ライフサイエンスコーパス: exert their

1 We also show that LCUFAs exert their action independently of their cellular uptak

2 citing mucosal lesions as long as the toxins exert their action on the epithelium.

3 nce more than 40% of the drugs on the market exert their action through these proteins.

4 T2D loci (FTO, IRS1, KLF14 and PPARG) which exert their action via IR.

5 ork to understand how dietary phytochemicals exert their actions by binding to many functionally dive

6 e POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels.

7 GLP-1 and GIP exert their actions predominantly through unique G prote

8 However, how deacetylated FoxO exert their actions remains unclear.

9 However, it is unknown whether they exert their actions through shared regulatory mechanisms

10 g a neural mechanism through which SSRIs may exert their actions.

11 nia and Parkinson disease, and also to drugs exerting their actions via these sites.

12 ogenous RNAi triggers such as shRNAs ideally exert their activities exclusively via the antisense str

13 assays suggest that compounds 13, 62, and 70 exert their activities in the HAdV entry pathway, while

14 The compounds exert their activities on insects through neurotoxic eff

15 their antimalarial action and therefore may exert their activity by compromising Plasmodium mitochon

16 The sulfonylurea herbicides exert their activity by inhibiting plant acetohydroxyaci

17 Similar to AlkB, these homologues exert their activity on nucleic acids, although for some

18 ormous success as broad spectrum agents that exert their activity through dual inhibition of bacteria

19 e deacetylases both in vitro and in vivo and exert their activity through locus-specific alterations

20 h what degree of specificity CheR paralogues exert their activity.

21 families often request treatment as a way to exert their agency, avoid a sense of responsibility for

22 rough which low carbohydrate ketogenic diets exert their ameliorative effects still remain to be eluc

23 In conclusion, wine compounds may exert their anti-inflammatory activity by reducing PAF l

24 Statins exert their anti-inflammatory effects on the vascular wa

25 How MVs exert their anti-inflammatory effects or whether their t

26 pathways in which statins are implicated and exert their anti-inflammatory effects, and we focus spec

27 ding a molecular framework for how ceramides exert their anti-neoplastic activity.

28 ic studies that suggest that these compounds exert their anti-trypanosomal effects, at least in part,

29 Interferons (IFNs) exert their anti-viral effects by inducing the expressio

30 on-independent pathways, through which IMiDs exert their antiangiogenic effects.

31 ghly potent, broad-spectrum antibiotics that exert their antibacterial activity by selectively target

32 f action studies revealed these compounds to exert their antibacterial effects, at least in part, thr

33 lasses of naturally occurring antimicrobials exert their antibiotic activity by specifically targetin

34 target for developing therapeutic drugs that exert their anticancer activities by producing massive c

35 How DNA methylation inhibitors exert their anticancer effects in patients is not well u

36 In cell culture, MTAs exert their anticancer effects primarily by causing mito

37 rugs that specifically target alpha2-GABAARs exert their antihyperalgesic effect through enhanced spi

38 nic AMPs bind negatively charged bacteria to exert their antimicrobial activity.

39 xes currently studied in anticancer research exert their antiproliferative activity, at least partial

40 G-quadruplex ligands exert their antiproliferative effects through telomere-d

41 These electrophilic compounds are likely to exert their antitrypanosomal activity via inhibition of

42 the host factors that rely on SUMOylation to exert their antiviral effects, the enzymes that mediate

43 IFITMs typically exert their antiviral function by inhibiting the entry o

44 virus infection indicated that the compounds exerted their antiviral activities after the entry proce

45 out the mechanism through which these agents exert their anxiolytic effects at a brain level in gSP.

46 Ikaros transcription factor, synergistically exert their APC-promoting effects on the progenitors.

47 e why climate scientists should increasingly exert their authority in scientific and public discourse

48 e effector molecules of host immunity, which exert their bactericidal effects through damaging pathog

49 We demonstrate that UroA and UAS03 exert their barrier functions through activation of aryl

50 ough the mechanisms through which probiotics exert their beneficial effects are largely unknown.

