1 the total number of kiwi taxa that currently
exist to 11 and the number that existed just before huma
2 onditions, the open-ring merocyanine (MC(-))
exists to 48% and closes quantitatively by irradiation w
3 chemistry, yet few enantioselective methods
exist to access this scaffold.
4 While many strategies
exist to achieve tethering of peptides, protein, and sma
5 mia events, until recently, no precise tools
existed to actively interrogate cardiac dynamics in spac
6 mains a major challenge, and no technologies
exist to adequately interrogate the >1 x 10(6) B cells i
7 Significant barriers
exist to adopting these systems, however, and a diversit
8 Impactful research opportunities
exist to advance understanding of IDPM, and to incorpora
9 es derived from randomized controlled trials
exist to aid clinical decision-making, and the findings
10 Minimal normative baseline data
exist to aid decision making in clinical and athletic se
11 However, limited evidence
exists to aid clinical decision making regarding which p
12 However, no publicly available tools
exist to analyse single-nucleotide polymorphism (SNP) ca
13 Various software tools
exist to analyze these pooled sequence data, yet little
14 However, no good method
exists to analyze this P-TEFb equilibrium in living cell
15 No accurate model of RC
exists to answer fundamental research questions relevant
16 Few instruments
exist to ascertain the severity of a preschool-aged chil
17 tions for individuals aged >=2 y and metrics
exist to assess alignment.
18 atrophy and dysfunction, and few techniques
exist to assess diaphragmatic function: the purpose of t
19 However, no agreed measures
exist to assess the scale and scope of the private healt
20 No widely available parameter
exists to assess global lung stress.
21 Insufficient evidence
exists to assess the possible benefits for suicide preve
22 ighlights the significant knowledge gap that
exists to assess the potential human health hazards asso
23 However, no non-invasive technique
exists to assess this key biological process.
24 tura to enter trance states, little evidence
exists to associate it with rock art.
25 While several algorithms
exist to automate parameter selection, each depends on g
26 ment options available, increased imperative
exists to better characterise patients to enable a perso
27 An important need
exists to better understand and stratify kidney disease
28 that conserved RNAPII-associated mechanisms
exist to both suppress intragenic cryptic promoters duri
29 Consequently, many modeling frameworks
exist to capture microbial population growth measurement
30 in instrument raw data files, an opportunity
exists to capture this metadata more accurately.
31 ress in tackling them to date, opportunities
exist to change future trajectories through transformati
32 ber of noninvasive tests and scoring systems
exist to characterize NAFLD and NASH, liver biopsy is th
33 While procedures
exist to characterize the viability of cells, most metho
34 However, little empirical evidence
exists to characterize the potential health benefits fro
35 cause of hypertension, no standard criteria
exist to classify surgical outcomes.
36 entification or pan-genome analysis, but few
exist to combine the two functions.
37 The results appear reasonable but no data
exist to compare with except those from dynamical mean-f
38 Not enough evidence
exists to compare buprenorphine-naloxone with extended-r
39 We propose that this asymmetry
exists to compensate for inherent and variable time dela
40 Currently, no unified framework
exists to comprehensively describe these photophysical p
41 sks; for other industrial chemicals, no data
exist to confirm their safety because of flaws in 1976 T
42 ike), but no direct experimental observation
exists to confirm this picture.
43 ermatologist's examination, no reliable tool
exists to confirm whether a patient has CLE for use in e
44 whether central circuit specializations also
exist to control their propagation through visual pathwa
45 While laboratory practice standards
exist to control this variability, the disparities betwe
46 ine or effective antiviral therapy currently
exists to control RSV or HMPV infections.
47 wever, additional proteolytic mechanisms may
exist to cope with the diversity of protein obstacles.
