Sertoli cell function d

85 w ecdysone enters the CNS through the BBB to exert its diverse role in Drosophila brain development.

86 r, the molecular mechanism by which TNFalpha exerts its diverse effects on breast cancer subtypes rem

87 appreciation of how and in what contexts p53 exerts its diverse effects remains unclear.

88 he specificity of ZIP, as it was reported to exert its effect also in PKMzeta knock-out mice.

89 mechanisms by which a noncoding mutation may exert its effect and discuss future challenges and oppor

90 Although BMI1 is known to exert its effect in the nucleus via repression of 2 pote

91 ylation site, cg05126514 within the BSN gene exert its effect on CAD through central nervous system-l

92 EA appears to exert its effect on Ewing cells through a decrease in ph

93 es were absolutely required for TGF-beta1 to exert its effect on SMAD-binding sites.

94 s, indicating that therapeutic NAc-DBS might exert its effect through antidromic stimulation.

95 d H2 receptor agonists showed that histamine exerted its effect by activating the H1 receptor.

96 d clathrin-mediated endocytosis of AQP2, but exerted its effect in a cAMP, PKA and S256 phosphorylati

97 We found that miR-132 exerted its effect on aging HSCs by targeting the transc

98 arrest and cardiopulmonary resuscitation by exerting its effect via the perivascular pool of aquapor

99 o hexamer led us to conclude that the former exerts its effect allosterically.

100 We show that 16:4(n-3) exerts its effect by activating splenic F4/80(+)/CD11b(l

101 SFDA approved "epigenetic drug", Decitabine, exerts its effect by hypomethylating DNA, demonstrating

102 rated understanding of how the lipid bilayer exerts its effect has remained elusive.

103 owever the developmental stage at which CDX2 exerts its effect is unknown.

104 tion sites within the ABO gene and that SELE exerts its effect on CAD through immune, glycemic, and l

105 In contrast, BRCA2 exerts its effect on HR in human cells together with HsR

106 GD1a exerts its effect on OPCs by inducing their proliferatio

107 ression, our results suggest that the capsid exerts its effect on transcription in cis.

108 DAQ exerts its effect primarily on RGCs, whereas DAA induces

109 hing is known about the extent to which CodY exerts its effect through small regulatory RNAs (sRNAs).

110 These data suggest that NMI exerts its effect through tumor-targeted delivery of a M

111 The operon exerts its effect via an encoded transcription factor ca

112 on in these cells, confirming that quercetin exerts its effect via SIRT-1.

113 ithout involving the DNA repair pathways and exerts its effect via suppression of CDC25 phosphatase S

114 To determine where dopamine exerts its effect, we limited expression of dopamine sig

115 fy the molecular mechanism of how glypican 4 exerts its effect.

116 suggest that affirmation of core values may exert its effects by allowing at-risk individuals to see

117 presents a new mode through which Nogo-A may exert its effects in the central nervous system.

118 Methylphenidate is thought to exert its effects on cognition and emotion through limbi

119 However, we provide evidence that C1 may exert its effects only indirectly, namely via inducing C

120 ells and must be transported out of cells to exert its effects through activation of 5 specific cell

121 Here, testosterone may exert its effects through androgen receptor-mediated mec

122 Classically, Epac1 is thought to exert its effects through binding of cAMP leading to a c

123 E139 has been reported to exert its effects via enhancement of extracellular GABA

124 uclear factor kappaB (NF-kappaB) pathways to exert its effects, although the signal transduction mech

125 tral regulator HilD was essential for Pat to exert its effects.

126 RGS7 exerted its effects by controlling morphine-induced chan

127 More important, NC1-peptide exerted its effects by downregulating the expression of

128 Bilirubin exerted its effects by recruiting and dissociating speci

129 -expressing stem cells in crypts, but rather exerted its effects on intermediate progenitors, in part

130 d discrepancy, PF analysis revealed that FED exerted its effects through multiple JAK2-independent me

131 However, how HBL exerts its effects and whether it requires any host fact

132 osine kinases (SPHK1 and SPHK2), that mainly exerts its effects by binding to the following 5 GPCRs:

133 effects, which can last several months, and exerts its effects by specifically cleaving and inactiva

134 However, the mechanism by which it exerts its effects has been unclear.

135 Until now it was not known whether GABA exerts its effects in plants through the regulation of c

136 of the mechanisms by which GLP-1R activation exerts its effects in preventing or arresting experiment

137 S1P exerts its effects in S1P receptor-independent manner.

138 igated the molecular mechanisms by which NLK exerts its effects in SBMA.

