ライフサイエンスコーパス: exocrine pancreas

1 s important to the proper development of the exocrine pancreas.

2 ymphocytic and plasmacytic infiltrate in the exocrine pancreas.

3 ed state and then can form new endocrine and exocrine pancreas.

4 nce of the differentiated state of the adult exocrine pancreas.

5 the absence of differentiated endocrine and exocrine pancreas.

6 e protein present in zymogen granules of the exocrine pancreas.

7 omas (ACCs) are rare malignant tumors of the exocrine pancreas.

8 -induced rapid gating of water in ZGs of the exocrine pancreas.

9 Acinar cell carcinoma is a rare tumor of the exocrine pancreas.

10 tes and differentiation of the endocrine and exocrine pancreas.

11 zymogen granules, the secretory vesicles in exocrine pancreas.

12 uctular epithelial cell populations from the exocrine pancreas.

13 syntrophin specifically in the endocrine or exocrine pancreas.

14 n in the pancreatic secretory granule of the exocrine pancreas.

15 the inflammatory and metabolic needs of the exocrine pancreas.

16 mpede transcriptomic characterization of the exocrine pancreas.

17 that recapitulate properties of the neonatal exocrine pancreas.

18 e, and immune cells in intact lobules of the exocrine pancreas.

19 press proliferation causing repair damage of exocrine pancreas.

20 thood, with near-complete destruction of the exocrine pancreas.

21 es, including acinar and ductal cells of the exocrine pancreas.

22 as an oncogene in all three lineages of the exocrine pancreas.

23 capillary network between the endocrine and exocrine pancreas.

24 d quantitative model of cell dynamics in the exocrine pancreas.

25 characterized the effect of Fic loss on the exocrine pancreas.

26 nse hyperactivation and tissue injury of the exocrine pancreas.

27 of other diseases, including diseases of the exocrine pancreas.

28 that is distinct from those that inhabit the exocrine pancreas.

29 s that are scattered unevenly throughout the exocrine pancreas.

30 the pancreatic islets while being absent in exocrine pancreas.

31 nd complete neoplastic transformation of the exocrine pancreas.

32 t data suggest MEN1 may also function in the exocrine pancreas.

33 ntracellular cyclic AMP (cAMP) levels in the exocrine pancreas.

34 atic progenitors and derived lineages of the exocrine pancreas.

35 stigated the role of Bmi1 in regeneration of exocrine pancreas.

36 receptor liver receptor homolog-1 (LRH-1) in exocrine pancreas.

37 evention of alcohol-induced ER stress in the exocrine pancreas.

38 for the injurious effects of low pHe on the exocrine pancreas.

39 vely active form of the GTPase, Kras, in the exocrine pancreas.

40 (ER) is abundant in the acinar cells of the exocrine pancreas.

41 lar structures; such changes were lacking in exocrine pancreas.

42 they expand rapidly to form the bulk of the exocrine pancreas.

43 dependence as specific to endocrine, but not exocrine, pancreas.

44 rine disease, 3) metabolic influences on the exocrine pancreas, 4) genetic drivers of pancreatic dise

45 Bmi1 contributes to regeneration of the exocrine pancreas after cerulein-induced injury through

46 ated that disease states of the endocrine or exocrine pancreas aggravate one another, which implies b

47 inhibition of polyamine biosynthesis reduces exocrine pancreas and beta cell mass, and that these red

48 that would confer dual tissue specificity in exocrine pancreas and cytotoxic T lymphocytes are identi

49 y, rcl1-/- mutants exhibit a small liver and exocrine pancreas and die before 15 days post-fertilizat

50 ge-enhanced vacuolization and atrophy of the exocrine pancreas and exhibited keratin hyperphosphoryla

51 ein procolipase, which is synthesized in the exocrine pancreas and gastric mucosa.

52 ue to stimulate zinc secretion (SSZS) in the exocrine pancreas and imaging with a zinc-sensitive MRI

53 neighbors, which ultimately give rise to the exocrine pancreas and intestine.

54 ) to inhibit IL-17, thereby rescuing damaged exocrine pancreas and islet beta cells.

55 RT-PCR analysis of total RNA isolated from exocrine pancreas and islets shows that the gene is expr

56 s a lethal autoimmune syndrome involving the exocrine pancreas and other abdominal organs.

57 Over time, the exocrine pancreas and proximal tubules of the kidney als

58 ties exclusively in secretory organs such as exocrine pancreas and salivary gland that led to early p

59 d the endocrine pancreas but scarcely in the exocrine pancreas and skeletal muscle.