48 Cellular enzymes
exist to cope with these structures whose stable accumul
49 No targeted therapies
exist to counteract Hyperoxia (HO)-induced Acute Lung In
50 ed in space and time, but whether mechanisms
exist to couple the actin and microtubule (MT) cytoskele
51 t is important to understand what mechanisms
exist to curb unwanted activation.
52 No HIV-1 Vif-APOBEC3 costructure
exists to date despite extensive research.
53 ght-loss effects of cold-activated human BAT
exists to date.
54 nt options, but no targeted therapy for LQTS
exists to date.
55 Moreover, no theory presently
exists to derive city size distributions from fundamenta
56 Currently, a number of models
exist to describe allosteric behavior, taking into accou
57 clinical importance, but no tools currently
exist to describe the fine spatial organization of myeli
58 No systematic algorithms or heuristics
exist to detect and filter batch effects or remove assoc
59 While several tools
exist to detect and remove low-quality cells in one sing
60 Several algorithms
exist to detect CNVs by analyzing whole genome sequencin
61 Tests
exist to detect endotoxin in bodily fluids, but are expe
62 It is therefore plausible that circuits
exist to detect gut microorganisms and relay this inform
63 Methods
exist to detect residual confounding in epidemiologic st
64 While a large range of techniques
exist to determine a multitude of properties of these pa
65 Opportunities
exist to determine best practices around appropriate use
66 lthough several feature selection approaches
exist to determine the ancestry proportion in two-way ad
67 Although pathologic methods
exist to determine tissue type during surgery, these met
68 apy trials are underway, a future imperative
exists to determine which carriers require intervention
69 Opportunities
exist to develop a cheap assay to sequence a small numbe
70 However, limited data
exist to directly compare outcomes with belatacept-based
71 rom chiral starting materials, fewer methods
exist to directly synthesize enantioenriched chiral alle
72 No decisive empirical data
exist to distinguish between these two competing models.
73 Significant opportunity
exists to document processes of engagement that reflect
74 eal valid, feasible, and reliable scar scale
existed to effectively assess the quality of postoperati
75 Although strategies
exist to efficiently generate large quantities of expand
76 oints composed of viral and cellular factors
exist to either maintain a latent state or initiate prod
77 Up to now no treatment
exists to eliminate the presence of these unpleasant vol
78 e statistical computing language R, packages
exist to enable a user to submit their analyses as jobs
79 No previously published method
exists to enable comparative analyses of enrichment leve
80 No early postnatal treatment strategies
exist to enhance neuroprotective potential of microglia.
81 ffinities, suggesting that additional motifs
exist to enhance PP2A:B56 binding.
82 c information, multiple biological processes
exist to ensure genome integrity.
83 No criteria
exist to establish when a neurological syndrome is patho
84 Several algorithms currently
exist to estimate expression from the raw amplification
85 st cancers in humans, yet no validated tools
exist to estimate future risks of developing keratinocyt
86 Multiple equations
exist to estimate glomerular filtration rate (GFR); howe
87 At present, no tools
exist to estimate objectively the risk of poor treatment
88 from two main factors: 1) no physical model
exists to estimate the loop entropies of complex intramo
89 No data
exist to evaluate how hepatectomy time (HT), in the cont
90 A number of assessment tools
exist to evaluate the impact of hearing loss, with littl
91 rface processes and climate, yet few records
exist to evaluate the interplay of these processes over
92 function and in disease; however, few tools
exist to examine the INM in living cells, and the INM-sp
93 n light of sexual dimorphisms in CVD, a need
exists to examine baseline cardiac differences in humans
94 though different macroevolutionary scenarios
exist to explain the Triassic origin and subsequent rise
95 metabolism for this amoeba but the potential
exists to exploit differentially expressed metabolic sig
96 ganic examples are known and strong interest
exists to extend the search for ferroelectric molecular
97 idome, but no automated lipid classification
exists to facilitate this partitioning.