51 symptoms of depression, and that treatments exert their beneficial effects by abolishing these biase

52 Mechanistically, MSCs exert their beneficial effects by release of paracrine f

53 However, the mechanisms by which omega-3s exert their beneficial effects has not been fully explor

54 g lines of evidence indicate that stem cells exert their beneficial effects mainly through secretion

55 stent with the idea that these interventions exert their beneficial effects, in part, by modulation o

56 cant mechanistic insight into how cyclotides exert their bioactivities.

57 ed sulfane sulfur compounds (H(2)S(n)), that exert their biological actions via cysteine S-sulfhydrat

58 ctins are carbohydrate-binding proteins that exert their biological activity by binding to specific c

59 stablished as stress signaling proteins that exert their biological effect by degrading the bacterial

60 hin the native cytoplasm where they normally exert their biological effect.

61 which nucleic acid sensors are activated and exert their biological effects in the context of various

62 al through the JAK/STAT signaling pathway to exert their biological effects.

63 Many RNA molecules exert their biological function only after folding to un

64 al products that recognize RNA specifically, exert their biological functions by binding to prokaryot

65 unknown mechanisms used by these proteins to exert their biological functions.

66 compartments are of paramount importance to exert their biological functions.

67 and paralogs ensures that miRNAs efficiently exert their biological impact.

68 ole in worsening dysfunction of the other by exerting their biologically harmful effects, leading to

69 of ITCs, which in part may explain how they exert their cancer-preventive effects.

70 methods based on auto-encoder algorithm can exert their capability in knowledge learning in order to

71 e-derived peptides, like ZIP, are thought to exert their cellular action primarily by inhibiting PKC

72 Regulatory RNAs exert their cellular functions through RNA-binding prote

73 og P < 1.9) from hydrophobic substances that exert their chaotropic activity, by proxy, from within t

74 s whereby lycopene and other carotenoids may exert their chemoprotective effects, we and others perfo

75 onstitute effective cell therapy for OI, but exert their clinical impact by different, complementary

76 rently accepted notion that hybrid NO-NSAIDs exert their cytoprotective effects by releasing NO.

77 t amyloid fibrils and oligomers assemble and exert their cytotoxic effect at cellular membranes, rath

78 ompounds (e.g., quinazolinediones, QDs) that exert their cytotoxic effects by modulating ROS-mediated

79 ies have suggested that thiopurine drugs may exert their cytotoxic effects partly through binding of

80 h the cytosol of mammalian cells, where they exert their cytotoxic effects.

81 n machinery to reach the cytosol, where they exert their cytotoxic effects.

82 sion of the MHC-I complex in motoneurons and exerts their cytotoxic function through Fas and granzyme

83 ing indirect evidence suggests that MTAs may exert their cytotoxicity in human tumors by interfering

84 are internalized to intracellular space and exert their cytotoxicity via an unknown mechanism.

85 oxins exploit host cell mechanisms to enter, exert their deleterious effects as well as hijack host n

86 olecular mechanisms by which these mutations exert their deleterious effects on the glomerulus remain

87 oth hyperglycemia and increased RAS activity exert their deleterious effects, highlighting the therap

88 These cells exert their detrimental functions by promoting tumor gro

89 pathways by which the oligosaccharides might exert their direct immunomodulatory effect are summarize

90 s revealed that a significant proportion are exerting their disease risk through islet-cell dysfuncti

91 ce several biologically active peptides that exert their downstream effects by activating distinct si

92 ular mechanisms by which association signals exert their effect and (2) suggests that salt sensitivit

93 d mechanism through which dominant mutations exert their effect and cause disease.

94 ession, yet the rules by which these regions exert their effect are poorly understood.