60 In contrast, the exocrine pancreas and the intestinal epithelium dediffer

61 herapy may induce focal proliferation in the exocrine pancreas and, in the context of exocrine dyspla

62 role for miR-26a in Ca(2+) signaling in the exocrine pancreas, and identify a potential target for t

63 ities, including extensive fibrosis, loss of exocrine pancreas, and islet disorganization.

64 nriched in purified islets compared with the exocrine pancreas, and islet-specific expression of p16I

65 s, dynamic topographies in the endocrine and exocrine pancreas, and principles of morphologic organiz

66 n terminal differentiation of the intestine, exocrine pancreas, and retina.

67 receptors for TNFalpha are expressed in the exocrine pancreas, and whether pancreatic acinar cells r

68 Diseases of the exocrine pancreas are often associated with perturbed di

69 Carcinomas of the exocrine pancreas are poorly understood and have a poor

70 we report an unexpected role for SHP in the exocrine pancreas as a modulator of the endoplasmic reti

71 functions of the different cell types in the exocrine pancreas as well as the roles of these molecule

72 nt in the secretory compartment of the human exocrine pancreas, as judged by immunogold electron micr

73 creatitis is an inflammatory disorder of the exocrine pancreas associated with tissue injury and necr

74 3 (ST3, matrix metalloproteinase 11) in the exocrine pancreas at metamorphic climax.

75 esulted in a 90% decrease in the size of the exocrine pancreas, because of decreased cellular prolife

76 A genuine understanding of human exocrine pancreas biology and pathobiology has been hamp

77 cytokines induced by viral infection of the exocrine pancreas but not of the beta-cells.

78 Ptf1a morphants lack differentiated exocrine pancreas, but maintain normal differentiation a

79 r the early development of the endocrine and exocrine pancreas, but whether Hh signaling functions in

80 zSMCTn is expressed in exocrine pancreas, but zSMCTe is not.

81 riductal and parenchymal inflammation of the exocrine pancreas by CD4(+) T cells, CD8(+) T cells, and

82 diates basolateral bicarbonate influx in the exocrine pancreas by coupling the transport of bicarbona

83 eatment did not exert any negative effect on exocrine pancreas, by inducing either pancreatic inflamm

84 The exocrine pancreas can give rise to endocrine insulin-pro

85 The exocrine pancreas can undergo acinar-to-ductal metaplasi

86 Expression of the homeobox gene Prox1 in the exocrine pancreas changes throughout development in mice

87 To better understand how the exocrine pancreas changes with age, obesity, and diabete

88 The exocrine pancreas, consisting of ducts and acini, is the

89 The majority of the exocrine pancreas consists of the secretory acinar cells

90 t1 has a dual role in the development of the exocrine pancreas: controlling cell proliferation and pr

91 and that maintained ductal fluid flow in the exocrine pancreas could delay the onset of CFRD.

92 Thus, Reg-II is a likely mouse exocrine pancreas cytoprotective candidate protein whose

93 During metamorphic climax when the exocrine pancreas dedifferentiates to progenitor cells,

94 the hypothesis that insulin signaling to the exocrine pancreas determines pancreas volume in multiple

95 Ptf1a is a gene required for exocrine pancreas development and is first expressed as

96 Here, we characterize zebrafish exocrine pancreas development in wild type and mutant la

97 Previous studies have shown that exocrine pancreas development may be modeled in zebrafis

98 hat the inhibition of DHPS impairs zebrafish exocrine pancreas development; however, the link between

99 were required for pancreatic viability; the exocrine pancreas died in mice that were depleted of DCs

100 netic factors likely influence the extent of exocrine pancreas disease in CF ferrets and have implica

101 Interestingly, prior to major exocrine pancreas disease, CF kits demonstrated signific

102 Although CF kits are born with only mild exocrine pancreas disease, progressive exocrine and endo

103 the needed capacity for organ recovery from exocrine pancreas disease.

104 Although both endocrine and the exocrine pancreas display a significant capacity for tis

105 raumatic brain injury or cardiac arrest; and exocrine pancreas DNA was identified in patients with pa

106 Bmi1 expression was up-regulated in the exocrine pancreas during regeneration after cerulein-ind

107 chanistically, we found that the regenerated exocrine pancreas elevated interleukin-6 (IL-6) in PMSC

108 The exocrine pancreas exhibits a reduction in the synthesis

109 comparatively little is known about how the exocrine pancreas forms.