98 ite their immense interest, no simple method
exists to gain insights into their cellular concentratio
99 Although unprecedented opportunities now
exist to gather data on an individual's -omics profile (
100 ical and alternative p38 activation pathways
exist to generate immune balance.
101 Given that mechanisms
exist to generate parts, patterning processes are requir
102 With MASC, a theoretical footing now
exists to generate and test computationally explicit pre
103 es that proposed that such a class of neuron
exists to generate the enhanced vergence velocities obse
104 Rationale: Few data
exist to guide early adjunctive therapy use in pediatric
105 tcomes in pediatric sepsis, but minimal data
exist to guide empiric therapy.
106 in clinical specimens; however, little data
exist to guide its optimal application to clinical pract
107 Few data
exist to guide the physical design of biocontainment uni
108 h care spending, although few objective data
exist to guide the prioritization of comparative effecti
109 Limited objective data
exist to guide the prioritization of prevention efforts
110 Limited published data
exist to guide the treatment of pancreas transplant reje
111 reatment paradigm is unknown and little data
exist to guide the withdrawal of anaesthetics in refract
112 At present, no similar consensus
exists to guide imaging and interpretation of pediatric
113 al cardiac arrest (OHCA), as little evidence
exists to guide policy-makers.
114 Little evidence
exists to guide secondary prevention in this population.
115 ase for which, to date, no effective therapy
exists to halt disease progression toward end-stage live
116 tients, and currently no effective treatment
exists to halt its progression.
117 re found in most prokaryotes, an opportunity
exists to harness the endogenous systems as convenient t
118 Currently, no reliable biomarkers
exist to help diagnose the severity of TBI to identify p
119 Thus, new opportunities
exist to help distinguish microglia in the brain and per
120 ssess the risk of the nodule being malignant
exist to help in the stratification of patients.
121 The potential for ACT1
exists to help heal refractory VLUs, but it faces additi
122 omic, communication and governance solutions
exists to help transform management.
123 A number of methods
exist to identify biases during sequencing or alignment,
124 No tools currently
exist to identify gene candidates responsible for predet
125 isability, but few multifactorial algorithms
exist to identify individuals at risk of future work dis
126 Currently, no available methods
exist to identify patients who will respond favorably to
127 sufficiently well by a linear model, methods
exist to identify the number and connectivity of a minim
128 However, few analytical tools
exist to identify which host species are likely to harbo
129 Hence, a pressing need
exists to identify alternative animal models that reflec
130 An urgent need
exists to identify more brown planthopper (Nilaparvata l
131 Insufficient research
exists to identify specific population subgroups that ar
132 rting in July 2018, but no measure currently
exists to identify the added sugar content of products a
133 cies of interest, however little information
exists to illustrate such differences.
134 An opportunity may
exist to improve CAD prevention efforts by integrating b
135 4) reactivity, and significant opportunities
exist to improve catalyst durability.
136 e, yet no effective pharmacologic treatments
exist to improve cognition.
137 Multiple actionable opportunities
exist to improve communication in the intensivist-led IC
138 Opportunities
exist to improve hospitals' performance of time-critical
139 Opportunities
exist to improve the quality and reporting of future sel
140 trial population, significant opportunities
exist to improve the quality of cardiovascular secondary
141 Multiple strategies
exist to improve violence prevention efforts, and health
142 Currently, no treatment
exists to improve semen quality in most infertile men.
143 Significant opportunity
exists to improve the utility of guideline implementatio
144 less costly options, substantial opportunity
exists to improve the value of care delivered to Medicar
145 RC increases among adolescents, a clear need
exists to incorporate messages about condom use specific
146 re not long, implying that opportunities may
exist to increase access by using the existing prescribe
147 Strategies
exist to increase access to surgery and to improve commu
148 Few effective community-based interventions
exist to increase HIV testing and uptake of antiretrovir
149 epresents a family of related complexes that
exist to increase the regulatory diversity and gene cont
150 However, the potential
exists to increase PhytOC levels to 1.16-2.17 x 10(6) to
151 While many algorithms
exist to infer a gene regulatory network, very few of th
152 in the therapeutic landscape, no robust data
exist to inform on the selection of patients for a speci
153 Limited data
exist to inform policy decisions about the most appropri
154 sequencing or alignment, yet not many tools
exist to interpret biases due to outliers.