139 WASP exerts its effects on actin dynamics through a multisubu

140 pproaches, we provide evidence that miR-iab4 exerts its effects on adult self-righting behavior in pa

141 However, it remains unclear whether MSA exerts its effects on cancer prevention by influencing a

142 re detailed knowledge about how hyperthermia exerts its effects on chemotherapy may illuminate ways t

143 In sum, our results suggest that TMEM106B exerts its effects on FTLD-TDP disease risk through alte

144 of USP19-ER, suggesting strongly that USP19 exerts its effects on fusion through its effects on UPR

145 in our experimental models suggest that iron exerts its effects on leptin by decreasing O-glycosylati

146 heral to the central nervous system and that exerts its effects on neurons by signalling through tyro

147 al a non-canonical mechanism by which GPR158 exerts its effects on stress-induced depression by the c

148 ffect: -2.70; p = 0.03), indicating that DUP exerts its effects on treatment response through affecti

149 of Lane et al. that successful psychotherapy exerts its effects through memory reconsolidation.

150 amic deep brain stimulation in tremor likely exerts its effects through modulation of both olivocereb

151 (LE-135) studies further confirmed that ATRA exerts its effects through RAR-beta.

152 A drug exerts its effects typically through a signal transducti

153 drolysis mutants, we show that, although ATP exerts its effects via binding AAA1, ADP effects are med

154 LRH-1 exerts its effects via multiple signaling networks.

155 owever, to date, no single therapeutic agent exerts its effects via perturbing heterotrimeric G prote

156 HuMC function, the mechanisms by which IL-6 exerts its effects, and the relationship of these findin

157 However, the mechanisms by which exercise exerts its effects, especially in humans, are not fully

158 We show that YY1 exerts its effects, in part, by promoting B-cell surviva

159 he view of how this important class of drugs exerts its effects.

160 d by which astrocyte [Ca(2+)]i is raised and exerts its effects.

161 ATRA-PLLA microparticles exerted its efficacy likely through degrading Pin1 and i

162 rase component that exists as a homodimer to exert its epigenetic function.

163 ns as a motor or as an actin cross-linker to exert its essential role is disputed [1, 4, 5].

164 ibitory pathways possibly preclude ETV1 from exerting its full oncogenic potential.

165 th ZapB and requires the presence of ZapB to exert its function in division.

166 e of N(6)-mA and the molecular pathways that exert its function remain unclear.

167 minimal distance required for HSET/KIFC1 to exert its function, highlighting a biphasic model for ce

168 al differentiation, but how this nucleoporin exerts its function and whether it modulates nuclear por

169 Uromodulin mainly exerts its function as an extracellular matrix whose ass

170 CLUH exerts its function by controlling the stability and tra

171 ter simulations, we propose that expectation exerts its function by modulating the intrinsically gene

172 ation of the canonical NF-kappaB pathway and exerts its function by recruiting the IkappaB kinases (I

173 MLL4 exerts its function by regulating transcriptional progra

174 How TIM4 exerts its function is unclear, and conflicting data hav

175 ghly interconnected miRNA regulatory network exerts its function less through any individual link and

176 pressor in mice and suggest that the protein exerts its function mainly by limiting the extent and du

177 We describe here how CrIND exerts its function on Capsella fruit shape by binding s

178 It primarily exerts its function through the generation of pyrophosph

179 At the molecular level, insulin exerts its function through the insulin receptor (IR), a

180 th characterization revealed that circCCDC66 exerts its function via regulation of a subset of oncoge

181 PRMT5 exerts its function when complexed with MEP50/WDR77.

182 It exerts its function, at least in part, through repressin

183 actual plant body part in which a transcript exerts its function.

184 Importantly, AtCPSF100 was found to exert its functions through the change of poly(A) sites

185 ivates the expression of its target genes to exert its functions.

186 both as a neurotransmitter and as a hormone, exerting its functions via dopamine (DA) receptors that

187 al mechanisms as to how linear polyubiquitin exerts its functions distinctly from those of other ubiq

188 T-cell tolerance, although how beta-catenin exerts its functions remains incompletely understood.

189 accumulated, suggesting that mutant p53 may exert its gain of function by altering iron metabolism.

190 Genistein exerted its gastroprotective effects through the reducti

191 is a general mechanism by which progesterone exerts its genome-independent action and primes sperm fo

192 PII-transcribed genes, suggesting that RECQ5 exerts its genome-stabilizing effect by acting at sites

193 dulation depended on the baseline SSA level, exerting its greatest effect on neurons with intermediat

194 the molecular mechanisms employed by YAP to exert its growth and oncogenic functions, and suggest st

195 s the TEAD1-YAP1 transcriptional complex and exerts its growth inhibitory control through its evoluti

196 Their findings indicate that p53 may exert its "guardian of genome" duties at least in part v

197 ent on a cognate, Ag-specific interaction to exert its immunomodulatory effects on arthritis developm

198 teroides acidifaciens population, indirectly exerting its immunomodulatory effect on the intestine.