110 itis is caused by inflammatory injury to the exocrine pancreas, from which both humans and animal mod

111 eatorrhea was induced by embolization of the exocrine pancreas gland and pancreatic duct ligation in

112 pletion or inhibition of 12-LOX impairs both exocrine pancreas growth and unexpectedly, the generatio

113 dence of cellular heterogeneity in the human exocrine pancreas has not been yet established because o

114 Tumors of the exocrine pancreas have a poor prognosis.

115 To date, the endocrine and exocrine pancreas have been studied separately by differ

116 The endocrine and exocrine pancreas have been studied separately by endocr

117 ntial role of the M6P pathway in maintaining exocrine pancreas homeostasis and function, and implicat

118 e direct evidence that Men1 is essential for exocrine pancreas homeostasis in response to inflammatio

119 CACs are a functional component of the exocrine pancreas; however, our fate-mapping results ind

120 hylome (using MethylationEPIC arrays) of the exocrine pancreas in 141 donors, assessing the impact of

121 nesis and cytodifferentiation of the gut and exocrine pancreas in a primordial state.

122 sease, T cells infiltrate the islets and the exocrine pancreas in high numbers.

123 ated the role of Prox1 in development of the exocrine pancreas in mice.

124 on and display enhanced UPR signaling in the exocrine pancreas in response to physiological and pharm

125 sizes an underappreciated involvement of the exocrine pancreas in the natural course of type 1 diabet

126 These findings support a role for the exocrine pancreas in the pathogenesis of T1D and highlig

127 ment and underscore a potential role for the exocrine pancreas in the pathogenesis of type 1 diabetes

128 ease in the VMAT2-positive fiber area in the exocrine pancreas in these early diabetic BB rats.

129 increased density of leukocytes) within the exocrine pancreas in this disease, but the mechanisms un

130 cer (11)C-hydroxytryptophan in endocrine and exocrine pancreas in vitro and in vivo.

131 of a differentiated acinar phenotype in the exocrine pancreas in vivo.

132 in cey mutants, including HSPCs, the retina, exocrine pancreas, intestine, and jaw cartilage.

133 fore promote a transdifferentiation of adult exocrine pancreas into hepatocyte-like cells, and chroni

134 ing knowledge about normal physiology of the exocrine pancreas is essential for investigations into t

135 The pancreatic anlage that gives rise to the exocrine pancreas is located in the ventral gut endoderm

136 t collateral damage from inflammation in the exocrine pancreas is not a likely cause of DM in these d

137 Growth of exocrine pancreas is regulated by gastrointestinal hormo

138 The exocrine pancreas is regulated by various hormonal facto

139 The exocrine pancreas is the main source of digestive enzyme

140 In contrast, exocrine pancreas K8 and K18 are dispensable and are co-

141 They are deeply embedded in the exocrine pancreas, limiting their accessibility for func

142 r tissues, including the heart, vasculature, exocrine pancreas, liver, and central nervous system.

143 The exocrine pancreas, liver, and submandibular glands of th

144 gene, the secretion of human insulin by the exocrine pancreas normalized elevated blood glucose leve

145 ctional blood flow between the endocrine and exocrine pancreas, not necessarily a unidirectional bloo

146 the elastase promoter not only protects the exocrine pancreas of a transgenic tadpole from TH-induce

147 The exocrine pancreas of adult mice can be remodeled by re-e

148 y, we report that CD8 T cells infiltrate the exocrine pancreas of diabetic subjects in high numbers a

149 copy and immunohistochemical analysis in the exocrine pancreas of multiorgan donors with T1D (both at

150 the effects of exenatide (EXE) treatment on exocrine pancreas of nonhuman primates.

151 doublet beta cells scattered throughout the exocrine pancreas of the transgenic mice.

152 the effects of constitutive ER stress in the exocrine pancreas of these mice.

153 Exocrine pancreases of transgenic tadpoles expressing a

154 n of the probe, with virtually no binding to exocrine pancreas or stromal tissues.

155 The exocrine pancreas plays an important role in endogenous

156 Cells of the exocrine pancreas produce digestive enzymes potentially

157 adverse actions of sitagliptin treatment on exocrine pancreas raise concerns that require further ev

158 P) is a painful inflammatory disorder of the exocrine pancreas, ranking as the most common gastrointe

159 After metamorphosis is complete the exocrine pancreas redifferentiates in the growing frog f

160 s study reveals a previously unknown role of exocrine pancreas regeneration in safeguarding beta cell

161 bryos display accelerated differentiation of exocrine pancreas relative to wild-type clutchmate contr

162 At metamorphosis the Xenopus laevis tadpole exocrine pancreas remodels in two stages.

163 issue was highly selective in the epidermis, exocrine pancreas, renal glomeruli, the red pulp of the

164 This reduces enzyme production by the exocrine pancreas, resulting in digestive insufficiencie

165 The action of several exocrine pancreas secretagogues depends on the second me

166 The exocrine pancreas secretes fluid and digestive enzymes i

167 The liver and exocrine pancreas share a common structure, with functio

168 lete neoplastic transformation of the entire exocrine pancreas shortly after birth.