95 s linked to the protective variant rs2647012 exert their effect by a cis-regulatory mechanism involvi

96 These Abs likely exert their effect by activating antiviral effector cell

97 , we found that doxycycline and rifamycin SV exert their effect by binding to oligomeric species both

98 class of putative physiological activators, exert their effect by changing membrane properties, lead

99 ntivirals, notably nucleoside analogs (NAs), exert their effect by incorporation into viral genomes a

100 Traditional inotropic agents exert their effect by modulating calcium signaling in th

101 Epigenetic modifications may exert their effect independently or complementary to gen

102 Epigenetic modifications may exert their effect independently or complementary to gen

103 he mechanism by which most sequence variants exert their effect on blood cell formation remains elusi

104 l regulatory role (SF3A3, ILF3, and N4BP2L2) exert their effect on CAD through height.

105 Phospholipids could exert their effect on membrane protein topology either d

106 ealed how common cancer-associated mutations exert their effect on telomerase after cells differentia

107 trophic cardiomyopathy (HCM) are proposed to exert their effect through gain of function for missense

108 We show that imidazopyrazines exert their effect through inhibitory interaction with t

109 In a mathematical model, perturbations often exert their effect through parameters, so sizes and shap

110 We additionally demonstrated that protons exert their effect through sensitization of PLCdelta1 to

111 How exactly they exert their effect, in particular in patients with low c

112 nical pathways whereby several of our probes exert their effect.

113 impair peripheral allergen sensitization but exerted their effect at the lung allergen challenge phas

114 Myelin-specific Foxp3(+) Tregs exerted their effect both by diminishing Ag-bearing infl

115 mune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and I

116 st home successfully to the genital tract to exert their effector function and decrease C. trachomati

117 then reactivated to remain in the tissue and exert their effector function only if they encounter the

118 ry CD8 T cells inside tumor were not able to exert their effector functions and influence tumor progr

119 To better understand how these factors exert their effects and shape glial expression programs,

120 s are needed to understand how these factors exert their effects and to determine if these factors ar

121 s to determine at what regulatory level they exert their effects and to what extent they can compleme

122 , although the mechanisms through which they exert their effects are complex, affect all four domains

123 Furthermore, the compounds exert their effects at the alpha2-adrenoceptor both in v

124 er's disease, but it is unknown whether they exert their effects by altering cognitive trajectory in

125 Drugs of abuse exert their effects by exploiting natural neurobiologica

126 Cytotoxic drugs that cause CIPN exert their effects by increasing oxidative stress, whic

127 diac surgery, but it is unclear whether they exert their effects by modifying the myocardial redox st

128 SSRIs may exert their effects by remediating emotion regulatory br

129 Recent evidence shows that many MAPs exert their effects by selectively binding to distinct c

130 is not known whether these genetic variants exert their effects in younger individuals.

131 and GPR103 form functional hetero-dimers to exert their effects involving activation of ERK1/2.

132 he mechanisms through which anticancer drugs exert their effects is essential to improve combination

133 How these polymorphisms exert their effects is poorly understood.

134 We further showed that Cav-1 and LRP6 exert their effects on Akt and glycolytic activities by

135 previously intractable human diseases but to exert their effects on cellular RNA processing they must

136 ve our understanding of how genetic variants exert their effects on complex traits and disease.

137 hich variants underlying association signals exert their effects on disease.

138 In other cell types, coronins exert their effects on lamellipodia dynamics by an inhib

139 re no longer necessary but might continue to exert their effects on recipient cells.

140 General anesthetics exert their effects on the central nervous system by act

141 nding of the mechanisms by which these drugs exert their effects remained elusive.

142 Thyroid hormones exert their effects through alpha (TRalpha1) and beta (T

143 enetic predispositions to obesity may partly exert their effects through appetitive traits reflecting

144 General anesthetics (GAs) exert their effects through endogenous sleep-wake contro

145 of large amounts of PGs, such as PGE2, that exert their effects through EP receptors and other intra

146 own to demonstrate that transport inhibitors exert their effects through inhibition of FABPs, thereby

147 s that the neuroblastoma-associated variants exert their effects through loss or gain of protein-prot

148 a majority of disease-associated variants to exert their effects through pancreatic islet dysfunction

149 Whether these additional gene products exert their effects through the CCK2 receptor or a separ

150 Glucocorticoids exert their effects through the glucocorticoid receptor

151 butyrylated lower molecular mass hyaluronans exert their effects through the TLR-4 receptor system.