155 isingly, although little sequence similarity
exists to known insecticidal proteins, efficacy tests us
156 continues to expand globally, opportunities
exist to leverage these technologies to support demand f
157 ndicate that specific multisynaptic circuits
exist to link movement, cognition, and affect to the fun
158 In particular, the possibility
exists to link high-resolution and accurately dated fire
159 f determining whether compensatory processes
exist to maintain performance in the face of fatigue.
160 hat negative regulators of this process also
exist to maintain the critical balance required for figh
161 on and imply that strong selection pressures
exist to maintain the fidelity of the viral genome durin
162 tiple mitochondrial quality control pathways
exist to maintain the health of mitochondria and ensure
163 hat some form of reproductive isolation must
exist to maintain the two genetic backgrounds locally co
164 Although different approaches
exist to map motifs to DNA sequences, a systematic evalu
165 Few instruments
exist to measure caregivers' functional status during a
166 A number of innovative methods
exist to measure cell-matrix adhesive forces, but they h
167 A number of methods
exist to measure different aspects of cell size, but eac
168 al and pathophysiology, no noninvasive tools
exist to measure this system in patients.
169 vous system circuits as long as methods have
existed to measure them.
170 No method
exists to measure large-scale translation of genes in un
171 However, no well-established method
exists to measure solute partition coefficients into pol
172 ated open source PFAS data analysis software
exists to mine these extensive data sets.
173 Several strategies
exist to mitigate As impacts on rice and each has its se
174 and cultural issues, but that opportunities
exist to mitigate its impacts by combining novel technol
175 ting that management opportunities currently
exist to mitigate near-term non-breeding habitat losses.
176 A wide range of platforms
exist to model and study disorders associated with sudde
177 Multiple approaches
exist to model patterns of space use across species, amo
178 of research, no clear quantitative framework
exists to model the fundamental processes responsible fo
179 nic diseases, substantial untapped potential
exists to modify the relation between chronological age
180 lation, suggesting that mechanisms do indeed
exist to modulate hormone receptor responses at the sing
181 Therefore, additional mechanisms may
exist to modulate MEK/ERK activity in favor of tumor cel
182 plex, it remains unknown if other mechanisms
exist to modulate the level of PP2Cs.
183 9 infection; however, no standards currently
exist to monitor fever using wearable peripheral tempera
184 cell adhesion; however, no rigorous approach
exists to monitor and quantify it accurately in the abse
185 However, in most countries, no surveillance
exists to monitor the change in pneumococcal OM incidenc
186 No imaging methodology currently
exists to monitor viable islet mass after clinical intra
187 completely lacking and authorities apply non-
existing to most stringent requirements.
188 Many challenges
exist to optimise efficacy, minimise toxicity, and broad
189 Several tools
exist to perform such analyses but most require a comput
190 Although alternative methods
exist to perform the unique chemistry of diazomethane, t
191 Multiple tools
exist to perform this transformation for coordinate-only
192 High calcium levels must
exist to permit catalytically active calcineurin to func
193 A variety of platforms
exist to phenotype cellular models, including convention
194 not straightforward, as spatial constraints
exist to position the laser beam and the objective lens
195 arget for which clinically available therapy
exists to potentially treat muscular dystrophy in DM1.
196 Both experimental and computational methods
exist to predict pathogenicity of human genetic variatio
197 Although many computational methods
exist to predict plant protein subcellular localization,
198 monitor multiple sclerosis, no imaging tools
exist to predict the evolution of disease and the effica
199 At present, no accurate method
exists to predict the development of PTSD symptoms upon
200 Peripheral tolerance mechanisms
exist to prevent autoimmune destruction by self-reactive
201 Moreover, no treatments
exist to prevent the development of epilepsy in those at
202 Currently, no effective therapies
exist to prevent these vascular disorders of pregnancy.