199 ivities suggested to us that DeltaEGFR might exert its influence through pleiotropic effectors, and w

200 rther mechanistic studies revealed that SHP2 exerted its influence partly by regulating the abundance

201 uron activity, but the circuitry by which it exerts its influence remains poorly described.

202 n beta(7) function, suggesting that syndecan exerts its influence, at least in part, by coordinating

203 gma(54) targets different regions in RNAP to exert its inhibitory function.

204 ATP exerted its inhibitory effect through the activation of

205 nt BTK kinase inhibitor (CHMFL-BTK-11) which exerted its inhibitory efficacy through a covalent bond

206 cAMP for the same binding region; rather, it exerts its inhibitory action through an allosteric mecha

207 us studies have therefore suggested that MT2 exerts its inhibitory effect by inactivating HJV.

208 ays with these variants revealed that Cyt1Aa exerts its insecticidal activity and hemolysis through d

209 e cellular response to environmental cues by exerting its kinase activity on multiple substrates(1-3)

210 ll the yeast host, indicating that the toxin exerts its lethality through its enzyme activity.

211 it has been widely held that streptolysin S exerts its lytic activity through membrane disruption, i

212 Interestingly, STS exerted its metabolic benefit through sex-specific mecha

213 s exploits pre-existing chromatin looping to exert its multimodal role.

214 linker histone H1, similar to core histones, exerts its multiple biological functions through indepen

215 We propose that GABA exerts its multiple physiological effects in plants via

216 standing of the mechanisms through which PAG exerts its negative-regulatory role in TCR signaling.

217 Sp8 exerts its neural patterning activities by acting as a t

218 The homodimer NGF (nerve growth factor) exerts its neuronal activity upon binding to either or b

219 CA appears to exert its neuroprotective effects through inhibition of

220 Abeta may exert its neurotoxic effects via multiple mechanisms and

221 elucidate possible mechanism(s) by which Se exerts its neurotoxicity.

222 of the V3 loop and suggest that the antibody exerts its neutralization effect by blocking the corecep

223 tope in the so-called "rim" domain of AT and exerts its neutralizing effect through a dual mechanism.

224 tastasis-associated phosphatase, is known to exert its oncogenic functions through activation of PI3K

225 Mechanistically, ATDC exerted its oncogenic effects by suppressing miR-29 and

226 results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downr

227 The best-understood mechanism by which EZH2 exerts its oncogenic function is through polycomb repres

228 ed by BCAT1 knockdown, indicating that BCAT1 exerts its oncogenic function through BCAA production in

229 Mechanistically, METTL14 exerts its oncogenic role by regulating its mRNA targets

230 These results suggest that the CNV may exert its opposing influences through mechanisms that in

231 tative RT-PCR analyses revealed that adjudin exerted its otoprotective effects by up-regulating the l

232 sor for other steroid hormones, pregnenolone exerts its own effect as an anti-inflammatory molecule t

233 ons in the nucleocytoplasmic transport while exerts its pathogenic effect by sequestering RAN.

234 in apoptosis and the mechanism by which PS1 exerts its pathogenic effects.

235 he underlying mechanisms through which ENPP1 exerts its pathological effects.

236 asmic membrane of eukaryotic cells, where it exerts its phospholipase A2 activity upon interacting wi

237 Glucagon exerts its physiological functions through activation of

238 Pioglitazone exerted its positive effect by inhibition of glycogen sy

239 Sugar exerts its potent reinforcing effects via both gustatory

240 found in red wine that has been suggested to exert its potential health benefit through the activatio

241 urthermore, the exact mechanism by which NCX exerts its potentially proarrhythmic effect, ie, by prom

242 cell biological assays to show that CX-5461 exerts its primary cytotoxic activity through topoisomer

243 its Toll/interleukin-1 receptor (TIR) domain exerts its pro-neurodegenerative action through NADase a

244 cific transcription factor Myt1-like (Myt1l) exerts its pro-neuronal function by direct repression of

245 on which has led to the suggestion that H2 S exerts its pro-nociceptive effects via this channel, sin

246 ollectively, the data indicate that TGF-beta exerts its profibrotic action in vitro and in vivo via i

247 investigated the mechanism by which TGF-beta exerts its profibrotic effects and specifically the role

248 ompetitive pressure, allowing TcdB to freely exert its profound effect, leading to increased mucosal

249 We conclude that NT exerts its proinflammatory and proangiogenic effects dur

250 stasis; however, the mechanism by which CAIX exerts its prometastatic function is not well understood

251 wledge of the mechanisms by which the plasma exerts its promising anti-cancer effects.