169 ounts and chemotaxis as well as a diminished exocrine pancreas size in a SRP54-knockdown zebrafish mo

170 Most importantly, the increase in exocrine pancreas size, protein/DNA content, and acinar

171 on factor 1-L complex (PTF1-L) in regulating exocrine pancreas-specific gene expression.

172 Exocrine pancreas-specific overexpression of CN inhibito

173 Thus, LRH-1 is a key regulator of the exocrine pancreas-specific transcriptional network requi

174 rly to the main islet, as well as defects in exocrine pancreas specification and differentiation.

175 s), the membrane-bound secretory vesicles in exocrine pancreas, swell in response to GTP mediated by

176 tudies also reveal the spare capacity of the exocrine pancreas that allows normal growth and developm

177 ctrum of fibro-inflammatory disorders of the exocrine pancreas that includes calcifying, obstructive,

178 ype 1 diabetes includes abnormalities in the exocrine pancreas that may induce endocrine cellular str

179 on and pancreatitis, and inflammation of the exocrine pancreas that promotes development of pancreati

180 ancreatitis is a debilitating disease of the exocrine pancreas that, under chronic conditions, is a m

181 In the exocrine pancreas, the spatiotemporal properties of Ca(2

182 IL-1betaAb treatment also protected the exocrine pancreas; the number of infiltrating macrophage

183 In the exocrine pancreas, these peptides not only regulate norm

184 n order to reveal a possible requirement for exocrine pancreas tissue in endocrine development and/or

185 Endocrine and exocrine pancreas tissues are both derived from the post

186 om 150 nm in diameter in acinar cells of the exocrine pancreas to 12 nm in neurons.

187 not suffer from DM links the disease in the exocrine pancreas to a pathological process in the endoc

188 (TH) induces dedifferentiation of the entire exocrine pancreas to a progenitor state.

189 Instead, we found the exocrine pancreas to be the major site of AFGP synthesis

190 that actin-coated secretory vesicles of the exocrine pancreas travel this distance over bundles of s

191 Thus, the exocrine pancreas undergoes distinct changes as individu

192 , the predominant cellular alteration in the exocrine pancreas was acinar metaplasia in which individ

193 istorically, diabetes due to diseases of the exocrine pancreas was described as pancreatogenic or pan

194 ue-regulated phosphorylation of hsp27 in rat exocrine pancreas was investigated both in vivo and in i

195 cute inflammatory phase, the recovery of the exocrine pancreas was massively impaired in Postn-defici

196 of Bmi1(-/-) mice were hypoplastic, and the exocrine pancreas was replaced with ductal metaplasia th

197 To address this issue in the exocrine pancreas we analyzed the Bmi1-labeled cell line

198 s with newly diagnosed adenocarcinoma of the exocrine pancreas were compared with 388 general populat

199 rs]) with unresectable adenocarcinoma of the exocrine pancreas were treated, 106 with neutron irradia

200 em cells (PMSCs) are capable of regenerating exocrine pancreas when implanted into the kidney capsule

201 atin overexpression has minor effects on the exocrine pancreas whereas significant keratin overexpres

202 activity and duct cells within the liver and exocrine pancreas, whereas hepatocyte and acinar pancrea

203 G alpha and G beta gamma subunits in the rat exocrine pancreas which is highly specialized for protei

204 Progression of diseases of the exocrine pancreas, which include pancreatitis and cancer

205 were continuously integrated to those in the exocrine pancreas, which made the islet circulation rath

206 of dilute acetic acid solution, ablated the exocrine pancreas while preserving the endocrine pancrea

207 MPCs give rise to the endocrine and exocrine pancreas, while Ngn3(+) EPs specify pancreatic

208 lation of differentiated acinar cells in the exocrine pancreas whose derivatives are still present, a

209 is, but also inflammatory destruction of the exocrine pancreas with diffusely up-regulated expression

210 nregenerative, near-complete ablation of the exocrine pancreas, with complete preservation of the isl

211 atic capillaries were regularly found in the exocrine pancreas, with small lymphatic vessels located