203 At present, no effective treatment
exists to prevent its development.
204 Limited evidence
exists to prevent retained surgical items by using data-
205 characterized in vitro, very few techniques
exist to probe RNA structures inside cells.
206 Various manufacturing techniques
exist to produce double-curvature shells, including inje
207 vaccines or licensed therapeutics currently
exist to protect humans against NiV or HeV.
208 An urgent need
exists to protect access to high quality intrapartum car
209 ses (Cas) are an adaptive immune system that
exists to protect bacteria and archaea from viruses and
210 Additionally, the need
exists to protect consumers who, out of medical or ethic
211 neonates and young children, but no vaccine
exists to protect this vulnerable population.
212 ounts of alcohol, although insufficient data
exist to provide advice about other levels of alcohol us
213 However, no single tool yet
exists to provide comprehensive alignment-based quality
214 al outcomes in RA, but insufficient evidence
exists to provide specific dietary advice.
215 Finally, a plan
exists to pursue more extended interlaboratory validatio
216 However, simple techniques do not
exist to quantify the contribution of capillary flux to
217 Different algorithms
exist to quantify the total intensity and position of a
218 ancer-related death worldwide, but no models
exist to readily investigate distant metastases that are
219 levels, we believe that sufficient evidence
exists to recommend routine measurement of serum urate l
220 Several methods
exist to reconstitute membrane proteins in lipid systems
221 However, few simulators
exist to recreate the dynamic interactions during real t
222 ate that two separate but redundant pathways
exist to recruit ESCRT-III proteins to the midbody.
223 ypes, suggesting that activation checkpoints
exist to reduce the initiation of autoreactive B cell re
224 The potential
exists to reduce radiation dose without compromising low
225 tandardized brain tumor imaging protocol now
exists to reduce variability and improve reliability.
226 echanism distinct from the IR-Akt-Foxo1 axis
exists to regulate glucose production.
227 vessels within peripheral nerve endoneurium,
exists to regulate its internal microenvironment essenti
228 t is unknown whether surveillance mechanisms
exist to reinforce this function.
229 means of identification, no method currently
exists to reliably establish the time since deposition o
230 At present, few methods
exist to remediate prion-contaminated land surfaces.
231 If perceptual mechanisms
exist to represent lifelikeness, then observers should b
232 few if any satisfactory long-term solutions
exist to resolve this serious unintended side effect of
233 proteins, indicating that redundant pathways
exist to respond to hepatocyte death.
234 most common infections in children, no tools
exist to risk stratify children with suspected CAP.
235 t conversions suggests that kinetic barriers
exist to safeguard cell-type identity.
236 nism, and additional temporal regulators may
exist to sculpt vascular topology.
237 findings indicate that, in vivo, mechanisms
exist to select against aneuploid cells.
238 Different techniques
exist to select personalized positive end-expiratory pre
239 It is not known whether specific mechanisms
exist to sense membrane area and adjust channel expressi
240 ctoparasitic mite Varroa destructor, no data
exist to show synergistic effects between these two stre
241 Limited evidence
exists to show that adding a third agent to platinum-dou
242 Unfortunately, no method
exists to simultaneously quantify these biomolecules in
243 Although no targeted therapy yet
exists to slow renal fibrosis, a number of important rec
244 rain predictions, but significant challenges
exist, to some extent because of the large range of scal
245 ffective if hospital space and personnel pre-
exist to staff the facility.
246 inal-binding proteins, mainly two mechanisms
exist to store the photon energy after photoisomerizatio
247 Although several methods
exist to study cell migration (such as Boyden chamber as
248 owever, few models of B lymphocyte infection
exist to study immune recognition of such cells.