252 low us to propose a mechanism by which Psb28 exerts its protective effect on the RC47 intermediate.

253 -induced itch supports the notion that IL-31 exerts its pruritic effect indirectly via keratinocytes

254 icotinic acetylcholine receptors (nAChRs) to exert its psychoactive effects.

255 Sunitinib exerts its regenerative effects via transient inhibition

256 Rp29 must interact with the KDEL receptor to exert its regulation of ENaC biogenesis.

257 Although RsmA is thought to exert its regulatory effects by binding full-length tran

258 or of IFN signaling, which was also shown to exert its regulatory function in an isopeptidase-indepen

259 importance, we show that NC1 domain peptide exerted its regulatory effect by disorganizing actin mic

260 bserved in cd69(-/-) mice, showing that CD69 exerts its regulatory function within the lymphocyte com

261 an intermediary regulator through which agr exerts its regulatory function.

262 MITF exerts its regulatory functions through its association

263 eIF4A2 exerts its repressive effect by binding purine-rich moti

264 wth inhibitor in the central nervous system, exerting its repulsive activity by binding the Neogenin

265 Nod1 may exert its restrictive role by altering macrophage polari

266 Morphine exerts its rewarding actions, at least in part, by inhib

267 To exert its role of a functional polymer, DNA relies on a

268 CUL3 exerts its roles by pairing with approximately 90 distin

269 The protein exerts its scavenging action by hydrolyzing oxidized nuc

270 he membrane-anchored CX3CL1 is best known to exert its signaling function through binding its recepto

271 We propose that Jmjd6 exerts its splice modulatory function by interacting wit

272 The cis-elements through which each homolog exerts its splicing activities are likely to be highly s

273 In order for USP13 to exert its stabilizing effect on Aurora B, their associat

274 ability, implying that GTP acts elsewhere to exert its stabilizing influence on microtubule polymer.

275 osaccades is deeper than previously thought, exerting its strongest effects within the foveola.

276 ing as opposed to visual processing, that it exerts its strongest influence on spatial choices when d

277 ic suppressor of inflammatory responses that exerts its suppressive function by regulating transcript

278 The microbiome exerts its systemic effect through a diverse range of me

279 BYL719 exerts its therapeutic effect by suppressing AKT and oth

280 is (ECP) is thought to contribute to how ECP exerts its therapeutic effect in patients with chronic g

281 t can manipulate when, where, and how a drug exerts its therapeutic effect.

282 Our data suggest that anti-CD48 mAb exerts its therapeutic effects by both limiting CD4(+) T

283 thway is a novel mechanism by which ketamine exerts its therapeutic effects on stress-induced cogniti

284 pecific mechanisms through which NAcc volume exerts its therapeutic effects.

285 onsequently, we hypothesize that deguelin is exerting its toxic effect on nematodes as a modulator of

286 DTA exerts its toxic activity through inhibition of eukaryot

287 ogical and molecular mechanisms by which TCS exerts its toxicity, especially in early stages of liver

288 CBT-I may exert its treatment effects on PI by reducing hyper-resp

289 ionally suggest that TGF-beta/SMAD signaling exerts its tumor suppressive activity, at least in part,

290 y cancer and a new mechanism by which PRDM16 exerts its tumor suppressive effects.

291 The retinoblastoma (Rb) protein exerts its tumor suppressor function primarily by inhibi

292 Finally, we identify that AEBP1 exerts its tumor-promoting effects by mainly activating

293 Mechanistically, miR-203 exerts its tumor-suppressive effect by directly targetin

294 Overall, our work indicates that TIF1gamma exerts its tumor-suppressive functions in part by promot

295 ome epithelioid but not vice versa; and ZEB1 exerts its tumorigenic effects by promoting cell dediffe

296 duce local complement activation rather than exert its typical role of inhibition.

297 atomic-level understanding of how methadone exerts its unique function in pursuit of more accessible

298 l slow-wave-activity; (2) armodafinil cannot exert its wake-promoting effects when PZ(Vgat) neurons a

299 e shown that lorcaserin acts in the brain to exert its weight-reducing effects, but this has not yet

300 These data suggest that lorcaserin exerts its weight-reducing effects by decreasing attenti