152 , have roles in metabolic regulation and may exert their effects through this mechanism.

153 that even seemingly intuitive mutations can exert their effects through unforeseen and complex inter

154 factors for dental caries do not necessarily exert their effects uniformly across all tooth surfaces.

155 ric modulators are ligands for proteins that exert their effects via a different binding site than th

156 that have been functionally dissected, most exert their effects via a direct interaction with either

157 In vitro studies have shown that plexins exert their effects via an intracellular R-Ras/M-Ras GTP

158 h it was generally assumed that H(2)S and NO exert their effects via separate pathways, the results o

159 These mutations exert their effects via the RAS/MAPK and the PI3K/AKT pa

160 They exert their effects via their binding to the active site

161 Here we show that RAF inhibitors exert their effects via two distinct allosteric mechanis

162 dentify two mechanisms that ILC3s utilise to exert their effects within intestinal tissue.

163 These metabolites exert their effects within the host as signalling molecu

164 -based phenotypic screening strategies might exert their effects would be highly augmented by new app

165 urveys the proposed mechanisms by which they exert their effects, from the nucleus to the cellular me

166 to provide insight into how corticosteroids exert their effects.

167 both drugs share a binding pocket in SUR1 to exert their effects.

168 a likely mechanism by which these compounds exert their effects.

169 rmacological and psychological interventions exert their effects.

170 riants alter transcription factor binding to exert their effects.

171 dentifying pathways through which treatments exert their effects.

172 TMDs) and how TMD-targeting allosteric drugs exert their effects.

173 itself, we studied whether iron or TGF-beta exerted their effects through alternative mechanisms, su

174 he effect of KCNE3 on KCNQ1 channels, mainly exerting their effects by an electrostatic interaction w

175 ase risk may result from regulatory variants exerting their effects only in the presence of immune st

176 After exerting their effects, they are eliminated in the urine

177 In conclusion, the majority of envirome exerts their effects in a dynamic network via transitive

178 gs are diffused from the carrier systems and exert their efficacies under various clinical conditions

179 efects of hypoxia sensing and EPOR mutations exert their EPO hypersensitivity.

180 wever, little is known about how EMILINs may exert their extracellular functions.

181 Protons exert their facilitation effect through Ca(2+) -dependen

182 ns are not sufficient for glucocorticoids to exert their full anti-inflammatory effects and suggest t

183 d by the anti-diabetic sulfonylurea drugs to exert their full glucose-lowering effects.

184 Frequently, proteins do not exert their full potential as monomers but rather underg

185 secondary cell wall thickening, but how they exert their function and how their expression is regulat

186 types in genome-wide association studies may exert their function by altering expression of eQTL gene

187 Cytokines exert their function by binding specific receptor comple

188 In human neutrophils, PSMs exert their function by binding to the formyl peptide re

189 They exert their function by delivering bacterial effector pr

190 Hox proteins exert their function by interaction with TALE transcript

191 mato leaf dissection, require Tf activity to exert their function in the basal part of the leaf.

192 N-1/Nrf1, ATG-18/WIPI1/2 and ATG-16.2/ATG16L exert their function through the DAF-16/FOXO transcripti

193 Riboswitches exert their function through the interplay of alternativ

194 ing list of cellular processes in which PKDs exert their function via phosphorylation of various subs

195 through which OA genetic risk polymorphisms exert their functional effects.

196 mo-vascular precursors which require S1P1 to exert their functions and are essential for cardiac morp

197 Since miRNAs exert their functions by regulating the expression of th

198 RecQ helicases exert their functions by using the free energy of ATP hy

199 gene regulatory networks through which they exert their functions, and their physiological integrati

200 Sirt1, -6, and -7 exert their functions, predominantly, through a direct e

201 tissues in which susceptibility genes might exert their functions.

202 (lncRNAs) are constrained to the nucleus to exert their functions.

203 fection to uncover when, where, and how they exert their functions.