249 servoir within B lymphocytes, but few models
exist to study KSHV-infected B cells other than the tran
250 Now that tools
exist to study mucus structures found throughout the oce
251 e stenosis, but no approved specific therapy
exists to substantially lower Lp(a) concentrations.
252 hest-risk settings, however, little evidence
exists to suggest ART availability and other efforts slo
253 No evidence
exists to suggest that zoledronic acid improves survival
254 Few population-based data
exist to support an association.
255 strate that specialized molecular mechanisms
exist to support growth demands in neurons with large de
256 study group was that data does not currently
exist to support specific evidence-based model selection
257 alternative routes for NAD regeneration must
exist to support the increased glycolytic rate while all
258 Emerging data
exist to support the notion that SRS in combination with
259 has been undertaken to determine if evidence
existed to support these findings.
260 Reasonably consistent evidence
exists to support higher absolute BMR/RMR and TDEE in pu
261 facility use; however, insufficient evidence
exists to support its use over standard clinical care.
262 Substantial evidence now
exists to support that formation of DNA G-quadruplexes (
263 However, little guidance
exists to support the development of best-practice princ
264 While evidence
exists to support the effectiveness of neuraminidase inh
265 However, surprisingly little evidence
exists to support the idea that synaptic plasticity in p
266 Insufficient evidence
exists to support the management of the disconnected lef
267 tality, we conclude that verifiable evidence
exists to support the planning of emergency measures.
268 Level 1 evidence
exists to support the use of nivolumab as second-line tr
269 after drug-eluting stents, limited evidence
exists to support these recommendations.
270 eets, but no direct molecular-level evidence
exists to support this interpretation.
271 No evidence
exists to support this threshold.
272 men in developing countries, but no evidence
exists to support whether they could be implemented or e
273 t in the skin, multiple, distinct mechanisms
exist to suppress oncogenic growth.
274 Thus, an additional supply pathway(s) must
exist to sustain cone-dependent vision.
275 Unfortunately, no drugs
exist to target SARM1.
276 A new therapeutic agent now
exists to target further heart rate lowering in patients
277 Limited cellular platforms
exist to test endocrine disrupting chemical-induced deve
278 Several barriers
exist to the development and expansion of palliative car
279 Moreover, numerous barriers
exist to the implementation of screening and counseling,
280 However, serious obstacles
exist to the optimal management of the entire spectrum f
281 A range of methods
exist to these ends, but a lack of inter-study comparabi
282 However, so far, no methods
exist to track such representations in humans during act
283 Few methods
exist to track the sources of DON in watersheds.
284 Unfortunately, few resources
exist to train operators in PCI complication management.
285 Mechanisms must also
exist to transiently disassemble t-loops to allow accura
286 An enormous opportunity
exists to transition focus from intervention to providin
287 shed research priorities, an opportunity now
exists to translate the call for action into a global de
288 treatment, and research, an opportunity now
exists to translate this Declaration into an action plan
289 us system (CNS), yet few therapeutic options
exist to treat them.
290 No licensed vaccine or therapeutic
exists to treat MHF, and MARV is therefore classified as
291 uently, no pharmacological therapy currently
exists to treat NASH.
292 currently no approved therapeutic or vaccine
exists to treat or prevent LASV infections.
293 However, no techniques
exist to unambiguously identify these cell types, greatl
294 However, little evidence
exists to understand how migrant parents, who are typica
295 Limited information
exists to understand resource selection of mule deer in
296 en micelles through the water, opportunities
exist to use enzymes to effect secondary processes.
297 Nevertheless, little data
exist to validate the usefulness of kidney biopsies in t
298 Considerable scope
exists to vary the physical and chemical properties of n
299 Few tools
exist to visualize and manipulate neurons that are targe
300 However, no tool
exists to visualize the predicted tolerance of the genom