204 (caspofungin, micafungin, and anidulafungin) exert their fungicidal activity by inhibition of the syn

205 Oncogenic processes exert their greatest effect by targeting regulators of c

206 Clinical genetics and genomics will exert their greatest population impact by leveraging the

207 ines, that likely require MyD88 signaling to exert their growth-promoting activity, are prevented.

208 We hypothesized that AGPs exerted their growth promoting effect by altering gut mi

209 rticipate directly in aortic wall repair but exerted their healing properties through paracrine mecha

210 One emerging possibility is that anesthetics exert their hypnotic effects by hijacking endogenous aro

211 hitosan and digestion resistant maltodextrin exert their hypolipidemic activity by different mechanis

212 pecialized cell population highly adapted to exert their immune functions in the vascular network of

213 fector T cells; however, where and how Tregs exert their immunomodulatory effects remain poorly under

214 Regulatory T cells (Tregs) exert their immunosuppressive activity through several i

215 omerular diseases are glucocorticoids, which exert their immunosuppressive and direct podocyte protec

216 pathogens (bacterial drivers or alpha-bugs) exert their influence at low abundance by modulating bot

217 They exert their influence by guiding mRNA cleavage, translat

218 results suggest that SIX1/SIX6 gene variants exert their influence later in adult life.

219 ons and functional variants within STS might exert their influence on ADHD vulnerability, and disorde

220 and general principle whereby prior beliefs exert their influence on behavior by sculpting cortical

221 ssed in the brain suggesting that they might exert their influence on body weight through eating-rela

222 olecular basis through which these exposures exert their influence on children's health.

223 predictions generated in higher-level areas exert their influence on lower-level areas within an inf

224 dividual differences and partner experiences exert their influence on relationship quality via a pers

225 These results suggest that barriers may exert their influence on the cognitive map through organ

226 functional and the mechanisms by which they exert their influence remains largely unexplored.

227 e affinity of the TolB-ColE9 complex, do not exert their influence through long-range electrostatic e

228 nes, yet the extent to which recurrent SCNAs exert their influence through rearrangement of cis-regul

229 ponses, mitochondrial activity, and satiety, exerting their influence through signaling systems inclu

230 t and receptor-independent channel activity, exerting their influence, at least in part, by enhancing

231 Both of these factors appear to exert their influences within the first few years of lif

232 mechanism through which palytoxin congeners exert their inhalatory toxicity is still unknown, this r

233 icate that GIIA sPLA(2) selective inhibitors exert their inhibitory effects by binding to the hGIIA s

234 of the ovarian cycle during which estrogens exert their inhibitory feedback, it is required for the

235 l activity in vivo, while the glycooligomers exert their inhibitory function post attachment of virus

236 Drugs of abuse exert their initial reinforcing effects by triggering su

237 Sulfonylurea derivatives exert their insulinotropic effect by binding to the SUR1

238 rther reveals that EPAC2-specific inhibitors exert their isoform selectivity through a unique mechani

239 The mechanisms by which TFR cells exert their key immunoregulatory functions are largely u

240 uch as exercise and caloric restriction, may exert their known health benefits through the autophagy

241 gulated in their subcellular localization to exert their local function.

242 eg depletion mouse model, we found that Treg exert their main suppressive activity in the first 2 d a

243 ntly, we examined whether BDZ agonists could exert their modulatory effect by displacing the equilibr

244 ust both fold into a stable conformation and exert their molecular function.

245 ost factors exploited by bacterial toxins to exert their myriad biological effects.

246 ing a highly cytotoxic Abeta(25-35) peptide, exert their neurotoxic effect during Alzheimer's disease

247 ever, the mechanism by which these oligomers exert their neurotoxic effect remains unknown.

248 verstimulated ionotropic glutamate receptors exert their neurotoxic effects in part by overactivation

249 may be a new mechanism by which certain DTCs exert their neurotoxic effects.

250 ence that synthetic repellents may primarily exert their olfactory mode of action by decreasing the a

251 Whether AgRP neurons exert their orexigenic actions, at least in part, by inh

252 How they exert their pathogenic effect has, however, endorsed con

253 in neurodegeneration and that LRRK2 and tau exert their pathogenic effects through independent mecha

254 tributes substantially to how these variants exert their pathogenic effects.

255 stinal barrier and reach the blood stream to exert their physiological action.

256 Dinucleoside polyphosphates, Np(n)N', exert their physiological effects via P2 receptors (P2Rs

257 It is thought that PP-IPs exert their pleiotropic effects as allosteric regulators

258 rotease inhibitors of the Bowman-Birk family exert their potential chemopreventive and/or therapeutic

259 protective against colorectal cancer and may exert their preventative effects via modulation of the W

260 Our results demonstrate that MAPCs exert their primary effects in the periphery and provide

261 LL3 and MLL4 that are found in cancers could exert their properties through malfunction of these Trr/

262 cancer-associated mutations in MLL3 and MLL4 exert their properties through the malfunction of Trr/ML

263 c agents require activation of GCLC to fully exert their protective effect.

264 chanism(s) activated by these supplements in exerting their protective actions remain poorly understo

265 timately reach the cytosol, where the toxins exert their protein synthesis-inhibitory activity by dep

266 than a tetramer and that neither ADP nor ATP exert their regulatory effects by altering the oligomeri

267 odels for how PigR and the MglA-SspA complex exert their regulatory effects.

268 hma, but the anatomic location in which they exert their regulatory function and the mechanisms contr

269 ne the anatomic location at which Treg cells exert their regulatory function in the sensitization and

270 Recent findings have shown that NATs can exert their regulatory functions by acting as epigenetic

271 ation, when these molecules are available to exert their regulatory functions on the cell genome and

272 In the thymus, the recirculating cells exerted their regulatory function by inhibiting interleu

273 elevant effector through which beta-agonists exert their relaxant effects.

274 idence supports the paradigm that stem cells exert their reparative and regenerative effects, in larg

275 in interaction assays indicate that the PRRs exert their repressive activity by binding directly to t

276 We conclude that cis-expressed ligands exert their repressive effect on Notch signaling in case

277 of the dlPFC during controllable pain, both exerting their respective effects via the anterior insul

278 supports the idea that environmental factors exerting their role in childhood or adolescence may be o

279 dary organizers are established and how they exert their signaling functions.

280 in E3 ligases (CRL4s) were recently shown to exert their specificity through the binding of various s

281 These proteins exert their suppressive effects through the inhibition o

282 is how these different populations of Tregs exert their suppressive function in vivo.

283 kocytes--possess all of these properties and exert their targeting ability through cellular membrane

284 Benzodiazepines (BZDs) exert their therapeutic actions by binding to the GABA(A

285 Photosensitizers exert their therapeutic effect by producing reactive oxy

286 PARPi exert their therapeutic effects mainly through the block

287 chanisms by which these different treatments exert their therapeutic effects.

288 other exogenous and endogenous cannabinoids exert their therapeutic effects.

289 mingly limited "hit-and-run" mode to quickly exert their therapeutic impact, mediated by several mech

290 er stress conditions, allowing the toxins to exert their toxic effect.

291 classes of insecticides world-wide and they exert their toxic effects through interactions with the

292 (PD), although the mechanisms by which they exert their toxicity are not completely understood.

293 n viruses hijack this dislocation pathway to exert their toxicity or to infect cells.

294 of (GR)50, suggesting that (PR)50 and (GR)50 exert their toxicity through partially distinct mechanis

295 ndicating that selenide and selenomethionine exert their toxicity via distinct mechanisms.

296 athways and downstream targets by which they exert their tumorigenic effects remain elusive.

297 dings imply that proto-oncogenic eIFs likely exert their tumorigenic function by regulating/altering

298 current understanding of how biased ligands exert their unique pharmacology, and how research into G

299 It is believed that adult-born neurons exert their unique role in information processing due to

300 asked whether or not these two neurotrophins exert their unique roles on the gustatory system by regu